KEIO RESEARCHERS INFORMATION SYSTEM

Profile Summary 【 Display / hide 】

Profile Summary 【 Display / hide 】

• Study on physical and chemical characteristics of atmospheric particulate matter (PM2.5) associated with health hazard

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2020.04

  -

  Present

  理工学部応用化学科, 大学教授

• 2015.04

  -

  2020.03

  理工学部応用化学科, 大学准教授

• 2007.10

  -

  2008.09

  University of Wisconson-Madison, USA, Visiting Assistant Professor

• 2007.04

  -

  2015.03

  理工学部応用化学科, 大学専任講師

• 2002.04

  -

  2007.03

  理工学部応用化学科, 大学助手

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1999.04

  -

  2002.03

  Tokyo University of Agriculture and Technology, Graduate School, Division of Agricltural Sciences

  Graduate School, Completed, Doctoral course

• 1997.04

  -

  1999.03

  Tokyo Metropolitan University, Graduate School, Division of Natural Science, Department of Chemistry

  Graduate School, Completed, Master's course

• 1993.04

  -

  1997.03

  Tokyo Metropolitan University, Faculty of Science, Department of Chemistry

  University, Graduated

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Doctor (Agricultural Science), Tokyo University of Agriculture and Technology, Coursework, 2002.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Environmental Science/Agriculture Science / Environmental dynamic analysis (Environmental Dynamic Analysis)

• Nanotechnology/Materials / Green sustainable chemistry and environmental chemistry (Environmental Chemistry)

• Natural Science / Space and planetary sciences (Earth Astrohemistry)

• Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Transport phenomena and unit operations

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• aerosol, PM2.5, fine particulate matter, physical and chemical characteristics, health impacts

Books 【 Display / hide 】

Books 【 Display / hide 】

• 環境化学

  OKUDA TOMOAKI, 日本有機地球化学会, 2014

  Scope: 日本地球化学会（監修）地球・環境有機分子質量分析マニュアル2014，第１部第５章

• Aerosol Pollution in China

  OKUDA TOMOAKI, TANAKA SHIGERU, HE KEBIN, MA YONGLIANG, 京都大学学術出版会、京都, 2007

  Scope: 24-32

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Contribution of Physical and Chemical Properties to Dithiothreitol-Measured Oxidative Potentials of Atmospheric Aerosol Particles at Urban and Rural Sites in Japan

  Kurihara K., Iwata A., Horwitz S.G.M., Ogane K., Sugioka T., Matsuki A., Okuda T.

  Atmosphere （Atmosphere)  13 （ 2 ）  2022.02

  　View Summary

  Dithiothreitol-measured oxidative potential (OPDTT) can chemically quantify the adverse health effects of atmospheric aerosols. Some chemical species are characterized with DTT activities, and the particle diameter and surface area control DTT oxidizability; however, the physical contribution to OPDTT by atmospheric aerosols is controversial. Therefore, we performed field observations and aerosol sampling at urban and rural sites in Japan to investigate the effect of both physical and chemical properties on the variation in OPDTT of atmospheric aerosols. The shifting degree of the representative diameter to the ultrafine range (i.e., the predominance degree of ultrafine parti-cles) was retrieved from the ratio between the lung-deposited surface area and mass concentrations. The chemical components and OPDTT were also elucidated. We discerned strong positive correlations of K, Mn, Pb, NH4+, SO42−, and pyrolyzable organic carbon with OPDTT. Hence, anthropogenic combustion, the iron–steel industry, and secondary organic aerosols were the major emission sources governing OPDTT variations. The increased specific surface area did not lead to the increase in the OPDTT of atmospheric aerosols, despite the existing relevance of the surface area of water-insoluble particles to DTT oxidizability. Overall, the OPDTT of atmospheric aerosols can be estimated by the mass of chemical components related to OPDTT variation, owing to numerous factors control-ling DTT oxidizability (e.g., strong contribution of water-soluble particles). Our findings can be used to estimate OPDTT via several physicochemical parameters without its direct measurement.

  • Access to Document (DOI)

• Characterization of Elemental Composition and Valence State of Cyclone-collected Aerosol Particles Using EDXRF and XAFS at Three Sites in Japan

  Jing W., Saito K., Okamoto T., Saito H., Sugimoto K., Nishita-Hara C., Hara K., Hayashi M., Hasegawa S., Okuda T.

