Papers - Nishiyama, Shigeru

Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions

Zhang Y., Sugai T., Yamamoto T., Yamamoto N., Kutsumura N., Einaga Y., Nishiyama S., Saitoh T., Nagase H.

ChemElectroChem (ChemElectroChem)  6 ( 16 ) 4194 - 4198 2019

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© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An oxidative cleavage reaction of the acyl−carbon bond in phenylacetone derivatives under cathodic reduction is reported. This particular transformation is driven by the cathodic reduction of dissolved molecular oxygen to superoxide anions. Various cathode materials were examined, and we discovered that boron-doped diamond (BDD) enables highly efficient molecular conversion, owing to BDD's outstanding electrochemical property for utilizing the small amounts of molecular oxygen effectively. The scope of the reaction is broad and can be applied to a variety of substrates, ranging from ketones to esters and amides. As an electric current is directly employed to generate the superoxide anion, the reaction is metal- and catalyst-free. Electro-organic synthesis using the carbon-based BDD electrode thus provides access to sustainable molecular transformations.

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Near-Infrared Bioluminescence Imaging with a through-Bond Energy Transfer Cassette

Abe M., Nishihara R., Ikeda Y., Nakajima T., Sato M., Iwasawa N., Nishiyama S., Paulmurugan R., Citterio D., Kim S., Suzuki K.

ChemBioChem (ChemBioChem)  20 ( 15 ) 1919 - 1923 2019

ISSN  14394227

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© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A coelenterazine (CTZ) analogue emitting near-infrared (NIR) bioluminescence was synthesized for through-bond energy transfer (TBET)-based imaging modalities. The analogue, named Cy5-CTZ, was prepared by conjugating cyanine-5 (Cy5) dye to CTZ through an acetylene linker. This novel derivative is intrinsically fluorescent and emits NIR-shifted luminescence upon reacting with an appropriate luciferase, the Renilla luciferase. This Cy5-CTZ substrate is optically stable in physiological samples and rapidly permeabilize through the plasma membrane into the cytosolic compartment of live cells.

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Highly bright and stable NIR-BRET with blue-shifted coelenterazine derivatives for deep-tissue imaging of molecular events in vivo

Nishihara R., Paulmurugan R., Nakajima T., Yamamoto E., Natarajan A., Afjei R., Hiruta Y., Iwasawa N., Nishiyama S., Citterio D., Sato M., Kim S., Suzuki K.

Theranostics (Theranostics)  9 ( 9 ) 2646 - 2661 2019

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© Ivyspring International Publisher. Background: Bioluminescence imaging (BLI) is one of the most widely used optical platforms in molecular imaging, but it suffers from severe tissue attenuation and autoluminescence in vivo. Methods: Here, we developed a novel BLI platform on the basis of bioluminescence resonance energy transfer (BRET) for achieving a ∼300 nm blue-to-near infrared shift of the emission (NIR-BRET) by synthesizing an array of 18 novel coelenterazine (CTZ) derivatives, named “Bottle Blue (BBlue)” and a unique iRFP-linked RLuc8.6-535SG fusion protein as a probe. Results: The best NIR-BRET was achieved by tuning the emission peaks of the CTZ derivatives to a Soret band of the iRFP. In mammalian cells, BBlue2.3, one of the CTZ derivatives, emits light that is ∼50-fold brighter than DBlueC when combined with RLuc8.6-535SG, which shows stable BL kinetics. When we used a caged version of BBLue2.3, it showed a BL half decay time of over 60 minutes while maintaining the higher signal sensitivity. This NIR BL is sufficiently brighter to be used for imaging live mammalian cells at single cell level, and also for imaging metastases in deep tissues in live mice without generating considerable autoluminescence. A single-chain probe developed based on this BLI platform allowed us to sensitively image ligand antagonist-specific activation of estrogen receptor in the NIR region. Conclusion: This unique optical platform provides the brightest NIR BLI template that can be used for imaging a diverse group of cellular events in living subjects including protein‒protein interactions and cancer metastasis.

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Electrochemical Pinacol Coupling of Acetophenone Using Boron-Doped Diamond Electrode

Nakahara K., Naba K., Saitoh T., Sugai T., Obata R., Nishiyama S., Einaga Y., Yamamoto T.

ChemElectroChem (ChemElectroChem)  6 ( 16 ) 4153 - 4157 2019

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© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An electrochemical pinacol coupling reaction of acetophenone using a boron-doped diamond (BDD) electrode has been reported. This transformation is driven by the one-electron reduction of acetophenone on the BDD cathode, followed by an intermolecular radical coupling. Owing to the BDD's outstanding electrochemical properties, the pinacol-type compound has been obtained in good conversion yield. The roles of a supporting electrolyte and solvent were addressed; (1) lithium ions contribute to increase in the reactivity of the radical intermediate. (2) Addition of water promotes the electron transfer process at the BDD surface. The reaction is relatively tolerant to para-substituted acetophenone derivatives. Since electric current is directly employed as reducing reagents to generate a radical intermediate, the reaction is metal-free, sustainable, and inherently safe.

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Azide- and Dye-Conjugated Coelenterazine Analogues for a Multiplex Molecular Imaging Platform

Nishihara R., Hoshino E., Kakudate Y., Kishigami S., Iwasawa N., Sasaki S., Nakajima T., Sato M., Nishiyama S., Citterio D., Suzuki K., Kim S.

Bioconjugate Chemistry (Bioconjugate Chemistry)  29 ( 6 ) 1922 - 1931 2018.06

ISSN  10431802

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© 2018 American Chemical Society. Native coelenterazine (nCTZ) is a common substrate to most marine luciferases and photoproteins. In this study, nine novel dye- and azide-conjugated CTZ analogues were synthesized by conjugating a series of fluorescent dyes or an azide group to the C-2 or C-6 position of the nCTZ backbone to obtain bulkiness-driven substrate specificity and potential chemiluminescence/bioluminescence resonance energy transfer (C/BRET). The investigation on the optical properties revealed that azide-conjugated CTZs emit greatly biased bioluminescence to ALucs and ca. 130 nm blue-shifted bioluminescence with RLuc8.6 in living animal cells or lysates. The corresponding kinetic study explains that azide-conjugated CTZ exerts higher catalytic efficiency than nCTZ. Nile red-conjugated CTZ completely showed red-shifted CRET spectra and characteristic BRET spectra with artificial luciferase 16 (ALuc16). No or less spectral overlap occurs among [Furimazine-NanoLuc], [6-N 3 -CTZ-ALuc26], [6-pi-OH-CTZ-RLuc8.6], and [6-N 3 -CTZ-RLuc8.6] pairs, because of the substrate-driven luciferase specificity and color shifts, providing a crosstalk-free multiplex bioassay platform. The unique bioluminescence system appends a new toolbox to bioassays and multiplex molecular imaging platforms. This study is the first example that systematically synthesized fluorescent dye-conjugated CTZs and applied them for a bioluminescence assay system.

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Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling

Ota E., Usui K., Oonuma K., Koshino H., Nishiyama S., Hirai G., Sodeoka M.

ACS Chemical Biology (ACS Chemical Biology)  13 ( 4 ) 876 - 880 2018.04

ISSN  15548929

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© 2018 American Chemical Society. Photoaffinity labeling (PAL) is an important tool in chemical biology research, but application of α-ketoamides for PAL has been hampered by their photoinstability. Here, we show that 2-thienyl-substituted α-ketoamide is a superior photoreactive group for PAL. Studies with a series of synthetic mannose-conjugated α-ketoamides revealed that 2-thienyl substitution of α-ketoamide decreased the electrophilicity of the keto group and reduced the rate of photodegradation. Mannose-conjugated thienyl α-ketoamide showed greater concanavalin A labeling efficiency than other alkyl or phenyl-substituted α-ketoamides. In comparison with representative conventional photoreactive groups, 2-thienyl ketoamide showed reduced labeling of nontarget proteins, probably owing to its lower hydrophobicity.

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Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution

Kitada N., Saitoh T., Ikeda Y., Iwano S., Obata R., Niwa H., Hirano T., Miyawaki A., Suzuki K., Nishiyama S., Maki S.

Tetrahedron Letters (Tetrahedron Letters)  59 ( 12 ) 1087 - 1090 2018.03

ISSN  00404039

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© 2018 The synthesis and bioluminescence of allyl-substituted luciferin derivatives as substrates for firefly luciferase are reported. The allylation of luciferins induced bathochromic shift (15–40 nm) of the bioluminescence emission. Upon combination with other chemical modifications for bioluminescence wavelength tuning, novel red emitting luciferin analogues were obtained with emission maxima at 685 and 690 nm.

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Highly Sensitive Bioluminescent Probe for Thiol Detection in Living Cells

Hemmi M., Ikeda Y., Shindo Y., Nakajima T., Nishiyama S., Oka K., Sato M., Hiruta Y., Citterio D., Suzuki K.

Chemistry - An Asian Journal (Chemistry - An Asian Journal)  13 ( 6 ) 648 - 655 2018.03

ISSN  18614728

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© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The sensitive detection of thiols including glutathione and cysteine is desirable owing to their roles as indispensable biomolecules in maintaining intracellular biological redox homeostasis. Herein, we report the design and synthesis of SEluc-1 (sulfinate ester luciferin), a chemoselective probe exhibiting a ratiometric and turn-on response towards thiols selectively in fluorescence and bioluminescence, respectively. The probe, which was designed based on the “caged” luciferin strategy, displays excellent selectivity, high signal/noise ratio (>240 in the case of bioluminescence), and a biologically relevant limit of detection (LOD, 80 nm for cysteine), which are all desirable traits for a sensitive bioluminescent sensor. SEluc-1 was further applied to fluorescence imaging of thiol activity in living human cervical cancer HeLa cell cultures, and was successfully able to detect fluctuations in thiol concentrations induced by oxidative stress in a bioluminescent assay utilizing African green monkey fibroblast COS-7 cells and human breast adenocarcinoma MCF-7 cells.

