Miki, Norihisa

写真a

Affiliation

Faculty of Science and Technology, Department of Mechanical Engineering (Yagami)

Position

Professor

E-mail Address

E-mail address

Profile Summary 【 Display / hide

  • '''''''MEMS (MicroElectroMechanical Systems) Technology has enabled manufacturing of micro/nanoscale structures. A wide variety of sensors, actuators, and chemical/bio chips have been developed by exploiting the virtues of their small sizes and scale effects. Our laboratory focuses on innovative micro/nano-fabrication technologies, human-interface devices, micro-fluidic devices utilized for bio/medical applications, and power MEMS devices.'''''''

Career 【 Display / hide

  • 2001.04
    -
    2003.03

    Postdoctoral Associate, Dept. of Aeronautics and Astronautics, Massachusetts Institute of Technology, USA

  • 2003.04
    -
    2004.03

    Research Engineer, Dept. of Aeronautics and Astronautics, Massachusetts Institute of Technology, USA

  • 2006.12
    -
    2009.03

    神奈川科学技術アカデミー非常勤研究員

  • 2008.07
    -
    2010.03

    大学院FD委員会委員

  • 2008.07
    -
    2013.03

    LifeBEANS Center, BEANS Laboratory

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Academic Background 【 Display / hide

  • 1996.03

    The University of Tokyo, Faculty of Engineering, Department of Mechanical Engineering

    University, Graduated

  • 2001.03

    The University of Tokyo, Graduate School, Division of Engineering, Mechano-Informatics

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(工学), The University of Tokyo, Coursework, 2001.03

 

Research Areas 【 Display / hide

  • Intelligent mechanics/Mechanical systems (Intelligent Mechanics/Mechanical System)

Research Keywords 【 Display / hide

  • MEMS

  • Interaction

  • Human Interface

  • Healthcare

  • Micro/Nano

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Books 【 Display / hide

  • 透過式ウェアラブル視線検出システムを用いたヒトモニタリング

    三木則尚, 2018.02

    Scope: VR/AR技術の開発動向と最新応用事例 第6章第4節 pp.251-260

  • 色素増感素子を用いた透過式ウェアラブル視線検出システム、ウェアラブル・エレクトロニクス

    三木則尚, 株式会社エヌ・ティー・エス, 2014.06

  • ナノテクノロジーを用いたマイクロダイアライザーの開発, 全人力・科学力・透析力 for the people 透析医学

    菅野義彦, 三木則尚, 医薬ジャーナル社, 2014.06

    Scope: pp. 202-204

  • Advances in Micro/Nano Electromechanical Systems and Fabrication Technologies

    Norihisa Miki, INTECH, 2013

  • Advanced Bio/Medical Devices and Equipments for Health Care

    MIKI NORIHISA, シーエムシー出版, 2009.05

    Scope: 37-52

     View Summary

    患者のQOLを向上する医療に貢献するマイクロデバイスとして、カプセル型内視鏡の電源となる胃酸発電池、携帯できる人工透析デバイスを紹介した。

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Papers 【 Display / hide

  • Microfluidic screening system based on boron-doped diamond electrodes and dielectrophoretic sorting for directed evolution of NAD(P)-dependent oxidoreductases

    Goto, H., Kanai, Y., Yotsui, A., Shimokihara, S., Shitara, S., Oyobiki, R., Fujiwara, K., Watanabe, T., Einaga, Y., Matsumoto, Y., Miki, N., Doi, N

    Lab on a Chip (Royal Society of Chemistry)  20 ( 4 ) 852 - 861 2020.01

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  14730197

     View Summary

    This journal is © The Royal Society of Chemistry. We report the development of a micro total analysis system (μTAS) based on electrochemical measurements and dielectrophoretic sorting for screening of NAD(P)-dependent oxidoreductases. In this system, the activity of enzymes immobilized on microbeads, together with their encoding DNA, can be measured with a boron-doped diamond (BDD) electrode in each compartment (∼30 nL) of the microfluidic system. The 30 nL droplets containing microbead-displayed genes of enzymes with higher activity can then be recovered by dielectrophoretic sorting. Previously, we developed the NAD(P)H-measuring device containing the BDD electrode for high-throughput measurement of the activity of NAD(P)-dependent oxidoreductases. In this study, we fabricated an encapsulating device and a droplet-sorting device for nanoliter-size droplets, for the first time, and then combined these three devices to construct a μTAS for directed evolution of NAD(P)-dependent oxidoreductases. We confirmed that this system works by proof-of-principle experiments and successfully applied this system for screening of randomized libraries of NAD-dependent dehydrogenases.

