Einaga, Yasuaki

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Professor

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Career 【 Display / hide 】

  • 1997.04
    -
    1998.03

    理化学研究所 ,ジュニアリサーチアソシエイト

  • 1998.04
    -
    1999.11

    日本学術振興会 ,特別研究員

  • 1999.11
    -
    2001.03

    東京大学 ,助手

  • 2001.04
    -
    2003.03

    慶應義塾大学理工学部化学科, 専任講師

  • 2003.04
    -
    2011.03

    慶應義塾大学理工学部化学科, 助教授/准教授

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Academic Background 【 Display / hide 】

  • 1994.03

    The University of Tokyo, Faculty of Science

    University, Graduated

  • 1996.03

    The University of Tokyo, Graduate School, Division of Science, 化学専攻

    Graduate School, Completed, Master's course

  • 1999.03

    The University of Tokyo, Graduate School, Division of Science, 応用化学専攻

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（工学）, The University of Tokyo, 1999.03

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Functional solid state chemistry (Functional Material Chemistry)

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Books 【 Display / hide 】

  • Diamond Electrodes: Fundamentals and Applications

    Einaga Y., Diamond Electrodes: Fundamentals and Applications, 2022.01

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    This book introduces the recent development in Japan of diamond electrodes, which has attracted much attention in the world. For example, electrochemical sensors using diamond electrodes are now being utilized commercially. Newly developing applications such as electrochemical organic synthesis including CO2 reduction are also expected to form an important future technology. Those emerging applications to various fields which are receiving increasing attention are described in detail here. This book is useful not only for students who would like to begin their study of diamond electrodes but also for industries that are exploring novel electrochemical applications.

  • Modified Boron-Doped Diamond Electrodes for Sensors and Electroanalysis

    Jiwanti P.K., Atriardi S.R., Putri Y.M.T.A., Ivandini T.A., Einaga Y., Diamond Electrodes: Fundamentals and Applications, 2022.01

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    Boron-doped diamond (BDD) has been established as a superior electrode among other conventional solid electrodes due to its unique properties, such as very low background current, wide potential window, and high physical and chemical stability. However, in compare to metal electrodes, BDD has much lower kinetic activity in some important chemical reactions, which causes limitation for sensor and biosensor applications. Modification of BDD surface with redox-active particles/compounds was reported to facilitate electron transfer between the BDD substrate and analytes with a significant reduction in activation overpotential; therefore, the catalytic activity and sensitivity are improved. In addition, the modification can increase the selectivity in some reactions. On the other hand, to have a stable modified surface of BDD electrode is not easy, since the main composition of BDD is carbon atoms with sp3 configuration, which is very compact and stable, and actually one of the advance characteristics of BDD electrodes. However, the stability of the BDD surface causes the modified surface to be easily detached or dissolved after several usages. In this chapter, preparations and applications of the modified BDD for electrochemical sensors and biosensors are described and compared.

  • Introduction

    Einaga Y., Diamond Electrodes: Fundamentals and Applications, 2022.01

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    A first example of electrochemical measurement using diamond as an electrode is a study by Iwaki et al. (RIKEN) in 1983. This is a preview of subscription content, access via your institution.

  • Industrial Application of Electrochemical Chlorine Sensor

    Einaga Y., Diamond Electrodes: Fundamentals and Applications, 2022.01

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    Monitoring free chlorine concentration is an important issue in various situations. Residual chlorine that does not react with organic compounds, and metals dissolve in water to produce HClO (hypochlorous acid) and ClO- (hypochlorite ion). In 2008, we reported that free chlorine, which has a strong disinfecting effect, can be monitored with high sensitivity using a boron-doped diamond (BDD) electrode. However, the problem of pH fluctuation of the solution and the detailed mechanism of redox have not been completely clarified. Then, in 2016, the electrochemical redox mechanism of this free chlorine was carefully studied. Based on these results, we designed a new system using BDD electrodes that can monitor the free chlorine concentration in real time.

