KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1995.03

  -

  1996.03

  名古屋大学理学部助手

• 1996.04

  -

  2001.03

  名古屋大学大学院理学研究科助手

• 2001.04

  -

  2003.03

  静岡県立大学薬学部助手

• 2003.04

  -

  2004.03

  筑波大学化学系講師

• 2004.04

  -

  2006.03

  筑波大学大学院数理物質科学研究科講師

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1992.03

  Nagoya University, Faculty of Science, Department of Chemistry

  University, Graduated

• 1995.02

  Nagoya University, 理学研究科, 化学専攻

  Graduate School, Withdrawal before completion, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（理学）, 名古屋大学, Dissertation, 1997.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules (Natural Products Chemistry)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Total Synthesis

• Isolation and Structure Determination

• Mode of Action

• Marine Cyanobacteria

• Bioactive Substances

Books 【 Display / hide 】

Books 【 Display / hide 】

• 天然物化学II—自然からの贈り物—、科学のとびら64

  末永 聖武, 東京化学同人, 2018

  Scope: ビセリングビアサイドの化学

• 天然物化学—魅力と展望— 科学のとびら60

  末永 聖武, 東京化学同人, 2016

  Scope: ラン藻類の化学

• Marine Pharmacognosy: Trends and Applications

  Toshiaki Teruya, Osamu Ohno, Kiyotake Suenaga, CRC Press, 2012.12

  Scope: Bioactive Compounds from Okinawan Marine Cyanobacteria.

• ソレル　有機化学

  SUENAGA Kiyotake, 東京化学同人, 2009.12

  Scope: 551-610

• 天然物化学—海洋生物編

  末永聖武、照屋俊明, アイピーシー, 2008

  Scope: サンゴの生態化学

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Shimojilide, a Potent and Selective Antiproliferative Cyclic Lipopeptide from a Marine Cyanobacterium Okeania sp.

  Niiyama M., Kurisawa N., Dan S., Suenaga K.

  Organic Letters 28 ( 5 ) 1810 - 1814 2026.02

  ISSN  15237060

  　View Summary

  Shimojilide (1), a new cyclic lipopeptide, was isolated from a marine cyanobacterium Okeania sp. Its structure was elucidated by NMR and chemical derivatization, revealing a peptide–polyketide hybrid with a skipped diene and β-branched methyl group. Shimojilide (1) exhibited potent and selective antiproliferative activity with a unique JFCR39 fingerprint that poorly correlates with those of known anticancer agents, suggesting a distinct mechanism of action. Shimojilide (1) represents a promising lead for anticancer drug discovery.

  • Access to Document (DOI)

• Zampamide: A lipopeptide isolated from Caldora sp. marine cyanobacterium

  Tojo S., Ozaki K., Natsume N., Kurisawa N., Suenaga K., Teruya T.

  Tetrahedron 188 2025.12

  ISSN  00404020

  　View Summary

  Overweight and obesity are pathological conditions characterized by the accumulation of excessive fat. Adipokines, which are secreted by hypertrophied adipocytes, are known to increase the risk of various diseases. Therefore, identifying compounds that promote lipolysis in adipocytes is a promising way to prevent hypertrophy of these cells. Although numerous bioactive compounds have been isolated from marine cyanobacteria, reports on compounds exhibiting such activity remain limited. In this study, we report the discovery of zampamide (1), a linear lipopeptide that stimulates lipolysis in 3T3-L1 adipocytes. It was isolated from a marine cyanobacterium of the genus Caldora collected in Okinawa, Japan. The planar structure of 1 was elucidated primarily using two-dimensional NMR and mass spectrometry. The absolute configurations of the amino acid residues in 1 were determined after acid hydrolysis, followed by Marfey's analysis of the resulting hydrolysates. Additionally, the absolute configuration of the fatty acid moiety was determined by derivatization. Zampamide (1) increased the amount of free glycerol in a dose-dependent manner, demonstrating its lipolysis-promoting activity. These findings suggest that marine cyanobacteria are a valuable source of novel lipolysis-promoting agents for obese and overweight patients.

