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Papers - Suzuki, Sayo

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Design, synthesis, and monoamine oxidase inhibitory activity of (+)-cinchonaminone and its simplified derivatives.

Sato Yuta, Oyobe Naoko, OGAWA Takao, Suzuki Sayo, Aoyama Hiroshi, Nakamura Tomonori, Fujioka Hiromichi, Shuto Satoshi and Arisawa Mitsuhiro.

ACS Medicinal Chemistry Letters 12 ( 9 ) 1464 - 1469 2021.08

Research paper (scientific journal), Joint Work, Accepted, ISSN 1948-5875

The absolute structure of an indole alkaloid (+)-cinchonaminone by total synthesis of both (+)-cinchonaminone and its enantiomer was determined. The main focus of the study was the enantioselective synthesis of both enantiomers of a chiral cis-3,4-disubstituted piperidine. We also evaluated monoamine oxidase (MAO) inhibitory activities of these enantiomers. Furthermore, its structurally simplified derivatives were synthesized that did not have any chiral center. Two of these derivatives showed stronger MAO inhibitory activities than that of (+)-cinchonaminone.

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Drug repositioning of antipsychotic drugs for cisplatin-induced pica behavior in mice.

Sekiguchi Mayu, Sagano Nanami, Kawzoe Hitoshi, Hiraga Yui, Jibiki Aya, Yokoyama Y,uta Suzuki Sayo, Nakamura Tomonori.

Pharmazie 76 ( 10 ) 484 - 487 2021.07

Research paper (scientific journal), Joint Work, Accepted, ISSN 00317144

We aimed to clarify whether various antipsychotics ameliorate cisplatin-induced pica behavior in mice using a drug repositioning approach. Mice were administered cisplatin (12.5 mg/kg, i.p.) with or without olanzapine (1 mg/kg, i.p.), asenapine (4 mg/kg, i.p.), mirtazapine (5 mg/kg, i.p.) or standard three-drug antiemetics (granisetron [0.5 mg/kg, i.p.], fosaprepitant [25 mg/kg, i.p.], and dexamethasone [3 mg/kg, i.p.]). Kaolin, food, and water intake, and spontaneous motor activity on the day before and seven consecutive days after the cisplatin administration were measured using a telemetry system. At the primary endpoint, kaolin intake was significantly higher at day three in the cisplatin group than in the pre-treatment and saline groups (p < 0.05). Additionally, kaolin intake was not significantly higher in cisplatin with olanzapine, asenapine, and mirtazapine groups for seven days than in the pre-treatment group. At the secondary endpoint, cisplatin decreased the food and water intake, and spontaneous motor activity in a time-dependent manner. Three antipsychotics failed to improve the cisplatin-induced decrease in food and water intake, and spontaneous motor activity. The findings suggest that prophylactic administration of antipsychotics besides olanzapine may improve cisplatin-induced nausea and vomiting in a delayed phase and de-escalate standard 3-drug antiemetics.

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Evaluation of long-term storage stability of antimicrobial agents, antiviral agents, and sodium chloride eye drops prepared in the hospital.

Takeda Mami, Yokoyama Yuta, Watanabe Takeaki, Hiraga Yui, Jibiki Aya, Kawazoe Hitoshi, Suzuki Sayo, Kadota Keiko, Nakamura Tomonori

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) (Japanese Society of Pharmaceutical Health Care and Sciences) 47 ( 6 ) 316 - 325 2021.06

