Fujimoto, Keiji

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry （Yagami）

Position

Professor

External Links
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Career 【 Display / hide 】

  • 1990.04
    -
    1996.03

    慶應義塾大学（理工学部） ,助手

  • 1994.09
    -
    1995.08

    米国マサチューセッツ州立大学訪問研究員

  • 1996.04
    -
    1999.03

    慶應義塾大学（理工学部） ,専任講師

  • 1999.04
    -
    2008.03

    慶應義塾大学（理工学部） ,助教授

  • 2000.04
    -
    2002.03

    大学院学習指導副主任（物質科学専攻）

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Academic Background 【 Display / hide 】

  • 1985.03

    Kyoto University, Faculty of Engineering, 高分子化学科

    University, Graduated

  • 1987.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Completed, Master's course

  • 1990.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 京都大学博士（工学）, Kyoto University, Coursework, 1993.03

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Licenses and Qualifications 【 Display / hide 】

  • 昭和６２年国家公務員採用１種, 1987

  • 昭和６３年国家公務員採用１種, 1988

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Composite materials and interfaces

  • Nanotechnology/Materials / Nanobioscience (Nano Materials/Nano Bioscience)

  • Nanotechnology/Materials / Polymer chemistry (Polymer Science and Engineering)

  • Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

  • Nanotechnology/Materials / Organic functional materials

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Research Keywords 【 Display / hide 】

  • エコマテリアル

  • ソフトマテリアル

  • ドラッグデリバリーシステム

  • ナノコーティング

  • バイオベースポリマー

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Proposed Theme of Joint Research 【 Display / hide 】

  • リポナノカプセル

  • 微粒子組織体

  • 細胞表層改質

  • 組織マテリアル工学

  • 高分子ゲル粒子の作製と機能化

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Books 【 Display / hide 】

  • 高分子微粒子の最新技術動向　高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

    シー・エム・シー, 2022.07

  • 高分子基礎ガイド

    藤本啓二、川口正剛、小泉智、福井有香、箕田雅彦、本柳仁, 朝倉書店, 2022.02,  Page： 153

  • 高分子微粒子のつくり方と活かし方

    藤本啓二、福井有香, 塗装工学 (一般社団法人）日本塗装技術協会) 54 ( 11 ) , 2019.11,  Page： 394 - 403

  • 高分子微粒子ハンドブック

    FUJIMOTO KEIJI, シーエムシー出版, 2017

    Scope: 高分子微粒子とは, 1-14

  • 高分子微粒子の創りかたと医用高分子への活かしかた

    FUJIMOTO KEIJI, 工業材料, 2017

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Papers 【 Display / hide 】

  • Functionalization of keratin nanoparticles by their internal modifications

    Yuuka Fukui, Kaori Ito, Keiji Fujimoto

    Polymer Journal （Springer Nature )   2022.06

    Joint Work, Last author, Accepted,  ISSN  00323896

    　View Summary

    We prepared keratin nanoparticles, which could respond to temperature and pH changes and to redox reactions, by electrostatic association of keratin and a cationic surfactant, dioctadecyl dimethyl ammonium chloride (DODAC). Solubilized keratin chains were assembled into nanoparticles (Ker-DODAC) and then crosslinked by disulfide formation. The resultant nanoparticles (Ker-DODACss) possessed a hydrophobic core composed of DODAC, enabling hydrophobic compounds to be loaed and retained in the core. By increasing the temperature, the fluidity of the core was increased, resulting in Ker-DODACss swelling and burst release of loaded compounds. Next, cholesterol was loaded into Ker-DODACss to modify the inner environment, such as the hydrophobicity and fluidity of the core. The nanoparticles (Ker-DODACss-Chol) exhibited reduced fluidity of the core and suppressed release of the payload. Furthermore, the release could be triggered by decreasing the electrostatic interaction between keratin and DODAC at pH values lower than 7.4. It was also found that Ker-DODACss-Chol possessed the ability to release payloads by breaking disulfide bonds. As a further internal modification, we incorporated a lipophilic antioxidant, α-tocopherol, into Ker-DODACss-Chol. It was confirmed that Ker-DODACss-Chol could act as a physical barrier to prevent α-tocopherol from undergoing oxidative degradation.

  • Preparation of a deformable nanocapsule by living radical polymerization in a liposome

    Fukui Y., Fukui A., Fujimoto K.

    Polymer Journal （Polymer Journal)   2022

    ISSN  00323896

    　View Summary

    We aimed to prepare an elastic nanocapsule by internal modification of a liposome with living radical polymerization. First, monomers and photoiniferters were encapsulated in liposomes. Then, UV light irradiation was used to conduct living radical polymerization in the liposomes. The obtained nanocapsules showed good absorption and retention of chemical substances depending on the binding ability to the incorporated polymers, and the absorption capacity could be controlled by the length and dissolved state of the polymer chains. In addition, dynamic morphological changes in the capsules were observed when liposomes with high membrane fluidity were employed. Morphological changes in the nanocapsules were induced by altering the pH value and ionic strength, resulting in the release of cargo in response to these environmental conditions.

