KEIO RESEARCHERS INFORMATION SYSTEM

Profile Summary 【 Display / hide 】

Profile Summary 【 Display / hide 】

• '''''''MEMS (MicroElectroMechanical Systems) Technology has enabled manufacturing of micro/nanoscale structures. A wide variety of sensors, actuators, and chemical/bio chips have been developed by exploiting the virtues of their small sizes and scale effects. Our laboratory focuses on innovative micro/nano-fabrication technologies, human-interface devices, micro-fluidic devices utilized for bio/medical applications, and power MEMS devices.'''''''

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2001.04

  -

  2003.03

  Postdoctoral Associate, Dept. of Aeronautics and Astronautics, Massachusetts Institute of Technology, USA

• 2003.04

  -

  2004.03

  Research Engineer, Dept. of Aeronautics and Astronautics, Massachusetts Institute of Technology, USA

• 2006.12

  -

  2009.03

  神奈川科学技術アカデミー非常勤研究員

• 2008.07

  -

  2010.03

  大学院FD委員会委員

• 2008.07

  -

  2013.03

  LifeBEANS Center, BEANS Laboratory

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1996.03

  The University of Tokyo, Faculty of Engineering, Department of Mechanical Engineering

  University, Graduated

• 2001.03

  The University of Tokyo, Graduate School, Division of Engineering, Mechano-Informatics

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士(工学）, The University of Tokyo, Coursework, 2001.03

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Informatics / Mechanics and mechatronics (Intelligent Mechanics/Mechanical System)

• Informatics / Robotics and intelligent system (Intelligent Mechanics/Mechanical System)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• MEMS

• Interaction

• Human Interface

• Healthcare

• Micro/Nano

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Books 【 Display / hide 】

Books 【 Display / hide 】

• 透過式ウェアラブル視線検出システムを用いたヒトモニタリング

  三木則尚, 2018.02

  Scope: VR/AR技術の開発動向と最新応用事例　第6章第4節 pp.251-260

• 色素増感素子を用いた透過式ウェアラブル視線検出システム、ウェアラブル・エレクトロニクス

  三木則尚, 株式会社エヌ・ティー・エス, 2014.06

• ナノテクノロジーを用いたマイクロダイアライザーの開発, 全人力・科学力・透析力 for the people 透析医学

  菅野義彦, 三木則尚, 医薬ジャーナル社, 2014.06

  Scope: pp. 202-204

• Advances in Micro/Nano Electromechanical Systems and Fabrication Technologies

  Norihisa Miki, INTECH, 2013

• Advanced Bio/Medical Devices and Equipments for Health Care

  MIKI NORIHISA, シーエムシー出版, 2009.05

  Scope: 37-52

  　View Summary

  患者のQOLを向上する医療に貢献するマイクロデバイスとして、カプセル型内視鏡の電源となる胃酸発電池、携帯できる人工透析デバイスを紹介した。

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Sustainable Removal of Spirulina platensis Using PEG-Modified Membranes Derived from EPS Waste

  Kemal Salam Ramadhan, Budi Arifvianto, Muslim Mahardika, Ario Sunar Baskoro, Norihisa Miki, Tutik Sriani and Gunawan Setia Prihandana

  Phycology (MDPI)  6 ( 47 )  2026.04

  Research paper (scientific journal), Accepted

  • Access to Document (DOI)

• Adult Neuromuscular Choristoma of the Mental Nerve: Diagnostic Pitfalls and Surgical Considerations

  Nakao K., Domoto T., Ito D., Yamaga M., Miki N.

  Journal of Craniofacial Surgery Publish Ahead of Print 2026

  ISSN  10492275

  　View Summary

  Neuromuscular choristoma (NMC) is an extremely rare, benign nerve tumor composed of intermingled mature skeletal muscle fibers and nerve bundles. Most cases arise in childhood from major nerves such as the sciatic or brachial plexus. Surgical manipulation, including biopsy or partial excision, has been reported to induce desmoid-type fibromatosis (DTF); therefore, invasive procedures should be avoided. Here, the authors report a case of NMC arising from the mental nerve in a 24-year-old man who presented with a gradually enlarging, soft, and poorly mobile subcutaneous mass with indistinct borders. Magnetic resonance imaging (MRI) revealed findings characteristic of NMC, and en bloc resection, including the overlying skin, was performed. Histopathologic examination revealed mature skeletal muscle fibers intermingled with nerve fascicles, confirming the diagnosis of NMC. No neurological deficits or recurrences occurred during a several-month follow-up. This is the first reported case of adult-onset NMC arising from a peripheral branch and the only second peripheral nerve case worldwide. NMC may mimic lipoma or schwannoma in the craniofacial region, and a biopsy can trigger DTF formation; therefore, noninvasive MRI-based diagnosis and cautious surgical planning are essential.

