KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1990.04

  -

  1996.03

  慶應義塾大学（理工学部） ,助手

• 1994.09

  -

  1995.08

  米国マサチューセッツ州立大学訪問研究員

• 1996.04

  -

  1999.03

  慶應義塾大学（理工学部） ,専任講師

• 1999.04

  -

  2008.03

  慶應義塾大学（理工学部） ,助教授

• 2000.04

  -

  2002.03

  大学院学習指導副主任（物質科学専攻）

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1985.03

  Kyoto University, Faculty of Engineering, 高分子化学科

  University, Graduated

• 1987.03

  Kyoto University, 工学部工学研究科, 高分子化学専攻

  Graduate School, Completed, Master's course

• 1990.03

  Kyoto University, 工学部工学研究科, 高分子化学専攻

  Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 京都大学博士（工学）, Kyoto University, Coursework, 1993.03

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 昭和６２年国家公務員採用１種, 1987

• 昭和６３年国家公務員採用１種, 1988

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Nanotechnology/Materials / Composite materials and interfaces

• Nanotechnology/Materials / Nanobioscience (Nano Materials/Nano Bioscience)

• Nanotechnology/Materials / Polymer chemistry (Polymer Science and Engineering)

• Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

• Nanotechnology/Materials / Organic functional materials

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Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Green particle

• エコマテリアル

• ソフトマテリアル

• ドラッグデリバリーシステム

• ナノコーティング

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Proposed Theme of Joint Research 【 Display / hide 】

Proposed Theme of Joint Research 【 Display / hide 】

• リポナノカプセル

  Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

• cosmetics

  Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research

• 微粒子組織体

• 細胞表層改質

• 組織マテリアル工学

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Books 【 Display / hide 】

Books 【 Display / hide 】

• 高分子微粒子の最新技術動向　高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

  藤本啓二、福井有香, シー・エム・シー, 2022.07

  Contact page： 11-19

• 高分子基礎ガイド

  藤本啓二、川口正剛、小泉智、福井有香、箕田雅彦、本柳仁, 朝倉書店, 2022.02

  • CiNii Research

• ドラッグデリバリーシステム　リポソームの表面改質によるナノカプセルの作製と機能化

  福井有香、藤本啓二, シーエムシー出版, 2018.06

  Contact page： 195-206

• 高分子微粒子ハンドブック　高分子微粒子とは

  藤本 啓二, シーエムシー出版, 2017.07

  Scope: 高分子微粒子とは,  Contact page： 1-14

• 高分子微粒子ハンドブック　コアシェル微粒子の作製と機能化

  藤本 啓二, シーエムシー出版, 2017.07

  Contact page： 167-175

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Suspension of liposome-based nanocapsules in organic solvents via surface acetylation of chitosan-deposited liposomes.

  Mihara T, Fukui Y, Fujimoto K

  Colloids and surfaces. B, Biointerfaces (Elsevier)  259   115346 2026.03

  Research paper (scientific journal), Joint Work, Last author, Accepted,  ISSN  0927-7765

