Fukui, Yuuka

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry （Yagami）

Position

Assistant Professor/Senior Assistant Professor

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Career 【 Display / hide 】

  • 2015.04
    -
    2017.03

    慶應義塾大学, 理工学部　応用化学科, 助教

  • 2017.04
    -
    Present

    慶應義塾大学, 理工学部　応用化学科, 専任講師

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Academic Background 【 Display / hide 】

  • 2003.04
    -
    2007.03

    Keio University, 理工学部, 応用化学科

    University, Graduated

  • 2007.04
    -
    2009.03

    慶應義塾大学大学院, 理工学研究科, 生物化学専修

    Graduate School, Master's course

  • 2009.04
    -
    2012.03

    慶應義塾大学大学院, 理工学研究科, 生物化学専修

    Graduate School, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（工学）, Keio University, Coursework, 2012.03

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Books 【 Display / hide 】

  • 高分子微粒子の最新技術動向

    シーエムシー出版, 2022.07

    Scope: 高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

  • 高分子基礎ガイド

    藤本啓二, 川口正剛, 小泉智, 福井有香, 箕田雅彦, 本柳仁, 朝倉書店, 2022.02,  Page： 153

  • 高分子微粒子のつくり方と活かし方

    藤本啓二, 福井有香, 塗装工学 (一般社団法人 日本塗装技術協会) 54 ( 11 ) , 2019.11,  Page： 394 - 403

  • ドラッグデリバリーシステム・バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発

    福井有香, 藤本啓二, シーエムシー出版, 2018.08

    Scope: リポソームの表面改質によるナノカプセルの作製と機能化,  Contact page： 195-206

  • 中空微粒子の合成と応用

    FUKUI YuukaFUJIMOTO Keiji, シーエムシー出版, 2017

    Scope: リポソームを鋳型とした中空微粒子の合成

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Papers 【 Display / hide 】

  • Functionalization of keratin nanoparticles by their internal modifications

    Yuuka Fukui, Kaori Ito, Keiji Fujimoto

    Polymer Journal （Springer Nature)   2022.06

    Research paper (scientific journal), Joint Work, Corresponding author, Accepted,  ISSN  00323896

    　View Summary

    We prepared keratin nanoparticles, which could respond to temperature and pH changes and to redox reactions, by electrostatic association of keratin and a cationic surfactant, dioctadecyl dimethyl ammonium chloride (DODAC). Solubilized keratin chains were assembled into nanoparticles (Ker-DODAC) and then crosslinked by disulfide formation. The resultant nanoparticles (Ker-DODACss) possessed a hydrophobic core composed of DODAC, enabling hydrophobic compounds to be loaed and retained in the core. By increasing the temperature, the fluidity of the core was increased, resulting in Ker-DODACss swelling and burst release of loaded compounds. Next, cholesterol was loaded into Ker-DODACss to modify the inner environment, such as the hydrophobicity and fluidity of the core. The nanoparticles (Ker-DODACss-Chol) exhibited reduced fluidity of the core and suppressed release of the payload. Furthermore, the release could be triggered by decreasing the electrostatic interaction between keratin and DODAC at pH values lower than 7.4. It was also found that Ker-DODACss-Chol possessed the ability to release payloads by breaking disulfide bonds. As a further internal modification, we incorporated a lipophilic antioxidant, α-tocopherol, into Ker-DODACss-Chol. It was confirmed that Ker-DODACss-Chol could act as a physical barrier to prevent α-tocopherol from undergoing oxidative degradation.

  • Preparation of a deformable nanocapsule by living radical polymerization in a liposome

    Fukui Y., Fukui A., Fujimoto K.

