Suenaga, Kiyotake

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Professor

Related Websites

External Links

Career 【 Display / hide

  • 1995.03
    -
    1996.03

    名古屋大学理学部助手

  • 1996.04
    -
    2001.03

    名古屋大学大学院理学研究科助手

  • 2001.04
    -
    2003.03

    静岡県立大学薬学部助手

  • 2003.04
    -
    2004.03

    筑波大学化学系講師

  • 2004.04
    -
    2006.03

    筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide

  • 1992.03

    Nagoya University, Faculty of Science, Department of Chemistry

    University, Graduated

  • 1995.02

    Nagoya University, 理学研究科, 化学専攻

    Graduate School, Withdrawal before completion, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(理学), 名古屋大学, Dissertation, 1997.03

 

Research Areas 【 Display / hide

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules (Natural Products Chemistry)

Research Keywords 【 Display / hide

  • Total Synthesis

  • Isolation and Structure Determination

  • Mode of Action

  • Marine Cyanobacteria

  • Bioactive Substances

 

Books 【 Display / hide

  • 天然物化学II—自然からの贈り物—、科学のとびら64

    末永 聖武, 東京化学同人, 2018

    Scope: ビセリングビアサイドの化学

  • 天然物化学—魅力と展望— 科学のとびら60

    末永 聖武, 東京化学同人, 2016

    Scope: ラン藻類の化学

  • Marine Pharmacognosy: Trends and Applications

    Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

    Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

  • ソレル 有機化学

    SUENAGA Kiyotake, 東京化学同人, 2009.12

    Scope: 551-610

  • 天然物化学—海洋生物編

    末永聖武、照屋俊明, アイピーシー, 2008

    Scope: サンゴの生態化学

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Papers 【 Display / hide

  • Total synthesis of acetylene-containing lipopeptides odookeanynes A and B

    Lo Y.H., Umeda K., Kurisawa N., Jeelani G., Nozaki T., Suenaga K.

    Tetrahedron Letters (Tetrahedron Letters)  130 2023.10

    ISSN  00404039

     View Summary

    The total synthesis of acetylene-containing lipopeptides odookeanynes A (1) and B (2), isolated from the marine cyanobacterium Okeania sp., has been achieved. A biological evaluation using synthetic odookeanynes revealed their potent antitrypanosomal activity. This report not only describes a synthetic pathway for structurally related compounds for SAR studies but also offers new insights into their potential as antiparasitic agents.

  • Total Synthesis of Ikoamide, a Highly N-Methylated Antimalarial Lipopeptide

    Lo Y.H., Iwasaki A., Suenaga K.

    Journal of Organic Chemistry (Journal of Organic Chemistry)  88 ( 15 ) 10565 - 10573 2023.08

    ISSN  00223263

     View Summary

    Ikoamide (1) is a highly N-methylated antimalarial lipopeptide that was isolated from a marine cyanobacterium, an Okeania sp. in 2018, which shows strong antimalarial activity without cytotoxicity against human cancer cell lines. To establish a synthetic method for obtaining enough ikoamide for its biological evaluations, we have established a total synthesis of ikoamide. The synthetic method presented here lays the foundation for the development of novel ikoamide analogues, which may lead to a discovery of pharmaceutically unique antimalarial drug leads.

  • Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes

    Ozaki K., Asato Y., Natsume N., Tojo S., Sumimoto S., Iwasaki A., Suenaga K., Teruya T.

    Journal of Natural Products (Journal of Natural Products)  86 ( 6 ) 1564 - 1570 2023.06

    ISSN  01633864

     View Summary

    The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemical degradations, Marfey’s analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.

  • Unique Initiation and Termination Mechanisms Involved in the Biosynthesis of a Hybrid Polyketide-Nonribosomal Peptide Lyngbyapeptin B Produced by the Marine Cyanobacterium Moorena bouillonii

    Kudo F., Chikuma T., Nambu M., Chisuga T., Sumimoto S., Iwasaki A., Suenaga K., Miyanaga A., Eguchi T.