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An allylated firefly luciferin analogue with luciferase specific response in living cells

Ikeda Y., Saitoh T., Niwa K., Nakajima T., Kitada N., Maki S., Sato M., Citterio D., Nishiyama S., Suzuki K.

Chemical Communications (Chemical Communications)  54 ( 14 ) 1774 - 1777 2018

ISSN  13597345

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© The Royal Society of Chemistry 2018. An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated. When applied to cellular imaging in combination with Eluc, which is one of the commercially available luciferases, this analogue displayed a luciferase-specific bioluminescence signal with prolonged emission (>100 min).

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Application of electrochemically generated hypervalent iodine oxidant to natural products synthesis.

NISHIYAMA SHIGERU

Electrochemistry 81 ( 5 ) 319-324 2013.05

Research paper (scientific journal), Joint Work

ダイヤモンド電極を用いた環境低負荷型有機電解反応

NISHIYAMA SHIGERU

ニューダイヤモンド 107 ( 10 ) 20-23 2012

Research paper (scientific journal), Joint Work

Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide.

NISHIYAMA SHIGERU

Bioorg. Med. Chem. Lett. 22 ( 1 ) 164-167 2012

Research paper (scientific journal), Joint Work, Accepted

Anodic oxidation on a boron-doped diamond electrode mediated by methoxy radicals. Angew. Chem. Int. Ed. Engl.

NISHIYAMA SHIGERU

Angew. Chem. Int. Ed. Engl. 51 ( 22 ) 5443-5446 2012

Research paper (scientific journal), Joint Work, Accepted

Oxidative cyclization reactions of tryptamine utilizing hyper-valent iodobenzene in routes for pyrroloindole alkaloid synthesis.

NISHIYAMA SHIGERU

Synthesis  2012

Research paper (scientific journal), Joint Work

Total syntheses of amphidinolides B, G, and H.

NISHIYAMA SHIGERU

Angew. Chem. Int. Ed. Engl. 51 ( 39 ) 9877-9880 2012

Research paper (scientific journal), Joint Work, Accepted

Catalytic electrochemical C-H iodination and one-pot arylation by on/off switching of electric current.

NISHIYAMA SHIGERU

J. Org. Chem. 77 ( 17 ) 7718-7724 2012

Research paper (scientific journal), Joint Work, Accepted

Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components.

NISHIYAMA SHIGERU

Bioorg. Med. Chem. Lett. 21 ( 21 ) 6293-6296 2011

Research paper (scientific journal), Joint Work, Accepted

Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone.

NISHIYAMA SHIGERU

Inflammation Research 60 ( 9 ) 879 – 888 2011

Research paper (scientific journal), Joint Work, Accepted

Synthesis of key fragments of amphidinolide Q — A cytotoxic 12-membered macrolide. K. Kawa, A. Hara, Y. Ishikawa, and S. Nishiyama

NISHIYAMA SHIGERU

Molecules 16 ( 7 ) 5422-5436 2011

Research paper (scientific journal), Joint Work, Accepted

Synthesis of the C7-26 fragment of amphidinolides G and H.

NISHIYAMA SHIGERU

Org. Lett. 13 ( 15 ) 4036-4039 2011

Research paper (scientific journal), Joint Work

A synthetic approach to carbazoles using electrochemically generated hypervalent iodine oxidant.

NISHIYAMA SHIGERU

Tetrahedron 66 ( 52 ) 9779-9784 2010

Research paper (scientific journal), Joint Work, Accepted

Synthesis of tetrahydropyrroloiminoquinone alkaloids based on electrochemically generated hypervalent iodine oxidative cyclization.

NISHIYAMA SHIGERU

Org. Lett. 12 ( 3 ) 436-439 2010

Research paper (scientific journal), Joint Work, Accepted

Electrochemical construction of the diaryl ethers: a synthetic approach to o-methylthalibrine.

Y. Naito, T. Tanabe, Y. Kawabata, Y. Ishikawa, S. Nishiyama

Tetrahedron Lett. 51 ( 36 ) 4776-4778 2010

Research paper (scientific journal), Joint Work, Accepted

A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.

T. Saitoh, C. Shimada, M. Takeiri, M. Shiino, S. Ohba, R. Obata, Y. Ishikawa, K. Umezawa, S. Nishiyama

Bioorganic Medicinal Chemistry Letters 20 ( 19 ) 5638-5642 2010

Research paper (scientific journal), Joint Work, Accepted

Electrochemical construction of the diaryl ethers: a synthetic approach to o-methylthalibrine.

NISHIYAMA SHIGERU

Tetrahedron Lett. 51 ( 36 ) 4776 – 4778 2010

Research paper (scientific journal), Joint Work, Accepted

A new NF-kappaB inhibitor based on the amino-epoxyquinol core of DHMEQ.

NISHIYAMA SHIGERU

Bioorg. Med. Chem. Lett. 20 ( 19 ) 5638-5642 2010

Research paper (scientific journal), Joint Work, Accepted

Electrochemical multi-step approach towards Isodityrosine, a component of biologically important cyclic peptides.

NISHIYAMA SHIGERU

CS Transactions (The 216th ECS Meeting)  21   91-95 2009

Research paper (conference, symposium, etc.), Joint Work, Accepted

Synthetic studies of mangostin derivatives with an inhibitory activity on PDGF-induced human aortic smooth cells proliferation.

NISHIYAMA SHIGERU

HETEROCYCLES 77 ( 2 ) 759-765 2009

Research paper (scientific journal), Joint Work, Accepted

A synthetic study on gymnastatins F and Q: the tandem Michael and aldol reaction approach.

NISHIYAMA SHIGERU

Tetrahedron Lett. 50   3191 – 3194 2009

Research paper (scientific journal), Joint Work, Accepted

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB.

NISHIYAMA SHIGERU

Bioorg. Med. Chem. Lett. 19   1726 – 1728 2009

Research paper (scientific journal), Joint Work, Accepted

Total synthesis of (±)-megistophylline I.

NISHIYAMA SHIGERU

Tetrahedron Lett. 50 ( 23 ) 2801 – 2804 2009

Research paper (scientific journal), Joint Work, Accepted

Efficient synthesis of (±)-parasitenone, a novel inhibitor of NF-κB.

NISHIYAMA SHIGERU

T Bioorg. Med. Chem. Lett. 19   5383-5386 2009

Research paper (scientific journal), Joint Work, Accepted

Palladium-catalyzed aromatic C-H halogenation with hydrogen halides by means of electrochemical oxidation.

NISHIYAMA SHIGERU

J. Am. Chem. Soc. 131 ( 32 ) 11310 – 11311 2009

Research paper (scientific journal), Joint Work, Accepted

隣接位に酸素官能基を有するビシナルジブロミドの脱離反応を利用した生物活性天然物の全合成研究.

NISHIYAMA SHIGERU

有機合成化学協会誌 66 ( 25 ) 139-147 2008.02

Research paper (scientific journal), Joint Work, Accepted

Electrochemical behavior of thallium ion in organic solvents and its application to organic synthesis.

NISHIYAMA SHIGERU

ECS Transactions (The 213th Meeting of the Electrochemical Society.)  13 ( 20 ) 7-12 2008

Research paper (conference, symposium, etc.), Joint Work, Accepted

Synthesis and antitumor activity of combretastatin D-4.

NISHIYAMA SHIGERU

HETEROCYCLES 75 ( 25 ) 291-296 2008

Research paper (scientific journal), Joint Work

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Combretastatin D-4 1 was synthesized using electrochemical
dimerization of phenols as the key step. Anodic oxidation of bromochloro-phenol 7 provided the corresponding diaryl ether 8. Manipulation of the two hydroxyl groups differenciated, provided the seco-acid, which on Mitsunobu reaction gave the target molecule. Its biological assay showed new potent inhibitory activity against cellular proliferation of human HT-29 colon carcinoma cells.

08010333052520080317173420PDF1.pdf

Oxidative access to quinolinone derivatives with simultaneous rearrangement of functional groups.

NISHIYAMA SHIGERU

Synlett  ( 1 ) 134-136 2008

Research paper (scientific journal), Joint Work, Accepted

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Hypervalent iodine-mediated oxidation of aromatic compounds carrying methoxyamide side chains provided the corresponding quinolinones. The reactive point was at the para position to electron-donating groups (such as a MeO group) in the aromaticring. Introduction of AcO or halogen groups to this position resultedin a cyclization, concomitant with rearrangement of the functional group.

08010333052620080317173720PDF1.pdf

Effects of aromatic substituents of electrochemically generated hypervalent iodine oxidant on oxidation reactions.

NISHIYAMA SHIGERU

HETEROCYCLES 75 ( 8 ) 1997 - 2003 2008

Research paper (scientific journal), Single Work

DBU Promoted elimination reactions of vicinal dibromoalkanes mediated by adjacent o-functional groups and applications to the synthesis of biologically active natural products.

NISHIYAMA SHIGERU

Synlett    3091-3105 2008

Research paper (scientific journal), Joint Work, Accepted

Synthesis of a spiroacetal moiety of antitumor antibiotic ossamycin by anodic oxidation.

NISHIYAMA SHIGERU

Tetrahedron 64   9495 - 9506 2008

Research paper (scientific journal), Joint Work, Accepted

よりクリーンな有機合成反応を目指して.

