SATO Takaaki

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry (Yagami)

Position

Associate Professor

E-mail Address

E-mail address

Related Websites

External Links

Message from the Faculty Member 【 Display / hide

  • 創薬化学を中心に、より有用で機能的な有機分子を求め、合成する化合物の複雑化が急速に進行しています。我々は、化学的な独創性と、社会的に需要の高まった複雑な化合物に適用できる実用性を同時に満たす合成手法を開発し、それを用いて重要な生物活性を有する天然物の全合成を精力的に行っていきます。

Career 【 Display / hide

  • 2003.07
    -
    2003.08

    スイス連邦工科大学 21世紀COE海外研究拠点・研究員

  • 2005.04
    -
    2006.03

    日本学術振興会特別研究員(DC2)

  • 2006.04
    -
    2007.03

    日本学術振興会特別研究員(PD)

  • 2007.04
    -
    2008.03

    カリフォルニア大学アーバイン校・博士研究員

  • 2008.04
    -
    2010.03

    慶應義塾大学 助教(有期)(理工学部応用化学科)

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Academic Background 【 Display / hide

  • 2001.03

    Tohoku University, Faculty of Science

    University, Graduated

  • 2006.03

    Tohoku University, Graduate School, Division of Natural Science

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(理学), Tohoku University, Coursework, 2006.03

    Asymmetric Total Synthesis of (-)-Merrilactone A

 

Research Areas 【 Display / hide

  • Organic chemistry (Organic Chemistry)

Research Keywords 【 Display / hide

  • 天然物化学

  • 有機合成化学

Research Themes 【 Display / hide

  • スキップジエン構築法の開発と天然物合成への応用, 

    2010.04
    -
    Present

  • アミド基変換反応の開発, 

    2008.04
    -
    Present

 

Books 【 Display / hide

  • Comprehensive Chirality

    SATOU Takaaki, Elsevier Science, 2012.10

    Scope: 207‒239

  • 天然物合成で活躍した反応 実験のコツとポイント

    井上将行, 佐藤隆章, 化学同人, 2011.11

    Scope: 62-63

  • 天然物全合成の最新動向

    井上将行, 佐藤隆章, 平間正博, シーエムシー出版, 2009.11

    Scope: 3‒17

Papers 【 Display / hide

  • Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy

    Miura K., Kawano S., Suto T., Sato T., Chida N., Simizu S.

    Bioorganic and Medicinal Chemistry (Bioorganic and Medicinal Chemistry)  34 2021.03

    ISSN  09680896

     View Summary

    Madangamines are marine natural products isolated from Xestospongia ingens, and madangamine A–E with a different D-ring structure have been reported. We have reported that madangamine A has strong anti-proliferative activity against various human cancer cell lines. In this study, to clarify the anti-proliferative activity of madangamine A, we searched for molecular target of the madangamine A in human cells. Treatment with madangamine A increased the levels of LC3-II and p62, autophagy-related proteins, concomitant with growth inhibition. Moreover, madangamine A resulted in lysosome enlargement and increase in lysosomal pH, which are same phenomena observed in chloroquine-treated cells. These results suggest that madangamine A is a novel lysosome inhibitor, and the anti-proliferative activity of madangamine A is due to the inhibition of lysosome function.

  • Seven-Step Synthesis of All-Nitrogenated Sugar Derivatives Using Sequential Overman Rearrangements

    Okuyama Y., Kidena M., Kato E., Kawano S., Ishii K., Maie K., Miura K., Simizu S., Sato T., Chida N.

