KEIO RESEARCHERS INFORMATION SYSTEM

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1997.03

  Hokkaido University, Faculty of Science

  University, Graduated

• 2002.03

  Kyoto University, Graduate School, Division of Natural Science

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• PhD, Kyoto University, Coursework, 2002.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Developmental biology (Developmental Biology)

• Life Science / Morphology and anatomical structure

• Life Science / Biophysics

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• bioimaging

• tunicate

• mechanobiology

• evodev

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• 尾芽胚の曲がりを支える３Ｄ形態ロジック, 

  2016.04

  -

  2018.03

• Logic of the Elongation of Tailbud in Chordates, 

  2013

  -

  2014

• quantitative analysis of morphogenesis by whole-animal 4D imaging, 

  2009

  -

  2011

  　View Summary

  Tailbud feature binds various chordates into one common group because all chordates have tails at larval stage. In this study, to understand a comprehensive anatomy of tailbud embryo at single-cell-level, we reconstructed three-dimensional computer model from confocal image stacks of Ciona tailbud embryo (stage 22, 10.9 hpf at 18 °C) by using Tassy’s method (2006). As a result, we characterized unique cell arrangement in each tissue and revealed that the tailbud embryo consists of 1583 cells.

• Quantitative Analysis of Brain Vesicle Formation by 4D imaging, 

  2012

  -

  2013

  　View Summary

  Purpose of the Research Project
  
  Different region of central nervous system, fore brain, mid brain, hind brain and spinal cord originates from one neural tube at organogenesis period. Defects of neural tube formation cause severe diseases, including anencephaly and spina bifida. While understanding of differentiation at the molecular level has been deepened, the molecular mechanism of the morphogenesis of neural tubes at different regions remains to be clarified.
  
  One of chordate, ascidian a

• Robustness and Polymorphism of Individual Morphology in the Phylotypic Stage, 

  2012

  -

  2014

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Residual Tail Twisting in Ascidian Larvae Is Stabilized by Asymmetric Myofibrils Against Bilateral Symmetry Restoration

  Kogure Yuki, Nishio Misaki, Okuda Satoru, Hotta Kohji

  FEBS Letters 25 ( 1064R.2 )  2026.04

  Research paper (scientific journal), Joint Work, Corresponding author, Accepted

• Genomic and Transcriptomic Resources for the Tropical Ascidian Phallusia philippinensis

  Shunsuke O Miyasaka, Takumi T Shito, Noburu Sensui, Euichi Hirose, Kotaro Oka, Kohji Hotta

  G3: Genes, Genomes, Genetics  2026.03

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• Optogenetic activation of primary sensory neurons induces metamorphosis in Ciona

  Nozomu M Totsuka and Kohji Hotta

  Developmental Biology 530   77 - 88 2026.02

  Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

  • Access to Document (DOI)

• Axial rotation comprises concurrent twisting and bending as distinct morphogenetic components in Ciona

  Yuki S. Kogure, Satoru Okuda, Kotaro Oka, Kohji Hotta

  Developmental Biology 530   234 - 247 2025.12

  Research paper (scientific journal), Joint Work, Corresponding author, Accepted

  • Access to Document (DOI)

• Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

  Akiko Hozumi, Nozomu M Totsuka, Arata Onodera, Yanbin Wang, Mayuko Hamada, Akira Shiraishi, Honoo Satake, Takeo Horie, Kohji Hotta, Yasunori Sasakura

  eLife  2025.06

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• The role of the second-messenger in the beginning of Ciona metamorphosis

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2023

• The role of the second-messenger in the beginning of Ciona metamorphosis

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2022

• Role of second messenger in the initiation of ascidian metamorphosis

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• Developmental mechanism of central pattern generator regulating rhythmic locomotion

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2019

• 4D developmental mechanism for different morphology in each brain region

  Hotta, Kōji

  科学研究費補助金研究成果報告書 2019

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 超透明生物！？ーガラスと同等の透明度を持つホヤ卵への進化と生存戦略

  紫藤拓巳、長谷川尚弘、岡浩太郎、堀田耕司

  academist Journal  2020.12

• Corrigendum to “Optical dissection of synaptic plasticity for early adaptation in Caenorhabditis elegans” [Neuroscience 428C (2020) 112–121] (Neuroscience (2020) 428 (112–121), (S0306452219308814), (10.1016/j.neuroscience.2019.12.026))

  Ashida K., Shidara H., Hotta K., Oka K.

