Papers - Imaoka, Ayuko

The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.

Hiroki Kataoka, Takeshi Akiyoshi, Yasuo Uchida, Ayuko Imaoka, Tetsuya Terasaki, Hisakazu Ohtani

J Pharm Sci. 113 ( 5 ) 1376 - 1384 2024

Research paper (scientific journal), Joint Work, Accepted

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro.

Kojima M, Machida K, Cho S, Watanabe D, Seki H, Shimoji M, Imaoka A, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Akiyoshi T, Ohtani H.

Xenobiotica. 53 ( 5 ) 357 - 365 2023

Research paper (scientific journal), Joint Work, Accepted

Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.

Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.

J Pharmacol Sci. 153 ( 3 ) 153 - 160 2023

Research paper (scientific journal), Joint Work, Accepted

The effects of jabara juice on the intestinal permeation of fexofenadine.

Han H, Akiyoshi T, Morita T, Tsuchitani T, Nabeta M, Yajima K, Imaoka A, Ohtani H.

Biol Pharm Bull. 46 ( 12 ) 1745 - 1752 2023

Research paper (scientific journal), Joint Work, Accepted

Irinotecan-induced gastrointestinal damage alters the expression of peptide transporter 1 and absorption of cephalexin in rats.

Imaoka A, Hattori T, Akiyoshi T, Ohtani H.

Biopharm Drug Dispos. 44 ( 5 ) 372 - 379 2023

Research paper (scientific journal), Joint Work, Lead author, Accepted

Evaluation of hepatic CYP3A4 enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone and aprepitant.

Hibino H, Sakiyama N, Makino Y, Makihara-Ando R, Horinouchi H, Fujiwara Y, Kanda S, Goto Y, Yoshida T, Okuma Y, Shinno Y, Murakami S, Hashimoto H, Akiyoshi T, Imaoka A, Ohe Y, Yamaguchi M, Ohtani H.

Eur J Clin Pharmacol.  2022

Research paper (scientific journal), Joint Work, Accepted

Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract--Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up-.

Tsuchitani T, Akiyoshi T, Imaoka A, Ohtani H.

Int J Clin Pharmacol Ther. 60 ( 5 ) 217 - 224 2022

Research paper (scientific journal), Joint Work, Accepted

Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants.

Araki N, Morita T, Akiyoshi T, Kataoka H, Yajima K, Katayama K, Imaoka A, Ohtani H.

Drug Metab Pharmacokinet. 46   100464 2022

Research paper (scientific journal), Joint Work, Accepted

Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants.

Han H, Akiyoshi T, Morita T, Kataoka H, Katayama K, Yajima K, Imaoka A, Ohtani H.

Drug Metab Pharmacokinet.  46 2022

Research paper (scientific journal), Joint Work, Accepted

Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient.

Hibino H, Makino Y, Sakiyama N, Makihara-Ando R, Hashimoto H, Akiyoshi T, Imaoka A, Fujiwara Y, Ohe Y, Yamaguchi M, Ohtani H.

Int J Clin Pharmacol Ther.  2021

Research paper (scientific journal), Joint Work, Accepted

Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resAnalysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol.veratrol.

Akiyoshi T, Uchiyama M, Inada R, Imaoka A, Ohtani H.

Drug Metab Pharmacokinet.  2021

Research paper (scientific journal), Joint Work, Accepted

Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants

Akiyoshi T, Naitou R, Imaoka A, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H.

Int J Pharmacol Ther. 59 ( 12 ) 745 - 752 2021

Research paper (scientific journal), Joint Work, Accepted

Digoxin absorption decreased independency of P-gp activity in rats with irinotecan-induced gastrointestinal damage.

Tsuchitani T, Akiyoshi T, Imaoka A, Ohtani H.

J Pharm Health Care Sci.  2021

Research paper (scientific journal), Joint Work, Accepted

Estimation of absolute oral bioavailability without performing an intravenous clinical study.

Ohtani H, Iwata R, Imaoka A, Akiyoshi T.

Drug Metab Pharmacokinet.   2021

Research paper (scientific journal), Joint Work, Accepted

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants.

Yamaguchi Y, Akiyoshi T, Kawamura G, Imaoka A, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H

Drug Metab Pharmacokinet.  2021

Research paper (scientific journal), Joint Work, Accepted

pH-dependent transport kinetics of the human organic anion transporting polypeptide 1A2.

Drug Metabolism and Pharmacokinetics 35 ( 2 ) 220 - 227 2020

Research paper (scientific journal), Joint Work, Accepted

医薬品の第三者への転売・譲渡の違法性に関する消費者の意識調査

医薬品情報学 22 ( 1 )  2020

Research paper (scientific journal), Joint Work, Accepted

The citrus fruit-derived flavanone glycoside narirutin is a novel potent inhibitor of organic anion-transporting polypeptides.

Morita T, Akiyoshi T, Sato R, Uekusa Y, Katayama K, Yajima K, Imaoka A, Sugimoto Y, Kiuchi F, Ohtani H.

J Agric Food Chem.  2020

Research paper (scientific journal), Joint Work, Accepted

Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies - validation using an in silico approach -.