  • Access to Document (DOI)

• Bisezakiamides A and B, cyclic depsipeptides from a marine cyanobacterium Nunduva sp.

  Yagisawa K., Natsume N., Watanabe N., Iwasaki A., Suenaga K., Teruya T.

  Tetrahedron 184 2025.10

  ISSN  00404020

  　View Summary

  Two cyclic peptides, bisezakiamides A (1) and B (2), were isolated from a marine cyanobacterium from the coastal waters of Okinawa, Japan. Both compounds contain an α-hydroxy acid residue and a β-amino acid. The structures of 1 and 2 were elucidated by detailed spectroscopic analyses, including various two-dimensional NMR techniques and application of Marfey's analysis. Both compounds exhibited growth-inhibitory activity against HeLa S3 cells, with IC<inf>50</inf> values of 8.7 and 5.8 μM for compounds 1 and 2, respectively.

  • Access to Document (DOI)

• Isolation and Computer-Based Structural Determination of Madangolide B

  Hagihara M., Mehjabin J.J., Vairappan C.S., Okino T., Suenaga K., Iwasaki A.

  Organic Letters 27 ( 25 ) 6807 - 6811 2025.06

  ISSN  15237060

  　View Summary

  Madangolide (1) is a 17-membered cyclic enamide isolated from the marine cyanobacterium Lyngbya bouillonii. Since its discovery in 1999, the relative and absolute configurations of 1 have remained unknown. Here, we report the isolation, structural determination, and biological activity of a new analog of madangolide (1), madangolide B (2), from a marine Moorena sp. cyanobacterium. The planar structure of 2 was established using conventional two-dimensional NMR spectroscopy. The absolute configuration was clarified by comparing the experimental and theoretical data, including the chemical shifts, homonuclear and heteronuclear coupling constants, and ECD spectra. Based on the similarity of the NMR data, we proposed an absolute configuration of madangolide (1) and verified it through degradation and derivatization reactions. This study demonstrates the effectiveness of modern computational chemistry in revealing the stereochemistry of complex natural products with conformational flexibility.

  • Access to Document (DOI)

• Ouhanamide, an Antiparasitic Linear Lipopeptide from a Marine Okeania sp. Cyanobacterium

  Niiyama M., Kurisawa N., Umeda K., Jeelani G., Agusta A.L., Nozaki T., Suenaga K.

  Journal of Natural Products 88 ( 6 ) 1360 - 1368 2025.06

  ISSN  01633864

  　View Summary

  Ouhanamide (1), a new linear lipopeptide consisting of a long-chain fatty acid with a β-branched methyl group, was isolated from a marine Okeania sp. cyanobacterium. The overall structure was elucidated by a combination of various spectroscopic analyses, degradation reactions, and derivatizations. Ouhanamide (1) showed selective antiparasitic activity (IC<inf>50</inf> = 1.2 ± 0.1 μM against Trypanosoma brucei rhodesiense and IC<inf>50</inf> = 4.2 ± 0.9 μM against Plasmodium falciparum) without cytotoxicity at 10 μM against HeLa cells.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Discovery of lead compounds for the treatment of tropical diseases from marine cyanobacteria

  Suenaga, Kiyotake

  科学研究費補助金研究成果報告書 2023

• Development of osteoclast differentiation inhibitors based on marine natural products that act on calcium pumps

  Suenaga, Kiyotake

  科学研究費補助金研究成果報告書 2019

• Cultivation of useful marine cyanobacteria and analysis of biosynthetic genes

  Suenaga, Kiyotake

  科学研究費補助金研究成果報告書 2017

• Bioactive substances from marine cyanobacteria

  Suenaga, Kiyotake

  科学研究費補助金研究成果報告書 2014

• The functional analyses of new macrolides isolated from marine cyanobacteria

  Suenaga, Kiyotake

  科学研究費補助金研究成果報告書 2014

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Erratum: Iheyamides A-C, Antitrypanosomal Linear Peptides Isolated from a MarineDapissp. Cyanobacterium (J. Nat. Prod. (2020) 83: 5 (1684-1690) DOI: 10.1021/acs.jnatprod.0c00250)

  Kurisawa N., Iwasaki A., Jeelani G., Nozaki T., Suenaga K.

