SATO Takaaki

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry （Yagami）

Position

Associate Professor

Related Websites

External Links
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Message from the Faculty Member 【 Display / hide 】

  • 創薬化学を中心に、より有用で機能的な有機分子を求め、合成する化合物の複雑化が急速に進行しています。我々は、化学的な独創性と、社会的に需要の高まった複雑な化合物に適用できる実用性を同時に満たす合成手法を開発し、それを用いて重要な生物活性を有する天然物の全合成を精力的に行っていきます。

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Career 【 Display / hide 】

  • 2003.07
    -
    2003.08

    スイス連邦工科大学　21世紀COE海外研究拠点・研究員

  • 2005.04
    -
    2006.03

    日本学術振興会特別研究員（DC2）

  • 2006.04
    -
    2007.03

    日本学術振興会特別研究員（PD）

  • 2007.04
    -
    2008.03

    カリフォルニア大学アーバイン校・博士研究員

  • 2008.04
    -
    2010.03

    慶應義塾大学　助教（有期）（理工学部応用化学科）

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Academic Background 【 Display / hide 】

  • 2001.03

    Tohoku University, Faculty of Science

    University, Graduated

  • 2006.03

    Tohoku University, Graduate School, Division of Natural Science

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（理学）, Tohoku University, Coursework, 2006.03

    Asymmetric Total Synthesis of (-)-Merrilactone A

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry (Organic Chemistry)

  • Life Science / Bioorganic chemistry (Organic Chemistry)

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Research Keywords 【 Display / hide 】

  • 天然物化学

  • 有機合成化学

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Research Themes 【 Display / hide 】

  • スキップジエン構築法の開発と天然物合成への応用, 

    2010.04
    -
    Present

  • アミド基変換反応の開発, 

    2008.04
    -
    Present

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Books 【 Display / hide 】

  • New Tide of Natural Product Chemistry

    Takaaki Sato, Springer, 2023,  Page： 275‒293

  • ドラマチック有機合成化学 感動の瞬間100

    佐藤隆章, 化学同人, 2023,  Page： 142-143

  • Comprehensive Chirality

    SATOU Takaaki, Elsevier Science, 2012.10

    Scope: 207‒239

  • 天然物合成で活躍した反応 実験のコツとポイント

    井上将行, 佐藤隆章, 化学同人, 2011.11

    Scope: 62-63

  • 天然物全合成の最新動向

    井上将行, 佐藤隆章, 平間正博, シーエムシー出版, 2009.11

    Scope: 3‒17

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Papers 【 Display / hide 】

  • Synthesis and Evaluation of Saponins with All-Nitrogenated Sugars

    Kage A., Okuyama Y., Kato E., Matagawa T., Kawano S., Simizu S., Chida N., Okamura T., Sato T.

    Synlett （Synlett)   2023

    ISSN  09365214

    　View Summary

    Saponins exhibit multiple biological and pharmacological activities, and the sugar moiety of saponins is known to play a crucial role in bioactivity. In this report, we focus on the synthesis and evaluation of saponins with all-nitrogenated sugar (ANS), in which all oxygen atoms are replaced with nitrogen atoms. OSW-1 derivative-, cholesterol-,and diosgenin-ANS glycosides are synthesized by glycosylation with ANS in the presence of TMSOTf. As a result, the OSW-1 mimic, with ANS, exhibits good cytotoxic activity (IC50 = 7.31 ?M) and induces apoptosis.

  • Synthesis of Chiral α, α-Disubstituted Cyclic Nitrones from Secondary Lactams

    Iwamoto S., Tokuyama A., Hiraoka S., Takei K., Matsuzaka K., Matsumoto T., Chida N., Sato T.

    Bulletin of the Chemical Society of Japan （Bulletin of the Chemical Society of Japan)  96 （ 6 ） 529 - 537 2023

    ISSN  00092673

    　View Summary

    Synthesis of chiral α, α-disubstituted cyclic nitrones from secondary lactams is reported. The method consists of two stages involving N-oxidation of the lactams and nucleophilic addition to the lactam carbonyls. The N-oxidation of secondary lactams with mCPBA via imidates provides cyclic nitrones with a chiral stereocenter adjacent to the nitrogen atom. A variety of α, α-disubstituted cyclic nitrones were quickly obtained simply by changing organolithium reagents in the nucleophilic addition to N-OSEM lactams.

  • Copper-Catalyzed Electrophilic Enamidation Using Dioxazolones through Hydrozirconation of Alkynes

    Banjo S., Nakata K., Nakasuji E., Yasui S., Chida N., Sato T.

    Organic Letters （Organic Letters)  24 （ 47 ） 8662 - 8666 2022.12

    ISSN  15237060

    　View Summary

    A copper-catalyzed electrophilic enamidation starting from alkynes is reported. Hydrozirconation of an alkyne with the Schwartz reagent forms a vinyl zirconium intermediate, which directly undergoes a copper-catalyzed electrophilic enamidation with dioxazolones. High functional group tolerance of hydrozirconation enables the use of functionalized alkynes including esters. The developed conditions are successfully applied to syntheses of partial structures found in biologically active natural products.

  • Synthesis of Two Macrocyclic Fragments of Manadomanzamine Alkaloids

    Kurihara Y., Azuma A., Yasufuku H., Takikawa S., Chida N., Sato T.

    Chemistry Letters （Chemistry Letters)  51 （ 12 ） 1146 - 1149 2022.12

    ISSN  03667022

    　View Summary

    The synthesis of two macrocyclic fragments in the manadomanzamine alkaloids based on a strategy using reductive nucleophilic addition to macrolactams is reported. The sequence through the Wittig coupling and macrolactamization gives quick access to both eleven-membered and ten-membered macrolactams. The iridium-catalyzed reductive Strecker reaction of the ten-membered macrolactam takes place via the corresponding unstable imine intermediate.

