慶應義塾研究者情報データベース

経歴 【 表示 ／ 非表示 】

経歴 【 表示 ／ 非表示 】

• 2002年11月

  -

  2003年09月

  スイス連邦工科大学, 化学センサーセンター, 上級研究員

• 2005年02月

  -

  2006年01月

  チバ・スペシャルティ・ケミカルズ株式会社（スイス）, 特許情報管理部, 特許弁理士

• 2006年03月

  -

  2007年03月

  慶應義塾大学理工学部, 大学院理工学研究科, 特別研究助教授

• 2007年04月

  -

  2009年03月

  慶應義塾大学理工学部, 応用化学科, 准教授（有期）

• 2009年04月

  -

  2014年03月

  慶應義塾大学理工学部, 応用化学科, 准教授

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研究分野 【 表示 ／ 非表示 】

研究分野 【 表示 ／ 非表示 】

• ナノテク・材料 / 分析化学

研究キーワード 【 表示 ／ 非表示 】

研究キーワード 【 表示 ／ 非表示 】

• バイオセンサ

• 化学センサ

• 機能性色素

• 機能材料

著書 【 表示 ／ 非表示 】

著書 【 表示 ／ 非表示 】

• Applications of Microfluidic Systems in Biology and Medicine

  山田　健太郎、チッテリオ　ダニエル, Springer, Singapore, 2019年04月

  担当範囲: Paper-Based Microfluidics for Point-of-Care Medical Diagnostics / 353-382

• Materials for Chemical Sensing

  チッテリオ　 ダニエル, Springer, 2017年

  担当範囲: (Bio)Chemical Sensors Based on Paper / 29-74

• Design of Polymeric Platforms for Selective Biorecognition

  チッテリオ　 ダニエル, Springer, 2015年

  担当範囲: Inkjet Printing of Biomolecules for Biorecognition / 197-235

論文 【 表示 ／ 非表示 】

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• Development of prediction model for cloud point of thermo-responsive polymers by experiment-oriented materials informatics

  Hayakawa M., Sakano K., Kumada R., Tobita H., Igarashi Y., Citterio D., Oaki Y., Hiruta Y.

  Polymer Chemistry （Polymer Chemistry)  14 （ 19 ） 2383 - 2389 2023年04月

  ISSN  17599954

  　概要を見る

  Thermo-responsive polymers having a lower critical solution temperature (LCST) have attracted attention for biological applications such as drug delivery, diagnosis, and coating materials. In recent years, research on predicting LCST by utilizing machine learning has been conducted. However, since these methods targeted only copolymers combining specific monomer structures, they are not versatile, and multiple trials are still required to obtain new thermo-responsive polymers with the desired LCST. In this study, a prediction model for cloud point temperature (TCP) was built by a combination of materials informatics and chemical insight, named sparse modeling for small data (SpM-S) using a small dataset of polymers collected from the literature as training data. This approach created a model that is interpretable, easy to calculate, and versatile. The prediction accuracy was validated using data from different literature sources and experimental test data. The model was able to predict the TCP of polymers containing monomers not included in the dataset as well as polymers containing monomers included in the dataset. The predictive model has the potential to guide the design of new thermo-responsive polymers, and to contribute to efficient development of thermo-responsive polymers.

  • Access to Document (DOI)

• Evaluation of separation performance for eggshell-based reversed-phase HPLC columns by controlling particle size and application in quantitative therapeutic drug monitoring

  Yoshii T., Nakano K., Okuda T., Citterio D., Hiruta Y.

