福井 有香 (フクイ ユウカ)

Fukui, Yuuka

写真a

所属(所属キャンパス)

理工学部 応用化学科 (矢上)

職名

専任講師

HP

経歴 【 表示 / 非表示

  • 2015年04月
    -
    2017年03月

    慶應義塾大学, 理工学部 応用化学科, 助教

  • 2017年04月
    -
    継続中

    慶應義塾大学, 理工学部 応用化学科, 専任講師

学歴 【 表示 / 非表示

  • 2003年04月
    -
    2007年03月

    慶應義塾大学, 理工学部, 応用化学科

    大学, 卒業

  • 2007年04月
    -
    2009年03月

    慶應義塾大学大学院, 理工学研究科, 生物化学専修

    大学院, 博士前期

  • 2009年04月
    -
    2012年03月

    慶應義塾大学大学院, 理工学研究科, 生物化学専修

    大学院, 博士後期

学位 【 表示 / 非表示

  • 博士(工学), 慶應義塾大学, 課程, 2012年03月

 

著書 【 表示 / 非表示

  • 高分子微粒子の最新技術動向

    シーエムシー出版, 2022年07月

    担当範囲: 高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

  • 高分子基礎ガイド

    藤本啓二, 川口正剛, 小泉智, 福井有香, 箕田雅彦, 本柳仁, 朝倉書店, 2022年02月,  ページ数: 153

  • 高分子微粒子のつくり方と活かし方

    藤本啓二, 福井有香, 塗装工学 (一般社団法人 日本塗装技術協会) 54 ( 11 ) , 2019年11月,  ページ数: 394 - 403

  • ドラッグデリバリーシステム・バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発

    福井有香, 藤本啓二, シーエムシー出版, 2018年08月

    担当範囲: リポソームの表面改質によるナノカプセルの作製と機能化,  担当ページ: 195-206

  • 中空微粒子の合成と応用

    福井 有香藤本 啓二, シーエムシー出版, 2017年

    担当範囲: リポソームを鋳型とした中空微粒子の合成

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論文 【 表示 / 非表示

  • Functionalization of keratin nanoparticles by their internal modifications

    Fukui Y., Ito K., Fujimoto K.

    Polymer Journal (Polymer Journal)  2022年06月

    研究論文(学術雑誌), 共著, 責任著者, 査読有り,  ISSN  00323896

     概要を見る

    We prepared keratin nanoparticles, which could respond to temperature and pH changes and to redox reactions, by electrostatic association of keratin and a cationic surfactant, dioctadecyl dimethyl ammonium chloride (DODAC). Solubilized keratin chains were assembled into nanoparticles (Ker-DODAC) and then crosslinked by disulfide formation. The resultant nanoparticles (Ker-DODACss) possessed a hydrophobic core composed of DODAC, enabling hydrophobic compounds to be loaed and retained in the core. By increasing the temperature, the fluidity of the core was increased, resulting in Ker-DODACss swelling and burst release of loaded compounds. Next, cholesterol was loaded into Ker-DODACss to modify the inner environment, such as the hydrophobicity and fluidity of the core. The nanoparticles (Ker-DODACss-Chol) exhibited reduced fluidity of the core and suppressed release of the payload. Furthermore, the release could be triggered by decreasing the electrostatic interaction between keratin and DODAC at pH values lower than 7.4. It was also found that Ker-DODACss-Chol possessed the ability to release payloads by breaking disulfide bonds. As a further internal modification, we incorporated a lipophilic antioxidant, α-tocopherol, into Ker-DODACss-Chol. It was confirmed that Ker-DODACss-Chol could act as a physical barrier to prevent α-tocopherol from undergoing oxidative degradation.

  • Preparation of a deformable nanocapsule by living radical polymerization in a liposome

    Fukui Y., Fukui A., Fujimoto K.

