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Affiliation
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Faculty of Pharmacy, Department of Pharmacy 代謝生理化学講座 (Shiba-Kyoritsu)
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Position
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Professor
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Related Websites
Arita, Makoto
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Profile Summary 【 Display / hide 】
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Our research is aimed at elucidating structure and function of endogenous lipid mediators that regulate inflammation and tissue homeostasis. Polyunsaturated fatty acid (PUFA)-derived mediators are formed by enzymatic oxidation through the action of cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 monooxygenases (CYP). By using LC-MS/MS-based lipidomics, we provided new insights into the cellular and molecular mechanisms of inflammatory resolution.
Also, we have established a non-targeted lipidomics platform that enables us to identify the structural diversity of lipids in human and mouse tissues, cells, and commensal bacteria. The Lipidome Atlas project is ongoing by developing MS imaging techniques to visualize the effect of the local environment created by specific lipids on the dynamics and functions of multicellular systems. We aim to elucidate the mechanisms that create, regulate, and recognize lipid diversity and its localization in vivo, as well as to elucidate diseases caused by the disruption of such mechanisms.
Other Affiliation 【 Display / hide 】
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Human Biology Microbiome Quantum Research Center (Bio2Q), Core Director
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Dean, Faculty of Pharmacy
Career 【 Display / hide 】
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1997.04-2000.06
The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor
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2000.07-2003.06
Brigham&Women's Hospital / Harvard Medical School, Postdoctoral Fellow
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2003.07-2006.09
Brigham&Women's Hospital / Harvard Medical School, Instructor
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2006.10-2007.03
JST, PRESTO, Researcher
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2007.04-2014.03
The University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate Professor
Academic Background 【 Display / hide 】
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1988.04-1992.03
The University of Tokyo, Faculty of Pharmaceutical Sciences
University, Graduated
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1992.04-1994.03
The University of Tokyo, Graduate School of Pharmaceutical Sciences
Graduate School, Completed, Master's course
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1994.04-1997.03
The University of Tokyo, Graduate School of Pharmaceutical Sciences
Graduate School, Completed, Doctoral course
Academic Degrees 【 Display / hide 】
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博士（薬学）, The University of Tokyo, Coursework, 1997.03
ビタミンE輸送タンパク質の生理機能の解明
Research Areas 【 Display / hide 】
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Life Science / Molecular biology
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Life Science / Functional biochemistry
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Life Science / Pharmaceutical hygiene and biochemistry
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Life Science / Medical biochemistry
Research Keywords 【 Display / hide 】
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Lipidome Atlas
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Lipoquality
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Regulation of Inflammation
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Bioactive molecules
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Lipid Biochemistry
Research Themes 【 Display / hide 】
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リピドームアトラスの創出,
2021.10-Present -
Quality of lipids in biological systems,
2015.07-Present -
Development and application of target and non-target multi-lipidomics platform,
2014.04-Present -
Mediator lipidomics in acute inflammation and resolution,
2006.10-Present -
Genetic and lipidomic approach to understand anti-inflammatory property of omega-3 PUFAs,
2000.07-Present
Books 【 Display / hide 】
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Mass Spectrometry for Lipidomics (Holcapek M., Ekroos K. eds.)
Ueda M, Okahashi N, *Arita M., Willey-VCH, 2023, Page： 752
Scope: Chapter 27: Microbial Lipidomics, Contact page： 689-704 , Accepted
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実験医学別冊：メタボロミクス実践ガイド
有田誠, 羊土社, 2021
Scope: 生命の脂質多様性から解き明かす病態・バイオロジー研究, Contact page： 283-285
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ヒトマイクロバイオーム研究最前線Vol.2
岡橋伸幸、上田政宏、有田誠, NTS, 2020
Scope: マイクロバイオームのリピドミクス, Contact page： 71-78
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医学のあゆみ増刊：脂質クオリティ研究の基礎と臨床（有田誠/編）
医歯薬出版, 2019
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実験医学別冊：脂質解析ハンドブック
有田誠, 羊土社, 2019
Scope: 第１部 生体における脂質の構造と機能 4.脂肪酸, Contact page： 49-54
Papers 【 Display / hide 】
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Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast.
Hoshikawa Y, Shirota N, Tsugawa H, Kimura S, Matsuyama A, Yashiroda Y, Arita M, Fenical W, Yoshida M, *Nishimura S.
