KEIO RESEARCHERS INFORMATION SYSTEM

Profile Summary 【 Display / hide 】

Profile Summary 【 Display / hide 】

• My research interests are glycoscience, cancer cell biology and chemical biology.

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1993.03

  Keio University, Faculty of Science and Engineering, Department of Applied Chemistry

  University, Graduated

• 1998.03

  Keio University, Graduate School, Division of Science and Engineering

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Ph.D., Keio University, Coursework, 1998.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Molecular biology

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Cancer cell biology

• Chemical Biology

• Glycoscience

Books 【 Display / hide 】

Books 【 Display / hide 】

• 実験医学

  宮崎 功、奥村 英夫、清水 史郎、長田 裕之, 2011

  Scope: 79-83

• 化学と工業

  叶 直樹、清水 史郎, 2011

  Scope: 37-39

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Total synthesis of isodaphlongamine H by iridium-catalyzed reductive [3+2] cycloaddition of N-hydroxylactam

  Iwamoto S, Nakano, R, Sasaki K, Kobayashi S, Taira Y, Takei K, Kawakita R, Tokuyama A, Nakamura H, Tomoike M, Kawahara R, Murase A, Simizu S, Chida N, Okamura T & Sato T.

  Angew. Chem. Int. Ed. 64   e202508062 2025

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• Synthesis and evaluation of saponins with all-nitrogenated sugars

  Kage A, Okuyama Y, Kato E, Matagawa T, Kawano S, Simizu S, Chida N, Okamura T & Sato T.

  Synlett 35   427 - 430 2024

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• Identification of C-mannosylation in a receptor tyrosine kinase AXL

  Mori K, Suzuki T, Waki U, Hayashi S, Kadono S, Kawahara R, Takeuchi M, Mizuta H, Dohmae N, Katayama R & Simizu S.

  Glycobiology 34   cwae096 2024

  Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

  • Access to Document (DOI)

• Sensor arrays for electrochemical detection of PCR-amplified genes extracted from cells suspended in environmental waters

  Aoki H, Kawaguchi M, Kumakura Y, Kamo H, Miura K, Hiruta Y, Simizu S & Citterio D.

  Sensors 24   7182 2024

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• Stereodivergent synthesis of 2-oxo-oligopyrrolidines by iterative coupling strategy

  Soda Y, Tatsumi K, Forner M, Sato S, Shibuya K, Matagawa T, Simizu S, Chida N, Okamura T & Sato T.

  Org. Biomol. Chem. 22   3230 - 3236 2024

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Role of C-mannosylation for zebrafish phenotypes

  Simizu, Siro

  福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会)  2023

• Identification of novel enzymes for C-mannosylation and analysis of its substrate proteins

  Simizu, Sirō

  科学研究費補助金研究成果報告書 2020

• Development of novel drug for bone-related diseases using Pirin inhibitors

  Simizu, Siro

  科学研究費補助金研究成果報告書 2014

• Analysis of intracellular logistics by chemical biology

  Shimizu, Shiro

  科学研究費補助金研究成果報告書 2012

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Remembering Professor Kazuo Umezawa (6 December 1946– 12 January 2024)

  Imoto M, Lin Y & Simizu S

  J. Antibiot. 78   336 - 338 2025

  Rapid communication, short report, research note, etc. (scientific journal), Joint Work, Last author

  • Access to Document (DOI)

• Vasculogenic mimicry: A dynamic event of malignancy

  Simizu S

  Biochim. Biophys. Acta (Gen. Subj.) 1866   130084 2022

  Rapid communication, short report, research note, etc. (scientific journal), Single Work, Lead author, Last author, Corresponding author

  • Access to Document (DOI)

• Total synthesis of natural products using intramolecular Nozaki–Hiyama–Takai–Kishi reactions

  Takao K, Ogura A, Yoshida K & Simizu S.

  Synlett 31   421 - 433 2020

  Rapid communication, short report, research note, etc. (scientific journal), Joint Work, Last author

  • Access to Document (DOI)

• Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models

  Umezawa K, Kojima I, Simizu S, Lin Y, Fukaksu H, Koide N, Nakade Y & Yonesa M.

