Details of a Researcher - Mitsukura, Yasue

Mitsukura, Yasue

写真a

Affiliation: Faculty of Science and Technology, Department of System Design Engineering ( Yagami )

Position: Professor

Scopus Paper Info

Paper Count: 343 Citation Count: 2445 h-index: 20

Click to view the Scopus page. The data was downloaded from Scopus API in July 26, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Profile Summary 【 Display / hide 】

'''''''This laboratory focus on various signal processing and it’s applications. The current main topics of our research are bio-signal analysis (EEG, EMG, EOG, ECG, GSR, Body temp. Breath, Salivary amylase, NIRS, fMRI), brain computer interfaces, and impression & situation analysis of animation images.'''''''

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Other Affiliation 【 Display / hide 】

医学研究科, 研究科委員

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Research Areas 【 Display / hide 】

Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Electron device and electronic equipment (Electronic Device/Electronic Equipment)
Informatics / Intelligent informatics (Intelligent Informatics)
Informatics / Kansei informatics (Sensitivity Informatics/Soft Computing)

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Books 【 Display / hide 】

Psychological Impressions and Real-Time KANSEI Trajectory of Music Listeners Resulting from Differences in Piano Performance Methods

Shima Y., Sato T., Mitsukura Y., Toma T., Emotional Engineering Vol 9 Move Ahead Toward Self Satisfying Society Sss, 2022.01

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This study aimed to analyze how differences in piano techniques affect the KANSEI of music listeners. A prior timbre analysis of piano techniques was conducted using frequency analysis to investigate the effects of differences in performance techniques on music listeners; however, it was not possible to clearly capture the nuanced differences in performance techniques. It was found that even though the differences in the expressions and textures of sound could not be analyzed by frequency analyses, they did provide different psychological impressions to music listeners. To evaluate the impressions formed based on performance methods, we conducted KANSEI measurements using a simple electroencephalograph and an impression evaluation experiment using the semantic differential (SD) method. Our findings suggest that music listeners’ KANSEI, resulting from differences in performance methods, is related to changes in the tune of music.
- Access to Document (DOI)
脳波による脳内部情報の取得とその相関性～実社会で脳波診断は適用可能か

満倉靖恵, Bio-Clinica, 2020.04
様々な感性を定量化し、心と暮らしにフィードバック

満倉靖恵, 日経サイエンス, 2017.07
Review of Artifact Rejection Methods for Electroencephalographic Systems

2017.04
心と体が軽くなる万華鏡 DVDブック

MITSUKURA YASUE, 学研プラス, 2016.04

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Papers 【 Display / hide 】

EEG spectral biomarkers of postoperative delirium in spinal surgery: A high-resolution analysis

Gengtao Lin,Takahito Uchida,Kota Watanabe,Satoshi Suzuki,Masaya Nakamura,Yasue Mitsukura ,Hiroyoshi Takeuchi

PLoS One (Public Library of Science) 21 ( 7 ) 2026.07

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Background
Postoperative delirium is common in older adults following spinal surgery, yet current EEG-based detection methods rely on broad conventional frequency bands that may obscure clinically meaningful oscillatory changes. More granular spectral approaches may reveal candidate frequency-specific features that could improve diagnostic performance.

Methods
We recorded single-electrode frontal EEG (Fp1) from 47 patients at four perioperative timepoints and compared traditional band-level power with high-resolution 1-Hz spectral analysis (1–45 Hz). Group differences were evaluated using non-parametric statistics with FDR correction, and diagnostic accuracy was assessed using AUROC and threshold-optimized metrics. All diagnostics thresholds were derived and evaluated in the same dataset.

Results
Seven patients (14.9%) developed delirium. Conventional band analysis detected only reduced theta power during active delirium (|r| = 0.31; AUROC = 0.53). In contrast, 1-Hz analysis revealed a richer pattern: elevated 1-Hz power (|r| = 0.27), reduced 3–7 Hz power (|r| = 0.25–0.27), and increased 14–15 Hz power (|r| = 0.22–0.26). The 23-Hz narrow-band feature achieved the best discrimination (AUROC = 0.74), despite showing no significant effect within the traditional beta band (12–30 Hz). Several frequencies remained altered even after clinical resolution of delirium.

