Fukui, Yuuka

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry (Yagami)

Position

Associate Professor

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Career 【 Display / hide 】

  • 2015.04
    -
    2017.03

    慶應義塾大学, 理工学部　応用化学科, 助教

  • 2017.04
    -
    2023.03

    慶應義塾大学, 理工学部　応用化学科, 専任講師

  • 2023.04
    -
    Present

    Keio University, 理工学部　応用化学科, Associate Professor

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Academic Background 【 Display / hide 】

  • 2003.04
    -
    2007.03

    Keio University, 理工学部, 応用化学科

    University, Graduated

  • 2007.04
    -
    2009.03

    慶應義塾大学大学院, 理工学研究科, 生物化学専修

    Graduate School, Master's course

  • 2009.04
    -
    2012.03

    慶應義塾大学大学院, 理工学研究科, 生物化学専修

    Graduate School, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（工学）, Keio University, Coursework, 2012.03

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Polymer chemistry (コロイド・界面化学、微粒子材料、DDS、バイオマテリアル、グリーンマテリアル)

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Books 【 Display / hide 】

  • 高分子微粒子の最新技術動向

    シーエムシー出版, 2022.07

    Scope: 高分子微粒子の構造・配列・付着・埋没・ナノインプリントを利用した表面改質

  • 高分子基礎ガイド

    藤本啓二, 川口正剛, 小泉智, 福井有香, 箕田雅彦, 本柳仁, 朝倉書店, 2022.02,  Page： 153

  • 高分子微粒子のつくり方と活かし方

    藤本啓二, 福井有香, 塗装工学 (一般社団法人 日本塗装技術協会) 54 ( 11 ) , 2019.11,  Page： 394 - 403

  • ドラッグデリバリーシステム・バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発

    福井有香, 藤本啓二, シーエムシー出版, 2018.08

    Scope: リポソームの表面改質によるナノカプセルの作製と機能化,  Contact page： 195-206

  • 中空微粒子の合成と応用

    FUKUI YuukaFUJIMOTO Keiji, シーエムシー出版, 2017

    Scope: リポソームを鋳型とした中空微粒子の合成

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Papers 【 Display / hide 】

  • Preparation of a CNF porous membrane and in situ synthesis of silver nanoparticles (AgNPs)

    Yuuka Fukui, Eriko Baba, Keiji Fujimoto

    RSC Advances (Royal Society of Chemistry)  15 ( 2 ) 1115 - 1124 2025.01

    Research paper (scientific journal), Joint Work, Lead author, Corresponding author, Accepted

    　View Summary

    We prepared a cellulose nanofiber (CNF)-based porous membrane with three dimensional cellular structures. CNF was concentrated via a surfactant-induced assembly by mixing CNF with a cationic surfactant, domiphen bromide (DB). Furthermore, they were accumulated by centrifugation to obtain a CNF-DB sol. Next, when the CNF-DB sol was naturally dried, a membrane composed of densely packed CNF was obtained. On the other hand, when the CNF-DB sol was freeze-dried, a porous membrane with the anisotropic cellular structure could be obtained. The interspace between layered CNF sheets was tunable by the DB concentration in the assembly process and the centrifugal force in the accumulation process. FT-IR analysis of the porous membrane showed the formation of hydrogen bonds between the CNF, resulting in facilitation of crosslinking of the CNF and formation of the cellular structures. The obtained CNF-DB membrane exhibited high water resistance. They showed a high ability to absorb hydrophobic dyes such as Nile red and rhodamine B (RhB) due to the presence of the hydrophobic core of DB micelles. Then, the release of RhB could be controlled by the ionic strength in the medium. In addition, they possessed a high ability to adsorb cationic metals such as Ag ions due to the presence of carboxyl moieties of CNF. Next, in situ synthesis of silver nanoparticles (AgNPs) was carried out by employing the CNF-DB membrane as a template for Ag ion adsorption and reduction. Deposition of AgNPs could be observed on the CNF-DB membrane, which suppressed aggregation of AgNPs. Almost all AgNPs were arrayed apart from each other to generate the hotspots, which could enhance surface-enhanced Raman scattering (SERS) of AgNPs. Such an AgNPs-CNF composite membrane could be applied for a label-free analysis of adsorbed RhB.

  • Preparation of a robust and degradable nanocapsule by polymer deposition over the liposome for loading and release of cargos

    Fukui Y., Ito J., Takeiri M., Fujimoto K.

