Fujimoto, Keiji

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry (Yagami)

Position

Professor

External Links
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Career 【 Display / hide 】

  • 1990.04
    -
    1996.03

    慶應義塾大学（理工学部） ,助手

  • 1994.09
    -
    1995.08

    米国マサチューセッツ州立大学訪問研究員

  • 1996.04
    -
    1999.03

    慶應義塾大学（理工学部） ,専任講師

  • 1999.04
    -
    2008.03

    慶應義塾大学（理工学部） ,助教授

  • 2000.04
    -
    2002.03

    大学院学習指導副主任（物質科学専攻）

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Academic Background 【 Display / hide 】

  • 1985.03

    Kyoto University, Faculty of Engineering, 高分子化学科

    University, Graduated

  • 1987.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Completed, Master's course

  • 1990.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 京都大学博士（工学）, Kyoto University, Coursework, 1993.03

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Licenses and Qualifications 【 Display / hide 】

  • 昭和６２年国家公務員採用１種, 1987

  • 昭和６３年国家公務員採用１種, 1988

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Composite materials and interfaces

  • Nanotechnology/Materials / Nanobioscience (Nano Materials/Nano Bioscience)

  • Nanotechnology/Materials / Polymer chemistry (Polymer Science and Engineering)

  • Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

  • Nanotechnology/Materials / Organic functional materials

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Research Keywords 【 Display / hide 】

  • Green particle

  • エコマテリアル

  • ソフトマテリアル

  • ドラッグデリバリーシステム

  • ナノコーティング

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Proposed Theme of Joint Research 【 Display / hide 】

  • リポナノカプセル

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

  • cosmetics

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

  • 微粒子組織体

  • 細胞表層改質

  • 組織マテリアル工学

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Books 【 Display / hide 】

  • 高分子微粒子の最新技術動向　高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

    藤本啓二、福井有香, シー・エム・シー, 2022.07

  • 高分子基礎ガイド

    藤本啓二、川口正剛、小泉智、福井有香、箕田雅彦、本柳仁, 朝倉書店, 2022.02,  Page： 153

  • 高分子微粒子のつくり方と活かし方

    藤本啓二、福井有香, 塗装工学 (一般社団法人）日本塗装技術協会) 54 ( 11 ) , 2019.11,  Page： 394 - 403

  • 高分子微粒子ハンドブック

    FUJIMOTO KEIJI, シーエムシー出版, 2017

    Scope: 高分子微粒子とは, 1-14

  • 高分子微粒子の創りかたと医用高分子への活かしかた

    FUJIMOTO KEIJI, 工業材料, 2017

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Papers 【 Display / hide 】

  • Preparation of a robust and degradable nanocapsule by polymer deposition over the liposome for loading and release of cargos

    Yuuka Fukui, Junna Ito, Masatoshi Takeiri, Keiji Fujimoto

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier B.V.)  676   132160 2023.11

    Research paper (scientific journal), Last author, Accepted,  ISSN  09277757

    　View Summary

    We prepared biobased nanocapsules by the polymer deposition over the ceramide-containing liposomes to render abilities to load versatile substances and to release them in response to enzymatic degradation of the capsule wall. First, we carried out phosphorylation of chitosan (CHI) to make it amphoteric. Then, we prepared a liposome containing glucosylceramide (GlcCer) and carried out deposition of phosphorylated chitosan (PCHI). The obtained capsule showed high structural stability against solubilization by surfactants and organic solvents, where it maintained its size even in 90 vol% DMSO. Next, we attempted to load various substances into the capsule. A lipophilic Nile red dissolved in 50 vol% DMSO could be loaded into the capsule without rupturing. The loading capacity of PCHI-deposited liposomes was almost three times higher than that of bare liposomes. Its release was suppressed to less than 10 % in an aqueous solution, whereas it could be released to more than 40 % when a small amount of surfactant was added to mimic a lipophilic environment. Also, an amphoteric nature of the capsule derived from PCHI allowed for loading of both cationic and anionic substances. Furthermore, lysozyme (Lyso) was deposited onto the capsule to provide the capsule wall with the enzymatic degradability. Although the release of substances from the capsule was suppressed to less than 10 % without Lyso, it was increased to approximately 50 % by enzymatic degradation of the PCHI layer.

