Miki, Norihisa

写真a

Affiliation

Faculty of Science and Technology, Department of Mechanical Engineering （Yagami）

Position

Professor
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Profile Summary 【 Display / hide 】

  • '''''''MEMS (MicroElectroMechanical Systems) Technology has enabled manufacturing of micro/nanoscale structures. A wide variety of sensors, actuators, and chemical/bio chips have been developed by exploiting the virtues of their small sizes and scale effects. Our laboratory focuses on innovative micro/nano-fabrication technologies, human-interface devices, micro-fluidic devices utilized for bio/medical applications, and power MEMS devices.'''''''

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Career 【 Display / hide 】

  • 2001.04
    -
    2003.03

    Postdoctoral Associate, Dept. of Aeronautics and Astronautics, Massachusetts Institute of Technology, USA

  • 2003.04
    -
    2004.03

    Research Engineer, Dept. of Aeronautics and Astronautics, Massachusetts Institute of Technology, USA

  • 2006.12
    -
    2009.03

    神奈川科学技術アカデミー非常勤研究員

  • 2008.07
    -
    2010.03

    大学院FD委員会委員

  • 2008.07
    -
    2013.03

    LifeBEANS Center, BEANS Laboratory

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Academic Background 【 Display / hide 】

  • 1996.03

    The University of Tokyo, Faculty of Engineering, Department of Mechanical Engineering

    University, Graduated

  • 2001.03

    The University of Tokyo, Graduate School, Division of Engineering, Mechano-Informatics

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士(工学）, The University of Tokyo, Coursework, 2001.03

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Research Areas 【 Display / hide 】

  • Informatics / Mechanics and mechatronics (Intelligent Mechanics/Mechanical System)

  • Informatics / Robotics and intelligent system (Intelligent Mechanics/Mechanical System)

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Research Keywords 【 Display / hide 】

  • MEMS

  • Interaction

  • Human Interface

  • Healthcare

  • Micro/Nano

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Books 【 Display / hide 】

  • 透過式ウェアラブル視線検出システムを用いたヒトモニタリング

    三木則尚, 2018.02

    Scope: VR/AR技術の開発動向と最新応用事例　第6章第4節 pp.251-260

  • 色素増感素子を用いた透過式ウェアラブル視線検出システム、ウェアラブル・エレクトロニクス

    三木則尚, 株式会社エヌ・ティー・エス, 2014.06

  • ナノテクノロジーを用いたマイクロダイアライザーの開発, 全人力・科学力・透析力 for the people 透析医学

    菅野義彦, 三木則尚, 医薬ジャーナル社, 2014.06

    Scope: pp. 202-204

  • Advances in Micro/Nano Electromechanical Systems and Fabrication Technologies

    Norihisa Miki, INTECH, 2013

  • Advanced Bio/Medical Devices and Equipments for Health Care

    MIKI NORIHISA, シーエムシー出版, 2009.05

    Scope: 37-52

    　View Summary

    患者のQOLを向上する医療に貢献するマイクロデバイスとして、カプセル型内視鏡の電源となる胃酸発電池、携帯できる人工透析デバイスを紹介した。

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Papers 【 Display / hide 】

  • Relationship between Interoceptive Accuracy and Tactile Exploration Behavior

    H. Aso, H. Ishizuka, T. Hiraki, Y. Minagawa, N. MIki

    IEEE Access  2024

    Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

  • Microfabricated Nitinol Stent Retrievers with a Micro-Patterned Surface

    Kato S., Ban Y., Ota T., Miki N.

    Micromachines （Micromachines)  15 （ 2 ）  2024.02

    Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

    　View Summary

    Stent retrievers are medical devices that are designed to physically remove blood clots from within the blood vessels of the brain. This paper focuses on microfabricated nitinol (nickel–titanium alloy) stent retrievers, which feature micro-patterns on their surface to enhance the effectiveness of mechanical thrombectomy. A thick film of nitinol, which was 20 µm in thickness, was sputtered onto a substrate with a micro-patterned surface, using electroplated copper as the sacrificial layer. The nitinol film was released from the substrate and then thermally treated while folded into a cylindrical shape. In vitro experiments with pig blood clots demonstrated that the micro-patterns on the surface improved the efficacy of blood clot retrieval.