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids and Surfaces A: Physicochemical and Engineering Aspects)  676 2023.11

    ISSN  09277757

    　View Summary

    We prepared biobased nanocapsules by the polymer deposition over the ceramide-containing liposomes to render abilities to load versatile substances and to release them in response to enzymatic degradation of the capsule wall. First, we carried out phosphorylation of chitosan (CHI) to make it amphoteric. Then, we prepared a liposome containing glucosylceramide (GlcCer) and carried out deposition of phosphorylated chitosan (PCHI). The obtained capsule showed high structural stability against solubilization by surfactants and organic solvents, where it maintained its size even in 90 vol% DMSO. Next, we attempted to load various substances into the capsule. A lipophilic Nile red dissolved in 50 vol% DMSO could be loaded into the capsule without rupturing. The loading capacity of PCHI-deposited liposomes was almost three times higher than that of bare liposomes. Its release was suppressed to less than 10 % in an aqueous solution, whereas it could be released to more than 40 % when a small amount of surfactant was added to mimic a lipophilic environment. Also, an amphoteric nature of the capsule derived from PCHI allowed for loading of both cationic and anionic substances. Furthermore, lysozyme (Lyso) was deposited onto the capsule to provide the capsule wall with the enzymatic degradability. Although the release of substances from the capsule was suppressed to less than 10 % without Lyso, it was increased to approximately 50 % by enzymatic degradation of the PCHI layer.

  • One-pot generation of gold-polymer hybrid nanoparticles using a miniemulsion reactor system

    Yuuka Fukui, Kaori Fujino, Keiji Fujimoto

    Colloids and Surfaces A: Physicochemical and Engineering Aspects (Elsevier)  666 2023.06

    Research paper (scientific journal), Joint Work, Corresponding author, Accepted,  ISSN  09277757

    　View Summary

    We investigated one-pot synthesis of gold nanoparticles (AuNPs) and AuNPs-polymer hybrid nanoparticles in a water-in-oil (W/O) miniemulsion. Water nanodroplets were dispersed as a reactor in cyclohexane using dimethicone as a surfactant. First, we intended to generate AuNPs in water nanodroplets, which contained HAuCl4 with a mixture of 1-vinylpyrrolidone (VP) and N,N’-methylenebisacrylamide (MBAAm). Several AuNPs with the size of approximately 10–20 nm were generated in each nanodroplet via reduction of AuCl4- by dimethicone. On the other hand, AuNPs was scarcely generated in water nanodroplets containing HAuCl4 with 2-hydroxyethyl methacrylate (HEMA). Next, we carried out polymerization in water nanodroplets to encapsulate AuNPs into polymer nanoparticles. Several AuNPs were encapsulated within polymer particles by copolymerization of VP and MBAAm with an oil-soluble initiator (V-601), and some AuNPs were present in the oil phase. The encapsulation efficiency of AuNPs was 34%. The encapsulation efficiency of AuNPs was dramatically increased by increasing the concentration of the initiator. The same result was obtained by increasing the concentration of the crosslinker due to rapid gelation of nanodroplets. On the other hand, monodisperse particles could be obtained by polymerization of HEMA using a water-soluble initiator (V-65). After polymerization for 5 d at 65ºC, the color of the suspension changed from opaque blue to blue purple and the encapsulation efficiency of AuNPs (5–20 nm) increased to 99 wt%. The average number of AuNPs encapsulated in a PHEMA nanoparticle increased from 1.5 to 4.6 particle. Furthermore, the size of AuNPs could be tuned by increasing the HAuCl4 concentration, and the corresponding color of the suspensions such as blue, purple, and red could be observed. The number and location of AuNPs in polymer nanoparticles could also be tuned by additives such as L-histidine and polyvinylpyrrolidone. By drop-casting the obtained hybrid nanoparticles, we could obtain gold-polymer hybrid films where AuNPs were evenly distributed within a film. The films exhibited different colors corresponding to their LSPR of AuNPs.

  • Control in Coloration and Estimation of the Refractive Index by Porous Polymeric Membranes Prepared by the "Miniemulsion" Templating Method

    Fukui Y., Sumida H., Sugaya Y., Fujimoto K.

    ACS Applied Polymer Materials (ACS Applied Polymer Materials)  4 ( 10 ) 7547 - 7553 2022.10

    　View Summary

    We fabricated porous polymeric membranes using the miniemulsion templating method to investigate the transmitted and scattered lights in terms of the Christiansen filter effect. This method made it possible to produce porous polymeric membranes with different refractive indices by polymerization of different monomers and copolymerization of monomers. When a membrane with an open-cellular structure was immersed in a liquid, the transmitted light was observed at a wavelength where the refractive indices of the polymeric phase and the liquid matched. Angle-independent color derived from the scattered light could also be observed. When the porous membrane of poly(2-ethylhexyl methacrylate) (EHMA) was immersed in a mixture of different kinds of liquids, the maximum wavelength of the transmission (λmax) changed according to the refractive index matching of the polymeric phase and the liquid, resulting in the change in coloration. Next, when the P(EHMA-co-EGDMA) membrane was immersed in a mixture of toluene and d-limonene, λmax and color varied depending on their mixing ratios. This coloration was controlled by temperature and the refractive indices of the polymeric phase and the liquid. Furthermore, we could estimate the refractive index of PEGDMA using λmax values obtained by immersing it into liquids with different refractive indices.