Research paper (scientific journal), Joint Work, Accepted, ISSN 1346-342X

It is necessary to determine the expiration date and storage methods for in-hospital preparations. However, data on the physical properties and stability of in-hospital preparations for eye drops, especially in long-term storage, are limited. Therefore, the stability of in-hospital preparations for eye drops, 0.5％ vancomycin (VCM), 0.25％ DENOSINE® (GCV), 0.1％ Funguard® (MCFG), 1％ VFEND® (VRCZ), and 5％ sodium chloride (NaCl), were evaluated for long-term storage.All eye drops were stored for 12 weeks under the following conditions: cool (4℃)/darkness, room temperature(approximately 23℃)/darkness, room temperature (approximately 24℃)/scattered light (approximately 1,500 lx), or high temperature (37℃)/darkness. The concentration of eye drops over time was measured by high-performance liquid chromatography and automated clinical chemistry analyzer, and pH, appearance, and sterility were evaluated.As a result, 0.5％ VCM eye drops can be stored for 3 weeks at room temperature when placed in a light-shielding bag or for 12 weeks at 4℃. The 0.25％ GCV, 1％ VRCZ, and 5％ NaCl eye drops can be stored for 12 weeks at 4 - 37℃. The 0.1％ MCFG eye drops can be stored for 6 weeks at 37℃, or for 12 weeks at room temperature or 4℃.The stability of in-hospital preparations for eye drops during long-term storage under varying conditions was demonstrated. Therefore, the use of in-hospital preparations for eye drops is considered to be safer and more effective.

The Effect of Minimum Medical Conditions and Community Pharmacy Practice on Outcome in Hospital Pharmaceutical Practice.

清宮啓介, 津田壮一郎, 池淵由香, 鈴木小夜, 地引綾, 岩田紘樹, 横山雄太, 河添仁, 小林典子, 藤本和子, 山浦克典, 中村智徳, 村松博, 青森達, 望月眞弓

医療薬学 46 ( 12 ) 715 - 721 2020.12

Research paper (scientific journal), Joint Work, Accepted

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Pharmacy students’ self-efficacy for pharmaceutical expertise affects successful experiences as enactive attainments in pharmacy practice experience in Japan.

Fumihiro Kikuyama, Sayo Suzuki*, Aya Jibiki, Yuta Yokoyama. Hitoshi Kawazoe, Tomonori Nakamura.

YAKUGAKU ZASSHI (The Pharmaceutical Society of Japan) 140 ( 6 ) 799 - 808 2020.06

Research paper (scientific journal), Joint Work, Corresponding author, Accepted, ISSN 00316903

Pharmacy practice experience (PPE) is essential in the six-year course of pharmaceutical education in Japan. We previously found that PPE reinforced students' self-efficacy for curriculums (SECs), leading robust acquisition and reconstruction of pharmaceutical expertise. In this study, we aimed to clarify whether students' SECs affect successful experiences as enactive attainments in PPE. We distributed survey questionnaires to the fifth-year students in Keio University in 2016-2017 before and after PPE. The students made a self-assessment of their psychological state "expect to do well" on a seven-point Likert scale for each curriculum (C1 to C18), and their successful experiences were also collected from free description type questionnaire. We could follow up 139 students. The SEC scores increased from pre-PPE to post I (p<0.001) and II terms (p<0.01). The increase in SEC scores during PPE was associated with the rate of students' successful experiences in the first-term PPE (p=0.04). The path analysis revealed the following as significant predictive factors of SECs for successful experiences: basic sciences (C1, C2, C3, C4, C5, and C6) with stand-ardizing coefficient 0.35, health and environmental sciences (C11 and C12) with 0.39, and pharmaceutical sciences (C7, C8, C9, C10, C13, and C14) with −0.51. Students in the first-term PPE tended to experience successful performance in medical professions by using their pharmaceutical expertise that they had learned. In this study, for the first time, we demonstrated that Japanese students' SECs for pharmaceutical expertise affected successful experiences, leading better outcomes of PPE.

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デキサメタゾン配合後における先発及び後発品のゲムシタビン注射剤の製剤学的安定性の評価

