研究者詳細 - 三木　則尚

論文 - 三木　則尚

分割表示 185 件中 141 - 160 件目／全件表示 >>

Dynamics of a microflight mechanism with magnetic rotational wings in an alternating magnetic field

Miki N, Shimoyama I

JOURNAL OF MICROELECTROMECHANICAL SYSTEMS （IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC） 11 （ 5 ） 584-591 2002年10月

研究論文（学術雑誌）, 共著, 査読有り, ISSN 1057-7157

微小機構の安定した飛行には，姿勢制御が最も重要となる．本論文は，微小機構のボディ部分に形状磁気異方性をもつ磁性体を成膜し，交流磁場による磁気異方性トルクを利用した姿勢制御を提唱している．交流磁場は回転翼の駆動にも使用される．MEMS製作技術を用いて，微小飛行機構を製作し，交流磁場中において安定した飛行を実現した．また高速度カメラにより飛行を観察し，微小機構の飛行ダイナミクスを解析した．交流磁場により，同時に回転翼の駆動と姿勢制御をおこなうことにより，微小機構の簡素化，軽量化が可能となり，飛行が実現されたと結論した．

交流磁場中で回転するマイクロ磁性体回転翼

三木則尚下山勲

日本電気学会，センサ・マイクロマシン準部門誌 121-E （ 4 ） 221-229 2001年

研究論文（学術雑誌）, 共著, 査読有り

マイクロロボット移動用の回転翼に使用される磁性体は軟磁性体であり，回転中に磁化の大きさ，方向ともに変化する．本論文において，回転中の磁化および磁気トルクの変化を，計算および数ミリサイズのラージスケール磁性体翼による実験から解析した．磁性体の磁気特性とともに，形状磁気異方性が重要な役割を担っていることを明らかにした．また翼長0.9ミリメートルの磁性体回転翼をMEMS (Microelectromechanical Systems) 製作技術を用いて実現した．

Study on micro-flying robots

Miki N, Shimoyama I

ADVANCED ROBOTICS 13 （ 3 ） 245-246 1999年

研究論文（学術雑誌）, 共著, ISSN 0169-1864

Effective Dissolution of a Gaseous Odorant in Liquid Using Gas Flow

Nakane T., Osaki T., Mimura H., Takamori S., Miki N., Takeuchi S.

Advanced Materials Technologies 2024年

Olfactory receptors are known for their high specificity, sensitivity, and nanometer-sized sensing element, making them ideal for in situ odorant sensor applications. However, one of the major limitations of these sensors is the requirement for an aqueous environment to maintain their function, while most odorants are poorly soluble in water. To address this issue, a microfluidic device consisting of a gas-flow channel and a microwell is proposed that enables the effective dissolution of a gaseous odorant in an aqueous solution. Computational simulations are used to design the gas-flow channel and the well, and the performance of the odorant dissolution is verified using the fabricated device. This study considers that convection in water induced by the gas flow enhances the dissolution of a gaseous odorant. The feasibility of the device is demonstrated for on-site detection of a gaseous odorant. This approach facilitates the development of highly responsive and portable sensors utilizing olfactory receptors, offering a promising solution to the limitations of current odorant sensors.

Access to Document (DOI)

Bubble-Assisted Re-Formation of Individual Lipid Bilayers in Arrayed Device

Hashimoto I., Osaki T., Mimura H., Takamori S., Miki N., Takeuchi S.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) （Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)） 2023-January 279 - 280 2023年

ISSN 10846999

This paper describes a method capable of individual and selective re-formation of ruptured BLMs (bilayer lipid membranes) by using air bubbles in arrayed devices. BLMs play an important role in membrane protein studies, biosensor applications, and drug screening. In such applications, data throughput is a key issue, but BLMs are easily ruptured by physical/electrical disturbance, which makes it difficult to operate a large BLM array. In this work, we propose a bubble-assisted BLM re-formation method: An aqueous phase is divided by a small air bubble covered with a lipid monolayer. After the bubble departed, the divided aqueous phases are brought into contact with the lipid monolayer, resulting in formation of BLM. This method enables selective BLM re-formation in a multichannel device. To verify individual and selective BLM re-formation using this method, we developed a 4ch bubble-assisted device and demonstrated repetitive BLM re-formation.

Access to Document (DOI)

Hand-Driven Device for Preparation of Linearly Aligned Hydrogel Sheets

Kato A., Oda H., Takamori S., Mimura H., Osaki T., Miki N., Takeuchi S.