Conclusions
In this exploratory analysis, high-resolution spectral analysis identified candidate frequency-specific EEG features that distinguished delirium cases more accurately than conventional frequency bands in this cohort. Broadband averaging may not detect frequency-specific oscillatory patterns; adopting finer spectral resolution could enhance the utility of single-channel EEG for routine clinical monitoring.
The indirect association of subjective work performance with sleep quality and wellbeing among high-stress workers in Japan: a cross-sectional study

Anna Kubota, Hisateru Tachimori, Akihiro Koreki, Yoshiaki Kanamori, Manae Uchibori, Shiyori Usune, Mitsuhiro Sado, Yasue Mitsukura, Akira Ninomiya, Ryutaro Shirahama, Akihiro Fujimoto, Kanako Inabe, Hiroaki Miyata, Masaru Mimura

Frontiers in Public Health (Frontiers Media S.A) 14 2026.07

Research paper (scientific journal)

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In today’s fast-paced and demanding working society, promoting wellbeing has become increasingly important. While sleep quality is widely recognized as a critical determinant of wellbeing, the specific pathways linking the two remain underexplored, particularly in high-stress occupational settings. Understanding these associations may enable the development of more effective strategies for promoting wellbeing in this population. Recently, work performance (presenteeism) has garnered attention for its potential intermediary role, as it may play a pivotal role in supporting employees’ wellbeing. At the same time, work performance itself is known to be closely related to sleep disturbances. However, the mediating effect has not been thoroughly examined. This study aimed to investigate whether presenteeism serves as a link in the association between sleep quality and wellbeing in a working population. A total of 129 high-stress office workers in Japan participated in this observational study. Sleep quality, presenteeism, and wellbeing were assessed using validated measures, and mediation analysis was conducted using the PROCESS macro with bootstrap samples to estimate indirect associations. Results revealed associations between sleep quality and presenteeism (r = − 0.306, p < 0.01), as well as between sleep quality and wellbeing (r = − 0.213, p < 0.01), indicating that poorer sleep (i.e., higher PSQI scores) was linked to both higher presenteeism (lower performance) and reduced wellbeing. Furthermore, presenteeism was found to statistically mediate the association between sleep quality and wellbeing. Even after adjusting for multiple covariates (age, sex, years of service, weekly working hours, occupational position, smoking status, and alcohol consumption), a significant indirect association was observed (Estimate = −0.446, 95% CI [−0.919, −0.072]). These findings suggest that the importance of work performance as a potential intermediary factor between sleep and wellbeing among high-stress workers. This study provides novel insights into the occupational mechanisms associated with sleep quality and wellbeing and highlights the importance of addressing presenteeism as a critical intervention target in occupational health.
- Access to Document (DOI)
Effects of Microplastic Accumulation on Hepatic Immune Function and In-flammation

Hayato Ikeda, Yasue Mitsukura

2026.03

Research paper (conference, symposium, etc.)
Feature Extraction for Estimating Blood Noradrenaline Fluctuations Using EEG

Yuhei Suzuki, Yasue Mitsukura

2026.02
Unexpectedly High Accumulation of Nanoplastics in the Human Placenta: Higher Levels then in the Brain and Liver

Yasue Mitsukura

2026.01

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Papers, etc., Registered in KOARA 【 Display / hide 】

Field survey on impact of living environments on brain, cardiovascular, respiratory and locomotive system, and co-benefit evaluation of disease and long-term care prevention

Mitsukura, Yasue

科学研究費補助金研究成果報告書 2021
Sleep stage detection using only heart rate (本文)

Mitsukura, Yasue

(慶應義塾大学大学院医学研究科) 2020
心拍のみを用いた睡眠の段階判定

Mitsukura, Yasue

(慶應義塾大学大学院医学研究科) 2020
心拍のみを用いた睡眠の段階判定

Mitsukura, Yasue

(慶應義塾大学大学院医学研究科) 2020
A study on human motion model and force control based life support for ADL

Mitsukura, Yasue

科学研究費補助金研究成果報告書 2017

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Reviews, Commentaries, etc. 【 Display / hide 】

ウェアラブルデバイスによる妊娠母体概日リズムの検討

加藤恭介, 木内謙一郎, 春日義史, 池ノ上学, 勝俣良紀, 有光威志, 飛彈麻里子, 吉野純, 満倉靖恵, 伊藤裕, 林香

糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会) 25 ( 3 ) S - 108 2025.10

ISSN 1347-9172
腹腔鏡トレーニングにおける,指導員の声掛けによる心理的影響の考察(Consideration of the Psychological Effects of Instructor Verbal Guidance in Laparoscopic Training)

