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Affiliation
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Faculty of Science and Technology, Department of Applied Chemistry Biochemistry Laboratory ( Yagami )
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Position
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Professor
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Related Websites
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External Links
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Simizu, Siro
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Profile Summary 【 Display / hide 】
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My research interests are glycoscience, cancer cell biology and chemical biology.
Academic Background 【 Display / hide 】
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1993.03
Keio University, Faculty of Science and Engineering, Department of Applied Chemistry
University, Graduated
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1998.03
Keio University, Graduate School, Division of Science and Engineering
Graduate School, Completed, Doctoral course
Books 【 Display / hide 】
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実験医学
宮崎 功、奥村 英夫、清水 史郎、長田 裕之, 2011
Scope: 79-83
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化学と工業
叶 直樹、清水 史郎, 2011
Scope: 37-39
Papers 【 Display / hide 】
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Limited involvement of MMP2, MMP9 and MMP14 in vasculogenic mimicry formation of human tumor cell lines
Yoshida T, Fukuoka E, Kawahara R, Matsubara T & Simizu S.
Biochim. Biophys. Acta (Gen. Subj.) 1870 130954 2026
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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C-mannosyltransferase Dpy19l1l regulates body axis formation via secretion of SCO-spondin in zebrafish
Usami T, Suzuki T, Okubo S, Kamo H, Dohmae N, Fukui H, Asakawa K & Simizu S.
Biochem. Biophys. Res. Commun. 809 153510 2026
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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Total synthesis of keramaphidin B and ingenamine
Kurihara Y, Yagi M, Yoshimura S, Ito K, Shimotani Y, Uematsu M, Noguchi T, Yasufuku H, Okita A, Fukaya K, Oishi T, Kawahara R, Simizu S, Chida N, Okamura T. & Sato T. Total synthesis of keramaphidin B and ingenamine
Synthesis 58 873 - 888 2026
Research paper (scientific journal), Joint Work, Accepted
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Total synthesis of isodaphlongamine H by iridium-catalyzed reductive [3+2] cycloaddition of N-hydroxylactam
Iwamoto S, Nakano, R, Sasaki K, Kobayashi S, Taira Y, Takei K, Kawakita R, Tokuyama A, Nakamura H, Tomoike M, Kawahara R, Murase A, Simizu S, Chida N, Okamura T & Sato T.
Angew. Chem. Int. Ed. 64 e202508062 2025
Research paper (scientific journal), Joint Work, Accepted
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Loss of Angulin-1/LSR promotes vasculogenic mimicry and epithelial–mesenchymal transition in breast cancer
Yoshioka Y, Nosaka C, Ohishi T, Nakajima M, Ishikawa Y, Toyota T, Takemae M, Kubota N, Muramatsu J, Tatsuda D, Kondoh M, Onoe H, Ando J, Kawada M, Ojima H & Simizu S.
J. Biol. Chem. 301 110635 2025
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
Papers, etc., Registered in KOARA 【 Display / hide 】
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Role of C-mannosylation for zebrafish phenotypes
Simizu, Siro
福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会) 2023
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Identification of novel enzymes for C-mannosylation and analysis of its substrate proteins
Simizu, Sirō
科学研究費補助金研究成果報告書 2020
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Development of novel drug for bone-related diseases using Pirin inhibitors
Simizu, Siro
科学研究費補助金研究成果報告書 2014
Reviews, Commentaries, etc. 【 Display / hide 】
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Remembering Professor Kazuo Umezawa (6 December 1946– 12 January 2024)
Imoto M, Lin Y & Simizu S
J. Antibiot. 78 336 - 338 2025
Rapid communication, short report, research note, etc. (scientific journal), Joint Work, Last author
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Vasculogenic mimicry: A dynamic event of malignancy
Simizu S
Biochim. Biophys. Acta (Gen. Subj.) 1866 130084 2022
Rapid communication, short report, research note, etc. (scientific journal), Single Work, Lead author, Last author, Corresponding author
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Total synthesis of natural products using intramolecular Nozaki–Hiyama–Takai–Kishi reactions
Takao K, Ogura A, Yoshida K & Simizu S.
Synlett 31 421 - 433 2020
Rapid communication, short report, research note, etc. (scientific journal), Joint Work, Last author
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Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models
Umezawa K, Kojima I, Simizu S, Lin Y, Fukaksu H, Koide N, Nakade Y & Yonesa M.
Human Cell 31 95 - 101 2018
Rapid communication, short report, research note, etc. (scientific journal), Joint Work
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C-mannosylation; previous studies and future research perspectives
Niwa Y & Simizu S.