  • Synthesis of sub-micrometer biphasic Au-AuGa2 / Liquid Metal frameworks

    Romain David, Norihisa Miki

    Nanoscale (Royal Society of Chemistry)  11   21419 - 21432 2019.10

    Research paper (scientific journal), Joint Work, Accepted

  • Connecting mechanism for artificial blood vessels with high biocompatibility

    Watanabe A., Miki N.

    Micromachines (Micromachines)  10 ( 7 )  2019.07

     View Summary

    © 2019 by the authors. This paper proposes a connecting mechanism for artificial vessels, which can be attached/detached with ease and does not deteriorate the biocompatibility of the vessels at the joint. The inner surface of the artificial vessels is designed to have high biocompatibility. In order to make the best of the property, the proposed connecting mechanism contacts and fixes the two artificial vessels whose contacting edges are turned inside out. In this manner, blood flowing inside the vessels only has contact with the biocompatible surface. The biocompatibility, or biofouling at the joint was investigated after in vitro blood circulation tests for 72 h with scanning electron microscopy. Blood coagulation for a short term (120 min) was evaluated by activated partial thromboplastin time (APTT). A decrease of APTT was observed, although it was too small to conclude that the connector augmented the blood coagulation. The micro dialysis device which our group has developed as the artificial kidney was inserted into the blood circulation system with the connector. Decrease of APTT was similarly small. These experiments verified that the proposed connector can be readily applicable for implantable medical devices.

  • A thermal tactile sensation display with controllable thermal conductivity

    S. Hirai, N. Miki

    Micromachines (MDPI)  10 ( 359 )  2019.05

    Joint Work, Accepted

     View Summary

    © 2019 by the authors. We demonstrate a thermal tactile sensation display that can present various thermal sensations, namely cold/cool/warm/hot feelings, by varying the effective thermal conductivity of the display. Thermal sensation is one of the major tactile sensations and needs to be further investigated for advanced virtual reality/augmented reality (VR/AR) systems. Conventional thermal sensation displays present hot/cold sensations by changing the temperature of the display surface, whereas the proposed display is the first one that controls its effective thermal conductivity. The device contains an air cavity and liquid metal that have low and high thermal conductivity, respectively. When the liquid metal is introduced to fill up the air cavity, the apparent thermal conductivity of the device increases. This difference in the thermal conductivity leads to the users experiencing different thermal tactile sensations. Using this device, the threshold to discriminate the effective thermal conductivity was experimentally deduced for the first time. This thermal tactile display can be a good platform for further study of thermal tactile sensation.

  • Automatic Generation System of Cell-Sized Liposomes

    M. Gotanda, K. Kamiya, T. Osaki, N. Miki, S. Takeuchi

    Sensors and Actuators, B: Chemical (Sensors and Actuators B: Chemical)  292   57 - 63 2019.04

    Research paper (scientific journal), Accepted,  ISSN  09254005

     View Summary

    © 2019 Elsevier B.V. Artificial cell membranes such as liposomes and lipid vesicles have been developed using microfluidic technologies. These technologies have advantages for generating cell-sized liposomes, including a monodispersed and asymmetric lipid composition. Cell-sized asymmetric liposomes with various combinations of asymmetric lipid leaflets are sequentially produced using an improved pulsed-jetting device with the six wells arranged on a circular rotation table by manual manipulation. In this study, we reveal optimal parameters of rotation speed and jetting timing for the cell-sized liposome formation using an automatic sequential liposome generation system driven by a stepping motor. First, we optimize the rotation speed of the stepping motor for forming the planar lipid bilayer under control of a microcomputer. Next, we generate cell-sized liposomes using this automated system at the optimized rotation speed. This automatic system will contribute to high-throughput investigations of membrane protein activities and functions using the electrophysiological or the asymmetric liposome analyses.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • ソルトチップでおいしく減塩

