Details of a Researcher - Arai, Tsunenori

Arai, Tsunenori

写真a

Affiliation: Faculty of Science and Technology （Mita）

Position: Professor Emeritus

Related Websites

http://www.arai.appi.keio.ac.jp/

External Links

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Career 【 Display / hide 】

1981.04

-

1993.03

防衛医科大学校医用電子工学講座 ,助手
1993.04

-

2001.03

防衛医科大学校医用電子工学講座 ,助教授
1993.04

-

Present

兼慶應義塾大学大学院理工学研究科 ,非常勤講師
1994.04

-

Present

兼防衛医科大学校付属高等看護学院 ,講師

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Academic Background 【 Display / hide 】

1976.03

Keio University, Faculty of Engineering, 電気工学科

University, Graduated
1978.03

Keio University, Graduate School, Division of Engineering, 電気工学専攻

Graduate School, Completed, Master's course
1981.03

Keio University, Graduate School, Division of Engineering, 電気工学専攻

Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

工学　, Keio University, 1981.03

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Books 【 Display / hide 】

Structure and Principle of Angioscope

ARAI TSUNENORI, CORONARY ANGIOSCOPY, 2015

Scope: Springer chapter 1
血管内視鏡最新診療ガイド

ARAI TSUNENORI, 2011.03

Scope: 12-15
MEの基礎知識と安全管理　改訂第4版

ARAI TSUNENORI, ?日本エム・イー学会ME技術教育委員会, 2002.04

Scope: 341-356
皮膚科・形成外科医のためのレーザー治療

ARAI TSUNENORI, メディカルビュー社, 2000.08
消化器研究の新たな進歩Vol.4

中村直子、林　琢也、伊藤和郎、三浦総一郎、荒井恒憲、菊地眞, ヴァン・メディカル, 1999.12

Scope: 83-87

　View Summary

上部消化管内視鏡下でのウォータージェットの応用に関して記述した。

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Papers 【 Display / hide 】

Modified optical coefficient measurement system for bulk tissue using an optical fiber insertion with varying field of view and depth at the fiber tip

Nakazawa H., Doi M., Ogawa E., Arai T.

Lasers in Medical Science （Lasers in Medical Science) 34 （ 8 ） 1613 - 1618 2019.10

ISSN 02688921

　View Summary

© 2019, Springer-Verlag London Ltd., part of Springer Nature. To measure the few millimeter–scale macroscopic optical properties of biological tissue, including the scattering coefficient, while avoiding the instability that originates from sample slicing preparation processes, we performed propagated light intensity measurements through an optical fiber that punctures the bulk tissue while varying the fiber tip depth and the field of view (FOV) at the tip; the results were analyzed using the inverse Monte Carlo method. We realized FOV changes at the fiber tip in the bulk tissue using a variable aperture that was located outside the bulk tissue through a short high-numerical aperture (high-NA) multi-mode fiber with a quasi-straight shape. Using a homogeneous optical model solution, we verified the principle and operation of the constructed experimental system. A 200-μm-core-diameter silica fiber with NA of 0.5 and length of 1 m installed in a 21G needle was used. The detection fiber’s shape was maintained over a radius of curvature of 30 cm. The dependences of the detected light intensity on the FOV and the depth showed better than 1.4% accuracy versus calculated dependences based on the measured optical properties of the solution. Adaptation of the method for use with complex structured biological tissue, particularly in the presence of a thick fascia, was not completely resolved. However, we believe that our specific fiber puncture–based measurement method for use in bulk tissue based on variation of the FOV with inverse Monte Carlo method-based analysis will be useful in obtaining optical coefficients while avoiding sample preparation–related instabilities.
- Access to Document (DOI)
A three-compartment pharmacokinetic model to predict the interstitial concentration of talaporfin sodium in the myocardium for photodynamic therapy: a method combining measured fluorescence and analysis of the compartmental origin of the fluorescence

Yuko Uno, Emiyu Ogawa, Eitaro Aiyoshi, Tsunenori Arai

Bioengneering （Bioengineering) 6 （ 1 ） 1 - 11 2019.03

Research paper (scientific journal), Joint Work

　View Summary

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. To evaluate the effectiveness of photodynamic therapy occurring in the interstitial space of the myocardium, we estimated the interstitial concentration of talaporfin sodium in the canine myocardium by constructing a three-compartment pharmacokinetic model based on measured changes in talaporfin sodium plasma concentration and myocardial fluorescence. Differential rate equations of talaporfin sodium concentration in the plasma, interstitial space, and cell compartment were developed with individual compartment volume, concentration, and rate constants. Using measured volume ratios based on histological examinations, we defined that the myocardial fluorescence consisted of the linear addition of fluorescence generated from these three compartments. The rate constants were obtained by fitting to minimize the sum of the squared errors between the measured talaporfin sodium concentrations and the calculated concentrations divided by the number of data points using the conjugate gradient method in MATLAB. We confirmed that this fitting operation may be appropriate, because a coefficient of determination between the measured talaporfin sodium changes and the calculated concentrations using our equations was 0.99. Consequently, to estimate the interstitial concentration in the canine myocardium, we propose a three-compartment pharmacokinetic model construction methodology using measured changes in talaporfin sodium plasma concentration and changes in myocardial fluorescence.
- Access to Document (DOI)
Heat enhances ex vivo paclitaxel delivery to porcine carotid artery walls