  Journal of Natural Products (Journal of Natural Products)  84 ( 4 )  2021.04

  ISSN  01633864

  　View Summary

  Page 1684: The structures of iheyamides A (1), B (2), and C (3) were drawn incorrectly. The configuration at the β position of Ile was inversely depicted in the original paper. The correct structures of iheyamides are as shown below. The authors sincerely apologize for any inconvenience.

  • Access to Document (DOI)

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 強力な小胞体カルシウムポンプ阻害剤 iezoside の光親和性プローブ合成および結合部位の解析

  能登明佳理、栗澤尚瑛、末永聖武

  [Domestic presentation]  日本化学会第105春季年会 (関西大学千里山キャンパス) , 

  2025.03

  , 

  Oral presentation (general)

• 未同定海洋シアノバクテリア由来、Kagimmicin の全合成研究

  古川惇晟、栗澤尚瑛、末永聖武

  [Domestic presentation]  日本化学会第105春季年会 (関西大学千里山キャンパス) , 

  2025.03

  , 

  Oral presentation (general)

• 沖縄県産海洋シアノバクテリア由来新規鎖状リポペプチドsealgamideの全合成研究

  土屋麻乃、若井和樹、栗澤尚瑛、末永聖武

  [Domestic presentation]  日本化学会第105春季年会 (関西大学千里山キャンパス) , 

  2025.03

  , 

  Oral presentation (general)

• 海洋シアノバクテリア由来新規リポペプチド taketamines A-C の単離と構造決定

  若井和樹、栗澤尚瑛、梅田海里、末永聖武

  [Domestic presentation]  日本化学会第105春季年会 (関西大学千里山キャンパス) , 

  2025.03

  , 

  Oral presentation (general)

• 未同定海洋シアノバクテリア由来新規環状デプシペプチド Shimojilide の単離および構造決定

  仁井山瑞歩、栗澤尚瑛、末永聖武

  [Domestic presentation]  日本化学会第105春季年会 (関西大学千里山キャンパス) , 

  2025.03

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 海洋産カルシウムポンプ阻害剤に基づく抗マラリア薬リード化合物の創製

  2024.04

  -

  2028.03

  基盤研究(B), Principal investigator

• 海洋シアノバクテリア由来の熱帯病治療薬リード化合物の創製

  2020.04

  -

  2024.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

• 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

  2019.06

  -

  2021.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

• 特異な化学構造をもつ海洋産リポペプチドの生合成機構解明に基づく人工誘導体生産

  2017.04

  -

  2019.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

• カルシウムポンプに作用する海洋天然物を基盤とした破骨細胞分化抑制剤の創製

  2016.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• The CSJ Award for Young Chemists

  SUENAGA Kiyotake, 2003.03, 日本化学会, Bioorganic Studies on Marine Natural Products with Bioactivities Such As Antitumor Activity and Feeding Attractance

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 井上研究奨励賞

  SUENAGA Kiyotake, 1998.02, 井上科学振興財団

  Type of Award： Award from publisher, newspaper, foundation, etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• TOPICS IN BIOORGANIC CHEMISTRY

  2025

• SEMINAR IN CHEMISTRY

  2025

• ORGANIC STRUCTURAL DETERMINATION

  2025

• MICROBIOLOGY

  2025

• LABORATORY IN SCIENCE

  2025

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本薬学会, 

  2001.04

  -

  Present

• 有機合成化学協会, 

  1995.04

  -

  Present

• 日本化学会, 

  1992.04

  -

  Present

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2023.04

  -

  Present

  世話人, 天然有機化合物討論会

• 2023.03

  -

  Present

  副会長, 私立大学環境保全協議会

• 2015.04

  -

  Present

  理事, 私立大学環境保全協議会

• 2014.04

  -

  Present

  企画委員, 私立大学環境保全協議会

• 2013.01

  -

  2013.03

  審査員, 関東地区化学クラブ発表会

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