三浦 洋平 (ミウラ ヨウヘイ)

Miura Youhei

写真a

所属(所属キャンパス)

理工学部 応用化学科 (矢上)

職名

専任講師

学歴 【 表示 / 非表示

  • 2004年04月
    -
    2008年03月

    茨城大学, 理学部, 自然機能科学科

    大学, 卒業

  • 2008年04月
    -
    2009年09月

    北海道大学, 理学院, 化学専攻

    大学院, 修了, 博士前期

  • 2009年10月
    -
    2012年09月

    北海道大学, 理学院, 化学専攻

    大学院, 修了, 博士後期

学位 【 表示 / 非表示

  • 博士(理学), 北海道大学

 

研究分野 【 表示 / 非表示

  • ナノテク・材料 / 基礎物理化学

  • ナノテク・材料 / 機能物性化学

  • ナノテク・材料 / 構造有機化学、物理有機化学

研究キーワード 【 表示 / 非表示

  • 含窒素芳香族化合物

  • 有機合成

  • 有機結晶

  • 有機蛍光分子

  • 機能性化合物

 

論文 【 表示 / 非表示

  • 4-Arylethynyl-5-fluorobenzoyl-1-methylimidazole Exhibiting Self-Recovering Mechanofluorochromism and Forming Fluorescence Molecular Glass

    Miura Youhei, Murai Kazuki, Yamada Kazufumi, Yoshioka Naoki

    Bulletin of the Chemical Society of Japan (公益社団法人 日本化学会)  94 ( 10 ) 2444 - 2450 2021年10月

    ISSN  0009-2673

     概要を見る

    <p>4-Arylethynyl-5-fluorobenzoyl-1-methyl-1<i>H</i>-imidazoles exhibited self-recovering mechanofluorochromism and formed a glass state. Although the solid sample of the anisyl-substituted <b>1a</b> and dimethoxyphenyl-substituted <b>1b</b> exhibited no and blue fluorescence, respectively, they exhibited bluish-green fluorescence after grinding. These compounds recovered the color of their fluorescence after approximately 20 s and after 20 h, respectively. Both compounds exhibited non-crystalline samples after melting and rapid cooling to room temperature. Based on thermal analysis, it was found <b>1a</b> and <b>1b</b> were supercooling liquid and glass, respectively, at room temperature. Both non-crystalline samples exhibited fluorescence at a wavelength longer than that of the solid state. DFT calculations indicated that the bluish-green fluorescence of the ground and non-crystalline samples was derived from the twisted intramolecular charge transfer excitation state.</p>

  • Isolation and Total Synthesis of Bromoiesol sulfates, Antitrypanosomal arylethers from a Salileptolyngbya sp. Marine Cyanobacterium

    Ebihara A., Iwasaki A., Miura Y., Jeelani G., Nozaki T., Suenaga K.

    Journal of Organic Chemistry (Journal of Organic Chemistry)  86 ( 17 ) 11763 - 11770 2021年09月

    ISSN  00223263

     概要を見る

    Bromoiesol sulfates A (1) and B (2), new polyhalogenated aryl sulfates, were isolated from a Salileptolyngbya sp. marine cyanobacterium along with their hydrolyzed compounds, bromoiesols A (3) and B (4). To pick up the candidates of their structures, we used Small Molecule Accurate Recognition Technology (SMART), an artificial intelligence-based structure-prediction tool, and their structures were elucidated on the basis of single-crystal X-ray diffraction analysis of bromoiesols (3 and 4). In addition, to verify the structures, the total synthesis of bromoiesol A sulfate (1) and bromoiesol A (3) was achieved. The bromoiesol family, especially bromoiesols (3 and 4), selectively inhibited the growth of the bloodstream form of Trypanosoma brucei rhodesiense, the causative agent of human African sleeping sickness.

  • V-shaped fluorophores with a 1-methyl-4,5-bis(arylethynyl)imidazole skeleton displaying solid-state fluorescence, acid responsiveness, and remarkable fluorescence solvatochromism

    Miura Y., Kobayashi K., Yoshioka N.

    New Journal of Chemistry (New Journal of Chemistry)  45 ( 2 ) 898 - 905 2021年01月

    ISSN  11440546

     概要を見る

    Novel V-shaped fluorophores with an imidazole skeleton composed of arylethynyl moieties were developed. Their HOMO-LUMO energy gaps were well controlled by the introduction of electron-withdrawing or -donating groups in the aryl moiety. Compounds with different substituents at the 4- and 5-positions were selectively synthesized exploiting the difference in reactivity between the iodo and bromo groups. All compounds synthesized displayed fluorescence not only in solution but also in the solid state. The compound with a donor-acceptor structure displayed a fluorescence maximum with a wavelength over 500 nm and a large Stokes shift of about 150 nm, due to its intramolecular charge transfer character. In the solid state, the synthesized compounds have planar structures, indicating an expansion of π-conjugation. Upon exposure of the compounds in the solid state to acid vapor, the fluorescence of the compounds with acceptor groups was quenched, and that of the others shifted to longer wavelengths.

