Miyata, Shogo

写真a

Affiliation

Faculty of Science and Technology, Department of Mechanical Engineering (Yagami)

Position

Associate Professor

E-mail Address

E-mail address

Related Websites

External Links

Career 【 Display / hide

  • 2003.10
    -
    2004.03

    東京大学大学院工学系研究科21世紀COEリサーチアシスタント

  • 2004.04
    -
    2005.03

    東京大学大学院工学系研究科助手

  • 2004.04
    -
    2011.03

    産業技術総合研究所招聘型客員研究員

  • 2005.04
    -
    2007.03

    九州工業大学大学院生命体工学研究科助手

  • 2006.10
    -
    2007.03

    北九州市立大学国際環境工学部非常勤講師

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Academic Background 【 Display / hide

  • 1999.03

    The University of Tokyo, Faculty of Engineering, 機械工学科

    University, Graduated

  • 2001.03

    The University of Tokyo, Graduate School, Division of Engineering, 機械工学専攻

    Graduate School, Completed, Master's course

  • 2004.03

    The University of Tokyo, Graduate School, Division of Engineering, 機械工学専攻

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(工学), The University of Tokyo, Coursework, 2004.03

 

Research Areas 【 Display / hide

  • Biomedical engineering/Biomaterial science and engineering (Biomedical Engineering/Biological Material Studies)

  • Materials/Mechanics of materials

Research Keywords 【 Display / hide

  • Biomechanics

  • Tissue engineering

  • Biophysical engineering

  • On-chip cell screening system

Research Themes 【 Display / hide

  • Development of Biocompatible Flexible Electrode using Conductive Polymer, 

    2013.04
    -
    Present

  • Response of human skin fibroblast to stretch in wound healing process using a novel three-dimensional culture model, 

    2012.12
    -
    Present

  • Fundamental study of platelet diagnosis by dielectrophoretic phenomena, 

    2012.04
    -
    2015.03

  • In vitro formation of the neural network using the response of cells to electrical environment, 

    2011.04
    -
    Present

  • Effect of UV/ozone surface modification on proliferation of embryonic stem cells, 

    2011.04
    -
    2014.03

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Proposed Theme of Joint Research 【 Display / hide

  • 細胞チップ(皮膚,神経,毛髪組織,など)を用いた対象薬品および物質のスクリーニングテスト

    Interested in joint research with industry (including private organizations, etc.),  Desired form: Funded Research

  • 細胞チップ(皮膚,脂肪,神経)による創薬スクリーニングデバイスの開発

    Interested in joint research with industry (including private organizations, etc.),  Desired form: Funded Research, Cooperative Research

 

Books 【 Display / hide

  • 技術予測レポート2023(上)健康寿命の延伸を目指す日本の技術編

    株式会社日本能率協会総合研究所, 2013.12

    Scope: 第3章 治療機器・再生医療

  • Tissue Regeneration - From Basic Biology to Clinical Application

    S. Miyata, INTECH, 2012.03

    Scope: pp.473-488

  • Biomaterials in Asia

    S. Miyata, K. Homma, T. Numano, T. Ushida, T. Tateishi, World Scientific Pub., 2009.01

    Scope: pp.482-493

  • 立石科学技術振興財団助成研究成果集

    MIYATA Shogo, 立石科学技術振興財団, 2009

  • 中谷電子計測技術振興財団年報

    MIYATA Shogo, 中谷電子計測技術振興財団, 2008.08

    Scope: pp.67-70

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Papers 【 Display / hide

  • Effect of mechanical compression on invasion process of malignant melanoma using in vitro three-dimensional cell culture device

    Morikura T., Miyata S.

    Micromachines (Micromachines)  10 ( 10 )  2019.10

     View Summary

    © 2019 by the authors. Malignant melanoma in the plantar surface of the foot is subjected to various mechanical stimuli generated by daily human activity such as walking. Some studies have reported that mechanical compression affects the development and progression of melanoma. However, little is known about how mechanical compression affects the behavior of malignant melanoma cells in a physiological condition due to the complexity of the invasion mechanisms. In this study, we developed an in vitro three-dimensional cell culture device using microporous membrane in order to evaluate the effects of mechanical compression on the invasion process of malignant melanoma. Our results suggest that the invasion of melanoma cells under the compressive stress for 8 h of culture was promoted with the elongation of F-actin filaments compared to control groups, whereas there was no significant difference between both groups at 32 h of culture, with increasing cell death associated with promoting melanin synthesis. The results of this study contribute to the elucidation of the invasion mechanisms of malignant melanoma caused by mechanical stimulation.

