Hori, Yutaka



Faculty of Science and Technology, Department of Applied Physics and Physico-Informatics (Yagami)


Assistant Professor/Senior Assistant Professor

Related Websites

Career 【 Display / hide

  • 2013.04

    東京大学大学院, 情報理工学系研究科 システム情報学専攻, 特任研究員

  • 2013.09

    California Institute of Technology, Department of Computing and Mathematical Sciences, Postdoctoral Scholar

Academic Background 【 Display / hide

  • 2008.03

    The University of Tokyo, 工学部, 計数工学科

    University, Graduated

  • 2010.03

    The University of Tokyo, 情報理工学系研究科, システム情報学専攻

    Graduate School, Completed, Master's course

  • 2013.03

    The University of Tokyo, 情報理工学系研究科, システム情報学専攻

    Graduate School, Completed

Academic Degrees 【 Display / hide

  • 学士(工学), The University of Tokyo, 2008.03

  • 修士(情報理工学), The University of Tokyo, 2010.03

  • 博士 (情報理工学), The University of Tokyo, 2013.03


Research Areas 【 Display / hide

  • Control engineering/System engineering

Research Keywords 【 Display / hide

  • マイクロ流体デバイス

  • 制御工学

  • 制御理論

  • 合成生物学


Papers 【 Display / hide

  • Finite-Time Stability Analysis for Resource Limited Chemical Reactions

    Matsunaga T., Uemura R., Hori Y.

    IEEE Control Systems Letters (IEEE Control Systems Letters)  5 ( 3 ) 815 - 820 2021.07

     View Summary

    © 2017 IEEE. We consider chemical reaction systems that operate in a resource limited situation such as in a closed test tube. These systems can operate only for a finite interval of time before the system variables deviate from the normal operating region. Thus, in order to characterize the performance of the systems, it is important to analyze the duration of the normal operation, which is closely related to the notion of finite-time stability. In this letter, we propose an algebraic optimization approach to analyze finite-time stability of resource limited chemical reactions. Specifically, we present semidefinite programs that compute guaranteed lower and upper bounds of the duration of the normal operation, which we call survival time, for a given set of uncertain initial concentrations. The proposed semidefinite programs provide progressively tighter bounds of survival time by increasing the variables and constraints, allowing for the tuning of the balance between the computational time and the conservativeness of the bounds. We demonstrate the proposed method using the regenerator circuit of DNA strand displacement reactions.

  • Modeling and Analysis of Stochastic Reaction Kinetics in Biomolecular Systems

    Hori Y.

    New Generation Computing (New Generation Computing)  38 ( 2 ) 367 - 377 2020.05

    ISSN  02883635

     View Summary

    © 2020, Ohmsha, Ltd. and Springer Japan KK, part of Springer Nature. Chemical reactions in small-volume reactors such as biological cells are highly variable due to the stochastic collision events of the small number of molecules. To analyze and design these stochastic biomolecular reactions, computational tools have been developed based on rigorous mathematical foundations. This paper reviews fundamental theory and computational tools for the modeling, analysis, and design of stochastic biomolecular systems. Specifically, we first review the governing equation of the stochastic kinetics using the first principle modeling. Then, three computational approaches are introduced for simulating and/or analyzing the governing equation.

  • Locally Bendable Stimuli-Responsive Hydrogel Actuator with Axially Patterned Functional Materials

    Takeuchi N., Nakajima S., Kawano R., Hori Y., Onoe H.

    Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS))  2020-January   243 - 244 2020.01

    ISSN  9781728135809

     View Summary

    © 2020 IEEE. This paper describes a locally bendable stimuli-responsive hydrogel actuator with axially patterned functional materials fabricated by a valve-controlled microfluidic device. By application of an external stimuli to the complete actuator, it can be locally bended owing to the axial pattern of the responsive and non-responsive material. These materials are axially patterned on a microfiber through the Y-shaped channel coupled with the open/close motion of the valves in the microfluidic device. The microfluidic device can regulate the on/off of the flow by thin membrane pneumatic valves controlled by a computer. The patterning frequency of the two materials in the microfiber could be adjusted by modifying the switching intervals of the solutions. Also, we successfully demonstrated the curvature-change through heating and cooling. We believe that this locally bendable stimuli-responsive hydrogel could contribute to microfiber-shaped soft actuators, biomedical sensors, and self-assembly of complex 3D microstructures.

  • A Quartz Crystal Microbalance Based Portable Gas Sensing Platform for On-Demand Human Breath Monitoring

    Suzuki R., Emura T., Tokura Y., Kawamura N., Hori Y.

    IEEE Access (IEEE Access)  8   146166 - 146171 2020

     View Summary

    © 2013 IEEE. The correlation between gas concentrations in human breath and diseases has been increasingly revealed in recent years, triggering the need for cheap and easy-to-use gas sensors that can detect diseases in their early stages. The gas sensors used in these clinical applications need to be portable and sensitive, and preferably provide on-demand measurements for prompt diagnosis. In this paper, we propose a portable and cost-effective sensor platform that can quickly identify gas concentrations in human breath. Specifically, we combined quartz crystal microbalance (QCM) sensors with a single board computer, Raspberry Pi, to enable real-time data processing and display of the sensor data. A web server was operated on the single board computer, and thus, on-demand visualization of the sensor data was possible using a web browser. A gas quantification protocol was also proposed based on Freundlich's adsorption isotherm. We demonstrated the real-time monitoring of methyl mercaptan (MM) gas over the internet using the developed small sensor device, which can easily be handled in one hand. The limit of detection (LOD) for MM gas was 107 ppb when the sensors were operated for 20 minutes after gas injection. The developed gas sensing platform is unmatched in terms of size and cost compared with analytical devices though less sensitive. These advantages would allow for wide distribution of the developed device to hospitals and individuals in large quantities, leading for behavioral changes for preventive care.

