Asakura, Kouichi

写真a

Affiliation

Faculty of Science and Technology, Department of Applied Chemistry Department of Applied Chemistry, Faculty of Science and Technology, Keio University (Yagami)

Position

Professor

Related Websites

External Links
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Profile Summary 【 Display / hide 】

  • '''''''Analyze, control and design non-equilibrium chemical system aiming at development of useful technology in organic chemical industry.'''''''

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Career 【 Display / hide 】

  • 1990.04
    -
    1999.03

    慶應義塾大学（理工学部） ,助手

  • 1993.04
    -
    1995.03

    工学院大学 ,兼任講師

  • 1996.09
    -
    1997.08

    Wake Forest大学（米国）, 訪問教員

  • 1999.04
    -
    2003.03

    慶應義塾大学（理工学部） ,専任講師

  • 2003.04
    -
    2007.03

    慶應義塾大学（理工学部） ,助教授

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Academic Background 【 Display / hide 】

  • 1985.03

    Keio University, Faculty of Science and Engineering, 応用化学科

    University, Graduated

  • 1987.03

    Keio University, Graduate School, Division of Science and Engineeri, 応用化学専攻

    Graduate School, Completed, Master's course

  • 1990.03

    Keio University, Graduate School, Division of Science and Engineeri, 応用化学専攻

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 工学　, Keio University, 1990.03

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Licenses and Qualifications 【 Display / hide 】

  • 危険物取扱者甲種, 2002.01

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Research Areas 【 Display / hide 】

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry (Industrial Organic Chemistry)

  • Life Science / Bioorganic chemistry (Industrial Organic Chemistry)

  • Nanotechnology/Materials / Fundamental physical chemistry (Industrial Physical Chemistry)

  • Nanotechnology/Materials / Thin film/surface and interfacial physical properties (Surface Physics)

  • Nanotechnology/Materials / Functional solid state chemistry ("Function, Properties and Materials in Chemistry")

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Research Keywords 【 Display / hide 】

  • 化学反応系の制御と設計

  • 化粧品物理化学

  • 散逸構造

  • 自発的ホモキラリティーの発生

  • 非平衡系の自己組織化

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Research Themes 【 Display / hide 】

  • Analyze, control and design non-equilibrium chemical system aiming at development of useful technology in organic chemical industry., 

    　

    　View Summary

    キラリティーを自発的に発現させる化学システム。
    周期的凹凸構造の自己組織化による超撥水及び光学特性に優れた表面の形成。
    自発的フロンタル重合とその光学材料作成への応用

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Proposed Theme of Joint Research 【 Display / hide 】

  • 塗工・塗装技術、サンスクリーン剤のin vitro性能評価

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Books 【 Display / hide 】

  • サンスクリーン剤の紫外線防御能in vitro評価に与える影響の定量的解析ならびに新規評価法の開発, 化粧品の機能創製・処方・素材開発・解析評価技術と美容理論 第17章

    朝倉浩一, 技術教育出版社, 2022.02,  Page： 150-160

  • Synthetic Approaches to Control Self-propelled Motion of Micrometre-sized Oil Droplets in Aqueous Solution, Self-organized Motion: Physicochemical Design based on Nonlinear Dynamics Chap. 5

    Toyota T., Banno T., Asakura K., Royal Society of Chemistry, 2019.11,  Page： 116-138

  • 日焼け止め化粧料の塗布時に発生するヴィスコスフィンガリング現象がもたらす問題, 最新：化粧品開発のための美容理論 第20章

    朝倉　浩一, 技術教育出版, 2018.07,  Page： 198-208

  • Self-Propelled Motion of Micrometer-Sized Oil Droplets in Aqueous Solution of Surfactant, Properties and Uses of Microemulsions Chap.7

    T. Banno, T. Toyota, K. Asakura, IntechOpen, 2017.05,  Page： 139-154

  • 生体模倣技術としての散逸構造の形成, 生物模倣技術と新材料・新製品開発への応用 第8章 第3節

    ASAKURA KOUICHI, 技術情報協会, 2014.07,  Page： 583-590

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Papers 【 Display / hide 】

  • Molecular insights into the motion of oil droplets in aqueous solutions of ester- and amide-containing cationic surfactants

    Ueno K., Ishiwatari Y., Sasaki K., Kojima T., Takai A., Asakura K., Arai N., Banno T.