    ACS Chemical Biology (ACS Chemical Biology)  18 ( 4 ) 875 - 883 2023.04

    ISSN  15548929

     View Summary

    Lyngbyapeptin B is a hybrid polyketide-nonribosomal peptide isolated from particular marine cyanobacteria. In this report, we carried out genome sequence analysis of a producer cyanobacterium Moorena bouillonii to understand the biosynthetic mechanisms that generate the unique structural features of lyngbyapeptin B, including the (E)-3-methoxy-2-butenoyl starter unit and the C-terminal thiazole moiety. We identified a putative lyngbyapeptin B biosynthetic (lynB) gene cluster comprising nine open reading frames that include two polyketide synthases (PKSs: LynB1 and LynB2), four nonribosomal peptide synthetases (NRPSs: LynB3, LynB4, LynB5, and LynB6), a putative nonheme diiron oxygenase (LynB7), a type II thioesterase (LynB8), and a hypothetical protein (LynB9). In vitro enzymatic analysis of LynB2 with methyltransferase (MT) and acyl carrier protein (ACP) domains revealed that the LynB2 MT domain (LynB2-MT) catalyzes O-methylation of the acetoacetyl-LynB2 ACP domain (LynB2-ACP) to yield (E)-3-methoxy-2-butenoyl-LynB2-ACP. In addition, in vitro enzymatic analysis of LynB7 revealed that LynB7 catalyzes the oxidative decarboxylation of (4R)-2-methyl-2-thiazoline-4-carboxylic acid to yield 2-methylthiazole in the presence of Fe2+ and molecular oxygen. This result indicates that LynB7 is responsible for the last post-NRPS modification to give the C-terminal thiazole moiety in lyngbyapeptin B biosynthesis. Overall, we identified and characterized a new marine cyanobacterial hybrid PKS-NRPS biosynthetic gene cluster for lyngbyapeptin B production, revealing two unique enzymatic logics.

  • Isolation of Hennaminal and Isolation and Total Synthesis of Hennamide, Pyrrolinone Compounds from the Marine Cyanobacterium Rivularia sp.

    Takahashi H., Iwasaki A., Ebihara A., Taguchi R., Jeelani G., Nozaki T., Suenaga K.

    Organic Letters (Organic Letters)  25 ( 14 ) 2400 - 2404 2023.04

    ISSN  15237060

     View Summary

    Two new natural products were isolated from the marine cyanobacterium Rivularia sp. collected in Japan. Hennaminal possesses a very rare functional group, β,β-diamino unsaturated ketone, which has only been found in bohemamine-type natural products so far. Hennamide possesses a reactive N-acyl pyrrolinone moiety, which induces self-dimerization. The isolation and structure determination supported by computational chemistry and total synthesis, as well as the antitrypanosomal activities of hennaminal and hennamide are described.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Presentations 【 Display / hide

  • 粟国島産未記載種海洋シアノバクテリア由来Terukufazoline類の単離、構造決定、生物活性および合成研究

    田口黎武、海老原玲、恒松雄太、Ghulam Jeelani、野崎智義、末永聖武、岩崎有紘

    第65回天然有機化合物討論会 (東京大学安田講堂) , 

    2023.09

    Oral presentation (general)

  • 粟国島産未記載種海洋シアノバクテリア由来Terukufazoline類の単離、構造決定、生物活性および合成研究

    田口黎武、海老原玲、恒松雄太、Ghulam Jeelani、野崎智義、末永聖武、岩崎有紘

    第69回トキシンシンポジウム (京都産業大学) , 

    2023.09

    Oral presentation (general)

  • 海洋シアノバクテリア由来新規鎖状ペプチド hedoamide の構造と生物活性

    栗澤 尚瑛、岩﨑 有紘、Ghulam Jeelani、Yulia Rahmawati、野崎 智義、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03

    Oral presentation (general)

  • Biselyngbyaside 人工類縁体の合成研究

    先山 佳寿、岩崎 有紘、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03

    Oral presentation (general)

  • 海洋シアノバクテリア由来の新規配糖体マクロリドakunolide類の単離及び構造決定

    梅田 海里、岩崎 有紘、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 海洋シアノバクテリア由来の熱帯病治療薬リード化合物の創製

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2019.06
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    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2017.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

    2016.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Cultivation of Useful Marine Cyanobacteria and Analysis of Biosynthetic genes

    2016.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Principal investigator

Awards 【 Display / hide

  • The CSJ Award for Young Chemists

    SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • 井上研究奨励賞

    SUENAGA Kiyotake, 1998.02, 井上科学振興財団

    Type of Award: Award from publisher, newspaper, foundation, etc.

 

Courses Taught 【 Display / hide

  • TOPICS IN BIOORGANIC CHEMISTRY

    2023

  • SEMINAR IN CHEMISTRY

    2023

  • ORGANIC STRUCTURAL DETERMINATION

    2023

  • MICROBIOLOGY

    2023

  • LABORATORY IN SCIENCE

    2023

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Memberships in Academic Societies 【 Display / hide

  • 日本薬学会, 

    2001.04
    -
    Present
  • 有機合成化学協会, 

    1995.04
    -
    Present
  • 日本化学会, 

    1992.04
    -
    Present

Committee Experiences 【 Display / hide

  • 2023.04
    -
    Present

    世話人, 天然有機化合物討論会

  • 2023.03
    -
    Present

    副会長, 私立大学環境保全協議会

  • 2015.04
    -
    Present

    理事, 私立大学環境保全協議会

  • 2014.04
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    Present

    企画委員, 私立大学環境保全協議会

  • 2013.01
    -
    2013.03

    審査員, 関東地区化学クラブ発表会

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