Suenaga, Kiyotake

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Professor

Related Websites

External Links

Career 【 Display / hide

  • 1995.03
    -
    1996.03

    名古屋大学理学部助手

  • 1996.04
    -
    2001.03

    名古屋大学大学院理学研究科助手

  • 2001.04
    -
    2003.03

    静岡県立大学薬学部助手

  • 2003.04
    -
    2004.03

    筑波大学化学系講師

  • 2004.04
    -
    2006.03

    筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide

  • 1992.03

    Nagoya University, Faculty of Science, Department of Chemistry

    University, Graduated

  • 1995.02

    Nagoya University, 理学研究科, 化学専攻

    Graduate School, Withdrawal before completion, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(理学), 名古屋大学, Dissertation, 1997.03

 

Research Areas 【 Display / hide

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules (Natural Products Chemistry)

Research Keywords 【 Display / hide

  • Total Synthesis

  • Isolation and Structure Determination

  • Mode of Action

  • Marine Cyanobacteria

  • Bioactive Substances

 

Books 【 Display / hide

  • 天然物化学II—自然からの贈り物—、科学のとびら64

    末永 聖武, 東京化学同人, 2018

    Scope: ビセリングビアサイドの化学

  • 天然物化学—魅力と展望— 科学のとびら60

    末永 聖武, 東京化学同人, 2016

    Scope: ラン藻類の化学

  • Marine Pharmacognosy: Trends and Applications

    Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

    Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

  • ソレル 有機化学

    SUENAGA Kiyotake, 東京化学同人, 2009.12

    Scope: 551-610

  • 天然物化学—海洋生物編

    末永聖武、照屋俊明, アイピーシー, 2008

    Scope: サンゴの生態化学

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Papers 【 Display / hide

  • Two Allelopathic Substances from Plumbago rosea Stem Extracts and Their Allelopathic Effects

    Lun T.L., Iwasaki A., Suenaga K., Kato-Noguchi H.

    Agronomy (Agronomy)  12 ( 9 )  2022.09

     View Summary

    The plant Plumbago rosea Linn., belonging to the Plumbaginaceae family, is an important medicinal herb distributed in part of Southeast Asia, and there are many reports of its pharmacological properties. However, the allelopathic activities of P. rosea have not been examined. Thus, the present study was conducted to assess the allelopathic activity of P. rosea and to identify its allelopathic substances. The aqueous methanol stem extract of P. rosea significantly suppressed the seedling growth of barnyard grass (Echinochloa crus-galli L. P. Beauv.), Italian ryegrass (Lolium multiflorum Lam.), timothy (Phleum pretense L.), cress (Lepidium sativum L.), lettuce (Lactuca sativa L.), and alfalfa (Medicago sativa L.). The extract of P. rosea was then purified through chromatographic steps, and two active substances were isolated and determined as 7,4′,5′-tri-O-methyl dihydroquercetin and 7,4′,5′-tri-O-methylampelopsin. The two compounds significantly inhibited the seedling growth of cress, with 7,4′,5′-tri-O-methylampelopsin showing a greater inhibitory effect than 7,4′,5′-tri-O-methyl dihydroquercetin. This result may be due to the 3′-OH group in 7,4′,5′-tri-O-methylampelopsin. The effective concentrations of both compounds required for 50% growth inhibition (EC50 values) of cress seedlings were 0.24 mM and 0.59 mM for root and shoot, and 0.07 mM and 0.21 mM, respectively. These findings suggest that the two compounds may contribute to the allelopathic effect of P. rosea and could be used as a natural source of allelopathic substances.

  • Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp.

    Taguchi R., Iwasaki A., Ebihara A., Jeelani G., Nozaki T., Suenaga K.

    Organic Letters (Organic Letters)  24 ( 25 ) 4710 - 4714 2022.07

    ISSN  15237060

     View Summary

    A 68 μg amount of an acyclic polyketide, named beru'amide, was isolated from a marine cyanobacterium Okeania sp. Beru'amide contains six unique moieties in its relatively small skeleton. By applying several cutting-edge techniques, including DFT-based chemical shift calculations, we achieved the structure determination and the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide was shown to have strong antitrypanosomal activity. 2022 American Chemical Society.

  • Isolation of Caldorazole, a Thiazole-Containing Polyketide with Selective Cytotoxicity under Glucose-Restricted Conditions

    Ohno O., Iwasaki A., Same K., Kudo C., Aida E., Sugiura K., Sumimoto S., Teruya T., Tashiro E., Simizu S., Matsuno K., Imoto M., Suenaga K.

    Organic Letters (Organic Letters)  24 ( 25 ) 4547 - 4551 2022.07

    ISSN  15237060

     View Summary

    Caldorazole (1) was isolated from the marine cyanobacterium Caldora sp. collected on Ishigaki Island, Okinawa, Japan. Its structure was determined to be a new polyketide that contained two thiazole rings and an O-methylenolpyruvamide moiety. Caldorazole (1) showed strong cytotoxicity toward tumor cells that had been seeded at a high density. Cell death induced by 1 in HeLa and A431 cells was also observed only in the presence of the glycolysis blocker 2-deoxy-d-glucose (2DG). Co-treatment with 1 and 2DG remarkably decreased ATP levels in these cells. Furthermore, 1 selectively inhibited complex I in the mitochondrial respiratory chain. Thus, 1 was demonstrated to exert cytotoxicity toward human tumor cells by blocking mitochondrial respiration. 2022 American Chemical Society.

