Papers - Takahashi, Daisuke

Target-Selective Photodegradation of HIV-1 Protease and Inhibition of HIV-1 Replication in Living Cells by Designed Fullerene–sugar Hybrids

Shuho Tanimoto, Satoshi Sakai, Eriko Kudo, Seiji Okada, Shuichi Matsumura, DAISUKE TAKAHASHI, *Kazunobu Toshima

CHEMISTRY AN ASIAN JOURNAL (Wiley‐VCH)  7 ( 5 ) 911 - 914 2012.02

Research paper (scientific journal), Joint Work, Accepted

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Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB

Masatoshi Takeiri, Kana Horie, DAISUKE TAKAHASHI, Mariko Watanabe, Ryoichi Horie, Siro Simizu, *Kazuo Umezawa

ORGANIC & BIOMOLECULAR CHEMISTRY (Royal Society of Chemistry)  10 ( 15 ) 3053 - 3059 2012.02

Research paper (scientific journal), Joint Work, Accepted

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Efficient and Stereoselective Synthesis of the Disaccharide Fragment of Incednine

Takashi Ohtani, Shohei Sakai, Akira Takada, DAISUKE TAKAHASHI, *Kazunobu Toshima

ORGANIC LETTERS (American Chemical Society)  13 ( 22 ) 6126 - 6129 2011.10

Research paper (scientific journal), Joint Work, Accepted

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Degradation of Target Oligosaccharides by Anthraquinone-lectin Hybrids with Light Switching

Yukari Imai, Shingo Hirono, Haruka Matsuba, Yuka Kobayashi, Hirokazu Kawagishi, DAISUKE TAKAHASHI, *Kazunobu Toshima

CHEMISTRY AN ASIAN JOURNAL (Wiley‐VCH)  7 ( 1 ) 97 - 104 2011.10

Research paper (scientific journal), Joint Work, Accepted

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Target-selective Photodegradation of Oligosaccharides by a Fullerene-boronic Acid Hybrid upon Visible Light Irradiation

DAISUKE TAKAHASHI, Shingo Hirono, *Kazunobu Toshima

CHEMICAL COMMUNICATIONS (Royal Society of Chemistry)  47 ( 42 ) 11712 - 11714 2011.09

Research paper (scientific journal), Joint Work, Lead author, Accepted

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Inhibition of Amyloid β Aggregation and Cytotoxicity by Photodegradation Using a Designed Fullerene Derivative

Yasunori Ishida, Tomohiko Fujii, Kotaro Oka, DAISUKE TAKAHASHI, *Kazunobu Toshima

CHEMISTRY AN ASIAN JOURNAL (Wiley‐VCH)  6 ( 9 ) 2312 - 2315 2011.09

Research paper (scientific journal), Joint Work, Accepted

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Molecular Design, Chemical Synthesis, and Biological Evaluation of Agents that Selectively Photo-degrade the Transcription Factor Estrogen Receptor-α

Kana Tsumura, Akane Suzuki, Takeo Tsuzuki, Shuho Tanimoto, Hajime Kaneko, Shuichi Matsumura, Masaya Imoto, Kazuo Umezawa, DAISUKE TAKAHASHI, *Kazunobu Toshima

ORGANIC & BIOMOLECULAR CHEMISTRY (Royal Society of Chemistry)  9 ( 18 ) 6357 - 6366 2011.06

Research paper (scientific journal), Joint Work, Accepted

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Armed-disarmed effect of remote protecting groups on the glycosylation reaction of 2,3-dideoxyglycosyl donors

Satoshi Tomono, Shunichi Kusumi, DAISUKE TAKAHASHI, *Kazunobu Toshima

TETRAHEDRON LETTERS (Elsevier)  52 ( 18 ) 2399 - 2403 2011.03

Research paper (scientific journal), Joint Work, Accepted

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Photodegradation of Target Oligosaccharides by Light-Activated Small Molecules

DAISUKE TAKAHASHI, Shingo Hirono, Chigusa Hayashi, Masayuki Igarashi, Yoshio Nishimura, *Kazunobu Toshima

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (Wiley‐VCH)  49 ( 52 ) 10096 - 10100 2010.11

Research paper (scientific journal), Joint Work, Lead author, Accepted

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Total Synthesis of Incednam, the Aglycon of Incednine

Takashi Ohtani, Shinya Tsukamoto, Hiroshi Kanda, Kensuke Misawa, Yoshifumi Urakawa, Takahiro Fujimaki, Masaya Imoto, Yoshikazu Takahashi, DAISUKE TAKAHASHI, *Kazunobu Toshima

ORGANIC LETTERS (American Chemical Society)  12 ( 21 ) 5068 - 5071 2010.11

Research paper (scientific journal), Joint Work, Accepted

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A Novel Glycosylation of Inactive Glycosyl Donors Using an Ionic Liquid Containing a Protic Acid under Reduced Pressure Conditions

Yasutaka Kuroiwa, Maiko Sekine, Satoshi Tomono, DAISUKE TAKAHASHI, *Kazunobu Toshima

TETRAHEDRON LETTERS (Elsevier)  51 ( 48 ) 6294 - 6297 2010.09

Research paper (scientific journal), Joint Work, Accepted

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従来の糖供与体よりも安定かつ調整容易なメチルグリコシドや1-OH糖が、再利用可能なプロトン酸含有イオン液体中、速やかに活性化されること、さらに、減圧条件下に付すことで、グリコシル化反応が効率的に進行することを示した論文。