    Journal of Molecular Liquids 426 2025.05

    ISSN  01677322

    　View Summary

    The study of self-propelled motion in soft matter systems has garnered significant interest owing to its potential applications in microfluidics, soft robotics, and autonomous system design. Understanding the molecular mechanisms underlying motility is crucial for advancing these applications. This study investigates the self-propelled motion of lauronitrile oil droplets in aqueous surfactant solutions, focusing on the impact of different surfactant molecular structures on droplet dynamics. This study compares surfactants with ester and amide linkages, highlighting their critical role in modulating interfacial tension and driving Marangoni convection, a key factor behind droplet movement. Surfactants with ester linkages exhibit a high affinity for lauronitrile and rapidly adsorb at the oil–water interface, generating strong Marangoni flows and driving fast droplet motion. In contrast, amide-containing surfactants exhibit slower adsorption and weaker interactions with lauronitrile, leading to reduced or absent motion. These findings provide new insights into the molecular mechanisms underlying the self-propelled droplet behavior in non-equilibrium systems and contribute to a deeper understanding of self-organizing phenomena.

  • A molecular strategy for creating functional vesicles with balancing structural stability and stimuli-responsiveness

    Sasaki S., Ueno H., Arai N., Asakura K., Banno T.

    Nanoscale 17 ( 11 ) 6863 - 6873 2025.02

    ISSN  20403364

    　View Summary

    Vesicles, closed bilayer structures composed of amphiphiles, have attracted considerable attention as functional materials. Structural stability and stimulus responsiveness are required for next-generation functional vesicles. However, there is a dilemma between these properties because the desired membrane structure varies in terms of structural stability and stimulus sensitivity. Herein, we propose a new approach for the development of giant vesicles (GVs) through the molecular design and synthesis of amphiphiles with or without amide linkages, forming hydrogen bonding. From the 1H NMR analysis and fluorescence spectra of environment-responsive probes, intermolecular hydrogen bonding between the amide linkages in the membrane contributed to the enhanced structural stability of the GVs. Moreover, by adding amphiphiles containing a photoresponsive azobenzene moiety to GVs composed of amphiphiles with or without amide linkages, a distinct mechanism of photoresponsive deformation was observed: the former exhibited large and irreversible deformation, while the latter showed a modest and reversible manner due to the photoisomerisation of azobenzene under ultraviolet and subsequent visible light illumination. This difference was also attributed to the membrane structure affected by intermolecular hydrogen bonding. Based on these results, the finding provides a molecular methodology for developing highly functional vesicles.

  • Programmed Fabrication of Vesicle-Based Prototissue Fibers with Modular Functionalities

    Kojima T., Asakura K., Gobbo P., Banno T.

    Advanced Science  2025

    　View Summary

    Multicellular organisms have hierarchical structures where multiple cells collectively form tissues with complex 3D architectures and exhibit higher-order functions. Inspired by this, to date, multiple protocell models have been assembled to form tissue-like structures termed prototissues. Despite recent advances in this research area, the programmed assembly of protocells into prototissue fibers with emergent functions still represents a significant challenge. The possibility of assembling prototissue fibers will open up a way to a novel type of prototissue subunit capable of hierarchical assembly into unprecedented soft functional materials with tunable architectures, modular and distributed functionalities. Herein, the first method to fabricate freestanding vesicle-based prototissue fibers with controlled lengths and diameters is devised. Importantly, it is also shown that the fibers can be composed of different specialized modules that, for example, can endow the fiber with magnetotaxis capabilities, or that can work synergistically to take an input diffusible chemical signals and transduce it into a readable fluorescent output through a hosted enzyme cascade reaction. Overall, this research addresses an important challenge of prototissue engineering and will find important applications in 3D bio-printing, tissue engineering, and soft robotics as next-generation bioinspired materials.

  • Photoinduced Shape Changes of Giant Vesicles Comprising Phospholipids and Azobenzene-Containing Cationic Amphiphiles

    Noguchi Y., Sasaki S., Liao Y., Matsuo M., Asakura K., Banno T.