  • Preparation of agarose xerogel nanoparticles by solvent evaporation from water nanodroplets

    Yuuka Fukui, Ryutaro Inamura & Keiji Fujimoto

    Polymer Journal （Springer Nature)  53 （ 7 ） 815 - 821 2021.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  00323896

    　View Summary

    We developed a W/O miniemulsion reactor system enabling the preparation of biopolymer nanoparticles and control of their morphologies and inner microstructures. First, the W/O miniemulsion was prepared by suspending water nanodroplets containing agarose in oil. Then, we produced agarose hydrogel nanoparticles (AgarH) by the gelation of agarose in nanodroplets. Next, we prepared agarose xerogel nanoparticles (AgarX) by precisely tuning the water evaporation from AgarH. We controlled the morphologies (solid and hollow) and crystal structure of AgarX by changing the pressure and temperature during water evaporation. In fact, AgarX with a hollow structure was generated through rapid evaporation at a low pressure. AgarH was dissolved in Milli-Q water when the temperature was raised to 90 °C. On the other hand, AgarX remained a solid particle under the same conditions, likely because of its high crystallinity. We expect that this technique can be applied to prepare xerogels of diverse biomass-based polymers for the replacement of synthetic polymers.

  • Creation of porous polymeric membranes by accumulation of water nanodroplets in a miniemulsion system

    Fukui Y., Fujino R., Sugaya Y., Fujimoto K.

    Polymer Journal （Polymer Journal)  52 （ 9 ） 1077 - 1083 2020.05

    Research paper (scientific journal), Accepted,  ISSN  00323896

    　View Summary

    © 2020, The Society of Polymer Science, Japan. We developed a miniemulsion templating method to prepare porous polymeric membranes. First, water nanodroplets were suspended in an oil phase by using a nonionic and polymeric surfactant to form a water-in-oil (W/O) miniemulsion. After the nanodroplets accumulated by centrifugation, a small amount of monomer was added as an oil phase to resuspend the water nanodroplets in a monomer phase. Then, photopolymerization of the monomer phase was conducted to generate pores in the polymeric matrix. The size of the nanodroplets was tuned by the surfactant concentration to control the pore size of the membranes. We could produce pore morphologies such as closed-cellular, open-cellular, and bicontinuous structures by tuning the volume fraction of the nanodroplets. Alternatively, nanodroplets were accumulated by centrifugation, and then further surfactants were added to the monomer to suppress the coalescence of nanodroplets. This enabled us to generate a highly porous open-cellular structure while maintaining the size and spherical shape. Next, HAuCl4 was reduced by using the surfactant displayed at the inner surface of the pore wall as the reducing agent. Gold nanoparticles were produced in the inner pores of the polymeric membrane, showing coloration derived from local surface plasmon resonance.

  • Tuning of particle indentation by surface modification of polymer particles and substrates

    Fukui Y., Yamamoto K., Yamamoto T., Fujimoto K.

    Colloids and Surfaces A: Physicochemical and Engineering Aspects （Colloids and Surfaces A: Physicochemical and Engineering Aspects)  588 2020.03

    Research paper (scientific journal), Accepted,  ISSN  09277757

    　View Summary

    © 2019 Elsevier B.V. We studied the influence of the chemical properties of the polymer particle and the polymer substrate on particle indentation. The polymer particles were arrayed over the polymer substrate and heat treatment (annealing) was conducted above the glass transition temperature (Tg) of bulk polymer to indent polymer particles into the polymer substrate. Surface topologies of particle-indented surfaces were observed with a field-emission scanning electron microscope (FE-SEM) and the degree of particle indentation (DI) was evaluated with a scanning probe microscope (SPM). The particle-arrayed substrate was placed upside down and then heat treatment was carried out. It was found that there was no effect of gravity on particle indentation. To prepare polymer particles with different chemical properties, surface grafting of hydrophobic, hydrophilic, cationic and anionic polymer chains was carried out by iniferter-initiated living radical polymerization. We found that the indentation of these particles was influenced by the outermost surface of the particle. Next, to investigate the effect of the substrate surface on particle indentation, sulfonation of the polystyrene (PS) substrate was carried out with concentrated sulfuric acid. We found that the surface property of the substrate also influenced particle indentation. From these results, we concluded that particle indentation would be determined by the interaction between the particle surface and the substrate surface. Finally, we intended to analyze the viscoelastic property of the substrate surface by particle indentation. We could estimate Tg values of PS and polyvinyl chloride (PVC) substrates by observing the particle indentation at the different annealing temperatures.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • カテコール固定化ペクチンを用いたゲル粒子の作製と付着性評価

