KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2011.04

  -

  2012.09

  日本学術振興会, 特別研究員(DC2)

• 2012.10

  -

  2013.03

  日本学術振興会, 特別研究員(PD)

• 2013.04

  -

  2016.03

  慶應義塾大学理工学部応用化学科, 助教(有期)

• 2016.04

  -

  2019.03

  慶應義塾大学理工学部応用化学科, 助教

• 2017.04

  -

  2019.03

  慶應義塾大学理工学部応用化学科, クラス担任

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2004.04

  -

  2008.03

  Ibaraki University, 理学部, 自然機能科学科

  University, Graduated

• 2008.04

  -

  2009.09

  Hokkaido University, 理学院, 化学専攻

  Graduate School, Completed, Master's course

• 2009.10

  -

  2012.09

  Hokkaido University, 理学院, 化学専攻

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士(理学), Hokkaido University

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Nanotechnology/Materials / Fundamental physical chemistry

• Nanotechnology/Materials / Functional solid state chemistry

• Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Nitrogen containing aromatic compounds

• 有機合成

• 有機結晶

• 有機蛍光分子

• 機能性化合物

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Thermosalient Effect of 5-Fluorobenzoyl-4-(4-methoxyphenyl)ethynyl-1-methylimidazole without Phase Transition

  Miura Y, Takeda T, Yoshioka N, Akutagawa T

  Crystal Growth and Design (Crystal Growth and Design)  22 ( 10 ) 5904 - 5911 2022.10

  Lead author,  ISSN  15287483

  　View Summary

  5-Fluorobenzoyl-4-(4-methoxyphenyl)ethynyl-1-methylimidazole 1 exhibited a thermosalient effect without phase transition. The crystal of 1 was jumped by heating to about 80 °C using a hot plate. No phase transition peak was observed at this temperature range according to DSC measurement, unlike renowned thermosalient crystals. Variable-temperature X-ray crystal structure analyses revealed that anisotropical cell constant expansion resulting from the torsion angle change between the imidazole group and carbonyl moiety induced unit cell constant expansion and the thermosalient effect.

  • Access to Document (DOI)

• 4-Arylethynyl-5-fluorobenzoyl-1-methylimidazole Exhibiting Self-Recovering Mechanofluorochromism and Forming Fluorescence Molecular Glass

  Miura Youhei, Murai Kazuki, Yamada Kazufumi, Yoshioka Naoki

  Bulletin of the Chemical Society of Japan (The Chemical Society of Japan)  94 ( 10 ) 2444 - 2450 2021.10

  ISSN  0009-2673

  　View Summary

  <p>4-Arylethynyl-5-fluorobenzoyl-1-methyl-1<i>H</i>-imidazoles exhibited self-recovering mechanofluorochromism and formed a glass state. Although the solid sample of the anisyl-substituted <b>1a</b> and dimethoxyphenyl-substituted <b>1b</b> exhibited no and blue fluorescence, respectively, they exhibited bluish-green fluorescence after grinding. These compounds recovered the color of their fluorescence after approximately 20 s and after 20 h, respectively. Both compounds exhibited non-crystalline samples after melting and rapid cooling to room temperature. Based on thermal analysis, it was found <b>1a</b> and <b>1b</b> were supercooling liquid and glass, respectively, at room temperature. Both non-crystalline samples exhibited fluorescence at a wavelength longer than that of the solid state. DFT calculations indicated that the bluish-green fluorescence of the ground and non-crystalline samples was derived from the twisted intramolecular charge transfer excitation state.</p>

  • Access to Document (DOI)
  • CiNii Research

• Isolation and Total Synthesis of Bromoiesol sulfates, Antitrypanosomal arylethers from a Salileptolyngbya sp. Marine Cyanobacterium

  Ebihara A, Iwasaki A, Miura Y, Jeelani G, Nozaki T, Suenaga K

  Journal of Organic Chemistry (Journal of Organic Chemistry)  86 ( 17 ) 11763 - 11770 2021.09

  ISSN  00223263

  　View Summary

  Bromoiesol sulfates A (1) and B (2), new polyhalogenated aryl sulfates, were isolated from a Salileptolyngbya sp. marine cyanobacterium along with their hydrolyzed compounds, bromoiesols A (3) and B (4). To pick up the candidates of their structures, we used Small Molecule Accurate Recognition Technology (SMART), an artificial intelligence-based structure-prediction tool, and their structures were elucidated on the basis of single-crystal X-ray diffraction analysis of bromoiesols (3 and 4). In addition, to verify the structures, the total synthesis of bromoiesol A sulfate (1) and bromoiesol A (3) was achieved. The bromoiesol family, especially bromoiesols (3 and 4), selectively inhibited the growth of the bloodstream form of Trypanosoma brucei rhodesiense, the causative agent of human African sleeping sickness.