NISHIYAMA SHIGERU

化学 (化学同人)  62 ( 8 ) 66-67 2007.08

Research paper (scientific journal), Single Work, Accepted

新規生物活性物質を目指す有機電解合成

NISHIYAMA SHIGERU

化学と生物 (学会出版センター)  45 ( 3 ) 191-196 2007.03

Research paper (scientific journal), Single Work, Accepted

Asymmetric synthesis of the polyol subunit of the macrolide antibiotic, ossamycin: a unique approach utilizing stereochemical specificity.

N. Kutsumura and S. Nishiyama

Bull. Chem. Soc. Jpn. 79 ( 3 ) 468 － 478 2007.03

Research paper (scientific journal), Joint Work, Accepted

リグナン、ネオリグナン天然物化学ー植物編ー（山村庄亮、長谷川宏司編）

NISHIYAMA SHIGERU

天然物化学ー植物編ー（山村庄亮、長谷川宏司編） (アイピーシー出版部)     341-349 2007

Research paper (conference, symposium, etc.), Joint Work, Accepted

Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria.

A. Shimbashi and S. Nishiyama

Tetrahedron Lett. 48 ( 9 ) 1545-1548 2007

Research paper (scientific journal), Joint Work, Accepted

Synthesis of pinguisane-type sesquiterpenoids, acutifolone a, and pinguisenol, along with bisacutifolones through the Diels-Alder Dimerization reaction.

NISHIYAMA SHIGERU

Eur. J. Org. Chem.  ( 31 ) 5190-5197 2007

Research paper (scientific journal), Joint Work, Accepted

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The total synthesis of pinguisane-type sesquiterpenoids, acutifolone
A (1) and pinguisenol (2), has been achieved by
using the Mukaiyama aldol reaction as the key step. The
intermolecular Diels–Alder reaction of these monomeric natural
products successfully led to stereoselective dimerization,
leading to bisacutifolones A (3) and B (4). Theoretical calculations
revealed that the dimerization reaction proceeded
through the most stable transition state.

08010333052320080317172538PDF1.pdf

An efficient synthesis of propargylic ethers under the DBU conditions and its application to natural products synthesis.

T. Yokoyama, N. Kutsumura, T. Ohgiya, and S. Nishiyama

Bull. Chem. Soc. Jpn. 80 ( 37 ) 578-582 2006.03

Research paper (scientific journal), Single Work

Total synthesis, structural revision and biological evaluation of calafianin, a marine spiroisoxazoline from the sponge, Aplysina gerardogreeni.

T. Ogamino, R. Obata, H. Tomoda, and S. Nishiyama

Bull. Chem. Soc. Jpn. 79 ( 1 ) 134-139 2006.01

Research paper (scientific journal), Joint Work, Accepted

Oxidative cyclization of isodityrosine tripeptides with electrochemically generated thallium(III) ion.

T. Tanabe, R. Obata, and S. Nishiyama

HETEROCYCLES 69   113-118 2006

Research paper (scientific journal), Single Work, Accepted

Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative.

T. Ogamino, R. Obata and S. Nishiyama

Tetrahedron Lett. 47 ( 5 ) 727-731 2006

Research paper (scientific journal), Joint Work, Accepted

Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells activity.

T. Tanabe, T. Ogamino, Y. Shimizu, M. Imoto, and S. Nishiyama

Bioorg. Med. Chem. 14 ( 8 ) 2753 － 2762 2006

Research paper (scientific journal), Joint Work, Accepted

Synthesis and biological assessment of hemiacetal spiro derivatives towards development of efficient chemotherapeutic agent.

T. Ogamino, S. Ohnishi, Y. Ishikawa, R. Obata, and S. Nishiyama

STAM 7 ( 2 ) 175-183 2006

Research paper (scientific journal), Joint Work, Accepted

Synthesis of chiloscyphones and biological activities of their synthetic intermediates against methicillin-resistant Staphylococcus aureus (MRSA).

J. Shiina, R. Obata, H. Tomoda, and S. Nishiyama

Eur. J. Org. Chem.  ( 10 ) 2363-2370 2006

Research paper (scientific journal), Joint Work, Accepted

1,2-Dibromoalkanes into alkynes by elimination reaction under DBU conditions and its application to total synthesis of sapinofuranone B.

N. Kutsumura, T. Yokoyama, T. Ohgiya, and S. Nishiyama

Tetrahedron Lett. 47 ( 25 ) 4133-4136 2006

Research paper (scientific journal), Single Work, Accepted

Solid-phase synthesis and biological activities of biphenyl ether-containing cyclic oligopeptides.

K. Nakamura, R. Obata, and S. Nishiyama

Peptide Science 2005, The Japanese peptide Society    127-130 2006

Research paper (scientific journal), Joint Work, Accepted

Oxidation of mangostins, the naturally occurring xanthone derivatives carrying diverse biological activities.

Y. Nishihama, Y. Amano, T. Ogamino, and S. Nishiyama

Electrochemistry 74 ( 8 ) 609-611 2006

Research paper (scientific journal), Joint Work, Accepted

Synthetic studies of N-demethylossamine and elaboration of its glycosylation.

N. Kutsumura and S. Nishiyama

J. Carbohydr. Chem. 25   377-385 2006

Research paper (scientific journal), Joint Work, Accepted

Oxidative synthesis of azacyclic derivatives through the nitrenium ion: application of a hypervalent iodine species electrochemically generated from iodobenzene.

Y. Amano and S. Nishiyama

Tetrahedron Lett. 47 ( 37 ) 6505-6507 2006

Research paper (scientific journal), Joint Work, Accepted

Total synthesis of (+)-tanikolide, using regioselective elimination of a vicinal dibromoalkane.

T. Ohgiya, K. Nakamura, and S. Nishiyama,

Bull. Chem. Soc. Jpn. 78 ( 8 ) 1549-1554 2005.08

Research paper (scientific journal), Joint Work, Accepted

フェニルピルビン酸オキシムを基本骨格とする海洋生物由来の生物活性物質の化学.

NISHIYAMA SHIGERU

有機合成化学協会誌 63 ( 6 ) 583-593 2005.06

Research paper (scientific journal), Single Work

フェニルピルビン酸オキシムを基本骨格とする海洋生物由来の生物活性物質の化学.

NISHIYAMA SHIGERU

有機合成化学協会誌 63 ( 6 ) 583-593 2005

Research paper (scientific journal), Joint Work, Accepted

The first total synthesis of acutifolone A, a pinguisane-type sesquiterpenoid isolated from the Japanese liverwort Porella acutifolia subsp. tosana.

J. Shiina and S. Nishiyama

Tetrahedron Lett. 46 ( 45 ) 7683-7686 2005

Research paper (scientific journal), Joint Work, Accepted

Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages.

R. Obata, T. Ohshiro, H. Tomoda, and S. Nishiyama

Bioorg. Med. Chem. Lett. 15 ( 19 ) 4189-4191 2005

Research paper (scientific journal), Joint Work, Accepted

Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity.

A. Shimbashi, A. Tsuchiya, M. Imoto, and S. Nishiyama

Bioorg. Med. Chem. Lett. 15 ( 1 ) 61-65 2005

Research paper (scientific journal), Joint Work, Accepted

Synthesis and structural revision of calafianin, a member of the spiroisoxazole family isolated from the marine sponge, Aplysina gerardogreeni.

NISHIYAMA SHIGERU

Tetrahedron Lett. 46 ( 7 ) 1083-1086 2005

Research paper (scientific journal), Joint Work, Accepted

Asymmetric synthesis of the polyol subunit of the macrolide antibiotic, ossamycin.

N. Kutsumura and S. Nishiyama

Tetrahedron Lett. 46 ( 34 ) 5707-5709 2005

Research paper (scientific journal), Joint Work, Accepted

Synthesis of chroman derivatives by the ring expansion reaction of spirodienones, and an assessment of their plant growth inhibition.

NISHIYAMA SHIGERU

Bull. Chem. Soc. Jpn. 77 ( 12 ) 2257 - 2263 2004.12

Research paper (scientific journal), Joint Work, Accepted

Conversion of 3-O-Substituted 1,2-dibromoalkanes into 2-bromo-1-alkenes by the selective elimination: its application to total synthesis of 12-oxigenated tremetones

T. Ohgiya and S. Nishiyama

Chem. Lett. 2004 ( 9 ) 1084 - 1085 2004.09

Research paper (scientific journal), Joint Work, Accepted

A new approach to the bicyclo[4.3.0] ring system of natural products from the liverwort; total synthesis of (±)-chiloscyphone and (±)-isochiloscyphone.

NISHIYAMA SHIGERU

Tetrahedron Lett. 45 ( 49 ) 9033-9036 2004

Research paper (scientific journal), Joint Work, Accepted

Synthesis of the BCD ring system of azaspiracid: construction of the trispiroring structure by the thioether approach.

Y. Ishikawa and S. Nishiyama

Tetrahedron Lett. 45 ( 2 ) 351 - 354 2004

Research paper (scientific journal), Joint Work, Accepted

Synthesis of (±)-pyranonaphthoquinone derivatives, a Cdc25A phosphatase inhibitor.

A. Shimbashi, Y. Ishikawa, and S. Nishiyama

Tetrahedron Lett. 45 ( 5 ) 939 - 941 2004

Research paper (scientific journal), Joint Work, Accepted

Synthetic studies on azaspiracid, a novel shellfish poison: attempts to construct the ABCD ring system

Y. Ishikawa and S. Nishiyama

HETEROCYCLES 63 ( 3 ) 539 － 565 2004

Research paper (scientific journal), Joint Work, Accepted

Synthesis of the ABCD ring system of azaspiracid, a marine poison from Mytilus Edulis

Y. Ishikawa and S. Nishiyama

HETEROCYCLES 63 ( 4 ) 885 － 893 2004

Research paper (scientific journal), Joint Work, Accepted

A total synthesis of verbenachalcone, a bioactive diaryl ether from Verbena littoralis

T. Tanabe, F. Doi, T. Ogamino and S. Nishiyama

Tetrahedron Lett. 45 ( 17 ) 3477 - 3480 2004

Research paper (scientific journal), Joint Work, Accepted

The first total synthesis and absolute stereochemistry of plakortone G from the Jamaican sponge Plakortis sp.

