Papers - Nishiyama, Shigeru

A synthetic approach to carbazoles using electrochemically generated hypervalent iodine oxidant.

NISHIYAMA SHIGERU

Tetrahedron 66 ( 52 ) 9779-9784 2010

Research paper (scientific journal), Joint Work, Accepted

Synthesis of tetrahydropyrroloiminoquinone alkaloids based on electrochemically generated hypervalent iodine oxidative cyclization.

NISHIYAMA SHIGERU

Org. Lett. 12 ( 3 ) 436-439 2010

Research paper (scientific journal), Joint Work, Accepted

Electrochemical construction of the diaryl ethers: a synthetic approach to o-methylthalibrine.

Y. Naito, T. Tanabe, Y. Kawabata, Y. Ishikawa, S. Nishiyama

Tetrahedron Lett. 51 ( 36 ) 4776-4778 2010

Research paper (scientific journal), Joint Work, Accepted

A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.

T. Saitoh, C. Shimada, M. Takeiri, M. Shiino, S. Ohba, R. Obata, Y. Ishikawa, K. Umezawa, S. Nishiyama

Bioorganic Medicinal Chemistry Letters 20 ( 19 ) 5638-5642 2010

Research paper (scientific journal), Joint Work, Accepted

Electrochemical construction of the diaryl ethers: a synthetic approach to o-methylthalibrine.

NISHIYAMA SHIGERU

Tetrahedron Lett. 51 ( 36 ) 4776 – 4778 2010

Research paper (scientific journal), Joint Work, Accepted

A new NF-kappaB inhibitor based on the amino-epoxyquinol core of DHMEQ.

NISHIYAMA SHIGERU

Bioorg. Med. Chem. Lett. 20 ( 19 ) 5638-5642 2010

Research paper (scientific journal), Joint Work, Accepted

Electrochemical multi-step approach towards Isodityrosine, a component of biologically important cyclic peptides.

NISHIYAMA SHIGERU

CS Transactions (The 216th ECS Meeting)  21   91-95 2009

Research paper (conference, symposium, etc.), Joint Work, Accepted

Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation.

NISHIYAMA SHIGERU

HETEROCYCLES 77 ( 2 ) 759-765 2009

Research paper (scientific journal), Joint Work, Accepted

A synthetic study on gymnastatins F and Q: the tandem Michael and aldol reaction approach.

NISHIYAMA SHIGERU

Tetrahedron Lett. 50   3191 – 3194 2009

Research paper (scientific journal), Joint Work, Accepted

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB.

NISHIYAMA SHIGERU

Bioorg. Med. Chem. Lett. 19   1726 – 1728 2009

Research paper (scientific journal), Joint Work, Accepted

Total synthesis of (±)-megistophylline I.

NISHIYAMA SHIGERU

Tetrahedron Lett. 50 ( 23 ) 2801 – 2804 2009

Research paper (scientific journal), Joint Work, Accepted

Efficient synthesis of (±)-parasitenone, a novel inhibitor of NF-κB.

NISHIYAMA SHIGERU

T Bioorg. Med. Chem. Lett. 19   5383-5386 2009

Research paper (scientific journal), Joint Work, Accepted

Palladium-catalyzed aromatic C-H halogenation with hydrogen halides by means of electrochemical oxidation.

NISHIYAMA SHIGERU

J. Am. Chem. Soc. 131 ( 32 ) 11310 – 11311 2009

Research paper (scientific journal), Joint Work, Accepted

隣接位に酸素官能基を有するビシナルジブロミドの脱離反応を利用した生物活性天然物の全合成研究.

NISHIYAMA SHIGERU

有機合成化学協会誌 66 ( 25 ) 139-147 2008.02

Research paper (scientific journal), Joint Work, Accepted

Electrochemical behavior of thallium ion in organic solvents and its application to organic synthesis.

NISHIYAMA SHIGERU

ECS Transactions (The 213th Meeting of the Electrochemical Society.)  13 ( 20 ) 7-12 2008

Research paper (conference, symposium, etc.), Joint Work, Accepted

Synthesis and antitumor activity of combretastatin D-4.

NISHIYAMA SHIGERU

HETEROCYCLES 75 ( 25 ) 291-296 2008

Research paper (scientific journal), Joint Work

　View Summary

Combretastatin D-4 1 was synthesized using electrochemical
dimerization of phenols as the key step. Anodic oxidation of bromochloro-phenol 7 provided the corresponding diaryl ether 8. Manipulation of the two hydroxyl groups differenciated, provided the seco-acid, which on Mitsunobu reaction gave the target molecule. Its biological assay showed new potent inhibitory activity against cellular proliferation of human HT-29 colon carcinoma cells.

08010333052520080317173420PDF1.pdf

Oxidative access to quinolinone derivatives with simultaneous rearrangement of functional groups.

NISHIYAMA SHIGERU

Synlett  ( 1 ) 134-136 2008

Research paper (scientific journal), Joint Work, Accepted

　View Summary

Hypervalent iodine-mediated oxidation of aromatic compounds carrying methoxyamide side chains provided the corresponding quinolinones. The reactive point was at the para position to electron-donating groups (such as a MeO group) in the aromaticring. Introduction of AcO or halogen groups to this position resultedin a cyclization, concomitant with rearrangement of the functional group.

08010333052620080317173720PDF1.pdf

Effects of aromatic substituents of electrochemically generated hypervalent iodine oxidant on oxidation reactions.

NISHIYAMA SHIGERU

HETEROCYCLES 75 ( 8 ) 1997 - 2003 2008

Research paper (scientific journal), Single Work

DBU Promoted elimination reactions of vicinal dibromoalkanes mediated by adjacent o-functional groups and applications to the synthesis of biologically active natural products.

NISHIYAMA SHIGERU

Synlett    3091-3105 2008

Research paper (scientific journal), Joint Work, Accepted

Synthesis of a spiroacetal moiety of antitumor antibiotic ossamycin by anodic oxidation.

NISHIYAMA SHIGERU

Tetrahedron 64   9495 - 9506 2008

Research paper (scientific journal), Joint Work, Accepted