    三木則尚

    臨床栄養 (医歯薬出版株式会社)  132 ( 2 ) 138 - 139 2018.02

    Introduction and explanation (commerce magazine), Single Work

  • 体内植込み式人工腎臓の現況と未来

    三木 則尚、菅野義彦

    腎臓内科・泌尿器科 (科学評論社)  5 ( 5 ) 482 - 487 2017.05

    Introduction and explanation (scientific journal), Joint Work

  • マイクロ・ナノ医療デバイス実用化への課題─インプラント人工透析システムを例に─

    三木 則尚

    エレクトロニクス実装学会誌 20 ( 2 ) 109 - 112 2017.03

    Introduction and explanation (scientific journal), Single Work

  • Electrospray formation of ring-shaped silica nanoparticles

    Kazuhiro Uchida, Kazuhiko Higashi, Koichi Hishida, Atsushi Hotta,Norihisa Miki

    Japanese Journal of Applied Physics Rapid Communications 54   020302 2015.01

    Prompt report, short report, and research note, etc. (scientific journal), Joint Work

  • MEMS-based Tactile Displays

    H. Ishizuka & N. Miki

    Displays (Elsevier)  37   25 - 32 2015

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide

  • Electroencephalogram Measurement in Adapting Process to Inverse Vision

    T.Onomoto, Y. Yoshida, N. Miki

    International Conference on Electronics Packaging(ICEP2019) (Niigata, Japan) , 2019.04, Oral Presentation(general)

  • Long-term in vivo Experiment Protocol Using SD Rats

    T.Ito, Y.Koya, N.Miki

    International Conference on Electronics Packaging(ICEP2019) (Niigata, Japan) , 2019.04, Oral Presentation(general)

  • Azinzo Project

    A.Watanabe, N.Miki

    Hellow Tomorrow Global Summit (Paris, France) , 2019.03, Oral Presentation(general)

  • A Precise Sampling Strip with Microstructures

    H.Kamiya, T.Ohta, H.Yasuga, N.Miki

    40th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2018), 2018.07, Oral Presentation(general)

  • Microbes culture systems using cellulose tubes and photocatalyst-coated glass balls

    K.Saito, K.Fujimoto, K.Higashi, N.Miki

    40th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2018), 2018.07, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Objective and Quantitative Assessment of Reproduction of Tactile Feeling

    2020.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 三木 則尚, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 同期する脳を用いた協働場の評価と創成 双方向脳神経科学の開拓研究

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 三木 則尚, Grant-in-Aid for Challenging Research (Exploratory) , Principal Investigator

  • Approach to inverse problems of tactile display using tactile samples

    2018.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 三木 則尚, Grant-in-Aid for Scientific Research on Innovative Areas, Principal Investigator

  • Jisso Technologies for Micro-Nano Medical Devices

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 三木 則尚, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 単結晶ダイヤモンドのパラレルプロセッシングによる超微細工具開発研究

    2008.04
    -
    2010.03

    厚生労働科学研究費補助金 財団法人みずほ学術振興財団研究助成, Research grant

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Works 【 Display / hide

  • 第105回マイクロ接合研究委員会「医療用マイクロ・ナノデバイスのための加工・表面処理技術 - マイクロ透析システムを例をとって –」

    三木 則尚

    2013.11
    -
    Present

    Other, Single

  • MEMS実装パッケージング・フォーラム,ナノ・マイクロビジネス展「医療用MEMSの人工透析システムへの応用」

    三木 則尚

    2013.07
    -
    Present

    Other, Single

  • 新川崎創造のもりキャンパス オープンセミナー 「人に関わるMEMS :医療からICTまで」

    三木 則尚

    2012.03
    -
    Present

    Other, Single

  • 第90回慶應医学会総会・シンポジウム「マイクロ流体システムを用いた超小型透析装置の開発」

    MIKI NORIHISA

    2010.11
    -
    Present

    Other, Single

  • 第19回MEMSPCカフェ「ポリマー材料の特性を生かした高機能マイクロデバイス」

    MIKI NORIHISA

    2010.10
    -
    Present

    Other, Single

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Intellectual Property Rights, etc. 【 Display / hide

  • 瞳検出方法、瞳位置検出装置及び透過型視線検出装置

    Application No.: 特願2006-018591  2006.01 

    Announcement No.: 特開2007-195775  2007.08 

    Patent, Joint, National application

  • 表面増強ラマン分光分析用基板の作成方法及び表面増強ラマン分光分析用基板

    Application No.: 特願2006-018555  2006.01 

    Announcement No.: 特開2007-198933  2007.08 

    Patent, Joint, National application

  • 体内飲み込み型発電池

    Application No.: 特願2006-018571  2006.01 

    Announcement No.: 特開2007-200739  2007.08 

    Patent, Joint, National application

  • 血液濾過装置

    Application No.: 特願2016-046355  2016.03 

    Patent, Joint

  • 液滴アレイ形成用のマイクロウェルプレート及び液滴アレイの製造方法

    Application No.: 2016-127183  2016 

    Patent, Joint

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Awards 【 Display / hide

  • SI2016優秀講演賞

    石塚裕己、畑田龍平、三木則尚, 2016.12, 第17回公益社団法人計測自動制御学会 システムインテグレーション部門講演会

    Type of Award: Awards of National Conference, Council and Symposium.  Country: 日本