  • Evaluation of lipid accumulation using electrical impedance measurement under three-dimensional culture condition

    Zemmyo D., Miyata S.

    Micromachines (Micromachines)  10 ( 7 )  2019.07

     View Summary

    © 2019 by the authors. The degeneration of adipocyte has been reported to cause obesity, metabolic syndrome, and other diseases. To treat these diseases, an effective in vitro evaluation and drug-screening system for adipocyte culture is required. The objective of this study is to establish an in vitro three-dimensional cell culture system to enable the monitoring of lipid accumulation by measuring electrical impedance, and to determine the relationship between the impedance and lipid accumulation of adipocytes cultured three dimensionally. Consequently, pre-adipocytes, 3T3-L1 cells, were cultured and differentiated to the adipocytes in our culture system, and the electrical impedance of the three-dimensional adipocyte culture at a high frequency was related to the lipid accumulation of the adipocytes. In conclusion, the lipid accumulation of adipocytes could be evaluated in real time by monitoring the electrical impedance during in vitro culture.

  • Effect of cyclic stretch on tissue maturation in myoblast-laden hydrogel fibers

    Bansai S., Morikura T., Onoe H., Miyata S.

    Micromachines (Micromachines)  10 ( 6 )  2019.06

     View Summary

    © 2019 by the authors. Engineering of the skeletal muscles has attracted attention for the restoration of damaged muscles from myopathy, injury, and extraction of malignant tumors. Reconstructing a three-dimensional muscle using living cells could be a promising approach. However, the regenerated tissue exhibits a weak construction force due to the insufficient tissue maturation. The purpose of this study is to establish the reconstruction system for the skeletal muscle. We used a cell-laden core-shell hydrogel microfiber as a three-dimensional culture to control the cellular orientation. Moreover, to mature the muscle tissue in the microfiber, we also developed a custom-made culture device for imposing cyclic stretch stimulation using a motorized stage and the fiber-grab system. As a result, the directions of the myotubes were oriented and the mature myotubes could be formed by cyclic stretch stimulation.

  • Shape Deformation Analysis of Single Cell in 3d Tissue under Mechanical Stimuli

    Kasahara K., Kurashina Y., Miura S., Miyata S., Onoe H.

    2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII)     413 - 416 2019.06

    Accepted,  ISSN  9781728120072

     View Summary

    © 2019 IEEE. This paper describes an analytical platform to investigate the cell response against mechanical stimuli in in vitro 3D tissues. The system is capable of live-imaging cells in 3D tissues at a single cell level under mechanical stimuli, which makes this system similar to the in vivo environment and suitable for analysis of maturation mechanism. We succeeded in imaging various shapes of cells in 3D tissue under mechanical stimuli and observed that the stretch-induced deformation was distributed non-uniformly inside cells. We believe that our system could contribute to a further understanding of the tissue maturation mechanism induced by mechanical stimuli, which is highly useful for the development of tissue reconstruction.

  • Feeder-free culture for mouse induced pluripotent stem cells by using UV/ozone surface-modified substrates

    Kimura Y., Kasai K., Miyata S.

    Materials Science and Engineering C (Materials Science and Engineering C)  92   280 - 286 2018.11