  Neuroscience (Neuroscience)  434   212 - 213 2020.05

  ISSN  03064522

  　View Summary

  The author regret that, Fig. 5 in the above article was incorrect. The correct figure is published below. [Figure presented]

  • Access to Document (DOI)

• 細胞から個体へつなぐ組織としてのルール

  堀田耕司

  生命の教養学15組織としての生命　荒金 直人 編    3 - 22 2019

• ラマン分光イメージングによる非標識条件下でのホヤ胚の細胞分化識別

  HOTTA KOHJI

  比較内分泌学 (比較内分泌学)  42 ( 158 ) 52 - 53 2016.01

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

• Dual FRETイメージング法による細胞内シグナルの同時可視化生物物理トピック

  新野祐介、堀田耕司、岡浩太郎

  生物物理 50 ( 1 ) 028 - 029 2010

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• ナツメボヤ科ホヤノックアウト実験系のための基盤構築

  高田晨生，堀田耕司

  [Domestic presentation]  日本動物学会関東支部第78回大会, 

  2026.03

  , 

  Poster presentation

• ⽣物分類ゲームVRinkaiの⽔族館への応⽤可能性について

  紫藤拓巳，戸塚望，上田理名，猿渡敏郎，堀田耕司

  [Domestic presentation]  東京大学大気海洋研究所共同利用研究集会 第11回水族館シンポジウム, 

  2025.12

  , 

  Poster presentation

• 尾芽胚期におけるRTTN遺伝子の役割

  小川玲奈，嘉代冴絵，堀田耕司

  [Domestic presentation]  第7回 ホヤ研究会, 

  2025.11

  , 

  Oral presentation (general)

• ヨーロッパザラボヤのゲノム解読と尾索動物の包括的ゲノムDB 構築の試み

  紫藤拓巳，Jayakumar Vasanthan，西辻光希，西辻淑恵，河合思聞，宮坂 駿佑，岡浩太郎，榊原康文，堀田耕司

  [Domestic presentation]  第7回ホヤ研究会 , 

  2025.11

  , 

  Poster presentation

• ヨーロッパザラボヤのゲノム解読および近縁な被嚢類の遺伝子モデル作成に よる比較解析基盤の構築

  紫藤 拓巳，Jayakumar Vasanthan，西辻 光希， 西辻 淑恵， 河合 思聞，宮坂 駿佑，岡 浩太郎，榊原 康文，堀田 耕司

  [Domestic presentation]  日本動物学会第96回名古屋大会, 

  2025.09

  , 

  Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Understanding the Self-Organization and Forces that Drive Body Axis Rotation During Organogenesis

  2025.04

  -

  2027.03

  学術変革領域研究(A), Principal investigator

• 脊索動物器官形成期における左右相称性補正機構の解明

  2024.04

  -

  2028.03

  Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research, Kohji Hotta, No Setting, Principal investigator

• Elucidating the Mechanism of Bilateral Symmetry Correction During Chordate Organogenesis

  2024.04

  -

  2028.03

  基盤研究(B), Principal investigator

• Elucidation of Self-transformation and Forces that Control Axial Rotation of Tailbud Embryo

  2023.04

  -

  2025.03

  Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research, Kohji Hotta, 学術変革領域研究(A), No Setting, Principal investigator

• Quantitative analysis of the mechanism of ascidian metamorphosis

  2021.04

  -

  2023.03

  Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, No Setting, Principal investigator

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 武田科学財団　一般研究奨励

  HOTTA KOHJI, 2008.11, 脊索動物個体全体を用いた神経細胞ネットワークの網羅的解明

  Type of Award： Award from publisher, newspaper, foundation, etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• BASIC LABORATORY COURSE IN BIOSCIENCES

  2026

• GRADUATE RESEARCH ON INFORMATICS, MANAGEMENT, AND HUMAN SCIENCES A1

  2026

• DEVELOPMENTAL BIOLOGY

  2026

• BACHELOR'S THESIS

  2026

• TOPICS IN BIOSCIENCES AND INFORMATICS 1

  2026

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• biology course for beginner

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Within own ｆaculty, 2h, 200people

  biology

• basic biological course

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Laboratory work/practical work/exercise

• developmental biology

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture, Within own ｆaculty, 30people

• 生命情報実験

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty, 40people

• cell biology III

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture, Within own ｆaculty, 40people

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Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• International Tunicate Information System Meeting

  2010.04

  -

  Present

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• Zoological Sciety of Japan

  　

• Jananese Society of Developmental Biology

  　

• Society of Evolutionary Studies, Japan

  　

• The Molecular Biology Society of Japan

  　

• Genetic Meeting in Japan

  　

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2010.04

  -

  Present

  International Tunicate Information System Meeting Organizing Committee, International Tunicate Information System Meeting