Kobayashi, Noriko

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 医療薬学・社会連携センター　社会薬学部門 ( Shiba-Kyoritsu )

Position

Assistant Professor/Senior Assistant Professor

External Links

Academic Background 【 Display / hide 】

  • 　

    MUSASHINO UNIVERSITY, Correspondance Division Faculty of Human Studies, Department of Human Studies

    University, Graduated

  • 　

    Kyoritsu University of Pharmacy, Faculty of Pharmaceutical Science, 薬学科

    University, Graduated

  • 　

    Graduate School of Musashino University Correspondence Division, Graduate School of Human Studies, Master's Program in Human Studies

    Graduate School, Completed, Master's course

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Academic Degrees 【 Display / hide 】

  • 修士（人間学）, Musashino University, Coursework

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Books 【 Display / hide 】

  • セルフケアとOTC医薬品　改訂2版

    ネオメディカル, 2022.03

    Scope: 99-114

  • セルフケアとOTC医薬品　改訂版

    小林典子　他, ネオメディカル, 2020.03

    Scope: 消化器機能障害に伴う症状　胸やけ・胃もたれ・食欲不振、吐き気・嘔吐,  Contact page： 95-111

  • セルフケアとOTC医薬品

    KOBAYASHI Noriko, ネオメディカル, 2017.03

    Scope: 消化器機能障害に伴う症状　

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Papers 【 Display / hide 】

  • Use of Dysphagia-Inducing Drugs and Risk of Aspiration Pneumonia: A Cross-Sectional Analysis Using a Japanese Claims Database

    Hayashi N., Yoshida M., Maida N., Kondo S., Ogawa M., Iwata H., Kobayashi N., Yamaura K.

    Drugs Real World Outcomes 12 ( 4 ) 607 - 614 2025.12

    ISSN  21991154

    　View Summary

    Background and Objectives: Oropharyngeal dysphagia (OD), a dysfunction in swallowing food or drink, can result from various diseases and adverse drug reactions. OD is a risk factor for aspiration pneumonia (AP). However, the specific drugs causing OD and their incidence rates are not fully understood. This study aimed to identify drugs associated with OD, their incidence rates, and AP risk factors in patients taking these drugs on the basis of the information provided in package inserts. Methods: This study identified candidate dysphagia-inducing drugs (CDIDs) from Japanese package inserts that listed OD as an adverse reaction. The age, sex, medications, and comorbidities of patients taking CDIDs were analyzed using the JammNet insurance database, purchased from JammNet Co., Ltd. (Tokyo, Japan). Results: Overall, 54 ingredients were identified as CDIDs. Out of 24,276 patients taking CDIDs, 146 (0.6%) were diagnosed with OD and 76 (0.3%) with AP. Among those with AP, 23 patients (30%) also had OD. OD or AP occurred in patients taking 28 (52%) of the 54 target ingredients. In addition, 13 ingredients had an adverse reaction incidence of 1% or greater for either condition. The top five CDIDs with the highest incidence rates for each diagnosis were clobazam, baclofen, zonisamide, tiapride hydrochloride, and topiramate. Incidence rates of OD and AP were significantly higher with multiple CDIDs than with a single drug (p < 0.05). Logistic regression analysis showed that AP occurrence was significantly associated with males, late-stage elderly individuals, a diagnosis of OD, and constipation. Conclusions: The results of this study suggest that careful attention should be given to the risk of AP when prescribing CDIDs, particularly for elderly male patients.

  • Loneliness and analgesic overuse among low-dose estrogen-progestin users in Japan

    Fujimoto T., Iwata H., Kobayashi N., Kondo S., Yamaura K.