    Polymer Journal (Polymer Journal)  54 ( 7 ) 893 - 901 2022年

    ISSN  00323896

     概要を見る

    We aimed to prepare an elastic nanocapsule by internal modification of a liposome with living radical polymerization. First, monomers and photoiniferters were encapsulated in liposomes. Then, UV light irradiation was used to conduct living radical polymerization in the liposomes. The obtained nanocapsules showed good absorption and retention of chemical substances depending on the binding ability to the incorporated polymers, and the absorption capacity could be controlled by the length and dissolved state of the polymer chains. In addition, dynamic morphological changes in the capsules were observed when liposomes with high membrane fluidity were employed. Morphological changes in the nanocapsules were induced by altering the pH value and ionic strength, resulting in the release of cargo in response to these environmental conditions.

  • Preparation of agarose xerogel nanoparticles by solvent evaporation from water nanodroplets

    Fukui Y., Inamura R., Fujimoto K.

    Polymer Journal (Polymer Journal)  53 ( 7 ) 815 - 821 2021年07月

    ISSN  00323896

     概要を見る

    We developed a W/O miniemulsion reactor system enabling the preparation of biopolymer nanoparticles and control of their morphologies and inner microstructures. First, the W/O miniemulsion was prepared by suspending water nanodroplets containing agarose in oil. Then, we produced agarose hydrogel nanoparticles (AgarH) by the gelation of agarose in nanodroplets. Next, we prepared agarose xerogel nanoparticles (AgarX) by precisely tuning the water evaporation from AgarH. We controlled the morphologies (solid and hollow) and crystal structure of AgarX by changing the pressure and temperature during water evaporation. In fact, AgarX with a hollow structure was generated through rapid evaporation at a low pressure. AgarH was dissolved in Milli-Q water when the temperature was raised to 90 °C. On the other hand, AgarX remained a solid particle under the same conditions, likely because of its high crystallinity. We expect that this technique can be applied to prepare xerogels of diverse biomass-based polymers for the replacement of synthetic polymers.

  • Creation of porous polymeric membranes by accumulation of water nanodroplets in a miniemulsion system

    Fukui Y., Fujino R., Sugaya Y., Fujimoto K.

    Polymer Journal (Polymer Journal)  52 ( 9 ) 1077 - 1083 2020年09月

    ISSN  00323896

     概要を見る

    © 2020, The Society of Polymer Science, Japan. We developed a miniemulsion templating method to prepare porous polymeric membranes. First, water nanodroplets were suspended in an oil phase by using a nonionic and polymeric surfactant to form a water-in-oil (W/O) miniemulsion. After the nanodroplets accumulated by centrifugation, a small amount of monomer was added as an oil phase to resuspend the water nanodroplets in a monomer phase. Then, photopolymerization of the monomer phase was conducted to generate pores in the polymeric matrix. The size of the nanodroplets was tuned by the surfactant concentration to control the pore size of the membranes. We could produce pore morphologies such as closed-cellular, open-cellular, and bicontinuous structures by tuning the volume fraction of the nanodroplets. Alternatively, nanodroplets were accumulated by centrifugation, and then further surfactants were added to the monomer to suppress the coalescence of nanodroplets. This enabled us to generate a highly porous open-cellular structure while maintaining the size and spherical shape. Next, HAuCl4 was reduced by using the surfactant displayed at the inner surface of the pore wall as the reducing agent. Gold nanoparticles were produced in the inner pores of the polymeric membrane, showing coloration derived from local surface plasmon resonance.

  • Tuning of particle indentation by surface modification of polymer particles and substrates

    Fukui Y., Yamamoto K., Yamamoto T., Fujimoto K.

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids and Surfaces A: Physicochemical and Engineering Aspects)  588 2020年03月