S. Kowashi, T. Ogamino, J. Kamei, Y. Ishikawa and S. Nishiyama

Tetrahedron Lett. 45 ( 22 ) 4393-4396 2004

Research paper (scientific journal), Joint Work, Accepted

Total synthesis of eurypamides, marine cyclic-isodityrosines from the Palauan sponge Microciona eurypa

M. Ito, M. Yamanaka, N. Kutsumura and S. Nishiyama

Tetrahedron 60 ( 26 ) 5623-5634 2004

Research paper (scientific journal), Joint Work, Accepted

Plant-growth inhibitory activity of heliannuol derivatives

F. Doi, T. Ohara, T. Ogamino, T. Sugai, K. Higashinakasu, K. Yamada, H. Shigemori, K. Hasegawa, and Shigeru Nishiyama

Phytochem. 65 ( 10 ) 1405-1411 2004

Research paper (scientific journal), Joint Work, Accepted

The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products

D. Iijima, D. Tanaka, M. Hamada, T. Ogamino, Y. Ishikawa, and S. Nishiyama,

Tetrahedron Lett. 45 ( 28 ) 5469-5471 2004

Research paper (scientific journal), Joint Work, Accepted

Electrochemical bromination of germacrene D

T. Ogamino, K. Mori, S. Yamamura, and S. Nishiyama

ELECTROCHIMICA ACTA 49 ( 27 ) 4865-4869 2004

Research paper (scientific journal), Joint Work, Accepted

A simple deprotection of triflate esters of phenol derivatives

T. Ohgiya and S. Nishiyama

Tetrahedron Lett. 45 ( 33 ) 6317 - 6320 2004

Research paper (scientific journal), Joint Work, Accepted

Synthesis of (-)-tuliparin B utilizing 2-bromo-1-alkenes conveniently synthesized from the 3-o-substituted 1,2-dibromoalkane system by regioselective elimination

T. Ohgiya and S. Nishiyama

HETREROCYCLES 63 ( 10 ) 2349 - 2354 2004

Research paper (scientific journal), Joint Work, Accepted

Total Synthesis of (+)-tanikolide, a toxic and antifungal δ-lactone, utilizing bromoalkene intermediates conveniently synthesized from vicinal dibromoalkane by regioselective elimination.

NISHIYAMA SHIGERU

Tetrahedron Lett. 45 ( 45 ) 8273-8275 2004

Research paper (scientific journal), Joint Work, Accepted

Synthetic studies on bioactive natural products employing electrochemical methodology, synthesis of heliannuol E.

F. Doi, T. Ogamino, T. Sugai, and S. Nishiyama

Proceedings - Electrochemical Society (2003), 2003-12(Mechanistic and Synthetic Aspects of Organic and Biological Electrochemistry) (Electrochemical Society)  2003 ( 12 ) 117-120 2003.12

Research paper (conference, symposium, etc.), Joint Work

　View Summary

Synthetic studies on heliannuol E, an allelochemical of sunflower, was synthesized by employing electroorganic chemistry.

Synthetic studies on bioactive natural products employing electrochemical methodology, synthesis of heliannuol E.

F. Doi, T. Ogamino, T. Sugai, S. Nishiyama

The 203rd Meeting of The Electrochemical Society  2003.04

Joint Work, Accepted

　View Summary

有機電極反応を活用した天然物合成に関する研究について、ヒマワリのアレロパシー物質ヘリアヌオールを中心に発表した。

A new ring-opening access to aeroplysinin-1, a secondary metabolite of Verongia aerophoba.

T. Ogamino and S. Nishiyama

Tetrahedron 59 ( 47 ) 9419 - 9423 2003

Research paper (scientific journal), Joint Work

Synthesis of bioactive sesquiterpene heliannuol e involving a ring-expansion reaction of spirodienones

F. Doi, T. Ogamino, T. Sugai, and S. Nishiyama

Synlett    411　-　413 2003

Research paper (scientific journal), Joint Work, Accepted

　View Summary

ヒマワリのアレロパシー物質であるヘリアヌオールEの有機電極反応と選択的転位反応を活用した新規合成法を報告した。３ページ

Intramolecular Diels-Alder reaction leading to tricyclic derivatives as intermediates of natural products synthesis

J. Shiina and S. Nishiyama

Tetrahedron 59 ( 32 ) 6039 - 6044 2003

Research paper (scientific journal), Joint Work, Accepted

　View Summary

三環性化合物構築のための分子内Deals-Alder反応について検討した

Biological activities of a-mangostin derivatives against acidic sphingomyelinase

M. Hamada, K. Iikubo, Y. Ishikawa, A. Ikeda, K. Umezawa, and S. Nishiyama

Bioorg. Med. Chem. Lett. 13 ( 19 ) 3151 - 3153 2003

Research paper (scientific journal), Joint Work, Accepted

Electrochemical synthesis of spiroisoxazole derivatives and its application to natural products

T. Ogamino, Y. Ishikawa, and S. Nishiyama

HETEROCYCLES 61 2003

Research paper (scientific journal), Joint Work, Accepted

Synthesis and Structural Revision of Eurypamides Isolated from the Palauan Sponge Microciona eurypa

M. Ito, M. Yamanaka, N. Kutsumura, and S. Nishiyama

Tetrahedron Lett. 44 2003

Research paper (scientific journal), Joint Work, Accepted

Enantioselective synthesis of heliannuol E; structural consideration of natural molecule.

NISHIYAMA SHIGERU

Tetrahedron Lett., 44 ( 26 ) 4877 - 4880 2003

Research paper (scientific journal), Joint Work, Accepted

　View Summary

光学活性体として、ヘリアヌオールEを全合成し、従来報告されていた構造の誤りを訂正した。

α－マンゴスチンとその関連物質の合成と生物活性

飯久保一彦、石川裕一、濱田基子、田中大輔、池田　彩、梅沢一夫、西山　繁

第４４回天然有機化合物討論会  2002.10

Research paper (scientific journal), Joint Work, Accepted

生物活性セスキテルペンheliannuol E の合成研究

土居史尚、小神野孝尚、須貝　威、西山　繁

２００２年電気化学秋季大会  2002.09

Research paper (conference, symposium, etc.), Single Work, Accepted

Reactivity of naphthol towards nucleophiles in anodic oxidation

. H. R. El-Seedi, S. Yamamura, and S. Nishiyama

Tetrahedron 58   7485 - 7489 2002

Research paper (scientific journal), Single Work, Accepted

　View Summary

4-methoxy-1-naphtholの酸化反応を詳細に検討した

Anodic oxidation of phenols towards the synthesis of bioactive natural products.

S. Yamamura and S. Nishiyama

Synlett    533 - 543 2002

Joint Work

　View Summary

フェノール陽極酸化を用いる天然物合成。(11頁)

The first direct synthesis of a-mangostin, a potent inhibitor of the acidic sphingomyelinase

西山 繁

Tetrahewdron Lett. 43 ( 2 ) 291-293 2002

Research paper (scientific journal), Joint Work, Accepted

　View Summary

α-マンゴスチンの合成。(3頁)

Synthetic studies on ceratospongamides, cyclic heptapeptides containing thiazole and oxazoline units: total synthesis of cis,cis-ceratospongamide.

N. Kutsumura, N. U. Sata, and S. Nishiyama

Bull. Chem. Soc. Jpn. 75   847 - 850 2002

Research paper (scientific journal), Joint Work, Accepted

　View Summary

海産物由来のcis,cis-セラトスポンガミドを合成した。

Anodic Oxidation of 4-Methoxy-1-naphthol.

H. R. El-Seedi, S. Yamamura, and S. Nishiyama

Tetrahedron Lett. 43   3301 - 3304 2002

Research paper (scientific journal), Joint Work, Accepted

　View Summary

有機電極反応によりナフトールの酸化反応を行った。

多剤耐性癌克服活性を有するデプシペプチド海洋天然物ハパロシンの化学と生物活性

西山 繁

有機合成化学協会誌  2001.10

Single Work

　View Summary

ハパロシンの合成総説(10頁)

Synthesis of a cyclic diaryl ether derivative under solid-phase conditions.

K. Nakamura, H. Nishiya, and S. Nishiyama

Tetrahedron Lett. 42 2001

Joint Work

　View Summary

環状ジアリールエーテルの固相合成。(3頁)

Synthesis and biological activities of haoalosin derivatives with modification at the C12 position.

N.　Kashihara,　S. To-e, K. Nakamura, K.Umezawa, S. Yamamura, and S.Nishiyama

Bioorg.Med.Chem.Lett.,  2000.01

Joint Work

　View Summary

C１２位を修飾したハパロシン誘導体を合成し、その活性を評価した。(3頁)

Phenolic oxidation of halogenated phenols.

