Uekusa, Yoshinori

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 天然医薬資源学講座 （Shiba-Kyoritsu）

Position

Research Associate/Assistant Professor/Instructor

External Links
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Career 【 Display / hide 】

  • 2016.07
    -
    Present

    Keio University, Faculty of Pharmacy, Assistant Professor

  • 2016.07
    -
    Present

    National Institute of Health Sciences, Division of Foods, 協力研究員

  • 2019.10
    -
    2020.08

    Scripps Institution of Oceanography, University of California, San Diego, Center for Marine Biotechnology and Biomedicine, Visiting Scholar

  • 2013.05
    -
    2016.06

    National Institute of Health Sciences, Division of Foods, technical official, Researcher

  • 2013.04

    Nagoya City University, Graduate School of Pharmaceutical Sciences, Postdoctoral Fellow

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Academic Background 【 Display / hide 】

  • 2007.04
    -
    2010.03

    University of Shizuoka, Department of Food and Nutritional Sciences, 食品栄養科学専攻

    Graduate School, Completed, Doctoral course

  • 2005.04
    -
    2007.03

    University of Shizuoka, Department of Food and Nutritional Sciences, 食品栄養科学専攻

    Graduate School, Completed, Master's course

  • 2001.04
    -
    2005.03

    Tokyo University of Pharmacy and Life Science, School of Life Sciences, 分子生命科学科

    Graduated

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Academic Degrees 【 Display / hide 】

  • 博士（食品栄養科学）, University of Shizuoka, Coursework, 2010.03

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Research Areas 【 Display / hide 】

  • Natural medicines (Natural Product Chemistry)

  • Analytical chemistry (Analytical Chemistry)

  • Food science (Food Chemistry)

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Research Keywords 【 Display / hide 】

  • Analytical Chemistry

  • Natural Product Chemistry

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Books 【 Display / hide 】

  • 試料分析講座 糖質分析

    植草 義徳, 丸善出版, 2019.07

    Scope: 6.4 NMR による糖鎖–タンパク質相互作用の解析,  Contact page： 246–252

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Papers 【 Display / hide 】

  • Anti-trypanosome screening of Salvadoran flora

    Castillo, U. G., Komatsu, A., Martínez, M. L., Menjívar, J., Núñez, M. J., Uekusa, Y., Narukawa, Y., Kiuchi, F., Nakajima-Shimada, J.

    J. Nat. Med.  2021

    Research paper (scientific journal), Joint Work, Accepted

  • Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2

    Christy, M. P., Uekusa, Y., Gerwick, L., Gerwick, W. H.

    Journal of Natural Products 84 （ 1 ） 162 - 182 2020.12

    Research paper (scientific journal), Joint Work, Accepted

  • Continuous Estimation of Annual Committed Effective Dose of Radioactive Cesium by Market Basket Study in Japan from 2013 to 2019 after Fukushima Daiichi Nuclear Power Plant Accident.

    Nabeshi H, Tsutsumi T, Imamura M, Uekusa Y, Hachisuka A, Matsuda R, Teshima R, Akiyama H

    Food safety (Tokyo, Japan) 8 （ 4 ） 97 - 114 2020.12

    Research paper (scientific journal), Joint Work, Accepted

  • Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides.

    Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides.

    Journal of Agricultural and Food Chemistry  2020.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0021-8561

  • Solubility enhancement of berberine–baicalin complex by the constituents of Gardenia Fruit

    Okoshi, K., Uekusa, Y., Narukawa, Y., Kiuchi, F.

    Journal of Natural Medicines （Journal of Natural Medicines)  75 （ 1 ） 76 - 83 2020.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  13403443

    　View Summary

    © 2020, The Japanese Society of Pharmacognosy. A Kampo prescription usually consists of several crude drugs and contains many kinds of compounds. Physicochemical interactions between the compounds may occur in the process of decoction, by which Kampo prescriptions are usually prepared for ingestion, and the interactions may change the extraction yields of the constituents. Berberine and baicalin have been reported to form precipitates. Orengedokuto, which consist of Coptis Rhizome, Gardenia Fruit, Phellodendron Bark and Scutellaria Root, has been a representative Kampo prescription used to treat inflammatory diseases. In our previous papers, we revealed that the precipitates formed in the decoction of orengedokuto without Gardenia Fruit mainly consists of berberine–baicalin complex and that Gardenia Fruit reduced the amount of the precipitates in orengedokuto decoction. In this report, through solubility-enhancement assay based on HPLC, we identified crocins as the constituents of Gardenia Fruits, which enhanced the solubility of berberine–baicalin complex. All-trans crocin-1 (1) and 13-cis crocin-1 (5) showed high activities among the isolated crocins, and the number of glucosyl groups in the molecule seemed correlated with the activity. As berberine and baicalin were reported as the anti-inflammatory constituents of Coptis Rhizome and Phellodendron Bark, and Scutellaria Root, respectively, Gardenia Fruit contributes anti-inflammatory activity of orengedokuto by increasing solubilities of anti-inflammatory constituents of the other component crude drugs in the prescription. Our result will add a scientific basis to the understanding of the effectiveness of orengedokuto as a whole.

