Fujimoto, Keiji

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry ( Yagami )

Position

Professor

External Links

Career 【 Display / hide 】

  • 1990.04
    -
    1996.03

    慶應義塾大学（理工学部） ,助手

  • 1994.09
    -
    1995.08

    米国マサチューセッツ州立大学訪問研究員

  • 1996.04
    -
    1999.03

    慶應義塾大学（理工学部） ,専任講師

  • 1999.04
    -
    2008.03

    慶應義塾大学（理工学部） ,助教授

  • 2000.04
    -
    2002.03

    大学院学習指導副主任（物質科学専攻）

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Academic Background 【 Display / hide 】

  • 1985.03

    Kyoto University, Faculty of Engineering, 高分子化学科

    University, Graduated

  • 1987.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Completed, Master's course

  • 1990.03

    Kyoto University, 工学部工学研究科, 高分子化学専攻

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 京都大学博士（工学）, Kyoto University, Coursework, 1993.03

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Licenses and Qualifications 【 Display / hide 】

  • 昭和６２年国家公務員採用１種, 1987

  • 昭和６３年国家公務員採用１種, 1988

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Composite materials and interfaces

  • Nanotechnology/Materials / Nanobioscience (Nano Materials/Nano Bioscience)

  • Nanotechnology/Materials / Polymer chemistry (Polymer Science and Engineering)

  • Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

  • Nanotechnology/Materials / Organic functional materials

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Research Keywords 【 Display / hide 】

  • Green particle

  • エコマテリアル

  • ソフトマテリアル

  • ドラッグデリバリーシステム

  • ナノコーティング

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Proposed Theme of Joint Research 【 Display / hide 】

  • リポナノカプセル

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

  • cosmetics

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

  • 微粒子組織体

  • 細胞表層改質

  • 組織マテリアル工学

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Books 【 Display / hide 】

  • 高分子微粒子の最新技術動向　高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

    藤本啓二、福井有香, シー・エム・シー, 2022.07

  • 高分子基礎ガイド

    藤本啓二、川口正剛、小泉智、福井有香、箕田雅彦、本柳仁, 朝倉書店, 2022.02,  Page： 153

  • 高分子微粒子のつくり方と活かし方

    藤本啓二、福井有香, 塗装工学 (一般社団法人）日本塗装技術協会) 54 ( 11 ) , 2019.11,  Page： 394 - 403

  • 高分子微粒子ハンドブック

    FUJIMOTO KEIJI, シーエムシー出版, 2017

    Scope: ポリマー鎖の会合によって微粒子を作る, 114-121

  • 高分子微粒子ハンドブック

    FUJIMOTO KEIJI, シーエムシー出版, 2017

    Scope: 高分子微粒子とは, 1-14

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Papers 【 Display / hide 】

  • Suspension of liposome-based nanocapsules in organic solvents via surface acetylation of chitosan-deposited liposomes.

    Mihara T, Fukui Y, Fujimoto K

    Colloids and surfaces. B, Biointerfaces 259   115346 2025.12

    ISSN  0927-7765

  • Core-shell Particle Embedding into Human Hair: A Novel Approach for Surface Modification and Long-Lasting Hair Coloration

    Fujimoto K., Nishimura M., Fukui Y.

    ACS Omega (ACS)  10 ( 20 ) 20585 - 20592 2025.05

    Research paper (scientific journal), Joint Work, Lead author,  ISSN  2470-1343

    　View Summary

    To embed particles into human hair, core-shell (CS) particles were prepared by seeded emulsion polymerization and were arrayed to the surface of natural hair via dip coating. The particle-coated natural hair was treated at various temperatures in a controlled environment with a relative humidity of 5% (5% RH). No particle embedding was observed at 25 °C. However, the degree of particle embedding (DE) slightly increased at 50 °C and substantially at 150 °C. At 100% RH, embedding was effectively achieved at 50 °C, probably because the adsorbed water acted as a plasticizer, softening the hair. Bleached hair exhibited a significant reduction in surface wettability, whereas the DE of CS particles remained comparable to that of natural hair, indicating that surface wettability does not affect the particle embedding process. On the other hand, hair treated with a reducing agent displayed a notable increase in the DE, reaching approximately 20% even at 25 °C and increasing to 35% at 150 °C. At 100% RH, DE values dramatically increased to approximately 35%, even at 25 °C. Sudan Black B was incorporated into the CS particles to produce stained particles (CS(B) particles). This staining process enabled the coloration of bleached hair by arranging and embedding CS(B) particles. Visual observation confirmed uniform coloration of the hair samples. The color difference (ΔE*) results strongly indicated that bleached hair could be effectively dyed with CS(B) particles. Additionally, the color of CS(B) particle-embedded hair remained stable after ultrasonication, demonstrating that particle embedding ensures long-lasting hair coloration by securely embedding the stained particles within the hair samples.