New Directions in Organic Electrochemistry, (A. J. Fry and Y. Matsumura Ed.), THE ELECTROCHEMICAL SOCIETY, INC, Proceedings Vol 2000-15   17-20 2000

Joint Work

　View Summary

K. Mori, M. Takahashi, S. Yamamura, and S. Nishiyama

N-Carbamylamino alcohols as the precursors of oxazolidinones via nitrosation-deamination reaction

M. Suzuki, T. Yamazaki. H. Ohta, K. Shima, K. Ohi, S. Nishiyama. And T.sugai

SYNLETT  2000

Research paper (scientific journal), Joint Work, Accepted

　View Summary

N-カルバモイルアミノアルコールよりオキサゾリジノンを効率よく合成し、さらにそのホスホラン誘導体を合成した。(4頁)

(-)-(3S)-4-(2-{[4,4-Dimethozy-6-(benzyloxymethy])perhydropyran-2-yl]methy]}-1,3-dithian-2-yl)-4-meth yl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol

H. Hosomi, S. Ohba, K. Ohmori, T. Obitsu, Y. Ogawa, Y. Ishikawa, S. Yamamura, S. Nishiyama

Acta Cryst C    e140-e141 2000

Joint Work

　View Summary

抗腫瘍性天然物ブリオスタチンの合成において、表題化合物のX線結晶解析を行った。(2頁)

(+)-3-{(4S,5S)-5-[1,1-dimethyl-2-(phenylthio)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}prop-2-yn-1-ol

H. Hosomi, S. Ohba, K. Ohmori, T. Obitsu, Y.Ogawa, Y. Ishikawa, S.Yamamura, S. Nishiyama

Acta Cryst.C56  2000

Joint Work

　View Summary

抗腫瘍性天然物ブリオスタチンの合成において、表題化合物のX線結晶解析を行った。(2頁)

Total synthesis of bryostatin 3.

Angew. Chem. Int. Ed.  2000

Joint Work

　View Summary

K. Ohmori, Y. Ogawa, T. Obitsu, Y. Ishikawa, S. Nishiyama, and S. Yamamura(5頁)

Phenolic oxidation of o, o'-dihalogenated phenols.

M,Takahashi,H.Konishi,S.Iida,K,Nakamura,S.Yamamura,and S.Nishiyama

Tetrahedron  1999.04

Joint Work

　View Summary

ジハロゲン化フェノール類の陽極酸化反応の反応性を検討した。(8頁)

An asatone-type neolignan and its photocage product.

R. Yoshihara, K.Mori, S.Nishiyama, S.Yamamura, H.hosomi, S.Ohba, and Y.Ito

Acra Cryst.C  1999

Joint Work

　View Summary

アサトン型ネオリグナンの光反応によって生成する生成物の構造について研究した。(4頁)

Synthetic study on top-half(C14-C25) fragment of amphidinolide B, a 26-membered macrolide.

K.Ohi and S.Nishiyama

SYNLETT  1999

Joint Work

　View Summary

アンフィジノライドBの上半球(C14-C25)位部分を合成した。(3頁)

Construction of the diene moiety (C9-C18) of amphidinolideB, a 26-membered macrolide.

K.Ohi and S.Nishiyama

SYNLETT  1999

Joint Work

　View Summary

アンフィジノライドBのC9-C18位部位を構成するジエンの構築報を開発した。(2頁)

Synthesis of the C17-C27 fragment of bryostatin 3

Tetrahedron Lett.  1998.10

Joint Work

　View Summary

ブリオスタチン３の部分構造の合成(4頁）

Synthetic study on a 26-membered macrolide, amphidinolide B: synthesis of the C1-C13 fragment

Bull. Chem. Soc. Jpn.  1998.10

Joint Work

　View Summary

アンフィジノライドBの部分構造の合成（8頁）

Synthesis of [(2’S,3’S)-bis(hydroxymethyl)pyrrolidin-1-yl]purine and pyrimidine nucleosides as potential antiviral agents

Biomed. Chem. Lett.  1998

Joint Work

　View Summary

抗ウイルス性ヌクレオシド化合物の合成（2頁）

Synthetic approaches towards　laulimalide: synthesis of the C12-C29　fragment.

清水敦司、西山　繁

SYN LETT  1998

Joint Work

　View Summary

ラウリマライドのＣ12-Ｃ29位部分を合成した。(2頁)

Reactivity of o,o'-dihalogenated phenols　in anodic oxidations.

西山　繁、小西宏典、飯田　哲、山村庄亮

Novel Trends in Electro-organic Synthesis, (S. Torii Ed.), Springer-Verlag  1998

Joint Work

　View Summary

ジハロゲン化フェノールの電解酸化における反応性について考察した。（２頁）

Synthesis of [2'S,3'S)-bis(hydroxymethyl)pyrrolidin-1-yl]purine and　pyrimidine nucleosides as potential antiviral　agents.

大橋岳人、西山　繁、山村庄亮、加藤國基

Bioorg. Med. Chem. Lett.  1998

Joint Work

　View Summary

ヌクレオシド類似体を合成し、その活性を評価した。（２頁）

Synthetic study on a 26-membered　macrolide, amphidinolide B: synthesis of　the C1-C13 fragment.

大井克秀、島　恭子、浜田こず枝、斉藤義男、山田直樹、大場　茂、西山　繁

Bull. Chem. Soc. Jpn.  1998

Joint Work

　View Summary

アンフィジノリドＢのＣ1-Ｃ13位部分を合成した。（８頁）

Synthesis of the C17-C27 fragment of　bryostatin 3

小櫃哲夫、大森　建、小川泰之、細見博之、大場　茂、西山　繁、山村庄亮

Tetrahedron Lett.  1998

Joint Work

　View Summary

ブリオスタチン３のＣ17-Ｃ27位部分を合成した。（４頁）

ハロゲンを鍵元素とする有機電解合成

淵上寿雄, 西山繁

電気化学および工業物理化学  1997

Research paper (scientific journal), Joint Work

　View Summary

ハロゲンを鍵元素とする有機電解合成について解説した。（５頁）

Synthesis of the C1-C16 fragment of the　marine toxin, laulimalide.

清水敦司、西山　繁

Tetrahedron Lett.  1997

Joint Work

　View Summary

ラウリマライドのC1-C16 部分の効率的な合成について報告した。（４頁）

Synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-α-L-threofuranosyl]adenine　and its 4'-thio analog as potential antiviral　agents.

菊池淑子、倉田弘子、西山　繁、山村庄亮、加藤國基

Bioorg. Med. Chem. Lett.  1997

Joint Work

　View Summary

抗ウイルス剤としてヌクレオシド類似体を合成した。（４頁）

Synthetic studies on polypropionate-derived 4-pyrone-containing marine natural　 products.

西山　繁、山村庄亮

Bull. Chem. Soc. Jpn.  1997

Joint Work

　View Summary

4-ピロン類の新規合成法と関連天然物の合成を総括的に報告した。（１３頁）

Chemical study on hapalosin, a cyclic　depsipeptide possessing multidrug　resistance reversing activities: synthesis,　

奥野利明、大森　建 、西山　繁、山村庄亮、中村健介、K. N. Hauk、岡本一也

Tetrahedron  1996

Joint Work

　View Summary

多剤耐性癌ハパロシンの合成、立体化学、生理活性に（１２頁）

Interaction between cell wall model of　vancomycin resistant strain and agluco-vancomycin synthetic analogs.

中村和彦、西山　繁、山村庄亮

Tetrahedron Lett.  1996

Joint Work

　View Summary

バンコマイシン耐性菌とアグルコバンコマイシン類縁体の相互作用を検討した。（２頁）

Synthetic approach towards the 2,8-dioxabicyclo[3.2.1]octane core system of　zaragozic acids (squalestatins), potent inhibitors of squalene synthase.

清水敦司、大森　建、大場　茂、西山　繁、山村庄亮

Carbohydr. Lett.  1996

Joint Work

　View Summary

糖誘導体を用いて、ザラゴジン酸の二環性骨格を合成した。（８頁）

Total synthesis of phenoxan and a related　pyrone derivative.

石橋泰治、大場　茂、西山　繁、山村庄亮

Tetrahedron Lett.  1996

Joint Work

　View Summary

抗ウイルス性ピロン誘導体フェノキサンを合成した。（４頁）

Synthetic study on hapalosin, a cyclic　depsipeptide possessing multidrug　resistance reversing activities.

大森　建、奥野利明、西山　繁、山村庄亮

Tetrahedron Lett.  1996

Joint Work

　View Summary

多剤耐性癌克服活性を有する海洋天然物ハパロシンを合成し、構造の特性を考察した。（４頁）

TTN Oxidation of mixed halogenated　phenols: synthesis of vancomycin model　diaryl ether possessing a chlorine atom.

小西宏典、奥野利明、西山　繁、山村庄亮、子安克也、寺田幸正

Tetrahedron Lett.  1996

Joint Work

　View Summary

バンコマイシンに特有のモノ塩素化ジチロシンの合成法を開発した。（４頁）

Anodic oxidation of N-alkylanilines

西山　繁、飯田陽子、日野志朗、山村庄亮

Electrochimica Acta  1996

Joint Work

　View Summary

Ｎ-アルキルアニリンの電解酸化反応における反応機構を考察した。（７頁）

スクアレン合成酵素阻害剤の合成

西山　繁

化学  1995

Research paper (scientific journal), Single Work

　View Summary

スクアレン合成阻害剤ザラゴジン酸の全合成に関する解説（２頁）

Interaction between bacterial cell wall　model and aglucovancomycin or its　synthetic analogs.

中村和彦、西山　繁、山村庄亮

Tetrahedron Lett.  1995

Joint Work

　View Summary

アグルコバンコマイシン類縁体とバクテリア細胞壁モデルとの相互作用を理論計算を用いて考察した。（４頁）

Absolute configuration of (+)- aureothin,　a toxic metabolite possessing γ-pyrone unit.

石橋泰治、大場　茂、西山　繁、山村庄亮

Bull. Chem. Soc. Jpn.  1995

Joint Work

　View Summary

オーレオシンの絶対構造を確定した。（７頁）

Synthetic studies on fully substituted γ-pyrone-containing natural products: total　synthesis and structural revision of　onchitriol I.