  Human Cell 31   95 - 101 2018

  Rapid communication, short report, research note, etc. (scientific journal), Joint Work

  • Access to Document (DOI)

• C-mannosylation; previous studies and future research perspectives

  Niwa Y & Simizu S.

  Trends Glycosci. Glycotechnol. 30   E231 - E238 2018

  Rapid communication, short report, research note, etc. (scientific journal), Joint Work, Last author, Corresponding author

  • Access to Document (DOI)

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 新規がん分子標的の提唱を目指すケミカルバイオロジー研究

  清水 史郎

  日本ケミカルバイオロジー学会・産学連携委員会「ケミカルバイオロジーの技術革新」・研究会 (大阪) , 

  2025.03

  , 

  Oral presentation (invited, special)

• Angulin-1/LSR is a novel isoform-dependent negative regulator of vasculogenic mimicry by breast cancer cells

  Yuma Yoshioka, Chisato Nosaka, Tomokazu Ohishi, Daisuke Tatsuda, Minami Nakajima, Manabu Kawada, Siro Simizu

  The 28th JFCR-ISCC (International Symposium on Cancer Chemotherapy) (東京) , 

  2024.12

  , 

  Poster presentation

• ゼブラフィッシュにおけるC型糖転移酵素DPY19L1と脊椎形成の関係

  宇佐美 朋子、浅川 和秀、鈴木 健裕、加茂 広貴、堂前 直、川上 浩一、清水 史郎

  GlycoTOKYO2024 (八王子) , 

  2024.11

  , 

  Poster presentation

• カタユウレイボヤDPY19L1のC-mannosylation機能評価

  古島 光、小暮 悠暉、小林 峰人、鈴木 健裕、川原 遼太、堂前 直、堀田 耕司、清水 史郎

  GlycoTOKYO2024 (八王子) , 

  2024.11

  , 

  Poster presentation

• ADAMTS1におけるC-mannosylationの解析

  小林 峰人、 鈴木 健裕、 川原 遼太、 堂前 直、 清水 史郎

  GlycoTOKYO2024 (八王子) , 

  2024.11

  , 

  Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Role of C-mannosylation in zebrafish and development of inhibitors for C-mannosylation

  2024.04

  -

  2027.03

  基盤研究(C), Principal investigator

• 新たなC型糖修飾責任酵素の同定と基質タンパク質の解析

  2018.04

  -

  2021.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 日本がん転移学会　研究奨励賞

  SIMIZU Siro, 2012.07, 日本がん転移学会, ケミカルバイオロジーによる転移関連分子の理解と制御

  Type of Award： Award from Japanese society, conference, symposium, etc.

• B.B.B.論文賞

  MIYAZAKI Isao, SIMIZU Siro, ICHIMIYA Harumi, KAWATANI Makoto, OSADA Hiroyuki, 2009.03, 日本農芸化学会, Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 日本癌学会奨励賞

  SIMIZU Siro, 2004.10, 日本癌学会, 薬剤耐性・転移に関与するがん分子標的の機能解析

  Type of Award： Award from Japanese society, conference, symposium, etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• TOPICS IN CHEMICAL BIOLOGY A

  2025

• SEMINAR IN APPLIED CHEMISTRY

  2025

• MICROBIOLOGY

  2025

• LABORATORIES IN APPLIED CHEMISTRY D

  2025

• INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

  2025

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 東京糖鎖研究会（GlycoTOKYO), 

  2023

  -

  Present

• The Japanese Society of Carbohydrate Research, 

  2015

  -

  Present

• 日本ケミカルバイオロジー学会, 

  2007

  -

  Present

• 日本がん転移学会, 

  2006

  -

  Present

• 日本がん分子標的治療学会, 

  1997

  -

  Present

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2025

  -

  Present

  幹事, 日本ケミカルバイオロジー学会

• 2025

  -

  Present

  男女共同参画委員会委員, 日本がん分子標的治療学会

• 2025

  -

  Present

  理事, 日本がん分子標的治療学会

• 2023

  -

  Present

  評議員, 日本癌学会

• 2023

  -

  Present

  幹事, 東京糖鎖研究会（GlycoTOKYO)

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