Suenaga, Kiyotake

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Professor

Related Websites

External Links
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Career 【 Display / hide 】

  • 1995.03
    -
    1996.03

    名古屋大学理学部助手

  • 1996.04
    -
    2001.03

    名古屋大学大学院理学研究科助手

  • 2001.04
    -
    2003.03

    静岡県立大学薬学部助手

  • 2003.04
    -
    2004.03

    筑波大学化学系講師

  • 2004.04
    -
    2006.03

    筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide 】

  • 1992.03

    Nagoya University, Faculty of Science, Department of Chemistry

    University, Graduated

  • 1995.02

    Nagoya University, 理学研究科, 化学専攻

    Graduate School, Withdrawal before completion, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（理学）, 名古屋大学, Dissertation, 1997.03

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules (Natural Products Chemistry)

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Research Keywords 【 Display / hide 】

  • Total Synthesis

  • Isolation and Structure Determination

  • Mode of Action

  • Marine Cyanobacteria

  • Bioactive Substances

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Books 【 Display / hide 】

  • 天然物化学II—自然からの贈り物—、科学のとびら64

    末永 聖武, 東京化学同人, 2018

    Scope: ビセリングビアサイドの化学

  • 天然物化学—魅力と展望— 科学のとびら60

    末永 聖武, 東京化学同人, 2016

    Scope: ラン藻類の化学

  • Marine Pharmacognosy: Trends and Applications

    Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

    Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

  • ソレル　有機化学

    SUENAGA Kiyotake, 東京化学同人, 2009.12

    Scope: 551-610

  • 天然物化学—海洋生物編

    末永聖武、照屋俊明, アイピーシー, 2008

    Scope: サンゴの生態化学

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Papers 【 Display / hide 】

  • Toxicity of the marine glycosidic macrolides, polycavernoside E and akunolides, from Okinawan cyanobacterium Okeania sp. in mice

    Yotsu-Yamashita M., Umeda K., Iwasaki A., Suenaga K.

    Toxicon 250 2024.11

    ISSN  00410101

    　View Summary

    The toxicity of polycavernoside E and its structurally related macrolides, akunolides A, B, and C, was evaluated in mice. These compounds were recently isolated from the marine cyanobacterium Okeania sp. collected in Okinawa, Japan. The minimal toxicity of polycavernoside E was estimated as 0.81 mg/kg by intraperitoneal injection, whereas those of akunolides A–C were >13 mg/kg. Owing to the considerable toxicity of polycavernoside E, the occurrence of this cyanobacterium should be considered in seaweed production environments.

  • Allelopathic Activity of Leaf Wastes of Liriodendron tulipifera for Sustainable Management

    Kato-Noguchi H., Hayashi K., Iwasaki A., Suenaga K.

    Applied Sciences (Switzerland) 14 ( 18 )  2024.09

    　View Summary

    Logging operations of Liriodendron tulipifera L., as timber trees, and fallen leaves in autumn from ornamental trees produce a large amount of leaf waste. In this study, the allelopathy of L. tulipifera fresh and fallen leaves was investigated for the development of potential applications of leaf waste. The extracts of fresh and fallen leaves of L. tulipifera showed growth inhibitory activity against weed species, Vulpia myuros (L.) C.C.Gmel., Echinochloa crus-galli (L.) P.Beauv., and Lolium multiflorum Lam., under laboratory conditions. The powder of L. tulipifera fresh and fallen leaves also inhibited the germination of E. crus-galli under greenhouse conditions. A potent allelochemical was isolated from fresh and fallen leaf extracts through a bioassay-guided separation process, and was identified as lipiferolide. Lipiferolide inhibited the growth of L. multiflorum and Lepidum sativum in a concentration-dependent manner. This investigation suggests that the leaf waste of L. tulipifera from logging operations and fallen leaves is potentially useful for the purpose of weed control, such as through the use of soil additive materials from leaves or the creation of foliar spray from leaf extracts. The development of weed control materials using L. tulipifera leaf waste may be a means with which to minimize waste, reducing environmental impacts and economic concerns.

  • Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine Moorena sp. Cyanobacterium

    Kurisawa N., Jeelani G., Nozaki T., Agusta A.L., Suenaga K., Iwasaki A.

    Journal of Natural Products 87 ( 7 ) 1838 - 1843 2024.07

    ISSN  01633864

    　View Summary

    Here, we report wajeepeptin (1), a new cyclic depsipeptide isolated from a marine Moorena sp. cyanobacterium. The structure was elucidated by a combination of spectroscopic analyses, X-ray diffraction analysis, and degradation reactions. Wajeepeptin (1) showed moderate cytotoxicity (IC50 = 3.7 μM against HeLa cells) and potent antitrypanosomal activity (IC50 = 0.73 ± 0.14 μM against Trypanosoma brucei rhodesiense).

  • Structure–activity relationship studies on iezoside, a highly potent Ca<sup>2+</sup> ATPase inhibitor

    Kurisawa N., Teranuma K., Noto A., Iwasaki A., Kabashima Y., Nakajima R., Toyoshima C., Suenaga K.