有本博一、奥村保明、西山　繁、山村庄亮

Tetrahedron Lett.  1995

Joint Work

　View Summary

オンキトリオールＩの全合成を行い、提出されていた構造を訂正した。（２頁）

Electrochemical approach to isodityrosine　and related natural products.

西山　繁、金　文煥、山村庄亮

Novel Trends in Electro-organic Synthesis, (S. Torii Ed.)  1995

Joint Work

　View Summary

イソジチロシンの電解酸化反応について報告した。（２頁）

Synthetic studies on bryostatins, potent　antineoplastic agents: synthesis of the　C17-C27 fragment of C20　deoxybryostatins.

大森　建、鈴木孝之、西山　繁、山村庄亮

Tetrahedron Lett.  1995

Joint Work

　View Summary

Ｃ-２０位デオキシブリオスタチン類の下半球骨格を合成した。（４頁）

Synthetic studies on bryostatins, potent　antineoplastic agents: synthesis of the　C17-C27 fragment of C20 oxygenated　bryostatins.

大森　建、西山　繁、山村庄亮

Tetrahedron Lett.  1995

Joint Work

　View Summary

Ｃ-２０酸素化ブリオスタチン類の下半球骨格を合成した。（４頁）

Synthetic studies on vancomycin:　synthesis of seco-agluco- vancomycins.

中村和彦、西山　繁、山村庄亮

Tetrahedron Lett.  1995

Joint Work

　View Summary

セコアグルコバンコマイシン類を合成した。（４頁）

Conformational analysis of agluco-vancomycin analogs.

中村和彦、西山　繁、山村庄亮

Tetrahedron Lett.  1995

Joint Work

　View Summary

セコアグルコバンコマイシン類の立体化学について解析

Synthetic studies on fully substitutd γ-pyrone-containing natural products: the　first toltal synthesis of onchitriol II.

有本博一、西山　繁、山村庄亮

Tetrahedron Lett.  1994

Joint Work

　View Summary

オンキトリオールＩＩの最初の全合成を達成した。（４頁）

Total syntheses of makaluvamines A, B, C　and D, metabolites of the Fijian sponge　Zyzza cf. marsailis exhibiting inhibitory　activities against topoisomerase II.

伊沢孝夫、西山　繁、山村庄亮

Tetrahedron Lett.  1994

Joint Work

　View Summary

トポイソメラーゼＩＩ阻害活性を有するマカルバミン類の合成を行った。（２頁）

Synthetic studies on tetrahydropyrrolo-quinoline-containing natural products:　syntheses of discorhabdin C, batzelline C　and isobatzelline C

陶　雪良、程　傑飛、西山　繁、山村庄亮

Tetrahedron  1994

Joint Work

　View Summary

デスコハブディンＣ、バゼリンおよびイソバゼリンＣの合成の詳報を報告した。（１２頁）

Chemical properties of β-triketones: reexamination of Albizati's tandem aldol　process.

有本博一、大場　茂、西山　繁、山村庄亮

Tetrahedron Lett.  1994

Joint Work

　View Summary

トリケトン類について従来報告されていたピロン環形成反応の誤りを訂正した。（４頁）

Structural revision of griseulin, a bioactive　pyrone possessing a nitrophenyl subunit.

西山　繁、山村庄亮

Chem. Lett.  1994

Joint Work

　View Summary

ピロン性天然物グリセウリンの構造を訂正した。

Synthesis and antiviral activity of　alkylphosphonic acid derivatives of　oxetanocin-A.

石橋泰治、西山　繁、山村庄亮

Biomed. Chem. Lett.  1994

Joint Work

　View Summary

C-P 結合を有するオキセタノシン誘導体を合成し、活性を評価した。（２頁）

Synthesis and antiviral evaluation of　 [(2'S,3'S)-bis(hydroxymethyl)azetidin-1-yl]pyrimidine nucleosides: analogs of　oxetanocin-A.

細野文生、西山　繁、山村庄亮、伊沢孝夫、加藤國基

Tetrahedron Lett.  1994

Joint Work

　View Summary

アゼチジンヌクレオシドを合成し、活性を評価した。（４頁）

Syntheses of isodityrosine, dityrosine and　related compounds by phenolic oxidation　of tyrosine and phenylglycine derivatives　using an electrochemical method.

西山　繁、金　文煥、山村庄亮

Tetrahedron Lett.  1994

Joint Work

　View Summary

電極酸化によりイソジチロシン、ジチロシンおよび関連化合物を合成した。（４頁）

Enantiospecific synthesis of [(2'S,3'S)-bis(hydroxymethyl)azetizin-1-yl]pyrimidine　nucleosides as potential antiviral agents.

細野文生、西山　繁、山村庄亮、伊沢孝夫、加藤國基、寺田幸正

Tetrahedron  1994

Joint Work

　View Summary

アゼチジンヌクレオシド合成の詳報を報告した。（１２頁）

Total syntheses of makaluvamines A, B, C,　D and E, cytotoxic pyrroloiminoquinone　alkaloids isolated from marine sponge　bearing inhibitory activities against　topoisomerase II.

伊沢孝夫、西山　繁、山村庄亮

Tetrahedron  1994

Joint Work

　View Summary

マカルバミン類を合成し、関連物質のトポイソメラーゼＩＩ活性を調べた。（８頁）

The structures of bioactive cyclo-　depsipeptides, beauveriolides I and II,　metabolites of entomopathogenic fungi　Beauveria sp..

望月恵子、大森　建、田村晴美、志津理芳一、西山　繁、三義英一、山村庄亮

Bull. Chem. Soc. Jpn.  1993

Joint Work

　View Summary

天敵糸状菌の産生するビューベリオリドＩおよびＩＩの構造を決定した。（６頁）

Synthetic studies on bryostatins,　antineoplastic metabolites: convergent　synthesis of the C1-C16 fragment shared by　all of the bryostatin family.

大森　建、鈴木孝之、宮沢和之、西山　繁、山村庄亮

Tetrahedron Lett.  1993

Joint Work

　View Summary

全てのブリオスタチンに共通する上半球を合成した。（４頁）

Synthetic studies on fully substituted γ-pyrone-containing natural products: the　absolute configurations of ilikonapyrone　and peroniatriols I and II.

有本博一、程　傑飛、西山　繁、山村庄亮

Tetrahedron Lett.  1993

Joint Work

　View Summary

含ピロン天然物イリコナピロン、ペロニアトリオールＩおよびＩＩの絶対構造を合成的に確定した。（４頁）

Efficient synthesis of the optically active　cyclopentane derivative, a versatile　intermediate toward the Euphorbia　diterpenes.

松浦智夫、西山　繁、山村庄亮

Chem. Lett.  1993

Joint Work

　View Summary

ユーホルビアジテルペン類合成のためのシクロペンタン誘導体の効率的合成を報告した。（２頁）

Synthesis of (t-2-benzyloxymethyl-r-1-methoxycarbonyl)tetrahydrofuran from an　arabino-lactone triflate with K2CO3-MeOH.

伊沢孝夫、中山久美子、西山　繁、山村庄亮、加藤國基、滝田智久

 1992

Joint Work

　View Summary

糖ラクトンの異常反応について報告した。（２頁）

Total synthesis of (+)-isoaureothin: Determination of the absolute configurations　of aureothin , isoaureothin and spectinabilin.

石橋泰治、西山　繁、志津里芳一、山村庄亮

Tetrahedron Lett.  1992

Joint Work

　View Summary

(+)-イソオーレオシンを全合成し、この結果を基にオーレオシンとスペクチナビリンの絶対構造を予測した。（４頁）

A facile enantioselective synthesis of　 (1R,2R,3S)-1-amino-2,3-bishydroxy-methylcyclobutane derivatives, a key　synthetic intermediate of carbocyclic　oxetanocins.

伊沢孝夫、荻野悦夫、西山　繁、山村庄亮、加藤國基、滝田智久

Tetrahedron  1992

Joint Work

　View Summary

炭素環オキセタノシン合成の中間体である光学活性シクロブタン誘導体の簡便な合成法を報告した。（８頁）

Oxetanocin - oxetanose chemistry:　Lewis acid promoted glycosidations of the　D-erythrooxetanose derivatives

西山　繁、扇谷忠明、山村庄亮、加藤國基、滝田智久

Nucleosides & Nucleotides  1992

Joint Work

　View Summary

エリスロオキセタノースのグリコシル化について反応性を検討した。（２０頁）

Syntheses of trans- and cis-3- methoxy-4-methylthio-2-piperidinethiones previously　proposed structures for raphanusanins, structural revision, and biological activities　of their congeners.

西山　繁、稲垣富生、山村庄亮、長谷川宏司、水谷純也、迫田理子

Bull. Chem. Soc. Jpn.  1992

Joint Work

　View Summary

植物生長調節物質ラファヌサニン関連物質の合成とそれらの活性について報告した。（４頁）

Synthesis of carbocyclic nucleosides: Synthesis of (+/-)-2,2-bis-(hydroxymethyl)　cyclopropyl nucleosides.

伊沢孝夫、西山　繁、山村庄亮、加藤國基、滝田智久

J. Chem. Soc. Perkin Trans. I  1992

Joint Work

　View Summary

糖部分にシクロプロパンを有するヌクレオシド類縁体を合成した。（７頁）

5 M LiClO_4_ - エーテルを用いる Diels Alder 反応.

西山　繁

化学と工業  1991

Research paper (scientific journal), Single Work

　View Summary

有機合成反応について解説（2頁）

Syntheses of 2,2-bishydroxymethylcyclopropyl adenine and uracil, novel　carbocyclic nucleosides.

