Hori, Yutaka

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Physics and Physico-Informatics (Yagami)

Position

Associate Professor

Related Websites

Career 【 Display / hide

  • 2013.04
    -
    2013.08

    東京大学大学院, 情報理工学系研究科 システム情報学専攻, 特任研究員

  • 2013.09
    -
    2016.03

    California Institute of Technology, Department of Computing and Mathematical Sciences, Postdoctoral Scholar

  • 2017.04
    -
    2019.03

    Institute of Physical and Chemical Research, 統合生命医科学研究センター統合ゲノミクス研究グループ, 客員研究員

Academic Background 【 Display / hide

  • 2008.03

    The University of Tokyo, 工学部, 計数工学科

    University, Graduated

  • 2010.03

    The University of Tokyo, 情報理工学系研究科, システム情報学専攻

    Graduate School, Completed, Master's course

  • 2013.03

    The University of Tokyo, 情報理工学系研究科, システム情報学専攻

    Graduate School, Completed

Academic Degrees 【 Display / hide

  • 学士(工学), The University of Tokyo, 2008.03

  • 修士(情報理工学), The University of Tokyo, 2010.03

  • 博士 (情報理工学), The University of Tokyo, 2013.03

 

Research Areas 【 Display / hide

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Control and system engineering

Research Keywords 【 Display / hide

  • molecular systems

  • molecular robotics

  • 制御工学

  • 制御理論

  • 合成生物学

 

Papers 【 Display / hide

  • Multimolecular Competition Effect as a Modulator of Protein Localization and Biochemical Networks in Cell-Size Space

    Saki Nishikawa, Gaku Sato, Sakura Takada, Shunshi Kohyama, Gen Honda, Miho Yanagisawa, Yutaka Hori, Nobuhide Doi, Natsuhiko Yoshinaga, Kei Fujiwara

    Advanced Science 11 ( 6 ) 2308030 2024.02

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    Cells are small, closed spaces filled with various types of macromolecules. Although it is shown that the characteristics of biochemical reactions in vitro are quite different from those in living cells, the role of the co-existence of various macromolecules in cell-size space remains still elusive. Here, using a constructive approach, it is demonstrated that the co-existence of various macromolecules themselves has the ability to tune protein localization for spatiotemporal regulation and a biochemical reaction system in a cell-size space. Both experimental and theoretical analyses reveal that enhancement of interfacial effects by a large surface-area-to-volume ratio facilitates membrane localization of molecules in the cell-size space, and the interfacial effects are alleviated by competitive binding to lipid membranes among multiple proteins even if their membrane affinities are weak. These results indicate that competition for membrane binding among various macromolecules in the cell-size space plays a role in regulating the spatiotemporal molecular organization and biochemical reaction networks. These findings shed light on the importance of surrounding molecules for biochemical reactions using purified elements in small spaces.

  • Parameter-preserving model order reduction of chemical master equations with a priori error bound

    Masaya Miyazaki, Yutaka Hori

    Proceedings of Asian Control Conference    accepted 2024

    Research paper (international conference proceedings), Joint Work, Accepted

  • Analysis of Signal Distortion in Molecular Communication Channels Using Frequency Response

    Shoichiro Kitada, Taishi Kotsuka, Yutaka Hori

    New Generation Computing    accepted 2024

    Research paper (scientific journal), Joint Work, Accepted

  • Stability analysis for large-scale multi-agent molecular communication systems

    Stability analysis for large-scale multi-agent molecular communication systems

    IEEE Transactions on NanoBioscience  - accepted 2024

    Research paper (scientific journal), Joint Work, Accepted

  • Graphical and Analytical Approaches for Analyzing Collective Behavior of Dynamic Multi-Agent Systems Governed by Generalized Cyclic Pursuit Mechanism

    Taeheon Kwak, Yeongjae Kim, Yutaka Hori, Tae Hyoung Kim

    IEEE Access 11   140481 - 140495 2023.12

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    In this study, we use graphical and analytical methods to study the collective behavior of a swarm of dynamic agents controlled by the generalized cyclic pursuit (GCP) scheme. The proposed graphical approach reveals the occurrence mechanisms of various formation patterns in terms of agents' dynamics and tuning parameters of the GCP scheme, including the rendezvous, diverging spirals, circular pattern, and spirograph-like patterns. Then, we develop an analytical tool to obtain the crucial information needed to formulate expressions of the circular and spirograph-like steady-state trajectories generated by the GCP-controlled dynamic multi-agent system. In addition, the steady-state formation trajectories of a swarm of dynamic agents are formulated by explicitly considering the agents' general continuous-time linear time-invariant model and the scenario in which more than two pairs of closed-loop poles exist on the imaginary axis of the complex plane. Numerical simulation cases of the GCP-controlled dynamic multi-agent system are presented to demonstrate the effectiveness of the proposed analysis methodology.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 生体分子を材料とする人工システムの設計と制御 〜生物と人工物をつなぐためのフレームワーク〜