  • 5,12-Diacetyl-5,12-dihydroquinoxalino[2,3-b]quinoxalines: Solid-State Fluorescence, AIE Properties, and Orbital Switching by Substituent Effect

    Miura Y., Yoshioka N.

    Chemistry - An Asian Journal (Chemistry - An Asian Journal)  13 ( 13 ) 1683 - 1687 2018年07月

    研究論文(学術雑誌),  ISSN  1861-4728

     概要を見る

    © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The compound 5,12-diacetyl-5,12-dihydroquinoxalino[2,3-b]quinoxaline 1 a and its derivatives were prepared, and their solid- and solution-state spectroscopic properties were studied; 1 a shows stronger fluorescence in solution than in the solid state due to aggregation caused by self-quenching. Phenyl- or alkoxy-substituted derivatives 1 b–d show solid-state fluorescence with moderate quantum yields of about Φ=0.12–0.15, although the corresponding values are 0.01–0.07 in solution. The spectroscopic properties of alkoxy-substituted derivatives were hardly changed compared to 1 a and 1 b, although 1 a and 1 b have similar absorption and fluorescence maxima in solution and in the solid state. DFT calculations indicate that orbital switching occurs between HOMO and HOMO-1 and HOMO-2 due to orbital interactions with introduced substituents. Crystal structure analysis revealed that the molecules have bent structures around tertiary nitrogen atoms and form a characteristic dimeric structure.

  • Magnetic Interactions through a Nonconjugated Framework Observed in Back-to-Back Connected Triazinyl–Nitroxyl Biradical Derivatives

    Takahashi Y., Matsuhashi R., Miura Y., Yoshioka N.

    Chemistry - A European Journal (Chemistry - A European Journal)  24 ( 31 ) 7939 - 7948 2018年06月

    研究論文(学術雑誌),  ISSN  0947-6539

     概要を見る

    © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Three hetero-biradical derivatives, with the structure of a back-to-back connected benzotriazinyl and tetramethyl or tetraethylisoindoline N-oxyl sharing a common benzo ring, 3-tert-butyl-1-phenyl-1,4,6,8-tetrahydro-6,6,8,8-tetramethyl-pyrrolo[4,5-g]-1,2,4-benzotriazin-4-yl-7-oxyl (1-tBu), 1,3-diphenyl-1,4,6,8-tetrahydro-6,6,8,8-tetramethyl-pyrrolo[4,5-g]-1,2,4-benzotriazin-4-yl-7-oxyl (1-Ph), and 3-tert-butyl-1-phenyl-1,4,6,8-tetrahydro-6,6,8,8-tetraethyl-pyrrolo[4,5-g]-1,2,4-benzotriazin-4-yl-7-oxyl (2-tBu), were synthesized and characterized by single-crystal X-ray analyses, variable-temperature magnetic susceptibility studies, and DFT calculations. Temperature dependences of the magnetic susceptibilities of 1-tBu, 1-Ph, and 2-tBu exhibit broad maxima at 70, 71, and 43 K, respectively. Although these radical derivatives form a columnar or chained assembly in the solid state, magnetic measurements of diluted samples in the polymer matrices and computational results imply that the magnetic properties of the polycrystalline sample can be explained by a two-spin system with an intramolecular antiferromagnetic interaction. The magnetic behavior can be reproduced by using the Bleaney–Bowers model, with 2J=−80.0 cm−1 for 1-tBu, 2J=−77.1 cm−1 for 1-Ph, and 2J=−48.9 cm−1 for 2-tBu. The moderately strong intramolecular antiferromagnetic interactions can be interpreted by a through-bond interaction through the nonconjugated framework and/or through-space interactions based on molecular orbital theory. The strong distance dependency between the N−O spin site and vinylic carbon atoms indicates that the orbital interaction plays an important role in the intramolecular magnetic interaction. The reduced magnetic interaction in 2-tBu relative to those of 1-tBu and 1-Ph can be attributed to restricted rotation of the tetraethyl group.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

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競争的研究費の研究課題 【 表示 / 非表示

  • 小分子を利用した非π縮環型新奇機能性有機蛍光材料の開発

    2021年04月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 三浦 洋平, 基盤研究(C), 補助金,  研究代表者

 

担当授業科目 【 表示 / 非表示

  • 応用化学輪講

    2022年度

  • マテリアル科学3

    2022年度

  • 理工学基礎実験

    2022年度

  • 応用化学実験C

    2022年度

  • 化学B

    2022年度

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所属学協会 【 表示 / 非表示

  • 日本化学会, 

    2008年
    -
    継続中
  • 基礎有機化学会

     

委員歴 【 表示 / 非表示

  • 2022年04月
    -
    2022年09月

    第16回分子科学討論会2022実行委員

  • 2021年08月
    -
    2021年09月

    第29回有機結晶シンポジウム実行委員

  • 2016年05月
    -
    2017年03月

    会場・総務小委員会 委員, 日本化学会

  • 2015年
    -
    継続中

    慶應有機化学若手シンポジウム実行委員, 慶應有機化学若手シンポジウム実行委員会