  • Reproducible reformation of a bilayer lipid membrane using microair bubbles

    Hashimoto I., Osaki T., Sugiura H., Mimura H., Takamori S., Miki N., Takeuchi S.

    Droplet （Droplet)  2 （ 3 ）  2023.07

    Research paper (scientific journal),  ISSN  27692159

    　View Summary

    Planar bilayer lipid membranes (BLMs) are widely used as models for cell membranes in various applications, including drug discovery and biosensors. However, the nanometer-thick bilayer structure, assembled through hydrophobic interactions of amphiphilic lipid molecules, makes such BLM systems mechanically and electrically unstable. In this study, we developed a device to reform BLMs using a microair bubble. The device consists of a double well divided by a separator with a microaperture, where a BLM was formed by infusing a lipid-dispersed solvent and an aqueous droplet into each well in series. When the BLM ruptured, a microair bubble was injected from the bottom of the well to split the merged aqueous droplet at the microaperture, which resulted in the reformation of two lipid monolayers on the split droplets. By bringing the two droplets into contact, a new BLM was formed. An angled step design was introduced in the BLM device to guide the bubble and ensure the splitting of the merged droplet. We also elucidated the optimal bubble inflow rate for the reproducible BLM reformation. Using a 4-channel parallel device, we demonstrated the individual and repeatable reformation of BLMs. Our approach will aid the development of automated and arrayed BLM systems.

  • Real-time quantitative characterization of ion channel activities for automated control of a lipid bilayer system

    Ogishi K., Osaki T., Mimura H., Hashimoto I., Morimoto Y., Miki N., Takeuchi S.

    Biosensors and Bioelectronics （Biosensors and Bioelectronics)  237 2023.10

    Research paper (scientific journal), Accepted,  ISSN  09565663

    　View Summary

    This paper describes a novel signal processing method to characterize the activity of ion channels on a lipid bilayer system in a real-time and quantitative manner. Lipid bilayer systems, which enable single-channel level recordings of ion channel activities against physiological stimuli in vitro, are gaining attention in various research fields. However, the characterization of ion channel activities has heavily relied on time-consuming analyses after recording, and the inability to return the quantitative results in real time has long been a bottleneck to incorporating the system into practical products. Herein, we report a lipid bilayer system that integrates real-time characterization of ion channel activities and real-time response based on the characterization result. Unlike conventional batch processing, an ion channel signal is divided into short segments and processed during the recording. After optimizing the system to maintain the same characterization accuracy as conventional operation, we demonstrated the usability of the system with two applications. One is quantitative control of a robot based on ion channel signals. The velocity of the robot was controlled every second, which was around tens of times faster than the conventional operation, in proportion to the stimulus intensity estimated from changes in ion channel activities. The other is the automation of data collection and characterization of ion channels. By constantly monitoring and maintaining the functionality of a lipid bilayer, our system enabled continuous recording of ion channels over 2 h without human intervention, and the time of manual labor has been reduced from conventional 3 h to 1 min at a minimum. We believe the accelerated characterization and response in the lipid bilayer systems presented in this work will facilitate the transformation of lipid bilayer technology toward a practical level, finally leading to its industrialization.

  • ProtoHand: Solderless Prototyping of Electrical Circuits on a Soft Artificial Hand with Liquid Metal

    Yamaguchi S., Nakano N., Hiraki T., Ishizuka H., Miki N.

    IEEE Sensors Letters （IEEE Sensors Letters)  7 （ 3 ）  2023.03

    Research paper (scientific journal), Last author, Corresponding author, Accepted

    　View Summary

    In this letter, we propose and demonstrate ProtoHand, which is a soft artificial hand that can work as a universal platform for prototyping electrical circuits similar to a breadboard. ProtoHand is made of flexible and transparent polydimethyl siloxane. ProtoHand has multiple channels filled with liquid metal beneath the surface, like the blood vessels of a hand. Electric components, such as resistors and capacitors, can be inserted by piercing into ProtoHand and electrically connected via the conductive liquid metal. Soldering is unnecessary, and the parts can be removed without leakage of the liquid metal; therefore, prototyping of electric circuits can be performed on this soft hand in a reusable manner. ProtoHand will help the design of multifunctional robot hands and could also be an excellent educational tool.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ソルトチップでおいしく減塩