    Angewandte Chemie - International Edition (Angewandte Chemie - International Edition)  60 ( 10 ) 5193 - 5198 2021.03

    ISSN  14337851

     View Summary

    All-nitrogenated sugars (ANSs), in which all hydroxy groups in a carbohydrate are replaced with amino groups, are anticipated to be privileged structures with useful biological activities. However, ANS synthesis has been challenging due to the difficulty in the installation of multi-amino groups. We report herein the development of a concise synthetic route to peracetylated ANSs in seven steps from commercially available monosaccharides. The key to success is the use of the sequential Overman rearrangement, which enables formal simultaneous substitution of four or five hydroxy groups in monosaccharides with amino groups. A variety of ANSs are available through the same reaction sequence starting from different initial monosaccharides by chirality transfer of secondary alcohols. Transformations of the resulting peracetylated ANSs such as glycosylation and deacetylation are also demonstrated. Biological studies reveal that ANS-modified cholesterol show cytotoxicity against human cancer cell lines, whereas each ANS and cholesterol have no cytotoxicity.

  • Five-Step Total Synthesis of (±)-Aspidospermidine by a Lactam Strategy via an Azomethine Ylide

    Katahara S., Sugiyama Y., Yamane M., Komiya Y., Sato T., Chida N.

    Organic Letters (Organic Letters)  23 ( 8 ) 3058 - 3063 2021

    ISSN  15237060

     View Summary

    A five-step total synthesis of (±)-aspidospermidine (1) based on a lactam strategy is reported. Our synthesis features an iridium-catalyzed reductive Michael addition/[3+2] cycloaddition cascade to give a tricyclic ketone intermediate from a simple lactam via an azomethine ylide. The developed strategy enables easily available lactams to be used as stable surrogates of multisubstituted amines and would be applicable to a unified total synthesis of complex Aspidosperma alkaloids.

  • Unified Total Synthesis of Pentacyclic Stemoamide-type Alkaloids

    Soda Y., Sugiyama Y., Yoritate M., Tajima H., Shibuya K., Ogihara C., Oishi T., Sato T., Chida N.

    Organic Letters (Organic Letters)  22 ( 19 ) 7502 - 7507 2020.10

    ISSN  15237060

     View Summary

    The collective synthesis of pentacyclic stemoamide-type alkaloids is recognized as a daunting task despite high demand for a comprehensive biological profiling of these natural products. In this Letter, we report a unified synthesis of seven pentacyclic alkaloids and two unnatural derivatives. The keys to success are (1) the chemoselective assembly of four five-membered building blocks, (2) the direct oxidation of pyrrolidine natural products to pyrrole derivatives, and (3) the stereodivergent construction of totally E- or Z-substituted butenolides.

  • Copper-Catalyzed Electrophilic Etherification of Arylboronic Esters with Isoxazolidines

    Katahara S., Takahashi T., Nomura K., Uchiyama M., Sato T., Chida N.

    Chemistry - An Asian Journal (Chemistry - An Asian Journal)  15 ( 12 ) 1869 - 1872 2020.06

    ISSN  18614728

     View Summary

    © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A copper-catalyzed electrophilic etherification of arylboronic esters is reported. Isoxazolidines are utilized as easily available and stable [RO]+ surrogates to give 1,3-amino aryl ethers. The O-selective arylation of isoxazolidines takes place without causing competitive N-arylation. In contrast to previously reported anionic conditions, our copper-catalyzed conditions are mild enough to achieve high functional group tolerance. Preliminary mechanistic studies and DFT calculations support that the reaction proceeds via a transmetalation/oxidative addition pathway, followed by a Lewis acid-promoted reductive elimination to induce the crucial O-selectivity.

