Toshima, Kazunobu

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry (Yagami)

Position

Professor

Related Websites

External Links
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Career 【 Display / hide 】

  • 1988.04
    -
    1989.03

    ペンシルバニア大学化学科 ,博士研究員

  • 1989.04
    -
    1994.03

    慶應義塾大学（理工学部） ,助手

  • 1994.04
    -
    1996.03

    慶應義塾大学（理工学部） ,専任講師

  • 1996.04
    -
    2003.03

    慶應義塾大学理工学部（応用化学科）,助教授

  • 1997.04
    -
    1999.03

    慶應義塾大学理工学応用化学科教室幹事

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Academic Background 【 Display / hide 】

  • 1983.03

    Keio University, Faculty of Engineering, 応用化学科

    University, Graduated

  • 1985.03

    Keio University, Graduate School, Division of Engineering, 応用化学専攻

    Graduate School, Completed, Master's course

  • 1988.03

    Keio University, Graduate School, Division of Science and Engineeri, 応用科学専攻

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 工学　, Keio University, 1988.03

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Synthetic organic chemistry

  • Nanotechnology/Materials / Bio chemistry

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  • Nanotechnology/Materials / Chemical biology

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Books 【 Display / hide 】

  • Modern Natural Product Synthesis -Overcoming Difficulties

    *Daisuke Takahashi, *Kazunobu Toshima , Springer Nature , 2024.05,  Page： 20

    Scope: Complex Oligosaccharides Synthesis—Challenges and Tactics,  Contact page： 299-318

  • Comprehensive Glycoscience 2nd edition

    Daisuke Takahashi, Kazunobu Toshima, Elsevier, 2021.06

    Scope: 1,2-cis O-Glycosylation methods, Vol. 2, pp. 365-412.

  • 標的糖鎖光分解用生体機能分子、糖鎖の新機能開発・応用ハンドブック

    TAKAHASHI DAISUKE,TOSHIMA KAZUNOBU, エヌ・ティー・エス, 2015.08

    Scope: 377-379

  • 環境調和型グリコシル化反応、 糖鎖の新機能開発・応用ハンドブック

    SASAKI KANAME,TAKAHASHI DAISUKE,TOSHIMA KAZUNOBU, エヌ・ティー・エス, 2015.08

    Scope: 339-342

  • Stereoselective formation of 2-deoxyglycosidic bonds in biologically active natural products

    TAKAHASHI DAISUKE, TOSHIMA KAZUNOBU, Wiley, 2013

    Scope: 1137-1171

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Papers 【 Display / hide 】

  • Photo-induced glycosylation using edible polyphenol ellagic acid

    Hidenari Shigeta, Satomi Goi, Daisuke Takahashi, *Kazunobu Toshima

    Carbohydrate Research (Elsevier )  552   109461 2025.03

    Research paper (scientific journal), Last author, Corresponding author, Accepted

  • Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium Using Late-stage Boron-mediated Aglycon Delivery

    Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, *Masayuki Igarashi, *Takeshi Yokoyama, *Kazunobu Toshima, *Daisuke Takahashi

    Science Advances (American Association for the Advancement of Science)  11 ( 10 ) eadt2352 2025.03

    Research paper (scientific journal), Corresponding author, Accepted

  • A novel porphyrin-based theranostic agent activated by cysteine over-expressed in cancer cells shows promise for tumour-targeted monitoring and phototherapy

    Fumihisa Ishida, Satoe Moriya, Daisuke Takahashi, *Kazunobu Toshima

    Bioorganic & Medicinal Chemistry (Elsevier)  121   118131 2025.02

    Research paper (scientific journal), Last author, Corresponding author, Accepted

  • Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection

    Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba, Shuhei Kosono, Maniyamma Aswathy, Itsuki Anzai, Tokiko Watanabe, *Kazunobu Toshima, *Daisuke Takahashi

    Angewandte Chemie International Edition (Wiley-VCH)  64 ( 6 ) e202411760 2024.10

    Research paper (scientific journal), Corresponding author, Accepted

  • A novel photosensitizer based on hypocrellin B activated by cysteine over-expressed in cancer cells

    Fumihisa Ishida, Rikuto Onishi, Daisuke Takahashi, *Kazunobu Toshima

    Organic & Biomolecular Chemistry (Royal Society of Chemistry)  22   7187 - 7193 2024.08

    Research paper (scientific journal), Last author, Corresponding author, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 高機能性化粧品素材の創製を指向したマンノシルエリスリトールリピッド（MEL）類縁体の合成と構造活性相関研究

    孟継坤, *戸嶋一敦, *高橋大介

    オレオサイエンス 24 ( 11 ) 475 - 481 2024.11

    Article, review, commentary, editorial, etc. (scientific journal), Corresponding author

  • ホウ素媒介アグリコン転移反応の新展開:反応開発,有用糖質合成,およびケミカルバイオロジーへの応用

    *高橋大介, *戸嶋一敦

    有機合成化学協会誌 82 ( 9 ) 856 - 866 2024.09

    Article, review, commentary, editorial, etc. (scientific journal), Last author, Corresponding author

  • Total Synthesis of Mannosylerythritol Lipids and Structure-Function Relationship Studies

    *Daisuke Takahashi, Kazunobu Toshima

    Journal of Oleo Science  73卷 ( 4号 ) 539頁 - 546頁 2024.04

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author

  • Photo-Induced Glycosylations Using Organophotoacids: A New Environmentally Benign Carbohydrate Synthesis