Proc Natl Acad Sci USA 122 ( 22 ) e2422126122 2025.05
Research paper (scientific journal), Joint Work, Accepted
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Technical recommendations for analyzing oxylipins by liquid chromatography-mass spectrometry.
*Schebb NH, Kampschulte N, Hagn G, Plitzko K, Meckelmann SW, Ghosh S, Joshi R, Kuligowski J, Vuckovic D, Botana MT, Sánchez-Illana Á, Zandkarimi F, Das A, Yang J, Schmidt L, Checa A, Roche HM, Armando AM, Edin ML, Lih FB, Aristizabal-Henao JJ, Miyamoto S, Giuffrida F, Moussaieff A, Domingues R, Rothe M, Hinz C, Das US, Rund KM, Taha AY, Hofstetter RK, Werner M, Werz O, Kahnt AS, Bertrand-Michel J, Le Faouder P, Gurke R, Thomas D, Torta F, Milic I, Dias IHK, Spickett CM, Biagini D, Lomonaco T, Idborg H, Liu JY, Fedorova M, Ford DA, Barden A, Mori TA, Kennedy PD, Maxey K, Ivanisevic J, Gallart-Ayala H, Gladine C, Wenk M, Galano JM, Durand T, Stark KD, Barbas C, Garscha U, Gelhaus SL, Ceglarek U, Flamand N, Griffin JL, Ahrends R, Arita M, Zeldin DC, Schopfer FJ, Quehenberger O, Julian R, Nicolaou A, Blair IA, Murphy MP, Hammock BD, Freeman B, Liebisch G, Serhan CN, Köfeler HC, Jakobsson PJ, Steinhilber D, Gelb MH, Holčapek M, Andrew R, Giera M, FitzGerald GA, Murphy RC, Newman JW, Dennis EA, Ekroos K, Milne GL, Gijón MA, Vesper HW, Wheelock CE, O'Donnell VB.
Science Signaling 18 ( 887 ) eadw1245 2025.05
Research paper (scientific journal), Joint Work, Accepted
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Transcriptomic and lipidomic analysis of aging-associated inflammatory signature in mouse liver.
*Ishihara T, Tsugawa H, Iwanami S, Chang JC, Minoda A, *Arita M.
Inflammation and Regeneration 45 ( 1 ) 13 2025.05
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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Ito E, Hayashizaki R, Hosaka T, Yamane T, Miyata J, *Isobe Y, *Arita M.
Frontiers in Immunology 16 1565670 2025.04
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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Kurizaki Y, Matsuzawa Y, Takahashi M, Takeda H, Hasegawa M, Arita M, Miyamoto J, *Tsugawa H.
Analytical Chemistry 97 ( 14 ) 7861 - 7868 2025.04
Research paper (scientific journal), Joint Work, Accepted
Papers, etc., Registered in KOARA 【 Display / hide 】
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Arita, Makoto
科学研究費補助金研究成果報告書 2017
Reviews, Commentaries, etc. 【 Display / hide 】
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Exploring protein lipidation by mass spectrometry-based proteomics.
Tsumagari K, *Isobe Y, *Imami K, *Arita M.
Journal of biochemistry 175 ( 3 ) 225 - 233 2024.03
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author
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両角諭、岡橋伸幸、有田誠
生化学（日本生化学会） 95 ( 4 ) 428 - 435 2023.08
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author
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有田誠
ファルマシア (日本薬学会) 59 ( 1 ) 9 - 13 2023.01
Article, review, commentary, editorial, etc. (scientific journal), Single Work, Lead author, Corresponding author
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Functional significance of ion channels during macropinosome resolution in immune cells
*Maekawa M, Natsume, *Arita M
Front Physiol 13 1037758 2022.10
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author
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Polyunsaturated fatty acid-derived lipid mediators that regulate epithelial homeostasis.
Naganuma T, Funinami N, *Arita M.