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • Short-step Total Synthesis of Natural Products

    佐藤隆章

    第4回「生体適合化学の進歩」インタラクティブフォーラム (ABC-InFO), 2021.06, Oral Presentation(guest/special)

  • アミド基への求核付加反応と天然物全合成

    佐藤隆章

    第7回千葉大学キラリティーネットワーク研究会講演会 (千葉大学西千葉キャンパス(千葉県千葉市)) , 2020.01, Oral Presentation(guest/special)

  • Unified Total Synthesis of Stemoamide-Type Alkaloids by Chemoselective Assembly of Five-Membered Building Blocks

    Takaaki Sato

    Nanyang Research Conference on Synthetic Chemistry and Catalysis (Nanyang Technological University, Singapore) , 2020.01, Oral Presentation(guest/special)

  • Development and Application of Nucleophilic Addition to Amides

    Takaaki Sato

    Keio International Symposium on Innovative Synthesis of Complex Molecules (Yokohama (Japan)) , 2019.12, Oral Presentation(guest/special)

  • アミドが拓く有機合成化学

    佐藤隆章

    日本薬学会東北支部主催 第18回化学系若手研究者セミナー (東北大学大学院薬学研究科(宮城県仙台市)) , 2019.09, Oral Presentation(guest/special)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 反復ブロック合成法による多環性機能分子の創製

    2020

    天野工業技術研究所, 天野工業技術研究所研究助成金, 佐藤隆章, Research grant, Principal Investigator

  • 反復ブロック合成法による多環性ステモナ類の迅速合成

    2019
    -
    2020

    加藤記念バイオサイエンス振興財団, 加藤記念バイオサイエンス振興財団 加藤記念研究助成, 佐藤隆章, Research grant, Principal Investigator

  • アミド基を基盤とした1,3-双極子合成法の開発と応用

    2018.04
    -
    2021.03

    Grant-in-Aid for Scientific Research, 佐藤隆章, Research grant, Principal Investigator

  • 反復ブロック合成法による多環性二次代謝産物の迅速合成

    2018
    -
    2019

    日揮・実吉奨学会, 日揮・実吉奨学会研究助成金, 佐藤隆章, Research grant, Principal Investigator

  • 多環性ステモナ類の反復ブロック合成法の開発

    2017.09
    -
    2018.08

    公益財団法人 戸部眞紀財団 研究助成, 佐藤隆章, Research grant, Principal Investigator

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Awards 【 Display / hide

  • Thieme Chemistry Journals Award

    2019

    Type of Award: International Academic Awards

  • BCSJ award

    2017.08, Reductive Approach to Nitrones from N-Siloxyamides and N-Hydroxyamides

  • International Symposium on Pure & Applied Chemistry 2017, Lecture Award

    2017.06, Unified Total Synthesis of Stemoamide-Type Alkaloids

  • Incentive Award in Synthetic Organic Chemistry, Japan

    佐藤隆章, 2017.02, 有機合成化学協会, 反応性制御素子を用いたアミド変換反応の開発と応用

    Type of Award: Awards of National Conference, Council and Symposium

  • BCSJ award

    2015.04, 日本化学会, Total Syntheses of (±)-Gephyrotoxin and (±)-Perhydrogephyrotoxin

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Courses Taught 【 Display / hide

  • ORGANIC CHEMISTRY

    2021

  • MECHANISM IN ORGANIC CHEMISTRY

    2021

  • LABORATORY IN SCIENCE

    2021

  • LABORATORIES IN APPLIED CHEMISTRY B

    2021

  • INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY

    2021

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Memberships in Academic Societies 【 Display / hide

  • 日本プロセス化学会, 

    2015.03
    -
    Present
  • 日本薬学会, 

    2015.03
    -
    2020.03
  • American Chemical Society, 

    2013
    -
    Present
  • 慶應有機合成化学若手シンポジウム委員会, 

    2012.12
    -
    Present
  • 全国高校化学グランプリ委員会, 

    2011
    -
    2012

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Committee Experiences 【 Display / hide

  • 2015.12
    -
    2016.05

    実行委員長, 慶應有機化学若手シンポジウム

  • 2015.03
    -
    Present

    プロセス化学会将来計画委員, 日本プロセス化学会

  • 2015.03
    -
    Present

    会員, 日本プロセス化学会

  • 2015.03
    -
    2019.12

    会員, 日本薬学会

  • 2013
    -
    Present

    member, American Chemical Society

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