  Asian Journal of Atmospheric Environment （Asian Journal of Atmospheric Environment)  16 （ 1 ）  2022

  ISSN  19766912

  　View Summary

  The valence state and concentration of metallic pollutants are important factors contributing to the health effects of respirable particulate matter (PM); however, they have not been well studied. In this study, coarse and fine powder samples of atmospheric PM were collected using a cyclone system at Kanagawa (KO), Saitama (SA), and Fukuoka (FU) in Japan in 2017. Energy dispersive X-ray fluorescence spectroscopy (EDXRF) was used to measure the concentrations of nine metallic elements (Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, and Pb), and X-ray absorption fine structure (XAFS) spectroscopy was used to analyze the valence states of target elements (Cr, Mn, Fe, Cu, and Zn). The EDXRF results indicated that the average contents of Fe, Ti, and Zn were much higher than those of the other six elements in all samples. The XAFS results showed that the major valence states of the elements were Cr(III), Mn(II), Fe(III), Cu(II), and Zn(II). The percentages of Mn(IV), Fe(II), and Cu(0) were higher in KO and SA samples than in FU samples. Mn(0) and Zn(0) were detected in some samples only, and Cu(I) was not detected in any samples. Correlation analysis, principal component analysis, and cluster analysis were performed on the EDXRF and XAFS data of the target elements. The source identification results showed that the sources of metal contaminants in the samples varied considerably between sampling sites and depended on the industrial structure and geographical location of the sampling area. Our findings on the different valence states of the elements may be important for determining the toxicity of PM at different locations.

  • Access to Document (DOI)

• Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter

  Ishihara N., Okuda T., Hagino H., Oguro A., Tani Y., Okochi H., Tokoro C., Fujii-Kuriyama Y., Itoh K., Vogel C.F.A., Ishihara Y.

  Journal of Toxicological Sciences （Journal of Toxicological Sciences)  47 （ 5 ） 201 - 210 2022

  ISSN  18803989

  　View Summary

  Air pollutants are important factors that contribute to the development and/or exacerbation of allergic inflammation accompanied by asthma, but experimental evidence still needs to be collected. Interleukin 33 (IL-33) is closely involved in the onset and progression of asthma. In this study, we examined the effects of particulate matter (PM) on IL-33 expression in macrophages. PM2.5 collected in Yokohama, Japan by the cyclone device significantly induced IL-33 expression in human THP-1 macrophages, and the induction was clearly suppressed by pretreatment with the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or the Toll-like receptor 4 (TLR4) antagonist TAK-242. PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. PM samples derived from tunnel dust slightly but significantly induced IL-33 expression, while road dust PM did not affect IL-33 expression. The PAH concentration in tunnel dust was higher than that in road dust. Tunnel dust or road dust PM contained less endotoxin than PM2.5 collected in Yokohama. These data suggest that the potency of IL-33 induction could depend on the concentration of PAHs as well as endotoxin in PMs. Caution regarding PAHs and endotoxin levels in air pollutants should be taken to pre-vent IL-33-induced allergic inflammation.

  • Access to Document (DOI)

• Simulation of the transition metal-based cumulative oxidative potential in East Asia and its emission sources in Japan

  Kajino M., Hagino H., Fujitani Y., Morikawa T., Fukui T., Onishi K., Okuda T., Igarashi Y.

  Scientific Reports （Scientific Reports)  11 （ 1 ）  2021.12

  　View Summary

  The aerosol oxidative potential (OP) is considered to better represent the acute health hazards of aerosols than the mass concentration of fine particulate matter (PM2.5). The proposed major contributors to OP are water soluble transition metals and organic compounds, but the relative magnitudes of these compounds to the total OP are not yet fully understood. In this study, as the first step toward the numerical prediction of OP, the cumulative OP (OPtm*) based on the top five key transition metals, namely, Cu, Mn, Fe, V, and Ni, was defined. The solubilities of metals were assumed constant over time and space based on measurements. Then, the feasibility of its prediction was verified by comparing OPtm* values based on simulated metals to that based on observed metals in East Asia. PM2.5 typically consists of primary and secondary species, while OPtm* only represents primary species. This disparity caused differences in the domestic contributions of PM2.5 and OPtm*, especially in large cities in western Japan. The annual mean domestic contributions of PM2.5 were 40%, while those of OPtm* ranged from 50 to 55%. Sector contributions to the OPtm* emissions in Japan were also assessed. The main important sectors were the road brake and iron–steel industry sectors, followed by power plants, road exhaust, and railways.

  • Access to Document (DOI)

• Effects of ambient particulate matter on a reconstructed human corneal epithelium model

  Ko R., Hayashi M., Tanaka M., Okuda T., Nishita-Hara C., Ozaki H., Uchio E.