  • One-pot generation of gold-polymer hybrid nanoparticles using a miniemulsion reactor system

    Fukui Y., Fujino K., Fujimoto K.

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids and Surfaces A: Physicochemical and Engineering Aspects)  666 2023.06

    ISSN  09277757

    　View Summary

    We investigated one-pot synthesis of gold nanoparticles (AuNPs) and AuNPs-polymer hybrid nanoparticles in a water-in-oil (W/O) miniemulsion. Water nanodroplets were dispersed as a reactor in cyclohexane using dimethicone as a surfactant. First, we intended to generate AuNPs in water nanodroplets, which contained HAuCl4 with a mixture of 1-vinylpyrrolidone (VP) and N,N’-methylenebisacrylamide (MBAAm). Several AuNPs with the size of approximately 10–20 nm were generated in each nanodroplet via reduction of AuCl4- by dimethicone. On the other hand, AuNPs was scarcely generated in water nanodroplets containing HAuCl4 with 2-hydroxyethyl methacrylate (HEMA). Next, we carried out polymerization in water nanodroplets to encapsulate AuNPs into polymer nanoparticles. Several AuNPs were encapsulated within polymer particles by copolymerization of VP and MBAAm with an oil-soluble initiator (V-601), and some AuNPs were present in the oil phase. The encapsulation efficiency of AuNPs was 34%. The encapsulation efficiency of AuNPs was dramatically increased by increasing the concentration of the initiator. The same result was obtained by increasing the concentration of the crosslinker due to rapid gelation of nanodroplets. On the other hand, monodisperse particles could be obtained by polymerization of HEMA using a water-soluble initiator (V-65). After polymerization for 5 d at 65ºC, the color of the suspension changed from opaque blue to blue purple and the encapsulation efficiency of AuNPs (5–20 nm) increased to 99 wt%. The average number of AuNPs encapsulated in a PHEMA nanoparticle increased from 1.5 to 4.6 particle. Furthermore, the size of AuNPs could be tuned by increasing the HAuCl4 concentration, and the corresponding color of the suspensions such as blue, purple, and red could be observed. The number and location of AuNPs in polymer nanoparticles could also be tuned by additives such as L-histidine and polyvinylpyrrolidone. By drop-casting the obtained hybrid nanoparticles, we could obtain gold-polymer hybrid films where AuNPs were evenly distributed within a film. The films exhibited different colors corresponding to their LSPR of AuNPs.

  • Control in Coloration and Estimation of the Refractive Index by Porous Polymeric Membranes Prepared by the "Miniemulsion" Templating Method

    Fukui Y., Sumida H., Sugaya Y., Fujimoto K.

    ACS Applied Polymer Materials (ACS Applied Polymer Materials)  4 ( 10 ) 7547 - 7553 2022.10

    ISSN  2637-6105

    　View Summary

    We fabricated porous polymeric membranes using the miniemulsion templating method to investigate the transmitted and scattered lights in terms of the Christiansen filter effect. This method made it possible to produce porous polymeric membranes with different refractive indices by polymerization of different monomers and copolymerization of monomers. When a membrane with an open-cellular structure was immersed in a liquid, the transmitted light was observed at a wavelength where the refractive indices of the polymeric phase and the liquid matched. Angle-independent color derived from the scattered light could also be observed. When the porous membrane of poly(2-ethylhexyl methacrylate) (EHMA) was immersed in a mixture of different kinds of liquids, the maximum wavelength of the transmission (λmax) changed according to the refractive index matching of the polymeric phase and the liquid, resulting in the change in coloration. Next, when the P(EHMA-co-EGDMA) membrane was immersed in a mixture of toluene and d-limonene, λmax and color varied depending on their mixing ratios. This coloration was controlled by temperature and the refractive indices of the polymeric phase and the liquid. Furthermore, we could estimate the refractive index of PEGDMA using λmax values obtained by immersing it into liquids with different refractive indices.