  • Preparation of a CNF porous membrane and in situ synthesis of silver nanoparticles (AgNPs)

    Fukui Y., Baba E., Fujimoto K.

    RSC Advances 15 ( 2 ) 1115 - 1124 2025.01

    　View Summary

    We prepared a cellulose nanofiber (CNF)-based porous membrane with three dimensional cellular structures. CNF was concentrated via a surfactant-induced assembly by mixing CNF with a cationic surfactant, domiphen bromide (DB). Furthermore, they were accumulated by centrifugation to obtain a CNF-DB sol. Next, when the CNF-DB sol was naturally dried, a membrane composed of densely packed CNF was obtained. On the other hand, when the CNF-DB sol was freeze-dried, a porous membrane with the anisotropic cellular structure could be obtained. The interspace between layered CNF sheets was tunable by the DB concentration in the assembly process and the centrifugal force in the accumulation process. FT-IR analysis of the porous membrane showed the formation of hydrogen bonds between the CNF, resulting in facilitation of crosslinking of the CNF and formation of the cellular structures. The obtained CNF-DB membrane exhibited high water resistance. They showed a high ability to absorb hydrophobic dyes such as Nile red and rhodamine B (RhB) due to the presence of the hydrophobic core of DB micelles. Then, the release of RhB could be controlled by the ionic strength in the medium. In addition, they possessed a high ability to adsorb cationic metals such as Ag ions due to the presence of carboxyl moieties of CNF. Next, in situ synthesis of silver nanoparticles (AgNPs) was carried out by employing the CNF-DB membrane as a template for Ag ion adsorption and reduction. Deposition of AgNPs could be observed on the CNF-DB membrane, which suppressed aggregation of AgNPs. Almost all AgNPs were arrayed apart from each other to generate the hotspots, which could enhance surface-enhanced Raman scattering (SERS) of AgNPs. Such an AgNPs-CNF composite membrane could be applied for a label-free analysis of adsorbed RhB.

  • Preparation of a robust and degradable nanocapsule by polymer deposition over the liposome for loading and release of cargos

    Yuuka Fukui, Junna Ito, Masatoshi Takeiri, Keiji Fujimoto

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier B.V.)  676   132160 2023.11

    Research paper (scientific journal), Last author, Accepted,  ISSN  09277757

    　View Summary

    We prepared biobased nanocapsules by the polymer deposition over the ceramide-containing liposomes to render abilities to load versatile substances and to release them in response to enzymatic degradation of the capsule wall. First, we carried out phosphorylation of chitosan (CHI) to make it amphoteric. Then, we prepared a liposome containing glucosylceramide (GlcCer) and carried out deposition of phosphorylated chitosan (PCHI). The obtained capsule showed high structural stability against solubilization by surfactants and organic solvents, where it maintained its size even in 90 vol% DMSO. Next, we attempted to load various substances into the capsule. A lipophilic Nile red dissolved in 50 vol% DMSO could be loaded into the capsule without rupturing. The loading capacity of PCHI-deposited liposomes was almost three times higher than that of bare liposomes. Its release was suppressed to less than 10 % in an aqueous solution, whereas it could be released to more than 40 % when a small amount of surfactant was added to mimic a lipophilic environment. Also, an amphoteric nature of the capsule derived from PCHI allowed for loading of both cationic and anionic substances. Furthermore, lysozyme (Lyso) was deposited onto the capsule to provide the capsule wall with the enzymatic degradability. Although the release of substances from the capsule was suppressed to less than 10 % without Lyso, it was increased to approximately 50 % by enzymatic degradation of the PCHI layer.

