Jibiki, Aya

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 医療薬学・社会連携センター　医療薬学部門 ( Shiba-Kyoritsu )

Position

Research Associate/Assistant Professor/Instructor

Career 【 Display / hide 】

  • 2005.04
    -
    2014.07

    University of Tsukuba Hospital, Department of Pharmacy, Chief

  • 2014.08
    -
    Present

    Keio University, Faculty of Pharmacy, Division of Pharmaceutical Care Sciences, Research Associate

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Academic Background 【 Display / hide 】

  • 1999.04
    -
    2003.03

    Meiji Pharmaceutical University, 薬学部

    University, Graduated

  • 2003.04
    -
    2005.03

    Chiba University, 大学院薬学研究院

    Graduate School, Completed, Master's course

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Licenses and Qualifications 【 Display / hide 】

  • Pharmacist license, 2003.06

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Research Areas 【 Display / hide 】

  • Life Science / Clinical pharmacy

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Research Keywords 【 Display / hide 】

  • proper use of steroids, connective tissue disease, menopausal syndrome, osteoporosis, bitter-taste masking of medicine

  • 更年期障害に対する薬物治療

  • Kampo Medicine

  • 膠原病

  • 医薬品の苦味マスキング

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Research Themes 【 Display / hide 】

  • 更年期障害に対する漢方製剤処方実態調査および漢方治療不応例の要因分析, 

    2018.02
    -
    2021.03

    　View Summary

    更年期障害の女性に対する漢方製剤処方実態調査を行うとともに、漢方治療の不応例についてその要因を分析し、更年期障害に対する漢方製剤を中心とした薬物治療の最適化、個別化につなげていく

  • グルココルチコイド（GC）使用膠原病患者におけるGC誘発性糖尿病に対する処方実態調査および治療薬の有用性の検討, 

    2017.12
    -
    2020.03

    　View Summary

    GC製剤を使用している膠原病患者において、糖尿病（GC誘発性糖尿病）の発現状況、GC誘発性糖尿病に対する治療薬の処方実態や臨床検査値等について調査し、各種糖尿病治療薬のGC誘発性糖尿病に対する有用性について検討する。

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Books 【 Display / hide 】

  • こどもと薬のＱ＆Ａ続

    石川洋一　監修　小児薬物療法研究会　編集（編集協力者：地引　綾）, じほう, 2018.09

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Papers 【 Display / hide 】

  • Three Kampo medicines—bofutsushosan, boiogito, and daisaikoto—have different effects on host fat accumulation and the intestinal microbiota in a high-fat-diet–induced mouse model of obesity

    Nakamichi K., Yoshino T., Akiyama M., Jibiki A., Yokoyama Y., Kawazoe H., Suzuki S., Watanabe K., Kim Y.G., Nakamura T.

    Journal of Natural Medicines 79 ( 5 ) 1044 - 1056 2025.09

    ISSN  13403443

    　View Summary

    Inhibiting body fat accumulation is important for the prevention of obesity. In Japan, three Kampo medicines are commonly used to treat obesity: bofutsushosan, boiogito, and daisaikoto. To compare the influences of these Kampo medicines on the intestinal microbiota, it is necessary to conduct a simultaneous investigation using the same mouse model under the same experimental conditions. C57BL/6J mice were divided into five groups: normal chow (NC), high-fat diet (HFD), HFD + 3% bofutsushosan extract (BTS), HFD + 3% boiogito extract (BOT), and HFD + 3% daisaikoto extract (DST). Epididymal white adipose tissue (WAT) weight, mesenteric WAT weight, serum triglyceride levels, and serum total cholesterol levels were measured. Additionally, total bacteria, alpha diversity, beta diversity, and bacterial composition in stool samples were measured. Body weight and epididymal WAT weight gain were significantly inhibited in the BTS-treated group and DST-treated group, but not in the BOT-treated group, compared with the HFD control group. Additionally, serum total cholesterol levels were significantly lower in the DST-treated group than in the HFD group. Specific intestinal bacteria, Clostridium sensu stricto 1, Erysipelatoclostridium, Roseburia, and the Lachnospiraceae NK4A136 group, were significantly changed in the Kampo-treated groups compared with the HFD group, and each of them was correlated with body weight gain, body fat rate, epididymal WAT weight, or mesenteric WAT weight. Our simultaneous investigation of BTS, BOT, and DST under the same conditions clearly demonstrated different changes in the intestinal microbiota and different effects on fat accumulation as well as their association among the three Kampo medicines.