  Scientific Reports （Scientific Reports)  11 （ 1 ）  2021.12

  　View Summary

  We evaluated the effects of ambient particulate matter (PM) on the corneal epithelium using a reconstructed human corneal epithelium (HCE) model. We collected two PM size fractions [aerodynamic diameter smaller than 2.4 µm: PM0.3–2.4 and larger than 2.4 µm: PM>2.4] and exposed these tissues to PM concentrations of 1, 10, and 100 µg/mL for 24 h. After exposure, cell viability and interleukin (IL) IL-6 and IL-8 levels were determined, and haematoxylin and eosin and immunofluorescence staining of the zonula occludens-1 (ZO-1) were performed on tissue sections. In addition, the effects of a certified reference material of urban aerosols (UA; 100 µg/mL) were also examined as a reference. The viability of cells exposed to 100 μg/mL UA and PM>2.4 decreased to 76.2% ± 7.4 and 75.4% ± 16.1, respectively, whereas PM0.3–2.4 exposure had a limited effect on cell viability. These particles did not increase IL-6 and IL-8 levels significantly even though cell viability was decreased in 100 μg/mL UA and PM>2.4. ZO-1 expression was reduced in a dose-dependent manner in all groups. Reconstructed HCE could be used as an in vitro model to study the effects of environmental PM exposure on ocular surface cell viability and inflammation.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• High-volume collection of aerosols in India and China using the originally developed cyclone sampler and evaluation of their health impacts

  Okuda, Tomoaki

  科学研究費補助金研究成果報告書 2019

• Elucidation of the electrostatic charging state of ambient aerosols and evaluation of its effect on deposition to body tissue

  Okuda, Tomoaki

  科学研究費補助金研究成果報告書 2019

• Evaluation of health impact of transboundary air pollution by an intensive observation of the concentrations of aerosol surface area and chemical constituents

  Okuda, Tomoaki

  学事振興資金研究成果実績報告書 （慶應義塾大学)  2017

• Elucidation of the electrostatic charging state of ambient aerosols

  Okuda, Tomoaki

  科学研究費補助金研究成果報告書 2016

• PM2.5問題の実態 : 一次情報を参照することの重要さ

  Okuda, Tomoaki

  新版 窮理図解 （慶應義塾大学理工学部)   （ 19 ）  2015.07

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 環境大気エアロゾルの帯電状態測定の現状と展望

  奥田 知明

  クリーンテクノロジー 27 ( 4 ) 37 - 40 2017.06

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

• 連載 エアロゾル基礎講座 ―計測― 6. 分級②：慣性運動や遠心力を用いた分級

  奥田知明, 榎原研正, 飯田健次郎

  エアロゾル研究 (日本エアロゾル学会)  32 ( 4 ) 276 - 288 2017.12

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

• 環境大気中PM2.5の比表面積の測定

  奥田知明

  クリーンテクノロジー (日本工業出版(株))  25 ( 6 ) 23 - 26 2015.06

  Article, review, commentary, editorial, etc. (scientific journal), Single Work

• 東アジアにおけるエアロゾルのフィールド観測および分析法の開発

  奥田知明

  大気環境学会誌 (（公社）大気環境学会)  50 ( 1 ) 1 - 8 2015.01

  Article, review, commentary, editorial, etc. (scientific journal), Single Work

• 我が国におけるPM2.5の現状

  OKUDA TOMOAKI

  航空環境研究 18   3 - 9 2014.04

  Article, review, commentary, editorial, etc. (scientific journal), Single Work

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• PM2.5の物理化学特性の解明と曝露実験による生体有害性評価

  奥田知明

  第88回日本衛生学会 (東京工科大学蒲田キャンパス、東京都大田区) , 

  2018.03

  , 

  Oral presentation (invited, special), 日本衛生学会

• Development of measurement techniques of physical and chemical characteristics of atmospheric aerosols related to their adverse health effect

  Okuda, T.

  Frontiers of Atmospheric Aerosol Studies: Toward the Understanding of Their Health and Climatic Effects (Nagoya, Japan) , 

  2018.01

  , 

  Oral presentation (invited, special)

• Numerical simulation of a parallel plate particle separator for measurement of charging state of PM2.5

  Yonemichi, T., Fukagata, K., Fujioka, K., Okuda, T.