吉浦誠海, 河添仁, 鈴木小夜, 横山雄太, 地引綾, 中村智徳

日本臨床腫瘍薬学会雑誌 ((一社)日本臨床腫瘍薬学会) 14 1 - 7 2020.04

Research paper (scientific journal), Joint Work, Accepted

ゲムシタビン誘発性血管痛は末梢静脈投与で生じ、臨床上未解決のままとなっている。エピルビシンとオキサリプラチンにおける先行研究によれば、抗炎症作用とpH調整目的にデキサメタゾンがオプションとなる。本研究の目的は、先発及び後発品のゲムシタビンとデキサメタゾン配合の製剤学的安定性を調査することであった。我々はデキサメタゾン配合後の凍結乾燥製剤及び液体製剤のゲムシタビン先発及び後発品11品目の濃度、pH及び外観変化を生理食塩液及び5%ブドウ糖液希釈において24時間後まで評価した。濃度とpHはそれぞれ高速液体クロマトグラフィーとpHメータで測定した。配合液の濃度及びpHは生理食塩液及び5%ブドウ糖液希釈において24時間後まで変化しなかった。ゲムシタビンの液体製剤のpHは凍結乾燥製剤と比較して、生理食塩液及び5%ブドウ糖液希釈においてわずかに低かった。さらに、生理食塩液及び5%ブドウ糖液希釈において外観変化はなかった。これらの結果は、すべての先発及び後発品のゲムシタビンの製剤学的安定性はデキサメタゾン配合によって影響を受けなかった。本研究は、実臨床においてゲムシタビン誘発性血管痛の可能性を減らすために、先発及び後発品のゲムシタビンはデキサメタゾンと配合投与できることを示唆する。(著者抄録)

Educational Effect of Practical Training on Students' Robust Acquisition and Reconstruction of Expertise on Pharmaceutical Sciences They Had Learned before Practical Training

Kikuyama Fumihiro, Suzuki Sayo, Nakamura Tomonori

YAKUGAKU ZASSHI (The Pharmaceutical Society of Japan) 139 ( 9 ) 1201 - 1209 2019.09

Research paper (scientific journal), Joint Work, Corresponding author, Accepted, ISSN 0031-6903

Long-term practical training in the 6-year course of pharmaceutical education is a program for students after acquiring basic knowledge on pharmaceutical sciences and preclinical training. However, it remains unproved whether practical training affects students' robust acquisition and reconstruction of pharmaceutical expertise which they had learned before starting practical training. To address this issue, we administered survey questionnaires to 5th-year students (n=149) of Keio University in 2016 both before and after practical training. From the viewpoint of self-efficacy, psychological approach was applied to evaluate respondents' psychological state "to do well" on a 7-point Likert scale (1=disagree, 4=neither, 7=agree) for specific subjects C1-C18 (18 core units of pharmaceutical expertise in the current Model Core Curriculum for Pharmaceutical Education), mainly including basic pharmaceutical sciences, public health, clinical pharmacology and pharmacotherapy. C1-C18 total score values, which reflect the strength of certainty to acquire expertise, were significantly higher after the first term of practical training compared to before training, regardless of the pharmacy and the hospital (p<0.001), but not after the second term. Specific factors associated with increased score values for "to do well" were not extracted from other questionnaire answers concerning students' mentors or their self-learning during practical training. These results demonstrated that practical training at least partly reinforced students' feeling of "to do well", contributing to their robust acquisition and reconstruction of pharmaceutical expertise. Giving students recognition individually of their learning process themselves encourages more effective practical training toward their development of resources as a pharmacist.

The Newly Introduced Rubric-based Assessment of Students' Performance during Practical Training:: Measuring Outcome and Suggestions for Improvement Based on Students' Perspective

Suzuki Sayo, Kawazoe Hitoshi, Jibiki Aya, Yokoyama Yuta, Nakamura Tomonori

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) (Japanese Society of Pharmaceutical Health Care and Sciences) 45 ( 4 ) 228 - 239 2019.04

Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted, ISSN 1346-342X

To prepare for a new practical training scheme starting in 2019 based on a revised-model core curriculum for pharmaceutical education that incorporates outcome-based education, rubric-based assessment of student performance was implemented in practical training between May and July of 2018. The goals were to evaluate the rubric-based assessment to identify ways to improve it for appraising pharmaceutical students. All fifth-year students of the Keio University Faculty of Pharmacy in 2018 (n = 160) self-assessed their performance during practical training using evaluation sheets in a rubric form comprising three general instructional objectives with 10 task descriptions developed by the Japanese Pharmaceutical Association or Japanese Society of Hospital Pharmacists. Compared to the commencement of the training, the median evaluations in all tasks significantly increased at the completion of the practical training in the community pharmacy and the hospital settings. Survey questionnaires were administered to the students after the practical training. Customer satisfaction analysis identified two main areas for improvement of the rubric-based assessment for student growth: (1) students' lack of understanding of the rubric-based assessment in hospitals and (2) mentors' lack of understanding of it in both settings. The results suggest that rubric-based assessment is a feasible method for assessing pharmaceutical student performance during practical training. Additionally, the Faculty of Pharmacy should provide and disseminate information to students and mentors about rubric-based assessment and support mentors' efforts for student progress during practical training.

Renal dysfunction and anemia associated with long-term imatinib treatment in patients with chronic myelogenous leukemia.

Masatoshi Sakurai, Daiki Karigane, Hidenori Kasahara, Eri Matsuki, Risa Hashida, Yusuke Yamane, Ryohei Abe, Yuya Koda, Takaaki Toyama, Taku Kikuchi, Jun Kato, Takayuki Shimizu, Yuta Yokoyama,Suzuki Sayo, Tomonori Nakamura, Shinichiro Okamoto, and Takehiko Mori.

Int J Hematol. 109 ( 3 ) 292 - 298 2019.01

Research paper (scientific journal), Joint Work, Accepted, ISSN 09255710

© 2019, Japanese Society of Hematology. Knowledge of the toxicity profile of long-term treatment with imatinib is limited. In the present study, we sought to evaluate renal function and hemoglobin levels during long-term imatinib treatment. Eighty-two patients with chronic myelogenous leukemia in chronic phase who had been on imatinib for over 5 years were retrospectively analyzed. The mean estimated glomerular filtration rate (eGFR) was significantly decreased over 5 years (77 ± 17 to 62 ± 14 ml/min/1.73m², P < 0.001). Higher age and lower eGFR value at initiation of imatinib were significantly associated with development of renal dysfunction by multivariate analyses. Mean hemoglobin levels also significantly decreased over the 5-year period (12.9 ± 1.7 to 12.4 ± 1.3 g/dl, P < 0.01). The rate of decrease in eGFR correlated significantly with hemoglobin levels (correlation coefficient = − 0.249, P < 0.05). Serum erythropoietin (EPO) levels did not increase in 16 patients with both renal dysfunction and anemia (median, 31.9 mIU/ml). In patients who participated in a clinical trial of imatinib discontinuation, mean eGFR (50.0 ± 6.5 to 56.0 ± 10.2 ml/min/1.73m², P < 0.05) and hemoglobin levels (12.0 ± 1.7 to 14.0 ± 1.6 g/dl, P < 0.01) improved significantly at 1 year after discontinuation. These findings suggest that long-term imatinib results in a partially reversible continuous decline in renal function and decreased hemoglobin levels.

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Macrophage-selective inhibitory effect of Kikyo-to, a Japanese traditional kampo medicine, on the viability of mouse macrophage RAW264.7 cells.

Seki Kengo, Suzuki Sayo, Mori Takehiko, Nakamura Tomonori

Proceedings for Annual Meeting of The Japanese Pharmacological Society (Japanese Pharmacological Society) 92 ( 0 ) 3 - O-13 2019

Research paper (other academic), Joint Work, Corresponding author, Accepted

Kikyo-to is a kampo medicine which is composed of Platycodi Radix (PR) and Glycyrrhizae Radix (GR), and used for Pharyngitis. As previous research in our laboratory has found the possibility that kikyo-to could influence cell viability of RAW264.7, we examined the effect of kikyo-to in detail. Decoction of both crude PR and GR, that is kikyo-to (K-D), or each crude herbal medicine, or aqueous solution of extract granule preparation of kikyo-to (K-G) were exposed to RAW264.7 mouse macrophage-derived cells, CACO-2 human colorectal cancer cells and K562 human blood cancer cells. Viability of these cells were evaluated after exposure of various dilution of these preparations.K-D decreased cell viability of RAW264.7 in a time and concentration-dependent manner and K-G also decreased cell viability of RAW264.7 in a concentration-dependent manner. In contrast, the viability of other cells did not change significantly. Decoction of GR alone decreased cell viability of RAW264.7, suggesting that components of GR may contribute to decrease in cell viability of RAW264.7, selectively. To confirm this hypothesis, further studies, functional analysis and clinical validations are needed.