    Bulletin of the Chemical Society of Japan 97 ( 7 )  2024.07

    ISSN  00092673

    　View Summary

    Iezoside (1a) is a novel, potent sarco-/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor from marine cyanobacterium. This paper describes the synthesis of comprehensive iezoside (1a) analogs containing C-18/19 diastereomers, simplified analogs without the peptide unit, and aglycones. Evaluations of the antiproliferative activities against cancer cells and SERCA inhibitory activities of the synthesized analogs revealed how the absolute configurations at C-18/19, peptide, and the sugar unit contribute to each bioactivity.

  • Allelopathy and Allelochemicals in Chamaecyparis obtusa Leaves for the Development of Sustainable Agriculture

    Kato-Noguchi H., Mori K., Iwasaki A., Suenaga K.

    Agronomy 14 ( 7 )  2024.07

    　View Summary

    Chamaecyparis obtusa (Siebold et Zucc.) Endl. is cultivated in the temperate region of East Asia for its high-quality and profitable timber. The timber-processing industry produces a large amount of waste, such as tree bark, branches, and leaves, and finding ways to minimize such waste is economically and environmentally efficient. In the present study, the allelopathic activity and allelochemicals of the C. obtusa leaves were investigated to develop potential application methods. C. obtusa leaves were phytotoxic and associated leaf extracts significantly suppressed the growth of the weeds; Echinochloa crus-galli, Phleum pratense and Lolium multiflorum under laboratory conditions. The leaf powder applied onto the soil surface also suppressed the germination of E. crus-galli and P. pratense under greenhouse conditions. Hinokiic acid and (+)-dihydrosesamin were isolated from the leaves and structurally identified. Both compounds suppressed the growth of cress and P. pratense in a concentration dependent manner. When the leaves of C. obtua were applied as a soil additive, hinokiic acid and (+)-dihydrosesamin in the leaves potentially cause the growth inhibitory activity by leaching into the soil. These experiments showed that the leaves and the leaf extracts of C. obtusa are phytotoxic. These experiments also demonstrated that the leaves and the leaf extracts of C. obtusa have growth inhibitory potential against several plant species, and the leaves produce allelochemicals. Therefore, the leaves and leaf extracts of C. obtusa may be useful for weed suppression purposes. The leaf biomass of C. obtusa is frequently large and the timber processing industry produces significant leaf waste. The development of weed control products using waste leaves may be a solution to minimize the timber processing waste to reduce environmental impact and provide economic value. However, leaf material should be evaluated for weed suppression and herbicidal activity as a soil additive and also possible as a foliar spray under field conditions.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 粟国島産未記載種海洋シアノバクテリア由来Terukufazoline類の単離、構造決定、生物活性および合成研究

    田口黎武、海老原玲、恒松雄太、Ghulam Jeelani、野崎智義、末永聖武、岩崎有紘

    第65回天然有機化合物討論会 (東京大学安田講堂) , 

    2023.09
    , 

    Oral presentation (general)

  • 粟国島産未記載種海洋シアノバクテリア由来Terukufazoline類の単離、構造決定、生物活性および合成研究

    田口黎武、海老原玲、恒松雄太、Ghulam Jeelani、野崎智義、末永聖武、岩崎有紘

    第69回トキシンシンポジウム (京都産業大学) , 

    2023.09
    , 

    Oral presentation (general)

  • 海洋シアノバクテリア由来新規鎖状ペプチド hedoamide の構造と生物活性

    栗澤 尚瑛、岩﨑 有紘、Ghulam Jeelani、Yulia Rahmawati、野崎 智義、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03
    , 

    Oral presentation (general)

  • Biselyngbyaside 人工類縁体の合成研究

    先山 佳寿、岩崎 有紘、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03
    , 

    Oral presentation (general)

  • 海洋シアノバクテリア由来の新規配糖体マクロリドakunolide類の単離及び構造決定

    梅田 海里、岩崎 有紘、末永 聖武

    日本化学会第103春季年会 (東京理科大学野田キャンパス) , 

    2023.03
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 海洋産カルシウムポンプ阻害剤に基づく抗マラリア薬リード化合物の創製

    2024.04
    -
    2028.03

    基盤研究(B), Principal investigator

  • 海洋シアノバクテリア由来の熱帯病治療薬リード化合物の創製

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2017.04
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    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

    2016.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Awards 【 Display / hide 】

  • The CSJ Award for Young Chemists

    SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 井上研究奨励賞

    SUENAGA Kiyotake, 1998.02, 井上科学振興財団

    Type of Award： Award from publisher, newspaper, foundation, etc.

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Courses Taught 【 Display / hide 】

  • SEMINAR IN CHEMISTRY

    2024

  • ORGANIC STRUCTURAL DETERMINATION

    2024

  • MICROBIOLOGY

    2024

  • LABORATORY IN SCIENCE

    2024

  • LABORATORIES IN CHEMISTRY 2

    2024

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Memberships in Academic Societies 【 Display / hide 】

  • 日本薬学会, 

    2001.04
    -
    Present

  • 有機合成化学協会, 

    1995.04
    -
    Present

  • 日本化学会, 

    1992.04
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2023.04
    -
    Present

    世話人, 天然有機化合物討論会

  • 2023.03
    -
    Present

    副会長, 私立大学環境保全協議会

  • 2015.04
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    Present

    理事, 私立大学環境保全協議会

  • 2014.04
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    Present

    企画委員, 私立大学環境保全協議会

  • 2013.01
    -
    2013.03

    審査員, 関東地区化学クラブ発表会

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