栄長　泰明 (エイナガ　ヤスアキ)

Einaga, Yasuaki

写真a

所属（所属キャンパス）

理工学部 化学科 （矢上）

職名

教授

HP

外部リンク
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経歴 【 表示 ／ 非表示 】

  • 1997年04月
    -
    1998年03月

    理化学研究所 ,ジュニアリサーチアソシエイト

  • 1998年04月
    -
    1999年11月

    日本学術振興会 ,特別研究員

  • 1999年11月
    -
    2001年03月

    東京大学 ,助手

  • 2001年04月
    -
    2003年03月

    慶應義塾大学理工学部化学科, 専任講師

  • 2003年04月
    -
    2011年03月

    慶應義塾大学理工学部化学科, 助教授/准教授

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学歴 【 表示 ／ 非表示 】

  • 1994年03月

    東京大学, 理学部

    大学, 卒業

  • 1996年03月

    東京大学, 理学系研究科, 化学専攻

    大学院, 修了, 修士

  • 1999年03月

    東京大学, 工学系研究科, 応用化学専攻

    大学院, 修了, 博士

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学位 【 表示 ／ 非表示 】

  • 博士（工学）, 東京大学, 1999年03月

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研究分野 【 表示 ／ 非表示 】

  • ナノテク・材料 / 機能物性化学 (機能物質化学)

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著書 【 表示 ／ 非表示 】

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論文 【 表示 ／ 非表示 】

  • Boron-Doped Diamond Electrode Outperforms the State-of-the-Art Electrochemiluminescence from Microbeads Immunoassay

    Sakanoue K., Fiorani A., Santo C.I., Irkham , Valenti G., Paolucci F., Einaga Y.

    ACS Sensors （ACS Sensors)  7 （ 4 ） 1145 - 1155 2022年04月

    　概要を見る

    Electrochemiluminescence (ECL) is a powerful transduction technique where light emission from a molecular species is triggered by an electrochemical reaction. Application to biosensors has led to a wide range of electroanalytical methods with particular impact on clinical analysis for diagnostic and therapeutic monitoring. Therefore, the quest for increasing the sensitivity while maintaining reproducible and easy procedures has brought investigations and innovations in (i) electrode materials, (ii) luminophores, and (iii) reagents. Particularly, the ECL signal is strongly affected by the electrode material and its surface modification during the ECL experiments. Here, we exploit boron-doped diamond (BDD) as an electrode material in microbead-based ECL immunoassay to be compared with the approach used in commercial instrumentation. We conducted a careful characterization of ECL signals from a tris(2,2′-bipyridine)ruthenium(II) (Ru(bpy)32+)/tri-n-propylamine (TPrA) system, both homogeneous (i.e., free diffusing Ru(bpy)32+) and heterogeneous (i.e., Ru(bpy)32+bound on microbeads). We investigated the methods to promote TPrA oxidation, which led to the enhancement of ECL intensity, and the results revealed that the BDD surface properties greatly affect the ECL emission, so it does the addition of neutral, cationic, or anionic surfactants. Our results from homogeneous and heterogeneous microbead-based ECL show opposite outcomes, which have practical consequences in ECL optimization. In conclusion, by using Ru(bpy)32+-labeled immunoglobulins bound on microbeads, the ECL resulted in an increase of 70% and a double signal-to-noise ratio compared to platinum electrodes, which are actually used in commercial instrumentation for clinical analysis. This research infers that microbead-based ECL immunoassays with a higher sensitivity can be realized by BDD.

  • Electrochemical Oxidation Behavior of Nitrogen Dioxide for Gas Detection Using Boron Doped Diamond Electrodes

    Triana Y., Irkham , Einaga Y.

    Electroanalysis （Electroanalysis)  34 （ 4 ） 752 - 760 2022年04月

    ISSN  10400397

    　概要を見る

    The electrochemical oxidation reaction of nitrogen dioxide (NO2) using boron doped diamond (BDD) electrodes is presented. Cyclic voltammetry of NO2 in a 0.1 M KClO4 solution exhibits oxidation peaks at +1.1 V and +1.5 V (vs. Ag/AgCl) which are attributable to oxidation of HONO and NO2−, respectively. Moreover, the pH and scan rate dependences were investigated to study the oxidation mechanism. A linear calibration curve was observed in the concentration range of ∼1 to 5 mM (R2=0.99) with a detection limit of 11.1 ppb (S/B=3) for HONO and 58.6 ppb (S/B=3) for NO2−. In addition, the analytical performance was compared with those using glassy carbon, platinum and stainless steel as the working electrode.

  • Simultaneous electrochemical detection of ozone and free chlorine with a boron-doped diamond electrode

    Peng Z., Irkham N., Akai K., Murata M., Tomisaki M., Einaga Y.

