KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2004.10

  -

  2006.03

  東京大学大学院工学系研究科　産学官連携研究員

• 2006.04

  -

  2007.03

  日本学術振興会　特別研究員PD

• 2007.04

  -

  2010.03

  慶應義塾大学理工学部化学科　助教

• 2010.04

  -

  2017.03

  慶應義塾大学理工学部化学科　専任講師

• 2017.04

  -

  Present

  慶應義塾大学理工学部化学科　准教授

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1998.03

  The University of Tokyo, Faculty of Engineering, Department of Chemistry and Biotechnology

  University, Graduated

• 2000.03

  The University of Tokyo, Graduate School of Engineering, Department of Chemistry and Biotechnology

  Graduate School, Completed, Master's course

• 2004.09

  University of California, Berkeley, Department of Chemistry

  U.S.A., Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Ph.D., University of California, Berkeley, Coursework, 2004.12

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Synthetic chemistry (Synthetic Chemistry)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Homogeneous Catalysis

• Synthetic Organic Chemistry

• Organometallic Chemistry

• Transition Metal Complexes

• Polymer Synthesis

Books 【 Display / hide 】

Books 【 Display / hide 】

• ハートウィグ有機遷移金属化学（翻訳）

  小宮三四郎、穐田宗隆、岩澤伸治（監訳）、穐田宗隆、石井洋一、伊藤肇、岩澤伸治、上野圭司、大江浩一、河内 卓彌、小宮三四郎、近藤輝幸、中尾佳亮、西原康師、水田勉（共訳）, 東京化学同人, 2015.03

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Selective Monoarylation of Aromatic Ketones via C-H Bond Cleavage by Trialkylphosphine Ruthenium Catalysts

  Suzuki I., Kondo H., Kochi T., Kakiuchi F.

  Journal of Organic Chemistry （Journal of Organic Chemistry)   2019

  ISSN  00223263

  　View Summary

  © 2019 American Chemical Society. A catalyst system consisting of RuHCl(CO)(PiPr3)2, CsF, and a styrene derivative was found to be applicable to selective monoarylation of aromatic ketones via ortho C-H bond cleavage. The reaction of 2′-methoxyacetophenone with arylboronates gave C-H arylation products without cleaving the ortho C-O bond. Acetophenone was also converted to monoarylation products with high selectivity. Cyclohexanone was found to be an effective solvent for the C-H arylation using the catalyst system.

  • Access to Document (DOI)

• Nondissociative chain walking as a strategy in catalytic organic synthesis

  Kochi T., Kanno S., Kakiuchi F.

  Tetrahedron Letters （Tetrahedron Letters)  60 （ 37 ）  2019.09

  ISSN  00404039

  　View Summary

  © 2019 Elsevier Ltd “Nondissociative” chain walking is a mechanism where an alkylmetal species undergoes rapid β-hydride elimination and reinsertion to move the metal center along the alkyl chain without dissociating an alkene intermediate during the migration process. This digest summarizes the unique characteristics of the nondissociative chain walking mechanism compared to the stepwise alkene isomerization mechanism and their use in catalytic organic synthesis.

  • Access to Document (DOI)

• Iron-Catalyzed Ortho-Selective C−H Alkylation of Aromatic Ketones with N-Alkenylindoles and Partial Indolylation via 1,4-Iron Migration

  Kimura N., Kochi T., Kakiuchi F.

  Asian Journal of Organic Chemistry （Asian Journal of Organic Chemistry)  8 （ 7 ） 1115 - 1117 2019.07

  ISSN  21935807

  　View Summary

  © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An ortho-selective C−H alkylation of aromatic ketones with N-alkenylindoles proceeded in the presence of just a Fe(PMe3)4 catalyst. In addition, C−H indolylation products, which are considered to be formed via 1,4-iron migration, were also observed as minor products.

  • Access to Document (DOI)

• Synthesis of N-Arylpyrazoles by Palladium-Catalyzed Coupling of Aryl Triflates with Pyrazole Derivatives

  Onodera S., Kochi T., Kakiuchi F.

  Journal of Organic Chemistry （Journal of Organic Chemistry)  84 （ 10 ） 6508 - 6515 2019.05

  ISSN  00223263

  　View Summary

  © 2019 American Chemical Society. A method for the synthesis of N-arylpyrazoles by palladium-catalyzed coupling of aryl triflates with pyrazole derivatives is described. Using tBuBrettPhos as a ligand, the palladium-catalyzed C-N coupling of a variety of aryl triflates including ortho-substituted ones with pyrazole derivatives proceeded efficiently to give N-arylpyrazole products in high yields. 3-Trimethylsilylpyrazole was found to be an excellent pyrazole substrate for the coupling, and the corresponding product, 1-aryl-3-trimethylsilylpyrazole, also served as a great template for the syntheses of N-arylpyrazole derivatives, as demonstrated by regioselective halogenation at the 3-, 4-, and 5-positions of the pyrazole ring.

