Miyata, Shogo

写真a

Affiliation

Faculty of Science and Technology, Department of Mechanical Engineering （Yagami）

Position

Professor

Related Websites

External Links
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Career 【 Display / hide 】

  • 2003.10
    -
    2004.03

    東京大学大学院工学系研究科21世紀COEリサーチアシスタント

  • 2003.10
    -
    2004.03

    東京大学大学院工学系研究科21世紀COEリサーチアシスタント

  • 2004.04
    -
    2005.03

    東京大学大学院工学系研究科助手

  • 2004.04
    -
    2005.03

    東京大学大学院工学系研究科助手

  • 2004.04
    -
    2011.03

    産業技術総合研究所招聘型客員研究員

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Academic Background 【 Display / hide 】

  • 1999.03

    The University of Tokyo, Faculty of Engineering, 機械工学科

    University, Graduated

  • 2001.03

    The University of Tokyo, Graduate School, Division of Engineering, 機械工学専攻

    Graduate School, Completed, Master's course

  • 2004.03

    The University of Tokyo, Graduate School, Division of Engineering, 機械工学専攻

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（工学）, The University of Tokyo, Coursework, 2004.03

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Research Areas 【 Display / hide 】

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Mechanics of materials and materials

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Mechanics of materials and materials

  • Life Science / Biomedical engineering (Biomedical Engineering/Biological Material Studies)

  • Life Science / Biomedical engineering (Biomedical Engineering/Biological Material Studies)

  • Life Science / Biomaterials (Biomedical Engineering/Biological Material Studies)

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Research Keywords 【 Display / hide 】

  • Biomechanics

  • Biomechanics

  • Tissue engineering

  • Tissue engineering

  • Biophysical engineering

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Research Themes 【 Display / hide 】

  • Development of Biocompatible Flexible Electrode using Conductive Polymer, 

    2013.04
    -
    Present

  • Response of human skin fibroblast to stretch in wound healing process using a novel three-dimensional culture model, 

    2012.12
    -
    Present

  • Fundamental study of platelet diagnosis by dielectrophoretic phenomena, 

    2012.04
    -
    2015.03

  • In vitro formation of the neural network using the response of cells to electrical environment, 

    2011.04
    -
    Present

  • Effect of UV/ozone surface modification on proliferation of embryonic stem cells, 

    2011.04
    -
    2014.03

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Proposed Theme of Joint Research 【 Display / hide 】

  • 細胞チップ（皮膚，神経，毛髪組織，など）を用いた対象薬品および物質のスクリーニングテスト

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Funded Research

  • 細胞チップ（皮膚，脂肪，神経）による創薬スクリーニングデバイスの開発

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Funded Research, Cooperative Research

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Books 【 Display / hide 】

  • 技術予測レポート2023（上）健康寿命の延伸を目指す日本の技術編

    株式会社日本能率協会総合研究所, 2013.12

    Scope: 第3章 治療機器・再生医療

  • Tissue Regeneration - From Basic Biology to Clinical Application

    S. Miyata, INTECH, 2012.03

    Scope: pp.473-488

  • Biomaterials in Asia

    S. Miyata, K. Homma, T. Numano, T. Ushida, T. Tateishi, World Scientific Pub., 2009.01

    Scope: pp.482-493

  • 立石科学技術振興財団助成研究成果集

    MIYATA Shogo, 立石科学技術振興財団, 2009

  • 中谷電子計測技術振興財団年報

    MIYATA Shogo, 中谷電子計測技術振興財団, 2008.08

    Scope: pp.67-70

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Papers 【 Display / hide 】

  • Effect of Compressive Stress in Tumor Microenvironment on Malignant Tumor Spheroid Invasion Process

    R Nishi, Y Oda, T Morikura, S Miyata

    International Journal of Molecular Sciences 23 （ 13 ） 7091 2022.06

    Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

  • Efficient Cell Impedance Measurement by Dielectrophoretic Cell Accumulation and Evaluation of Chondrogenic Phenotypes

