Ichikawa, Daiju

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 病態生理学講座 ( Shiba-Kyoritsu )

Position

Assistant Professor/Senior Assistant Professor
 

Papers 【 Display / hide 】

  • Immunomodulatory Effect of Proteasome Inhibitors via the Induction of Immunogenic Cell Death in Myeloma Cells

    Matsushita M., Kashiwazaki S., Kamiko S., Kobori M., Osada M., Kunieda H., Hirao M., Ichikawa D., Hattori Y.

    Pharmaceuticals 16 ( 10 )  2023.10

    　View Summary

    Several anti-cancer drugs are known to have immunomodulatory effects, including immunogenic cell death (ICD) of cancer cells. ICD is a form of apoptosis which is caused by the release of damage-associated molecular patterns (DAMPs), the uptake of cancer antigens by dendritic cells, and the activation of acquired immunity against cancer cells. ICD was originally reported in solid tumors, and there have been few reports on ICD in multiple myeloma (MM). Here, we showed that proteasome inhibitors, including carfilzomib, induce ICD in myeloma cells via an unfolded protein response pathway distinct from that in solid tumors. Additionally, we demonstrated the potential impact of ICD on the survival of patients with myeloma. ICD induced by proteasome inhibitors is expected to improve the prognosis of MM patients not only by its cytotoxic effects, but also by building strong immune memory response against MM cells in combination with other therapies, such as chimeric antigen receptor—T cell therapy.

  • GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c-MET tyrosine kinase

    Mikio Okayama, Kota Fujimori, Mariko Sato, Koichi Samata, Koki Kurita, Hiromu Sugiyama, Yutaka Suto, Genji Iwasaki, Taketo Yamada, Fumiyuki Kiuchi, Daiju Ichikawa, Maiko Matsushita, Maki Hirao, Hisako Kunieda, Kohei Yamazaki, Yutaka Hattori

    Cancer Med .  12 ( 8 ) 9749 - 9759 2023.04

    Research paper (scientific journal), Joint Work, Accepted

  • A thermoresponsive cationic block copolymer brush-grafted silica bead interface for temperature-modulated separation of adipose-derived stem cells

    Nagase K., Okada A., Matsuda J., Ichikawa D., Hattori Y., Kanazawa H.

    Colloids and Surfaces B: Biointerfaces (Colloids and Surfaces B: Biointerfaces)  220 2022.12

    ISSN  09277765

    　View Summary

    Adipose-derived mesenchymal stem cells (ADSCs) have beneficial effects in cell transplantation therapy; these cells are collected from adipose tissue using low-invasive methods. However, to prepare ADSCs for cell therapy, a cell separation method that neither involves modification of the cell surface nor causes loss of cell activity is needed. Here, we aimed to develop ADSC separation columns using thermoresponsive cationic block copolymer brush-grafted beads as packing materials. The block copolymer brush was formed by a bottom cationic segment, poly(N,N-dimethylaminopropylacrylamide) (PDMAPAAm), and an upper thermoresponsive segment, poly(N-isopropylacrylamide) (PNIPAAm), and was grafted in two atom transfer radical polymerization reactions. The copolymer brush-grafted silica beads were packed into a column. An ADSC suspension was introduced into the columns at 37 °C and adsorbed on the copolymer brush-modified beads through electrostatic and hydrophobic interactions with the PDMAPAAm and PNIPAAm segments, respectively. The adsorbed ADSCs eluted from the column by lowering the temperature to 4 °C. In contrast, most Jurkat and vascular endothelial cells eluted at 37 °C, because of the relatively weaker electrostatic interactions with the block copolymer brush compared to ADSCs. Using the prepared column, a mixture of ADSCs and Jurkat cells was separated by changing the column temperature. The recovered ADSCs exhibited cell activity. The developed cell separation column may be useful for isolating ADSCs without cell surface modification, while maintaining cell activity.

  • Integrin β5 and β7 expression in lenalidomide-resistant multiple myeloma cells.