    Chemistry - An Asian Journal  2025

    ISSN  18614728

    　View Summary

    For the development of new functional materials for various applications, such as drug or gene delivery and environmental remediation, the relationship between function and morphology has been considered an important aspect for controlling affinity to the targets. However, there are only a few reports on this relationship because the molecular strategy for the precise control of vesicle shape has been restricted. Herein, we report the photocontrol of vesicle shape using azobenzene-containing amphiphilic switches. The addition of the photoswitches to vesicles composed of phospholipids yielded non-spherical vesicles. They exhibited reversible deformation between a non-spherical and spherical shape in response to ultraviolet and visible light illumination, respectively. From the results of the 1H NMR analyses, fluorescence spectra of the environmentally responsive probes, and Π-A isotherm measurements, the reversible photoresponsivity can be attributed to the changes in the vesicular membrane structures caused by migration of the photoswitches between the aqueous phase and membrane through their photoisomerization.

  • Engineering pH-Responsive, Self-Healing Vesicle-Type Artificial Tissues with Higher-Order Cooperative Functionalities

    Kojima T., Noguchi Y., Terasaka K., Asakura K., Banno T.

    Small 20 ( 30 )  2024.07

    ISSN  16136810

    　View Summary

    Multicellular organisms demonstrate a hierarchical organization where multiple cells collectively form tissues, thereby enabling higher-order cooperative functionalities beyond the capabilities of individual cells. Drawing inspiration from this biological organization, assemblies of multiple protocells are developed to create novel functional materials with emergent higher-order cooperative functionalities. This paper presents new artificial tissues derived from multiple vesicles, which serve as protocellular models. These tissues are formed and manipulated through non-covalent interactions triggered by a salt bridge. Exhibiting pH-sensitive reversible formation and destruction under neutral conditions, these artificial vesicle tissues demonstrate three distinct higher-order cooperative functionalities: transportation of large cargoes, photo-induced contractions, and enhanced survivability against external threats. The rapid assembly and disassembly of these artificial tissues in response to pH variations enable controlled mechanical task performance. Additionally, the self-healing property of these artificial tissues indicates robustness against external mechanical damage. The research suggests that these vesicles can detect specific pH environments and spontaneously assemble into artificial tissues with advanced functionalities. This leads to the possibility of developing intelligent materials with high environmental specificity, particularly for applications in soft robotics.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Theory of Turing pattern formation and its experimental realization in the CIMA reaction system in the presence of materials lowering the diffusivity of activators

    Aizawa A., Asakura K.

    Frontiers in Physics 12 2024

    　View Summary

    In 1952, Alan Turing accomplished a pioneering theoretical study to show that the coupling of nonlinear chemical reactions and diffusion leads to the instability of spatially homogeneous states. The activator and inhibitor are synthesized as intermediates of the reaction system in the Turing model. Turing found that spatially periodic stationary concentration patterns are spontaneously generated when the diffusion coefficient of the activator is lower than that of the inhibitor. The first experimental realization of the Turing pattern was achieved in 1990 in a chlorite–iodide–malonic acid (CIMA) reaction system. Iodide and chlorite anions act as the activator and inhibitor of this reaction system, respectively. Although there is no significant difference in the diffusion coefficient of iodide and chlorite anions, the Turing pattern was generated because starch was added to the gel reactor to enhance the color tone. This formed a complex with iodide to inhibit its diffusion to satisfy the condition for the Turing instability. Several examples were found after this finding. We focused on the high affinity of quaternary alkyl ammonium cations to iodide. The CIMA reaction was performed in an open gel reactor by adding a quaternary alkyl ammonium cationic surfactant. In addition, the polymer gel consists of the quaternary alkyl ammonium group as the side chain was utilized for the open gel reactor. The micelles of the surfactants and the polymer gels trapped iodide in their vicinity as a counter anion to lower the effective diffusivity to satisfy the condition for the Turing instability.

  • Special Issue: The 2<sup>nd</sup> World Congress on Oleo Science, WCOS 2022

    Asakura K.

