KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2015.04

  -

  2017.03

  慶應義塾大学, 理工学部　応用化学科, 助教

• 2017.04

  -

  2023.03

  慶應義塾大学, 理工学部　応用化学科, 専任講師

• 2023.04

  -

  Present

  Keio University, 理工学部　応用化学科, Associate Professor

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2003.04

  -

  2007.03

  Keio University, 理工学部, 応用化学科

  University, Graduated

• 2007.04

  -

  2009.03

  慶應義塾大学大学院, 理工学研究科, 生物化学専修

  Graduate School, Master's course

• 2009.04

  -

  2012.03

  慶應義塾大学大学院, 理工学研究科, 生物化学専修

  Graduate School, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（工学）, Keio University, Coursework, 2012.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Nanotechnology/Materials / Polymer chemistry (コロイド・界面化学、微粒子材料、DDS、バイオマテリアル、グリーンマテリアル)

Books 【 Display / hide 】

Books 【 Display / hide 】

• 高分子微粒子の最新技術動向

  シーエムシー出版, 2022.07

  Scope: 高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

• 高分子基礎ガイド

  藤本啓二, 川口正剛, 小泉智, 福井有香, 箕田雅彦, 本柳仁, 朝倉書店, 2022.02,  Page： 153

• 高分子微粒子のつくり方と活かし方

  藤本啓二, 福井有香, 塗装工学 (一般社団法人 日本塗装技術協会) 54 ( 11 ) , 2019.11,  Page： 394 - 403

• ドラッグデリバリーシステム・バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発

  福井有香, 藤本啓二, シーエムシー出版, 2018.08

  Scope: リポソームの表面改質によるナノカプセルの作製と機能化,  Contact page： 195-206

• 中空微粒子の合成と応用

  FUKUI YuukaFUJIMOTO Keiji, シーエムシー出版, 2017

  Scope: リポソームを鋳型とした中空微粒子の合成

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Suspension of liposome-based nanocapsules in organic solvents via surface acetylation of chitosan-deposited liposomes

  Tomomi Mihara, Yuuka Fukui, Keiji Fujimoto

  Colloids and Surfaces B: Biointerfaces (Elsevier)  259   115346 2025.12

  Research paper (scientific journal), Joint Work, Corresponding author, Accepted,  ISSN  09277765

  　View Summary

  Liposomes are valuable drug and cosmetic carriers but face limitations in stability and active loading from external phases. Polymer-coated liposomes (liponanocapsules) have improved robustness, and this study advances the approach by acetylating chitosan-coated liposomes to form chitin-deposited capsules, leveraging chitin's biocompatibility and insolubility to enhance the structural and colloidal stability in organic solvents and oils. This represents the first report of suspensions of liposome-based capsules in such media. Anionic liposomes prepared from dilauroyl phosphatidyl acid acquire a hydrodynamic diameter increase from 100 to 190 nm and shift in ζ-potential from negative to positive upon chitosan deposition. Surface acetylation of the deposited chitosan with sodium acetate and a condensing agent yields chitin-deposited liposomes (Lipo[-]-chitin), with the degree of acetylation (DA) controlled by changing the reagent concentration. Lipo[-]-chitin shows a shift in the phase transition of the lipid membrane to a higher temperature owing to the suppression of lipid fluidity, suggesting that the capsules become rigid and robust. The hydrodynamic diameter of Lipo[-]-chitin in water increases with the DA because of capsule aggregation. By contrast, Lipo[-]-chitin becomes smaller in mixtures of water and water-miscible organic solvents, such as dimethyl sulfoxide (DMSO), ethanol, and acetone, indicating a positive impact of acetylation on the colloidal stability. In mixtures of water with DMSO or ethanol, a higher DA reduces the colloidal stability, whereas the opposite trend is observed in acetone. These results indicate that the colloidal stability of the acetylated capsules is strongly governed by the DA. Notably, Lipo[-]-chitin with a higher DA can be suspended in 100 % ethanol without aggregation or rupture. The solvent can then be replaced with poorly water-soluble organic solvents, such as isododecane. This enabled active loading of α-tocopherol as a lipophilic cargo into the capsule. Overall, surface acetylation of chitosan-coated liposomes produces chitin-deposited nanocapsules with enhanced solvent resistance, offering a promising platform for pharmaceutical, cosmetic, and nanocomposite applications.