Rie Homma, Machiko Shinozuka, Natsumi Shimazaki, Emiyu Ogawa, Tsunenori Arai

Advanced Biomedical Engineering 8 （ 1 ） 30 - 37 2019.01

Research paper (scientific journal), Joint Work, Accepted
Effect of interactive pressure on drug delivery to ex vivo heated porcine carotid artery walls

Misaki Kobayashi, Kao Suganuma, Natsumi Shimazaki, Emiyu Ogawa, Tsunenori Arai

Advanced Biomedical Engineering 8 （ 1 ） 38 - 44 2019

Research paper (scientific journal), Joint Work
Continuous optical monitoring of red blood cells during a photosensitization reaction

Hamada, Risa; Ogawa, Emiyu; Arai, Tsunenori

Photomedicine and Laser Surgery 36 2019

Research paper (scientific journal), Joint Work, Accepted

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Reviews, Commentaries, etc. 【 Display / hide 】

「心筋内レーザ励起光増感反応による非熱的不整脈治療装置の開発」

ARAI TSUNENORI

レーザー協会誌　特集「医工連携におけるレーザの活用技術」 38 ( 3 ) 2013.12

Article, review, commentary, editorial, etc. (scientific journal)
pdtの不整脈治療への応用：PDTアブレーション装置の開発

ARAI TSUNENORI

O plus E　特集「広がるレーザー応用」 35 ( 5 ) 2013.05

Article, review, commentary, editorial, etc. (scientific journal)

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Presentations 【 Display / hide 】

光増感反応を用いた非熱的不整脈アブレーションの開発

ARAI TSUNENORI

レーザー学会学術講演会第39回年次大会 (東京：東海大学高輪キャンパス) ,

2019.01
,
Symposium, workshop panel (nominated)
光線力学的治療と、大学からの治療器実用化の挑戦

荒井恒憲

第136回関東連合産婦人科学会総会・学術集会 (東京：一橋大学一橋講堂) ,

2018.11
,
Public lecture, seminar, tutorial, course, or other speech
大学発治療器技術の実用化：新規不整脈治療器を目指したチャレンジの総括

荒井恒憲，小川恵美悠，高月誠司

LASER WEEK in Tokyo（第39回日本レーザー医学会総会, 第28回日本光線力学学会，第１4回日本脳神経外科光線力学学会（同時開催）） (東京：京王プラザホテル) ,

2018.11
,
Symposium, workshop panel (nominated)
光ファイバー穿刺によるバルク組織の光学定数計測法

中澤春奈，土井万理香，小川恵美悠，荒井恒憲

LASER WEEK in Tokyo（第39回日本レーザー医学会総会, 第28回日本光線力学学会，第１4回日本脳神経外科光線力学学会（同時開催）） (東京：京王プラザホテル) ,

2018.11
,
Oral presentation (general)
PDT の犬と猫の臨床応用～現状での問題点について～

入江充洋，秋元治朗，荒井恒憲

LASER WEEK in Tokyo（第39回日本レーザー医学会総会, 第28回日本光線力学学会，第１4回日本脳神経外科光線力学学会（同時開催）） (東京：京王プラザホテル) ,

2018.11
,
Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

早期Photodynamic Therapyによる経カテーテル的心房細動治療器

2007.07

-

2010.03

-, Research grant, No Setting

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Works 【 Display / hide 】

第16回日本心臓内視鏡講習会「血管内視鏡の原理」

荒井恒憲

東京：砂防会館,

2018.09
,
Other
『大学学部研究会』株式会ナガセ（東進ハイスクール）理工学部で最新レーザ治療器を開発する！

荒井恒憲

2018.08
,
Other
東京女子医科大学・先端生命医科学研究所バイオメディカル・カリキュラム(BMC)「レーザー医学」

ARAI TSUNENORI

2018.05
,
Other
Friends Live 2018 共済セミナー4　テーマ　Multiplication　～ Opening of IVUS x NIRS ～

荒井恒憲

東京都品川区,

2018.03
,
Other
第38回　日本レーザー医学会総会　大会長

横浜市港北区　,

2017.11
,
Other

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Intellectual Property Rights, etc. 【 Display / hide 】

評価装置

Date applied： 2012066239 2011.03

Date issued： 183946 2014.05

Patent, Joint
光化学反応により心筋組織の光線力学的アブレーションを行うカテーテル

Date applied： 2012-501915 2011.02

Date issued： 5598935 2014.08

Patent, Joint
評価装置

Date applied：特願2010-275511 2010.12

Date issued： 5719159 2015.03

Patent, Joint
爪真菌症治療システム

Date applied：特願2011-545255 2010.12

Date issued： 5699091 2015.02

Patent, Joint
判別装置

Date applied：特願2010-058384 2010.03

Date issued： 5635282 2014.10

Patent, Joint