  Analytical Methods （Analytical Methods)  15 （ 14 ） 1790 - 1796 2023年03月

  ISSN  17599660

  　概要を見る

  Eggshell-based reversed-phase packing materials were applied to an analytical column for high-performance liquid chromatography. Commercially available eggshell powder was classified by a cyclone system to obtain three types of particles with different diameters (arithmetic mean ± standard deviation: 4.3 ± 3.8, 5.6 ± 3.3, and 9.5 ± 5.5 μm). Sedimentation separation removed tiny particles from each sample, resulting in particles with arithmetic means of 6.6 ± 5.5, 7.3 ± 4.5, and 10.2 ± 5.0 μm, respectively. The unclassified particles and three particle types treated with sedimentation separation were subsequently packed into analytical columns (150 mm × 4.6 mm I.D.), and their separation efficiencies were evaluated by comparing their height equivalent to a theoretical plate (HETP). The column without sedimentation separation exhibited the highest HETP, whereas the columns with sedimentation separation showed better separation efficiency and lower back pressure. The column with the best separation efficiency was applied for the separation of 10 alkylbenzenes and 5 steroids, and all peaks were observed with complete separation (peak resolution: RS > 1.5). Finally, the column was used for quantitative analysis of voriconazole, an azole antifungal agent, and imatinib, a first-generation molecularly targeted drug for cancer treatment, in spiked whole blood. Excellent accuracy (99.1-102.8%) and precision (0.6-1.9%) were observed for the spiked drugs and long-term stability (>3000 column volumes of mobile phase flow) indicated good applicability of the developed eggshell-based column as an analytical column for routine analyses of therapeutic drugs in blood.

  • Access to Document (DOI)

• Evaluation of cellophane as platform for colorimetric assays on microfluidic analytical devices

  Shigemori H., Maejima K., Shibata H., Hiruta Y., Citterio D.

  Microchimica Acta （Microchimica Acta)  190 （ 2 ）  2023年02月

  ISSN  00263672

  　概要を見る

  Due to their low cost, simplicity, and pump-free liquid transport properties, colorimetric assays on paper spots and microfluidic paper-based analytical devices (µPADs) are regarded as useful tools for point-of-care testing (POCT). However, for certain types of colorimetric assays, the “non-transparent” and “white” characters of paper can be a disadvantage. In this work, the possibilities of using cellophane as an alternative platform for colorimetric assays have been investigated. Cellophane is a low cost and easy-to-handle transparent film made of regenerated cellulose. Owing to its hydrophilic character, cellophane-based microfluidic channels fabricated through a print–cut–laminate approach enabled pump-free liquid transport into multiple detection areas, similar to µPADs. In addition, the water absorption characteristics of cellophane allowed the stable immobilization of water-soluble colorimetric indicators without any surface modification or additional reagents. The transparency of cellophane provides possibilities for simple background coloring of the substrates, increasing the dynamic signal range for hue-based colorimetric assays, as demonstrated for two model assays targeting H2O2 (46-fold increase) and creatinine (3.6-fold increase). Finally, a turbidity detection-based protein assay was realized on black background cellophane spots. The lowest limits of detection achieved with the cellophane-based devices were calculated as 7 µM for H2O2, 2.7 mg dL−1 for creatinine, and 3.5 mg dL−1 for protein (human serum albumin). Graphical Abstract: [Figure not available: see fulltext.]

  • Access to Document (DOI)

• Fabrication process development and basic evaluation of eggshell-based column packing material for reversed-phase preparative separation

  Yoshii T., Sakama A., Kanamori K., Nakanishi K., Imai H., Citterio D., Hiruta Y.

  Journal of Chromatography A （Journal of Chromatography A)  1688 2023年01月

  ISSN  00219673

  　概要を見る

  Purification of basic drugs in reversed-phase mode is often difficult, mainly due to adsorption of positively charged compounds to the silica gel-based stationary phase. Since this adsorption can be suppressed under alkaline condition, columns with alkali-resistance are required. In addition, compounds with acid-sensitive structures are sometimes degraded during separation on silica gel-based columns which exhibit acidity due to their surface structure. We prepared an alkali-resistant reversed-phase packing material, Eggshell-PMAcO based on eggshells modified with an amphiphilic copolymer, poly(maleic acid-alt-1-octadecene) (PMAcO). The height equivalent to a theoretical plate (HETP) of the Eggshell-PMAcO column was improved by surface treatment with ammonium acetate buffer (900 mM, pH = 3.7), which is an inexpensive reagent, and the retention behavior for hydrophobic compounds was compared to a typical ODS column based on silica gel, resulting in sufficient selectivity of the eggshell-based column for hydrophobic compounds, as indicated by the ratio of retention factors of pentylbenzene and butylbenzene (Eggshell-PMAcO column: 1.55, ODS column: 1.65). Column temperature-dependent retention behavior of naphthalene was investigated in the temperature range from 25 °C to 45 °C, followed by the calculation of thermodynamic parameters. There was little difference in the standard molar enthalpy (Eggshell-PMAcO: −19.6 kJ/mol, ODS: −21.7 kJ/mol). The absolute value of the standard free Gibbs energy for the Eggshell-PMAcO column was much smaller than that of the ODS column (Eggshell-PMAcO: −0.284 kJ/mol, ODS: −13.0 kJ/mol), indicating that the Eggshell-PMAcO column had a weaker retention strength for naphthalene than the ODS column mainly due to the large difference in the standard molar entropy (Eggshell-PMAcO: −64.9 J/mol K, ODS column: −29.2 J/mol K). The retention capacities for imipramine under neutral (water/methanol) and alkaline (0.1% triethylamine water/methanol) conditions were 0.2 mg and 5 mg, respectively, based on injection mass-dependent HETP, retention factor and symmetry factor. Finally, the prepared column was applied to the purification of a building block for nucleic acid drugs. This study demonstrated that reversed-phase columns, which can be fabricated from eggshells and an amphiphilic copolymer in an inexpensive and eco-friendly way, have the ability to purify basic compounds and acid-sensitive compounds.