  　View Summary

  Liposomes are valuable drug and cosmetic carriers but face limitations in stability and active loading from external phases. Polymer-coated liposomes (liponanocapsules) have improved robustness, and this study advances the approach by acetylating chitosan-coated liposomes to form chitin-deposited capsules, leveraging chitin's biocompatibility and insolubility to enhance the structural and colloidal stability in organic solvents and oils. This represents the first report of suspensions of liposome-based capsules in such media. Anionic liposomes prepared from dilauroyl phosphatidyl acid acquire a hydrodynamic diameter increase from 100 to 190 nm and shift in ζ-potential from negative to positive upon chitosan deposition. Surface acetylation of the deposited chitosan with sodium acetate and a condensing agent yields chitin-deposited liposomes (Lipo[-]-chitin), with the degree of acetylation (DA) controlled by changing the reagent concentration. Lipo[-]-chitin shows a shift in the phase transition of the lipid membrane to a higher temperature owing to the suppression of lipid fluidity, suggesting that the capsules become rigid and robust. The hydrodynamic diameter of Lipo[-]-chitin in water increases with the DA because of capsule aggregation. By contrast, Lipo[-]-chitin becomes smaller in mixtures of water and water-miscible organic solvents, such as dimethyl sulfoxide (DMSO), ethanol, and acetone, indicating a positive impact of acetylation on the colloidal stability. In mixtures of water with DMSO or ethanol, a higher DA reduces the colloidal stability, whereas the opposite trend is observed in acetone. These results indicate that the colloidal stability of the acetylated capsules is strongly governed by the DA. Notably, Lipo[-]-chitin with a higher DA can be suspended in 100 % ethanol without aggregation or rupture. The solvent can then be replaced with poorly water-soluble organic solvents, such as isododecane. This enabled active loading of α-tocopherol as a lipophilic cargo into the capsule. Overall, surface acetylation of chitosan-coated liposomes produces chitin-deposited nanocapsules with enhanced solvent resistance, offering a promising platform for pharmaceutical, cosmetic, and nanocomposite applications.

  • Access to Document (DOI)

• Preparation of hydrogel and xerogel nanoparticles composed of methylcellulose: possible use in drug delivery and polymer composites

  Fukui Y., Wada K., Fujimoto K.

  Polymer Journal (Springer Nature )  58   287 - 299 2025.12

  Research paper (scientific journal), Joint Work, Last author, Accepted,  ISSN  00323896

  　View Summary

  To improve the water resistance of products prepared from water-soluble cellulose derivatives, we prepared cellulose-based nanoparticles without chemical modifications such as crosslinking. We employed a W/O (water-in-oil) miniemulsion as a nanoreactor to prepare cellulose-based particles. Methylcellulose (MC) was selected as the cellulose-derived biomass polymer. Aqueous nanodroplets, including MC, were suspended in corn oil by homogenization and ultrasonication. MC hydrogel nanoparticles (MC-H) were subsequently obtained via the gelation of MC within the nanodroplets with increasing temperature. Next, to obtain MC xerogel nanoparticles (MC-X), we carried out water evaporation from MC-H. Furthermore, MC-X with different inner structures could be obtained by tuning the temperature and pressure of the evaporation conditions. MC-H and MC-X showed high water resistance because of the strong association of MC chains, which was promoted in confined vessels such as nanodroplets and nanoparticles. In addition, the release of water-soluble substances from MC-H was promoted at 4 °C below the dissolution temperature of MC, whereas MC-X exhibited suppressed release because of the strong association of MC chains. To explore the utility of MC-X as a biomass-derived filler, it was embedded in the polymer film. MC-X was slightly aggregated but evenly distributed within the film without compromising its transparency.

  • Access to Document (DOI)

• Core-shell Particle Embedding into Human Hair: A Novel Approach for Surface Modification and Long-Lasting Hair Coloration

  Fujimoto K., Nishimura M., Fukui Y.

  ACS Omega (ACS)  10 ( 20 ) 20585 - 20592 2025.05

  Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted,  ISSN  2470-1343

  　View Summary

  To embed particles into human hair, core-shell (CS) particles were prepared by seeded emulsion polymerization and were arrayed to the surface of natural hair via dip coating. The particle-coated natural hair was treated at various temperatures in a controlled environment with a relative humidity of 5% (5% RH). No particle embedding was observed at 25 °C. However, the degree of particle embedding (DE) slightly increased at 50 °C and substantially at 150 °C. At 100% RH, embedding was effectively achieved at 50 °C, probably because the adsorbed water acted as a plasticizer, softening the hair. Bleached hair exhibited a significant reduction in surface wettability, whereas the DE of CS particles remained comparable to that of natural hair, indicating that surface wettability does not affect the particle embedding process. On the other hand, hair treated with a reducing agent displayed a notable increase in the DE, reaching approximately 20% even at 25 °C and increasing to 35% at 150 °C. At 100% RH, DE values dramatically increased to approximately 35%, even at 25 °C. Sudan Black B was incorporated into the CS particles to produce stained particles (CS(B) particles). This staining process enabled the coloration of bleached hair by arranging and embedding CS(B) particles. Visual observation confirmed uniform coloration of the hair samples. The color difference (ΔE*) results strongly indicated that bleached hair could be effectively dyed with CS(B) particles. Additionally, the color of CS(B) particle-embedded hair remained stable after ultrasonication, demonstrating that particle embedding ensures long-lasting hair coloration by securely embedding the stained particles within the hair samples.

