Kizaki, Hayato



Faculty of Pharmacy, Department of Pharmacy 医薬品情報学講座 (Shiba-Kyoritsu)


Research Associate/Assistant Professor/Instructor

Career 【 Display / hide

  • 2018.11

    慶應義塾大学薬学部, 医薬品情報学講座, 助教

Academic Background 【 Display / hide

  • 2010.04

    The University of Tokyo, 薬学部, 薬科学科

    University, Graduated

  • 2014.04

    The University of Tokyo, 薬学系研究科, 薬科学専攻

    Graduate School, Completed, Master's course

  • 2016.09

    The University of Tokyo, 薬学系研究科, 薬科学専攻

    Graduate School, Doctoral course

  • 2017.09

    The University of Tokyo, 薬学系研究科, 薬学専攻

    Graduate School, Doctoral course

Academic Degrees 【 Display / hide

  • 薬科学(修士), The University of Tokyo, Coursework, 2016.03


Licenses and Qualifications 【 Display / hide

  • 東京大学フューチャーファカルティプログラム修了, 大学教員としてのキャリアを進むにあたり不可欠となる教育力の向上をめざすプログラム, 2017.03

  • 薬剤師免許, 2019


Research Areas 【 Display / hide

  • Life Science / Clinical pharmacy

  • Life Science / Medical management and medical sociology

Research Keywords 【 Display / hide

  • 介護施設

  • 医療安全

  • 医薬品情報

  • 多職種連携

  • 薬剤師


Papers 【 Display / hide

  • Adverse event signal extraction from cancer patients’ narratives focusing on impact on their daily-life activities

    Nishioka S., Asano M., Yada S., Aramaki E., Yajima H., Yanagisawa Y., Sayama K., Kizaki H., Hori S.

    Scientific Reports (Scientific Reports)  13 ( 1 ) 15516 2023.12

     View Summary

    Adverse event (AE) management is important to improve anti-cancer treatment outcomes, but it is known that some AE signals can be missed during clinical visits. In particular, AEs that affect patients’ activities of daily living (ADL) need careful monitoring as they may require immediate medical intervention. This study aimed to build deep-learning (DL) models for extracting signals of AEs limiting ADL from patients’ narratives. The data source was blog posts written in Japanese by breast cancer patients. After pre-processing and annotation for AE signals, three DL models (BERT, ELECTRA, and T5) were trained and tested in three different approaches for AE signal identification. The performances of the trained models were evaluated in terms of precision, recall, and F1 scores. From 2,272 blog posts, 191 and 702 articles were identified as describing AEs limiting ADL or not limiting ADL, respectively. Among tested DL modes and approaches, T5 showed the best F1 scores to identify articles with AE limiting ADL or all AE: 0.557 and 0.811, respectively. The most frequent AE signals were “pain or numbness”, “fatigue” and “nausea”. Our results suggest that this AE monitoring scheme focusing on patients’ ADL has potential to reinforce current AE management provided by medical staff.

  • Influence of Participation in a Medical-Themed Science Café on Patient Activation

    Okazawa Y., Kizaki H., Suzuki N., Osaka W., Hori S.

    Patient Preference and Adherence (Patient Preference and Adherence)  17   3093 - 3106 2023.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1177-889X

     View Summary

    Purpose: This study aims to investigate the impact of a Science Café (SC) dealing with medical topics on participants’ patient activation (PA), a concept that refers to patients’ involvement in managing their own health, working with their healthcare providers, and maintaining their health. Material and Methods: Semi-structured interviews were conducted with patients who had participated in a medical SC (n = 10) to identify the medical SC-associated factors that influenced PA. Through a questionnaire of medical SC participants (n = 23), the impact on PA and correlations with relevant psychological measures were quantitatively assessed. Results: The interviews revealed three factors: “Experience & acceptance of chronic conditions”, “Features of medical SC” and “Changes as a result of participation.” The questionnaire results showed a positive correlation between PA and resilience and a negative correlation with decision regret. Conclusions: Participation in a medical SC by people with illnesses can improve PA by improving knowledge and skills for self-management and increasing self-awareness of illness in a supportive environment. The study highlights the potential benefits of using medical SC as a strategy for healthcare providers to improve PA and health outcomes.

  • Comparison of different sustained-release opioids and acute respiratory conditions in patients with cancer and chronic kidney disease

    Mitsuboshi S., Imai S., Kizaki H., Hori S.

