Suenaga, Kiyotake

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry （Yagami）

Position

Professor

Related Websites

External Links
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Career 【 Display / hide 】

  • 1995.03
    -
    1996.03

    名古屋大学理学部助手

  • 1996.04
    -
    2001.03

    名古屋大学大学院理学研究科助手

  • 2001.04
    -
    2003.03

    静岡県立大学薬学部助手

  • 2003.04
    -
    2004.03

    筑波大学化学系講師

  • 2004.04
    -
    2006.03

    筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide 】

  • 1992.03

    Nagoya University, Faculty of Science, Department of Chemistry

    University, Graduated

  • 1995.02

    Nagoya University, 理学研究科, 化学専攻

    Graduate School, Withdrawal before completion, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（理学）, 名古屋大学, Dissertation, 1997.03

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules (Natural Products Chemistry)

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Research Keywords 【 Display / hide 】

  • Total Synthesis

  • Isolation and Structure Determination

  • Mode of Action

  • Marine Cyanobacteria

  • Bioactive Substances

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Books 【 Display / hide 】

  • 天然物化学II—自然からの贈り物—、科学のとびら64

    末永 聖武, 東京化学同人, 2018

    Scope: ビセリングビアサイドの化学

  • 天然物化学—魅力と展望— 科学のとびら60

    末永 聖武, 東京化学同人, 2016

    Scope: ラン藻類の化学

  • Marine Pharmacognosy: Trends and Applications

    Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

    Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

  • ソレル　有機化学

    SUENAGA Kiyotake, 東京化学同人, 2009.12

    Scope: 551-610

  • 天然物化学—海洋生物編

    末永聖武、照屋俊明, アイピーシー, 2008

    Scope: サンゴの生態化学

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Papers 【 Display / hide 】

  • Kagimminols A and B, Cembrene-Type Diterpenes from an Okeania sp. Marine Cyanobacterium

    Ebihara A., Taguchi R., Jeelani G., Nozaki T., Suenaga K., Iwasaki A.

    Journal of Natural Products （Journal of Natural Products)  87 （ 4 ） 1116 - 1123 2024.04

    ISSN  01633864

    　View Summary

    Kagimminols A (1) and B (2), new cembrene-type diterpenoids, were isolated from an Okeania sp. marine cyanobacterium. By combining DP4 analysis with an efficient NMR chemical shift calculation protocol, we clarified the relative configurations of 1 and 2 without consuming precious natural products. We determined the absolute configurations by a comparison of theoretical electronic circular dichroism (ECD) spectra with experimental spectra, and the absolute configuration of 1 was verified experimentally. Finally, we found that 1 and 2 showed selective growth-inhibitory activity against the causative agent of human African trypanosomiasis. This study exemplifies that computational chemistry is an efficient tool for clarifying the configurations of natural products possessing tautomers in equilibrium.

  • Isolation and structure determination of a new analog of polycavernosides from marine Okeania sp. cyanobacterium

    Umeda K., Kurisawa N., Jeelani G., Nozaki T., Suenaga K., Iwasaki A.

    Beilstein Journal of Organic Chemistry （Beilstein Journal of Organic Chemistry)  20   645 - 652 2024

    　View Summary

    Polycavernoside E (1), a new polycavernoside analog, was isolated from a marine Okeania sp. cyanobacterium. The relative configuration was elucidated primarily by analyzing the two dimensional nuclear magnetism resonance (2D NMR) data. The absolute configuration was clarified by comparing the electronic circular dichroism (ECD) data of 1 with those of known analogs. Polycavernoside E (1) exhibited moderate antitrypanosomal activity against Trypanosoma brucei rhodesiense. Furthermore, the isolation of polycavernoside E (1) from marine cyanobacteria provides additional evidence that marine cyanobacteria, and not red algae, are responsible for the biosynthesis of polycavernosides.

  • Allelopathic potential of Oldenlandia corymbosa and identification of its allelopathic substances

    Kyaw E.H., Hossen K., Iwasaki A., Suenaga K., Kato-Noguchi H.

    Plant Biosystems （Plant Biosystems)  158 （ 3 ） 394 - 403 2024

    ISSN  11263504

    　View Summary

    The use of allelopathy developed as an alternative practice for weed management in agriculture. Oldenlandia corymbosa is an annual herb and notable for being applied in folk medicine. Its diverse range of pharmacological properties and several bioactive substances have been well reported. Nevertheless, the allelopathic potential of O. corymbosa has not yet been documented. Hence, we aim to explore the allelopathy of O. corymbosa for weed control purposes. The extracts of O. corymbosa were tested to determine their effects on the seedling growth of six tested species. Significant reductions in the growth of seedling were exhibited as the plant extract concentrations increased. The plant extracts of O. corymbosa were separated in several chromatography steps; two active substances isolated and characterized as hedyotiscone A and B. Hedyotiscone A and B significantly restricted the growth of cress seedling at concentrations higher than 0.3 mM. The I50 values of hedyotiscone A and B for the cress seedlings ranged from 0.023 to 0.131 mM and 0.167 to 0.810 mM, respectively. The inhibitory activity against cress seedlings indicates that hedyotiscone A and B contribute to the allelopathic effects and may be responsible for the allelopathic potential of O. corymbosa.

  • Isolation and Structure Determination of Akunolides, Macrolide Glycosides from a Marine Okeania sp. Cyanobacterium

    Umeda K., Iwasaki A., Taguchi R., Kurisawa N., Jeelani G., Nozaki T., Suenaga K.

