Arita, Makoto

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 代謝生理化学講座 (Shiba-Kyoritsu)

Position

Professor

E-mail Address

E-mail address

Related Websites

Profile Summary 【 Display / hide

  • Lipids are recognized as extremely diverse molecules. Precise determination of molecular lipid species becomes a prerequisite not only to understand their biological functions in physiology and disease, but also to discover novel bioactive lipids that may link between lipid metabolisms and biological phenotypes. A powerful method for the analysis of lipids is liquid chromatography tandem mass spectrometry (LC-MS/MS). Our research is aimed at elucidating structure and function of endogenous lipid mediators that regulate inflammation and tissue homeostasis. Polyunsaturated fatty acid (PUFA)-derived mediators are formed by enzymatic oxidation through the action of cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 monooxygenases (CYP). By using LC-MS/MS-based lipidomics, we provided new insights into the cellular and molecular mechanisms of inflammatory resolution, especially the functional roles of 12/15-LOX-expressing eosinophils and macrophages in controlling the resolution of inflammation. Also our research is focused on understanding omega-3 PUFA’s function using genetic and lipidomic approaches, and has identified novel metabolic pathway and bioactive metabolites that may link to omega-3 PUFA’s anti-inflammatory actions. These endogenous mediators with potent anti-inflammatory property could lead to the development of novel therapeutics for disease when sustained inflammation is suspected as key components of pathogenesis. Also we put a lot of efforts into development and application of target and non-target multi-lipidomics platform to discover novel link between lipid metabolism and biological phenotypes.

Career 【 Display / hide

  • 1997.04
    -
    2000.06

    The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor

  • 2000.07
    -
    2003.06

    Brigham&Women's Hospital / Harvard Medical School, Postdoctoral Fellow

  • 2003.07
    -
    2006.09

    Brigham&Women's Hospital / Harvard Medical School, Instructor

  • 2006.10
    -
    2007.03

    JST, PRESTO, Researcher

  • 2007.04
    -
    2014.03

    The University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate Professor

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Academic Background 【 Display / hide

  • 1988.04
    -
    1992.03

    The University of Tokyo, Faculty of Pharmaceutical Sciences

    University, Graduated

  • 1992.04
    -
    1994.03

    The University of Tokyo, Graduate School of Pharmaceutical Sciences

    Graduate School, Completed, Master's course

  • 1994.04
    -
    1997.03

    The University of Tokyo, Graduate School of Pharmaceutical Sciences

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(薬学), The University of Tokyo, Coursework, 1997.03

    ビタミンE輸送タンパク質の生理機能の解明

 

Research Areas 【 Display / hide

  • Molecular biology

  • Functional biochemistry

  • Biological pharmacy

  • General medical chemistry

Research Keywords 【 Display / hide

  • Metabolomics

  • Lipoquality

  • Regulation of Inflammation

  • Bioactive molecules

  • Lipid Biochemistry

Research Themes 【 Display / hide

  • Quality of lipids in biological systems, 

    2015.07
    -
    Present

  • Development and application of target and non-target multi-lipidomics platform, 

    2014.04
    -
    Present

  • Mediator lipidomics in acute inflammation and resolution, 

    2006.10
    -
    Present

  • Genetic and lipidomic approach to understand anti-inflammatory property of omega-3 PUFAs, 

    2000.07
    -
    Present

 

Books 【 Display / hide

  • 実験医学別冊:メタボロミクス実践ガイド

    有田誠, 羊土社, 2021

    Scope: 生命の脂質多様性から解き明かす病態・バイオロジー研究,  Contact page: 283-285

  • ヒトマイクロバイオーム研究最前線Vol.2

    岡橋伸幸、上田政宏、有田誠, NTS, 2020

    Scope: マイクロバイオームのリピドミクス,  Contact page: 71-78

  • 医学のあゆみ増刊:脂質クオリティ研究の基礎と臨床(有田誠/編)

    医歯薬出版, 2019

  • 実験医学別冊:脂質解析ハンドブック

    有田誠, 羊土社, 2019

    Scope: 第1部 生体における脂質の構造と機能 4.脂肪酸,  Contact page: 49-54

  • 実験医学増刊:脂質クオリティ -生命機能と健康を支える脂質の多様性-(有田誠/編)

    羊土社, 2018

    Scope: 編集、序、概論、第1章-1

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Papers 【 Display / hide

  • Global profiling of gut microbiota-associated lipid metabolites in antibiotic-treated mice by LC-MS/MS-based analyses.