  • One-pot generation of gold-polymer hybrid nanoparticles using a miniemulsion reactor system

    Fukui Y., Fujino K., Fujimoto K.

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids and Surfaces A: Physicochemical and Engineering Aspects)  666 2023.06

    ISSN  09277757

    　View Summary

    We investigated one-pot synthesis of gold nanoparticles (AuNPs) and AuNPs-polymer hybrid nanoparticles in a water-in-oil (W/O) miniemulsion. Water nanodroplets were dispersed as a reactor in cyclohexane using dimethicone as a surfactant. First, we intended to generate AuNPs in water nanodroplets, which contained HAuCl4 with a mixture of 1-vinylpyrrolidone (VP) and N,N’-methylenebisacrylamide (MBAAm). Several AuNPs with the size of approximately 10–20 nm were generated in each nanodroplet via reduction of AuCl4- by dimethicone. On the other hand, AuNPs was scarcely generated in water nanodroplets containing HAuCl4 with 2-hydroxyethyl methacrylate (HEMA). Next, we carried out polymerization in water nanodroplets to encapsulate AuNPs into polymer nanoparticles. Several AuNPs were encapsulated within polymer particles by copolymerization of VP and MBAAm with an oil-soluble initiator (V-601), and some AuNPs were present in the oil phase. The encapsulation efficiency of AuNPs was 34%. The encapsulation efficiency of AuNPs was dramatically increased by increasing the concentration of the initiator. The same result was obtained by increasing the concentration of the crosslinker due to rapid gelation of nanodroplets. On the other hand, monodisperse particles could be obtained by polymerization of HEMA using a water-soluble initiator (V-65). After polymerization for 5 d at 65ºC, the color of the suspension changed from opaque blue to blue purple and the encapsulation efficiency of AuNPs (5–20 nm) increased to 99 wt%. The average number of AuNPs encapsulated in a PHEMA nanoparticle increased from 1.5 to 4.6 particle. Furthermore, the size of AuNPs could be tuned by increasing the HAuCl4 concentration, and the corresponding color of the suspensions such as blue, purple, and red could be observed. The number and location of AuNPs in polymer nanoparticles could also be tuned by additives such as L-histidine and polyvinylpyrrolidone. By drop-casting the obtained hybrid nanoparticles, we could obtain gold-polymer hybrid films where AuNPs were evenly distributed within a film. The films exhibited different colors corresponding to their LSPR of AuNPs.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Development of Multi-Functional Nanocapsules by Surface and Inner Modifications of Liposomes with Polymers

    藤本啓二、福井有香

    月刊ファインケミカル ((株)シーエムシー出版)   2025.05

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Corresponding author

  • ミニエマルションを用いた脂肪酸系ナノ油滴の作製と難水溶性薬剤の放出制御

    近藤 聡一郎, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  45回   162 - 162 2023.10

  • バイオポリマーを用いたジャイアントリポソーム集積化膜の作製

    青木 優美, 浅野 いぶき, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   332 - 332 2022.11

  • 糖タンパク質ムチンからなる環境応答性ナノ粒子の作製と機能化

    足立 理紗, 福井 有香, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   116 - 116 2022.11

  • 多糖と酵素を積層化したセラミド含有リポナノカプセルの創製とポリマー層への物質封入

    伊藤 純名, 福井 有香, 竹入 雅敏, 畑山 晃輝, 木村 吉秀, 藤本 啓二

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   115 - 115 2022.11

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Presentations 【 Display / hide 】

  • 重金属イオンの回収を目指した磁性体複合化ゲル微粒子の創製

    堀内文貴, 福井有香, 藤本啓二

    [Domestic presentation]  第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

  • 酵素固定化ゲル微粒子を用いた二酸化炭素から微小電流の発生

    田中裕一郎, 福井有香, 藤本啓二

    [Domestic presentation]  第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation, 高分子学会