Biol Pharm Bull 45 998 - 1007 2022.08
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author
Presentations 【 Display / hide 】
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Eosinophil diversity and lipid mediators in controlling inflammation and allergy
Makoto Arita
The 129th Annual Meeting of the Japanese Ophthalmological Society,
2025.04,Symposium, workshop panel (nominated)
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脂質多様性の生物学とリピドームアトラス
有田誠
第25回京都糖尿病動脈硬化研究会,
2025.04,Oral presentation (invited, special)
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Cutting-edge lipidomics to elucidate the host-microbiome interactions
Makoto Arita
KoMetS2025,
2025.04,Oral presentation (keynote)
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Advanced lipidomics to illuminate the functional postbiotics in host-microbiome interactions
Makoto Arita
Postbiotics Conference 2025,
2025.03,Symposium, workshop panel (nominated)
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Lipidome signatures associated with aging and host-microbiome interactions
Makoto Arita
The 3rd Keio University WPI-Bio2Q International Symposium,
2025.03,Symposium, workshop panel (nominated)
Research Projects of Competitive Funds, etc. 【 Display / hide 】
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Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q)
2022.10-2032.03World Premier International Research Center Initiative (WPI), Research grant, Coinvestigator(s)
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健康寿命伸長にむけた腸内細菌動作原理の理解とその応用
2022.10-2025.12Japan Agency for Medical Research and Development (AMED), ムーンショット型研究開発事業, Commissioned ｒesearch, Coinvestigator(s)
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遺伝的多様性と機能に関するマルチオミックスを中心としたヒト免疫評価法の確立と支援の為のサポート機関
2022.10-2025.03Japan Agency for Medical Research and Development (AMED), ワクチン開発のための世界トップレベル研究開発拠点の形成事業, Commissioned ｒesearch, Coinvestigator(s)
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2021.10-2027.03
Japan Science and Technology Agency (JST), The Exploratory Research for Advanced Technology (ERATO), Makoto Arita, Joint research, Principal investigator
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リバーストランスレーショナル創薬に向けた包括的マイクロバイオーム制御基盤技術開発
2021.10-2027.03Japan Agency for Medical Research and Development (AMED), 次世代治療・診断実現のための創薬基盤技術開発事業（腸内マイクロバイオーム制御による次世代創薬技術の開発）（複合型）, Commissioned ｒesearch, Coinvestigator(s)
Awards 【 Display / hide 】
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Commendation for Science and Technology by the Minister of MEXT
有田誠, 2021.04, 文部科学省, 生命の脂質多様性の解明と生物学的意義に関する研究
Type of Award： International academic award (Japan or overseas)
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日本脂質栄養学会ランズ賞学術賞
有田誠, 2016.09, 日本脂質栄養学会, ω３脂肪酸の代謝と抗炎症作用に関する研究
Type of Award： Award from Japanese society, conference, symposium, etc.
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Young Scientists' Prize of Ministry of Education, Culture, Sports, Science and Technology, Japan
2009.04, 文部科学省, オメガ３脂肪酸由来の抗炎症性脂質メディエーターの研究
Type of Award： International academic award (Japan or overseas)
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Young Investigator Award: 9th International Conference of Eicosanoids other Bioactive Lipids in Cancer, Inflammation & Related Diseases (San Francisco)
2005
Type of Award： Award from international society, conference, symposium, etc.
Courses Taught 【 Display / hide 】
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ADVANCED BODY SYSTEMS AND REGULATION
2025
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STUDY OF MAJOR FIELD: (PHYSIOLOGICAL CHEMISTRY AND METABOLISM)
2025
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SEMINAR: (PHYSIOLOGICAL CHEMISTRY AND METABOLISM)
2025
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RESEARCH FOR BACHELOR'S THESIS 1
2025
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PHARMACEUTICAL-ENGLISH SEMINAR
2025
Courses Previously Taught 【 Display / hide 】
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代謝生化学
Keio University
2017.04-2018.03,Spring Semester, Lecture
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実験法概論
Keio University
2017.04-2018.03,Autumn Semester, Lecture
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薬学基礎実習
Keio University
2017.04-2018.03,Autumn Semester, Laboratory work/practical work/exercise
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細胞の機能と構成分子
Keio University
2017.04-2018.03,Autumn Semester, Lecture
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生化学２
Keio University
2017.04-2018.03,Autumn Semester, Lecture
Memberships in Academic Societies 【 Display / hide 】
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日本抗加齢医学会,
2021.04-Present -
日本脂質栄養学会,
2014.04-Present -
日本分子生物学会,
2012.04-Present -
日本免疫学会,
2012.04-Present -
日本医用マススペクトル学会,
2008.04-Present