Miura Youhei

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry (Yagami)

Position

Assistant Professor/Senior Assistant Professor

Academic Background 【 Display / hide

  • 2004.04
    -
    2008.03

    Ibaraki University, 理学部, 自然機能科学科

    University, Graduated

  • 2008.04
    -
    2009.09

    Hokkaido University, 理学院, 化学専攻

    Graduate School, Completed, Master's course

  • 2009.10
    -
    2012.09

    Hokkaido University, 理学院, 化学専攻

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(理学), Hokkaido University

 

Research Areas 【 Display / hide

  • Nanotechnology/Materials / Fundamental physical chemistry

  • Nanotechnology/Materials / Functional solid state chemistry

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

Research Keywords 【 Display / hide

  • Nitrogen containing aromatic compounds

  • 有機合成

  • 有機結晶

  • 有機蛍光分子

  • 機能性化合物

 

Papers 【 Display / hide

  • Thermosalient Effect of 5-Fluorobenzoyl-4-(4-methoxyphenyl)ethynyl-1-methylimidazole without Phase Transition

    Miura Y., Takeda T., Yoshioka N., Akutagawa T.

    Crystal Growth and Design (Crystal Growth and Design)  22 ( 10 ) 5904 - 5911 2022.10

    Lead author,  ISSN  15287483

     View Summary

    5-Fluorobenzoyl-4-(4-methoxyphenyl)ethynyl-1-methylimidazole 1 exhibited a thermosalient effect without phase transition. The crystal of 1 was jumped by heating to about 80 °C using a hot plate. No phase transition peak was observed at this temperature range according to DSC measurement, unlike renowned thermosalient crystals. Variable-temperature X-ray crystal structure analyses revealed that anisotropical cell constant expansion resulting from the torsion angle change between the imidazole group and carbonyl moiety induced unit cell constant expansion and the thermosalient effect.

  • 4-Arylethynyl-5-fluorobenzoyl-1-methylimidazole Exhibiting Self-Recovering Mechanofluorochromism and Forming Fluorescence Molecular Glass

    Miura Youhei, Murai Kazuki, Yamada Kazufumi, Yoshioka Naoki

    Bulletin of the Chemical Society of Japan (The Chemical Society of Japan)  94 ( 10 ) 2444 - 2450 2021.10

    ISSN  0009-2673

     View Summary

    <p>4-Arylethynyl-5-fluorobenzoyl-1-methyl-1<i>H</i>-imidazoles exhibited self-recovering mechanofluorochromism and formed a glass state. Although the solid sample of the anisyl-substituted <b>1a</b> and dimethoxyphenyl-substituted <b>1b</b> exhibited no and blue fluorescence, respectively, they exhibited bluish-green fluorescence after grinding. These compounds recovered the color of their fluorescence after approximately 20 s and after 20 h, respectively. Both compounds exhibited non-crystalline samples after melting and rapid cooling to room temperature. Based on thermal analysis, it was found <b>1a</b> and <b>1b</b> were supercooling liquid and glass, respectively, at room temperature. Both non-crystalline samples exhibited fluorescence at a wavelength longer than that of the solid state. DFT calculations indicated that the bluish-green fluorescence of the ground and non-crystalline samples was derived from the twisted intramolecular charge transfer excitation state.</p>

  • Isolation and Total Synthesis of Bromoiesol sulfates, Antitrypanosomal arylethers from a Salileptolyngbya sp. Marine Cyanobacterium

    Ebihara A, Iwasaki A, Miura Y, Jeelani G, Nozaki T, Suenaga K

    Journal of Organic Chemistry (Journal of Organic Chemistry)  86 ( 17 ) 11763 - 11770 2021.09

    ISSN  00223263

     View Summary

    Bromoiesol sulfates A (1) and B (2), new polyhalogenated aryl sulfates, were isolated from a Salileptolyngbya sp. marine cyanobacterium along with their hydrolyzed compounds, bromoiesols A (3) and B (4). To pick up the candidates of their structures, we used Small Molecule Accurate Recognition Technology (SMART), an artificial intelligence-based structure-prediction tool, and their structures were elucidated on the basis of single-crystal X-ray diffraction analysis of bromoiesols (3 and 4). In addition, to verify the structures, the total synthesis of bromoiesol A sulfate (1) and bromoiesol A (3) was achieved. The bromoiesol family, especially bromoiesols (3 and 4), selectively inhibited the growth of the bloodstream form of Trypanosoma brucei rhodesiense, the causative agent of human African sleeping sickness.