西山　繁、植木信哉、渡辺達也、山村庄亮、加藤國基、滝田智久

Tetrahedron Lett.  1991

Joint Work

　View Summary

糖部分にシクロプロパンを有する異常ヌクレオシドを合成した。（２頁）

Synthetic studies on oxetanocin analogs: Synthesis of 2-deoxy-2-hydroxymethyl-β-D-erythrooxetanosyl maleimide.

渡辺達也、西山　繁、山村庄亮、加藤國基、永井雅史、滝田智久

Tetrahedron Lett.  1991

Joint Work

　View Summary

異常ヌクレオシドオキセタノシルマレイミドを合成した。（２頁）

Synthetic studies on novel sulfur-　containing alkaloids, prianosins　and discorhabdins: Total synthesis of　discorhabdin C.

西山　繁、程　傑飛、陶　雪良、山村庄亮

Tetrahedron Lett.  1991

Joint Work

　View Summary

含硫黄アルカロイドデスコハブディンＣを全合成した。（４頁）

Total syntheses of batzelline C and　isobatzelline C, the novel pyrroloquinoline　alkaloids isolated from the marine sponge　Batzella sp.

陶　雪良、西山　繁、山村庄亮

Chem. Lett.  1991

Joint Work

　View Summary

海産ピロロキノリン型アルカロイド、バゼリンおよびイソバゼリンＣを全合成した。（２頁）

Syntheses of trans- and cis-3-methoxy-4-methylthio-2-piperidinethiones previously　proposed for raphanusanins; correct　structures of raphanusanins

西山　繁、山村庄亮、長谷川宏司、迫田理子、原田勝正

Tetrahedron Lett.  1991

Joint Work

　View Summary

植物生長調節物質ラファヌサニン関連物質を合成し、提唱されていたラファヌサニンの構造を訂正した。（４頁）

Revision of the structure of raphanusanins,　phototropism- regulating substances of　 radish hypocotyls.

原田宣之、萩原久弘、小野　宏、宇田　尚、大場　茂、久保田真理、西山　繁、山村庄亮、長谷川宏司、迫田理子

Tetrahedron Lett.  1991

Joint Work

　View Summary

植物生長調節物質ラファヌサニンの構造を訂正した。（４頁）

Synthesis of unusual nucleosides and　evaluations of their biological properties.

渡辺達也、植木信哉、信国高広、西山　繁、山村庄亮、加藤國基、永井雅史、滝田智久

Nucleic Acids Res. Symp. Ser., Oxford University Press  1990

Joint Work

　View Summary

異常ヌクレオシドの合成と生理活性について報告した。（２頁）

A facile and practical synthesis of the　derivatives of 1-O-acetyl-2-deoxy-2-hydroxymethyl-D-erythrooxetanose, a key　sugar moiety for the synthesis of　oxetanosyl-N-glycoside.

永井雅史、加藤國基、滝田智久、西山　繁、山村庄亮

Tetrahedron Lett.  1990

Joint Work

　View Summary

オキセタノシン型ヌクレオシド合成の鍵中間体となるオキセタノース誘導体の簡便な合成法を報告した。（２頁）

Synthetic studies on new sugar oxetanose: synthesis of D-erythro-oxetanose and its　reaction with silylated adenine derivative.

西山　繁、扇谷忠明、山村庄亮、加藤國基、永井雅史、滝田智久

Tetrahedron Lett.  1990

Joint Work

　View Summary

エリスロオキセタノースの合成と、ヌクレオシド塩基との反応性について報告した。（４頁）

Synthesis of optically active hexa-hydrofuro[2,3-b]furan, a non-chromophore moiety of asteltoxin.

西山　繁、金井宏樹、山村庄亮

Bull. Chem. Soc. Jpn.  1990

Joint Work

　View Summary

アステルトキシンのノンクロモフォア部分を合成した。（６頁）

Synthesis of a bicyclic hexapeptide　as a plausible active center in vancomycin.

鈴木良一、西山　繁、山村庄亮

Tetrahedron Lett.  1990

Joint Work

　View Summary

バンコマイシンの活性中心である二環性ヘキサペプチドを合成した。（４頁）

Evaluation of two possible transition　states in intramolecular oxetane / oxolane　ring formation based on AM1 calculations

西山　繁、山村庄亮、加藤國基、永井雅史、滝田智久、寺田幸正

Tetrahedron Lett.  1990

Joint Work

　View Summary

AM1 計算に基づき、分子内オキセタンとオキソラン環生成のための遷移状態について考察した。（４頁）

Synthetic studies on novel sulfur-　containing alkaloids, prianosins isolated　from the marine sponge Prianos melanos.　Synthesis of the spirodienone moiety by　phenolic oxidation.

程　傑飛、西山　繁、山村庄亮

Chem. Lett.  1990

Joint Work

　View Summary

含硫黄アルカロイドプリアノシンのスピロジエノン部分を合成した。（４頁）

Synthetic studies on fully substituted γ-pyrone-containing natural products: synthesis of γ-pyrone derivatives obtained　by decomposition of peroniatriols.

有本博一、西山　繁、山村庄亮

Tetrahedron Lett.  1990

Joint Work

　View Summary

海洋天然物ペロニアトリオール類の分解産物である光学活性ピロン誘導体を合成した。（４頁）

Mild conditions for cyclization of β-triketides to the corresponding γ-pyrones　carrying adjacent chiral centers toward　biomimetic synthesis of fully substituted　γ-pyrone-containing natural products.

有本博一、西山　繁、山村庄亮

Tetrahedron Lett.  1990

Joint Work

　View Summary

光学活性トリケトンからγ-ピロンへの温和な変換反応を報告した。（２頁）

An improved, practical synthesis of the　derivatives of 1-O-acetyl-2-deoxy-2-hydroxy-methyl-D-erythro-oxetanose, a　key sugar moiety for the synthesis of　oxetanosyl-N-glycoside.

永井雅史、加藤國基、滝田智久、西山　繁、山村庄亮

Tetrahedron  1990

Joint Work

　View Summary

詳報として、オキセタノシン型ヌクレオシド合成の中間体となるオキセタノース誘導体の合成を報告した。（８頁）

Isodityrosine を含む新しい生理活性オリゴペプチドの合成.

西山　繁、山村庄亮

THE CHEMICAL TIMES  1989

Research paper (scientific journal), Joint Work

　View Summary

イソジチロシン類についての解説（１０頁）

Biomimetic synthesis and stereostructure　of K-13, a novel inhibitor of angiotensin I　converting enzyme.

西山　繁、鈴木良一、山村庄亮

Tetrahedron Lett.  1989

Joint Work

　View Summary

アンジオテンシンＩ変換酵素阻害剤Ｋ-１３の生合成類似（４頁）

A novel method for the synthesis of　anomerically allylated C- glycosides, an　unusual Lewis acid-catalysed rearrangement　of an oxetanosyl-N-glycoside to furanosyl-C-glyoside

加藤國基、南　孝枝、滝田智久、西山　繁、扇谷忠明、山村庄亮

Chem. Commun.  1989

Joint Work

　View Summary

異常ルイス酸触媒によるオキセタノシルＮ-グリコシドからアリルフラノシルＣ-グリコシドへの変換反応について報告した。（２頁）

Synthetic study on vancomycin:　synthesis of a macrocyclic tetrapeptide as　a plausible active center in vancomycin.

鈴木良一、西山　繁、山村庄亮

Tetrahedron Lett.  1989

Joint Work

　View Summary

バンコマイシンの活性中心と考えられる環状テトラペプチドを合成した。（４頁）

Synthetic study on aplysiatoxins, highly　inflammatory agents and tumor promoters. Synthesis of the three optically active　segments.

戸嶋浩明、吉田真一、鈴木孝之、西山　繁、山村庄亮

Tetrahedron Lett.  1989

Joint Work

　View Summary

アプリシアトキシン合成のための３種類の光学活性合成素子を合成した。（４頁）

Synthetic study on aplysiatoxins, highly　inflammatory agents and tumor promoters. Synthesis of 3-deoxydebromoaplysiatoxin.

戸嶋浩明、鈴木孝之、西山　繁、山村庄亮

Tetrahedron Lett.  1989

Joint Work

　View Summary

３-デオキシデブロモアプリシアトキシンを合成した。（４頁）

2,3-Dihydropyranones with contiguous　chiral centers: practical routes for their　acquisition and evaluation of their reaction　potential.

F. W. Lichtenthaler、西山　繁、T. Weimer

Liebigs Ann. Chem.  1989

Joint Work

　View Summary

不斉炭素を有する２,３-ジヒドロピラノンについて、合成法と反応性を調べた。（８頁）

Synthetic study on breynin A: synthesis of　breynolide sulfone.

西山　繁、池田洋一、吉田真一、山村庄亮

Tetrahedron Lett.  1989

Joint Work

　View Summary

ブレイニンＡに関連して、そのスルホン誘導体を合成した。（４頁）

Total synthesis and the absolute　configuration of aurovertin B, an acute　neurotoxic metabolite

西山　繁、戸嶋浩明、金井宏樹、山村庄亮

Tetrahedron  1988

Joint Work

　View Summary

オーロベルチンＢを全合成し、絶対構造を決定した。（１０頁）

A total synthesis of oxetanocin, a novel　nucleoside with an oxetane ring.

西山　繁、山村庄亮、加藤國基、滝田智久

Tetrahedron Lett.  1988

Joint Work

　View Summary

新規ヌクレオシド抗生物質オキセタノシンを全合成した。（４頁）

Synthetic studies on oxetanocin, a novel　nucleoside with an oxetane ring, synthesis　 of some chiral D-oxetanosyl acylates.