塩野泰良, 堀周太郎, 北郷実, 当麻哲哉, 杉山佑, 増田朗菜, 満倉靖恵, 加藤源俊, 藤野明浩, 北川雄光

日本消化器外科学会総会 ((一社)日本消化器外科学会) 80回 1543 - 1544 2025.07
健康に長生きできる住まいと住まい方を考える　生体信号が全てを語る、ごきげんな住まいと住まい方

満倉靖恵

日本応用老年学会大会 ((一社)日本応用老年学会) 19回 26 - 26 2024.10
生体情報計測に基づく体調モニタリングの実用性検討

青木駿介, 満倉靖恵

日本応用老年学会大会 ((一社)日本応用老年学会) 19回 36 - 36 2024.10
就寝前の日記習慣が睡眠の質に与える影響

塚田海斗, スマリ・ブライアン , 満倉靖恵

日本応用老年学会大会 ((一社)日本応用老年学会) 19回 108 - 108 2024.10

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Presentations 【 Display / hide 】

Influence of Meningeal Lymphatic Vessels on Brain Mechanisms

Masashi Matsuoka, Yasue Mitsukura, Tomoe Ishikawa, Masato Yasui

[Domestic presentation] Proceedings for Annual Meeting of The Japanese Pharmacological Society,

2019.03
,
Oral presentation (general), Japanese Pharmacological Society

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<p>The central nervous system has been considered as an organ devoid of lymphatic vessels. Meningeal lymphatic vessels were discovered and it is thought that elucidating mechanism of these vessels contributes to the studies on neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis. Previous researches focused on material flow in the brain and excretion of proteins and immune cells. There are few researches directly investigating the relationship between the brain and meningeal lymphatic vessels. Our research focused on structure of brain cells and neural activities. Meningeal lymphatic vessels connect to the deep cervical lymph nodes (dcLNs). Ligating efferent lymphatic vessels of dcLNs lead to the reduction of cerebrospinal fluid (CSF) drainage. Electrocorticography (ECoG) was recorded for 8 weeks and glial cells and synapses were immunostained in mice 1, 4 and 8 weeks after ligation. Results showed that reducing lymphatic flow concerned neural activities.</p>
- Access to Document (DOI)
- CiNii Research
Can We Separate the Kind of Drinks using only EEG

Takahiro Oohashi and Yasue Mitsukura

[International presentation] Proc. of The 3rd aquaphotphotomics International Symposium,

2018.12
,
Oral presentation (general)
Effect on the Lighting Condition for Human' Emotion and Task Efficiency Using Electroencephalogram

Kento Horita and Yasue Mitsukura

[International presentation] Proc. of The 3rd aquaphotphotomics International Symposium,

2018.12
,
Oral presentation (general)
Sleep Quality and Workplace Productivity Evaluation on the Wooden Interior

Keiichi Sato, Takahiro Asano, and Yasue mitsukura

[International presentation] Proc. of The 3rd aquaphotphotomics International Symposium,

2018.12
,
Oral presentation (general)
Extraction of Time Delay in Stress Fluctuation During Excavation Work for KANSEI Feedback Control System in Hydraulic Excavators

Risa Nara, Yasue Mitsukura, Nozomu Hamada

[Domestic presentation] 計測自動制御学会システム・情報部門学術講演会2018,

2018.11
,
Oral presentation (invited, special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Neuro-Cognitive Task Analysisによる手術認知プロセスの形式知化手法の開発

2025.04

-

2028.03

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting

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本研究では、簡易脳波測定器を用いてリアルタイムで認知負荷量を推定し、認知作業分
析を実施する。これにより、手術における認知プロセスの形式知化と構造化を図り、サー
ジカルインテリジェンスのレポジトリーを構築することを目的とする。また、手術中の認
知負荷が手術成績に与える影響について探索的な分析を行い、これらの結果を基に認知プ
ロセスの修練に特化した動画教材を開発する。
Elucidation of the effects of violet light on sleep and biological rhythms in the elderly

2022.04

-

2025.03

Grants-in-Aid for Scientific Research, Ashida Kozo, Grant-in-Aid for Scientific Research (C), No Setting

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This clinical study was conducted using polysomnography to determine the effect of 3 hours of violet light irradiation during the day (11:00 am to 2:00 pm) on sleep quality. The results showed that the percentage of deep sleep (N3) during non-REM sleep significantly increased in the violet light irradiation group compared to the control group (p=0.03). On the other hand, there was no significant difference in total sleep time (TST). These results suggest that light may be associated with mechanisms that affect biological rhythms such as the sleep-wake cycle via the suprachiasmatic nucleus (SCN) and other organs.
Contactless Heart Rate Monitoring and Sleep Stage Classification Using Technology for Daily Monitoring.