  • Access to Document (DOI)

• Preparation of a CNF porous membrane and in situ synthesis of silver nanoparticles (AgNPs)

  Fukui Y., Baba E., Fujimoto K.

  RSC Advances (RSC)  15 ( 2 ) 1115 - 1124 2025.01

  Research paper (scientific journal), Joint Work, Last author, Accepted

  　View Summary

  We prepared a cellulose nanofiber (CNF)-based porous membrane with three dimensional cellular structures. CNF was concentrated via a surfactant-induced assembly by mixing CNF with a cationic surfactant, domiphen bromide (DB). Furthermore, they were accumulated by centrifugation to obtain a CNF-DB sol. Next, when the CNF-DB sol was naturally dried, a membrane composed of densely packed CNF was obtained. On the other hand, when the CNF-DB sol was freeze-dried, a porous membrane with the anisotropic cellular structure could be obtained. The interspace between layered CNF sheets was tunable by the DB concentration in the assembly process and the centrifugal force in the accumulation process. FT-IR analysis of the porous membrane showed the formation of hydrogen bonds between the CNF, resulting in facilitation of crosslinking of the CNF and formation of the cellular structures. The obtained CNF-DB membrane exhibited high water resistance. They showed a high ability to absorb hydrophobic dyes such as Nile red and rhodamine B (RhB) due to the presence of the hydrophobic core of DB micelles. Then, the release of RhB could be controlled by the ionic strength in the medium. In addition, they possessed a high ability to adsorb cationic metals such as Ag ions due to the presence of carboxyl moieties of CNF. Next, in situ synthesis of silver nanoparticles (AgNPs) was carried out by employing the CNF-DB membrane as a template for Ag ion adsorption and reduction. Deposition of AgNPs could be observed on the CNF-DB membrane, which suppressed aggregation of AgNPs. Almost all AgNPs were arrayed apart from each other to generate the hotspots, which could enhance surface-enhanced Raman scattering (SERS) of AgNPs. Such an AgNPs-CNF composite membrane could be applied for a label-free analysis of adsorbed RhB.

  • Access to Document (DOI)

• Preparation of a robust and degradable nanocapsule by polymer deposition over the liposome for loading and release of cargos

  Fukui Y., Ito J., Takeiri M., Fujimoto K.

  Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier)  676   132160 2023.11

  Research paper (scientific journal), Joint Work, Last author, Accepted,  ISSN  09277757

  　View Summary

  We prepared biobased nanocapsules by the polymer deposition over the ceramide-containing liposomes to render abilities to load versatile substances and to release them in response to enzymatic degradation of the capsule wall. First, we carried out phosphorylation of chitosan (CHI) to make it amphoteric. Then, we prepared a liposome containing glucosylceramide (GlcCer) and carried out deposition of phosphorylated chitosan (PCHI). The obtained capsule showed high structural stability against solubilization by surfactants and organic solvents, where it maintained its size even in 90 vol% DMSO. Next, we attempted to load various substances into the capsule. A lipophilic Nile red dissolved in 50 vol% DMSO could be loaded into the capsule without rupturing. The loading capacity of PCHI-deposited liposomes was almost three times higher than that of bare liposomes. Its release was suppressed to less than 10 % in an aqueous solution, whereas it could be released to more than 40 % when a small amount of surfactant was added to mimic a lipophilic environment. Also, an amphoteric nature of the capsule derived from PCHI allowed for loading of both cationic and anionic substances. Furthermore, lysozyme (Lyso) was deposited onto the capsule to provide the capsule wall with the enzymatic degradability. Although the release of substances from the capsule was suppressed to less than 10 % without Lyso, it was increased to approximately 50 % by enzymatic degradation of the PCHI layer.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Development of next-generation technologies by supra-structured materials built from functional particles