  • Identification of risk factors and development of a predictive model in patients using cefmetazole for international normalized ratio elevation

    Namiki T., Yokoyama Y., Kimura M., Fukuda S., Seyama S., Iketani O., Samura M., Ishikawa H., Jibiki A., Kawazoe H., Ohtani H., Hasegawa N., Matsumoto K., Hashi H., Suzuki S., Nakamura T.

    Plos One 20 ( 7 July )  2025.07

    　View Summary

    Patient risk factors related to coagulopathy and bleeding when using cefmetazole (CMZ) have not yet been identified, and no models exist to predict side effects during CMZ treatment. Moreover, reports that examine which patients should be careful when using CMZ to ensure safety are lacking. Our objective was to understand risk factors for elevated international normalized ratio (INR) in patients using CMZ and to develop a predictive model for INR elevation using a risk score to enable safe administration of CMZ. This multicenter, retrospective, and observational study was conducted in Tokyo Bay Urayasu Ichikawa Medical Center and Keio University Hospital using data from patients being treated with CMZ. Patients were classified into INR-elevated or non-INR-elevated groups. Univariate and multivariate analyses were performed to calculate the adjusted odds ratios (aOR) and 95% confidence intervals (CI). The actual probability of an elevated INR and probability of an elevated INR predicted by the regression β coefficients were calculated and classified into four categories according to the risk score. Binomial logistic regression analysis revealed that liver disorder (aOR, 5.65; 95% CI, 1.69–18.91; risk scores, 2), nutritional risk (aOR, 6.32; 95% CI, 3.14–12.74; risk scores, 2), no-diabetes mellitus (aOR, 4.53; 95% CI, 1.34–15.26; risk scores, 2), and warfarin use (aOR, 98.44; 95% CI, 7.05–1375.50; risk scores, 5) were significantly associated with INR elevation. The predicted incidence probabilities of INR elevation were<5% (low risk), 5–<30% (medium risk), 30–<90% (high risk), and ≥ 90% (very high risk). The model validity showed a good fit (AUC, 0.79; 95% CI, 0.73–0.85, P<0.001). We identified risk factors that contribute to INR elevation and constructed a model to predict INR elevation using the risk score. Using this predictive model enables the appropriate use of CMZ in a safe manner.

  • Efficacy of De-Escalation to Cefmetazole in Patients with Bacteremic Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase-Producing Escherichia coli

    Namiki T., Yokoyama Y., Kimura M., Fukuda S., Seyama S., Iketani O., Uwamino Y., Jibiki A., Kawazoe H., Ohtani H., Hasegawa N., Matsumoto K., Oda R., Hashi H., Suzuki S., Nakamura T.

    Biological and Pharmaceutical Bulletin 48 ( 5 ) 537 - 544 2025.05

    ISSN  09186158

    　View Summary

    This study aimed to clarify the optimal value for the unbound cefmetazole concentration to remain above the minimum inhibitory concentration (MIC) (fT≥MIC) for efficacy of de-escalation to cefmetazole in patients with bacteremic urinary tract infection by extended-spectrum β-lactamase-producing Escherichia coli. This double-center retrospective observational study was conducted at Tokyo Bay Urayasu Ichikawa Medical Center and Keio University Hospital from January 2012 to October 2022. Efficacy was determined via clinical evaluation (mortality rate, recurrence rate, vital changes) and bacteriological evaluation, and the optimal fT≥MIC was calculated via receiver operating characteristic curve analysis. As a result, the number of patients evaluated were 40 (35 and 5 in the treatment success and treatment failure groups, respectively). Univariate analysis showed that fT≥MIC, recurrence rate, and MIC for cefmetazole against bacteria were significantly different for the two groups (p<0.05). Receiver operating characteristic curve analysis showed that the optimal fT≥MIC indicating efficacy was 57% (area under the curve: 0.94, 95% confidence interval: 0.86–1.00, p=0.002). All patients with fT≥MIC ≥ 57% had successful treatment, whereas the frequency of treatment failure was high among those with fT≥MIC <57%. The optimal fT≥MIC for the clinical efficacy of de-escalation to cefmetazole in patients with bacteremic urinary tract infection by extended-spectrum β-lactamase-producing E. coli was fT≥MIC ≥ 57%. This finding would be useful for optimal dosing of cefmetazole.

