Imoto, Masaya

写真a

Affiliation

Faculty of Science and Technology (Mita)

Position

Professor Emeritus

Career 【 Display / hide

  • 1980.04
    -
    1989.03

    キリンビール株式会社 ,勤務

  • 1989.04
    -
    1991.03

    慶應義塾大学理工学部 ,助手

  • 1991.04
    -
    1996.03

    慶應義塾大学理工学部 ,専任講師

  • 1996.04
    -
    2002.03

    慶應義塾大学理工学部 ,助教授

Academic Background 【 Display / hide

  • 1978.03

    Yamaguchi University, Faculty of Agriculture, 農芸化学科

    University, Graduated

  • 1980.03

    Yamaguchi University, Graduate School, Division of Agriculture, 農芸化学専攻

    Graduate School, Completed, Master's course

Academic Degrees 【 Display / hide

  • 農学 , The University of Tokyo, 1988.02

 

Research Areas 【 Display / hide

  • Chemical biology

 

Books 【 Display / hide

  • バイオの窓「大学における物取り研究」

    バイオサイエンスとインダストリー59: 43 (2001), 2001.03

Papers 【 Display / hide

  • Ktedonoketone and 2’-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi

    Igarashi Y., Yamamoto K., Ueno C., Yamada N., Saito K., Takahashi K., Enomoto M., Kuwahara S., Oikawa T., Tashiro E., Imoto M., Xiaohanyao Y., Zhou T., Harunari E., Oku N.

    Journal of Antibiotics (Journal of Antibiotics)  72 ( 9 ) 653 - 660 2019.09

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  00218820

     View Summary

    © 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. A thermophilic bacterium Thermosporothrix hazakensis NBRC 105916 which belongs to the class Ktedonobacteria was investigated to explore its biosynthetic potential of secondary metabolites. UV-guided fractionation led to the identification of a new benzenoid metabolite designated ktedonoketone (6) and an α-diketone metabolite 2’-oxosattabacin (7) along with five known compounds. Compound 7 was previously described as a synthetic compound, but this is the first finding as a natural product. Compound 7 induced adipocyte differentiation at 10–20 μM and autophagy at 1–10 μM. Compound 6 showed weak inducing activity of adipocyte differentiation. The biosynthetic origin of hazakacin (3), an acyloin-type compound, was elucidated by 13C-labeled precursor-feeding experiments.

  • CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

    Tsugawa H., Mori H., Matsuzaki J., Sato A., Saito Y., Imoto M., Suematsu M., Suzuki H.

    Autophagy (Autophagy)  15 ( 2 ) 242 - 258 2019.02

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  15548627

     View Summary

    © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Helicobacter pylori-derived CagA, a type IV secretion system effector, plays a role as an oncogenic driver in gastric epithelial cells. However, upon delivery into gastric epithelial cells, CagA is usually degraded by macroautophagy/autophagy. Hence, the induction of autophagy in H. pylori-infected epithelial cells is an important host-protective ability against gastric carcinogenesis. However, the mechanisms by which autophagosome-lysosome fusion is regulated, are unknown. Here, we report that enhancement of LAMP1 (lysosomal associated membrane protein 1) expression is necessary for autolysosome formation. LAMP1 expression is induced by nuclear translocated LRP1 (LDL receptor related protein 1) intracellular domain (LRP1-ICD) binding to the proximal LAMP1 promoter region. Nuclear translocation of LRP1-ICD is enhanced by H. pylori infection. In contrast, CAPZA1 (capping actin protein of muscle Z-line alpha subunit 1) inhibits LAMP1 expression via binding to LRP1-ICD in the nuclei. The binding of CAPZA1 to LRP1-ICD prevents LRP1-ICD binding to the LAMP1 proximal promoter. Thus, in CAPZA1-overexpressing gastric

  • Chemistry and biology for the small molecules targeting characteristics of cancer cells

    Imoto M.

    Bioscience, Biotechnology and Biochemistry (Bioscience, Biotechnology and Biochemistry)  83 ( 1 ) 10 - 19 2019

    Research paper (scientific journal), Single Work, Accepted,  ISSN  09168451

     View Summary

    © 2018 Informa UK Limited, trading as Taylor & Francis Group. Despite the marked progress of cancer research, cancer is the predominant cause of death in Japan, and therefore development of effective therapeutic drugs is expected. Chemical biology is a research field utilizing small molecules to investigate biological phenomena. One of the most important aims of chemical biology is to find the small molecules, and natural products are ideal screening sources due to their structural diversity. Therefore, natural product screening based on the progress of chemical biology prompted us to find small molecules targeting cancer characteristics. Another contribution of chemical biology is to facilitate the target identification of small molecule. Therefore, among a variety of methods to uncover protein function, chemical biology is a remarkable approach in which small molecules are used as probes to elucidate protein functions related to cancer development.

  • Studies of compound exerting synthetic lethality in beta-catenin mutated tumor cells

    Ikeda Hiroaki, Tashiro Etsu, Imoto Masaya

    CANCER SCIENCE 109   585 - 585 2018.12

    Research paper (scientific journal), Accepted,  ISSN  1349-7006

  • Chemical genomic analysis on autophagic regulation mechanism in human lung cancer A549 cells

    Kataura T., Imoto M.

    EUROPEAN JOURNAL OF CANCER 103   E67 - E67 2018.11

    Research paper (scientific journal), Accepted,  ISSN  0959-8049

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Papers, etc., Registered in KOARA 【 Display / hide

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Reviews, Commentaries, etc. 【 Display / hide

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Chemical Biology for Parkinson's disease

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 井本 正哉, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • Chemical Biological studies for autophagy

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 井本 正哉, Grant-in-Aid for Scientific Research (B), Principal Investigator

Intellectual Property Rights, etc. 【 Display / hide

  • 新規チロシンキナーゼ阻害剤の物質特許

    Registration No.:   1985

    Patent

  • イノスタマイシンの物質特許

    Registration No.:   1989

    Patent

  • デフォスタチンの物質特許

    Registration No.:   1996

    Patent

Awards 【 Display / hide

  • 住木・梅沢記念賞受賞

    2000.11, 日本抗生物質学術協議会

  • 住木・梅沢記念賞

    2000, 日本感染症医薬品協会(旧日本抗生物質学術協議会), 微生物由来細胞内情報伝達系に作用する物質の探索研究

  • 日本農芸化学会 奨励賞

    1995.03, 日本農芸化学会, 細胞内情報伝達系阻害剤の発見により受賞した。

  • 日本農芸化学会奨励賞受賞

    1995.03, 日本農芸化学会

 

Courses Taught 【 Display / hide

  • ADVANCED LABORATORY COURSE IN BIOSCIENCES AND INFORMATICS A

    2019

  • ADVANCED LABORATORY COURSE IN BIOSCIENCES AND INFORMATICS B

    2019

  • ADVANCED SCIENCES FOR DRUG DISCOVERY

    2019

  • BACHELOR'S THESIS

    2019

  • BASIC LABORATORY COURSE IN BIOSCIENCES

    2019

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Social Activities 【 Display / hide

  • バイオサイエンスとインダストリー誌

    1998.04
    -
    Present
  • 癌分子標的治療研究会

    1997
    -
    Present

Committee Experiences 【 Display / hide

  • 1998.04
    -
    Present

    トピックス委員, バイオサイエンスとインダストリー誌

  • 1997
    -
    Present

    会員, 癌分子標的治療研究会