    BMC Women S Health 25 ( 1 )  2025.12

    　View Summary

    Purpose: Loneliness is related to menstrual disorders and medication use. Loneliness and pain are related and may be associated with analgesic use. The aim of this study was to investigate the prevalence of concomitant analgesic use and overuse, and to clarify factors associated with loneliness and analgesic overuse among women who are low-dose estrogen-progestin (LEP) users. Methods: Women in their 20s and 30s were randomly selected from a research company’s web panel (Macromill, Inc.) and LEP users were screened. The survey included analgesic concomitant use days per month and the Three-Item Loneliness Scale (TIL). Logistic regression analysis was performed with high TIL score (≥ 6) and analgesic use ≥ 10 days per month as the objective variables. Results: A total of 516 valid responses from LEP users were analyzed. Among them, 64.1% reported concomitant analgesic use on ≥ 1 day per month, 11.2% on ≥ 10 days per month, and 45.7% had high TIL score. High TIL score was significantly associated with concomitant analgesic use on ≥ 1 day per month (odds ratio [OR] 1.76, 95% confidence interval [95%CI] 1.18–2.63, p = 0.006). Concomitant analgesic use on ≥ 10 days per month was significantly associated with endometriosis (OR 5.25, 95%CI 2.15–12.81, p < 0.001) and concomitant analgesic use for low back pain (OR 4.67, 95%CI 1.65–13.18, p = 0.04). Conclusions: To our knowledge, this is the first detailed study to investigate concomitant analgesic use and overuse among LEP users. Loneliness was found to be prevalent in this population and was associated with concomitant analgesic use, potentially reflecting underlying patterns of frequent or habitual analgesic intake. Furthermore, concomitant analgesic overuse was linked to conditions such as endometriosis and low back pain, underscoring the importance of medication monitoring that takes into account both loneliness and the self-recording of menstrual symptoms. Greater attention by healthcare professionals to the psychosocial context of concomitant analgesic overuse and loneliness may facilitate more meaningful patient dialogue and contribute to improved quality of life.

  • Sex Differences in Electrolyte Disturbances Among Diuretic Users According to Renal Function and Age

    Maida N., Kondo S., Hayashi N., Iwata H., Kobayashi N., Yamaura K.

    Drug Safety 48 ( 10 ) 1149 - 1159 2025.10

    ISSN  01145916

    　View Summary

    Introduction: Diuretics are widely used in Japan for the treatment of hypertension and heart failure. Electrolyte disturbance is a common adverse reaction to diuretics and may be life-threatening. Previous studies have shown that diuretic-induced electrolyte disturbance is more common in women. Electrolyte balance is regulated by the kidneys, and renal function tends to decline with advancing age. Objective: The aim of this study was to identify patients at high risk of adverse reactions to diuretics, considering the effects of sex, renal function, and age on susceptibility to diuretic-induced electrolyte disturbance. Methods: Claims data for 67,135 patients on diuretics in Japan were sourced from DeSC Healthcare, Inc. The data covered the period from April 2020 to March 2021. Results: Analysis of patient numbers using the chi-squared test showed that hyperkalemia was more common in men than in women (326 vs. 271; p = 0.003) and that hypokalemia was more common in women than in men (413 vs. 285; p < 0.001). Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for women considering age and renal function (estimated glomerular filtration rate [eGFR]). In elderly patients aged ≥ 75 years, the odds of developing hypokalemia in women compared to men were 1.47 (95% CI 1.13–1.91) for eGFR 60–30 mL/min/1.73 m<sup>2</sup> and 2.05 (95% CI 1.08–4.10) for eGFR < 30 mL/min/1.73 m<sup>2</sup>. Conclusion: Among women aged ≥ 75 years, those in lower eGFR groups (60–30 and < 30) had higher odds of hypokalemia compared to men. These data highlight the importance of monitoring for adverse reactions to diuretics, particularly hypokalemia, in elderly women with low eGFR.

  • Identification of Issues Related to Enteral Nutrients Using a Database of Near-miss Events from Community Pharmacies

    Kondo S., Maese M., Iwata H., Kobayashi N., Yamaura K.

