Suenaga, Kiyotake

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Professor

E-mail Address

E-mail address

Related Websites

External Links

Career 【 Display / hide

  • 1995.03
    -
    1996.03

    名古屋大学理学部助手

  • 1996.04
    -
    2001.03

    名古屋大学大学院理学研究科助手

  • 2001.04
    -
    2003.03

    静岡県立大学薬学部助手

  • 2003.04
    -
    2004.03

    筑波大学化学系講師

  • 2004.04
    -
    2006.03

    筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide

  • 1992.03

    Nagoya University, Faculty of Science, Department of Chemistry

    University, Graduated

  • 1995.02

    Nagoya University, 理学研究科, 化学専攻

    Graduate School, Withdrawal before completion, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(理学), 名古屋大学, Dissertation, 1997.03

 

Research Areas 【 Display / hide

  • Biomolecular chemistry (Natural Products Chemistry)

Research Keywords 【 Display / hide

  • Total Synthesis

  • Isolation and Structure Determination

  • Mode of Action

  • Marine Cyanobacteria

  • Bioactive Substances

 

Books 【 Display / hide

  • 天然物化学II—自然からの贈り物—、科学のとびら64

    末永 聖武, 東京化学同人, 2018

    Scope: ビセリングビアサイドの化学

  • 天然物化学—魅力と展望— 科学のとびら60

    末永 聖武, 東京化学同人, 2016

    Scope: ラン藻類の化学

  • Marine Pharmacognosy: Trends and Applications

    Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

    Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

  • ソレル 有機化学

    SUENAGA Kiyotake, 東京化学同人, 2009.12

    Scope: 551-610

  • 天然物化学—海洋生物編

    末永聖武、照屋俊明, アイピーシー, 2008

    Scope: サンゴの生態化学

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Papers 【 Display / hide

  • Irijimasides A-E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium

    Yamano A., Natsume N., Yamada M., Sumimoto S., Iwasaki A., Suenaga K., Teruya T.

    Journal of Natural Products (Journal of Natural Products)  83 ( 5 ) 1585 - 1591 2020.05

    ISSN  01633864

     View Summary

    Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. Irijimasides A-E (1-5), a series of new 14-membered macrolide glycosides, were isolated from a marine cyanobacterium collected in Okinawa. The gross structures of 1-5 were established by spectroscopic analysis, including 2D NMR, while absolute stereostructures were determined based on NOESY spectra, chemical derivatization, and ECD data. All five macrolides suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity in mouse RAW264 macrophage cells, indicating that these compounds inhibit osteoclast formation.

  • Iheyamides A-C, Antitrypanosomal Linear Peptides Isolated from a Marine Dapis sp. Cyanobacterium

    Kurisawa N., Iwasaki A., Jeelani G., Nozaki T., Suenaga K.

    Journal of Natural Products (Journal of Natural Products)  83 ( 5 ) 1684 - 1690 2020.05

    ISSN  01633864

     View Summary

    © 2020 American Chemical Society and American Society of Pharmacognosy. Iheyamides A (1), B (2), and C (3), new linear peptides, were isolated from a marine Dapis sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Iheyamide A (1) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense and Trypanosoma brucei brucei (IC50 = 1.5 μM), but the other two analogues, iheyamides B (2) and C (3), did not (IC50 > 20 μM, respectively). The structure-activity relationship clarified that an isopropyl-O-Me-pyrrolinone moiety was necessary for the antitrypanosomal activity. Furthermore, the cytotoxicity of 1 against normal human cells, WI-38, was 10 times weaker than its antitrypanosomal activity (IC50 = 18 μM).

  • A kaurene-type novel phytotoxic substance in Wedelia chinensis

    Rany Das K., Iwasaki A., Suenaga K., Kato-Noguchi H.

    Tetrahedron Letters (Tetrahedron Letters)  61 ( 11 )  2020.03

    ISSN  00404039

     View Summary

    © 2020 Elsevier Ltd Wedelia chinensis has been widely used as a traditional medicine and several bioactive compounds have been isolated. We investigated phytotoxic property and phytotoxic substances in the species. An aqueous methanol extract of W. chinensis inhibited the growth of roots and shoots of cress. The extracts were then purified by several chromatographic runs with monitoring the inhibitory activity and a phytotoxic substance was isolated. The substance was determined by spectral data to be a novel kaurene-type compound, wedelienone. Wedelienone inhibited the growth of cress and timothy (Phleum pratense L) at concentrations greater than 10–30 μM. These results suggest that wedelienone may contribute to the phytotoxic effects caused by the extracts.

  • Isolation and identification of two phytotoxic compounds from the medicinal plant Cassia alata L.

    Das K.R., Iwasaki K., Suenaga K., Kato-Noguchi H.