2021.04

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2025.03

Keio University, Grants-in-Aid for Scientific Research, MITSUKURA YASUE, Grant-in-Aid for Scientific Research (B), No Setting

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This study developed a system for classifying sleep into five stages using only heart rate data. In the first year, we simultaneously measured heart rate and polysomnography (PSG) to extract features necessary for classification, leading to a single patented equation. In the second year, we applied a non-contact sensor attached to bed legs, enabling heart rate detection and sleep staging simply by lying in bed. PSG validation confirmed the accuracy of this approach. Tests with healthy individuals in their 20s to 40s demonstrated the feasibility of five-stage sleep classification using heart rate alone. In the third year, we extended the study to patients with various conditions and to primate models. Results showed that the system was not effective in individuals with heart rate abnormalities, which we identified as a limitation for further research.
Visual Attention Estimation and Attention Retargeting for First Person Vision

2018.04

-

2021.03

Okayama Prefectural University, Grants-in-Aid for Scientific Research, Takimoto Hironori, Grant-in-Aid for Scientific Research (C), No Setting

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Wearable transmissive displays equipped with small cameras, such as smart glasses, are attracting attention as new devices that contribute to realizing an information environment in harmony with people. We have worked on realizing the technique to precisely estimate visual attention, which is an important cue for estimating a person's internal state (intention and interest) from the first-person video captured by a wearable camera. We also studied the establishment of a gaze guidance technology based on visual attention and visual threshold information presentation to realize a gaze guidance technology for wearable transmissive displays, aiming to recognize an information presentation space that supports daily activities for humans.
Field survey on Impact of living environments on brain, cardiovascular, respiratory and locomotive system, and co-benefit evaluation of disease and long-term care prevention

2017.05

-

2022.03

Keio University, Grants-in-Aid for Scientific Research, Ikaga Toshiharu, Grant-in-Aid for Scientific Research (S), No Setting

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This study focuses on the effect of extending the healthy life span, which is a Co-Benefit by improving the living environment, and by conducting a large-scale field survey and follow-up / intervention survey, the living environment is affected by brain function, blood pressure, cardiovascular disease, and respiratory disease. Quantitatively clarified the effects on health such as athletic ability and need for nursing care. In the survey targeting the youth to middle age, in addition to verifying the relationship between the home environment and the resident's home blood pressure, brain MRI imaging data, sleep state, body temperature, physical activity, heart rate, respiratory function, etc. We verified the intellectual productivity in the office. Since daytime intellectual productivity is affected not only by the office environment itself, but also by sleep and rest at home the day before, we conducted a subject experiment on the synergistic effect of a good home / office environment.

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Works 【 Display / hide 】

感性アナライザ

ゆびほか,

2017.04

-

Present
,
Other
感性アナライザ田原総一朗氏との対談「脳波を読んで心を可視化する」

潮,

2017

-

Present
,
Other, Joint

　View Details

田原総一朗氏との対談「脳波を読んで心を可視化する」
AGC中央研究所での講演「脳波を用いた感性取得とその応用」

2016.12

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Present
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Other, Single
第７回慶應義塾生命科学シンポジウムでの講演食と医学フォーラム

2016.12

-

Present
,
Other, Joint
航空自衛隊　航空医学実験隊での講演

2016.11

-

Present
,
Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

乗り物振動検出方法及び乗り物振動検出装置

Date applied： 5802024 2011.03

Patent, Joint

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Awards 【 Display / hide 】

守田科学技術賞

2014
DIGITAL CONTENTS EXPO 2012

MITSUKURA YASUE, 2012.10, 経済産業省

Type of Award： Other

　View Description

DIGITAL CONTENTS EXPO 2012
優秀論文発表賞

MITSUKURA YASUE, 2012.08, 電気学会電子・情報・システム部門

Type of Award： Award from Japanese society, conference, symposium, etc.
Best Paper Award in Multimedia and Systems

MITSUKURA YASUE, 2011.12, A proposal of model-based alignment using swarm intelligence and condensation

Type of Award： International academic award (Japan or overseas)
優秀論文賞

MITSUKURA YASUE, 2011.11, 顔面運動推定に基づく3DCGモデル操作システム

Type of Award： Award from Japanese society, conference, symposium, etc.