    Keio Journal of Medicine 74 ( 2 ) 86 - 95 2025

    ISSN  00229717

    　View Summary

    Undernutrition is a common risk after surgery or during periods when oral dietary intake is challeng-ing. Enteral nutrients, frequently utilized in nutritional management, are drugs associated with multi-ple contraindications involving pathology and allergy, and they require careful attention in dispensing. However, the occurrence of nutrition-related incidents in community pharmacies remains unknown. This study aimed to identify issues regarding the safety of pharmacotherapy in patients requiring enteral nutrition using the database of Project to Collect and Analyze Pharmaceutical Near-Miss Event Information. We highlighted the critical information that pharmacists should focus on to prevent acci-dents and elucidated the details and prescription drugs of cases that matched the search for “Nutrition (all included)” in Japanese. There were 475 cases reported between January 2009 and September 2023. Of these, 347 cases (73%) were classified as “inquiry about prescription and provision of information to prescribing physician” (Category II) and 115 cases (24%) were classified as “drug dispensing” (Cat-egory I). In both cases, the top five drugs were enteral nutrients. Among the life-threatening Category II cases, 9 cases were for pathological contraindications including severe liver or renal dysfunction, 6 cases were for adverse reactions including diarrhea, and 5 cases were for allergies or patient constitutions. Notably, the incidence of adverse reactions was higher than in data for the latest annual reports. Therefore, pharmacists should be mindful while dealing with prescriptions involving possible contrain-dications in patients requiring enteral nutrition. Pharmacists should contribute to the provision of safe pharmacotherapy by remaining vigilant against dispensing errors.

  • 学習成果基盤型の薬学教育モデル・コア・カリキュラムに基づく実務実習の先導から実装後の取り組み評価

    河添 仁，岩田 紘樹，石川 春樹，近藤 憐吾，地引 綾，横山 雄太，小林 典子，鈴木 小夜，山浦 克典，中村 智徳

    医療薬学 50 ( 9 ) 455 - 464 2024.09

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • コロナ禍における薬学部の状況

    小林典子

    慶應義塾大学学生部　学生相談室紀要  2021

    Other, Single Work

  • 薬学部における健康つくり教室

    小林典子

    慶應義塾大学学生部　学生相談室紀要  2019

    Other, Single Work

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Presentations 【 Display / hide 】

  • 対人援助コミュニケーションの項目を導入した実習の学修効果と課題の解明

    大形 親良、小林 典子、岩田 紘樹、近藤 慎吾、山浦 克典

    [Domestic presentation]  日本薬学会第145年会 (福岡) , 

    2025.03
    , 

    Poster presentation, 日本薬学会

  • 販売情報提供活動ガイドラインQ&A発出後の製薬企業の対応方針

    山浦 克典、三間 琳々香、近藤 慎吾、岩田 紘樹、小林 典子、渡邊 伸一

    [Domestic presentation]  日本薬学会第145年会 (福岡) , 

    2025.03
    , 

    Oral presentation (general), 日本薬学会

  • 薬局主催健康イベントによる脳卒中の病識及び受診行動に対する改善効果

    岩田 紘樹、岡﨑 光洋、近藤 慎吾、小林 典子、山浦 克典

    [Domestic presentation]  日本薬学会第145年会 (福岡) , 

    2025.03
    , 

    Poster presentation, 日本薬学会

  • 口腔ケアに対する国民の認識及びドラッグストアでの相談実態とニーズの解明

    染谷 美紗貴、岩田 紘樹、近藤 慎吾、小林 典子、山浦 克典

    [Domestic presentation]  日本薬学会第145年会 (福岡) , 

    2025.03
    , 

    Poster presentation, 日本薬学会

  • 日本と米国における医薬品添付文書の性差情報に関する記載内容の比較

    間井田 成美、濱崎 冬馬、乙黒 泉音、近藤 慎吾、岩田 紘樹、小林 典子、川本 嘉子、山浦 克典

    [Domestic presentation]  第18回 日本性差医学・医療学会学術集会 (熊本) , 

    2025.01
    , 

    Poster presentation, 日本性差医学・医療学会

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Courses Taught 【 Display / hide 】

  • RESEARCH FOR BACHELOR'S THESIS 1

    2025

  • PRIOR LEARNING FOR CLINICAL PRACTICE 5

    2025

  • PRIOR LEARNING FOR CLINICAL PRACTICE 1

    2025

  • PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

    2025

  • PRACTICAL LEARNING ON SUPPORTING THE INTELLECTUALLY DISABLED PERSON'S ACTIVITIES

    2025

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