  • Analysis of the Stability of 0.04% Mitomycin C Ophthalmic Solution under Various Storage Conditions

    Nonomiya Y., Yamaguchi K., Yokoyama Y., Nakajima I., Hara R., Shoji D., Takiguchi T., Takehana K., Jibiki A., Suzuki S., Nakamura T., Tsuji H., Yamaguchi M.

    Keio Journal of Medicine 74 ( 4 ) 214 - 220 2025

    ISSN  00229717

    　View Summary

    A 0.04% mitomycin C (MMC) ophthalmic solution is not commercially available and is prepared in hospitals as required. The physical properties and stability of the MMC ophthalmic solution have not been clarified because of a lack of data. This study aimed to assess the stability of the MMC ophthalmic solution under various storage conditions. The MMC ophthalmic solution was prepared by dissolving 2 mg of MMC in 5 mL of saline solution. Each batch of ophthalmic solution was stored under three conditions [cold/shaded light, room temperature/shaded light, and room temperature/scattered light (approximately 4000 lx)], and MMC concentration was determined using high-performance liquid chromatography on days 0, 1, 3, 5, 7, 14, and 21. The expiry date was calculated based on the results of the degradation analysis. pH measurements and bacterial culture tests were conducted for each storage condition. The MMC concentrations on day 21 under cold/shaded light, room temperature/shaded light, and room temperature/scattered light were 340, 287, and 227 µg/mL, respectively. MMC concentrations decreased over time, and the decrease was highest when the samples were stored at room temperature and exposed to light, and lowest under cold conditions and protected from light. The pH of MMC solutions was 5.8 after preparation, which increased to 6.9 with time under all storage conditions. Culture tests did not detect any bacteria under any storage conditions. The MMC ophthalmic solution was most stable under cold/shaded conditions, and our study clarifies its expiry date for clinical use.

  • Pharmacokinetics/pharmacodynamics analysis and establishment of optimal dosing regimens using unbound cefmetazole concentration for patients infected with Extended-Spectrum β-lactamase producing Enterobacterales (ESBL-E)

    Namiki T., Yokoyama Y., Hashi H., Oda R., Jibiki A., Kawazoe H., Matsumoto K., Suzuki S., Nakamura T.

    Pharmacotherapy (Pharmacotherapy)  44 ( 2 ) 149 - 162 2023.11

    ISSN  02770008

    　View Summary

    Study Objective: Establish methods for measuring cefmetazole (CMZ) concentrations conduct a pharmacokinetic/pharmacodynamic (PK/PD) analysis using unbound CMZ concentrations for extended-spectrum β-lactamase producing enterobacterales (ESBL-E) and investigate optimal dosing regimens for not undergoing hemodialysis (non-HD) and undergoing hemodialysis (HD) patients. Design: Prospective observational study. Patients: Included patients treated with CMZ who provided written informed consent and were admitted to the Tokyo Bay Urayasu Ichikawa Medical Center between August 2021 and July 2022. Measurements: Total and Unbound CMZ concentration was measured by high-performance liquid chromatography (HPLC) with solid-phase extraction and ultrafiltration. Setting: Determining the CMZ dosing regimen involved modified creatinine clearance (CLCR) with measured body weight (BW) using the Cockcroft–Gault equation. For non-HD patients, blood samples were collected during at least three points. For patients undergoing HD, 1 g was administered via intravenous infusion, or rapid intravenous injection after HD, or 30 min before the end of HD. Blood samples were collected before HD (pre-HD), and 1 and 3 h after starting HD and post-HD. All blood samples were collected at steady-state. Patient information was collected from electronic medical records. An unbound PK model was constructed for the non-HD patients. A nomogram was constructed using Monte Carlo simulations with a 90% probability of target attainment at 70% free time above the minimum inhibitory concentration (MIC). For the HD patients, a nomogram was used to determine the optimal dosing regimen for each HD schedule. Main Results: CMZ measurement methods were established. A model analysis of unbound PK in 37 non-HD patients incorporated creatinine clearance (CLCR) using the Cockcroft–Gault equation, albumin (ALB) for clearance and body weight (BW) for the volume of distribution. In Monte Carlo simulations, nomograms corresponding to the MIC (known and unknown) were generated for each covariate. Using the nomogram, non-HD patients with an ESBL-E MIC of 8 mg/L, a BW of 60 kg, an ALB of 25 g/L, and a CLCR of 60 mL/min required administration of 2 g every 6 h (1- and 3-h infusions). Unbound PK model parameters were calculated for 7 HD patients, and the optimal dosing regimens following PK/PD were determined for each HD schedule. In HD patients, the regimen after and during HD was established using a treatment that was effective up to an ESBL-E MIC of 4 mg/L. Conclusions: The nomogram for CMZ regimens established by PK/PD analysis of measured CMZ concentrations enables optimal CMZ dosing for ESBL-E-infected patients.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Evaluation from Preintroduction to Implementation of Pharmacy Practice Experiences Based on the “Model Core Curriculum for Pharmaceutical Education” Incorporating Outcome-Based Education