  Fujimoto, Keiji

  福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会)  2020

• Development of next generation nano-biomaterials by cell surface engineering

  Fujimoto, Keiji

  科学研究費補助金研究成果報告書 2010

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Development of Multi-Functional Nanocapsules by Surface and Inner Modifications of Liposomes with Polymers

  藤本啓二、福井有香

  月刊ファインケミカル ((株)シーエムシー出版)  54 ( 2 ) 5 - 11 2025.05

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Corresponding author

• Fabrication of Polymer Particle Adhesives for Multi-material Joining

  FUJIMOTO Keiji

  Hosokawa Powder Technology Foundation ANNUAL REPORT (Hosokawa Powder Technology Foundation)  28   82 - 87 2021.05

  Internal/External technical report, pre-print, etc., Single Work

  　View Summary

  <p>There are plenty of adhesive supra-structures in nature. For instance, geckos have a number of submicron-sized fibers on their feet, which allow it to stick and adhere strongly along the contour of the surface. This structure makes it possible for geckos to show strong adhesiveness to various surfaces. Inspired by such adhesion mechanism derived from micro- and nano-structures, I aimed to create a multi-layered gel membrane possessing surface adhesiveness and followability. The layer-by-layer deposition of gel particles via a polymer complex was carried out onto the gel base to create 3D gel structures. By tuning the type and the number of the layer-by-layer deposition, I could modulate elasticity and surface followability of the gel membrane to improve its adhesiveness.</p>

  • Access to Document (DOI)

• 高分子微粒子の作り方と活かし方

  藤本啓二, 福井有香

  粉体技術 13   27 - 34 2021

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

• 高分子微粒子のつくり方と活かし方

  藤本啓二、福井有香

  塗装工学 54   394 - 403 2019

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

• 高分子微粒子の創りかたと医用高分子への活かしかた

  藤本啓二, 福井有香

  工業材料 65   36 - 42 2017

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• リポソーム表面へのポリマー層の構築による油中分散型ナノカプセルの作製と難水溶性物質の封入