Koinuma K, Tsuchitani T, Imaoka A, Akiyoshi T, Ohtani H.

Int J Clin Pharmacol Ther.  2020

Research paper (scientific journal), Joint Work, Accepted

Novel method to estimate the appropriate dosing interval for activated charcoal to avoid drug interaction with other drugs.

Ohtani H, Nakamura K, Imaoka A, Akiyoshi T.

Eur J Clin Pharmacol. 76 ( 11 ) 1529 - 1536 2020

Research paper (scientific journal), Joint Work, Accepted

Profile of the inhibitory effects of gefitinib on CYP2D6 variants in vitro.

Semba Y, Akiyoshi T, Hibino H, Imaoka A, Ohtani H.

Int J Clin Pharmacol Ther. 58 ( 10 ) 539 - 542 2020

Research paper (scientific journal), Joint Work, Accepted

インターネットオークションにおける無承認無許可医薬品の出品実態

大谷 壽一, 藤井 萌未, 今岡 鮎子, 秋好 健志

医療薬学 45 ( 10 ) 591 - 595 2019.10

Research paper (scientific journal), Joint Work, Accepted

Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats.

Ogata Y, Imaoka A, Akiyoshi T, Ohtani H.

Drug Metab Pharmacokinet.   2019

Research paper (scientific journal), Joint Work, Accepted

Inhibitory kinetics of fruit components on CYP2C19 activity.

Seki H, Akiyoshi T, Imaoka A, Ohtani H.

Drug Metab Pharmacokinet. 34 ( 3 ) 181 - 186 2019

Research paper (scientific journal), Joint Work, Accepted

Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate

Hattori T, Imaoka A, Akiyoshi T, Ohtani H.

Biopharmaceutics & Drug Disposition  2019

Research paper (scientific journal), Joint Work, Accepted

5-Fluorouracil-Induced Gastrointestinal Damage Impairs the Absorption and Anticoagulant Effects of Dabigatran Etexilate.

Tsujii K, Hattori T, Imaoka A, Akiyoshi T, Ohtani H.

Journal of pharmaceutical sciences 107 ( 5 ) 1430 - 1433 2018

Research paper (scientific journal), Joint Work, Accepted

Food intake attenuates the drug interaction between new quinolones and aluminum.

Imaoka A, Abiru K, Akiyoshi T, Ohtani H.

Journal of Pharmaceutical Health Care and Sciences 4 2018

Research paper (scientific journal), Joint Work, Accepted

The extent of drug-drug interaction between amlodipine and activated acharcoal is attenuated by food intake in rats.

Imaoka A, Seki K, Akiyoshi T, Ohtani H.

Drug Metabolism and Pharmacokinetics  2018

Research paper (scientific journal), Joint Work, Accepted

Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan.

Ohtani H, Mitsui R, Akiyoshi T, Imaoka A, Abe Y, Kanke M, Nakamura T, Foster P, Mochizuki M.

Curr Pharm Teach Learn 9 ( 3 ) 452 - 459 2017

Research paper (scientific journal), Joint Work, Accepted

Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin.

Ishikawa Y, Akiyoshi T, Imaoka A, Ohtani H.

Biopharmaceutics & Drug Disposition 38 ( 7 ) 420 - 425 2017

Research paper (scientific journal), Joint Work, Accepted

5-Fluorouracil treatment alters the expression of intestinal transporters in rats.

Yotsumoto K, Akiyoshi T, Wada N, Imaoka A, Ohtani H.

Biopharmaceutics & Drug Disposition 38 ( 9 ) 509 - 516 2017

Research paper (scientific journal), Joint Work, Accepted

In silico evaluation of warfarin-bucolome therapy.

Ohtani H, Hakoda R, Imaoka A, Akiyoshi T

Biopharmaceutics & Drug Disposition 37   232 - 242 2016

Research paper (scientific journal), Joint Work, Accepted

Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6.

Drug Metabol Pharmacokinet 30 ( 4 ) 321 - 324 2015

Research paper (scientific journal), Joint Work

常用量以下の曝露量における全身性副作用の用量依存性の推定

三井梨恵子, 秋好健志, 今岡鮎子, 望月眞弓, 大谷壽一.

医薬品情報学 17 ( 2 ) 77 - 86 2015

Research paper (scientific journal), Joint Work, Accepted

インターネットオークションでの違法な医薬品取引と主催者による監視、削除の実態

大谷壽一, 今岡鮎子, 秋好健志.

薬学雑誌 135 ( 3 ) 529 - 534 2015

Research paper (scientific journal), Joint Work, Accepted

Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption.

Imaoka A, Hattori M, Akiyoshi T, Ohtani H.

Drug Metabolism and Pharmacokinetics 29 ( 5 ) 414 - 418 2014.10

Research paper (scientific journal), Joint Work, Accepted

Prediction of the extent and variation of grapefruit juice-drug interactions from the pharmacokinetic profile in the absence of grapefruit juice.

Kogure N, Akiyoshi T, Imaoka A, Ohtani H

Biopharmaceutics & Drug Disposition 35   373 - 381 2014.06

Research paper (scientific journal), Joint Work, Accepted