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Affiliation
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Faculty of Science and Technology, Department of Applied Chemistry (Yagami)
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Position
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Professor
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Related Websites
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External Links
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Toshima, Kazunobu
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Career 【 Display / hide 】
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1988.04-1989.03
ペンシルバニア大学化学科 ,博士研究員
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1989.04-1994.03
慶應義塾大学（理工学部） ,助手
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1994.04-1996.03
慶應義塾大学（理工学部） ,専任講師
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1996.04-2003.03
慶應義塾大学理工学部（応用化学科）,助教授
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1997.04-1999.03
慶應義塾大学理工学応用化学科教室幹事
Academic Background 【 Display / hide 】
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1983.03
Keio University, Faculty of Engineering, 応用化学科
University, Graduated
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1985.03
Keio University, Graduate School, Division of Engineering, 応用化学専攻
Graduate School, Completed, Master's course
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1988.03
Keio University, Graduate School, Division of Science and Engineeri, 応用科学専攻
Graduate School, Completed, Doctoral course
Research Areas 【 Display / hide 】
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Nanotechnology/Materials / Synthetic organic chemistry
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Nanotechnology/Materials / Bio chemistry
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Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules
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Nanotechnology/Materials / Chemical biology
Books 【 Display / hide 】
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Modern Natural Product Synthesis -Overcoming Difficulties
*DAISUKE TAKAHASHI, *Kazunobu Toshima , Springer Nature , 2024.05, Page： 20
Scope: Complex Oligosaccharides Synthesis—Challenges and Tactics, Contact page： 299-318
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Comprehensive Glycoscience 2nd edition
DAISUKE TAKAHASHI, Kazunobu Toshima, Elsevier, 2021.06
Scope: 1,2-cis O-Glycosylation methods, Vol. 2, pp. 365-412.
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標的糖鎖光分解用生体機能分子、糖鎖の新機能開発・応用ハンドブック
TAKAHASHI DAISUKE,TOSHIMA KAZUNOBU, エヌ・ティー・エス, 2015.08
Scope: 377-379
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環境調和型グリコシル化反応、 糖鎖の新機能開発・応用ハンドブック
SASAKI KANAME,TAKAHASHI DAISUKE,TOSHIMA KAZUNOBU, エヌ・ティー・エス, 2015.08
Scope: 339-342
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Stereoselective formation of 2-deoxyglycosidic bonds in biologically active natural products
TAKAHASHI DAISUKE, TOSHIMA KAZUNOBU, Wiley, 2013
Scope: 1137-1171
Papers 【 Display / hide 】
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Photo-induced glycosylation using edible polyphenol ellagic acid
Hidenari Shigeta, Satomi Goi, DAISUKE TAKAHASHI, *Kazunobu Toshima
Carbohydrate Research (Elsevier ) 552 109461 2025.03
Research paper (scientific journal), Accepted
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Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium Using Late-stage Boron-mediated Aglycon Delivery
Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, *Masayuki Igarashi, *Takeshi Yokoyama, *Kazunobu Toshima, *DAISUKE TAKAHASHI
Science Advances (American Association for the Advancement of Science) 11 ( 10 ) eadt2352 2025.03
Research paper (scientific journal), Last author, Corresponding author, Accepted
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A novel porphyrin-based theranostic agent activated by cysteine over-expressed in cancer cells shows promise for tumour-targeted monitoring and phototherapy
Fumihisa Ishida, Satoe Moriya, DAISUKE TAKAHASHI, *Kazunobu Toshima
Bioorganic & Medicinal Chemistry (Elsevier) 121 118131 2025.02
Research paper (scientific journal), Accepted
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Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection
Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba, Shuhei Kosono, Maniyamma Aswathy, Itsuki Anzai, Tokiko Watanabe, *Kazunobu Toshima, *DAISUKE TAKAHASHI
Angewandte Chemie International Edition (Wiley-VCH) 64 ( 6 ) e202411760 2024.10
Research paper (scientific journal), Last author, Corresponding author, Accepted
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A novel photosensitizer based on hypocrellin B activated by cysteine over-expressed in cancer cells
Fumihisa Ishida, Rikuto Onishi, DAISUKE TAKAHASHI, *Kazunobu Toshima
Organic & Biomolecular Chemistry (Royal Society of Chemistry) 22 7187 - 7193 2024.08
Research paper (scientific journal), Accepted
Papers, etc., Registered in KOARA 【 Display / hide 】
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Toshima, Kazunobu
福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会) 2022
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Development of stimuli activatable photosensitizers and its application to control of cell function
Toshima, Kazunobu
学事振興資金研究成果実績報告書 (慶應義塾大学) 2021
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Toshima, Kazunobu
福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会) 2021
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Development of stimuli activatable photosensitizers and its application to control of cell function.
