Suenaga, Kiyotake

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Professor

Related Websites

External Links
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Career 【 Display / hide 】

  • 1995.03
    -
    1996.03

    名古屋大学理学部助手

  • 1996.04
    -
    2001.03

    名古屋大学大学院理学研究科助手

  • 2001.04
    -
    2003.03

    静岡県立大学薬学部助手

  • 2003.04
    -
    2004.03

    筑波大学化学系講師

  • 2004.04
    -
    2006.03

    筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide 】

  • 1992.03

    Nagoya University, Faculty of Science, Department of Chemistry

    University, Graduated

  • 1995.02

    Nagoya University, 理学研究科, 化学専攻

    Graduate School, Withdrawal before completion, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（理学）, 名古屋大学, Dissertation, 1997.03

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules (Natural Products Chemistry)

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Research Keywords 【 Display / hide 】

  • Total Synthesis

  • Isolation and Structure Determination

  • Mode of Action

  • Marine Cyanobacteria

  • Bioactive Substances

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Books 【 Display / hide 】

  • 天然物化学II—自然からの贈り物—、科学のとびら64

    末永 聖武, 東京化学同人, 2018

    Scope: ビセリングビアサイドの化学

  • 天然物化学—魅力と展望— 科学のとびら60

    末永 聖武, 東京化学同人, 2016

    Scope: ラン藻類の化学

  • Marine Pharmacognosy: Trends and Applications

    Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

    Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

  • ソレル　有機化学

    SUENAGA Kiyotake, 東京化学同人, 2009.12

    Scope: 551-610

  • 天然物化学—海洋生物編

    末永聖武、照屋俊明, アイピーシー, 2008

    Scope: サンゴの生態化学

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Papers 【 Display / hide 】

  • Isolation and Total Synthesis of Ukabamide, an Antitrypanosomal Lipopeptide from a Marine Moorena sp. Cyanobacterium

    Hagihara M., Kurisawa N., Iwasaki A., Taguchi R., Jeelani G., Nozaki T., Suenaga K.

    Organic Letters  2025

    ISSN  15237060

    　View Summary

    Human African trypanosomiasis (HAT) is one of the most lethal of the neglected tropical diseases. While the discovery of a novel antitrypanosomal drug is highly desired, the creation of a superior lead compound is challenging. Herein we report ukabamide (1), which was isolated from a marine Moorena sp. cyanobacterium, as a selective and potent antitrypanosomal lipopeptide (IC50 = 34 ± 18 nM against Trypanosoma brucei rhodesiense). Its structure was elucidated by spectroscopic analyses and degradation reactions and confirmed by total synthesis. In addition, we prepared two modified analogs and revealed the importance of the fatty acid chain length for biological activity. These findings may provide design guidelines for an antitrypanosomal drug.

  • Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium Okeania sp.

    Tojo S., Natsume N., Niino T., Iwasaki A., Suenaga K., Ohno O., Teruya T.

    Journal of Natural Products  2025

    ISSN  01633864

    　View Summary

    A novel 19-membered cyclic depsipeptide, hedopeptolide (1), was isolated from Okeania sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide (1) inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

  • Sealgamide: An Antitrypanosomal Lipopeptide Isolated from a Marine Okeania sp. Cyanobacterium

    Wakai K., Kurisawa N., Umeda K., Jeelani G., Agusta A.L., Nozaki T., Suenaga K.

    Journal of Natural Products  2025

    ISSN  01633864

    　View Summary

    Sealgamide (1), a new antitrypanosomal lipopeptide, was isolated from a marine Okeania sp. cyanobacterium. Elucidation of its structure was challenging due to signal overlap caused by conspicuous rotamers but was ultimately achieved through partial hydrolysis and subsequent spectroscopic analyses. Sealgamide (1) exhibited moderate antitrypanosomal activity against Trypanosoma brucei rhodesiense (IC50 2.9 μM) while showing no antimalarial activity (IC50 > 25 μM) or cytotoxicity (IC50 > 30 μM). Furthermore, we discovered that an artificial C-terminal methyl ester analogue (2) exhibited notably enhanced antiparasitic activity.

  • Toxicity of the marine glycosidic macrolides, polycavernoside E and akunolides, from Okinawan cyanobacterium Okeania sp. in mice

    Yotsu-Yamashita M., Umeda K., Iwasaki A., Suenaga K.