    ISSN  09277757

     概要を見る

    © 2019 Elsevier B.V. We studied the influence of the chemical properties of the polymer particle and the polymer substrate on particle indentation. The polymer particles were arrayed over the polymer substrate and heat treatment (annealing) was conducted above the glass transition temperature (Tg) of bulk polymer to indent polymer particles into the polymer substrate. Surface topologies of particle-indented surfaces were observed with a field-emission scanning electron microscope (FE-SEM) and the degree of particle indentation (DI) was evaluated with a scanning probe microscope (SPM). The particle-arrayed substrate was placed upside down and then heat treatment was carried out. It was found that there was no effect of gravity on particle indentation. To prepare polymer particles with different chemical properties, surface grafting of hydrophobic, hydrophilic, cationic and anionic polymer chains was carried out by iniferter-initiated living radical polymerization. We found that the indentation of these particles was influenced by the outermost surface of the particle. Next, to investigate the effect of the substrate surface on particle indentation, sulfonation of the polystyrene (PS) substrate was carried out with concentrated sulfuric acid. We found that the surface property of the substrate also influenced particle indentation. From these results, we concluded that particle indentation would be determined by the interaction between the particle surface and the substrate surface. Finally, we intended to analyze the viscoelastic property of the substrate surface by particle indentation. We could estimate Tg values of PS and polyvinyl chloride (PVC) substrates by observing the particle indentation at the different annealing temperatures.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

総説・解説等 【 表示 / 非表示

  • ミネラル層で覆われたリポナノカプセルの創製

    福井有香

    PHARM STAGE (技術情報協会 )  18 ( 5 )  2018年08月

    記事・総説・解説・論説等(学術雑誌), 単著

  • 機能性高分子微粒子の合成と作製技術

    福井有香, 藤本啓二

    MATERIAL STAGE (技術情報協会 )  18 ( 2 ) 1 - 6 2018年

    記事・総説・解説・論説等(学術雑誌), 共著

研究発表 【 表示 / 非表示

  • Preparation of agarose xerogel nanoparticles by solvent evaporation from water nanodroplets

    福井有香, 稲村隆太郎, 藤本啓二

    第71回高分子学会年次大会, 

    2022年05月

    口頭発表(招待・特別)

  • Controlled functionalization of biopolymer-deposited liposomes by the enzymatic degradation

    Yuuka Fukui, Hikari Otsuka, Keiji Fujimoto

    Pacifichem 2021, 

    2021年12月

    口頭発表(一般)

  • リポソーム内部へのDNA封入とミネラル化による機能創出

    浅野いぶき, 福井有香, 藤本啓二

    第43回日本バイオマテリアル学会大会, 

    2021年11月

    ポスター発表

  • 多糖と酵素を積層化したセラミド含有リポナノカプセルの創製

    伊藤純名, 福井有香, 藤本啓二

    第43回日本バイオマテリアル学会大会, 

    2021年11月

    ポスター発表

  • ミニエマルションによる酵素被覆ナノ粒子の作製とH2O2生成の制御

    瀬戸隆継, 福井有香, 藤本啓二

    第43回日本バイオマテリアル学会大会, 

    2021年11月

    ポスター発表

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競争的研究費の研究課題 【 表示 / 非表示

  • 骨疾患治療のための骨環境応答性ナノツールの開発

    2019年04月
    -
    2021年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 福井 有香, 若手研究, 補助金,  研究代表者

受賞 【 表示 / 非表示

  • 2021年度Polymer Journal論文賞-日本ゼオン賞

    2022年05月, 公益社団法人 高分子学会

    受賞区分: 国内学会・会議・シンポジウム等の賞

     説明を見る

    論文「ナノサイズの水滴を反応場としたバイオマス高分子微粒子作製技術の開発」が評価されたことによる

  • The Young Investigator Award Gold Prize(11th Liposome Research Days Conference)

    福井 有香, 2008年07月, Preparation of Lipo-nanocapsules by the layer-by-layer deposition of polysaccharides and coating of calcium phosphate onto a liposome

    受賞区分: 国内学会・会議・シンポジウム等の賞

 

担当授業科目 【 表示 / 非表示

  • 応用化学輪講

    2022年度

  • 理工学基礎実験

    2022年度

  • 応用化学実験D

    2022年度

  • 現代化学概論

    2022年度

  • 卒業研究

    2022年度

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所属学協会 【 表示 / 非表示

  • Materials Research Society, 

    2011年11月
    -
    継続中
  • アメリカ化学会, 

    2009年05月
    -
    継続中
  • 日本バイオマテリアル学会, 

    2007年11月
    -
    継続中
  • 高分子学会, 

    2007年05月
    -
    継続中