Papers - Imaoka, Ayuko

Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity.

Takeshi Akiyoshi, Arun Kumar Tonduru, Hiroki Kataoka, Tokio Morita, Kodai Yajima, Ayuko Imaoka, Kazuhiro Katayama, Prasanthi Medarametla, Yasuo Uchida, Antti Poso, Hisakazu Ohtani, Tetsuya Terasaki

Drug Metab Dispos. 53 ( 12 ) 100198 2025.12

Joint Work, Accepted

Inhibition kinetics of citrus jabara juice and its components on CYP2C9 activity.

Koinuma K, Morita T, Uekusa Y, Kikuchi H, Imaoka A, Akiyoshi T, Ohtani H.

J Pharm Sci. 114 ( 11 ) 103983 2025.09

Research paper (scientific journal), Joint Work, Accepted

Comparative analysis of the single-molecule transport kinetics of OATP1B1 genetic variants.

Tsujii K, Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.

J Pharmacol Sci. 158 ( 3 ) 166 - 171 2025.07

Research paper (scientific journal), Joint Work, Accepted

Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components.

Koinuma K, Noto K, Morita T, Uekusa Y, Kikuchi H, Shimoji M, Seki H, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Imaoka A, Akiyoshi T, Ohtani H.

J Pharm Sci. 114 ( 2 ) 849 - 856 2025

Joint Work, Accepted

The effect of organic solvents on the in vitro transport activity of three OATP isoforms.

Saito R, Akiyoshi T, Tsujii K, Takahashi R, Kataoka H, Imaoka A, Ohtani H.

Toxicology in Vitro  2025

Research paper (scientific journal), Joint Work, Accepted

The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.

Hiroki Kataoka, Takeshi Akiyoshi, Yasuo Uchida, Ayuko Imaoka, Tetsuya Terasaki, Hisakazu Ohtani

J Pharm Sci. 113 ( 5 ) 1376 - 1384 2024

Research paper (scientific journal), Joint Work, Accepted

The effects of jabara juice on the intestinal permeation of fexofenadine.

Han H, Akiyoshi T, Morita T, Tsuchitani T, Nabeta M, Yajima K, Imaoka A, Ohtani H.

Biol Pharm Bull. 46 ( 12 ) 1745 - 1752 2023

Research paper (scientific journal), Joint Work, Accepted

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro.

Kojima M, Machida K, Cho S, Watanabe D, Seki H, Shimoji M, Imaoka A, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Akiyoshi T, Ohtani H.

Xenobiotica. 53 ( 5 ) 357 - 365 2023

Research paper (scientific journal), Joint Work, Accepted

Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.

Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.

J Pharmacol Sci. 153 ( 3 ) 153 - 160 2023

Research paper (scientific journal), Joint Work, Accepted

Irinotecan-induced gastrointestinal damage alters the expression of peptide transporter 1 and absorption of cephalexin in rats.

Imaoka A, Hattori T, Akiyoshi T, Ohtani H.

Biopharm Drug Dispos. 44 ( 5 ) 372 - 379 2023

Research paper (scientific journal), Joint Work, Lead author, Accepted

Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract--Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up-.

Tsuchitani T, Akiyoshi T, Imaoka A, Ohtani H.

Int J Clin Pharmacol Ther. 60 ( 5 ) 217 - 224 2022

Research paper (scientific journal), Joint Work, Accepted

Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants.

Araki N, Morita T, Akiyoshi T, Kataoka H, Yajima K, Katayama K, Imaoka A, Ohtani H.

Drug Metab Pharmacokinet. 46   100464 2022

Research paper (scientific journal), Joint Work, Accepted

Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants.

Han H, Akiyoshi T, Morita T, Kataoka H, Katayama K, Yajima K, Imaoka A, Ohtani H.

Drug Metab Pharmacokinet.  46 2022

Research paper (scientific journal), Joint Work, Accepted

Evaluation of hepatic CYP3A4 enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone and aprepitant.

Hibino H, Sakiyama N, Makino Y, Makihara-Ando R, Horinouchi H, Fujiwara Y, Kanda S, Goto Y, Yoshida T, Okuma Y, Shinno Y, Murakami S, Hashimoto H, Akiyoshi T, Imaoka A, Ohe Y, Yamaguchi M, Ohtani H.

Eur J Clin Pharmacol.  2022

Research paper (scientific journal), Joint Work, Accepted

Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient.

Hibino H, Makino Y, Sakiyama N, Makihara-Ando R, Hashimoto H, Akiyoshi T, Imaoka A, Fujiwara Y, Ohe Y, Yamaguchi M, Ohtani H.

Int J Clin Pharmacol Ther.  2021

Research paper (scientific journal), Joint Work, Accepted

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants.

Yamaguchi Y, Akiyoshi T, Kawamura G, Imaoka A, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H

Drug Metab Pharmacokinet.  2021

Research paper (scientific journal), Joint Work, Accepted

Estimation of absolute oral bioavailability without performing an intravenous clinical study.

Ohtani H, Iwata R, Imaoka A, Akiyoshi T.

Drug Metab Pharmacokinet.   2021

Research paper (scientific journal), Joint Work, Accepted

Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resAnalysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol.veratrol.

Akiyoshi T, Uchiyama M, Inada R, Imaoka A, Ohtani H.

Drug Metab Pharmacokinet.  2021

Research paper (scientific journal), Joint Work, Accepted

Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants

Akiyoshi T, Naitou R, Imaoka A, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H.

Int J Pharmacol Ther. 59 ( 12 ) 745 - 752 2021

Research paper (scientific journal), Joint Work, Accepted

Digoxin absorption decreased independency of P-gp activity in rats with irinotecan-induced gastrointestinal damage.

Tsuchitani T, Akiyoshi T, Imaoka A, Ohtani H.

J Pharm Health Care Sci.  2021

Research paper (scientific journal), Joint Work, Accepted