    N Nakata, Y Ishibashi, S Miyata

    Micromachines 13 (6), 837  2022.05

    Research paper (scientific journal), Last author, Corresponding author, Accepted

  • Influences of Microscopic Imaging Conditions on Accuracy of Cell Morphology Discrimination Using Convolutional Neural Network of Deep Learning

    M Yamamoto, S Miyata

    Micromachines 13 (5), 760 （Micromachines)  13 （ 5 ）  2022.05

    Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

    　View Summary

    Recently, automated cell culture devices have become necessary for cell therapy appli-cations. The maintenance of cell functions is critical for cell expansion. However, there are risks of losing these functions, owing to disturbances in the surrounding environment and culturing procedures. Therefore, there is a need for a non-invasive and highly accurate evaluation method for cell phenotypes. In this study, we focused on an automated discrimination technique using image processing with a deep learning algorithm. This study aimed to clarify the effects of the optical magnification of the microscope and cell size in each image on the discrimination accuracy for cell phenotypes and morphologies. Myoblast cells (C2C12 cell line) were cultured and differentiated into myotubes. Microscopic images of the cultured cells were acquired at magnifications of 40× and 100×. A deep learning architecture was constructed to discriminate between undifferentiated and differentiated cells. The discrimination accuracy exceeded 90% even at a magnification of 40× for well-developed myogenic differentiation. For the cells under immature myogenic differentiation, a high optical magnification of 100× was required to maintain a discrimination accuracy over 90%. The microscopic optical magnification should be adjusted according to the cell differentiation to improve the efficiency of image-based cell discrimination.

  • Purification of pluripotent embryonic stem cells using dielectrophoresis and a flow control system

    T Kiryo, Y Takahashi, S Miyata

    Engineering in life sciences （Engineering in Life Sciences)  22 （ 5 ） 417 - 426 2022.05

    Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted,  ISSN  16180240

    　View Summary

    Pluripotent stem cells (PSCs) such as embryonic stem cells and induced PSCs can differentiate into all somatic cell types such as cardiomyocytes, nerve cells, and chondrocytes. However, PSCs can easily lose their pluripotency if the culture process is disturbed. Therefore, cell sorting methods for purifying PSCs with pluripotency are important for the establishment and expansion of PSCs. In this study, we focused on dielectrophoresis (DEP) to separate cells without fluorescent dyes or magnetic antibodies. The goal of this study was to establish a cell sorting method for the purification of PSCs based on their pluripotency using DEP and a flow control system. The dielectrophoretic properties of mouse embryonic stem cells (mESCs) with and without pluripotency were evaluated in detail, and mESCs exhibited varying frequency dependencies in the DEP response. Based on the variance in DEP properties, mixed cell suspensions of mESCs can be separated according to their pluripotency with an efficacy of approximately 90%.

  • Titanium culture vessel capable of controlling culture temperature for evaluation of cell thermotolerance

    Imashiro C, Ida Y, Miyata S, Komotori J

    Materials Transactions （Zairyo/Journal of the Society of Materials Science, Japan)  63 （ 3 ） 373 - 378 2022.01

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  05145163

    　View Summary

    Surgery, radiation therapy, and chemical therapy have been reported as main treatments for cancer that is one of the worst diseases reported. However, because of high invasiveness on patients, cancer hyperthermia has been studied as non-invasive treatment. Hyperthermia uses a difference of thermal tolerance between normal and cancer cells and gives an affected part thermal stimulation to kill cancer cells selectively. For developing effective conditions of hyperthermia, in vitro study to evaluate the thermal tolerance have been required. However, since existing cell culture vessels cannot control the culture temperature, genuine thermal tolerance of cells cannot be investigated appropriately. To reveal critical temperature proper for hyperthermia, we developed a culture device controlling culture temperature. With the developed device, culture temperature was regulated far more quickly than conventional method with existing vessels, which enable us to study the thermal tolerance of cells appropriately. For the control of culture temperature, the device has a titanium culture substrate where a peltier element adhered. Since a biocompatibility of the device was confirmed, a difference of thermal tolerance between normal and cancer cells was, then, investigated with the developed device by using Normal Human Dermal Fibroblasts and Michigan Cancer Foundation-7 as model cell species. As a result, it was confirmed that cancer cells were more sensitive to thermal stimulation than normal cells, which was qualitatively consistent with previous researches. Thus, we conclude our developed device can be used for investigation of thermal tolerance of each cell specie, which will contribute for the development of cancer hyperthermia.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Effect of Compressive Stress in Tumor Microenvironment on Malignant Tumor Spheroid Invasion Process