Trends Glycosci. Glycotechnol. 30 E231 - E238 2018
Rapid communication, short report, research note, etc. (scientific journal), Joint Work, Last author, Corresponding author
Presentations 【 Display / hide 】
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放線菌由来環状ペプチドphepropeptin Dの抗腫瘍効果と作用機序解明
川原 遼太、岩田 まみ、笹澤 有紀子、荒川 聡子、室井 誠、服部 真一朗、大庭 俊一、大石 智一、遠山 茂広、又川 ともえ、川田 学、満屋 裕明、 五十嵐 雅之、長田 裕之、清水 史郎
[Domestic presentation] 2025年度先端モデル動物支援プラットフォーム 成果発表会 (大津) ,
2026.02,Poster presentation
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Identification of molecular target of phepropeptin D in human cancer cells
Ryota Kawahara, Mami Iwata, Yukiko Sasazawa, Satoko Arakawa, Makoto Muroi, Shin-ichiro Hattori, Shun-ichi Ohba, Tomokazu Ohishi, Shigehiro Tohyama, Tomoe Matagawa, Manabu Kawada, Hiroaki Mitsuya, Masayuki Igarashi, Hiroyuki Osada, Siro Simizu
[International presentation] The 11th Japan-Korea Chemical Biology Symposium (清州) ,
2025.12,Poster presentation
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イソダフロンガミンHの全合成
岩本 青空、仲野 暦、佐々木 啓二、小林 将一朗、平良 侑己、武井 孝也、川北 玲史、徳山 絢子、中村 陽登、友池 真斗、川原 遼太、 村瀬 あかり、清水 史郎、千田 憲孝、岡村 俊孝、佐藤 隆章
[Domestic presentation] 第127回有機合成シンポジウム,
2025.11-2026.11,Oral presentation (general)
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SspoのC-mannosylation欠損によるゼブラフィッシュの体軸異常
大久保 早弥香、宇佐美 朋子、鈴木 健裕、加茂 広貴、堂前 直、川上 浩一、浅川 和秀、清水 史郎
[Domestic presentation] GlycoTOKYO2025 (横浜) ,
2025.10,Poster presentation
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DPY19L1はTSR領域がない基質タンパク質に対してもC-マンノシル化を触媒する
戸川 花菜、清水 勇希、鈴木 健裕、嶋添 凌也、川原 遼太、堂前 直、清水 史郎
[Domestic presentation] GlycoTOKYO2025 (横浜) ,
2025.10,Poster presentation
Research Projects of Competitive Funds, etc. 【 Display / hide 】
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Role of C-mannosylation in zebrafish and development of inhibitors for C-mannosylation
2024.04-2027.03基盤研究(C), Principal investigator
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新たなC型糖修飾責任酵素の同定と基質タンパク質の解析
2018.04-2021.03MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator
Awards 【 Display / hide 】
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日本がん転移学会 研究奨励賞
SIMIZU Siro, 2012.07, 日本がん転移学会, ケミカルバイオロジーによる転移関連分子の理解と制御
Type of Award： Award from Japanese society, conference, symposium, etc.
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B.B.B.論文賞
MIYAZAKI Isao, SIMIZU Siro, ICHIMIYA Harumi, KAWATANI Makoto, OSADA Hiroyuki, 2009.03, 日本農芸化学会, Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II
Type of Award： Award from Japanese society, conference, symposium, etc.
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日本癌学会奨励賞
SIMIZU Siro, 2004.10, 日本癌学会, 薬剤耐性・転移に関与するがん分子標的の機能解析
Type of Award： Award from Japanese society, conference, symposium, etc.
Courses Taught 【 Display / hide 】
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FRONTIER OF CHEMISTRY
2026
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FUNDAMENTALS FOR JITSUGAKU A
2026
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FUNDAMENTALS FOR JITSUGAKU B
2026
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INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY
2026
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MOLECULAR CHEMISTRY AND CHEMICAL BIOLOGY PRACTICAL RESEARCH A
2026
Memberships in Academic Societies 【 Display / hide 】
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東京糖鎖研究会（GlycoTOKYO),
2023-Present -
The Japanese Society of Carbohydrate Research,
2015-Present -
日本ケミカルバイオロジー学会,
2007-Present -
日本がん転移学会,
2006-Present -
日本がん分子標的治療学会,
1997-Present
Committee Experiences 【 Display / hide 】
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2025-Present
幹事, 日本ケミカルバイオロジー学会
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2025-Present
男女共同参画委員会委員, 日本がん分子標的治療学会
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2025-Present
理事, 日本がん分子標的治療学会
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2023-Present
幹事, 東京糖鎖研究会（GlycoTOKYO)
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2023-Present
評議員, 日本癌学会
Click to view the Scopus page. The data was downloaded from Scopus API in April 26, 2026, via http://api.elsevier.com and http://www.scopus.com .