  • Access to Document (DOI)

• Preparation of Hydrogel and Xerogel Nanoparticles Composed of Methylcellulose: Possible Use in Drug Delivery and Polymer Composites

  Yuuka Fukui, Kaho Wada, Keiji Fujimoto

  Polymer Journal (Springer Nature)  58 ( 3 ) 287 - 299 2025

  Joint Work, Lead author, Corresponding author, Accepted,  ISSN  00323896

  　View Summary

  To improve the water resistance of products prepared from water-soluble cellulose derivatives, we prepared cellulose-based nanoparticles without chemical modifications such as crosslinking. We employed a W/O (water-in-oil) miniemulsion as a nanoreactor to prepare cellulose-based particles. Methylcellulose (MC) was selected as the cellulose-derived biomass polymer. Aqueous nanodroplets, including MC, were suspended in corn oil by homogenization and ultrasonication. MC hydrogel nanoparticles (MC-H) were subsequently obtained via the gelation of MC within the nanodroplets with increasing temperature. Next, to obtain MC xerogel nanoparticles (MC-X), we carried out water evaporation from MC-H. Furthermore, MC-X with different inner structures could be obtained by tuning the temperature and pressure of the evaporation conditions. MC-H and MC-X showed high water resistance because of the strong association of MC chains, which was promoted in confined vessels such as nanodroplets and nanoparticles. In addition, the release of water-soluble substances from MC-H was promoted at 4 °C below the dissolution temperature of MC, whereas MC-X exhibited suppressed release because of the strong association of MC chains. To explore the utility of MC-X as a biomass-derived filler, it was embedded in the polymer film. MC-X was slightly aggregated but evenly distributed within the film without compromising its transparency.

  • Access to Document (DOI)

• Core-shell Particle Embedding into Human Hair: A Novel Approach for Surface Modification and Long-Lasting Hair Coloration

  Fujimoto K., Nishimura M., Fukui Y.

  ACS Omega 10 ( 20 ) 20585 - 20592 2025.05

  　View Summary

  To embed particles into human hair, core-shell (CS) particles were prepared by seeded emulsion polymerization and were arrayed to the surface of natural hair via dip coating. The particle-coated natural hair was treated at various temperatures in a controlled environment with a relative humidity of 5% (5% RH). No particle embedding was observed at 25 °C. However, the degree of particle embedding (DE) slightly increased at 50 °C and substantially at 150 °C. At 100% RH, embedding was effectively achieved at 50 °C, probably because the adsorbed water acted as a plasticizer, softening the hair. Bleached hair exhibited a significant reduction in surface wettability, whereas the DE of CS particles remained comparable to that of natural hair, indicating that surface wettability does not affect the particle embedding process. On the other hand, hair treated with a reducing agent displayed a notable increase in the DE, reaching approximately 20% even at 25 °C and increasing to 35% at 150 °C. At 100% RH, DE values dramatically increased to approximately 35%, even at 25 °C. Sudan Black B was incorporated into the CS particles to produce stained particles (CS(B) particles). This staining process enabled the coloration of bleached hair by arranging and embedding CS(B) particles. Visual observation confirmed uniform coloration of the hair samples. The color difference (ΔE*) results strongly indicated that bleached hair could be effectively dyed with CS(B) particles. Additionally, the color of CS(B) particle-embedded hair remained stable after ultrasonication, demonstrating that particle embedding ensures long-lasting hair coloration by securely embedding the stained particles within the hair samples.

  • Access to Document (DOI)

• Preparation of a CNF porous membrane and in situ synthesis of silver nanoparticles (AgNPs)