    Analyst （Analyst)  147 （ 8 ） 1655 - 1662 2022年03月

    ISSN  00032654

    　概要を見る

    O3 and free chlorine play significant roles in disinfection and organic degradation. There are numerous reports about their mixed-use, yet detection of the residual concentrations is not easily accomplished, whilst the interactions between them remain unclear. Herein, we develop a detection method using a boron-doped diamond (BDD) electrode to achieve the simultaneous determination of O3 and free chlorine, which benefits from the unique property of the wide potential window of BDD electrodes. It is indicated that O3 can always be accurately determined at 0.35 V vs. Ag/AgCl in an acidic solution (pH = 4-5), whether or not free chlorine is present in the solution, whereas free chlorine can be precisely monitored at −0.78 V vs. Ag/AgCl only after the O3 is completely depleted. Furthermore, in a basic solution (pH = 9-10), the reduction peak of O3 at 0.57 V vs. Ag/AgCl promptly disappears accompanied by a decrease in the peak current of free chlorine at 1.41 V. All the phenomena observed in the acidic and basic solutions are concurrently confirmed in a quasi-neutral solution. Based on these complementary measurements, a mechanism is proposed, in which the O3 reduction results in partial oxidation of the BDD surface, hindering the reduction of free chlorine in the acidic mixture; whereas O3 reacts quickly with free chlorine in the basic solution, which causes the co-consumption of both of them. It is hoped these results will give us a guide as to how better utilize mixtures and more precisely simultaneously determine O3 and free chlorine in the mixture.

  • Blood Oxygen Sensor Using a Boron-Doped Diamond Electrode

    Triana Y., Ogata G., Tomisaki M., Irkham , Einaga Y.

    Analytical Chemistry （Analytical Chemistry)  94 （ 9 ） 3948 - 3955 2022年03月

    ISSN  00032700

    　概要を見る

    The electrochemical behavior of oxygen (O2) in blood was studied using boron-doped diamond (BDD) electrodes. Cyclic voltammogram of O2 in a 0.1 M phosphate buffer solution solution containing 1 × 10-6 M of bovine hemoglobin exhibits a reduction peak at -1.4 V (vs Ag/AgCl). Moreover, the scan rate dependence was investigated to study the reduction reaction mechanism, which was attributable to the reduction of O2 to H2O2 via two electrons. A linear calibration curve was observed in the concentration range of 86.88-314.63 mg L-1 (R2 = 0.99) with a detection limit of 1.0 mg L-1 (S/B = 3). The analytical performance was better than those with glassy carbon or platinum electrodes as the working electrode. In addition, an application to bovine blood was performed. The O2 concentration in the blood measured on the BDD electrodes was compared to that measured using an OxyLite Pro fiber-optic oxygen sensor device. Both methods gave similar values of the O2 concentration in the range of ∼40 to 150 mmHg. This result confirms that BDD electrodes could potentially be used to detect the O2 concentration in blood.

  • Electrochemical study of CO<inf>2</inf> reduction on Ti<inf>3</inf>C<inf>2</inf>T<inf>x</inf> modified boron-doped diamond electrode

    Jiwanti P.K., Alfaza A.M., Kadja G.T.M., Khalil M., Einaga Y.

    Inorganic Chemistry Communications （Inorganic Chemistry Communications)  137 2022年03月

    ISSN  13877003

    　概要を見る

    The electrochemical reduction of CO2 has been attracted researcher attention around the world. There are many researches on how to improve the value of CO2 gas by converting it to useful chemicals or feedstock. In this report, we studied electrochemical behavior of Ti3C2Tx modified on the surface of boron-doped diamond (BDD) electrode for CO2 reduction. It is shown that the presence of Ti3C2Tx could improve the catalytic effect for CO2 reduction, as the CO2 reduction peak was shifted to positive potentials. This work is expected to provide an information of potential catalyst to be applied for real CO2 reduction application.

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

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総説・解説等 【 表示 ／ 非表示 】

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 革新的sp3機能電極材料の創製

    2019年04月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 栄長　泰明, 基盤研究（Ａ）, 補助金,  研究代表者

  • 光制御可能な超伝導ナノ微粒子の創製

    2016年04月
    -
    2019年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 栄長　泰明, 基盤研究(B), 補助金,  研究代表者

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担当授業科目 【 表示 ／ 非表示 】

  • 化学輪講

    2022年度

  • ナノスケール科学ジョイントセミナー

    2022年度

  • マテリアルデザイン科学ジョイントセミナー

    2022年度

  • 化学実験第１

    2022年度

  • 基礎化学実験

    2022年度

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