  三原友美、福井有香、藤本啓二

  [Domestic presentation]  第55回医用高分子シンポジウム (産総研、お台場) , 

  2026.07

  , 

  Poster presentation, 高分子学会

• ミニエマルションを用いたキトサングリーン微粒子の作製と抗酸化剤の保持・放出

  福井有香、澤田さくら、藤本啓二、茂垣里奈、五十島健史

  [Domestic presentation]  (産総研、お台場) , 

  2026.07

  , 

  Oral presentation (general), 高分子学会

• アルギン酸とアガロースのゲル化を用いたリポナノカプセル含有ゲルの作製

  廣田彩、福井有香、藤本啓二

  [Domestic presentation]  第55回医用高分子シンポジウム (産総研、お台場) , 

  2026.07

  , 

  Poster presentation, 高分子学会

• 可能性志向研究による微粒子材料の創製と機能化

  藤本啓二

  第158回学術大会, 

  2026.05

  , 

  Oral presentation (invited, special), 毛髪科学技術者協会

• タンニン酸とゼラチンを用いた粘着性コロイド構造体の構築

  髙橋礼、小松賢治、福井有香、藤本啓二

  [Domestic presentation]  第34回ポリマー材料フォーラム (ウインク愛知) , 

  2025.12

  , 

  Poster presentation, 高分子学会

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Works 【 Display / hide 】

Works 【 Display / hide 】

• 有機化学演習（高分子化学）

  FUJIMOTO KEIJI

  1991.04

  -

  Present

  , 

  Other, Joint

• 応用化学実験第２

  FUJIMOTO KEIJI

  1991.04

  -

  Present

  , 

  Other, Joint

• 自然科学実験（化学）

  FUJIMOTO KEIJI

  1991.04

  -

  Present

  , 

  Other, Joint

• 応用高分子化学

  FUJIMOTO KEIJI

  1996.04

  -

  1999.03

  , 

  Other, Single

• 天然高分子

  FUJIMOTO KEIJI

  1999.04

  -

  2000.03

  , 

  Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• 天然高分子の複合粒子３

  Date applied： 特願2024-196136  2024 

  Patent, Joint

• 天然高分子の複合粒子１

  Date applied： 特願2024-114767  2024 

  Date issued： 特願2024-114767 

  Patent, Joint

• 天然高分子の複合粒子２

  Date applied： 特願2024-196135  2024 

  Patent, Joint

• リポソームを鋳型とする中空ナノ粒子の作製方法

  Date applied： 特願2004-113635  2004.04 

  Patent, Joint

• 脂質二重膜とナノサイズ蛍光体複合体

  Date applied： 特願2003-410841  2003.12 

  Patent, Joint

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• BEST POSTER PRIZE in 2010 MRS Fall Meeting

  FUJIMOTO KEIJI, 2010.12, MRS, Development of a particle nano-imprinting technique by core-shell particles

  Type of Award： International academic award (Japan or overseas)

• スマートポリマー国際シンポジウム・ベストポスター賞

  藤本 啓二, 1998.06, スマートポリマー国際シンポジウム

• 高分子学会研究奨励賞

  藤本 啓二, 1997.05, 高分子学会

• 日本MRS学会研究奨励賞

  藤本 啓二, 1993.12, 日本MRS学会

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• FUNDAMENTAL POLYMER CHEMISTRY

  2026

• GRADUATE RESEARCH ON FUNDAMENTAL SCIENCE AND TECHNOLOGY 1

  2026

• DESIGN AND SYNTHESIS OF POLYMERIC BIOMATERIALS

  2026

• DOCTORAL RESEARCH ON CHEMISTRY, LIFE SCIENCE, AND INFORMATICS

  2026

• GRADUATE RESEARCH ON CHEMISTRY, LIFE SCIENCE, AND INFORMATICS 1

  2026

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 高分子化学基礎

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture, Within own ｆaculty, 200people

• バイオマテリアル特論

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Within own ｆaculty, 40people

• 高分子化学

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Within own ｆaculty, 135people

• 応用高分子化学

  慶應義塾大学

  2017.04

  -

  2018.03

• 天然高分子

  Keio Univiersity

  1999.04

  -

  2000.03

  , 

  Spring Semester, Lecture, Within own ｆaculty

Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• 可能性志向研究による微粒子材料の創製と機能化

  毛髪科学技術者協会, 第158回学術大会 (ハイアットリージェンシー東京)

  , 

  2026.05

• バイオナノ粒子からミニエマルションを用いたグリーン微粒子と多孔質体の作製へ

  近畿化学協会重合工学部会, 近畿化学協会重合工学部会 令和 5 年度 重合工学レクチャーシリーズ No.10 (大阪科学技術センター)

  , 

  2024.01

• 先端応用化学特別講義Ⅲ

  東京農工大

  2023.11

Media Coverage 【 Display / hide 】

Media Coverage 【 Display / hide 】

• 慶大　表面が硬い層のナノ粒子開発　歯・骨の欠損治療に応用へ

  日経産業新聞, 2018.01

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 高分子学会, 

  2011.04

  -

  Present

• 日本バイオマテリアル学会, 

  2002

  -

  Present

• American Chemcal Society, 

  1998.04

  -

  Present

• 繊維学会, 

  1991

  -

  Present

• 日本DDS学会

  　

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2023.04

  -

  Present

  医用高分子研究会アドバイザー, 高分子学会

• 2012.04

  -

  2014.03

  高分子学会　医用高分子研究会　委員長, 高分子学会

• 2011.04

  -

  2017.03

  代表会員, 高分子学会

• 2004.06

  -

  2008.05

  高分子学会湘北懇話会世話人, 高分子学会

• 2004.06

  -

  2008.05

  高分子学会関東支部理事, 高分子学会

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