    Journal of Oleo Science 73 ( 4 ) 389 - 392 2024

    ISSN  13458957

  • サンスクリーン剤のSPF測定のための新規なin vitro法の提案

    朝倉浩一, 藤代美有紀, 矢作彰一, 黒田章裕

    フレグランスジャーナル 50 ( 1 ) 19 - 25 2022.01

  • 塗工過程における自発的な空間周期構造の発生とその制御による表面の機能化

    ASAKURA KOUICHI

    塗装工学 48 ( 5 ) 190 - 197 2013.05

    Single Work

  • 表面形成における非平衡系の自己組織化の制御

    ASAKURA KOUICHI

    オレオサイエンス 13 ( 4 ) 171 - 177 2013.04

    Single Work

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Presentations 【 Display / hide 】

  • Far-from-equilibrium dynamic interface spontaneously generated in drying and mixing processes of two miscible solvents

    Kouichi Asakura, Haruka Watanabe, Taisuke Banno, Shoji Takekawa

    2018 AOCS Annual Meeting & Expo (Minneapolis, (USA)) , 

    2018.05
    , 

    Oral presentation (general), AOCS

  • Surface coating technology developed in far-from-equilibrium systems

    Asakura, K.

    Gordon Research Conference “Oscillations & Dynamic Instabilities in Chemical Systems” (Lucca, Italy) , 

    2010.07
    , 

    Oral presentation (general)

  • Preparation of Photonics Polymers by Spontaneous Frontal Polymerization

    K. Asakura, A. Takata, J. Omoto, E. Nihei

    American Chemical Society National Meeting, Symposium on Nonlinear Dynamics in Polymeric Systems, 

    2008.04
    , 

    Oral presentation (invited, special)

  • Emergence of Homochirality in Chemical Systems

    K. Asakura

    NORTIDA Program "Origins of Homochirality", 

    2008.02
    , 

    Oral presentation (invited, special)

  • Spontaneous Generation of Hot and Reacted Region to Form Propagating Front in a Reaction System of Free-radical Polymerization of Methyl Methacrylate

    朝倉 浩一,井雲昭仁，原澤宏和，小山内州一，二瓶栄輔

    American Chemical Society National Meeting, Symposium on Nonlinear Dynamics in Polymeric Systems (Boston, U.S.A.) , 

    2002.08
    , 

    Oral presentation (invited, special)

    　View Summary

    リーラジカル重合の自己促進は反応器のサイズの影響を受け、適切なサイズとすると、フロンタル重合が中心部から周囲へと進行していく形で反応が完了することを報告した。

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 共同研究「Controlling powder alignment to maximize performance of cosmetics based on the concept of “pseudo-HLB”」

    2021.08
    -
    Present

    Joint research, Principal investigator

  • 共同研究「鋼板の接着接合における鋼板と接着剤との界面接着メカニズム解明に関する研究」

    2021.04
    -
    Present

    Joint research, Principal investigator

  • 共同研究「角膜の生体力学的条件下での形状とその変形の解析」

    2019.04
    -
    Present

    Principal investigator

  • 共同研究「Optical properties evaluation by controlling coating film formation of surface treated powder」

    2017.08
    -
    2021.08

    Joint research, Principal investigator

  • 共同研究「サンスクリーン剤のin vitro性能評価における国際標準化法の確立を目指す産学連携研究」

    2017.04
    -
    Present

    Joint research, Principal investigator

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Works 【 Display / hide 】

  • 第６回宇宙環境利用に関する地上研究

    朝倉 浩一

    2002
    -
    2004
    , 

    Other, Single

    　View Details

    「結晶成長フロントにおけるキラル対称性の破れをもたらすキラル自触媒過程の非線形動力学解析」という研究テーマで、（財）日本宇宙フォーラムより慶應義塾大学理工学部への委託研究という形をとるプロジェクトである。朝倉はこれまでの共同研究者らと連絡は取り合いながらも、基本的には単独でこのプロジェクトに取り組み、将来に宇宙ステーション軌道上実験を行なうための、準備研究を行なう。

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 紫外線吸収剤又は赤外線遮断剤含有水性組成物の紫外線防御効果又は赤外線防御効果の測定方法及び測定装置

    Date applied： PCT/JP2017/031362（優先権主張番号：特願2016-174084）  2017.08 

    Date announced： WO2018/047707（各国移行：欧州公開 EP-A1-003511700, 米国公開 US-A1-2019/0285543）  2018.03 