Assessing pharmaceutical students' performance in practical training in a hospital:—Developing rubrics of the Keio University version and preliminary validation

Suzuki Sayo, Nakamura Tomonori

Japanese Journal of Pharmaceutical Education (Japan Society for Pharmaceutical Education) 2 ( 0 ) n/a 2018.08

Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted, ISSN 2432-4124

Since 2015, in Keio University, we have developed a set of holistic rubrics for assessing students' performance in practical training in their fifth year. We have administered it on a series of trials in Keio University Hospital in 2016 and 2017 to prepare for the practical training in 2019, which is based on a "revised model core curriculum for pharmaceutical education" incorporating out-come based education. The first and second trials in 2016 identified some problems. The mentors felt burdened, and the rubrics did not work well because the descriptions of performance at each achievement level were unclear. To address these issues, first, we revised the rubrics and added examples to help mentors with the assessment. Second, the assessment frequency was decreased. Furthermore, we also organized faculty-led orientation sessions on using the rubrics not only for mentors but for all pharmacists in the facility. These efforts have resulted in the effective use of the rubrics in the subsequent 2017 trial, thus reducing the mentors' burden of using the rubrics. This is not so different from using the rating scale of Specific Behavioral Objectives (SBOs). Furthermore, to mentors, the rubrics seemed to be more proper and objective for assessing students' performance than the SBOs' rating scale.Based on these results, it is feasible to use rubrics for assessing pharmaceutical students' performance in practical training. However, effective efforts, as follows, are needed: (a) making rubrics clearer and more user-friendly, (b) familiarizing the rubrics, and (c) building unity of purpose among relevant staff.

Population pharmacokinetics of intravenous busulfan in Japanese pediatric patients with primary immunodeficiency.

Yasuyoshi Ishiwata, Masashi Nagata, Kohta Tsuge, Hiromitsu Takahashi, Sayo Suzuki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Tomohiro Morio, Masato Yasuhara

J Clin Pharmacol 58 ( 3 ) 327 - 331 2018.02

Research paper (scientific journal), Joint Work, Accepted

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Development of a new scholastic program for medication counseling practice in preclinical training, constructed for junior students by senior students based on their experiences of on-site practice.

Suzuki Sayo

YAKUGAKU ZASSHI (日本薬学会) 137 ( 11 ) 1391 - 1408 2017.11

Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted, ISSN 00316903

© 2017 The Pharmaceutical Society of Japan. Long-term practical on-site training, based on the Model Core Curriculum for Pharmaceutical Education, is a core program of the 6-year course of pharmaceutical education, introduced in Japan in 2010. In particular, medication counseling in practical training in 5th-year provides valuable opportunities for communication with real patients rather than simulated patients (SPs). However, it can also cause anxiety in 4th-year students before practical training. To address such concerns, upperclassmen (5th-and 6th-year students), who have already completed practical training, constructed and conducted a new educational program for medication counseling practice in preclinical training based on their experiences. They also developed case scenarios and played the role of patients themselves to create more realistic clinical settings. Advice from professional SPs was also provided. The 5-step program is composed of 1st counseling, 1st small group discussion (SGD) for improving counseling, 2nd revised counseling based on the 1st SGD, 2nd SGD, and development of a counseling plan and presentation. Educational effects of the program were evaluated by questionnaire survey after preclinical training in 4th-year students and after their practical training in 5th-year students. This new program, the Advanced Medication Counseling Practice, was found to be useful to reduce anxiety about communication with patients among 4th-year students (about 90%). Even after their practical training in 5th-year, they still appreciated usefulness of this program (about 80%). This program is still valued 4 years after its development. We developed the Advanced Medication Counseling Practice in preclinical training for junior students by senior students.