    Okahashi N, Ueda M, Yasuda S, Tsugawa H, *Arita M.

    STAR Protocols 2   100492 2021.06

    Research paper (scientific journal), Joint Work, Accepted

  • ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss.

    Osada H, Toda E, Homma K, Guzman NA, Nagai N, Ogawa M, Negishi K, Arita M, Tsubota K, *Ozawa Y.

    Cell Death and Disease 12 ( 5 ) 458 2021.05

    Research paper (scientific journal), Joint Work, Accepted

  • Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation.

    Ito Y, Sasaki T, Li Y, Tanoue T, Sugiura Y, Skelly AN, Suda W, Kawashima Y, Okahashi N, Watanabe E, Horikawa H, Shiohama A, Kurokawa R, Kawakami E, Iseki H, Kawasaki H, Iwakura Y, Shiota A, Yu L, Hisatsune J, Koseki H, Sugai M, Arita M, Ohara O, Matsui T, Suematsu M, Hattori M, Atarashi K, Amagai M, *Honda K.

    Cell Reports 35 ( 4 ) 109052 2021.04

    Research paper (scientific journal), Joint Work, Accepted

  • ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.

    Saika A, Nagatake T, Hirata S, Sawane K, Adachi J, Abe Y, Isoyama J, Morimoto S, Node E, Tiwari P, Hosomi K, Matsunaga A, Honda T, Tomonaga T, Arita M, Kabashima K, *Kunisawa J.

    FASEB Journal 35 ( 4 ) e21354 2021.04

    Research paper (scientific journal), Joint Work, Accepted

  • Analysis of lipid A in gram-negative intestinal bacteria using liquid chromatography-quadrupole time-of-flight mass spectrometry.

    *Okahashi N, Ueda M, Matsuda F, *Arita M.

    Metabolites 11   197 2021.03

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergy diseases.

    *Miyata J, Fukunaga K, Kawashima Y, Ohara O, Kawana A, Asano K, Arita M.

    Prostaglandins Other Lipid Mediat  150   106477 2020.07

    Introduction and explanation (scientific journal), Joint Work

  • Cysteinyl leukotriene metabolism of human eosinophils in allergic disease.

    Miyata J, *Fukunaga K, Kawashima Y, Ohara O, Arita M.

    Allergol Int 69   28 - 34 2020.01

    Introduction and explanation (scientific journal), Joint Work

  • Current state and future prospect of therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma.

    Yamamoto T, *Miyata J, Arita M, Fukunaga K, Kawana A.

    Respir Invest  57 ( 6 ) 534 - 543 2019.11

    Introduction and explanation (scientific journal), Joint Work

  • Lipidomics needs more standardization

    Liebisch G., Ahrends R., Arita M., Arita M., Bowden J., Ejsing C., Griffiths W., Holčapek M., Köfeler H., Mitchell T., Wenk M., Ekroos K.

    Nature Metabolism (Nature Metabolism)  1 ( 8 ) 745 - 747 2019.08

    Introduction and explanation (scientific journal), Joint Work

  • Omega-3 fatty acid–derived mediators that control inflammation and tissue homeostasis.

    Ishihara T, Yoshida M, *Arita M.