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 多成分系から相乗作用に関与する化合物を探し出す

    UEKUSA Yoshinori

    ファルマシア 54 ( 10 ) 982 2018.10

    Introduction and explanation (scientific journal), Single Work

  • NMR characterization of the conformations, dynamics, and interactions of glycosphingolipids

    Yagi-Utsumi, M., Yamaguchi, Y., Uekusa, Y., and Kato, K.

    NMR in Glycoscience and Glycotechnology (RSC Publishing (Cambridge))     161 - 178 2017.05

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • NMR を用いたテアフラビン類によるリポソーム凝集作用の解明

    第17回日本カテキン学会年次学術大会, 2021.12, Oral Presentation(general)

  • Development of peptide alkaloid-type compound library based on brefeldin A by molecular skeleton recombination strategy

    13th AFMC International Medicinal Chemistry Symposium, 2021.11, Poster (general)

  • 栄養源バクテリアの変化による細胞性粘菌由来新規二次代謝産物の探索

    日本細胞性粘菌学会第11回例会, 2021.10, Oral Presentation(general)

  • テアフラビン類とリン脂質膜との分子間相互作用解析

    陳瀟逸，植草義徳，中山勉，木内文之，菊地晴久

    日本生薬学会第67回年会, 2021.09, Poster (general)

  • 分子ネットワークを用いたシアノバクテリア由来の新規化合物の単離

    小川慧人，植草義徳，木内文之，William H. Gerwick，菊地晴久

    第65回日本薬学会関東支部大会, 2021.09, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 温泉藻のもつ有用天然物の網羅的探索

    2021.10
    -
    2022.09

    公益財団法人　戸部眞紀財団, 研究助成, 岩崎有紘, Research grant, Co-investigator

  • ビッグデータと人工知能を活用した熱帯病治療薬候補物質の探索

    2021.04
    -
    2022.03

    慶應義塾大学, 2021年度学事振興資金（部門横断型共同研究）, 岩崎有紘, Research grant, Co-investigator

  • 分子ネットワークを利用した多成分系における化合物間相互作用の解析

    2021.04
    -
    2022.03

    慶應義塾大学, 福澤諭吉記念基金, Research grant, Principal Investigator

  • ゲノムマイニングを活用した新規天然化合物の効率的な探索

    2021.04
    -
    2022.03

    慶應義塾大学, 学事振興基金（個人研究）, Research grant, Principal Investigator

  • 難培養性シアノバクテリア由来新規天然有機化合物の探索・合成展開 による創薬基盤構築

    2021
    -
    2024

    日本学術振興会, 科学研究費補助金 国際共同研究加速基金（国際共同研究強化（B））, 吉田将人, Research grant, Co-investigator

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Awards 【 Display / hide 】

  • Poster Award, The 65th Annual Meeting of the Japanese Society of Pharmacognosy

    2018.09, Structural analysis of the baicalin–berberine complex in water

  • Encouragement Award in Japanese Society of Food Chemistry

    2016.06, 日本食品化学学会, 東日本大震災に起因した食品中の有害物質等の実態に関する研究

  • Young Investigator Award

    2009.11, 日本フードファクター学会, NMR法による緑茶カテキン類のリン脂質膜中における存在位置の解明

  • 第18回フードサイエンスフォーラム　最優秀プレゼンテーション賞

    2008.11, フードサイエンスフォーラム, ECgの脂質膜中における動態挙動解析（固体NMRによる相互作用解析）

  • 第17回フードサイエンスフォーラム　最優秀プレゼンテーション賞

    2008.03, フードサイエンスフォーラム, 茶カテキン類は生体膜（脂質二重層）の表面と相互作用する（溶液NMRを用いた相互作用部位の解析）

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Courses Taught 【 Display / hide 】

  • STUDY OF MAJOR FIELD: (NATURAL MEDICINES)

    2021

  • SEMINAR: (NATURAL MEDICINES)

    2021

  • RESEARCH FOR BACHELOR'S THESIS 1

    2021

  • PHARMACOGNOSY LABORATORY COURSE

    2021

  • PHARMACOGNOSY 2

    2021

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Courses Previously Taught 【 Display / hide 】

  • Molecular design of medicine

    Keio University, 2017, Spring Semester

  • Structural analysis of biological molecules and bioactive compounds

    Keio University, 2017, Spring Semester

  • Advanced natural products chemistry

    Keio University, 2017, Spring Semester

  • Pharmacognosy laboratory course

    Keio University, 2017, Autumn Semester

  • Basic pharmaceutical sciences laboratory course

    Keio University, 2017, Autumn Semester

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Memberships in Academic Societies 【 Display / hide 】

  • The Pharmaceutical Society of Japan

    　

  • The Japanese Society of Pharmacognosy

    　

  • Japanese Society of Food Chemistry

    　

  • Japanese Society for Food Hygiene and Safety

    　

  • Japanese Society of Catechinology, 

    2021
    -
    Present
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