    Hattori Y, Futo T, Uozaki R, Ichikawa D, Yamaguchi T, Yamamoto T, Matsushita M, Hirao M.

    Int J Hematol.  115 ( 4 ) 605 - 608 2022.04

    Accepted

  • PAX5-positive plasma cell leukemia presenting as lymphocytosis

    Suzuka Tateno, Maki Hirao, Takahide Kikuchi, Yuiko Tsukada, Hisako Kunieda, Makoto Osada, Kohei Yamazaki, Ryunosuke Denda, Shigemichi Hirose, Maiko Matsushita, Daiju Ichikawa, Yutaka Hattori

    Rinsho Ketsueki 63 ( 10 ) 1415 - 1420 2022

    Research paper (scientific journal)

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Integrin β5 and β7 expression in lenalidomide-resistant multiple myeloma cells

    Hattori Y., Futo T., Uozaki R., Ichikawa D., Yamaguchi T., Yamamoto T., Matsushita M., Hirao M.

    International Journal of Hematology (International Journal of Hematology)  115 ( 4 ) 605 - 608 2022.04

    ISSN  09255710

  • E3 ubiquitin ligase in T cell anergy

    ICHIKAWA Daiju

    臨床免疫・アレルギー科 (科学評論社)  62 ( 4 ) 411 - 417 2014.10

    Article, review, commentary, editorial, etc. (scientific journal),  ISSN  1881-1930

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Presentations 【 Display / hide 】

  • Identification of antitumor drugs inducing endogenous dsRNA and elucidation of their mechanism.

    市川大樹, 上岡優菜, 松下麻衣子, 大江知之

    [Domestic presentation]  日本薬学会第146年会 (大阪), 

    2026.03
    , 

    Poster presentation

  • 内在性ニコチン受容体機能修飾因子Ly6Hの相互作用分子の網羅的解析

    清水 理帆, 市川 大樹, 井上 直和, 辻 祥太郎, 森脇 康博

    [Domestic presentation]  日本薬学会第146年会, 

    2026.03
    , 

    Poster presentation

  • 慢性骨髄性白血病における新たな無治療寛解維持予測因子としてのミトコンドリアDNAコピー数の検討

    鈴木未央, 飯島和香奈, 市川大樹, 山崎理絵, 櫻井政寿, 片山圭亮, 岡本真一郎, 服部豊, 松下麻衣子

    [Domestic presentation]  第86回日本血液学会学術集会 (京都) , 

    2024.10
    , 

    Poster presentation

  • 免疫原性細胞死を強力に誘導する天然由来化合物の同定

    松下麻衣子,栗田昂希,藤浪太晴,須藤豊,市川大樹,服部豊

    [Domestic presentation]  第21回日本免疫治療学会学術集会, 

    2024.05
    , 

    Poster presentation

  • Epigenetic factor CDYL2 attenuates lenalidomide snsitivity in multiple myeloma

    Daiju Ichikawa, Yuna Kamioka, Maiko Mastushita, Yutaka Hattori

    [Domestic presentation]  第48回日本骨髄腫学会学術集会 (東京, 日本) , 

    2023.05
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • エピゲノム制御による薬剤抵抗性難治性造血器腫瘍の克服

    2022.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

  • Overcoming resistance to new drug in hematological malignancy tageting LncRNA.

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Identification of novel therapeutic target molecules and the molecular mechanism for refractory multiple myeloma

    2016.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Principal investigator

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Awards 【 Display / hide 】

  • 優秀ポスター演題賞

    市川大樹, 2023.05, 第48回日本骨髄腫学会学術集会, Epigenetic factor CDYL2 attenuates lenalidomide sensitivity in multiple myeloma

    Type of Award： International academic award (Japan or overseas)

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Courses Taught 【 Display / hide 】

  • PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

    2025

  • PHARMACY SEMINAR

    2025

  • PHARMACEUTICAL-ENGLISH SEMINAR

    2025

  • INTRODUCTION OF PSYCHOLOGY

    2025

  • HUMAN BEINGS AND MEDICATION

    2025

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