  • Access to Document (DOI)

• Metal-Catalyzed Sequential Formation of Distant Bonds in Organic Molecules: Palladium-Catalyzed Hydrosilylation/Cyclization of 1,n-Dienes by Chain Walking

  Kochi T., Ichinose K., Shigekane M., Hamasaki T., Kakiuchi F.

  Angewandte Chemie - International Edition （Angewandte Chemie - International Edition)  58 （ 16 ） 5261 - 5265 2019.04

  ISSN  14337851

  　View Summary

  © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Sequential formation of distant bonds in organic molecules was achieved for the palladium-catalyzed hydrosilylation/cyclization of various 1,n-dienes by chain walking of the metal catalyst. The reaction was applicable to various 1,n-dienes, including a 1,13-diene, to form a cyclopentane ring as well as a carbon–silicon bond at a remote site. The use of “nondissociative” chain walking provides a fascinating strategy in organic synthesis to functionalize distant parts of organic molecules, in a particular order, within a catalytic cycle by effectively moving the reactive center from a remote position.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Development of new methods for catalytic organic synthesis via chain walking

  Kochi, Takuya

  科学研究費補助金研究成果報告書 2016

• Development of catalytic reactions involving late transition-metal vinylidene species bearing hard ligands

  Kochi, Takuya

  科学研究費補助金研究成果報告書 2015

• Development of Innovative Cycloisomerization of Dienes via Chain Walking

  Kochi, Takuya

  科学研究費補助金研究成果報告書 2014

• Development of convenient synthesis of multi-substituted conjugated aromatic compounds by means of carbon-hydrogen and carbon-oxygen bonds cleavage

  Kochi, Takuya

  科学研究費補助金研究成果報告書 2011

• Development of new acylation reactions via aromatic carbon-hydrogen bond cleavaege by transition metal catalysts

  Kochi, Takuya

  科学研究費補助金研究成果報告書 2011

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Development of New Methods for Sequential Remote Bond Formation Based on the Chain Walking Mechanism

  2018.04

  -

  2022.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 河内　卓彌, Grant-in-Aid for Scientific Research (B), Principal Investigator

• Asymmetric Functionalization of Unreactive C-H Bonds via Chain Walking Using Precisely Designed Catalysts

  2018.04

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  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 河内　卓彌, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

• チェーンウォーキングを活用したプロキラルなメチレンの不斉官能基化

  2016.04

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  2018.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 河内　卓彌, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

• チェーンウォーキングを活用するための遷移状態制御による触媒設計に関する研究

  2015.07

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 河内　卓彌, Grant-in-Aid for Scientific Research (B), Principal Investigator

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Incentive Award in Synthetic Organic Chemistry, Japan

  KOCHI Takuya, 2016.02, The Society of Synthetic Organic Chemistry, Japan, 革新的な物質活性化法を駆使した新しい触媒的分子変換法の開発

  Type of Award： Awards of National Conference, Council and Symposium.  Country： 日本

• Thieme Chemistry Journals Award 2015

  Takuya Kochi, 2015.01, Georg Thieme Verlag

  Type of Award： International Academic Awards.  Country： Germany

• Banyu Chemist Award 2014

  河内　卓彌, 2014.12, 公益財団法人　万有生命科学振興国際交流財団, 新規物質活性化法を駆使した革新的な触媒的官能基変換法の開発

  Type of Award： Awards of Publisher, Newspaper Company and Foundation.  Country： 日本

• 第1回新化学技術研究奨励賞

  河内　卓彌, 2012.05, 公益社団法人　新化学技術推進協会, 元素資源代替としての電気を利用した革新的触媒プロセスの開発

  Type of Award： Awards of National Conference, Council and Symposium.  Country： 日本

• The Young Scientists’ Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

  KOCHI Takuya, 2012.04, 遷移金属触媒を用いた革新的な極性官能基導入法の研究

  Type of Award： Other Awards

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• TOPICS IN ORGANOMETALLIC CHEMISTRY 2

  2021

• SEMINAR IN CHEMISTRY

  2021

• PRACTICAL ORGANIC CHEMISTRY

  2021

• LABORATORIES IN SCIENCE AND TECHNOLOGY

  2021

• LABORATORIES IN CHEMISTRY 2

  2021

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