    Polymer Journal （Polymer Journal)  54 （ 7 ） 893 - 901 2022

    ISSN  00323896

    　View Summary

    We aimed to prepare an elastic nanocapsule by internal modification of a liposome with living radical polymerization. First, monomers and photoiniferters were encapsulated in liposomes. Then, UV light irradiation was used to conduct living radical polymerization in the liposomes. The obtained nanocapsules showed good absorption and retention of chemical substances depending on the binding ability to the incorporated polymers, and the absorption capacity could be controlled by the length and dissolved state of the polymer chains. In addition, dynamic morphological changes in the capsules were observed when liposomes with high membrane fluidity were employed. Morphological changes in the nanocapsules were induced by altering the pH value and ionic strength, resulting in the release of cargo in response to these environmental conditions.

  • Preparation of agarose xerogel nanoparticles by solvent evaporation from water nanodroplets

    Fukui Y., Inamura R., Fujimoto K.

    Polymer Journal （Polymer Journal)  53 （ 7 ） 815 - 821 2021.07

    ISSN  00323896

    　View Summary

    We developed a W/O miniemulsion reactor system enabling the preparation of biopolymer nanoparticles and control of their morphologies and inner microstructures. First, the W/O miniemulsion was prepared by suspending water nanodroplets containing agarose in oil. Then, we produced agarose hydrogel nanoparticles (AgarH) by the gelation of agarose in nanodroplets. Next, we prepared agarose xerogel nanoparticles (AgarX) by precisely tuning the water evaporation from AgarH. We controlled the morphologies (solid and hollow) and crystal structure of AgarX by changing the pressure and temperature during water evaporation. In fact, AgarX with a hollow structure was generated through rapid evaporation at a low pressure. AgarH was dissolved in Milli-Q water when the temperature was raised to 90 °C. On the other hand, AgarX remained a solid particle under the same conditions, likely because of its high crystallinity. We expect that this technique can be applied to prepare xerogels of diverse biomass-based polymers for the replacement of synthetic polymers.

  • Creation of porous polymeric membranes by accumulation of water nanodroplets in a miniemulsion system

    Fukui Y., Fujino R., Sugaya Y., Fujimoto K.

    Polymer Journal （Polymer Journal)  52 （ 9 ） 1077 - 1083 2020.09

    ISSN  00323896

    　View Summary

    © 2020, The Society of Polymer Science, Japan. We developed a miniemulsion templating method to prepare porous polymeric membranes. First, water nanodroplets were suspended in an oil phase by using a nonionic and polymeric surfactant to form a water-in-oil (W/O) miniemulsion. After the nanodroplets accumulated by centrifugation, a small amount of monomer was added as an oil phase to resuspend the water nanodroplets in a monomer phase. Then, photopolymerization of the monomer phase was conducted to generate pores in the polymeric matrix. The size of the nanodroplets was tuned by the surfactant concentration to control the pore size of the membranes. We could produce pore morphologies such as closed-cellular, open-cellular, and bicontinuous structures by tuning the volume fraction of the nanodroplets. Alternatively, nanodroplets were accumulated by centrifugation, and then further surfactants were added to the monomer to suppress the coalescence of nanodroplets. This enabled us to generate a highly porous open-cellular structure while maintaining the size and spherical shape. Next, HAuCl4 was reduced by using the surfactant displayed at the inner surface of the pore wall as the reducing agent. Gold nanoparticles were produced in the inner pores of the polymeric membrane, showing coloration derived from local surface plasmon resonance.

  • Tuning of particle indentation by surface modification of polymer particles and substrates

    Fukui Y., Yamamoto K., Yamamoto T., Fujimoto K.