    Toxicon 250 2024.11

    ISSN  00410101

    　View Summary

    The toxicity of polycavernoside E and its structurally related macrolides, akunolides A, B, and C, was evaluated in mice. These compounds were recently isolated from the marine cyanobacterium Okeania sp. collected in Okinawa, Japan. The minimal toxicity of polycavernoside E was estimated as 0.81 mg/kg by intraperitoneal injection, whereas those of akunolides A–C were >13 mg/kg. Owing to the considerable toxicity of polycavernoside E, the occurrence of this cyanobacterium should be considered in seaweed production environments.

  • The Bioorganic Study of Iezoside: A Novel SERCA Inhibitor from the Marine Cyanobacterium

    Kurisawa N., Iwasaki A., Suenaga K.

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 82 ( 11 ) 1107 - 1116 2024.11

    ISSN  00379980

    　View Summary

    In this era of advanced technologies, is there still wisdom to be gleaned from nature? The answer is an unequivocal “Yes”. Discovering new natural products from nature, determining their structures, and revealing their biological activities ‐ this classical natural product chemistry is still a catalyst for innovation in a wide range of fields, including the expansion of chemical space, elucidation of life phenomena, and drug discovery. In this account, we describe a comprehensive bioorganic study of iezoside (1a), the novel marine natural product we recently discovered, including its discovery, synthesis, mode of action, and structure‐activity relationships.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 強力な小胞体カルシウムポンプ阻害剤 iezoside の光親和性プローブ合成および結合部位の解析

    能登明佳理、栗澤尚瑛、末永聖武

    日本化学会第105春季年会 (関西大学千里山キャンパス) , 

    2025.03
    , 

    Oral presentation (general)

  • 未同定海洋シアノバクテリア由来、Kagimmicin の全合成研究

    古川惇晟、栗澤尚瑛、末永聖武

    日本化学会第105春季年会 (関西大学千里山キャンパス) , 

    2025.03
    , 

    Oral presentation (general)

  • 沖縄県産海洋シアノバクテリア由来新規鎖状リポペプチドsealgamideの全合成研究

    土屋麻乃、若井和樹、栗澤尚瑛、末永聖武

    日本化学会第105春季年会 (関西大学千里山キャンパス) , 

    2025.03
    , 

    Oral presentation (general)

  • 海洋シアノバクテリア由来新規リポペプチド taketamines A-C の単離と構造決定

    若井和樹、栗澤尚瑛、梅田海里、末永聖武

    日本化学会第105春季年会 (関西大学千里山キャンパス) , 

    2025.03
    , 

    Oral presentation (general)

  • 未同定海洋シアノバクテリア由来新規環状デプシペプチド Shimojilide の単離および構造決定

    仁井山瑞歩、栗澤尚瑛、末永聖武

    日本化学会第105春季年会 (関西大学千里山キャンパス) , 

    2025.03
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 海洋産カルシウムポンプ阻害剤に基づく抗マラリア薬リード化合物の創製

    2024.04
    -
    2028.03

    基盤研究(B), Principal investigator

  • 海洋シアノバクテリア由来の熱帯病治療薬リード化合物の創製

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2017.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

    2016.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Awards 【 Display / hide 】

  • The CSJ Award for Young Chemists

    SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 井上研究奨励賞

    SUENAGA Kiyotake, 1998.02, 井上科学振興財団

    Type of Award： Award from publisher, newspaper, foundation, etc.

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Courses Taught 【 Display / hide 】

  • TOPICS IN BIOORGANIC CHEMISTRY

    2025

  • SEMINAR IN CHEMISTRY

    2025

  • ORGANIC STRUCTURAL DETERMINATION

    2025

  • MICROBIOLOGY

    2025

  • LABORATORY IN SCIENCE

    2025

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Memberships in Academic Societies 【 Display / hide 】

  • 日本薬学会, 

    2001.04
    -
    Present

  • 有機合成化学協会, 

    1995.04
    -
    Present

  • 日本化学会, 

    1992.04
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2023.04
    -
    Present

    世話人, 天然有機化合物討論会

  • 2023.03
    -
    Present

    副会長, 私立大学環境保全協議会

  • 2015.04
    -
    Present

    理事, 私立大学環境保全協議会

  • 2014.04
    -
    Present

    企画委員, 私立大学環境保全協議会

  • 2013.01
    -
    2013.03

    審査員, 関東地区化学クラブ発表会

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