Toshima, Kazunobu
学事振興資金研究成果実績報告書 (慶應義塾大学) 2020
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Toshima, Kazunobu
福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会) 2020
Reviews, Commentaries, etc. 【 Display / hide 】
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高機能性化粧品素材の創製を指向したマンノシルエリスリトールリピッド（MEL）類縁体の合成と構造活性相関研究
孟継坤, *戸嶋一敦, *高橋大介
オレオサイエンス 24 ( 11 ) 475 - 481 2024.11
Article, review, commentary, editorial, etc. (scientific journal), Last author, Corresponding author
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ホウ素媒介アグリコン転移反応の新展開:反応開発,有用糖質合成,およびケミカルバイオロジーへの応用
*高橋大介, *戸嶋一敦
有機合成化学協会誌 82 ( 9 ) 856 - 866 2024.09
Article, review, commentary, editorial, etc. (scientific journal), Lead author, Corresponding author
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Total Synthesis of Mannosylerythritol Lipids and Structure-Function Relationship Studies
*DAISUKE TAKAHASHI, Kazunobu Toshima
Journal of Oleo Science 73卷 ( 4号 ) 539頁 - 546頁 2024.04
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author
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Photo-Induced Glycosylations Using Organophotoacids: A New Environmentally Benign Carbohydrate Synthesis
*Kazunobu Toshima, DAISUKE TAKAHASHI, Yuka Isozaki
Synlett 35卷 777頁 - 788頁 2023.07
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author
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Boron-mediated aglycon delivery (BMAD) for the stereoselective synthesis of 1,2-cis glycosides
*DAISUKE TAKAHASHI, Kazunobu Toshima
Advances in Carbohydrate Chemistry and Biochemistry 82 79 - 105 2022.11
Article, review, commentary, editorial, etc. (scientific journal), Last author, Corresponding author
Presentations 【 Display / hide 】
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Synthesis of Mannosylerythritol Lipid-Containing LNPs and Their Nucleotide Delivery Activities
〇Misuzu Iha, Itsuki Anzai, Tokiko Watanabe, Kotomi Aso, Yuuya Kasahara, Kazunobu Toshima, Daisuke Takahashi
日本化学会 第105春季年会 (関西大学 千里山キャンパス ) ,
2025.03,Oral presentation (general)
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Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium by Late-stage Boron-mediated Aglycon Delivery
〇Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Maho Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, Masayuki Igarashi, Takeshi Yokoyama, Kazunobu Toshima, Daisuke Takahashi
日本化学会 第105春季年会 (関西大学 千里山キャンパス ) ,
2025.03,Oral presentation (general)
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Development of Microwave-Controlled Boron-Mediated Aglycon Delivery and Total Synthesis of Plant Hormone CLE2
〇Kazuki Senoo, Kazuki Inaba, Ayato Takayanagi, Yuji Wada, Makoto Yasuda, Kazunobu Toshima, Daisuke Takahashi
日本化学会 第105春季年会 (関西大学 千里山キャンパス) ,
2025.03,Oral presentation (general)
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可食性ポリフェノールシナピン酸を活性化剤に用いた環境調和型光グリコシル化反応の開発
◯白石 知佳子, 高橋 大介, 戸嶋 一敦
GlycoTOKYO2024 (創価大学 大教室棟（S棟）) ,
2024.11,Poster presentation, 東京糖鎖研究会
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フコイダン類縁体のデングウイルス感染阻害活性
〇島田 澪, 下岡 誠, 安齋 樹, 渡辺 登喜子, 戸嶋 一敦, 高橋 大介
GlycoTOKYO2024 (創価大学 大教室棟（S棟）) ,
2024.11,Poster presentation, 東京糖鎖研究会
Research Projects of Competitive Funds, etc. 【 Display / hide 】
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天然物を基本骨格とする刺激応答型光感受性分子の創製と次世代型光線力学療法への応用
2022.04-2026.03MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(B), Principal investigator
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機能複合化による生体機能光制御中分子の創製
2016.04-2018.03MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator
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Creation of agents that selectively photo-degrade certain proteins and oligosaccharides and its application to control of cell functions
2014.04-2017.03MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator
Intellectual Property Rights, etc. 【 Display / hide 】
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抗腫瘍活性を有する硫酸化オリゴフコシド類
Date applied： 特願2013-150907 2013.07
Patent, Joint
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ノイラミニダーゼに対する酵素阻害剤
Date applied： 特願2010-022168 2009.02
Patent, Joint
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光増感剤、タンパク質切断剤、タンパク質切断方法、糖分子切断剤、糖分子切断方法、及び光線力学治療剤
Date applied： 特願2007-507210 2006.03
Date issued： 特許第5046029号 2012.07
Patent, Single
Awards 【 Display / hide 】
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義塾賞
2024.11
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SSOCJ Daiichi-Sankyo Award for Medicinal Organic Chemistry 2015
2016.02
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日本化学会学術賞
2015.03
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山下太郎学術研究奨励賞
1996.05
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日本化学会進歩賞
1995.03
Courses Taught 【 Display / hide 】
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SEMINAR IN APPLIED CHEMISTRY
2025
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MOLECULAR LIFE CHEMISTRY 1
2025
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LABORATORIES IN APPLIED CHEMISTRY D
2025
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INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY
2025
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GRADUATE RESEARCH ON FUNDAMENTAL SCIENCE AND TECHNOLOGY 2
2025
Memberships in Academic Societies 【 Display / hide 】
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日本ケミカルバイオロジー学会,
2007.04-Present -
高分子学会,
2004.07-Present -
日本糖質学会,
1991.03-Present -
アメリカ化学会,
1988.06-Present -
有機合成化学協会,
1986.01-Present
Committee Experiences 【 Display / hide 】
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2014.11-Present
幹事, GlycoTokyo
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2014.04-Present
評議員, 日本糖質学会
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2007.04-Present
世話人, 日本ケミカルバイオロジー学会
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2006.04-2008.03
関東支部常任幹事, 有機合成化学協会
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2006.04-2008.03
事業委員会委員, 有機合成化学協会