  • Functionalization of keratin nanoparticles by their internal modifications

    Yuuka Fukui, Kaori Ito, Keiji Fujimoto

    Polymer Journal (Springer Nature)  54 ( 11 ) 1367 - 1375 2022.06

    Research paper (scientific journal), Joint Work, Corresponding author, Accepted,  ISSN  00323896

    　View Summary

    We prepared keratin nanoparticles, which could respond to temperature and pH changes and to redox reactions, by electrostatic association of keratin and a cationic surfactant, dioctadecyl dimethyl ammonium chloride (DODAC). Solubilized keratin chains were assembled into nanoparticles (Ker-DODAC) and then crosslinked by disulfide formation. The resultant nanoparticles (Ker-DODACss) possessed a hydrophobic core composed of DODAC, enabling hydrophobic compounds to be loaed and retained in the core. By increasing the temperature, the fluidity of the core was increased, resulting in Ker-DODACss swelling and burst release of loaded compounds. Next, cholesterol was loaded into Ker-DODACss to modify the inner environment, such as the hydrophobicity and fluidity of the core. The nanoparticles (Ker-DODACss-Chol) exhibited reduced fluidity of the core and suppressed release of the payload. Furthermore, the release could be triggered by decreasing the electrostatic interaction between keratin and DODAC at pH values lower than 7.4. It was also found that Ker-DODACss-Chol possessed the ability to release payloads by breaking disulfide bonds. As a further internal modification, we incorporated a lipophilic antioxidant, α-tocopherol, into Ker-DODACss-Chol. It was confirmed that Ker-DODACss-Chol could act as a physical barrier to prevent α-tocopherol from undergoing oxidative degradation.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ポリマーとの複合化によるリポソームの機能創出の試み

    藤本啓二、福井有香

    月刊ファインケミカル ((株)シーエムシー出版)   2025.05

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author

  • ミネラル層で覆われたリポナノカプセルの創製

    福井有香

    PHARM STAGE (技術情報協会 )  18 ( 5 )  2018.08

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • 機能性高分子微粒子の合成と作製技術

    福井有香, 藤本啓二

    MATERIAL STAGE (技術情報協会 )  18 ( 2 ) 1 - 6 2018

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • 内部改質リポソームの集積化と貼付型製剤に向けた機能化

    福井 有香, 青木 優美, 藤本 啓二

    第 53 回医用高分子シンポジウム (産業技術総合研究所 臨海副都心センター 別館 11 階会議室) , 

    2024.07
    , 

    Oral presentation (general), 高分子学会 医用高分子研究会

  • 微小な液滴を用いた高分子コロイドの創製

    福井　有香

    第9回バイオ関連デザイン研究会 (静岡大学　浜松キャンパス) , 

    2024.03
    , 

    Oral presentation (invited, special), 公益社団法人　日本セラミックス協会

  • Bio-inspired Preparation of Polymeric Nanoparticles and Porous Membranes by Using Nanodroplets as a Template

    Yuuka Fukui

    6th G‘L’owing Polymer Symposium in KANTO, 

    2023.11
    , 

    Oral presentation (invited, special)

  • リポソームをテンプレートとした 多機能ナノカプセルの開発

    福井　有香

    第 45 回日本バイオマテリアル学会大会, 

    2023.11
    , 

    Oral presentation (invited, special)

  • Preparation of ceramide-containing liponano-capsules by polymer deposition for versatile loading and self-degradation

    Yuuka Fukui, Junna Ito, Masatoshi Takeiri, Koki Hatayama, Yoshihide Kimura, Keiji Fujimoto

    72nd SPSJ Annual Meeting, 

    2023.05
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 経皮薬物送達システムを指向したリポソーム型ナノカプセルの開発

    2024.04
    -
    2027.03

    基盤研究(C), Principal investigator

  • 骨疾患治療のための骨環境応答性ナノツールの開発

    2019.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

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Awards 【 Display / hide 】

  • 2023年度日本バイオマテリアル学会科学奨励賞

    福井　有香, 2023.07, 一般財団法人日本バイオマテリアル学会, リポソームをテンプレートとした多機能ナノカプセルの開発

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 第58回リバネス研究費　東洋紡高分子科学賞

    2023.03

    Type of Award： Award from publisher, newspaper, foundation, etc.

  • 2021年度Polymer Journal論文賞-日本ゼオン賞

    2022.05, 公益社団法人 高分子学会

    Type of Award： Award from Japanese society, conference, symposium, etc.

    　View Description

    論文「ナノサイズの水滴を反応場としたバイオマス高分子微粒子作製技術の開発」が評価されたことによる

  • The Young Investigator Award Gold Prize(11th Liposome Research Days Conference)

    FUKUI Yuuka, 2008.07, Preparation of Lipo-nanocapsules by the layer-by-layer deposition of polysaccharides and coating of calcium phosphate onto a liposome

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • SEMINAR IN APPLIED CHEMISTRY

    2025

  • POLYMER AND COLLOID CHEMISTRY

    2025

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2025

  • LABORATORIES IN APPLIED CHEMISTRY D

    2025

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2025

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Memberships in Academic Societies 【 Display / hide 】

  • Materials Research Society, 

    2011.11
    -
    Present

  • American Chemical Society, 

    2009.05
    -
    Present

  • 日本バイオマテリアル学会, 

    2007.11
    -
    Present

  • 高分子学会, 

    2007.05
    -
    Present
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