    Hitoshi Kawazoe, Hiroki Iwata, Haruki Ishikawa, Shingo Kondo, Aya Jibiki, Yuta Yokoyama, Noriko Kobayashi, Sayo Suzuki1, Katsunori Yamaura, Tomonori Nakamura

    Japanese Journal of Pharmaceutical Health Care and Sciences (Japanese Society of Pharmaceutical Health Care and Sciences)  50 ( 9 ) 455 - 464 2024.09

    Joint Work

  • がん薬物治療における職業性暴露対策の新たな動きと未来展望

    Hitoshi Kawazoe, Sayo Suzuki, Yuta Yokoyama, Aya Jibiki, Tomonori Nakamura

    Japanese Journal of Drug Safety 5 ( 2 ) 67 - 76 2019.12

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • Steroids as cancer medication

    Aya Jibiki, Yuta Yokoyama, Hitoshi Kawazoe, Sayo Suzuki, Tomonori Nakamura

    Japanese Journal of Drug Safety 5 ( 1 ) 1 - 13 2019.06

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • Consideration of cancer treatments and clinical trials for special patient populations

    Sayo Suzuki, Jibiki Aya，Yuta Yokoyama, Hitoshi Kawazoe, Tomonori Nakamura

    Japanese Society of Drug Safety (Japanese Society of Drug Safety)  4 ( 2 ) 83 - 97 2018.12

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • Toward routine therapeutic drug monitoring of the epidermal growth factor receptor-the tyrosine kinase inhibitors

    Yuta Yokoyama, Sayo Suzuki, Jibiki Aya，Hitoshi Kawazoe, Tomonori Nakamura

    Japanese Society of Drug Safety (Japanese Society of Drug Safety)  4 ( 1 ) 3 - 13 2018.07

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • 医原性閉経患者における更年期症状の相関解析

    地引　綾, 上瀧智花乃, 横田めぐみ, 堀場裕子, 吉野鉄大, 仁木晃子, 高畑海音子, 椎名美季, 大野あゆみ, 谷本慧子, 弟子丸亮太, 横山雄太, 野々宮悠真, 鈴木小夜, 山上　亘, 中村智徳

    [Domestic presentation]  第40回日本女性医学学会学術集会 (東京) , 

    2025.11
    , 

    Poster presentation, 一般社団法人 日本女性医学学会

  • 実習初期の省察能力に着目した実務実習生のプロフェッショナリズム向上を目指した教育的介入のための新たな示唆

    梅田小梅, 榎本光晴, 小林聡太, 野々宮菜彌, 金沢和幸, 川島沙織, 地引綾, 横山雄太, 野々宮悠真, 津田壮一郎, 大谷壽一, 中村智徳, 鈴木小夜

    [Domestic presentation]  第10回 日本薬学教育学会大会 (東京) , 

    2025.08
    , 

    Poster presentation, 一般社団法人 日本薬学教育学会

  • Research on daily life activities and health behaviors which affect the Self-Rated Health (SRH) of community-dwelling people with lifestyle-related diseases

    濱田 蘭奈、松元 美奈子、地引 綾、横山 雄太、鈴木 小夜、中村 智徳、武林 亨

    [Domestic presentation]  日本薬学会第145年会 (福岡) , 

    2025.03
    , 

    Poster presentation, 一般社団法人 日本薬学会

  • Development of a simultaneous quantification of total and unbound blood concentrations of cephalosporin antibiotics using HPLC for optimal dosing regimen

    Sawano Tanaka, Yuta Yokoyama, Ryusei Hara, Takaya Namiki, Hideki Hashi, Aya Jibiki, Sayo Suzuki, Tomonori Nakamura

    [Domestic presentation]  The 146th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka) , 