    Date issued： 特許第6842778号  2021.03

    Date registered： 2021.02

    Patent, Joint

  • 回転霧化式静電塗装装置のベルカップ

    Date applied： PCT/JP2013/075465  2013.09 

    Date announced： WO2014/054438（各国移行：米国, メキシコ, タイ, インドネシア, 中国, ブラジル, 欧州, インド, ロシア）  2014.04 

    Date issued： 特許第5830612号  2015.10

    Patent, Joint

  • 化粧料の紫外線防御効果の測定方法、測定装置、及び測定値の表示方法

    Date applied： 特願2010-206174  2010.09 

    Date announced： 特許公開2012-063180  2012.03 

    Date issued： 特許第5825654号  2015.10

    Patent, Joint

  • 高撥水性組成物

    Date applied： 特許出願2007-227523  2006.09 

    Date announced： 特許公開2008-101197  2008.05 

    Date issued： 特許第5466356号 

    Patent, Joint

  • 高撥水性表面の形成方法

    Date applied： 特許出願2006-242821  2006.09 

    Date announced： 特許公開2008-062182  2008.03 

    Date issued： 特許第4877770号 

    Patent, Joint

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Awards 【 Display / hide 】

  • 日本油化学会 工業技術賞

    朝倉浩一, 黒田章裕, 藤代美有紀, 矢作彰一, 2023.03, （公社）日本油化学会, サンスクリーン剤紫外線防御能の既存のin vitro性能評価法の問題点の解明ならびにそれを克服する新規評価法の開発

  • 日本油化学会 進歩賞

    Kouichi Asakura, 2002.03, （社）日本油化学会, 有機基質の劣化防止に対する新規物質及び新規技術の開発に関する研究

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Courses Taught 【 Display / hide 】

  • SEMINAR IN APPLIED CHEMISTRY

    2025

  • NON-LINEAR DYNAMICS IN CHEMICAL SYSTEM

    2025

  • LABORATORIES IN APPLIED CHEMISTRY D

    2025

  • INDEPENDENT STUDY ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS

    2025

  • GRADUATE RESEARCH ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS 2

    2025

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Educational Activities and Special Notes 【 Display / hide 】

  • 大学院科目「Non-linear Dynamics in Chemical Systems」

    2004.04
    -
    Present

    , Device of Educational Contents

    　View Details

    国際特別コースの科目として英語で開講

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Social Activities 【 Display / hide 】

  • 慶應義塾大学理工学部同窓会副会長

    2019.04
    -
    Present

  • 慶應義塾普通部 目路はるか教室

    慶應義塾普通部

    2020.11

  • 日本油化学会オレオサイエンスフェア2nd（慶大日吉キャンパス）実行委員会副委員長

    （公社）日本油化学会（共催：慶應義塾大学理工学部）,  (慶大日吉キャンパス)

    , 
    2015.08

  • 日本油化学会オレオサイエンスフェア（慶大日吉キャンパス）実行委員会副委員長

    （公社）日本油化学会（共催：慶應義塾大学理工学部）,  (慶大日吉キャンパス)

    , 
    2012.08

  • 火災危険性を有するおそれのある物質等に関する調査検討委員会 委員

    総務省 消防庁

    2009.04
    -
    Present
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Media Coverage 【 Display / hide 】

  • サンスクリーン剤評価法 臨床試験同等の予測値、９月受託開始

    化学工業日報社, 化学工業日報, 2021.08

  • コスモステクニカルセンター 慶應大学らと共同で，新たなUV防御効果測定技術を開発

    毎日新聞出版, 週刊エコノミスト, 2019.10

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Memberships in Academic Societies 【 Display / hide 】

  • 日本油化学会, 

    1985.09
    -
    Present

  • 日本塗装技術協会, 

    2011.01
    -
    Present

  • 日本化学会, 

    1987.01
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2019.04
    -
    2021.03

    会長, 日本油化学会

  • 2022.04
    -
    Present

    副会長 代表理事 創立７０周年記念事業実行委員会委員長 , 日本油化学会

  • 2021.04
    -
    2022.03

    創立７０周年記念事業実行委員会 委員長, 日本油化学会

  • 2019.04
    -
    2021.03

    創立７０周年記念事業準備委員会 委員長, 日本油化学会

  • 2019.09
    -
    2021.08

    学術専門委員会 委員長, 日本油化学会

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