    高林 輝, 南 裕之, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  41回   552 - 552 2019.11

  • リン酸化キトサンとリゾチームを積層させたリポナノカプセルの酵素分解による機能発現

    奈須 万柚子, 多部田 郁絵, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  41回   492 - 492 2019.11

  • リポソームの内部におけるポリマー生成と機能性カプセルの創製

    福井 有彩, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  41回   257 - 257 2019.11

  • ケラチンからなるナノ粒子の作製と内部改質による機能付与

    伊藤 香, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  41回   256 - 256 2019.11

  • グラフト化タンパク質を用いたゲル材料の表面改質

    野田 百恵, 徳生 ひかる, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  41回   545 - 545 2019.11

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Presentations 【 Display / hide 】

  • 酵素の連鎖反応を用いたゲル微粒子への炭酸カルシウムの複合化

    落合達也、福井有香、藤本啓二

    第29回高分子ゲル研究討論会 (東工大、大岡山) , 

    2018.01
    , 

    Oral presentation (general), 高分子学会

  • PHEMA微粒子をコアとする重合型および積層型表面層の構築

    兼森智規、福井有香、藤本啓二

    第29回高分子ゲル研究討論会 (東工大、大岡山) , 

    2018.01
    , 

    Poster presentation, 高分子学会

  • コアシェル型粒子を用いた中空ゲル粒子の作製

    栗原俊介、福井有香、藤本啓二

    第29回高分子ゲル研究討論会 (東工大、大岡山) , 

    2018.01
    , 

    Oral presentation (general), 高分子学会

  • ポリマー積層化リポソーム（リポナノカプセル）の酵素分解による機能発現

    大塚日加里、福井有香、藤本啓二

    日本バイオマテリアル学会シンポジウム2017 (タワーホール船堀) , 

    2017.11
    , 

    Oral presentation (general), 日本バイオマテリアル学会

  • W/Oミニエマルションにおけるナノ水滴を反応場としたリン酸カルシウム複合化高分子微粒子の作製

    高林浩平、福井有香、藤本啓二

    第26回ポリマー材料フォーラム (大阪国際交流センター) , 

    2017.11
    , 

    Poster presentation, 高分子学会

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Works 【 Display / hide 】

  • 有機化学演習（高分子化学）

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 応用化学実験第２

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 自然科学実験（化学）

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 応用高分子化学

    FUJIMOTO KEIJI

    1996.04
    -
    1999.03
    , 

    Other, Single

  • 天然高分子

    FUJIMOTO KEIJI

    1999.04
    -
    2000.03
    , 

    Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

  • リポソームを鋳型とする中空ナノ粒子の作製方法

    Date applied： 特願2004-113635  2004.04 

    Patent, Joint

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Awards 【 Display / hide 】

  • BEST POSTER PRIZE in 2010 MRS Fall Meeting

    FUJIMOTO KEIJI, 2010.12, MRS, Development of a particle nano-imprinting technique by core-shell particles

    Type of Award： International academic award (Japan or overseas)

  • スマートポリマー国際シンポジウム・ベストポスター賞

    藤本 啓二, 1998.06, スマートポリマー国際シンポジウム

  • 高分子学会研究奨励賞

    藤本 啓二, 1997.05, 高分子学会

  • 日本MRS学会研究奨励賞

    藤本 啓二, 1993.12, 日本MRS学会

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Other 【 Display / hide 】

  • 2018年01月

    　View Details

    慶大　表面が硬い層のナノ粒子開発　歯・骨の欠損治療に応用へ、日経産業新聞

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Courses Taught 【 Display / hide 】

  • SEMINAR IN APPLIED CHEMISTRY

    2022

  • REGENERATION BIOLOGY

    2022

  • POLYMER CHEMISTRY

    2022

  • LABORATORIES IN APPLIED CHEMISTRY D

    2022

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2022

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Courses Previously Taught 【 Display / hide 】

  • 高分子化学基礎

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 200people

  • バイオマテリアル特論

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 40people

  • 高分子化学

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 135people

  • 応用高分子化学

    慶應義塾大学

    2017.04
    -
    2018.03

  • 天然高分子

    Keio Univiersity

    1999.04
    -
    2000.03
    , 

    Spring Semester, Lecture, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

  • 高分子学会, 

    2011.04
    -
    Present

  • 日本バイオマテリアル学会, 

    2002
    -
    Present

  • 高分子学会機関誌「高分子」, 

    1997.06
    -
    1999.05

  • 日本DDS学会

    　
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Committee Experiences 【 Display / hide 】

  • 2011.04
    -
    Present

    代表会員, 高分子学会

  • 2002
    -
    Present

    評議委員, 日本バイオマテリアル学会

  • 1997.06
    -
    1999.05

    編集委員, 高分子学会機関誌「高分子」

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