  • In Vivo Real-Time Measurement of Drugs

    Ogata G., Sawamura S., Asai K., Kusuhara H., Einaga Y., Hibino H., Diamond Electrodes: Fundamentals and Applications, 2022.01

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    Drugs play a key role in the treatment of patients with various diseases. A compound, when administered systemically, shows differential spatial and temporal distribution patterns not only in the body but also within each organ. In response to an increase or decrease in local concentrations in the organ, the activity of the cell population expressing the drug’s target protein(s) changes over time. Therefore, real time, simultaneous detection of kinetics of the drug and its pharmacological effects in in vivo microenvironments is essential for evaluating the efficacy of medicines. Although such challenging dual-mode measurement has not yet been addressed by any conventional methods, it has been successfully achieved via a microsensing system that we recently developed. The system consists of two different sensors: A needle-type boron-doped diamond microelectrode for monitoring the drug and a glass microelectrode for tracking electrophysiological activity of the target cells. This state-of-the-art approach is applicable to various drugs in terms of “local” pharmacokinetic and pharmacodynamic assays in vivo and may contribute to the development of next-generation therapeutic interventions.

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Papers 【 Display / hide 】

  • Fabrication of three-dimensional boron-doped diamond electrodes on SiC scaffolds

    Otake A., Diaz-Herrezuelo I., Uchiyama K., Fiorani A., Belmonte M., Einaga Y.

    Diamond and Related Materials (Diamond and Related Materials)  146 2024.06

    ISSN  09259635

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    Three-dimensional (3D) architected electrode materials are expected to exhibit advantageous properties such as enlarged surface area, increased mass transfer, enhanced adsorption and more active sites exposed. In this paper, boron-doped diamond (BDD) electrodes on 3D printed patterned silicon carbide (SiC) scaffolds have been fabricated using chemical vapor deposition (CVD). The stabilization of the plasma sphere by using clamshell type CVD reactor, introducing the outer protecting plate, the optimization of CVD parameters, and the design of 3D-SiC scaffolds improved the sp3/sp2 ratio, uniformity and growth rate of BDD. 3D-BDD electrodes exhibit enough electrical conductivity for electrochemical applications. The preliminary test for electrochemical carbon dioxide reduction (CO2R) has showed the potential advantages of this type of 3D structured BDD electrodes.

  • Fabrication of polycrystalline phosphorus-doped diamond electrodes from red phosphorus

    Moriguchi T., Tomisaki M., Sato S., Nakamura J., Yamada H., Einaga Y.

    Physical Chemistry Chemical Physics (Physical Chemistry Chemical Physics)  26 ( 20 ) 14825 - 14831 2024.05

    ISSN  14639076

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    Polycrystalline phosphorus-doped diamond was fabricated by the quartz-tube-type microwave plasma-assisted chemical vapor deposition method. Significantly, red phosphorus was used as a source of phosphorous, instead of PH3. Phosphorus-doped diamond electrodes with hydrogen-terminated and oxygen-terminated surfaces were investigated for the redox reactions of K3[Fe(CN)6] and [Ru(NH3)6]Cl3. The carrier concentration was estimated as 2.1-5.3 × 1018 cm−3 from electrochemical impedance measurements. Polycrystalline phosphorus-doped diamond shows great promise as chemical electrode materials.

  • Green Synthesis of Ceria Nanoparticles from Cassava Tubers for Electrochemical Aptasensor Detection of SARS-CoV-2 on a Screen-Printed Carbon Electrode

    Zakiyyah S.N., Irkham N., Einaga Y., Gultom N.S., Fauzia R.P., Kadja G.T.M., Gaffar S., Ozsoz M., Hartati Y.W.

    ACS Applied Bio Materials (ACS Applied Bio Materials)  7 ( 4 ) 2488 - 2498 2024.04

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    Green synthesis approaches for making nanosized ceria using starch from cassava as template molecules to control the particle size are reported. The results of the green synthesis of ceria with an optimum calcination temperature of 800 °C shows a size distribution of each particle of less than 30 nm with an average size of 9.68 nm, while the ratio of Ce3+ to Ce4+ was 25.6%. The green-synthesized nanoceria are applied to increase the sensitivity and attach biomolecules to the electrode surface of the electrochemical aptasensor system for coronavirus disease (COVID-19). The response of the aptasensor to the receptor binding domain of the virus was determined with the potassium ferricyanide redox system. The screen-printed carbon electrode that has been modified with green-synthesized nanoceria shows 1.43 times higher conductivity than the bare electrode, while those modified with commercial ceria increase only 1.18 times. Using an optimized parameter for preparing the aptasensors, the detection and quantification limits were 1.94 and 5.87 ng·mL-1, and the accuracy and precision values were 98.5 and 89.1%. These results show that green-synthesized ceria could be a promising approach for fabricating an electrochemical aptasensor.