    2025.03
    , 

    Poster presentation,  The Pharmaceutical Society of Japan

  • 当院更年期外来における更年期症状の相関解析

    地引　綾1）、森岡由妃1）、横田めぐみ2）、堀場裕子2）3）、吉野鉄大3）、仁木晃子2）、高畑海音子2）、椎名美季4）、大野あゆみ2）、谷本慧子5）、弟子丸亮太4）、横山雄太1）、河添　仁1）、鈴木小夜1）、山上　亘2）、中村智徳

    [Domestic presentation]  第39回日本女性医学学会学術集会 (栃木) , 

    2024.11
    , 

    Oral presentation (general), 一般社団法人 日本女性医学学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 更年期障害患者に対する最適な治療薬選択を目指したエストロゲン受容体遺伝子解析

    2021.04
    -
    2022.03

    慶應義塾大学, 慶應義塾2021年度学事振興資金 研究補助, Aya Jibiki, Research grant, Principal investigator

  • グルココルチコイド誘発性糖尿病患者におけるインスリン離脱困難例の要因分析

    2019.04
    -
    2020.03

    慶應義塾大学, 慶應義塾2019年度学事振興資金 研究補助, Research grant, Principal investigator

  • Analysis of factors influencing failure of treatment with harbal medicine for menopausal symptoms

    2018.04
    -
    2021.03

    The Research Foundation for Pharmaceutical Sciences, JIBIKI　Aya, Research grant, Principal investigator

  • グルココルチコイド誘発性糖尿病に対する薬物治療の洗練化と発症予測因子の検討

    2018.04
    -
    2020.03

    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research, JIBIKI AYA, Research grant, Principal investigator

    　View Summary

    グルココルチコイド（GC）の副作用のうち、GC誘発性糖尿病に着目し、薬物治療の洗練化およびGC誘発性糖尿病の発症予測や早期発見を目指して以下の検討を行う。
    ①GC誘発性糖尿病患者の処方実態について調査し、各種糖尿病治療薬のGC誘発性糖尿病に対する有用性について検討する。
    ②GC内服患者の血中・尿中の11β-Hydroxysteroid dehydrogenase type 1（11β-HSD1）活性を測定し、GC誘発性糖尿病の発現
    群と非発現群において11β-HSD1活性に違いがあるかどうかを比較検討するとともに、11β-HSD1活性とインスリン抵抗性との間に相関があるかどうか検討し、発症予測や早期発見の指標として利用できるか否かを検証する。

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Awards 【 Display / hide 】

  • Best Presentation Award

    Aya Jibiki, Saeko Murakami, Tetsuhiro Yoshino, Yuko Horiba, Yuta Yokoyama, Hitoshi Kawazoe, Sayo Suzuki, Kenji Watanabe, Tomonori Nakamura, 2023.02, The Japanese Association for Gender-Specific Medicine, 更年期症状に対する漢方治療不応例の分析

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • RESEARCH FOR BACHELOR'S THESIS 1

    2025

  • PRIOR LEARNING FOR CLINICAL PRACTICE 3

    2025

  • PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

    2025

  • PRACTICAL LEARNING ON SUPPORTING THE HEALTH PROMOTION OF COMMUNITY

    2025

  • PHARMACY PRACTICE IN HOSPITAL & COMMUNITY PHARMACY

    2025

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Courses Previously Taught 【 Display / hide 】

  • 実務実習事前学習（実習）

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Laboratory work/practical work/exercise, Outside own faculty (within Keio), 4h, 40people

  • 実務実習事前学習３

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Outside own faculty (within Keio), 160people

    緊急情報の扱い方

  • 実務実習の前に(6)

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Outside own faculty (within Keio), 1h, 160people

  • Preclinical practice (6)

    Keio University

    2017.04
    -
    2018.03
    , 

    Spring Semester, Lecture, Outside own faculty (within Keio), 1h, 152people

    治験薬管理

  • Prior learning for clinical practice 3

    Keio University

    2017.04
    -
    2018.03
    , 

    Autumn Semester, Lecture, Outside own faculty (within Keio), 1h, 160people

    緊急情報の取り扱い

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Memberships in Academic Societies 【 Display / hide 】

  • Japanese Society of Psychosomatic Obstetrics and Gynecology, 

    2024.09
    -
    Present

  • 日本女性医学会, 

    2023.04
    -
    Present

  • 日本更年期と加齢のヘルスケア学会, 

    2022.12
    -
    Present

  • Japanese Society of Drug Safety, 

    2019
    -
    2023

  • Japan Society for Pharmaceutical Education, 

    2017
    -
    Present

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