  Yuuka Fukui, Eriko Baba, Keiji Fujimoto

  RSC Advances (Royal Society of Chemistry)  15 ( 2 ) 1115 - 1124 2025.01

  Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted

  　View Summary

  We prepared a cellulose nanofiber (CNF)-based porous membrane with three dimensional cellular structures. CNF was concentrated via a surfactant-induced assembly by mixing CNF with a cationic surfactant, domiphen bromide (DB). Furthermore, they were accumulated by centrifugation to obtain a CNF-DB sol. Next, when the CNF-DB sol was naturally dried, a membrane composed of densely packed CNF was obtained. On the other hand, when the CNF-DB sol was freeze-dried, a porous membrane with the anisotropic cellular structure could be obtained. The interspace between layered CNF sheets was tunable by the DB concentration in the assembly process and the centrifugal force in the accumulation process. FT-IR analysis of the porous membrane showed the formation of hydrogen bonds between the CNF, resulting in facilitation of crosslinking of the CNF and formation of the cellular structures. The obtained CNF-DB membrane exhibited high water resistance. They showed a high ability to absorb hydrophobic dyes such as Nile red and rhodamine B (RhB) due to the presence of the hydrophobic core of DB micelles. Then, the release of RhB could be controlled by the ionic strength in the medium. In addition, they possessed a high ability to adsorb cationic metals such as Ag ions due to the presence of carboxyl moieties of CNF. Next, in situ synthesis of silver nanoparticles (AgNPs) was carried out by employing the CNF-DB membrane as a template for Ag ion adsorption and reduction. Deposition of AgNPs could be observed on the CNF-DB membrane, which suppressed aggregation of AgNPs. Almost all AgNPs were arrayed apart from each other to generate the hotspots, which could enhance surface-enhanced Raman scattering (SERS) of AgNPs. Such an AgNPs-CNF composite membrane could be applied for a label-free analysis of adsorbed RhB.

  • Access to Document (DOI)

• Preparation of a robust and degradable nanocapsule by polymer deposition over the liposome for loading and release of cargos

  Fukui Y., Ito J., Takeiri M., Fujimoto K.

  Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids and Surfaces A: Physicochemical and Engineering Aspects)  676 2023.11

  ISSN  09277757

  　View Summary

  We prepared biobased nanocapsules by the polymer deposition over the ceramide-containing liposomes to render abilities to load versatile substances and to release them in response to enzymatic degradation of the capsule wall. First, we carried out phosphorylation of chitosan (CHI) to make it amphoteric. Then, we prepared a liposome containing glucosylceramide (GlcCer) and carried out deposition of phosphorylated chitosan (PCHI). The obtained capsule showed high structural stability against solubilization by surfactants and organic solvents, where it maintained its size even in 90 vol% DMSO. Next, we attempted to load various substances into the capsule. A lipophilic Nile red dissolved in 50 vol% DMSO could be loaded into the capsule without rupturing. The loading capacity of PCHI-deposited liposomes was almost three times higher than that of bare liposomes. Its release was suppressed to less than 10 % in an aqueous solution, whereas it could be released to more than 40 % when a small amount of surfactant was added to mimic a lipophilic environment. Also, an amphoteric nature of the capsule derived from PCHI allowed for loading of both cationic and anionic substances. Furthermore, lysozyme (Lyso) was deposited onto the capsule to provide the capsule wall with the enzymatic degradability. Although the release of substances from the capsule was suppressed to less than 10 % without Lyso, it was increased to approximately 50 % by enzymatic degradation of the PCHI layer.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Preparation of liposome-based nanocapsules to aim for transdermal delivery of various drugs/actives

  Hukui, Yuka

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2023

• Development of bone-responsive drug delivery system for the therapy of osteoporosis

  Fukui, Yūka

  科学研究費補助金研究成果報告書 2020

• Preparation of porous structures by miniemulsion templating method and their applications for separation membranes

  Fukui, Yuuka

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2018

• Development of liposome-based biomaterials for bone therapeutics

  Fukui, Yuka

  科学研究費補助金研究成果報告書 2013

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• ポリマーとの複合化によるリポソームの機能創出の試み

  藤本啓二、福井有香

  月刊ファインケミカル ((株)シーエムシー出版)   2025.05

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author

• ミネラル層で覆われたリポナノカプセルの創製

  福井有香

  PHARM STAGE (技術情報協会 )  18 ( 5 )  2018.08

  Article, review, commentary, editorial, etc. (scientific journal), Single Work

• 機能性高分子微粒子の合成と作製技術

  福井有香, 藤本啓二

  MATERIAL STAGE (技術情報協会 )  18 ( 2 ) 1 - 6 2018

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• タンニン酸とゼラチンを用いた粘着性コロイド構造体の構築