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Photo-degradation of Amyloid β by a Designed Fullerene-sugar Hybrid

Yasunori Ishida, Shuho Tanimoto, DAISUKE TAKAHASHI, *Kazunobu Toshima

MED. CHEM. COMMUN. (Royal Society of Chemistry)  1 ( 3 ) 212 - 215 2010.08

Research paper (scientific journal), Joint Work, Accepted

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新規にデザイン・合成したフラーレンと糖とのハイブリッド分子が、アミロイドβの凝集を阻害するだけでなく、人体に害のない長波長紫外光の照射下、アミドロイドβのモノマーおよびオリゴマーを効果的に光分解することを示した論文。

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Effective and Chemoselective Glycosylations Using 2,3-Unsaturated Sugars

Shunichi Kusumi, Kaname Sasaki, Sainan Wang, Tatsuya Watanabe, DAISUKE TAKAHASHI, *Kazunobu Toshima

ORGANIC & BIOMOLECULAR CHEMISTRY (Royal Society of Chemistry)  8 ( 14 ) 3164 - 3178 2010.05

Research paper (scientific journal), Joint Work, Accepted

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生体内におけるリゾチームの糖鎖加水分解反応に着眼し、デザイン・合成した2,3-不飽和糖が2,3-飽和糖および2,3-不飽和-4-ケト糖よりも有意に高い反応性を有することを示し、この反応性の差を利用した化学選択的グリコシル化反応が2,3-ジデオキシ糖鎖の効率的な合成法として有効であることを示した論文。

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Chemoselective Glycosylations Using 2,3-Unsaturated-4-Keto Glycosyl Donors

Shunichi Kusumi, Sainan Wang, Tatsuya Watanabe, Kaname Sasaki, DAISUKE TAKAHASHI, *Kazunobu Toshima

ORGANIC & BIOMOLECULAR CHEMISTRY (Royal Society of Chemistry)  8 ( 5 ) 988 - 990 2010.01

Research paper (scientific journal), Joint Work, Accepted

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デザイン合成した2,3-不飽和-4-ケト糖が対応する2,3-不飽和糖および2,3-飽和糖よりも反応性が低下することを示し、この反応性の差を利用した化学選択的グリコシル化反応が2,3-ジデオキシ糖鎖の効率的な合成法として有効であることを示した論文。

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Hydrolysis of Disaccharides by Metal Species in Neutral Homogeneous Conditions

DAISUKE TAKAHASHI, Sakiko Kobayashi, Kana Tsumura, *Kazunobu Toshima

CHEMISTRY LETTERS (The Chemical Society of Japan)  38 ( 7 ) 728 - 729 2009.06

Research paper (scientific journal), Joint Work, Lead author, Accepted

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糖鎖が中性条件下、金属触媒により、効果的に加水分解されることを初めて示した論文。

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The Synthesis of Carbohydrate Microarrays by S-Alkylation of the Glass-supported 2-Bromoacetamides

DAISUKE TAKAHASHI, Hiroshi Tanaka, Emiko Nakane, *Takashi Takahashi

CHEMISTRY LETTERS (The Chemical Society of Japan)  37 ( 12 ) 1252 - 1253 2008.11

Research paper (scientific journal), Joint Work, Lead author, Accepted

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チオアルキル化反応を利用する糖鎖マイクロアレイの合成と、合成したマイクロアレイ上にて糖鎖－タンパク間相互作用が高感度で観測されることを示した論文。

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Target-selective Photo-degradation of HIV-1 Protease by a Fullerene-sugar Hybrid

Shuho Tanimoto, Satoshi Sakai, Shuichi Matsumura, DAISUKE TAKAHASHI, *Kazunobu Toshima

CHEMICAL COMMUNICATIONS (Royal Society of Chemistry)  0 ( 44 ) 5767 - 5769 2008.10

Research paper (scientific journal), Joint Work, Accepted

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フラーレンがタンパクを光分解することを示し、フラーレンと糖とのハイブリッド分子が、エイズ関連タンパクであるHIV-1プロテアーゼを選択的に光分解することを示した論文。

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鎖状鍵中間体を利用するデオキシオリゴ糖の合成と糖鎖マイクロアレイの開発研究

*高橋 大介

博士学位論文 (東京工業大学大学院理工学研究科)   2006.03

Doctoral thesis, Single Work, Lead author, Last author, Corresponding author

Stereoselective Synthesis of Oligo-α(2,8)-3-deoxy-D-manno-2-octulosonic Acid Derivatives.

Hiroshi Tanaka, DAISUKE TAKAHASHI, *Takashi Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (Wiley‐VCH)  45 ( 5 ) 770 - 773 2005.12

Research paper (scientific journal), Joint Work, Accepted

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KDOの立体選択的グリコシル化反応の開発と、本反応を基盤とするオリゴ-α(2,8)-KDOの立体選択的合成に関する論文。

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Efficient Stereoselective Synthesis of γ-N-Glycosyl Asparagines by N-Glycosylation of Primary Amide Groups

Hiroshi Tanaka, Yuki Iwata, DAISUKE TAKAHASHI, Masaatu Adachi, *Takashi Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (American Chemical Society)  127 ( 6 ) 1630 - 1631 2005.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0002-7863

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一級アミドを糖受容体とするグリコシル化反応が、高収率・高立体選択的に進行することを示し、様々なＮ結合型糖アミノ酸が効率的に合成されることを示した論文。

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