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電子味覚システムとヒト官能試験によるクリンダマイシンの苦味抑制飲食物の探索．

Suzuki Sayo

医療薬学 (日本医療薬学会) 43 ( 9 ) 492 - 501 2017.09

Research paper (scientific journal), Joint Work, Corresponding author, Accepted

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The problems and improvement plans for student’s satisfaction of OTC drugs practices in pre-clinical training and clinical practice in community pharmacy

Suzuki Sayo

薬学教育 (日本薬学教育学会) 1 1 - 8 2017.08

Research paper (scientific journal), Joint Work, Accepted, ISSN 2432-4124

薬局実務実習を終えた薬学部5年生151人と、実務実習を受け入れた延べ125薬局を対象とした。OTC薬の実習内容は、「販売」44名、「RP+見学」39名、「見学のみ」26名、「RPのみ」28名、「いずれも実施せず」13名、無回答1名であった。OTC薬実習に対して「興味」、「十分」、「満足度」を問う質問に対して「そう思う」と回答した学生は、それぞれ110名、54名、69名であった。OTC薬の種類に関する知識の必要性を感じた学生は131名、OTC薬の成分や薬理作用に関する知識の必要性を感じた学生は126名、疾患や病態の知識の必要性を感じた学生は137名であった。OTC薬実習の総合満足度を改善する因子の探索をCS分析で行い、改善度が高かった順に「学生による実際の販売(相談販売)」、「薬剤師がOTC薬を販売しているところの見学」、「OTC薬選択となる疾患や症状の基準」「学生による実際の販売(指名販売)」であった。8割以上の薬局薬剤師はOTC薬実習に関するSBOsを達成することに困難を感じていた。指導薬剤師は学生のコミュニケーションスキルの不足を感じていた。

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Suppression of antibody to infliximab by azathioprine in a patient with rheumatoid arthritis.

Aomori Tohru, Tsuchiya Ayumi, Suzuki Sayo, Jibiki Aya, Otsuka Naoko, Ishioka Eriko, Kaneko Yuko, Takeuchi Tsutomu, Nakamura Tomonori.

Die Pharmazie 72 ( 2 ) 95 - 97 2017.02

Research paper (scientific journal), Joint Work, Accepted, ISSN 00317144

© 2017, Govi-Verlag Pharmazeutischer Verlag GmbH. All rights reserved. In rheumatoid arthritis (RA) treatment, the concomitant use of methotrexate has been shown to reduce the incidence of antibodies to infliximab (ATI), on the other hand, it is unclear whether azathioprine can reduce ATI production. We enrolled a total of 10 Japanese adult patients with RA who were treated with infliximab concomitantly with methotrexate or azathioprine. Serum concentrations of infliximab and ATI of these patients were measured. The mean serum infliximab concentrations was 1.6±1.3 μg/ml in patients with methotrexate and 1.0±0.5 μg/ml in patients with azathioprine. Serum ATI concentrations were below the limit of quantitation in 4 of 5 patients in each group. The results from the present study suggest that azathioprine suppresses ATI production.

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Effect of genetic polymorphisms of azathioprine-metabolizing enzymes on response to rheumatoid arthritis treatment.

Ayumi Tsuchiya, Tohru Aomori, Mami Sakamoto, Arisa Takeuchi, Suzuki Sayo, Aya Jibiki, Naoko Otsuka, Eriko Ishioka, Yuko Kaneko, Tsutomu Takeuchi, Tomonori Nakamura.