  • Access to Document (DOI)

• Shape-encoded hydrogel sensor particles enable multiplex odorant detection through deep-learning classification

  S. Takamori, T. Kawakami, T. Ohnishi, H. Miura, T. Osaki, N. Miki, S. Takeuchi

  Small 21 ( 49 )  2025

  Research paper (scientific journal), Joint Work, Accepted,  ISSN  16136810

  　View Summary

  Simultaneous detection of multiple odorants is a major challenge in the development of portable, cell-based biohybrid sensors, primarily due to the difficulty of distinguishing between different sensor cell types. Here, a strategy that encodes odorant sensor cell types using the shape of hydrogel particles, enabling shape-based identification through deep learning is reported. Each particle shape corresponds to a unique sensor cell type expressing a distinct odorant receptor (OR). A convolutional neural network is trained to classify these shapes with high accuracy, and the resulting shape identification scheme is applied to time-lapse fluorescence images of mixed particles exposed to single odorants. This enabled reliable assignment of particle identity and extraction of shape-specific fluorescence signals. Distinct odorant-dependent responses are observed, consistent with the known ligand specificities of the corresponding ORs. While this study focuses on individual odorants, the shape-based approach provides a position-independent, scalable method for multiplexed odorant detection. This framework supports the development of compact, high-throughput biohybrid sensors for safety, environmental monitoring, and diagnostic applications.

  • Access to Document (DOI)

• Design of Polyether sulfone flat-sheet membranes for multi-layered hemodiafiltration devices

  Kono R., Ota T., Kanno Y., Miki N.

  Plos One 20 ( 6 June )  2025.06

  　View Summary

  Multilayered hemodialysis devices enable blood flow without the need for an external pump, whereas hollow fiber-type devices require a pump due to significant pressure loss across the fibers. This highlights a key advantage of multilayered devices for implantable applications, where a simpler and lighter system reduces the burden on patients. This study investigates the mechanical strength and dialysis efficiency of polyether sulfone (PES) flat-sheet membranes for multilayered devices. PES membranes, with thicknesses ranging from 40 to 160 µm, were prepared using the liquid inversion method, with thickness controlled via spin coating. The mechanical strength of the membranes was tested following the ISO 8637–1:2017 protocol, and membranes thicker than 80 µm were experimentally verified to withstand pressures of up to 500 mmHg, making them suitable for dialysis applications. Furthermore, the study demonstrates the successful use of 80 µm membranes in both in vitro and ex vivo experiments with rats, identifying this thickness as optimal for multilayered dialysis devices.

  • Access to Document (DOI)

• Effective Dissolution of a Gaseous Odorant in Liquid Using Gas Flow

  Nakane T., Osaki T., Mimura H., Takamori S., Miki N., Takeuchi S.

  Advanced Materials Technologies 9 ( 23 )  2024

  　View Summary

  Olfactory receptors are known for their high specificity, sensitivity, and nanometer-sized sensing element, making them ideal for in situ odorant sensor applications. However, one of the major limitations of these sensors is the requirement for an aqueous environment to maintain their function, while most odorants are poorly soluble in water. To address this issue, a microfluidic device consisting of a gas-flow channel and a microwell is proposed that enables the effective dissolution of a gaseous odorant in an aqueous solution. Computational simulations are used to design the gas-flow channel and the well, and the performance of the odorant dissolution is verified using the fabricated device. This study considers that convection in water induced by the gas flow enhances the dissolution of a gaseous odorant. The feasibility of the device is demonstrated for on-site detection of a gaseous odorant. This approach facilitates the development of highly responsive and portable sensors utilizing olfactory receptors, offering a promising solution to the limitations of current odorant sensors.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Objective and quantitative assessment of reproduction of tactile feeling

  Miki, Norihisa

  科学研究費補助金研究成果報告書 2023

• Reliability assessment of the implant artificial kidney for the innovative renal replacement therapy