  9th JSME-KSME Thermal and Fluids Engineering Conference (Okinawa, Japan) , 

  2017.10

  , 

  Poster presentation, JSME

• PM2.5を集めて測る ～捕集と特性解明の技術～

  奥田知明

  第7回CSJ化学フェスタ (タワーホール船堀、東京都江戸川区) , 

  2017.10

  , 

  Oral presentation (invited, special), 日本化学会

• 黄砂・PM2.5の健康乳幼児の目・鼻・呼吸器症状への影響 - エコチル調査追加調査『黄砂と子どもの健康調査（パート２）』より -

  金谷久美子、亀田貴之、大久保綾乃、森育子、増本年男、黒沢洋一、大西一成、奥田知明、中山健夫

  第58回大気環境学会年会 (兵庫医療大学、兵庫県神戸市) , 

  2017.09

  , 

  Poster presentation, 大気環境学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Evaluation of the influence of charging state of atmospheric aerosol on particle deposition on human body and ground surface

  2020.04

  -

  2024.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

• Multidisciplinary Analysis of Airborne Particle Surface Area as a New Indicator of Adverse Health Effect of PM2.5

  2018.06

  -

  2021.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

• 独自型サイクロン装置により大量捕集されたPM2.5の化学組成と化学形態の簡便迅速非破壊分析法の開発

  2017.11

  -

  2018.10

  （公財）鉄鋼環境基金, 一般研究助成, Commissioned ｒesearch, Principal investigator

• 大流量サイクロン式PM2.5捕集装置のための新規インレットの開発

  2017.07

  -

  2018.03

  Keio University, 慶應義塾先端科学技術研究センター 指定研究プロジェクト, Research grant, Principal investigator

• 新規サイクロン式大流量エアロゾル捕集システムのインドおよび中国への展開

  2017.07

  -

  2018.03

  Keio University, 慶應義塾大学若手研究者育成ものづくり特別事業, Research grant, Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• 微小粒子の捕集装置

  Date applied： 特願2017-132547  2017.07 

  Date announced： 特開2018-023970  2018.02 

  Patent, Joint

• 自動オープンクロマトグラフィー装置

  Date applied：   2007.07 

  Date announced：   2007.09 

  Date issued： 3135990 

  Utility model, Joint

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 2015 Asian Young Aerosol Scientist Award

  Tomoaki OKUDA, 2015.06, The Asian Aerosol Research Assembly, Outstanding contribution to aerosol science and technology in Asia

  Type of Award： International academic award (Japan or overseas)

• Best Paper Award, Japan Society for Atmospheric Environment

  Tomoaki OKUDA, Masanobu SAKAIDE, Ayumi IWATA, Motoi FUJIWARA, 2020.09, Japan Society for Atmospheric Environment, Investigation of the Characteristics of Particulate Matter Suspended in a Subway Station Platform

  Type of Award： Award from Japanese society, conference, symposium, etc.

• ベストポスター賞

  小山 茜、何 雯雯、奥田知明, 2019.09, 公益社団法人大気環境学会, 突発性環境不耐症対策マスクの開発の試み

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 第９回日韓熱流体工学会議 優秀講演表彰

  Yonemichi, T., Fukagata, K., Fujioka, K., Okuda, T., 2017.12, 日本機械学会流体工学部門, Numerical simulation of a parallel plate particle separator for measurement of charging state of PM2.5

• ベストポスター賞

  桐谷美穂、山﨑花菜、鳩谷和希、奥田知明、兼保直樹、吉野彩子、高見昭憲、船戸浩二、井上浩三、西田千春、原圭一郎、林政彦、鵜野伊津志、山本重一, 2017.09, 公益社団法人大気環境学会, 福岡におけるエアロゾル表面積の濃度変動支配要因の検討

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• SEMINAR IN APPLIED CHEMISTRY

  2022

• LABORATORIES IN APPLIED CHEMISTRY C

  2022

• INTRODUCTION OF ENVIRONMENTAL CHEMISTRY

  2022

• INDEPENDENT STUDY ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS

  2022

• GRADUATE RESEARCH ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS 2

  2022

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 自然科学実験（化学）

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Laboratory work/practical work/exercise, Within own ｆaculty

• 大気環境科学

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture

• 化学B

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture

• 環境化学２

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Lecture

• 応用化学実験CD

  Keio University

  2018.04

  -

  2019.03

  , 

  Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• The Chemical Society of Japan, 

  2015.06

  -

  Present

• Japan Association of Aerosol Science and Technology, 

  2006.04

  -

  Present

• The Japan Society for Analytical Chemistry, 

  2004.04

  -

  Present

• 日本大気化学会, 

  2002.04

  -

  Present

• Japan Society for Atmospheric Environment, 

  2002.04

  -

  Present

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2020.09

  -

  Present

  常任理事, 大気環境学会

• 2020.06

  -

  Present

  新型コロナウイルス対策専門家会議委員, 内閣府

• 2019.04

  -

  Present

  環境安全推進委員会委員長, 日本化学会

• 2019.04

  -

  2020.03

  PM2.5対策総合推進委員会委員, 環境省

• 2017.08

  -

  2020.07

  常任理事, 日本エアロゾル学会

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