    *Kazunobu Toshima, Daisuke Takahashi, Yuka Isozaki

    Synlett  35卷   777頁 - 788頁 2023.07

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author

  • Boron-mediated aglycon delivery (BMAD) for the stereoselective synthesis of 1,2-cis glycosides

    *Daisuke Takahashi, Kazunobu Toshima

    Advances in Carbohydrate Chemistry and Biochemistry 82   79 - 105 2022.11

    Article, review, commentary, editorial, etc. (scientific journal), Last author

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Presentations 【 Display / hide 】

  • Synthesis of Mannosylerythritol Lipid-Containing LNPs and Their Nucleotide Delivery Activities

    〇Misuzu Iha, Itsuki Anzai, Tokiko Watanabe, Kotomi Aso, Yuuya Kasahara, Kazunobu Toshima, Daisuke Takahashi

    [Domestic presentation]  日本化学会 第105春季年会 (関西大学 千里山キャンパス ) , 

    2025.03
    , 

    Oral presentation (general)

  • Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium by Late-stage Boron-mediated Aglycon Delivery

    〇Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Maho Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, Masayuki Igarashi, Takeshi Yokoyama, Kazunobu Toshima, Daisuke Takahashi

    [Domestic presentation]  日本化学会 第105春季年会 (関西大学 千里山キャンパス ) , 

    2025.03
    , 

    Oral presentation (general)

  • Development of Microwave-Controlled Boron-Mediated Aglycon Delivery and Total Synthesis of Plant Hormone CLE2

    〇Kazuki Senoo, Kazuki Inaba, Ayato Takayanagi, Yuji Wada, Makoto Yasuda, Kazunobu Toshima, Daisuke Takahashi

    [Domestic presentation]  日本化学会 第105春季年会 (関西大学 千里山キャンパス) , 

    2025.03
    , 

    Oral presentation (general)

  • 可食性ポリフェノールシナピン酸を活性化剤に用いた環境調和型光グリコシル化反応の開発

    ◯白石 知佳子, 高橋 大介, 戸嶋 一敦

    GlycoTOKYO2024 (創価大学　大教室棟（S棟）) , 

    2024.11
    , 

    Poster presentation, 東京糖鎖研究会

  • フコイダン類縁体のデングウイルス感染阻害活性

    〇島田 澪, 下岡 誠, 安齋 樹, 渡辺 登喜子, 戸嶋 一敦, 高橋 大介

    [Domestic presentation]  GlycoTOKYO2024 (創価大学　大教室棟（S棟）) , 

    2024.11
    , 

    Poster presentation, 東京糖鎖研究会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 天然物を基本骨格とする刺激応答型光感受性分子の創製と次世代型光線力学療法への応用

    2022.04
    -
    2026.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(B), Principal investigator

  • 機能複合化による生体機能光制御中分子の創製

    2016.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • Creation of agents that selectively photo-degrade certain proteins and oligosaccharides and its application to control of cell functions

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

    　View Summary

    Several agents, that target-selectively photo-degrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the agents thus developed work not only in test tube but also in disease-related cells. From these studies, a new approach for the design of light-activated and molecular-targeted medicines has been established.

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 抗腫瘍活性を有する硫酸化オリゴフコシド類

    Date applied： 特願2013-150907  2013.07 

    Patent, Joint

  • ノイラミニダーゼに対する酵素阻害剤

    Date applied： 特願2010-022168  2009.02 

    Patent, Joint

  • 光増感剤、タンパク質切断剤、タンパク質切断方法、糖分子切断剤、糖分子切断方法、及び光線力学治療剤

    Date applied： 特願2007-507210  2006.03 

    Date issued： 特許第5046029号  2012.07

    Patent, Single

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Awards 【 Display / hide 】

  • 義塾賞

    2024.11

  • SSOCJ Daiichi-Sankyo Award for Medicinal Organic Chemistry 2015

    2016.02

  • 日本化学会学術賞

    2015.03

  • 山下太郎学術研究奨励賞

    1996.05

  • 日本化学会進歩賞

    1995.03

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Courses Taught 【 Display / hide 】

  • SEMINAR IN APPLIED CHEMISTRY

    2025

  • MOLECULAR LIFE CHEMISTRY 1

    2025

  • LABORATORIES IN APPLIED CHEMISTRY D

    2025

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2025

  • GRADUATE RESEARCH ON FUNDAMENTAL SCIENCE AND TECHNOLOGY 2

    2025

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Memberships in Academic Societies 【 Display / hide 】

  • 日本ケミカルバイオロジー学会, 

    2007.04
    -
    Present

  • 高分子学会, 

    2004.07
    -
    Present

  • 日本糖質学会, 

    1991.03
    -
    Present

  • アメリカ化学会, 

    1988.06
    -
    Present

  • 有機合成化学協会, 

    1986.01
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2014.11
    -
    Present

    幹事, GlycoTokyo

  • 2014.04
    -
    Present

    評議員, 日本糖質学会

  • 2007.04
    -
    Present

    世話人, 日本ケミカルバイオロジー学会

  • 2006.04
    -
    2008.03

    関東支部常任幹事, 有機合成化学協会

  • 2006.04
    -
    2008.03

    事業委員会委員, 有機合成化学協会

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