  • Amphiphilic Copolymer-Modified Eggshell-Based Column Packing Materials for the Preparative Separation of Basic Drugs

    Yoshii T., Mochida M., Kaizu K., Soda Y., Kanamori K., Nakanishi K., Sato T., Imai H., Citterio D., Hiruta Y.

    ACS Applied Polymer Materials （ACS Applied Polymer Materials)  4 （ 10 ） 6949 - 6957 2022.10

    ISSN  2637-6105

    　View Summary

    A way to utilize eggshells is desired because most of the eggshell waste is disposed of in landfills. Despite eggshells having attractive features such as a thermodynamically stable porous crystalline structure, their effective utilization as a functional material has yet to be demonstrated. Herein, we developed an alkali-stable column packing material for reversed-phase preparative high-performance liquid chromatography (HPLC) based on eggshells. Nanocrystals and biopolymers present on eggshell powder were removed by surface treatment with buffered ethylenediaminetetraacetic acid (EDTA) and sodium hypochlorite solutions, resulting in bare calcium carbonate with a uniform porous surface. The obtained particles were modified with poly(maleic acid-alt-1-octadecene) (PMAcO) having hydrophobic alkyl chains and anionic carboxylate groups. The prepared PMAcO-modified eggshell-based material was applied to an HPLC column, and its performance is evaluated. The column succeeded in the separation of alkylbenzenes, steroids, and diastereomers. It was also used for the separation of basic tricyclic antidepressants in an alkaline mobile phase, showing excellent retention capacity and alkali stability. This study demonstrates the potential of eggshell utilization, providing not only a practical stationary phase for HPLC but also a solution for recycling calcium carbonate-based biomineral waste.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Presentations 【 Display / hide 】

  • Amides Enabling Efficient Synthesis of Alkaloids

    Takaaki Sato

    International Symposium for the 80th Anniversary Symposium of the Tohoku Branch Chemical Society, 

    2023.09

  • Unified Total Synthesis of Stemoamide-Type Alkaloids Based on the Amide-Selective Nucleophilic Addition

    Takaaki Sato

    The 11th Singapore International Chemistry Conference, 

    2022.12

  • 複雑分子の合成効率化を目指して

    佐藤隆章

    ヘテロ原子部会2022年度第2回懇話会, 

    2022.12

  • 天然物全合成の効率化について考えてみた

    佐藤隆章

    第55回天然物談話会, 

    2022.06

  • 複雑化合物の超短工程合成を実現するには

    佐藤隆章

    静岡県立大学大学院特別講義, 

    2021.11

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 超短工程化アミド戦略による多環性アルカロイドの合成効率化

    2022.04
    -
    2027.03

    文部科学省・日本学術振興会, 基盤B, Research grant, Principal investigator

  • プロリン・N-メチルアミノ酸選択的なペプチド直接修飾法の開発

    2022.04
    -
    2024.03

    旭硝子財団, 研究奨励, Research grant, Principal investigator

  • ポリケチド医薬品の完全化学合成を目指して

    2021.12
    -
    2023.09

    アステラス病態代謝研究会, 研究助成金, Research grant, Principal investigator

  • アミド基を基盤としたポリケチド合成法の開発

    2021.11
    -
    2022.11

    12. 住友財団, 基礎科学研究助成, Research grant, Principal investigator

  • 反復ブロック合成法による多環性機能分子の創製

    2020

    天野工業技術研究所, 天野工業技術研究所研究助成金, Research grant, Principal investigator

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Awards 【 Display / hide 】

  • Thieme Chemistry Journals Award

    2019

    Type of Award： International academic award (Japan or overseas)

  • BCSJ award

    2017.08, Reductive Approach to Nitrones from N-Siloxyamides and N-Hydroxyamides

  • International Symposium on Pure & Applied Chemistry 2017, Lecture Award

    2017.06, Unified Total Synthesis of Stemoamide-Type Alkaloids

  • Incentive Award in Synthetic Organic Chemistry, Japan

    佐藤隆章, 2017.02, 有機合成化学協会, 反応性制御素子を用いたアミド変換反応の開発と応用

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • BCSJ award

    2015.04, 日本化学会, Total Syntheses of (±)-Gephyrotoxin and (±)-Perhydrogephyrotoxin

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Courses Taught 【 Display / hide 】

  • SEMINAR IN APPLIED CHEMISTRY

    2023

  • ORGANIC CHEMISTRY

    2023

  • MECHANISM IN ORGANIC CHEMISTRY

    2023

  • LABORATORY IN SCIENCE

    2023

  • LABORATORIES IN APPLIED CHEMISTRY B

    2023

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Memberships in Academic Societies 【 Display / hide 】

  • 日本プロセス化学会, 

    2015.03
    -
    Present

  • 日本薬学会, 

    2015.03
    -
    2020.03

  • American Chemical Society, 

    2013
    -
    Present

  • 慶應有機合成化学若手シンポジウム委員会, 

    2012.12
    -
    2022.03

  • 全国高校化学グランプリ委員会, 

    2011
    -
    2012

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Committee Experiences 【 Display / hide 】

  • 2015.12
    -
    2016.05

    実行委員長, 慶應有機化学若手シンポジウム

  • 2015.03
    -
    Present

    会員, 日本プロセス化学会

  • 2015.03
    -
    2023.03

    プロセス化学会将来計画委員, 日本プロセス化学会

  • 2015.03
    -
    2019.12

    会員, 日本薬学会

  • 2013
    -
    Present

    member, American Chemical Society

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