    Colloids and Surfaces A: Physicochemical and Engineering Aspects （Colloids and Surfaces A: Physicochemical and Engineering Aspects)  588 2020.03

    ISSN  09277757

    　View Summary

    © 2019 Elsevier B.V. We studied the influence of the chemical properties of the polymer particle and the polymer substrate on particle indentation. The polymer particles were arrayed over the polymer substrate and heat treatment (annealing) was conducted above the glass transition temperature (Tg) of bulk polymer to indent polymer particles into the polymer substrate. Surface topologies of particle-indented surfaces were observed with a field-emission scanning electron microscope (FE-SEM) and the degree of particle indentation (DI) was evaluated with a scanning probe microscope (SPM). The particle-arrayed substrate was placed upside down and then heat treatment was carried out. It was found that there was no effect of gravity on particle indentation. To prepare polymer particles with different chemical properties, surface grafting of hydrophobic, hydrophilic, cationic and anionic polymer chains was carried out by iniferter-initiated living radical polymerization. We found that the indentation of these particles was influenced by the outermost surface of the particle. Next, to investigate the effect of the substrate surface on particle indentation, sulfonation of the polystyrene (PS) substrate was carried out with concentrated sulfuric acid. We found that the surface property of the substrate also influenced particle indentation. From these results, we concluded that particle indentation would be determined by the interaction between the particle surface and the substrate surface. Finally, we intended to analyze the viscoelastic property of the substrate surface by particle indentation. We could estimate Tg values of PS and polyvinyl chloride (PVC) substrates by observing the particle indentation at the different annealing temperatures.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ミネラル層で覆われたリポナノカプセルの創製

    福井有香

    PHARM STAGE (技術情報協会 )  18 ( 5 )  2018.08

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • 機能性高分子微粒子の合成と作製技術

    福井有香, 藤本啓二

    MATERIAL STAGE (技術情報協会 )  18 ( 2 ) 1 - 6 2018

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • Preparation of agarose xerogel nanoparticles by solvent evaporation from water nanodroplets

    福井有香, 稲村隆太郎, 藤本啓二

    第71回高分子学会年次大会, 

    2022.05
    , 

    Oral presentation (invited, special)

  • Controlled functionalization of biopolymer-deposited liposomes by the enzymatic degradation

    Yuuka Fukui, Hikari Otsuka, Keiji Fujimoto

    Pacifichem 2021, 

    2021.12
    , 

    Oral presentation (general)

  • リポソーム内部へのDNA封入とミネラル化による機能創出

    浅野いぶき, 福井有香, 藤本啓二

    第43回日本バイオマテリアル学会大会, 

    2021.11
    , 

    Poster presentation

  • 多糖と酵素を積層化したセラミド含有リポナノカプセルの創製

    伊藤純名, 福井有香, 藤本啓二

    第43回日本バイオマテリアル学会大会, 

    2021.11
    , 

    Poster presentation

  • ミニエマルションによる酵素被覆ナノ粒子の作製とH2O2生成の制御

    瀬戸隆継, 福井有香, 藤本啓二

    第43回日本バイオマテリアル学会大会, 

    2021.11
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 骨疾患治療のための骨環境応答性ナノツールの開発

    2019.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

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Awards 【 Display / hide 】

  • 2021年度Polymer Journal論文賞-日本ゼオン賞

    2022.05, 公益社団法人 高分子学会

    Type of Award： Award from Japanese society, conference, symposium, etc.

    　View Description

    論文「ナノサイズの水滴を反応場としたバイオマス高分子微粒子作製技術の開発」が評価されたことによる

  • The Young Investigator Award Gold Prize(11th Liposome Research Days Conference)

    FUKUI Yuuka, 2008.07, Preparation of Lipo-nanocapsules by the layer-by-layer deposition of polysaccharides and coating of calcium phosphate onto a liposome

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • SEMINAR IN APPLIED CHEMISTRY

    2022

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2022

  • LABORATORIES IN APPLIED CHEMISTRY D

    2022

  • FRONTIER OF CHEMISTRY

    2022

  • BACHELOR'S THESIS

    2022

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Memberships in Academic Societies 【 Display / hide 】

  • Materials Research Society, 

    2011.11
    -
    Present

  • American Chemical Society, 

    2009.05
    -
    Present

  • 日本バイオマテリアル学会, 

    2007.11
    -
    Present

  • 高分子学会, 

    2007.05
    -
    Present
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