ISSN 10846999

In this paper, we present a three-layered device for preparation of heterologous core layers linearly aligned in a hydrogel sheet by a simple four-step process without using pumps. Recently, cell-based sensors have been developed for detection of odorant molecules owing to the sensitivity and selectivity of olfactory receptors to chemical substances. To detect various odorant molecules with these sensors, it is necessary to array multiple types of sensor cells expressing different olfactory receptors. We therefore propose a sheet-shaped sensor chip for a sensor-cell array. Previously, hydrogel sheets with heterogeneous cell patterns were produced using microfluidic devices with syringe pump systems, causing loss of both sample volumes and time for settings. Here, we develop a device that enables preparation of hydrogel sheets with a small amount of samples and with a single manual pipette.

Access to Document (DOI)

Gas-Flow Device for Effective Dissolution of Gas-Phase Odorants Utilized for Biohybrid Sensors

Nakane T., Osaki T., Mimura H., Takamori S., Miki N., Takeuchi S.

ISSN 10846999

This study describes a gas-flow device that enhances the solubility of gas-phase odorants into aqueous solution for cell-based sensors. Cell-based sensors using olfactory receptors have attracted attention because of their high sensitivity and selectivity. However, most of previous studies used liquid-phase odorants as a target sample due to their low solubility of gas-phase odorants even though the applications expect the gas-phase sensing. Therefore, we focus on gas-phase odorant detection using the gas-flow device. Here, we clarify the impact of the velocity of convection inside the solution to enhancement of the solubility, based on computational simulation. Moreover, we experimentally verify efficiency of odorant dissolution in two types of devices, compared with the negative control using a sample odorant.

Access to Document (DOI)

Cartridge Device Capable of Spontaneous Solution Exchange for Sensor Cell Production

Tanaka A., Takamori S., Mimura H., Osaki T., Miki N., Takeuchi S.

IEEE Symposium on Mass Storage Systems and Technologies （IEEE Symposium on Mass Storage Systems and Technologies） 2022-January 166 - 167 2022年

ISSN 21601968

This paper reports a cartridge-type device to produce sensor cells with spontaneous solution exchange. Our group has developed a cell-based odorant sensor expressed olfactory receptors. These sensor cells presented excellent sensitivity and specificity, which would be useful for a wide range of sensor applications. However, production of such sensor cells requires multiple times of aseptic solution exchanges. In this work, we develop a cartridge-type cell culture device that utilizes capillary force for spontaneous solution exchange without pumps or tubes. When the cartridge is set to the exchange stage, the specified volume of solution is exchanged immediately. We experimentally examine the solution exchange, and demonstrate the response of a sensor cell to a chemical stimulus in the exchanged solution. We consider that the device would be useful to produce multiple types of sensor cells.

Access to Document (DOI)

Inverse problems in tactile displays

Miki N., Ishizuka H.

Proceedings of the International Display Workshops （Proceedings of the International Display Workshops） 27 929 - 930 2021年12月

ISSN 18832490

Tactile displays, which present virtual surfaces and tactile information to the users, can potentially augment quality and quantity of information in human-computer interaction. In this presentation, we discuss how we solve the inverse problems of the tactile displays, i.e., how to derive the control parameters of the displays when the target tactile sensations are given, in which we propose the microfabricated tactile samples to deduce quantitative correlation between the surface properties and tactile perception.

Electropolishing parametric optimization of surface quality for the fabrication of a titanium microchannel using the taguchi method

Mahardika M., Setyawan M.A., Sriani T., Miki N., Prihandana G.S.

Machines （Machines） 9 （ 12 ） 2021年12月

Titanium is widely used in biomedical components. As a promising advanced manufacturing process, electropolishing (EP) has advantages in polishing the machined surfaces of material that is hard and difficult to cut. This paper presents the fabrication of a titanium microchannel using the EP process. The Taguchi method was adopted to determine the optimal process parameters by which to obtain high surface quality using an L9 orthogonal array. The Pareto analysis of variance was utilized to analyze the three machining process parameters: applied voltage, concentration of ethanol in an electrolyte solution, and machining gap. In vitro experiments were conducted to investigate the fouling effect of blood on the microchannel. The result shows that an applied voltage of 20 V, an ethanol concentration of 20 vol.%, and a machining gap of 10 mm are the optimum machining parameters by which to enhance the surface quality of a titanium microchannel. Under the optimized machining parameters, the surface quality improved from 1.46 to 0.22 µm. Moreover, the adhesion of blood on the surface during the fouling experiment was significantly decreased, thus confirming the effectiveness of the proposed method.