    ISSN  09284931

     View Summary

    © 2018 Elsevier B.V. Pluripotent stem cells (PSCs), especially induced PSCs (iPSCs), have great potential for regenerative medicine. Conventionally, PSCs are cultured and expanded efficiently on feeder cell layers or on cell-adhesive matrices. Large-scale iPSC expansion in an undifferentiated state without laborious culturing procedures and high manufacturing costs for the adhesive matrix is urgently required to integrate iPSCs into therapeutic applications. For this, feeder layers or cell-adhesive matrix coating have to be removed from the iPSC culture system. To enable feeder- and matrix coating-free culture conditions, we focused on a UV/ozone surface treatment technique for polystyrene cell culture substrates to improve PSC adhesion and proliferation. In this study, changes in the molecular structure of UV/ozone-modified polystyrene were characterized to optimize the surface chemistry for iPSC. Mouse iPSCs (miPSCs) were cultured on the UV/ozone-modified polystyrene substrates without feeder layers. As a result, large polymeric chains of polystyrene were dissociated into small polymeric chains and oxidized to form ester and carboxylic acid functional groups by the UV/ozone treatment. Moreover, it was suggested that optimal valance of these modified molecules enabled the feeder- and matrix coating-free culture of miPSC with maintaining pluripotency.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Biocompatibility of materials : mechanical compatibility of biomaterials

    Shogo Miyata

    Pharm stage 16 ( 10 ) 53 - 57 2017.01

    Introduction and explanation (scientific journal), Single Work

  • Non-invasive assessment technology for tissue-engineered material

    Shogo Miyata

    Pharm stage 17 ( 5 )  2017

    Introduction and explanation (scientific journal), Single Work

  • 微粒子ピーニングによる細胞適合表面の創製とその応用

    小茂鳥 潤, 倉科佑太, 村井一恵, 宮田昌悟, 竹村研治郎, 小山尹誉

    砥粒加工学会誌 57 ( 6 ) 349 - 352 2013

    Introduction and explanation (scientific journal), Joint Work

Presentations 【 Display / hide

  • Effect of UV/ozone and atmospheric pressure plasma treatment of cell culture substrates on adhesion and proliferation of mouse ESCs

    Hayato Suzuki, Kohei Kasai, Yuka Kimura, Shogo Miyata

    The 17th Congress of the Japanese Society for Regenerative Medicine (横浜) , 2018.03, Poster (general)

  • In vitro invasion model of malignant melanoma and effect of mechanical stress on invasion process

    Takashi Morikura, Shogo Miyata

    JSME 30th Bioengineering Conference (名古屋) , 2017.12, Oral Presentation(general)

  • Effect of platelet rich plasma concentration on chondrogenesis of cartilage progenitor cells and response to compressive deformation stimuli

    Daiki Zenmyo, Yosikiyo Kibe, Shogo Miyata

    The 44th Annual Meeting of the Japanese Society for Clinical Biomechanics (奈良) , 2017.11

  • Reduction of cell-adhesive matrix coating for hiPSC culture using culture substrates treated with UV/ozone surface modification

    Shogo Miyata, Shugo Tohyama, Kohei Kasai, Jun Fujita, Kei-ichi Fukuda

    The 39th Annual Meeting of the Japanese Society for Biomaterials, 2017.11, Poster (general)

  • Evaluation system of adipocyte differentiation under three-dimensional culture condition using electrical impedance measurement

    Daiki Zenmyo, #HShogo Miyata<U/>

    JSME 28th Conference on Frontiers in Bioengineering (徳島) , 2017.10, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 細胞配置と力学的刺激の複合効果がもたらす毛髪および皮膚附属器官の完全生体外再生

    2017.04
    -
    2020.03

    Grant-in-Aid for Scientific Research, Research grant

  • プラズマ・ラジカル複合反応を用いた生体分子疑似構造を有するヒトiPS培養基材

    2017.04
    -
    2018.03

    文部科学省, 橋渡し研究加速ネットワークプログラム(シーズA), Research grant, Principal Investigator

  • プラズマ・ラジカル複合反応を用いた生体分子疑似構造を有するヒトiPS培養基材

    2016.12
    -
    2017.03

    文部科学省, 橋渡し研究加速ネットワークプログラム(シーズA), Research grant, Principal Investigator

  • 酸素ラジカル表面改質基材を用いたヒトiPS 細胞の完全単独培養システムと再生心筋細胞移植への展開

    2015.09
    -
    2016.03

    文部科学省, 橋渡し研究加速ネットワークプログラム(シーズA), Research grant

  • 幹細胞の多殻ビーズ封入技術と完全性体外での毛髪再生への新展開

    2014.04
    -
    2016.03

    Grant-in-Aid for Scientific Research, Research grant, Principal Investigator

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Works 【 Display / hide

  • 未来の起源

    MIYATA Shogo

    2013.04
    -
    Present

    Other, Single

  • ES細胞安定回収 フィーダ細胞分離 誰でも素早く

    S. Miyata

    2012.08
    -
    Present

    Other, Single

  • 骨や靱帯を再生させる技術って?