  • Access to Document (DOI)

• Semi-quantitative microfluidic paper-based analytical device for ionic silica detection

  Ogawa M., Katoh A., Matsubara R., Kondo H., Otsuka M., Sawatsubashi T., Hiruta Y., Citterio D.

  Analytical Sciences （Analytical Sciences)  2023年

  ISSN  09106340

  　概要を見る

  Silicate ions (SiO32−), or ionic silica, are known to cause silica scaling in industrial water applications when excess amounts are present; hence, concentrations must be monitored and kept at a constant low level. Ionic silica is conventionally measured by spectrophotometry in the form of its silicomolybdic complex based on the molybdenum blue reaction, but the operation process is complicated and not suitable for on-site detection. To solve these issues, microfluidic paper-based analytical devices (µPADs) have been gaining attention as portable, low-cost analytical devices suitable for on-site detection. The foldable origami type device described in this work enabled silica detection based on the molybdenum blue reaction, in the range of 50–1000 mg/L, with a practically detectable lowest concentration of 50 mg/L. The device showed selectivity for silicate ions and stability over 21 days when stored at 4 °C. The semi-quantitative analytical performance makes the proposed paper-based device attractive for on-site industrial monitoring. Graphical abstract: [Figure not available: see fulltext.].

  • Access to Document (DOI)

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

• Mgイオンはエネルギー代謝を制御する新規な細胞内情報伝達物質か？

  Daniel, Citterio

  科学研究費補助金研究成果報告書 2018年

• 細胞・臓器イメージング用新規化学センシング分子試薬の開発

  Citterio, Daniel

  科学研究費補助金研究成果報告書 2011年

総説・解説等 【 表示 ／ 非表示 】

総説・解説等 【 表示 ／ 非表示 】

• Editorial: Chemical Sensors for Biomedical Use

  Xie X., Citterio D., Chumbimuni-Torres K., Xue M., Wang X.

  Frontiers in Chemistry (Frontiers in Chemistry)  9 2021年05月

  • Access to Document (DOI)

• Equipment-free Detection of K⁺ on Paper

  Soda Y., Citterio D., Bakker E.

  Chimia (Chimia)  73 ( 11 )  2019年

  ISSN  00094293

  • Access to Document (DOI)

• Paper-based analytical devices

  Citterio D., Kaneta T.

  Analytical Sciences (Analytical Sciences)  34 ( 1 ) 5 - 6 2018年

  ISSN  09106340

  • Access to Document (DOI)

• Toward Practical Application of Paper-Based Microfluidics for Medical Diagnostics: State-of-the-Art and Challenges

  チッテリオ　 ダニエル

  Lab on a Chip (The Royal Society of Chemistry)  17 ( 7 ) 1206 - 1249 2017年02月

  記事・総説・解説・論説等（学術雑誌）, 共著,  ISSN  1473-0197

  • Access to Document (DOI)