  髙橋礼・小松賢治・福井有香・藤本啓二

  [Domestic presentation]  第34回ポリマー材料フォーラム, 

  2025.12

  , 

  Poster presentation

• ミニエマルションを用いたキトサングリーン微粒子の作製と抗酸化剤の保持・放出

  澤田さくら,福井有香,藤本啓二,五十島健史,茂垣里奈

  [Domestic presentation]  第34回ポリマー材料フォーラム, 

  2025.12

  , 

  Poster presentation

• リビングラジカル重合によるポリマー複合化ケラチン粒子の作製

  竹石真歩子,福井有香,藤本啓二

  [Domestic presentation]  第34回ポリマー材料フォーラム, 

  2025.12

  , 

  Poster presentation

• O/W型ミニエマルションをテンプレートとしたCO2応答性ポーラスゲルの作製

  峰島昌生,鈴木泰平,住田晴菜,福井有香,藤本啓二

  [Domestic presentation]  第34回ポリマー材料フォーラム, 

  2025.12

  , 

  Poster presentation

• 微粒子の付着・埋没による毛髪の表面分析と改質

  松原美咲,西村惠,福井有香,藤本啓二,五十島健史,竹田彩乃

  [Domestic presentation]  第34回ポリマー材料フォーラム, 

  2025.12

  , 

  Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 経皮薬物送達システムを指向したリポソーム型ナノカプセルの開発

  2024.04

  -

  2027.03

  基盤研究(C), Principal investigator

• ナノサイズの水滴を反応場としたグリーン微粒子作製技術の開発

  2023.04

  -

  2024.03

  公益財団法人豊田理化学研究所, 2023 年度 豊田理研スカラー, Research grant, Principal investigator

• 多様な物質の経皮薬物送達を可能とするリポソーム型ナノカプセルの創製

  2023.04

  -

  2024.03

  塾内助成（学術研究支援部）, 2023 年度 学事振興資金（個人研究特 A）, Research grant, Principal investigator

• ナノ液滴をテンプレートとした高分子多孔質膜の創製研究

  2023

  -

  Present

  株式会社リバネス, 第 58 回リバネス研究費 東洋紡 高分子科学賞, Research grant, Principal investigator

• リポソームをベースとした経皮薬剤送達キャリアの開発

  2020.04

  -

  2021.03

  公益財団法人 池谷科学技術振興財団, 2020 年度 研究助成, Research grant, Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• 天然高分子の複合粒子２

  Date applied： 特願2024-196136   2024 

  Patent, Joint

• 天然高分子の複合粒子３

  Date applied： 特願2024-196135   2024 

  Patent, Joint

• 天然高分子の複合粒子１

  Date applied： 特願2024-114767   2024 

  Patent, Joint

• 天然高分子の複合粒子２

  Date applied： 特願2024-196136    

  Patent, Joint

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 2023年度日本バイオマテリアル学会科学奨励賞

  福井　有香, 2023.07, 一般財団法人日本バイオマテリアル学会, リポソームをテンプレートとした多機能ナノカプセルの開発

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 第58回リバネス研究費　東洋紡高分子科学賞

  2023.03

  Type of Award： Award from publisher, newspaper, foundation, etc.

• 2021年度Polymer Journal論文賞-日本ゼオン賞

  2022.05, 公益社団法人 高分子学会

  Type of Award： Award from Japanese society, conference, symposium, etc.

  　View Description

  論文「ナノサイズの水滴を反応場としたバイオマス高分子微粒子作製技術の開発」が評価されたことによる

• The Young Investigator Award Gold Prize(11th Liposome Research Days Conference)

  FUKUI Yuuka, 2008.07, Preparation of Lipo-nanocapsules by the layer-by-layer deposition of polysaccharides and coating of calcium phosphate onto a liposome

  Type of Award： Award from international society, conference, symposium, etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• MOLECULAR CHEMISTRY AND CHEMICAL BIOLOGY PRACTICAL RESEARCH A

  2026

• BACHELOR'S THESIS

  2026

• INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

  2026

• SEMINAR IN MOLECULAR CHEMISTRY AND CHEMICAL BIOLOGY 2

  2026

• GRADUATE RESEARCH ON CHEMISTRY, LIFE SCIENCE, AND INFORMATICS 1

  2026

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Media Coverage 【 Display / hide 】

Media Coverage 【 Display / hide 】

• はじめは丈夫でゆっくりと壊れていくナノカプセル〜多様な物質の封入と分解放出

  公益社団法人　高分子学会, 2023.05

• 慶大　表面が硬い層のナノ粒子開発　歯・骨の欠損治療に応用へ

  日経産業新聞, 2018.01

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本化学会, 

  2023

  -

  Present

• 医用高分子研究会, 

  2023

  -

  Present

• American Chemical Society, 

  2009.05

  -

  Present

• 日本バイオマテリアル学会, 

  2007.11

  -

  Present

• 高分子学会, 

  2007.05

  -

  Present

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2026.04

  -

  Present

  運営委員, 医用高分子研究会

• 2023

  -

  Present

  評議委員, 日本バイオマテリアル学会