    Pharmacotherapy (Pharmacotherapy)   2023.11

    Research paper (scientific journal), Accepted,  ISSN  02770008

     View Summary

    Study Objective: Few data are available on the association between the use of oxycodone in patients with chronic kidney disease (CKD) and acute respiratory conditions. The aim of this study was to investigate whether oxycodone is associated with an increased risk of acute respiratory conditions in patients with cancer and CKD compared with other opioids. Design and Setting: The data were obtained from a claims database in Japan. Patients with cancer and CKD who had received sustained-release opioids, including oral oxycodone, oral morphine, or transdermal fentanyl, between April 2014 and May 2021 were selected. The primary outcome was defined as an acute respiratory condition. Data for age and sex, morphine equivalent daily dose, concomitant use of specified medications, comorbidities defined based on the modified Charlson comorbidity index, substance use disorder, and lung cancer or metastatic lung cancer were investigated as covariates. Distribution of acute respiratory conditions was compared among the three sustained-release opioid groups using the log-rank test. Estimates of the incidence of acute respiratory conditions were compared among the groups using a Cox proportional hazards model with time-varying variables. Main Results: A significant difference in the distribution of acute respiratory conditions was found among the three groups (p < 0.01). Cox regression analysis showed a significantly higher risk of acute respiratory conditions with morphine (hazard ratio [HR]: 3.04, 95% confidence interval [CI]: 1.07–8.65, p = 0.04) compared with oxycodone but no significant difference in risk with oxycodone (HR 0.67, 95% CI: 0.32–1.38, p = 0.27) compared with fentanyl. Conclusions: The findings suggest that the risk of acute respiratory conditions may be lower in patients with CKD who use oxycodone for cancer pain than in those who use morphine. Additionally, no difference in the risk of acute respiratory conditions was found between oxycodone and fentanyl use.

  • Influence of Voiced and Semi-voiced Sounds on the Subjective Similarity of Different Drug Names: A Cognitive Psychological Experiment

    Yoshikawa K., Kizaki H., Imai S., Hori S.

    Biological and Pharmaceutical Bulletin (Biological and Pharmaceutical Bulletin)  46 ( 11 ) 1630 - 1634 2023.11

    ISSN  09186158

     View Summary

    The similarity of drug names is one of the common causes of medication error. In Japan, similarity evaluation is performed prior to approval of new drugs in order to avoid potential confusion. However, existing indices do not take account of the difference between characters that contain voiced or semi-voiced and unvoiced sounds, so it is not clear whether such sounds influence the subjective similarity of drug names. Thus, we performed a cognitive psychological experiment to investigate this issue, using participants who had not received any education in medicine, nursing, or pharmacy. An analogue scale questionnaire was used to evaluate the subjective similarity of the names of drug pairs. Drug pairs for the main analysis were prepared by matching the first 0 to 3 characters, and then varying the difference in the number of voiced and semi-voiced characters from 0 to 3 in these matched characters. By means of this procedure, the drug pairs were classified into a total of 10 groups. Then, a total of 60 drug pairs were created by assigning 6 drugs to each group. The subjective similarity tended to increase with increasing number of common characters among the first three characters. When classified according to the number of these common characters, the subjective similarity was significantly decreased when voiced or semi-voiced sounds were present, as compared with when they were absent. These results indicate that a new drug name similarity index that takes account of voiced and semi-voiced sound differences should be developed to minimize medication errors.

  • A Survey of the Status of Methadone Switching in Japan Using a Hospital-Based Administrative Claims Database

    Imai S., Aoki N., Ikegami K., Kizaki H., Hori S.

    Journal of Clinical Pharmacology (Journal of Clinical Pharmacology)   2023.09

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  00912700

     View Summary

    Methadone is generally used for the management of cancer pain in patients who cannot obtain adequate analgesia from other strong opioids; however, it has a complicated and inconsistent conversion ratio from pre-switching opioid dosage to methadone. This issue may be pronounced in Japan because only oral tablets are commercially available. We aimed to elucidate the status of methadone switching in Japan, focusing on its dosage. Using a Japanese hospital-based administrative claims database, we included patients who switched to methadone between April 2008 and January 2021. The proportion of methadone switching completion that required more than the defined conversion ratio in the Japanese package insert (called “high-dose methadone switching”) was evaluated as a primary endpoint. Other endpoints included “the duration from initiation to completion of methadone switching” and “factors affecting high-dose methadone switching by using multivariate logistic regression analysis”. Of 1585 patients who received methadone, 370 were enrolled. Among those, 130 (35.1%) received high-dose methadone switching. The median duration of methadone switching completion (12 days) was longer in the high-dose methadone switching group than in other patients. Four variables were identified as factors affecting high-dose methadone switching. Younger age and outpatient status increased the risk of requiring high-dose methadone switching, whereas the concomitant use of nonsteroidal anti-inflammatory drugs and fentanyl as a pre-switching opioid decreased the risk. In conclusion, more than 30% of the patients underwent high-dose methadone switching and required long completion periods, suggesting that methadone switching remains challenging in Japan.

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 新薬まるわかり アルツハイマー型認知症治療薬 アリドネパッチ 27.5mg/55mg (ドネペジル)

    木崎速人,名倉慎吾,佐藤宏樹,三木晶子著 堀 里子,澤田康文監.