  • Allelopathic Activity of a Novel Compound, 5,6-Dihydrogen-11α-O-acetyl-12β-O-tigloyl-17β-marsdenin, and a Known Steroidal Glycoside from the Leaves of Marsdenia tenacissima (Roxb.) Moon

    Moh S.M., Iwasaki A., Suenaga K., Kato-Noguchi H.

    Agronomy (Agronomy)  12 ( 7 )  2022.07

     View Summary

    Medicinal plants are rich sources of bioactive substances that can be used to develop environmentally friendly weed control alternatives. Marsdenia tenacissima (Roxb.) Moon is a traditional medicinal plant well known for its pharmacological activities and several bioactive compounds. However, its allelopathy and related substances have not been reported. Hence, the present study was conducted to explore the allelopathic potential and substances from M. tenacissima leaves. Aqueous methanol extracts of M. tenacissima showed significant inhibitory activities against the growth of cress (Lepidium sativum L.) and Italian ryegrass (Lolium multiflorum Lam.). The extracts were purified through various chromatography steps, and two allelopathic substances were isolated and determined by spectral data to be steroidal glycoside 1 (5,6-dihydrogen-11α-O-acetyl-12β-O-tigloyl-17β-marsdenin), a novel compound, and steroidal glycoside 2 (5,6-dihydrogen-11α,12β-di-O-tigloyl-17β-marsdenin). Both compounds significantly inhibited the growth of cress seedlings. Steroidal glycoside 1 showed 1.6-and 4-times greater growth inhibitory potential against the cress shoots and roots than steroidal glycoside 2. The concentrations needed for 50% growth inhibition of the cress seedling shoots and roots were 0.46 and 0.03 mM for steroidal glycoside 1, respectively, and 0.74 and 0.12 mM for steroidal glycoside 2, respectively. Therefore, these results suggest that steroidal glycosides 1 and 2 may be responsible for the allelopathy of the M. tenacissima leaves.

  • Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca<sup>2+</sup>-ATPase Inhibitor from the Marine Cyanobacterium Leptochromothrix valpauliae

    Kurisawa N., Iwasaki A., Teranuma K., Dan S., Toyoshima C., Hashimoto M., Suenaga K.

    Journal of the American Chemical Society (Journal of the American Chemical Society)  144 ( 24 ) 11019 - 11032 2022.06

    ISSN  00027863

     View Summary

    Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is a membrane protein on the endoplasmic reticulum (ER) that transports Ca2+ from the cytosol into the ER. As its function is associated with various biological phenomena, SERCA has been recognized as a promising druggable target. Here, we report the second-strongest SERCA-inhibitory compound known to date, which we isolated from the marine cyanobacterium Leptochromothrix valpauliae and named iezoside (1). The structure of iezoside (1) is fundamentally different from that of any other SERCA inhibitor, and its potency is the strongest among marine natural products (Ki 7.1 nM). In this article, we report our comprehensive analysis of iezoside (1), which covers its isolation, structural characterization supported by density functional theory (DFT) calculations and statistical analysis, total synthesis, and clarification of the mode of action of its potent antiproliferative activity (IC50 6.7 ± 0.4 nM against HeLa cells).

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Presentations 【 Display / hide

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 海洋シアノバクテリア由来の熱帯病治療薬リード化合物の創製

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2017.04
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    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

    2016.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Cultivation of Useful Marine Cyanobacteria and Analysis of Biosynthetic genes

    2016.04
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    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Principal investigator

Awards 【 Display / hide

  • The CSJ Award for Young Chemists

    SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • 井上研究奨励賞

    SUENAGA Kiyotake, 1998.02, 井上科学振興財団

    Type of Award: Award from publisher, newspaper, foundation, etc.

 

Courses Taught 【 Display / hide

  • SEMINAR IN CHEMISTRY

    2022

  • ORGANIC STRUCTURAL DETERMINATION

    2022

  • MICROBIOLOGY

    2022

  • LABORATORY IN SCIENCE

    2022

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2022

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Memberships in Academic Societies 【 Display / hide

  • 日本薬学会, 

    2001.04
    -
    Present
  • 有機合成化学協会, 

    1995.04
    -
    Present
  • 日本化学会, 

    1992.04
    -
    Present

Committee Experiences 【 Display / hide

  • 2015.04
    -
    Present

    理事, 私立大学環境保全協議会

  • 2014.04
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    Present

    企画委員, 私立大学環境保全協議会

  • 2013.01
    -
    2013.03

    審査員, 関東地区化学クラブ発表会

  • 2011.11
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    2016.03

    審査員, 文部科学省 サイエンスインカレ

  • 2011.04
    -
    Present

    代表正会員, 日本化学会関東支部

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