    MIYATA Shogo

    2011.07
    -
    Present

    Other, Single

  • 慶大、不良・良好な細胞傷つけずに分離する方法開発

    S. Miyata

    2011.07
    -
    Present

    Other, Single

  • 人のカラダは作ることができるか?

    MIYATA Shogo

    2010.08
    -
    Present

    Other, Single

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Intellectual Property Rights, etc. 【 Display / hide

  • 細胞担持用基材及びその製造方法

    Application No.: PCT/JP2016/000981  2016.02 

    Patent, Joint, PCT international application

  • 細胞担持用基材及びその製造方法

    Application No.: 特願2015-35439  2015.02 

    Patent, Joint

Awards 【 Display / hide

  • Best Paper Award

    Y. Kurashina, I. H. M. Hashim, K. Takemura, S. Miyata, J. Komotori, 2015.11, ASME, Resonance Vibration and Temperature Modulation Enhances Cell Detachment from Cultivation Substrate

    Type of Award: International Academic Awards.  Country: United States of America

  • 平成23年度日本材料学会 生体・医療材料部門 研究奨励賞

    MIYATA Shogo, 2012.03

    Type of Award: Awards of National Conference, Council and Symposium

  • 日本機械学会バイオエンジニアリング部門瀬口賞

    MIYATA Shogo, 2012.01, 日本機械学会, 再生軟骨および関節軟骨の非侵襲評価技術に関する研究

    Type of Award: Awards of National Conference, Council and Symposium

  • 2011年日本臨床バイオメカニクス学会学会奨励賞

    MIYATA Shogo, 2011.11, 誘電泳動チップを用いた軟骨細胞の分化・脱分化状態の識別

    Type of Award: Awards of National Conference, Council and Symposium

  • 平成22年度日本材料学会学術奨励賞

    MIYATA Shogo, 2011.05, 磁気共鳴イメージング(MRI)手法を用いた再生医療用材料の非侵襲評価法

    Type of Award: Awards of National Conference, Council and Symposium

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Courses Taught 【 Display / hide

  • TOPICS IN MULTIDISCIPLINARY SCIENCE

    2020

  • PROJECT LABORATORY IN MECHANICAL ENGINEERING

    2020

  • PHYSICS B

    2020

  • INDEPENDENT STUDY ON INTEGRATED DESIGN ENGINEERING

    2020

  • GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 2

    2020

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Courses Previously Taught 【 Display / hide

  • 情報処理同実習

    慶應義塾大学理工学部, 2018

  • 図形情報処理

    慶應義塾大学理工学部, 2018

  • 機械工学実験

    慶應義塾大学理工学部, 2018

  • 機械工学創造演習

    慶應義塾大学理工学部, 2018

  • 形状情報の表現

    Keio University, 2017, Autumn Semester, Major subject, Laboratory work/practical work/exercise

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Memberships in Academic Societies 【 Display / hide

  • 日本機械学会, 

    2011.04
    -
    Present
  • 化学工学会, 

    2011.04
    -
    2013.03
  • 日本材料学会, 

    2009.04
    -
    Present
  • 日本バイオレオロジー学会, 

    2007
    -
    Present
  • American Society of Mechanical Engineers (ASME), 

    2005
    -
    Present

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Committee Experiences 【 Display / hide

  • 2012.04
    -
    2014.03

    運営委員, 日本機械学会 バイオエンジニアリング部門

  • 2011.04
    -
    2014.03

    関東支部代議員, 日本機械学会

  • 2011.04
    -
    2013.03

    編集委員, 化学工学誌

  • 2010.04
    -
    Present

    会計幹事, 日本材料学会 生体・医療材料部門

  • 2009.04
    -
    2010.03

    庶務幹事, 日本材料学会 生体・医療材料部門