  • V-shaped fluorophores with a 1-methyl-4,5-bis(arylethynyl)imidazole skeleton displaying solid-state fluorescence, acid responsiveness, and remarkable fluorescence solvatochromism

    Youhei Miura, Kotaro Kobayashi, Naoki Yoshioka

    New Journal of Chemistry (Royal Society of Chemistry (RSC))  45 ( 2 ) 898 - 905 2021.01

    Accepted,  ISSN  11440546

     View Summary

    <p>V-Shaped fluorophores with a 1-methyl-4,5-bis(arylethynyl)imidazole skeleton displayed both solid-state and solution fluorescence, which remarkably changed on exposure to acid vapor.</p>

  • 5,12-Diacetyl-5,12-dihydroquinoxalino[2,3-b]quinoxalines: Solid-State Fluorescence, AIE Properties, and Orbital Switching by Substituent Effect

    Miura, Youhei, Yoshioka, Naoki

    CHEMISTRY-AN ASIAN JOURNAL (Chemistry - An Asian Journal)  13 ( 13 ) 1683 - 1687 2018.07

    Research paper (scientific journal),  ISSN  1861-4728

     View Summary

    © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The compound 5,12-diacetyl-5,12-dihydroquinoxalino[2,3-b]quinoxaline 1 a and its derivatives were prepared, and their solid- and solution-state spectroscopic properties were studied; 1 a shows stronger fluorescence in solution than in the solid state due to aggregation caused by self-quenching. Phenyl- or alkoxy-substituted derivatives 1 b–d show solid-state fluorescence with moderate quantum yields of about Φ=0.12–0.15, although the corresponding values are 0.01–0.07 in solution. The spectroscopic properties of alkoxy-substituted derivatives were hardly changed compared to 1 a and 1 b, although 1 a and 1 b have similar absorption and fluorescence maxima in solution and in the solid state. DFT calculations indicate that orbital switching occurs between HOMO and HOMO-1 and HOMO-2 due to orbital interactions with introduced substituents. Crystal structure analysis revealed that the molecules have bent structures around tertiary nitrogen atoms and form a characteristic dimeric structure.

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 小分子を利用した非π縮環型新奇機能性有機蛍光材料の開発

    2021.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 三浦 洋平, Grant-in-Aid for Scientific Research (C), Principal investigator

 

Courses Taught 【 Display / hide

  • SEMINAR IN APPLIED CHEMISTRY

    2022

  • MATERIAL SCIENCE 3

    2022

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2022

  • LABORATORIES IN APPLIED CHEMISTRY C

    2022

  • CHEMISTRY B

    2022

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Courses Previously Taught 【 Display / hide

  • CHEMISTRY B

    Keio University

    2022.04
    -
    2023.03

  • MATERIAL SCIENCE 3

    Keio University

    2022.04
    -
    2023.03

  • CHEMISTRY B

    Keio University

    2021.04
    -
    2022.03

 

Memberships in Academic Societies 【 Display / hide

  • 日本化学会, 

    2008
    -
    Present
  • The Society of Physical Organic Chemistry, Japan

     

Committee Experiences 【 Display / hide

  • 2022.04
    -
    2022.09

    第16回分子科学討論会2022実行委員

  • 2021.08
    -
    2021.09

    第29回有機結晶シンポジウム実行委員

  • 2016.05
    -
    2017.03

    会場・総務小委員会 委員, 日本化学会

  • 2016.05
    -
    2017.03

    会場・総務小委員会 委員, 日本化学会

  • 2015
    -
    Present

    慶應有機化学若手シンポジウム実行委員, 慶應有機化学若手シンポジウム実行委員会