  • Functionalization of keratin nanoparticles by their internal modifications

    Yuuka Fukui, Kaori Ito, Keiji Fujimoto

    Polymer Journal (Springer Nature )  54 ( 11 ) 1367 - 1375 2022.06

    Joint Work, Last author, Accepted,  ISSN  00323896

    　View Summary

    We prepared keratin nanoparticles, which could respond to temperature and pH changes and to redox reactions, by electrostatic association of keratin and a cationic surfactant, dioctadecyl dimethyl ammonium chloride (DODAC). Solubilized keratin chains were assembled into nanoparticles (Ker-DODAC) and then crosslinked by disulfide formation. The resultant nanoparticles (Ker-DODACss) possessed a hydrophobic core composed of DODAC, enabling hydrophobic compounds to be loaed and retained in the core. By increasing the temperature, the fluidity of the core was increased, resulting in Ker-DODACss swelling and burst release of loaded compounds. Next, cholesterol was loaded into Ker-DODACss to modify the inner environment, such as the hydrophobicity and fluidity of the core. The nanoparticles (Ker-DODACss-Chol) exhibited reduced fluidity of the core and suppressed release of the payload. Furthermore, the release could be triggered by decreasing the electrostatic interaction between keratin and DODAC at pH values lower than 7.4. It was also found that Ker-DODACss-Chol possessed the ability to release payloads by breaking disulfide bonds. As a further internal modification, we incorporated a lipophilic antioxidant, α-tocopherol, into Ker-DODACss-Chol. It was confirmed that Ker-DODACss-Chol could act as a physical barrier to prevent α-tocopherol from undergoing oxidative degradation.

  • Preparation of a deformable nanocapsule by living radical polymerization in a liposome

    Fukui Y., Fukui A., Fujimoto K.

    Polymer Journal (Polymer Journal)  54 ( 7 ) 893 - 901 2022

    ISSN  00323896

    　View Summary

    We aimed to prepare an elastic nanocapsule by internal modification of a liposome with living radical polymerization. First, monomers and photoiniferters were encapsulated in liposomes. Then, UV light irradiation was used to conduct living radical polymerization in the liposomes. The obtained nanocapsules showed good absorption and retention of chemical substances depending on the binding ability to the incorporated polymers, and the absorption capacity could be controlled by the length and dissolved state of the polymer chains. In addition, dynamic morphological changes in the capsules were observed when liposomes with high membrane fluidity were employed. Morphological changes in the nanocapsules were induced by altering the pH value and ionic strength, resulting in the release of cargo in response to these environmental conditions.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ミニエマルションを用いた脂肪酸系ナノ油滴の作製と難水溶性薬剤の放出制御

    近藤 聡一郎, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  45回   162 - 162 2023.10

  • 糖タンパク質ムチンからなる環境応答性ナノ粒子の作製と機能化

    足立 理紗, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   116 - 116 2022.11

  • ミニエマルションを用いた脂肪酸系ナノ油滴の作製と薬剤の放出制御

    近藤 聡一郎, 瀬戸 隆継, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   400 - 400 2022.11

  • ミニエマルションを用いたゼラチンナノ粒子の創製と複合エマルション化による機能化

    三宅 佑里, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   399 - 399 2022.11

  • バイオポリマーを用いたジャイアントリポソーム集積化膜の作製

    青木 優美, 浅野 いぶき, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   332 - 332 2022.11

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Presentations 【 Display / hide 】