    三木則尚

    臨床栄養 (医歯薬出版株式会社)  132 ( 2 ) 138 - 139 2018.02

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

  • 体内植込み式人工腎臓の現況と未来

    三木 則尚、菅野義彦

    腎臓内科・泌尿器科 (科学評論社)  5 ( 5 ) 482 - 487 2017.05

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • マイクロ・ナノ医療デバイス実用化への課題─インプラント人工透析システムを例に─

    三木 則尚

    エレクトロニクス実装学会誌 20 ( 2 ) 109 - 112 2017.03

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • Electrospray formation of ring-shaped silica nanoparticles

    Kazuhiro Uchida, Kazuhiko Higashi, Koichi Hishida, Atsushi Hotta,Norihisa Miki

    Japanese Journal of Applied Physics Rapid Communications 54   020302 2015.01

    Rapid communication, short report, research note, etc. (scientific journal), Joint Work

  • MEMS-based Tactile Displays

    H. Ishizuka & N. Miki

    Displays (Elsevier)  37   25 - 32 2015

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • Electroencephalogram Measurement in Adapting Process to Inverse Vision

    T.Onomoto, Y. Yoshida, N. Miki

    International Conference on Electronics Packaging(ICEP2019) (Niigata, Japan) , 

    2019.04
    , 

    Oral presentation (general)

  • Long-term in vivo Experiment Protocol Using SD Rats

    T.Ito, Y.Koya, N.Miki

    International Conference on Electronics Packaging(ICEP2019) (Niigata, Japan) , 

    2019.04
    , 

    Oral presentation (general)

  • Azinzo Project

    A.Watanabe, N.Miki

    Hellow Tomorrow Global Summit (Paris, France) , 

    2019.03
    , 

    Oral presentation (general)

  • A Precise Sampling Strip with Microstructures

    H.Kamiya, T.Ohta, H.Yasuga, N.Miki

    40th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2018), 

    2018.07
    , 

    Oral presentation (general)

  • Microbes culture systems using cellulose tubes and photocatalyst-coated glass balls

    K.Saito, K.Fujimoto, K.Higashi, N.Miki

    40th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2018), 

    2018.07
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Objective and Quantitative Assessment of Reproduction of Tactile Feeling

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 同期する脳を用いた協働場の評価と創成　双方向脳神経科学の開拓研究

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

  • Approach to inverse problems of tactile display using tactile samples

    2018.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

  • Jisso Technologies for Micro-Nano Medical Devices

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 単結晶ダイヤモンドのパラレルプロセッシングによる超微細工具開発研究

