Imaoka, Ayuko

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 臨床薬物動態学講座 ( Shiba-Kyoritsu )

Position

Research Associate/Assistant Professor/Instructor
 

Papers 【 Display / hide 】

  • Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity.

    Takeshi Akiyoshi, Arun Kumar Tonduru, Hiroki Kataoka, Tokio Morita, Kodai Yajima, Ayuko Imaoka, Kazuhiro Katayama, Prasanthi Medarametla, Yasuo Uchida, Antti Poso, Hisakazu Ohtani, Tetsuya Terasaki

    Drug Metab Dispos. 53 ( 12 ) 100198 2025.12

    Joint Work, Accepted

  • Inhibition kinetics of citrus jabara juice and its components on CYP2C9 activity.

    Koinuma K, Morita T, Uekusa Y, Kikuchi H, Imaoka A, Akiyoshi T, Ohtani H.

    J Pharm Sci. 114 ( 11 ) 103983 2025.09

    Research paper (scientific journal), Joint Work, Accepted

  • Comparative analysis of the single-molecule transport kinetics of OATP1B1 genetic variants.

    Tsujii K, Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.

    J Pharmacol Sci. 158 ( 3 ) 166 - 171 2025.07

    Research paper (scientific journal), Joint Work, Accepted

  • Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components.

    Koinuma K, Noto K, Morita T, Uekusa Y, Kikuchi H, Shimoji M, Seki H, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Imaoka A, Akiyoshi T, Ohtani H.

    J Pharm Sci. 114 ( 2 ) 849 - 856 2025

    Joint Work, Accepted

  • The effect of organic solvents on the in vitro transport activity of three OATP isoforms.

    Saito R, Akiyoshi T, Tsujii K, Takahashi R, Kataoka H, Imaoka A, Ohtani H.

    Toxicology in Vitro  2025

    Research paper (scientific journal), Joint Work, Accepted

display all >>

Page Top ▲

Papers, etc., Registered in KOARA 【 Display / hide 】

display all >>

Page Top ▲

Presentations 【 Display / hide 】

  • 組換え CYP2C19 変異型酵素に対する 6’, 7’-dihydroxybergamottin の MBI キネティクスとその基質依存性

    [Domestic presentation]  日本薬学会第146年会, 

    2026.03
    , 

    Poster presentation

  • 柑橘マーマレードによる消化管 CYPs および OATPs の阻害を介した相互作用リスク評価

    [Domestic presentation]  日本薬学会第146年会, 

    2026.03
    , 

    Poster presentation

  • Food–Drug Interactions via Intestinal OATPs Inhibition by Thai Fruits: -International Collaboration Study-

    [Domestic presentation]  第35回日本医療薬学会年会, 

    2025.11
    , 

    Poster presentation

  • OATP1B1阻害剤のpre-incubation効果に対する遺伝的変異の影響

    [Domestic presentation]  第19回次世代を担う若手のための医療薬科学シンポジウム, 

    2025.09
    , 

    Poster presentation

  • フェキソフェナジンの消化管吸収に対するジクロフェナクの阻害作用〜マウス in vivo での検討〜

    [Domestic presentation]  医療薬学フォーラム2025, 

    2025.06
    , 

    Poster presentation

display all >>

Page Top ▲

Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 抗菌薬併用によるアルミニウム吸収亢進の全身曝露評価およびメカニズムの解明

    2020.04
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

  • キレート形成による薬物相互作用に関する新規機序の解明と金属吸収亢進のリスクの検討

    2018.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

Page Top ▲

Awards 【 Display / hide 】

  • 優秀発表賞

    2024.03, OATP1B1各種遺伝的変異型の単分子輸送特性の比較

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 優秀発表賞

    2023.06, 柑橘系果物に含有される CYPs 阻害成分の含量とその果実間差の網羅的解析

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 優秀発表賞

    2022.06, 5-FU 誘発性消化管障害時のマグネシウムの体内動態評価

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 優秀発表賞

    2021.06, 難溶性薬物の過飽和溶液の安定性に対するウルトラファインバブルの影響

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 優秀発表賞

    2021.06, クランベリージュースによる消化管 OATPs 阻害活性の検討とその阻害成分の探索

    Type of Award： Award from Japanese society, conference, symposium, etc.

display all >>

Page Top ▲
 

Courses Taught 【 Display / hide 】

  • PRIOR LEARNING FOR CLINICAL PRACTICE 2

    2025

  • PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

    2025

  • PHARMACEUTICAL-ENGLISH SEMINAR

    2025

  • ENGLISH EXERCISES FOR PHARMACEUTICAL SCIENCES

    2025

  • BACHELOR'S THESIS

    2025

display all >>

Page Top ▲