西山　繁、山村庄亮、加藤國基、滝田智久

Tetrahedron Lett.  1988

Joint Work

　View Summary

オキセタノシンの合成に関して、オキセタノシルアセテートの合成を報告した。（４頁）

Total synthesis of OF-4949-III, a novel　inhibitor of aminopeptidase B.

西山　繁、鈴木良一、山村庄亮

Tetrahedron Lett.  1988

Joint Work

　View Summary

アミノペプチダーゼＢ阻害剤OF-4949-IIIを全合成した。（４頁）

Isolation, structural elucidation, and total　synthesis of epineocitreoviridinol.

西山　繁、志津里芳一、戸嶋浩明、尾崎雅美、山村庄亮、河井一明、河井紀明、'古川秀之

Chem. Lett.  1987

Joint Work

　View Summary

エピネオシトレオビリジノールの単離、構造決定および全合成について報告した。（４頁）

Total syntheses of citreoviridinol and　neocitreoviridinol.

西山　繁、戸嶋浩明、山村庄亮

Tetrahedron Lett.  1986

Joint Work

　View Summary

シトレオビリジノールとネオシトレオビリジノールを全合成した。（４頁）

Total syntheses of (+/-)-aerothionin,　(+/-)-homoaerothionin, and (+/-)-　aerophobin-1.

西山　繁、山村庄亮

Bull. Chem. Soc. Jpn.  1986

Joint Work

　View Summary

(+/-)-アエロチオニン、(+/-)-ホモアエロチオニンおよびアエロホビン-１の合成に関して報告した。（４頁）

Synthetic study on verrucosidin and its　absolute configuration.

西山　繁、志津里芳一、繁森英幸、山村庄亮

Tetrahedron Lett.  1986

Joint Work

　View Summary

ベルコシジンの絶対構造を合成的に決定した。（４頁）

Syntheses of some 6-oxa- and 2,8-　dioxabicyclo[3.2.1]octanes in connection　with the daphni- phyllum alkaloids.

西山　繁、池田洋一、山村庄亮

Bull. Chem. Soc. Jpn.  1986

Joint Work

　View Summary

ダフニフィリウムアルカロイドの合成に関連して二環性化合物を合成した。（４頁）

Total synthesis and the absolute　configuration of aurovertin B.

西山　繁、戸嶋浩明、金井宏樹、山村庄亮

Tetrahedron Lett.  1986

Joint Work

　View Summary

オーロベルチンＢを全合成し、絶対構想を決定した。（４頁）

Synthesis of piperazinomycin, a novel　antifungal antibiotic.

西山　繁、中村和彦、鈴木良一、山村庄亮

Tetrahedron Lett.  1986

Joint Work

　View Summary

新規抗真菌性抗生物質ピペラジノマイシンを合成した。（４頁）

Isolation and stereostructures of　neocitreoviridinol and　epineocitreoviridinol.

西山　繁、志津里芳一、山村庄亮、寺田幸正、河井一明、古川秀之

Tetrahedron Lett.  1985

Joint Work

　View Summary

ネオシトレオビリジノールとエピネオシトレオビリジノールを単離し、立体構造を決定した。（４頁）

Total synthesis and the absolute　configuration of citreoviral and　citreoviridin.

西山　繁、志津里芳一、山村庄亮

Tetrahedron Lett.  1985

Joint Work

　View Summary

シトレオビラールおよびシトレオビリジンの全合成を達成し、それらの絶対構造を決定した。（４頁）

Total synthesis of (+/-)-citreoviral.

志津里芳一、西山　繁、繁森英幸、山村庄亮

Chem. Commun.  1985

Joint Work

　View Summary

(+/-)-シトレオビラールを全合成した。（２頁）

Anomeric stereocontrol in addition　reactions to hexose-derived　dihydropyranones.

F. W. Lichtenthaler、西山　繁、P. Koehler、H. J. Lindner

Carbohydr. Res.  1985

Joint Work

　View Summary

ヘキソース由来のジヒドロピラノンに対する付加反応について、アノマー位の立体制御効果を研究した。（1４頁）

Structural and conformational studies on　 citreoviridinol and isocitreoviridinol:　syntheses of some 2,6-dioxabicyclo〔3.2.1〕octanes

西山　繁、志津里芳一、今井大蔵、山村庄亮、寺田幸正、丹羽正武、河井一明、古川秀之、

Tetrahedron Lett.  1985

Joint Work

　View Summary

シトレオビリジンとイソシトレオビリジンの立体構造を合成的に決定した。（４頁）

Isolation and stereostructures of　citreoviral, citreodiol, and epicitreodiol.

志津里芳一、西山　繁、今井大蔵、山村庄亮、古川秀之、河井一明、岡田信男

Tetrahedron Lett.  1984

Joint Work

　View Summary

シトレオビラール、シトレオジオールおよびエピシトレオジオールを単離し、それらの立体構造を決定した。（４頁）

Total synthesis of (+/-)-aerothionin and　 (+/-)-homoaerothionin.

西山　繁、山村庄亮

Tetrahedron Lett.  1983

Joint Work

　View Summary

アエロチオニンおよびホモアエロチオニンを全合成した。（２頁）

Total synthesis of bastadin-6, a　brominated tyrosine-derived metabolite from the sponge Ianthella basta.

西山　繁、鈴木伴子、山村庄亮

Chem. Lett.  1982

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海綿より得られる臭素化チロシン由来のバスタジン-６を全合成した。（２頁）

Total synthesis of bastadins.

西山　繁、山村庄亮

Tetrahedron Lett.  1982

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鎖状バスタジン類を全合成した。（４頁）

Synthesis of bastadin-6 trimethyl ether,　a novel 28-membered ring lactam.

西山　繁、鈴木伴子、山村庄亮

Tetrahedron Lett.  1982

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２８員環バスタジン-６トリメチルエーテルを合成した。（４頁）

Thallium (III) trifluoroacetate oxidation of　some esters having two C6 - C3 units.

西山　繁、山村庄亮

Chem. Lett.  1979

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C6 - C3 ユニットを持つエステル類のトリフルオロ酢酸タリウムによる酸化反応を研究した。（４頁）

Novel, highly stereoselective　rearrangements of chiral dihydropyranones.

F. W. Lichtenthaler、西山　繁、P. Jarglis

Angew. Chem. Int. Ed. Engl.  1979

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光学活性ジヒドロピラノン類の新規高選択的転位反応を見出した。（３頁）

Modification of aminocyclitol antibiotics.　6. Preparation of 5-deoxykanamycin B.

須網哲夫、西山　繁、石川甚秀、梅村英次郎

Bull. Chem. Soc. Jpn.  1978

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アミノサイクリトール抗生物質の合成の一環として、5-デオキシカナマイシンＢを合成した。（４頁）

Chemical modification of neamine. Part. IV.

須網哲夫、西山　繁、石川甚秀、桂　慎一

Carbohydr. Res.  1978

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ネアミンの化学修飾としてエピネアミン類を合成した。（８頁）

Chemical modification of neamine. 5.　Preparation of aminodeoxy- neamines.

須網哲夫、西山　繁、石川甚秀、桂　慎一

Bull. Chem. Soc. Jpn.  1978

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ネアミンの化学修飾。５。アミノデオキシネアミン類の合成。（４頁）

Synthesis of stachyose tetradeca-acetate and an isomer.

須網哲夫、大竹敏樹、西山　繁、安達良一、中村克巳

Bull. Chem. Soc. Jpn.  1978

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スタキオースのテトラデカアセテートを合成した。（４頁）

Synthesis of tetrahydrospectinomycin.

須網哲夫、西山　繁、石川　光、岡田　博、木下　健

Bull. Chem. Soc. Jpn.  1977

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テトラヒドロスぺクチノマイシンの合成（４頁）

Chemical modification of neamine.

須網哲夫、西山　繁、石川甚秀、桂　慎一

Carbohydr. Res.  1977

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ネアミンの化学修飾を行い、デオキシネアミン類を合成した。（８頁）

Chemical modification of neamine. Part. III.

須網哲夫、西山　繁、石川甚秀、桂　慎一

Carbohydr. Res.  1977

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ネアミンの化学修飾。（４頁）

Chemical modification of aminocyclitol　antibiotics.

須網哲夫、西山　繁、石川甚秀、桂　慎一

Carbohydr. Res.  1976

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アミノサイクリトール抗生物質の化学修飾（１０頁）

Synthesis of (2-chloroethyl)-nitroso urea　derivatives of carbohydrates.

町並智也、西山　繁、菊池和夫、須網哲夫

Bull. Chem. Soc. Jpn.  1975

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糖類の２-クロロエチルニトロソウレア誘導体を合成した。（２頁）

Sucrose chemistry. 6. 　Synthesis of amino derivatives of sucrose.

須網哲夫、池田敏秀、西山　繁、安達良一

Bull. Chem. Soc. Jpn.  1975

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選択的な反応でショ糖にアミノ基を導入した。（２頁）

Aminocyclitols. 30. Unambiguous　synthesis of seven aminocyclopentanetetrols.

須網哲夫、只野金一、西山　繁、F. W. Lichtenthaler

J. Org. Chem.  1973

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７種類のアミノペンタンテトロールを確実な方法で合成した。（６頁）

Nucleoside analogs. III. synthesis of　carbocyclic adenosine analogs.

須網哲夫、西山　繁、只野金一、F. W. Lichtenthaler

Bull. Chem. Soc. Jpn.  1973

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炭素５員環ヌクレオシド類縁体を合成した。（３頁）

Aminocyclitols. XXVI. Synthesis　of aminocyclopentanetetrols.

須網哲夫、迫田幸生、只野金一、西山　繁

Bull. Chem. Soc. Jpn.  1971

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アミノシクロペンタンテトロール類を立体選択的に合成した。（４頁）