    Weed Biology and Management (Weed Biology and Management)  20 ( 1 ) 3 - 11 2020.03

    ISSN  14446162

     View Summary

    © 2020 Weed Science Society of Japan Cassia alata (Caesalpiniaceae), an ornamental shrub, has many biological properties such as antifungal and antibacterial activities. Several bioactive and phytotoxic compounds have already been isolated from C. alata. Phytotoxic substances from plants have drawn attention as an alternative biological approach to control weeds. Thus, we conducted this research to explore other phytotoxic compounds in C. alata leaves. Aqueous methanol extracts of C. alata leaves strongly inhibited the seedling growth of broccoli, cabbage, cress, radish and rapeseed, in which the level of inhibition correlated with concentration. Two active compounds were isolated through chromatographies and identified using spectral data as (S)-4-(3-hydroxybutyl)phenol [(+)-rhododendrol] and (E)-4-((1R,4R)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one [3-hydroxy-α-ionone]. These two active compounds inhibited the growth of cress seedlings in a concentration-dependent manner. The required concentrations for 50% growth inhibition (I50 value) of cress seedlings were 192.0–296.1 μM for (+)-rhododendrol and 132.4–195.3 μM for 3-hydroxy-α-ionone. These results indicate that the two phytotoxic compounds play a part in the phytotoxic activity of C. alata leaves.

  • Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium

    Iwasaki K., Iwasaki A., Sumimoto S., Matsubara T., Sato T., Nozaki T., Saito-Nakano Y., Suenaga K.

    Journal of Natural Products (Journal of Natural Products)  83 ( 2 ) 481 - 488 2020.02

    ISSN  01633864

     View Summary

    Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • Bioactive Marine Macrolides from Marine Cyanobacteria.

    Maho Morita, Eisuke Sato, Osamu Ohno, and Kiyotake Suenaga

    The 4th Joint Conference Keio & Kaohsiung Medical University (National Museum of Marine Biology and Aquarium, 台湾) , 2019.09, Oral Presentation(guest/special)

  • 強力な抗トリパノソーマ活性を示す海洋天然物hoshinolactam類の単離、構造決定、 全合成と生物活性

    岩崎有紘、小川英俊、澄本慎平、鄭丞宰、岩月正人、石山亜紀、穂刈玲、乙黒一彦、大村智、中野由美子、野崎智義、末永聖武

    第61回天然有機化合物討論会 (広島国際会議場) , 2019.09, Oral Presentation(general)

  • 海洋シアノバクテリア由来マクロリドの構造決定、生物活性、全合成

    末永聖武

    (横浜薬科大学) , 2019.06, Oral Presentation(guest/special)

  • 海洋天然物 jahanyne 類の全合成および結合タンパク質の同定

    保科静香、岩﨑有紘、藤村遥、岡本慎一朗、工藤隆文、照屋俊明、末永聖武

    日本ケミカルバイオロジー学会第14回年会 (ウインクあいち(名古屋市)) , 2019.06, Poster (general)

  • 海洋シアノバクテリア由来鎖状リポペプチドMinnamide Aの単離、構造決定および生物活性

    澄本慎平、小林正幸、佐藤理央、四宮誠一、岩﨑有紘、須田彰一郎、照屋俊明、犬塚俊康、大野修、末永聖武

    日本ケミカルバイオロジー学会第14回年会 (ウインクあいち(名古屋市)) , 2019.06, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

  • 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

    2017.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

  • カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

    2016.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • Cultivation of Useful Marine Cyanobacteria and Analysis of Biosynthetic genes

    2016.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 末永 聖武, Grant-in-Aid for Challenging Exploratory Research, Principal Investigator

Awards 【 Display / hide

  • The CSJ Award for Young Chemists

    SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

    Type of Award: Awards of National Conference, Council and Symposium

  • 井上研究奨励賞

    SUENAGA Kiyotake, 1998.02, 井上科学振興財団

    Type of Award: Awards of Publisher, Newspaper Company and Foundation

 

Courses Taught 【 Display / hide

  • SEMINAR IN CHEMISTRY

    2020

  • ORGANIC STRUCTURAL DETERMINATION

    2020

  • LABORATORY IN SCIENCE

    2020

  • LABORATORIES IN CHEMISTRY 2

    2020

  • INSTRUMENTAL ANALYSIS OF BIOMOLECULES

    2020

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Memberships in Academic Societies 【 Display / hide

  • 日本薬学会, 

    2001.04
    -
    Present
  • 有機合成化学協会, 

    1995.04
    -
    Present
  • 日本化学会, 

    1992.04
    -
    Present

Committee Experiences 【 Display / hide

  • 2015.04
    -
    Present

    理事, 私立大学環境保全協議会

  • 2014.04
    -
    Present

    企画委員, 私立大学環境保全協議会

  • 2013.01
    -
    2013.03

    審査員, 関東地区化学クラブ発表会

  • 2011.11
    -
    2016.03

    審査員, 文部科学省 サイエンスインカレ

  • 2011.04
    -
    Present

    代表正会員, 日本化学会関東支部

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