  • Semidefinite programming for Turing instability analysis in molecular communication networks

    Hori Y., Miyazako H.

    Proceedings of the IEEE Conference on Decision and Control (Proceedings of the IEEE Conference on Decision and Control)  2019-December   1874 - 1880 2019.12

    ISSN  9781728113982

     View Summary

    © 2019 IEEE. This paper proposes a computationally tractable algebraic condition for Turing instability, a type of local instability inducing self-organized spatial pattern formation, in molecular communication networks. The molecular communication networks consist of spatially distributed homogeneous compartments, or biological cells, that interact with neighbor compartments using a small number of diffusible chemical species. Thus, the underlying spatio-temporal dynamics of the system can be modeled by reaction-diffusion equations whose diffusion terms are zero for some chemical species. We show that the molecular communication networks are not Turing unstable if and only if certain polynomials are non-negative. This leads to sum-of-squares optimizations for Turing instability analysis. The proposed approach is capable of predicting the formation of spatial patterns in molecular communication networks based on the mathematically rigorous analysis of Turing instability.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Control and Biology: Going Beyond the Boundary, and Fusing

    Yutaka Hori

    計測と制御 58 ( 5 ) 323 - 324 2019.05

    Other article, Single Work

  • Modeling and Analysis of Stochastic Fluctuations in Biomolecular Systems

    Yutaka Hori

    計測と制御 58 ( 4 ) 253 - 257 2019.04

    Introduction and explanation (scientific journal), Single Work

  • Studying at Caltech: How I Enjoyed the Interdisciplinary Culture

    Yutaka Hori

    システム/制御/情報 62 ( 11 ) 443 - 448 2018.11

    Other article

  • 制御工学的アプローチによる遺伝子回路の設計と構築

    Hori Yutaka

    システム/制御/情報 61 ( 5 ) 194 - 199 2017.05

    Introduction and explanation (scientific journal), Single Work

  • Estimation of tibialis anterior muscle stiffness during the swing phase of walking with various footwear

    Takanori Uchiyama, Yutaka Hori, Kenta Suzuki

    Proceedings of the 39th international conference of the IEEE Engineering in Medicine and Biology Society  2017

    Research paper

Presentations 【 Display / hide

  • 微分方程式とガウス過程回帰を用いた微細藻類の細胞増殖予測モデル

    神戸一輝,古志 飛,広川安孝,池田啓二,辻本良真,中村圭祐, 尹熙元

    第63回自動制御連合講演会, 2020.11, Oral Presentation(general)

  • 空間周波数サブシステム分解に基づく細胞間分子通信システムの外乱応答解析


    第63回自動制御連合講演会, 2020.11, Oral Presentation(general)

  • 数理最適化による反応移流拡散システムのパターン形成解析


    第63回自動制御連合講演会, 2020.11, Oral Presentation(general)

  • D/A 変換器のアナロジーを⽤いた動的な溶液 ⼊⼒制御のためのマイクロ流体デバイス

    茶⾕智仁,尾上弘晃,宮廻裕樹, 堀豊

    第4回分子ロボティクス年次大会, 2020.11, Poster (general)

  • DNA 温度計を内包したドロップレットによる DNA 回路の温度特性計測


    第4回分子ロボティクス年次大会, 2020.11, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 第一原理モデルとデータ駆動型モデルの融合による遺伝子回路のロバスト動態予測


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 堀 豊, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • Theory and Experimental Setup for Set based Model Identification of Genetic Circuits using Frequency Response


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 堀 豊, Grant-in-Aid for Research Activity Start-up , Principal Investigator

Intellectual Property Rights, etc. 【 Display / hide

  • 線形予測係数算出装置、線形予測係数算出方法、線形予測係数算出プログラム、および記憶媒体

    Application No.: 2008-051149  2008.02 

    Announcement No.: 2009-210644  2009.09 

    Registration No.: 5057334  2012.08

    Patent, Joint

  • 符号化装置、復号化装置、符号化方法、復号化方法、プログラム、記録媒体

    Application No.: 2008-051150  2008.02 

    Announcement No.: 2009-210645  2009.09 

    Registration No.: 5010293  2012.06

    Patent, Joint


Courses Taught 【 Display / hide











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Memberships in Academic Societies 【 Display / hide

  • 計測自動制御学会

  • システム制御情報学会

  • IEEE


Committee Experiences 【 Display / hide

  • 2020.05

    委員, 計測自動制御学会 ポストコロナ未来社会ワーキンググループ

  • 2020.04

    専門調査員, 文部科学省 科学技術・学術政策研究所

  • 2020.04

    委員, 計測自動制御学会 制御部門 理論部会

  • 2020.04

    主査, 計測自動制御学会 知能分子ロボティクス 調査研究会

  • 2019.09

    Associate Editor, Conference Editorial Board, IEEE Control Systems Society

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