• 紙型マイクロ流体デバイス　検査チップの低コスト化と利便化を目指して

  山田　健太郎、チッテリオ　ダニエル

  化学と工業 (日本化学会)  69   120 - 122 2016年

  記事・総説・解説・論説等（その他）, 共著

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研究発表 【 表示 ／ 非表示 】

研究発表 【 表示 ／ 非表示 】

• Paper-Based Analytical Devices (PADs) for On-site Applications

  チッテリオ　ダニエル

  Gordon Research Conference Physics and Chemistry of Microfluidics (Barga) , 

  2023年06月

  , 

  口頭発表（招待・特別）, Gordon Research Conference

• Approaches towards Point-of-Need Applications of Ion-Selective Optodes

  チッテリオ　ダニエル

  Pittcon 2023 (Philadelphia, Pennsylvania) , 

  2023年03月

  , 

  口頭発表（招待・特別）, The Pittsburgh Conference

• Paper-Based Analytical Devices: How Simple Can Analysis Be?

  チッテリオ　ダニエル

  The 4th Materials Research Society of Thailand International Conference (Ubon Ratchathani) , 

  2023年02月

  -

  2023年03月

  , 

  口頭発表（基調）, Materials Research Society of Thailand

• Traffic Light Type Paper-Based Analytical Device for Intuitive and Semi-Quantitative Naked-Eye Signal Readout

  チッテリオ　ダニエル

  Matrafured 2022 International Conference on Chemical Sensors (Visegrad) , 

  2022年06月

  , 

  口頭発表（招待・特別）

• Ionophore-Based Cation-Exchange Optodes for Practical Use: With Paper Platforms to Sample pH-Independent Measurements

  チッテリオ　ダニエル

  Pittcon 2020 (Chicago, Illinois) , 

  2020年03月

  , 

  口頭発表（招待・特別）, The Pittsburgh Conference

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競争的研究費の研究課題 【 表示 ／ 非表示 】

競争的研究費の研究課題 【 表示 ／ 非表示 】

• CRISPR/Casを用いた事前増幅不要で高感度核酸検出可能な紙基板分析デバイス

  2022年04月

  -

  2025年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, チッテリオ ダニエル, 基盤研究(B), 補助金,  研究代表者

• 血中抗体医薬品のPOC分析を可能にするマイクロ流体糸基板センサー

  2018年04月

  -

  2021年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, チッテリオ,　ダニエル, 基盤研究(B), 補助金,  研究代表者

受賞 【 表示 ／ 非表示 】

受賞 【 表示 ／ 非表示 】

• 学術賞

  チッテリオ　ダニエル, 2022年03月, 日本化学会, 化学・生化学センシングのため機能性色素および紙基板分析デバイスの開発

  受賞区分： 国内学会・会議・シンポジウム等の賞

担当授業科目 【 表示 ／ 非表示 】

担当授業科目 【 表示 ／ 非表示 】

• 応用化学輪講

  2024年度

• 機器分析総論

  2024年度

• 応用化学系英語

  2024年度

• ナノスケール科学ジョイントセミナー

  2024年度

• マテリアルデザイン科学ジョイントセミナー

  2024年度

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担当経験のある授業科目 【 表示 ／ 非表示 】

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• 化学・バイオセンサーとセンシングマテリアル

  慶應義塾

  2016年04月

  -

  2017年03月

  , 

  春学期, 講義, 専任

• 応用化学系英語

  慶應義塾

  2016年04月

  -

  2017年03月

  , 

  通年, 講義, 専任

• 基礎化学実験

  慶應義塾

  2016年04月

  -

  2017年03月

  , 

  秋学期, 実習・実験, 専任

• 応用化学実験

  慶應義塾

  2016年04月

  -

  2017年03月

  , 

  春学期, 実習・実験, 専任

• 機能物質概論

  慶應義塾

  2016年04月

  -

  2017年03月

  , 

  春学期, 講義, 専任

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所属学協会 【 表示 ／ 非表示 】

所属学協会 【 表示 ／ 非表示 】

• 日本化学会, 

  2006年04月

  -

  継続中

• 日本分析化学会, 

  2006年04月

  -

  継続中

• 米国化学会, 

  2007年03月

  -

  継続中

• 英国王立化学協会 (RSC) (フェロー), 

  2016年02月

  -

  継続中

委員歴 【 表示 ／ 非表示 】

委員歴 【 表示 ／ 非表示 】

• 2017年04月

  -

  継続中

  Permanent Steering Committee of Europt(r)ode, Europt(r)ode