    R Nishi, Y Oda, T Morikura, S Miyata

    International Journal of Molecular Sciences 23 ( 13 ) 7091 2022.06

    Last author, Corresponding author

  • Biocompatibility of materials : mechanical compatibility of biomaterials

    Shogo Miyata

    Pharm stage 16 ( 10 ) 53 - 57 2017.01

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • Non-invasive assessment technology for tissue-engineered material

    Shogo Miyata

    Pharm stage (技術情報協会)  17 ( 5 ) 8 - 12 2017

    Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  1346-3918

  • 微粒子ピーニングによる細胞適合表面の創製とその応用

    小茂鳥 潤, 倉科佑太, 村井一恵, 宮田昌悟, 竹村研治郎, 小山尹誉

    砥粒加工学会誌 57 ( 6 ) 349 - 352 2013

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • マウスES 細胞の剥離プロセスが再播種後の多能性維持 に与える影響

    植野馨太, 宮田昌悟, 阿部公揮, 坂本禎志, 栗原 隆

    the 34th Bioengineering Conference 2022 Annual Meeting of BED/JSME, 

    2022.06
    , 

    Poster presentation

  • 機械的振動刺激が皮膚由来細胞の老化現象に与える影響

    石原美優，宮田昌悟

    the 34th Bioengineering Conference 2022 Annual Meeting of BED/JSME, 

    2022.06
    , 

    Poster presentation

  • Effect of Hydrogel Stiffness on Growth and Invasion Process of Tumor Spheroid

    R Nishi, Y Oda, T Morikura, S Miyata

    the 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021), 

    2021.12
    , 

    Poster presentation

  • Effect of Mechanical Stimulation on Migration Mode of Malignant Melanoma

    R Yoshida, K Harada, T Morikura, S Miyata

    the 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021), 

    2021.12
    , 

    Poster presentation

  • Generation of Cell Spheroid Using Hanging Drop Culture Combined with Orbital Shaking

    S Sato, S Miyata

    the 11th Asian-Pacific Conference on Biomechanics (AP Biomech 2021), 

    2021.12
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 癌細胞の初期悪性化・浸潤を左右する4次元力学場の探索と浸潤抑制治療への展開