    Journal of Natural Products （Journal of Natural Products)  86 （ 11 ） 2529 - 2538 2023.11

    ISSN  01633864

    　View Summary

    Akunolides A (1), B (2), C (3), and D (4), new macrolide glycosides, were isolated from a marine Okeania sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and derivatization reactions. Akunolides A-D (1-4) are classified as 16-membered macrolide glycosides, which are relatively rare structures for marine cyanobacterium-derived natural products. Akunolides A-D (1-4) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense, with IC50 values ranging from 11 to 14 μM. Furthermore, akunolides A (1) and C (3) exhibited no cytotoxicity against normal human WI-38 cells even at a concentration of 150 μM.

  • Fumagillin inhibits growth of the enteric protozoan parasite Entamoeba histolytica by covalently binding to and selectively inhibiting methionine aminopeptidase 2

    Watanabe N., Saito-Nakano Y., Kurisawa N., Otomo K., Suenaga K., Nakano K., Nozaki T.

    Antimicrobial Agents and Chemotherapy （Antimicrobial Agents and Chemotherapy)  67 （ 11 ）  2023.11

    ISSN  00664804

    　View Summary

    Amebiasis is an important cause of morbidity and mortality worldwide, and caused by infection with the protozoan parasite Entamoeba histolytica. Metronidazole is currently the first-line drug despite adverse effects and concerns on the emergence of drug resistance. Fumagillin, a fungal metabolite from Aspergillus fumigatus, and its structurally related natural and synthetic compounds have been previously explored as potential anti-angiogenesis inhibitors for cancers, anti-microbial, and anti-obese compounds. Although fumagillin was used for human amebiasis in clinical trials in 1950s, the mode of action of fumagillin remains elusive until now. In this report, we showed that fumagillin covalently binds to methionine aminopeptidase 2 (MetAP2) and non-covalently but abundantly binds to patatin family phospholipase A (PLA). Susceptibility against fumagillin of the amebic strains in which expression of E. histolytica MetAP2 (EhMetAP2) gene was silenced increased compared to control strain. Conversely, overexpression of EhMetAP2 mutants that harbors amino acid substitutions responsible for resistance to ovalicin, a fumagillin analog, in human MetAP2, also resulted in decrease in fumagillin susceptibility. In contrast, neither gene silencing nor overexpression of E. histolytica PLA (EhPLA) affected fumagillin susceptibility. These data suggest that EhPLA is not essential and not the target of fumagillin for its amebicidal activity. Taken together, our data have demonstrated that EhMetAP2 is the primary target for amebicidal activity of fumagillin, and EhMetAP2 represents a rational explorable target for the development of alternative therapeutic agents against amebiasis.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 粟国島産未記載種海洋シアノバクテリア由来Terukufazoline類の単離、構造決定、生物活性および合成研究

    田口黎武、海老原玲、恒松雄太、Ghulam Jeelani、野崎智義、末永聖武、岩崎有紘

    第65回天然有機化合物討論会 (東京大学安田講堂) , 

    2023.09
    , 

    Oral presentation (general)

  • 粟国島産未記載種海洋シアノバクテリア由来Terukufazoline類の単離、構造決定、生物活性および合成研究

    田口黎武、海老原玲、恒松雄太、Ghulam Jeelani、野崎智義、末永聖武、岩崎有紘

    第69回トキシンシンポジウム (京都産業大学) , 

    2023.09
    , 

    Oral presentation (general)

  • 海洋シアノバクテリア由来新規鎖状ペプチド hedoamide の構造と生物活性

    栗澤 尚瑛、岩﨑 有紘、Ghulam Jeelani、Yulia Rahmawati、野崎 智義、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03
    , 

    Oral presentation (general)

  • Biselyngbyaside 人工類縁体の合成研究

    先山 佳寿、岩崎 有紘、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03
    , 

    Oral presentation (general)

  • 海洋シアノバクテリア由来の新規配糖体マクロリドakunolide類の単離及び構造決定

    梅田 海里、岩崎 有紘、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 海洋シアノバクテリア由来の熱帯病治療薬リード化合物の創製

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2017.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

    2016.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Cultivation of Useful Marine Cyanobacteria and Analysis of Biosynthetic genes

    2016.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Principal investigator

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Awards 【 Display / hide 】

  • The CSJ Award for Young Chemists

    SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 井上研究奨励賞

    SUENAGA Kiyotake, 1998.02, 井上科学振興財団

    Type of Award： Award from publisher, newspaper, foundation, etc.

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Courses Taught 【 Display / hide 】

  • SEMINAR IN CHEMISTRY

    2024

  • ORGANIC STRUCTURAL DETERMINATION

    2024

  • MICROBIOLOGY

    2024

  • LABORATORY IN SCIENCE

    2024

  • LABORATORIES IN CHEMISTRY 2

    2024

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Memberships in Academic Societies 【 Display / hide 】

  • 日本薬学会, 

    2001.04
    -
    Present

  • 有機合成化学協会, 

    1995.04
    -
    Present

  • 日本化学会, 

    1992.04
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2023.04
    -
    Present

    世話人, 天然有機化合物討論会

  • 2023.03
    -
    Present

    副会長, 私立大学環境保全協議会

  • 2015.04
    -
    Present

    理事, 私立大学環境保全協議会

  • 2014.04
    -
    Present

    企画委員, 私立大学環境保全協議会

  • 2013.01
    -
    2013.03

    審査員, 関東地区化学クラブ発表会

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