  • 重金属イオンの回収を目指した磁性体複合化ゲル微粒子の創製

    堀内文貴, 福井有香, 藤本啓二

    第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

  • 酵素固定化ゲル微粒子を用いた二酸化炭素から微小電流の発生

    田中裕一郎, 福井有香, 藤本啓二

    第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation, 高分子学会

  • ポリマー複合化ケラチンを用いた相変化材料(PCM)のカプセル化と潜熱蓄熱材への応用

    中熊茉莉, 福井有香, 藤本啓二

    第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

  • 液滴を反応場としたCNF由来グリーン微粒子の創製

    片岡三四郎, 福井有香, 藤本啓二

    第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

  • ゲル微粒子とペクチンを用いた粘着性コロイド構造体の作製

    小松賢治, 福井有香, 藤本啓二

    第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

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Works 【 Display / hide 】

  • 有機化学演習（高分子化学）

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 応用化学実験第２

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 自然科学実験（化学）

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 応用高分子化学

    FUJIMOTO KEIJI

    1996.04
    -
    1999.03
    , 

    Other, Single

  • 天然高分子

    FUJIMOTO KEIJI

    1999.04
    -
    2000.03
    , 

    Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

  • リポソームを鋳型とする中空ナノ粒子の作製方法

    Date applied： 特願2004-113635  2004.04 

    Patent, Joint

  • 天然高分子の複合粒子１

    Date applied： 特願2024-114767   

    Patent, Joint

  • 天然高分子の複合粒子２

    Date applied： 特願2024-196136   

    Patent, Joint

  • 天然高分子の複合粒子３

    Date applied： 特願2024-196135   

    Patent, Joint

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Awards 【 Display / hide 】

  • BEST POSTER PRIZE in 2010 MRS Fall Meeting

    FUJIMOTO KEIJI, 2010.12, MRS, Development of a particle nano-imprinting technique by core-shell particles

    Type of Award： International academic award (Japan or overseas)

  • スマートポリマー国際シンポジウム・ベストポスター賞

    藤本 啓二, 1998.06, スマートポリマー国際シンポジウム

  • 高分子学会研究奨励賞

    藤本 啓二, 1997.05, 高分子学会

  • 日本MRS学会研究奨励賞

    藤本 啓二, 1993.12, 日本MRS学会

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Courses Taught 【 Display / hide 】

  • SEMINAR IN APPLIED CHEMISTRY

    2024

  • POLYMER CHEMISTRY

    2024

  • LABORATORIES IN APPLIED CHEMISTRY D

    2024

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2024

  • GRADUATE RESEARCH ON FUNDAMENTAL SCIENCE AND TECHNOLOGY 2

    2024

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Courses Previously Taught 【 Display / hide 】

  • 高分子化学基礎

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 200people

  • バイオマテリアル特論

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 40people

  • 高分子化学

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 135people

  • 応用高分子化学

    慶應義塾大学

    2017.04
    -
    2018.03

  • 天然高分子

    Keio Univiersity

    1999.04
    -
    2000.03
    , 

    Spring Semester, Lecture, Within own ｆaculty

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Social Activities 【 Display / hide 】

  • バイオナノ粒子からミニエマルションを用いたグリーン微粒子と多孔質体の作製へ

    近畿化学協会重合工学部会, 近畿化学協会重合工学部会 令和 5 年度 重合工学レクチャーシリーズ No.10 (大阪科学技術センター)

    , 
    2024.01
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Media Coverage 【 Display / hide 】

  • 慶大　表面が硬い層のナノ粒子開発　歯・骨の欠損治療に応用へ

    日経産業新聞, 2018.01

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Memberships in Academic Societies 【 Display / hide 】

  • 高分子学会, 

    2011.04
    -
    Present

  • 日本バイオマテリアル学会, 

    2002
    -
    Present

  • 高分子学会機関誌「高分子」, 

    1997.06
    -
    1999.05

  • 日本DDS学会

    　
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Committee Experiences 【 Display / hide 】

  • 2011.04
    -
    Present

    代表会員, 高分子学会

  • 2002
    -
    Present

    評議委員, 日本バイオマテリアル学会

  • 1997.06
    -
    1999.05

    編集委員, 高分子学会機関誌「高分子」

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