KEIO RESEARCHERS INFORMATION SYSTEM

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1997.03

  Hokkaido University, Faculty of Science

  University, Graduated

• 2002.03

  Kyoto University, Graduate School, Division of Natural Science

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• PhD, Kyoto University, Coursework, 2002.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Developmental biology (Developmental Biology)

• Life Science / Morphology and anatomical structure

• Life Science / Biophysics

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• bioimaging

• tunicate

• mechanobiology

• evodev

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• 尾芽胚の曲がりを支える３Ｄ形態ロジック, 

  2016.04

  -

  2018.03

• Logic of the Elongation of Tailbud in Chordates, 

  2013

  -

  2014

• quantitative analysis of morphogenesis by whole-animal 4D imaging, 

  2009

  -

  2011

  　View Summary

  Tailbud feature binds various chordates into one common group because all chordates have tails at larval stage. In this study, to understand a comprehensive anatomy of tailbud embryo at single-cell-level, we reconstructed three-dimensional computer model from confocal image stacks of Ciona tailbud embryo (stage 22, 10.9 hpf at 18 °C) by using Tassy’s method (2006). As a result, we characterized unique cell arrangement in each tissue and revealed that the tailbud embryo consists of 1583 cells.

• Quantitative Analysis of Brain Vesicle Formation by 4D imaging, 

  2012

  -

  2013

  　View Summary

  Purpose of the Research Project
  
  Different region of central nervous system, fore brain, mid brain, hind brain and spinal cord originates from one neural tube at organogenesis period. Defects of neural tube formation cause severe diseases, including anencephaly and spina bifida. While understanding of differentiation at the molecular level has been deepened, the molecular mechanism of the morphogenesis of neural tubes at different regions remains to be clarified.
  
  One of chordate, ascidian a

• Robustness and Polymorphism of Individual Morphology in the Phylotypic Stage, 

  2012

  -

  2014

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Speed vs completeness: a comparative study of solitary and colonial tunicate embryogenesis

  Chiara Anselmi, Katherine J Ishizuka, Karla J Palmeri, Paolo Burighel, Ayelet Voskoboynik, Kohji Hotta, Lucia Manni

  Front Cell Dev Biol  ( 13 )  2025.03

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• Staring into a crystal ball: understanding evolution and development of in vivo aquatic organismal transparency

  Kohji Hotta, Shunsuke O. Miyashita, Kotaro Oka, Takumi T. Shito

  Frontiers in Ecology and Evolution 12-2024 2024.11

  Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted

  • Access to Document (DOI)

• Calcium-Induced Upregulation of Energy Metabolism Heats Neurons During Neural Activity

  Jayang Wu; Yutaka Shindo, Ph.D.; Kohji Hotta; Cong Vu; Kai Lu; Tetsuichi Wazawa; Takeharu Nagai

   2024.03

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• Multimodal factor evaluation system for organismal transparency by hyperspectral imaging

  Shito TT, Oka K, Hotta K.

  PLoS One.  2023.10

  Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

  • Access to Document (DOI)

• Intracellular Mg2+ protects mitochondria from oxidative stress in human keratinocytes.

  Keigo Fujita, Yutaka Shindo, Yuji Katsuta, Makiko Goto, Kohji Hotta, Kotaro Oka

  (Communications Biology)  6 2023.08

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• The role of the second-messenger in the beginning of Ciona metamorphosis

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2022

• Role of second messenger in the initiation of ascidian metamorphosis

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• 4D developmental mechanism for different morphology in each brain region

  Hotta, Kōji

  科学研究費補助金研究成果報告書 2019

• Developmental mechanism of central pattern generator regulating rhythmic locomotion

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2019

• Developmental mechanism of central pattern generator regulating rhythmic locomotion

  Hotta, Kohji

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2018

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 超透明生物！？ーガラスと同等の透明度を持つホヤ卵への進化と生存戦略

  紫藤拓巳、長谷川尚弘、岡浩太郎、堀田耕司

  academist Journal  2020.12

• Corrigendum to “Optical dissection of synaptic plasticity for early adaptation in Caenorhabditis elegans” [Neuroscience 428C (2020) 112–121] (Neuroscience (2020) 428 (112–121), (S0306452219308814), (10.1016/j.neuroscience.2019.12.026))

  Ashida K., Shidara H., Hotta K., Oka K.