    日経ドラッグインフォメーション ( 日経BP社)  315 2024.01

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

  • 新薬まるわかり 骨粗鬆症治療薬 オスタバロ皮下注カートリッジ 1.5mg (アバロパラチド酢酸塩)

    木崎速人,名倉慎吾,佐藤宏樹,三木晶子著 堀 里子,澤田康文監.

    日経ドラッグインフォメーション ( 日経BP社)  313 2023.11

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

  • 新薬まるわかり 抗リウマチ薬 メトジェクト皮下注 7.5mgシリンジ0.15mL/10mgシリンジ0.20mL/12.5mgシリンジ0.25mL/15mgシリンジ0.30mL (メトトレキサート)

    木崎速人,中田雄大,佐藤宏樹,三木晶子著 堀 里子,澤田康文監.

    日経ドラッグインフォメーション ( 日経BP社)  311 2023.11

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

  • 新薬まるわかり 片頭痛治療剤5-HT1F 受容体作動薬薬 レイボー錠 50mg/100mg(ラスミジタンコハク酸塩)

    木崎速人,鈴木則子,佐藤宏樹,三木晶子著 堀 里子,澤田康文監.

    日経ドラッグインフォメーション ( 日経BP社)  309 2023.07

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

  • 新薬まるわかり 非ステロイド型選択的MR拮抗薬 ケレンディア錠 10mg/20mg(フィネレノン)

    木崎速人,鈴木則子,佐藤宏樹,三木晶子著 堀 里子,澤田康文監.

    日経ドラッグインフォメーション ( 日経BP社)  307 2023.05

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

display all >>

Presentations 【 Display / hide

  • 腎細胞がん患者に対するチロシンキナーゼ阻害薬誘発性高血圧 の発現に関する実態調査及び関連因子の検討

    中西慧,池上慶祐,今井俊吾, 木﨑速人,堀里子.



    Poster presentation

  • 正則化ロジスティック回帰/LightGBMを用いた服薬状況に対する服薬アドヒアランス素因の関連性解析及び重要度の検討



    Oral presentation (general)

  • External Validation and Update of the Risk Prediction Model of Denosumab-Induced Hypocalcemia Developed from Medical Big Data for Clinical Use.

    Keisuke Ikegami, Shungo Imai, Osamu Yasumuro, Masami Tsuchiya, Naomi Henmi, Mariko Suzuki, Katsuhisa Hayashi, Chisato Miura, Haruna Abe, Hayato Kizaki, Ryohkan Funakoshi, Yasunori Sato, Satoko Hori.

    FAPA 2023 (台湾) , 


    Poster presentation

  • 自然言語処理モデルBERTを用いた医薬品関連インシデント要因抽出のためのマルチラベル分類器の構築



    Poster presentation

  • 電子お薬手帳を基盤としたPHR活用による,「薬を大きくて飲みづらいと感じる」患者の予測モデル構築

    淺野 真輝,今井 俊吾,清水 友梨,木﨑 速人,吉田 奈央,島田 昌典,山東 崇紀,石島 知,堀 里子.



    Poster presentation

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 要介護等高齢者の薬物治療適正化・医療安全確保に向けた介護施設における医薬品関連インシデント事例の要因解析


    日本医薬品情報学会, 課題研究班, No Setting, Principal investigator

Awards 【 Display / hide

  • 第21介医薬品情報学会・学術大会 学生優秀発表ポスター賞

    木崎速人,佐藤宏樹,山本大輔,馬来秀行,益子幸太郎,小西ゆかり,浅井康平,堀里子,澤田康文, 2018.06, 医薬品情報学会, 介護士による服薬介助に伴い発生したインシデントに関する記述疫学的解析

    Type of Award: Award from Japanese society, conference, symposium, etc.


Courses Taught 【 Display / hide











display all >>

Courses Previously Taught 【 Display / hide

  • 実務実習事前学習(実習)

    Keio University


    Autumn Semester, Laboratory work/practical work/exercise, 160people

Educational Activities and Special Notes 【 Display / hide

  • 明治大学 「教職実践演習」:「教育実習の総まとめ」、授業題目:正しい薬の育て方


    , Special Affairs

  • 東京大学教養学部 全学自由研究ゼミナール「伝えるを学ぼう」:第6回「大学院生による模擬授業・検討・解説3」、授業題目:創る薬から育てる薬へ


    , Special Affairs

  • 学校法人河合塾 知の追究講座 講師:「薬の創り方・育て方〜薬学研究の最前線〜」


    , Special Affairs

  • 東京大学文学部 第1回留学生ワークショップ 講師:「何気ない日本人の習慣・考え方を学ぼう!」


    , Special Affairs

  • 学校法人河合塾 学びみらいプログラム 講師:「正しい薬の育て方」


    , Special Affairs


Memberships in Academic Societies 【 Display / hide

  • 日本薬学会, 

  • 医薬品情報学会

  • 医療薬学会


Committee Experiences 【 Display / hide

  • 2020.04

    研究企画委員会 委員, 一般財団法人 日本医薬品情報学会