Access to Document (DOI)

Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices

Kono R., Ota T., Ito T., Miyaoka Y., Ishibashi H., Kanno Y., Miki N.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference （Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference） 2021 5051 - 5054 2021年11月

ISSN 1557170X

In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.

Access to Document (DOI)

Micro Elastic Pouch Motors: Elastically Deformable and Miniaturized Soft Actuators Using Liquid-to-Gas Phase Change

Hirai S., Nagatomo T., Hiraki T., Ishizuka H., Kawahara Y., Miki N.

IEEE Robotics and Automation Letters （IEEE Robotics and Automation Letters） 6 （ 3 ） 5373 - 5380 2021年07月

In the present study, we propose a largely deformable and miniaturized soft actuator that is made by an elastic rubber bladder (called a pouch) with a low-boiling-point liquid. When the temperature of the low-boiling-point liquid reaches 34 - C, the liquid inside the pouch evaporates, and the whole structure inflates. Thanks to the proposed fabrication method, we can make a miniaturized pouch of approximately 5 mm in diameter with a thin rubber membrane, and the pouch can inflate to a volume of 86 times or more compared to its initial volume and can generate approximately 20 N at maximum. We calculated the deformation model and developed the fabrication process through investigation of the thickness and the inflation volume of the pouch with respect to the process parameters. We then experimentally characterized the actuator with respect to the generated force, time response, and repeatability of the inflation. We believe that micro elastic pouch motors will contribute to soft robotic systems as a new component as a result of having unique characteristics, such as millimeter size and large deformability.

Access to Document (DOI)

Efficient Gas-to-Liquid Partition Using Gas-Flow Channels for Cell-Based Gaseous Odorant Detection

Nakane T., Osaki T., Mimura H., Miki N., Takeuchi S.

21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 （21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021） 763 - 766 2021年06月

ISSN 9781665412674

Cell-based sensors using olfactory receptors have attracted attention because of their high sensitivity and selectivity. A challenge is efficient partition of gaseous samples to the aqueous solution where the cell-based sensors reside. In this paper, we developed a device with a gas-flow channel, which allowed inflow of gaseous odorants over a well filled with aqueous solution. We considered that shear stress induced by the gas-flow at the gas-liquid interface initiate convectional mixing inside liquid and in turn, promotes partitioning of gaseous odorants into the solution. Solubility of a gaseous odorant was experimentally found to increase with the mixing strength. We further demonstrated efficient detection of a gaseous odorant using the sensor cells with the developed gas-flow device.

Access to Document (DOI)

Unsupervised Learning Enables Extraction of Tactile Information from Text Database

Nagatomo T., Hiraki T., Ishizuka H., Miki N.

IEEE Access （IEEE Access） 2021年

In this work, we propose a new approach to tactile research using natural language processing of archival word corpus as the database. Tactile perception, or assessment of surfaces, is recognized as a language. Thus, by extracting touch-related words and sentences from a text corpus and learning their relationships, we can ultimately learn how humans perceive surfaces. We selected 6 adjectives and 42 onomatopoeias in Japanese as our tactile words. The adjectives represent physical properties, such as roughness and hardness, while onomatopoeias, such as “zara-zara” and “tsuru-tsuru,” are widely used to describe surfaces in Japanese and can correspond to both physical texture cognition and affective cognition. First, using natural language processing of word corpora, we successfully mapped the onomatopoeias with respect to the 6 adjectives, which matched well with the results based on an enquete-based survey. This verified the effectiveness of natural language processing for tactile research. In addition, principal component analysis revealed new tactile dimensions based on onomatopoeias, which we presumably assessaffective tactile dimensions. The proposed approach using natural language processing of archival text databases can provide a large number of datasets for tactile research and culminate in new findings and insights.

Access to Document (DOI)

RELIABLE RE-FORMATION OF A LIPID BILAYER USING A GEOMETRICALLY GUIDED AIR BUBBLE

Hashimoto I., Osaki T., Sugiura H., Mimura H., Miki N., Takeuchi S.

MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences （MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences） 351 - 352 2021年

This paper reports successful re-formation of a lipid bilayer using an air bubble. Lipid bilayers have been used for membrane protein studies and biosensor applications. Droplet-contact-method is a simple and effective method to form the bilayers. A major challenge in using the bilayers originates from their vulnerability against physical and electrical disturbance, which leads the bilayer rapture and the droplet fusion. We previously proposed a concept to re-form a bilayer by introducing an air bubble to cut-and-split the merged droplet. In this work, we investigated the key parameters to guide the bubble and drastically enhanced the yield up to 97%.

Rapid and Resilient Detection of Toxin Pore Formation Using a Lipid Bilayer Array

Ito Y., Osaki T., Kamiya K., Yamada T., Miki N., Takeuchi S.

Small （Small） 16 （ 49 ） 2020年12月

ISSN 16136810

An artificial cell membrane is applied to study the pore formation mechanisms of bacterial pore-forming toxins for therapeutic applications. Electrical monitoring of ionic current across the membrane provides information on the pore formation process of toxins at the single pore level, as well as the pore characteristics such as dimensions and ionic selectivity. However, the efficiency of pore formation detection largely depends on the encounter probability of toxin to the membrane and the fragility of the membrane. This study presents a bilayer lipid membrane array that parallelizes 4 or 16 sets of sensing elements composed of pairs of a membrane and a series electrical resistor. The series resistor prevents current overflow attributed to membrane rupture, and enables current monitoring of the parallelized membranes with a single detector. The array system shortens detection time of a pore-forming protein and improves temporal stability. The current signature represents the states of pore formation and rupture at respective membranes. The developed system will help in understanding the toxic activity of pore-forming toxins.

Access to Document (DOI)

Pipette Based Viscometer with Pressure Sensor Element

Cho S., Nguyen T.V., Miki N., Takahashi H.

ISSN 9781728135809

© 2020 IEEE. This paper reports a simple viscometer, whose principle utilizes the relationship between liquid viscosity and the suction speed in a tube. The proposed viscometer is composed of an air chamber and a glass tube. A steel ball is attached to the silicone membrane of the chamber and an electromagnetic magnet is used to provide the volume change. A MEMS pressure sensor element is attached to the chamber to measure its pressure change. When a step-response volume change is applied, the chamber pressure decreases so that the liquid sticking to the tube gradually ascends at a speed depending to the viscosity. Thus, the viscosity can be calculated by measuring the gradient of the pressure change. The proposed method can be applied to micropipettes so that viscosity is easily measured with a simple device.

Access to Document (DOI)

Bubble-Assisted in-Situ Re-Formation of Artificial Bilayer

Hashimoto I., Sugiura H., Osaki T., Yamada T., Mimura H., Miki N., Takeuchi S.

ISSN 9781728135809

© 2020 IEEE. This paper proposes a technique to reconstitute a lipid bilayer membrane by injecting an air bubble onto the raptured spot. Our group has been studying the artificial bilayer that can host membrane proteins and can be a fundamental to analyze their functions. The only drawback of the lipid bilayer formed at the interface of two water-in-oil droplets is its sustainability, namely, the bilayer often collapses and the droplets merges by the disturbance like self-exerted oscillation or sloshing. To overcome this issue, the newly proposed technique utilizes a bubble at approximately 4μL in volume. When the bubble is injected and retracted, the new artificial bilayer is reconstituted. The major advantage of this technique is the in-situ reconstitution of the bilayer during the electrical measurement of the membrane proteins. The proposed technique was successfully verified by confirming the emergence of nanopore membrane proteins.

Access to Document (DOI)

'Coat Pop': On-Substrate Two-Step Composition Patterning Method of Liquid Metal Alloys for Flexible Devices

David R., Miki N.

ISSN 9781728135809

© 2020 IEEE. We have developed a novel on-substrate composition patterning process of room-temperature liquid metal alloys via a simple two-step method: 'coat pop'. This work present for the first time the integration of a single or several noble metals (Au, Ag or Cu) on Ga-based liquid metal droplets on a single substrate, by using a spontaneous chemical reaction then simple mechanical compression, to form biphasic and liquid composition patterns. The controllable deposition of noble metals encapsulation patterns and formation of several interfaced conductive biphasic intermetallic alloys on a single substrate were successfully demonstrated.

Access to Document (DOI)

Towards realization of implantable dialysis system

Miki N.

Journal of Japan Institute of Electronics Packaging （Journal of Japan Institute of Electronics Packaging） 23 （ 5 ） 393 - 397 2020年

ISSN 13439677

Access to Document (DOI)

　前のページ - 次のページ　

三木 則尚

論文 - 三木 則尚

三木　則尚

論文 - 三木　則尚