  • Access to Document (DOI)

• V-shaped fluorophores with a 1-methyl-4,5-bis(arylethynyl)imidazole skeleton displaying solid-state fluorescence, acid responsiveness, and remarkable fluorescence solvatochromism

  Youhei Miura, Kotaro Kobayashi, Naoki Yoshioka

  New Journal of Chemistry (Royal Society of Chemistry (RSC))  45 ( 2 ) 898 - 905 2021.01

  Accepted,  ISSN  11440546

  　View Summary

  <p>V-Shaped fluorophores with a 1-methyl-4,5-bis(arylethynyl)imidazole skeleton displayed both solid-state and solution fluorescence, which remarkably changed on exposure to acid vapor.</p>

  • Access to Document (DOI)

• 5,12-Diacetyl-5,12-dihydroquinoxalino[2,3-b]quinoxalines: Solid-State Fluorescence, AIE Properties, and Orbital Switching by Substituent Effect

  Miura, Youhei, Yoshioka, Naoki

  CHEMISTRY-AN ASIAN JOURNAL (Chemistry - An Asian Journal)  13 ( 13 ) 1683 - 1687 2018.07

  Research paper (scientific journal),  ISSN  1861-4728

  　View Summary

  © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The compound 5,12-diacetyl-5,12-dihydroquinoxalino[2,3-b]quinoxaline 1 a and its derivatives were prepared, and their solid- and solution-state spectroscopic properties were studied; 1 a shows stronger fluorescence in solution than in the solid state due to aggregation caused by self-quenching. Phenyl- or alkoxy-substituted derivatives 1 b–d show solid-state fluorescence with moderate quantum yields of about Φ=0.12–0.15, although the corresponding values are 0.01–0.07 in solution. The spectroscopic properties of alkoxy-substituted derivatives were hardly changed compared to 1 a and 1 b, although 1 a and 1 b have similar absorption and fluorescence maxima in solution and in the solid state. DFT calculations indicate that orbital switching occurs between HOMO and HOMO-1 and HOMO-2 due to orbital interactions with introduced substituents. Crystal structure analysis revealed that the molecules have bent structures around tertiary nitrogen atoms and form a characteristic dimeric structure.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Investigation of the external stimuli-responsive organic fluorophore with imidazole skeleton

  Miura, Youhei

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2020

• Construction of active organic crystal with sheet-like structure

  Miura, Yohei

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2017

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• イミダゾジアザボロール骨格を持つ新奇有機ホウ素錯体の合成とその自己回復性メカノフルオロクロミズム

  毛利 匡佑,三浦 洋平,吉岡 直樹

  日本化学会 第103春季年会 (東京理科大学野田キャンパス) , 

  2023.03

  , 

  Oral presentation (general), 公益社団法人 日本化学会

• 4-アリールエチニル-5-ベンゾイル-1-メチルイミダゾ ール誘導体の自己回復性メカノフルオロクロミズム ならびにアモルファス状態における発光特性

  三浦 洋平,毛利 匡佑,吉岡 直樹

  第30回有機結晶シンポジウム (名古屋大学 野依記念学術交流館) , 

  2022.11

  , 

  Poster presentation, 公益社団法人 日本化学会 有機結晶部会

• 相転移を示さない5-Fluorobenzoyl-4-methoxyphenylethynyl-1-methylimidazole結晶のThermosalient効果

  三浦洋平, 武田貴志, 芥川智行, 吉岡 直樹

  日本化学会 第102春季年会, 

  2022.03

  , 

  Oral presentation (general)

• 長鎖置換基を導入した5-アリールエチニル-4-(2-ピリジルエチニル)イミダゾールの超分子形成と蛍光特性

  安藤直行, 村井一貴, 三浦洋平, 吉岡直樹

  日本化学会 第102春季年会, 

  2022.03

  , 

  Poster presentation

• 種々の置換基を導入した4-アリールエチニル-5-ベンゾイルイミダゾール誘導体の結晶で観測される自己回復性メカノフルオロクロミズム

  毛利匡佑, 三浦洋平, 吉岡直樹

  日本化学会 第102春季年会, 

  2022.03

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 小分子を利用した非π縮環型新奇機能性有機蛍光材料の開発

  2021.04

  -

  2024.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 三浦 洋平, Grant-in-Aid for Scientific Research (C), Principal investigator

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• SEMINAR IN APPLIED CHEMISTRY

  2024

• MATERIAL SCIENCE 3

  2024

• LABORATORIES IN SCIENCE AND TECHNOLOGY

  2024

• LABORATORIES IN APPLIED CHEMISTRY C

  2024

• FRONTIER OF CHEMISTRY

  2024

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• MATERIAL SCIENCE 3

  Keio University

  2022.04

  -

  2023.03

• CHEMISTRY B

  Keio University

  2022.04

  -

  2023.03

• CHEMISTRY B

  Keio University

  2021.04

  -

  2022.03

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本化学会, 

  2008

  -

  Present

• The Society of Physical Organic Chemistry, Japan

  　

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2023.04

  -

  2023.09

  The 9th International Conference on Nitroxide Radicals (SPIN-2023) Conference Secretariat

• 2022.04

  -

  2022.09

  第16回分子科学討論会2022実行委員

• 2021.08

  -

  2021.09

  第29回有機結晶シンポジウム実行委員

• 2016.05

  -

  2017.03

  会場・総務小委員会 委員, 日本化学会

• 2016.05

  -

  2017.03

  会場・総務小委員会 委員, 日本化学会

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