Die Pharmazie 72 ( 1 ) 22 - 28 2017.01

Research paper (scientific journal), Joint Work, Accepted, ISSN 00317144

© 2017, Govi-Verlag Pharmazeutischer Verlag GmbH. All rights reserved. Azathioprine (AZA) is increasingly being prescribed to rheumatoid arthritis (RA) patients. Following oral administration, AZA is converted into its active form. Inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE) patients with low thiopurine (S)-methyltransferase (TPMT) activity tend to respond well to AZA therapy. In a previous study of Japanese SLE patients under low-dose AZA therapy, the group with the 94C>A mutation in inosine triphosphatase (ITPA) showed greater improvement in their disease activity index. However, it is not yet clear how genotypes relate to responsiveness to RA treatment. The genotypes ITPA 94C>A, TPMT∗3C, NUDT15 595C>T, GST-M1, GST-T1 and MRP4/ABCC4 2269G>A of Japanese patients with RA were determined. The relationship between these genotypes and response to AZA therapy was evaluated using the Disease Activity Score 28 (DAS28) and various medical data. Of the 22 patients 15 had the ITPA 94C/C genotype, 7 had the ITPA 94C/A genotype, none had the TPMT∗3C mutation, 4 had the NUDT15 595C>T mutation, 8 had the GST-M1 and T1 null genotypes and 9 had the MRP4/ABCC4 2269G>A mutation. Changes in DAS28 at 6 months after baseline were similar in both ITPA genotype groups. However, the maintenance dose of AZA was significantly lower in the C/A group than in the C/C group (0.85±0.30 mg/kg/day vs. 1.2±0.46 mg/kg/day, respectively; p = 0.043). The ITPA 94C/A group showed the same response to RA treatment as the C/C group, but at a lower dose. This demonstrates that RA patients with the ITPA 94C>A mutation are more responsive to AZA.

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Meta-analytic population pharmacokinetic analysis to evaluate the effect of renal dysfunction on imatinib clearance in Japanese subjects.

Suzuki S, Hattori Y, Takagi A, Aomori T, Kasai H, Nakamura T.

Proc Annu Meet IATDMCT 2017

Research paper (international conference proceedings), Joint Work, Lead author, Corresponding author, Accepted

Forced expression of S100A10 reduces sensitivity to oxaliplatin in colorectal cancer cells.

Suzuki S, Tanigawara Y*.

Proteome Science (BioMed Central) 12 ( 1 ) 26 2014.05

Research paper (scientific journal), Joint Work, Lead author, Accepted

Background: Individual responses to oxaliplatin (L-OHP)-based chemotherapy remain unpredictable. Our recent proteomics studies have demonstrated that intracellular protein expression levels of S100A10 are significantly correlated with the sensitivity of colorectal cancer (CRC) cells to L-OHP, but not 5-FU, suggesting that S100A10 is a candidate predictive marker for the response to L-OHP. In this study, we investigated whether S100A10 is involved in L-OHP sensitivity or not.Results: Forced expression of S100A10 in COLO-320 CRC cells significantly increased the 50% inhibitory concentration (IC50) for L-OHP (P = 0.003), but did not change that for 5-FU, indicating that S100A10 is more specific to L-OHP than 5-FU. Silencing of the S100A10 gene showed no apparent effect on sensitivity to L-OHP in HT29 cells. Silencing of the annexin A2 (a binding partner of S100A10) gene alone downregulated both annexin A2 and S100A10 protein levels, with no change in S100A10 gene expression. However, original levels of intact S100A10 protein in CRC cells positively correlated with S100A10 mRNA levels (P = 0.002, R = 0.91).Conclusions: The present results have shown that protein expression of S100A10 was associated with resistance to L-OHP, but not 5-FU, supporting the hypothesis that S100A10 expression may predict L-OHP sensitivity. Thus, our present study provides basic findings to support that S100A10 expression can be used as a predictive marker for tumor sensitivity to L-OHP. © 2014 Suzuki and Tanigawara; licensee BioMed Central Ltd.

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OTC薬実習の問題点とその改善のための提案.

剱田侑希, 門田佳子, 鈴木小夜, 青森達, 小林典子, 高木彰紀, 手塚淑人, 大谷壽一, 中村智徳*.

医療薬学誌 (日本医療薬学会) 40 ( 2 ) 117 - 123 2014.02

Research paper (scientific journal), Joint Work, Accepted

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