    堀 豊

    計測と制御 60 ( 7 )  2021.07

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • 確率ゆらぎを利用した生体分子システムの設計

    堀 豊

    計測と制御 60 ( 5 ) 345 - 350 2021.05

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • Modeling and Analysis of Stochastic Reaction Kinetics in Biomolecular Systems

    Yutaka Hori

    New Generation Computing 38 ( 1 )  2020.05

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • Control and Biology: Going Beyond the Boundary, and Fusing

    Yutaka Hori

    計測と制御 58 ( 5 ) 323 - 324 2019.05

    Other, Single Work

  • Modeling and Analysis of Stochastic Fluctuations in Biomolecular Systems

    Yutaka Hori

    計測と制御 58 ( 4 ) 253 - 257 2019.04

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

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Presentations 【 Display / hide

  • 疾病の超早期発見のための分岐現象のモデリング

    井上陽亮, 中島歩, 井上正樹, 堀豊

    第68回システム制御情報学会 研究発表講演会, 

    2024.05

    Oral presentation (general)

  • 安全確率の空間モード分解による大規模自律分散システムの安全性解析

    安永涼真, 仲平依恵, 堀豊

    第68回システム制御情報学会 研究発表講演会, 

    2024.05

    Oral presentation (general)

  • 伝達関数に基づくマルチエージェント分子通信システムの安定性解析

    小塚太資,堀豊

    第7回分子ロボティクス年次大会, 

    2024.03

    Poster presentation

  • 非線形最適レギュレータのモデルフリー設計のための二段階強化学習

    南芽衣, 大川佳寛, 佐々木智丈, 堀豊

    第11回 計測自動制御学会制御部門マルチシンポジウム, 

    2024.03

    Oral presentation (general)

  • プラスミドのコピー数制御を用いた帰還遺伝子回路の外乱抑制

    名村榛乃, 五十嵐 亮人, 堀豊

    第11回 計測自動制御学会制御部門マルチシンポジウム, 

    2024.03

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 反応拡散系として分子的に実装されるニューラルネットワークシステムの開発

    2023.04
    -
    2026.03

    Coinvestigator(s)

  • 再帰性と可塑性を有する分子学習モジュールのシステム設計理論

    2021.09
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 学術変革領域研究(A), Principal investigator

  • Distribution-based design of stochastic response in biomolecular systems

    2021.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 再帰性と可塑性を有する分子学習モジュールのシステム設計理論

    2021
    -
    2022

    文部科学省・日本学術振興会, 科学研究費助成事業, Principal investigator

  • 第一原理モデルとデータ駆動型モデルの融合による遺伝子回路のロバスト動態予測

    2018.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide

  • 線形予測係数算出装置、線形予測係数算出方法、線形予測係数算出プログラム、および記憶媒体

    Date applied: 2008-051149  2008.02 

    Date announced: 2009-210644  2009.09 

    Date issued: 5057334  2012.08

    Patent, Joint

  • 符号化装置、復号化装置、符号化方法、復号化方法、プログラム、記録媒体

    Date applied: 2008-051150  2008.02 

    Date announced: 2009-210645  2009.09 

    Date issued: 5010293  2012.06

    Patent, Joint

 

Courses Taught 【 Display / hide

  • PRESENTATION TECHNIQUE

    2024

  • MODELING AND CONTROL SYSTEM DESIGN

    2024

  • MATHEMATICS FOR APPLIED PHYSICS (B)

    2024

  • MATHEMATICAL THEORY IN BIOMOLECULAR SYSTEMS

    2024

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2024

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Memberships in Academic Societies 【 Display / hide

  • 計測自動制御学会

     
  • システム制御情報学会

     
  • IEEE

     

Committee Experiences 【 Display / hide

  • 2024.04
    -
    2026.03

    Secretary, IEEE Control Systems Society Japan Chapter

  • 2023
    -
    Present

    Associate Editor, IEEE Transactions on Molecular, Biological and Multi-Scale Communications

  • 2022.04
    -
    2024.03

    Treasurer, IEEE Control Systems Society, Japan Chapter

  • 2022.01
    -
    Present

    制御部門・学術委員会委員, 計測自動制御学会

  • 2021

    Guest Editor, Advanced Robotics

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