  • ポリマー複合化ケラチンを用いた相変化材料(PCM)のカプセル化と潜熱蓄熱材への応用

    中熊茉莉, 福井有香, 藤本啓二

    [Domestic presentation]  第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

  • 液滴を反応場としたCNF由来グリーン微粒子の創製

    片岡三四郎, 福井有香, 藤本啓二

    [Domestic presentation]  第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

  • ゲル微粒子とペクチンを用いた粘着性コロイド構造体の作製

    小松賢治, 福井有香, 藤本啓二

    [Domestic presentation]  第32回ポリマー材料フォーラム, 

    2023.11
    -
    2023.12
    , 

    Poster presentation

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Works 【 Display / hide 】

  • 有機化学演習（高分子化学）

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 応用化学実験第２

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 自然科学実験（化学）

    FUJIMOTO KEIJI

    1991.04
    -
    Present
    , 

    Other, Joint

  • 応用高分子化学

    FUJIMOTO KEIJI

    1996.04
    -
    1999.03
    , 

    Other, Single

  • 天然高分子

    FUJIMOTO KEIJI

    1999.04
    -
    2000.03
    , 

    Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

  • リポソームを鋳型とする中空ナノ粒子の作製方法

    Date applied： 特願2004-113635  2004.04 

    Patent, Joint

  • 脂質二重膜とナノサイズ蛍光体複合体

    Date applied： 特願2003-410841  2003.12 

    Patent, Joint

  • ポリマー微粒子を用いる無機又は有機物質構造体の成長・形成方法

    Date applied： 特願2002-268034   

    Patent

  • 表面異方性高分子微粒子および製造方法

    Date applied： 特開平10-87841   

    Date issued： 平成８特許願第２４２４０４号  2004.06

    Patent, Joint

  • 一次元鎖状超構造体及びその製造方法

    Date applied： 特開2002-327069   

    Patent

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Awards 【 Display / hide 】

  • BEST POSTER PRIZE in 2010 MRS Fall Meeting

    FUJIMOTO KEIJI, 2010.12, MRS, Development of a particle nano-imprinting technique by core-shell particles

    Type of Award： International academic award (Japan or overseas)

  • スマートポリマー国際シンポジウム・ベストポスター賞

    藤本 啓二, 1998.06, スマートポリマー国際シンポジウム

  • 高分子学会研究奨励賞

    藤本 啓二, 1997.05, 高分子学会

  • 日本MRS学会研究奨励賞

    藤本 啓二, 1993.12, 日本MRS学会

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Courses Taught 【 Display / hide 】

  • GRADUATE RESEARCH ON FUNDAMENTAL SCIENCE AND TECHNOLOGY 2

    2025

  • GRADUATE RESEARCH ON FUNDAMENTAL SCIENCE AND TECHNOLOGY 1

    2025

  • FUNDAMENTAL POLYMER CHEMISTRY

    2025

  • BACHELOR'S THESIS

    2025

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2025

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Courses Previously Taught 【 Display / hide 】

  • 高分子化学基礎

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 200people

  • バイオマテリアル特論

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 40people

  • 高分子化学

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 135people

  • 応用高分子化学

    慶應義塾大学

    2017.04
    -
    2018.03

  • 天然高分子

    Keio Univiersity

    1999.04
    -
    2000.03
    , 

    Spring Semester, Lecture, Within own ｆaculty

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Social Activities 【 Display / hide 】

  • バイオナノ粒子からミニエマルションを用いたグリーン微粒子と多孔質体の作製へ

    近畿化学協会重合工学部会, 近畿化学協会重合工学部会 令和 5 年度 重合工学レクチャーシリーズ No.10 (大阪科学技術センター)

    , 
    2024.01
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Media Coverage 【 Display / hide 】

  • 慶大　表面が硬い層のナノ粒子開発　歯・骨の欠損治療に応用へ

    日経産業新聞, 2018.01

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Memberships in Academic Societies 【 Display / hide 】

  • 高分子学会, 

    2011.04
    -
    Present

  • 日本バイオマテリアル学会, 

    2002
    -
    Present

  • American Chemcal Society, 

    1998.04
    -
    Present

  • 繊維学会, 

    1991
    -
    Present

  • 日本DDS学会

    　
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Committee Experiences 【 Display / hide 】

  • 2023.04
    -
    Present

    医用高分子研究会アドバイザー

  • 2011.04
    -
    Present

    代表会員, 高分子学会

  • 2002
    -
    2025.03

    評議委員, 日本バイオマテリアル学会

  • 1997.06
    -
    1999.05

    編集委員, 高分子学会機関誌「高分子」

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