    Int Immunol  31 ( 9 ) 559 - 567 2019.08

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide

  • Biology of LipoQuality: Advanced lipidomics technology and its application in biology

    Makoto Arita

    9th International Singapore Lipid Symposium (iSLS9), 2021.03, Symposium, Workshop, Panelist (nomination)

  • Biology of LipoQuality: Advanced lipidomics technology and its application in biology

    Makoto Arita

    MBSJ2020 (オンライン) , 2020.12, Symposium, Workshop, Panelist (nomination)

  • 最先端リピドミクスから解き明かす病態・バイオロジー研究

    有田誠

    第45回日本医用マススペクトル学会年会 (オンライン) , 2020.09, Symposium, Workshop, Panelist (nomination)

  • 脂質代謝ネットワークによる炎症性疾患の制御

    有田誠

    第93回日本生化学会大会, 2020.09, Symposium, Workshop, Panelist (nomination)

  • Biology of LipoQuality: Omega-3 fatty acid cascade that controls inflammation and tissue homeostasis

    有田誠

    第93回日本薬理学会年会, 2020.03, Oral Presentation(guest/special)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 脂肪酸代謝ネットワークによる生体制御およびその制御破綻による疾患メカニズムの解明

    2020.04
    -
    2024.03

    日本学術振興会, 科学研究費助成事業(科学研究費補助金), 有田誠, 基盤研究(A), Research grant, Principal Investigator

  • ヒト子宮内膜を用いた着床障害のリピドミクス解析

    2020.04
    -
    2022.03

    国立研究開発法人日本医療研究開発機構(AMED), 革新的先端研究開発支援事業ステップタイプ(FORCE), 廣田泰, Commissioned research, Co-investigator

  • 腸内細菌株カクテルを用いた新規医薬品の創出

    2016.10
    -
    2021.03

    Japan Agency for Medical Research and Development, Leading Advanced Projects for medical innovation, 本田賢也, Commissioned research, Co-investigator

  • 「リポクオリティ」領域研究の国際連携

    2015.11
    -
    2021.03

    Japan Society for the Promotion of Science, 科学研究費助成事業(学術研究助成基金助成金), 有田誠, 国際共同研究加速基金(国際活動支援班), Research grant, Principal Investigator

  • Advanced lipidomics to illuminate the physiological importance of LipoQuality

    2015.06
    -
    2020.03

    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research, Makoto Arita, Grant-in-Aid for Scientific Research on Innovative Areas, Research grant, Principal Investigator

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Awards 【 Display / hide

  • Commendation for Science and Technology by the Minister of MEXT

    有田誠, 2021.04, 文部科学省, 生命の脂質多様性の解明と生物学的意義に関する研究

    Type of Award: International Academic Awards

  • 日本脂質栄養学会ランズ賞学術賞

    有田誠, 2016.09, 日本脂質栄養学会, ω3脂肪酸の代謝と抗炎症作用に関する研究

    Type of Award: Awards of National Conference, Council and Symposium

  • Young Scientists' Prize of Ministry of Education, Culture, Sports, Science and Technology, Japan

    2009.04, 文部科学省, オメガ3脂肪酸由来の抗炎症性脂質メディエーターの研究

    Type of Award: International Academic Awards

  • Young Investigator Award: 9th International Conference of Eicosanoids other Bioactive Lipids in Cancer, Inflammation & Related Diseases (San Francisco)

    2005

    Type of Award: Awards of International Conference, Council and Symposium

 

Courses Taught 【 Display / hide

  • VISUALIZING PATHOPHYSIOLOGY UNDER THE SEVERE STRESS IN ACUTE CARE

    2021

  • STUDY OF MAJOR FIELD: (PHYSIOLOGICAL CHEMISTRY AND METABOLISM)

    2021

  • SPECIAL LECTURES BY GUEST SPEAKERS

    2021

  • SPECIAL LECTURES BY GUEST SPEAKERS

    2021

  • SPECIAL LECTURES BY GUEST SPEAKERS

    2021

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Courses Previously Taught 【 Display / hide

  • 代謝生化学

    Keio University, 2017, Spring Semester, General education subject, Lecture

  • 実験法概論

    Keio University, 2017, Autumn Semester, Lecture

  • 薬学基礎実習

    Keio University, 2017, Autumn Semester, Laboratory work/practical work/exercise

  • 細胞の機能と構成分子

    Keio University, 2017, Autumn Semester, General education subject, Lecture

  • 生化学2

    Keio University, 2017, Autumn Semester, General education subject, Lecture

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