Papers - Arai, Tsunenori

The NPe6 fluorescence measurements by using a fluorescence sensing system for skin photosensitivity risk assessment after photodynamic therapy

Ohtani K., Usuda J., Ogawa E., Maehara S., Imai K., Inoue T., Hagiwara M., Kakihana M., Kajiwara N., Ohira T., Arai T., Ikeda N.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Progress in Biomedical Optics and Imaging - Proceedings of SPIE)  10476 2018

ISSN  9781510614376

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© 2018 SPIE. Background: Skin photosensitivity is a major side effect of photodynamic therapy (PDT). It is induced by the photosensitizer remaining in the skin. It is usually rapidly metabolized by the liver, but the pharmacokinetic profile varies widely among individuals. This makes it difficult to predict the incidence of skin photosensitivity. Therefore, we conducted a prospective study to investigate whether the NPe6 fluorescence intensity in skin after NPe6-PDT could be measured safely in human patients using a fluorescence sensing system for judging the risk of skin photosensitivity. Methods: The NPe6 fluorescence measurements using a constructed fluorescence sensing system at the inside of the arm were acquired prior to and 5 and 10 minutes after NPe6 administration as well as at the time of PDT (4-5 hours after administration), at discharge (2 or 3 days after PDT), and at 1 or 2 weeks after PDT. Participants were interviewed as to whether they had any complications at 2 weeks after PDT. Results: Nine male patients and one female patient entered this study. All of the measurements of NPe6 fluorescence in the skin could be obtained without any complications. The spectral peak was detected at the time of discharge (2-3 days after administration) in most cases and it decreased at 1 or 2 weeks after PDT. Conclusions: The fluorescence of NPe6 in the skin could be detected feasibly using the fluorescence sensing system in human patients. Measuring fluorescence intensity in the skin might be useful to predict the incidence of skin photosensitivity after PDT.

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Skin fluorescence following photodynamic therapy with NPe6 photosensitizer

K. Ohtani, J. Usuda, E. Ogawa, S. Maehara, K. Imai, Y. Kudo, S. Ono, S.Shigefuku, D. Eriguchi, T. Inoue, J. Maeda, K. Yoshida, M. Hagiwara, M.Kakihana, N. Kajiwara, T. Ohira, T. Arai, N. Ikeda,

Photodiagnosis and Photodynamic Therapy 20   201 - 214 2017.12

Research paper (scientific journal)

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Development of a practical animal model of photodynamic therapy using a high concentration of extracellular talaporfin sodium in interstitial fluid: influence of albumin animal species on myocardial cell photocytotoxicity in vitro

E. Ogawa and T. Arai

Lasers in Medical Science 32 ( 9 ) 2105 - 2109 2017.10

Research paper (scientific journal)

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Temperature influence on myocardial cell cytotoxicity of the extracellular photosensitization reaction with talaporfin sodium and serum proteins at 17–37°C

E. Ogawa, H. Takenoya, T. Arai

Photomedicine and Laser Surgery 35 ( 10 ) 555 - 559 2017.10

Irradiance dependence of the conduction block of an in bitro cardiomyocyte wire

E.Ogawa, M. Kurotsu, T. Arai

Photodiagnosis and Photodynamic Therapy 19   93 - 97 2017.09

Research paper (scientific journal)

Effect of a photosensitization reaction performed during the first 3 minutes after rat myocardial cells exposed to talaporfin sodium in vitro

M. Doi, E. Ogawa, and T. Arai

Lasers in Medical Science 32 ( 8 ) 1873 - 1878 2017.08

Research paper (scientific journal)

Phototoxicity of vascular endothelial cells due to contact with talaporfin sodium for 15–120 min: in vitro and in vivo study

Hamada, Risa; Ogawa, Emiyu; Arai, Tsunenori

Photomedicine and Laser Surgery 35 ( 6 ) 305 - 310 2017.06

レーザによる革新的な非熱的不整脈治療装置：我が国発技術の実用化

ARAI TSUNENORI

月刊オプトロニクス　特集「光・レーザー医学の新潮流」  ( 3 )  2017

Research paper (scientific journal)

3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico

Emiyu Ogawa, Yuko Uno, Keishi Ohtani M.D., Sachio Maehara M.D., Kentaro Imai, Jitsuo Usuda M.D., Shotaro Ono, Tsunenori Arai

Proceedings: Proc. SPIE　Bios 2017 (part of SPIE Photonics WEST)  2017

Research paper (international conference proceedings)

Extracellular talaporfin sodium-induced photosensitization reaction with various albumin animal species on myocardial cells in vitro

Emiyu Ogawa, Tsunenori Arai

Proceedings: Proc. SPIE　Bios 2017 (part of SPIE Photonics WEST)  2017

Research paper (international conference proceedings)

Evaluation of electrical propagation delay with cardiomyocytes by photosensitization reaction in vitro

Marika Doi, Emiyu Ogawa, Tsunenori Arai

Proceedings: Proc. SPIE　Bios 2017 (part of SPIE Photonics WEST)  2017

Research paper (international conference proceedings)

Photosensitization reaction induced hemolysis in a cuvette observed with hemoglobin absorption spectrum of various species

Risa Hamada, Emiyu Ogawa, Tsunenori Arai,

Proceedings: Proc. SPIE　Bios 2017 (part of SPIE Photonics WEST)  2017

Research paper (international conference proceedings)

Laser driven short-term thermal angioplasty: enhancement of drug delivery performance by heating with tension

Kao Suganuma, Rie Homma, Natsumi Shimazaki, Emiyu Ogawa, Tsunenori Arai

Proceedings: Proc. SPIE　Bios 2017 (part of SPIE Photonics WEST)  2017

Research paper (international conference proceedings)

光線力学治療の最先端

ARAI TSUNENORI

医学のあゆみ　　　8.心臓アブレーション治療への応用 258 ( 11 ) 1068 - 1072 2016.09

Research paper (scientific journal)

光増感反応を応用した非熱的不整脈アブレーション治療器の開発

ARAI TSUNENORI

レーザー研究（レーザー学会誌）別紙 44 ( 3 ) 169 - 173 2016.03

実用化まで一息！医工連携で開拓した治療器に世界が注目

ARAI TSUNENORI

東進ハイスクール「2016年版　大学学部研究会号」臨時創刊号  2016

Research paper (bulletin of university, research institution)

Comparison of myocardial cell lethality 2 hours and 24 hours after extracellular talaporfin sodium-induced photosensitization reaction

E. Ogawa, N. Machida, A. Ito, and T. Arai,

Photodiagnosis and Photodynamic Therapy 13   196 - 200 2016

Research paper (scientific journal)

オールジャパンの新規不整脈治療器開発に架ける夢

荒井恒憲、小川恵美悠

応用物理　「応物系　スタートアップ」 85 ( 1 ) 57 - 59 2016

Dependence of damage within 10 min to myocardial cells by a photodynamic reaction with a high concentration of talaporfin sodium outside cells in vitro on parameters of laser irradiation,"

E. Ogawa, A. Ito, and T. Arai

Photodiagnosis Photodyn Ther, 15   1 - 5 2016

Electrical superior vena cava isolation using photodynamic therapy in a canine model

T. Kimura, S. Takatsuki, S. Miyoshi, M. Takahashi, E. Ogawa, K. Nakajima, S. Kashimura, Y. Katsumata, T. Nishiyama, N. Nishiyama, Y. Tanimoto, Y. Aizawa, T. Arai, and K. Fukuda

Europace 18 ( 2 ) 294 - 300 2015.03

Research paper (scientific journal)