  • Modification of boron-doped diamond electrode with polyaniline and gold particles to enhance the electrochemiluminescence of luminol for the detection of reactive oxygen species (hydrogen peroxide and hypochlorite)

    Rahmawati I., Fiorani A., Sanjaya A.R., Irkham , Du J., Saepudin E., Einaga Y., Ivandini T.A.

    Diamond and Related Materials (Diamond and Related Materials)  144 2024.04

    ISSN  09259635

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    A luminol electrochemiluminescence (ECL)-based sensor for reactive oxygen species (ROS), including H2O2 and hypochlorite was developed using gold particles-modified on polyaniline‑boron doped diamond electrode (Au-PANI/BDD). The gold particles were incorporated onto the surface of boron-doped diamond (BDD) electrode to enhance the electrochemiluminescence of luminol, while the polyaniline was used to provide better attachment of the gold particles on the surface of BDD electrode. The uniform distribution of gold particles on the PANI/BDD surface was verified through FE-SEM EDX analysis with an approximately weight percentage of 45.6 % (w/w). The modified electrode exhibited a remarkable five-fold increase in ECL intensity compared to the unmodified BDD, resulting in higher sensitivity. Furthermore, the sensor's performance was successfully demonstrated for H2O2 concentrations ranged linearly from 1 to 100 μM (R2 ≥ 0.99) with a low detection limit of 0.81 μM, and for hypochlorite concentrations from 1 to 20 μM (R2 ≥ 0.99) with a detection limit as low as 0.51 μM. Additionally, excellent repeatability and stability of the signals was also observed over 7 days. Furthermore, successful application in detecting H2O2 and hypochlorite in real sample highlights its promising potential as an ROS sensor.

  • Sluggish Electron Transfer of Oxygen-Terminated Moderately Boron-Doped Diamond Electrode Induced by Large Interfacial Capacitance between a Diamond and Silicon Interface

    Otake A., Nishida T., Ohmagari S., Einaga Y.

    JACS Au (JACS Au)  4 ( 3 ) 1184 - 1193 2024.03

    　View Summary

    Boron-doped diamond (BDD) has tremendous potential for use as an electrode material with outstanding characteristics. The substrate material of BDD can affect the electrochemical properties of BDD electrodes due to the different junction structures of BDD and the substrate materials. However, the BDD/substrate interfacial properties have not been clarified. In this study, the electrochemical behavior of BDD electrodes with different boron-doping levels (0.1% and 1.0% B/C ratios) synthesized on Si, W, Nb, and Mo substrates was investigated. Potential band diagrams of the BDD/substrate interface were proposed to explain different junction structures and electrochemical behaviors. Oxygen-terminated BDD with moderate boron-doping levels exhibited sluggish electron transfer induced by the large capacitance generated at the BDD/Si interface. These findings provide a fundamental understanding of diamond electrochemistry and insight into the selection of suitable substrate materials for practical applications of BDD electrodes.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 電解発生活性化学種の利用による新物質変換系の構築

    2023.04
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    2026.03

    基盤研究(A), Principal investigator

  • 革新的sp3機能電極材料の創製

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

  • 光制御可能な超伝導ナノ微粒子の創製

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Courses Taught 【 Display / hide 】

  • INTRODUCTION TO FUNCTIONAL MATERIALS

    2024

  • INDEPENDENT STUDY ON INTEGRATED DESIGN ENGINEERING

    2024

  • GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 2

    2024

  • GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 1

    2024

  • COORDINATION CHEMISTRY (INORGANIC AND ANALYTICAL CHEMISTRY 2)

    2024

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