    2008.04
    -
    2010.03

    厚生労働科学研究費補助金　財団法人みずほ学術振興財団研究助成, Research grant, No Setting

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Works 【 Display / hide 】

  • 第１０５回マイクロ接合研究委員会「医療用マイクロ・ナノデバイスのための加工・表面処理技術 - マイクロ透析システムを例をとって –」

    三木 則尚

    2013.11
    -
    Present
    , 

    Other, Single

  • MEMS実装パッケージング・フォーラム，ナノ・マイクロビジネス展「医療用MEMSの人工透析システムへの応用」

    三木 則尚

    2013.07
    -
    Present
    , 

    Other, Single

  • 新川崎創造のもりキャンパス　オープンセミナー 「人に関わるMEMS :医療からICTまで」

    三木 則尚

    2012.03
    -
    Present
    , 

    Other, Single

  • 第90回慶應医学会総会・シンポジウム「マイクロ流体システムを用いた超小型透析装置の開発」

    MIKI NORIHISA

    2010.11
    -
    Present
    , 

    Other, Single

  • 第19回MEMSPCカフェ「ポリマー材料の特性を生かした高機能マイクロデバイス」

    MIKI NORIHISA

    2010.10
    -
    Present
    , 

    Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 瞳検出方法、瞳位置検出装置及び透過型視線検出装置

    Date applied： 特願2006-018591  2006.01 

    Date announced： 特開2007-195775  2007.08 

    Patent, Joint

  • 表面増強ラマン分光分析用基板の作成方法及び表面増強ラマン分光分析用基板

    Date applied： 特願2006-018555  2006.01 

    Date announced： 特開2007-198933  2007.08 

    Patent, Joint

  • 体内飲み込み型発電池

    Date applied： 特願2006-018571  2006.01 

    Date announced： 特開2007-200739  2007.08 

    Patent, Joint

  • 血液濾過装置

    Date applied： 特願2016-046355  2016.03 

    Patent, Joint

  • 液滴アレイ形成用のマイクロウェルプレート及び液滴アレイの製造方法

    Date applied： 2016-127183  2016 

    Patent, Joint

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Awards 【 Display / hide 】

  • 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰

    2022.02, 日本機械学会マイクロ・ナノ工学部門

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 次世代リーダービジネスプランコンテスト　特別賞

    2020.08

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本機械学会マイクロ・ナノ工学部門貢献表彰

    2019.11, 日本機械学会マイクロ・ナノ工学部門

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • SI2016優秀講演賞

    石塚裕己、畑田龍平、三木則尚, 2016.12, 第17回公益社団法人計測自動制御学会　システムインテグレーション部門講演会

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰

    荒井都子、工藤優汰、三木則尚, 2016.12, 日本機械学会マイクロ・ナノ工学部門

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Other 【 Display / hide 】

  • 2017年10月

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    日経新聞　人工腎臓

  • 2017年10月

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    NHKテキスト　きょうの健康　2017年11月号
    研究室訪問

  • 2017年09月

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    朝日新聞　人工腎臓

  • 2017年08月

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    朝日新聞夕刊　塩チップおいしく減塩

  • 2017年08月

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    日経夕刊１面　「十分な塩味演出　歯の裏にチップ」

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Courses Taught 【 Display / hide 】

  • SPECIAL LECTURE SERIES ON MULTIDISCIPLINARY AND DESIGN SCIENCE

    2024

  • RESEARCH SKILLS

    2024

  • PROJECT LABORATORY IN MECHANICAL ENGINEERING

    2024

  • MEMS: DESIGN AND FABRICATION

    2024

  • INTRODUCTION TO INTERDISCIPLINARY SCIENCE AND TECHNOLOGY

    2024

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Social Activities 【 Display / hide 】

  • NEDO技術委員

    2015.07
    -
    2017.03

  • ナノテクノロジー・材料技術分野の技術ロードマップ策定に関する調査 ヘルスケア材料ワーキンググループ委員

    2015.01
    -
    2015.03

  • 独立行政法人科学技術振興機構研究開発戦略センター「電子情報通信分野俯瞰プロジェクトⅤ」未来研究開発検討委員会

    2011.08
    -
    Present

  • 「異分野融合型次世代デバイス製造技術開発プロジェクト」に関するシミュレーション委員会・財団法人マイクロマシンセンターBEANSプロジェクト

    2008.07
    -
    2013.03

  • NEDO　MEMSの技術戦略等検討委員会

    2007.11
    -
    2008.03

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Memberships in Academic Societies 【 Display / hide 】

  • Micro Nano Processing Conference (MNC2013), 

    2012.10
    -
    Present

  • MEMS 2014, 

    2013.04
    -
    Present

  • Transducers 2013, 

    2012.10
    -
    Present

  • 日本機械学会ロボメカ部門, 

    2013.03
    -
    2013.04

  • 日本機械学会, 

    2012.04
    -
    2013.03

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Committee Experiences 【 Display / hide 】

  • 2022.04
    -
    2023.03

    副部門長, 日本機械学会マイクロ・ナノ工学部門

  • 2020.04
    -
    2021.03

    アセアン工学系高等教育ネットワークプロジェクト・フェーズ４分野幹事大学委員会委員, 独立行政法人　国際協力機構

  • 2018.04
    -
    2019.12

    実行委員長, 日本機械学会マイクロ・ナノ工学部門　第９回マイクロ・ナノ工学シンポジウム

  • 2018.01
    -
    Present

    評議員, 日本医工ものづくりコモンズ

  • 2017.11
    -
    2018.09

    幹事, 平成30年度E部門総合研究会論文委員会

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