    2022.04
    -
    2025.03

    日本学術振興会, 科学研究費補助金, 基盤研究B（一般）, Research grant, Principal investigator

  • 細胞配置と力学的刺激の複合効果がもたらす毛髪および皮膚附属器官の完全生体外再生

    2017.04
    -
    2020.03

    Grant-in-Aid for Scientific Research, Research grant, No Setting

  • プラズマ・ラジカル複合反応を用いた生体分子疑似構造を有するヒトiPS培養基材

    2017.04
    -
    2018.03

    文部科学省, 橋渡し研究加速ネットワークプログラム（シーズA）, Research grant, Principal investigator

  • プラズマ・ラジカル複合反応を用いた生体分子疑似構造を有するヒトiPS培養基材

    2016.12
    -
    2017.03

    文部科学省, 橋渡し研究加速ネットワークプログラム（シーズA）, Research grant, Principal investigator

  • 酸素ラジカル表面改質基材を用いたヒトiPS 細胞の完全単独培養システムと再生心筋細胞移植への展開

    2015.09
    -
    2016.03

    文部科学省, 橋渡し研究加速ネットワークプログラム（シーズA）, Research grant, No Setting

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Works 【 Display / hide 】

  • 未来の起源

    MIYATA Shogo

    2013.04
    -
    Present
    , 

    Other, Single

  • ES細胞安定回収　フィーダ細胞分離 誰でも素早く

    S. Miyata

    2012.08
    -
    Present
    , 

    Other, Single

  • 骨や靱帯を再生させる技術って？

    MIYATA Shogo

    2011.07
    -
    Present
    , 

    Other, Single

  • 慶大、不良・良好な細胞傷つけずに分離する方法開発

    S. Miyata

    2011.07
    -
    Present
    , 

    Other, Single

  • 人のカラダは作ることができるか？

    MIYATA Shogo

    2010.08
    -
    Present
    , 

    Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 細胞担持用基材及びその製造方法

    Date applied： PCT/JP2016/000981  2016.02 

    Patent, Joint

  • 細胞担持用基材及びその製造方法

    Date applied： 特願2015-35439  2015.02 

    Patent, Joint

  • 細胞操作装置

    Date applied： 2012-098304  2012.04 

    Patent, Joint

  • METHOD FOR ACCUMULATING CELLS

    Date applied： US-20120064595-A1  2012 

    Patent, Joint

  • 細胞集積法

    Date applied： 2010－204989  2010.09 

    Patent, Joint

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Awards 【 Display / hide 】

  • Outstanding Student Presentation

    森倉峻, 徳岡雄大, 山田貴大, 板井駿, 長友竜帆, 原田慧吾, 三木則尚, 尾上弘晃, 舟橋啓, 宮田昌悟, 2022.01, 日本機械学会バイオエンジニアリング部門, 高速ラベルフリー三次元細胞形状計測に向けた深層学習に基づくシングルショット計算顕微鏡法

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Young Investigator’s Award

    森倉 峻, 宮田 昌悟, 2019.06, 日本生体医工学会, 間欠的圧縮変形刺激がin vitro三次元悪性黒色腫モデルの細胞増殖を伴う浸潤プロセスに与える影響

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Paper Award

    Y. Kurashina, I. H. M. Hashim, K. Takemura, S. Miyata, J. Komotori, 2015.11, ASME, Resonance Vibration and Temperature Modulation Enhances Cell Detachment from Cultivation Substrate

    Type of Award： International academic award (Japan or overseas),  Country： United States

  • 平成23年度日本材料学会 生体・医療材料部門 研究奨励賞

    MIYATA Shogo, 2012.03

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本機械学会バイオエンジニアリング部門瀬口賞

    MIYATA Shogo, 2012.01, 日本機械学会, 再生軟骨および関節軟骨の非侵襲評価技術に関する研究

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • SPECIAL LECTURE SERIES ON MULTIDISCIPLINARY AND DESIGN SCIENCE

    2024

  • PROJECT LABORATORY IN MECHANICAL ENGINEERING

    2024

  • PHYSICS B

    2024

  • INTRODUCTION TO SCIENCE AND TECHNOLOGY

    2024

  • INTRODUCTION TO MATERIALS SCIENCE

    2024

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Courses Previously Taught 【 Display / hide 】

  • 情報処理同実習

    慶應義塾大学理工学部

    2018.04
    -
    2019.03

  • 図形情報処理

    慶應義塾大学理工学部

    2018.04
    -
    2019.03

  • 機械工学実験

    慶應義塾大学理工学部

    2018.04
    -
    2019.03

  • 機械工学創造演習

    慶應義塾大学理工学部

    2018.04
    -
    2019.03

  • 形状情報の表現

    Keio University

    2017.04
    -
    2018.03
    , 

    Autumn Semester, Laboratory work/practical work/exercise

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Memberships in Academic Societies 【 Display / hide 】

  • 日本機械学会, 

    2011.04
    -
    Present

  • 化学工学会, 

    2011.04
    -
    2013.03

  • 日本材料学会, 

    2009.04
    -
    Present

  • 日本バイオレオロジー学会, 

    2007
    -
    Present

  • American Society of Mechanical Engineers (ASME), 

    2005
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2012.04
    -
    2014.03

    運営委員, 日本機械学会 バイオエンジニアリング部門

  • 2011.04
    -
    2014.03

    関東支部代議員, 日本機械学会

  • 2011.04
    -
    2013.03

    編集委員, 化学工学誌

  • 2010.04
    -
    Present

    会計幹事, 日本材料学会　生体・医療材料部門

  • 2009.04
    -
    2010.03

    庶務幹事, 日本材料学会 生体・医療材料部門

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