  Miki, Norihisa

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2022

• Reliability assessment of implantable artificial kidney for advanced renal replacement therapy

  Miki, Norihisa

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• Assessment and creation of collaborative space using synchronized brain : pioneering research of bidirectional neuroscience

  Miki, Norihisa

  科学研究費補助金研究成果報告書 2020

• Long-term performance evaluation of implantable dialysis system

  Miki, Norihisa

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2019

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• ソルトチップでおいしく減塩

  三木則尚

  臨床栄養 (医歯薬出版株式会社)  132 ( 2 ) 138 - 139 2018.02

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

• 体内植込み式人工腎臓の現況と未来

  三木 則尚、菅野義彦

  腎臓内科・泌尿器科 (科学評論社)  5 ( 5 ) 482 - 487 2017.05

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

• マイクロ・ナノ医療デバイス実用化への課題─インプラント人工透析システムを例に─

  三木 則尚

  エレクトロニクス実装学会誌 20 ( 2 ) 109 - 112 2017.03

  Article, review, commentary, editorial, etc. (scientific journal), Single Work

• Electrospray formation of ring-shaped silica nanoparticles

  Kazuhiro Uchida, Kazuhiko Higashi, Koichi Hishida, Atsushi Hotta,Norihisa Miki

  Japanese Journal of Applied Physics Rapid Communications 54   020302 2015.01

  Rapid communication, short report, research note, etc. (scientific journal), Joint Work

  • Access to Document (DOI)

• MEMS-based Tactile Displays

  H. Ishizuka & N. Miki

  Displays (Elsevier)  37   25 - 32 2015

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Design of Medical Devices from Multiple Perspectives

  Norihisa Miki

  [International presentation]  JCK MEMS/NEMS 2024 (Chengdu, China) , 

  2024.09

  , 

  Oral presentation (keynote)

• Electroencephalogram Measurement in Adapting Process to Inverse Vision

  T.Onomoto, Y. Yoshida, N. Miki

  [International presentation]  International Conference on Electronics Packaging(ICEP2019) (Niigata, Japan) , 

  2019.04

  , 

  Oral presentation (general)

• Long-term in vivo Experiment Protocol Using SD Rats

  T.Ito, Y.Koya, N.Miki

  [International presentation]  International Conference on Electronics Packaging(ICEP2019) (Niigata, Japan) , 

  2019.04

  , 

  Oral presentation (general)

• Azinzo Project

  A.Watanabe, N.Miki

  [International presentation]  Hellow Tomorrow Global Summit (Paris, France) , 

  2019.03

  , 

  Oral presentation (general)

• A Precise Sampling Strip with Microstructures

  H.Kamiya, T.Ohta, H.Yasuga, N.Miki

  [International presentation]  40th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2018), 

  2018.07

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Understanding Crossmodal Perception for Enhanced Haptic Interfaces

  2025.04

  -

  2029.03

  基盤研究(A), Principal investigator

• Objective and Quantitative Assessment of Reproduction of Tactile Feeling

  2020.04

  -

  2024.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

• 同期する脳を用いた協働場の評価と創成　双方向脳神経科学の開拓研究

  2019.06

  -

  2021.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

• Approach to inverse problems of tactile display using tactile samples

  2018.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas, Principal investigator

• Jisso Technologies for Micro-Nano Medical Devices

  2015.04

  -

  2018.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Works 【 Display / hide 】

Works 【 Display / hide 】

• 第１０５回マイクロ接合研究委員会「医療用マイクロ・ナノデバイスのための加工・表面処理技術 - マイクロ透析システムを例をとって –」

  三木 則尚

  2013.11

  -

  Present

  , 

  Other, Single

• MEMS実装パッケージング・フォーラム，ナノ・マイクロビジネス展「医療用MEMSの人工透析システムへの応用」

  三木 則尚

  2013.07

  -

  Present

  , 

  Other, Single

• 新川崎創造のもりキャンパス　オープンセミナー 「人に関わるMEMS :医療からICTまで」

  三木 則尚

  2012.03

  -

  Present

  , 

  Other, Single

• 第90回慶應医学会総会・シンポジウム「マイクロ流体システムを用いた超小型透析装置の開発」

  MIKI NORIHISA

  2010.11

  -

  Present

  , 

  Other, Single

• 第19回MEMSPCカフェ「ポリマー材料の特性を生かした高機能マイクロデバイス」

  MIKI NORIHISA

  2010.10

  -

  Present

  , 

  Other, Single

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Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• 瞳検出方法、瞳位置検出装置及び透過型視線検出装置