  Neuroscience (Neuroscience)  434   212 - 213 2020.05

  ISSN  03064522

  　View Summary

  The author regret that, Fig. 5 in the above article was incorrect. The correct figure is published below. [Figure presented]

  • Access to Document (DOI)

• 細胞から個体へつなぐ組織としてのルール

  堀田耕司

  生命の教養学15組織としての生命　荒金 直人 編    3 - 22 2019

• ラマン分光イメージングによる非標識条件下でのホヤ胚の細胞分化識別

  HOTTA KOHJI

  比較内分泌学 (比較内分泌学)  42 ( 158 ) 52 - 53 2016.01

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

• Dual FRETイメージング法による細胞内シグナルの同時可視化生物物理トピック

  新野祐介、堀田耕司、岡浩太郎

  生物物理 50 ( 1 ) 028 - 029 2010

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 自律的にCa2+振動するホヤ幼生運動神経細胞MN2のイメージングおよびシングルセル解析

  堀田耕司

  研究会 ホヤの発生研究の歴史を振り返る, 

  2025.05

  , 

  Oral presentation (general)

• Functional analysis of RTTN in chordate ascidian development

  Sae J. Kashiro, Yuki S. Kogure, Takumi T. Shito, Marina Takahashi and Kohji Hotta

  The 85th Fujiwara Seminar, 

  2025.05

  , 

  Poster presentation

• 野外生物実習のオンライン教材VRinkai英語版の実装

  紫藤拓巳，戸塚望，上田理名，小暮悠暉，高橋茉莉奈，水谷日菜，古川亮平，倉石立，戸金大，藤田稜介，矢澤和明，藤澤侑典，内山正登，堀田耕司

  日本生物教育学会 第109回全国大会, 

  2025.03

  , 

  Oral presentation (general)

• ホヤ変態開始に伴う神経活動の複数同時計測

  土井愛美，戸塚望，堀田耕司

  日本動物学会関東支部第77回大会, 

  2025.03

  , 

  Poster presentation

• 自律的にCa2+振動するホヤ幼生運動神経細胞MN2 の イメージングおよびシングルセル解析

  堀田耕司

  2024 年度 生理学研究所研究会「極限環境適応」, 

  2024.11

  , 

  Oral presentation (invited, special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 脊索動物器官形成期における左右相称性補正機構の解明

  2024.04

  -

  2028.03

  Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research, Kohji Hotta, No Setting, Principal investigator

• Elucidating the Mechanism of Bilateral Symmetry Correction During Chordate Organogenesis

  2024.04

  -

  2028.03

  基盤研究(B), Principal investigator

• Elucidation of Self-transformation and Forces that Control Axial Rotation of Tailbud Embryo

  2023.04

  -

  2025.03

  Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research, Kohji Hotta, 学術変革領域研究(A), No Setting, Principal investigator

• Quantitative analysis of the mechanism of ascidian metamorphosis

  2021.04

  -

  2023.03

  Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, No Setting, Principal investigator

• Mechanism of shaping brain compartments

  2016.04

  -

  2019.03

  Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research, Kohji Hotta, 基盤研究(C), No Setting, Principal investigator

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 武田科学財団　一般研究奨励

  HOTTA KOHJI, 2008.11, 脊索動物個体全体を用いた神経細胞ネットワークの網羅的解明

  Type of Award： Award from publisher, newspaper, foundation, etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• BACHELOR'S THESIS

  2025

• ADVANCED TOPICS IN EVOLUTIONARY BIOLOGY

  2025

• ADVANCED LABORATORY COURSE IN BIOSCIENCES AND INFORMATICS D

  2025

• ADVANCED LABORATORY COURSE IN BIOSCIENCES AND INFORMATICS C

  2025

• BASIC LABORATORY COURSE IN BIOSCIENCES

  2025

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• basic biological course

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Laboratory work/practical work/exercise

• developmental biology

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture, Within own ｆaculty, 30people

• 生命情報実験

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty, 40people

• cell biology III

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture, Within own ｆaculty, 40people

• 生命情報特別講義

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture

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Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• International Tunicate Information System Meeting

  2010.04

  -

  Present

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• Zoological Sciety of Japan

  　

• Jananese Society of Developmental Biology

  　

• Society of Evolutionary Studies, Japan

  　

• The Molecular Biology Society of Japan

  　

• Genetic Meeting in Japan

  　

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2010.04

  -

  Present

  International Tunicate Information System Meeting Organizing Committee, International Tunicate Information System Meeting