  • 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰

    荒井都子、工藤優汰、三木則尚, 2016.12, 日本機械学会マイクロ・ナノ工学部門

    Type of Award: Awards of National Conference, Council and Symposium.  Country: 日本

  • Sixth Japan-America Frontiers of Engineering Symposium, Best Poster Presenter Award

    MIKI NORIHISA, 2006.11, National Academy of Engineering, Engineering Academy of Japan, Japan Science and Technology Agency, Nano/Micro Fabrication Enabling Technology

    Type of Award: International Academic Awards

  • 工作機械技術振興財団「工作機械技術振興賞」奨励賞

    松下孟,三木 則尚, 2006.05, 工作機械技術振興財団, フォトリソグラフィーを用いた超微細ダイヤモンド工具の開発

    Type of Award: Awards of Publisher, Newspaper Company and Foundation

  • 日本ロボット学会研究奨励賞

    三木則尚, 2000, 日本ロボット学会, マイクロ飛行ロボットに関する研究(第17回学術講演会)

    Type of Award: Awards of National Conference, Council and Symposium

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Other 【 Display / hide

  • 2017年10月

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    日経新聞 人工腎臓

  • 2017年10月

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    NHKテキスト きょうの健康 2017年11月号
    研究室訪問

  • 2017年09月

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    朝日新聞 人工腎臓

  • 2017年08月

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    朝日新聞夕刊 塩チップおいしく減塩

  • 2017年08月

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    日経夕刊1面 「十分な塩味演出 歯の裏にチップ」

 

Courses Taught 【 Display / hide

  • GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 1

    2020

  • ETHICS FOR CREATIVE ENGINEERS

    2020

  • DESIGN PROJECT IN MECHANICAL ENGINEERING

    2020

  • COMPUTATIONAL ANALYSIS OF MECHANICAL PRODUCTS

    2020

  • BACHELOR'S THESIS

    2020

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Social Activities 【 Display / hide

  • NEDO技術委員

    2015.07
    -
    2017.03
  • ナノテクノロジー・材料技術分野の技術ロードマップ策定に関する調査 ヘルスケア材料ワーキンググループ委員

    2015.01
    -
    2015.03
  • 独立行政法人科学技術振興機構研究開発戦略センター「電子情報通信分野俯瞰プロジェクトⅤ」未来研究開発検討委員会

    2011.08
    -
    Present
  • 「異分野融合型次世代デバイス製造技術開発プロジェクト」に関するシミュレーション委員会・財団法人マイクロマシンセンターBEANSプロジェクト

    2008.07
    -
    2013.03
  • NEDO MEMSの技術戦略等検討委員会

    2007.11
    -
    2008.03

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Memberships in Academic Societies 【 Display / hide

  • Micro Nano Processing Conference (MNC2013), 

    2012.10
    -
    Present
  • MEMS 2014, 

    2013.04
    -
    Present
  • Transducers 2013, 

    2012.10
    -
    Present
  • 日本機械学会ロボメカ部門, 

    2013.03
    -
    2013.04
  • 日本機械学会, 

    2012.04
    -
    2013.03

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Committee Experiences 【 Display / hide

  • 2020.04
    -
    2021.03

    アセアン工学系高等教育ネットワークプロジェクト・フェーズ4分野幹事大学委員会委員, 独立行政法人 国際協力機構

  • 2018.04
    -
    2019.12

    実行委員長, 日本機械学会マイクロ・ナノ工学部門 第9回マイクロ・ナノ工学シンポジウム

  • 2018.01
    -
    Present

    評議員, 日本医工ものづくりコモンズ

  • 2017.11
    -
    2018.09

    幹事, 平成30年度E部門総合研究会論文委員会

  • 2017.03
    -
    2018.11

    実行委員長, 日本機械学会マイクロ・ナノ工学部門 第8回マイクロ・ナノ工学シンポジウム

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