  Date applied： 特願2006-018591  2006.01 

  Date announced： 特開2007-195775  2007.08 

  Patent, Joint

• 表面増強ラマン分光分析用基板の作成方法及び表面増強ラマン分光分析用基板

  Date applied： 特願2006-018555  2006.01 

  Date announced： 特開2007-198933  2007.08 

  Patent, Joint

• 体内飲み込み型発電池

  Date applied： 特願2006-018571  2006.01 

  Date announced： 特開2007-200739  2007.08 

  Patent, Joint

• 血液濾過装置

  Date applied： 特願2016-046355  2016.03 

  Patent, Joint

• 液滴アレイ形成用のマイクロウェルプレート及び液滴アレイの製造方法

  Date applied： 2016-127183  2016 

  Patent, Joint

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰

  2022.02, 日本機械学会マイクロ・ナノ工学部門

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 次世代リーダービジネスプランコンテスト　特別賞

  2020.08

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 日本機械学会マイクロ・ナノ工学部門貢献表彰

  2019.11, 日本機械学会マイクロ・ナノ工学部門

  Type of Award： Award from Japanese society, conference, symposium, etc.

• SI2016優秀講演賞

  石塚裕己、畑田龍平、三木則尚, 2016.12, 第17回公益社団法人計測自動制御学会　システムインテグレーション部門講演会

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰

  荒井都子、工藤優汰、三木則尚, 2016.12, 日本機械学会マイクロ・ナノ工学部門

  Type of Award： Award from Japanese society, conference, symposium, etc.

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Other 【 Display / hide 】

Other 【 Display / hide 】

• 2017年10月

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  日経新聞　人工腎臓

• 2017年10月

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  NHKテキスト　きょうの健康　2017年11月号
  研究室訪問

• 2017年09月

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  朝日新聞　人工腎臓

• 2017年08月

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  朝日新聞夕刊　塩チップおいしく減塩

• 2017年08月

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  日経夕刊１面　「十分な塩味演出　歯の裏にチップ」

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• ETHICS FOR CREATIVE ENGINEERS

  2026

• FACTORY VISITING

  2026

• GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 1

  2026

• OFF-CAMPUS WORK-STUDY PROGRAM

  2026

• PROJECT LABORATORY IN MECHANICAL ENGINEERING

  2026

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Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• NEDO技術委員

  2015.07

  -

  2017.03

• ナノテクノロジー・材料技術分野の技術ロードマップ策定に関する調査 ヘルスケア材料ワーキンググループ委員

  2015.01

  -

  2015.03

• 独立行政法人科学技術振興機構研究開発戦略センター「電子情報通信分野俯瞰プロジェクトⅤ」未来研究開発検討委員会

  2011.08

  -

  Present

• 「異分野融合型次世代デバイス製造技術開発プロジェクト」に関するシミュレーション委員会・財団法人マイクロマシンセンターBEANSプロジェクト

  2008.07

  -

  2013.03

• NEDO　MEMSの技術戦略等検討委員会

  2007.11

  -

  2008.03

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• Micro Nano Processing Conference (MNC2013), 

  2012.10

  -

  Present

• MEMS 2014, 

  2013.04

  -

  Present

• Transducers 2013, 

  2012.10

  -

  Present

• 日本機械学会ロボメカ部門, 

  2013.03

  -

  2013.04

• 日本機械学会, 

  2012.04

  -

  2013.03

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2026.04

  -

  2028.03

  自動車技術会エシカル・エンジニア開発委員会委員, 自動車技術会

• 2023.04

  -

  2024.03

  日本機械学会マイクロ・ナノ工学部門部門長

• 2022.04

  -

  2023.03

  副部門長, 日本機械学会マイクロ・ナノ工学部門

• 2020.04

  -

  2021.03

  アセアン工学系高等教育ネットワークプロジェクト・フェーズ４分野幹事大学委員会委員, 独立行政法人　国際協力機構

• 2018.04

  -

  2019.12

  実行委員長, 日本機械学会マイクロ・ナノ工学部門　第９回マイクロ・ナノ工学シンポジウム

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