KEIO RESEARCHERS INFORMATION SYSTEM

Profile 【 Display / hide 】

Profile 【 Display / hide 】

• Our group will adopt both experimental and theoretical approaches to connect the physical properties of novel soft materials (or soft matter) with their underlying chemical structures (ranging from atomic-, through nano-, to micron-scales) as well as their industrial applications (e.g. nanomaterials, biomaterials, eco-friendly materials). Our primary research targets are polymers, and the key concepts of our research projects include "multi-scale structures", "self-assembly", "functionalization", "gels", and "composites".

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1994.04

  -

  2004.12

  Bridgestone Corporation

• 2002.09

  -

  2002.12

  Research and Postdoctoral Fellow (Univ of Cambridge, Cavendish Laboratory)

• 2003.01

  -

  2005.03

  Postdoctoral Fellow (Univ of California, Santa Barbara)

• 2005.04

  -

  2008.03

  Assistant Professor, Keio University

• 2007.04

  -

  2009.03

  機械工学科2年生クラス担任

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1990.04

  -

  1994.03

  The University of Tokyo, Faculty of Engineering, Department of Applied Physics

  University, Graduated

• 1999.10

  -

  2002.09

  University of Cambridge, Graduate School, Department of Physics (Cavendish Laboratory)

  United Kingdom, Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• PhD, University of Cambridge, Coursework, 2002.09

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Mechanics of materials and materials (Machine Material/Material Mechanics)

• Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

• Nanotechnology/Materials / Composite materials and interfaces

• Natural Science / Biophysics, chemical physics and soft matter physics

• Life Science / Biomedical engineering

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Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Eco-materials

• Gels

• Composites

• Soft materials

• ナノ構造

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Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• ソフトマテリアル・バイオマテリアル・エコマテリアル・ナノマテリアルの微細構造、表面、物性、力学物性、粘弾性、複合化、高機能化とその実用化検討, 

  2005.04

  -

  Present

Books 【 Display / hide 】

Books 【 Display / hide 】

• シンジオタクチックポリプロピレン(sPP)多孔質材料の力学物性（次世代ポリオレフィン総合研究会, Vol.15）

  前田知貴，堀田篤, 三恵社, 2022.12

• シンジオタクチックポリプロピレン（sPP）乾燥ゲルの構造と吸油性（次世代ポリオレフィン総合研究，Vol.14）

  前田知貴，堀田篤, 三恵社, 2021.12,  Page： pp.29-33

• Polymer nanofabrication and plasma processing

  Maeda T., Endo F., Tsuji K., Hotta A., Handbook of Modern Coating Technologies: Fabrication Methods and Functional Properties, 2021.01

  　View Summary

  Nanofabricated polymers are extremely useful due to their high functionalities caused by the inherent multiscale structures of the nanostructured polymers. Nanostructured polymers for biocoatings can be classified into zero-dimensional (0D) polymeric nanoparticles, 1D polymeric nanofibers, and 2D polymeric nanosheets. The nanostructured polymers with such different dimensions were most often fabricated by emulsion polymerization, electrospinning, and spin coating. To add a desirable and advanced functionality to the targeted nanostructured polymers, surface modifications of the polymers can be highly advantageous. The surface modifications such as plasma etching, plasma-induced cross-linking, plasma polymerization, and chemical vapor deposition can effectively modify the surface characteristics of the nanofabricated polymers, leading to the enhancement of the bulk physical properties of the polymers. In this chapter, the fabrication methods of such nanostructured polymers are reviewed. In addition, several successful cases of well-controlled surface conditions of polymers by plasma processing are introduced.

  • Access to Document (DOI)

• 樹脂/繊維複合材料の界面制御、成形加工と評価

  犬飼駿也，黒川成貴，堀田篤, 技術情報協会, 2018.01

  Scope: 416-423 長繊維セルロースナノファイバーを複合したPVAの力学物性

• 生体吸収性材料の開発と安全性評価

  北川みどり，谷本啓示，前田知貴，堀田篤, 技術情報協会, 2017.12

  Scope: 45-52 ポリエチレングリコールをベースとしたナノコンポジットハイドロゲルの温度応答性と分解挙動

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Development of a Water-Soluble Filter for Potential Use in the Toxicity Evaluation of Ambient Particulate Matter

  Yang L., Nishita-Hara C., Shiraishi M., Tsubakida K., Shibata Y., Jing W., Li D., Yoshimura K., Kurokawa N., Hotta A., Okuda T.

  Aerosol and Air Quality Research 26 ( 1 )  2026.01

  ISSN  16808584

  　View Summary

  Assessment of the toxicity of insoluble particulate matter (PM) in the atmosphere is crucially important. However, because of challenges associated with extracting insoluble PM from filters, the toxicity of insoluble PM remains largely uncharacterized. For this study, the water-soluble filter made of poly (vinyl alcohol) (PVA) was developed with high particle collection efficiency, durability, and weather resistance, which are necessary for ambient PM sampling. The PVA filter is water-soluble under certain conditions, allowing for the recovery of insoluble PM, which can be exposed directly to cells or animals for toxicological studies. The PVA filter was made from PVA nanofibers using the electrospinning (ES) method. Its durability and weather resistance were comparable to those of polytetrafluoroethylene (PTFE) and quartz fiber (QF) filters, and were superior to those of commercially available gelatin filters. The PVA filter particle collection efficiency was evaluated by comparing concentrations of inorganic elements (Mg, Al, Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu and Zn) and water-soluble ionic components (Na⁺, NH<inf>4</inf>⁺, K⁺, Mg²⁺, Ca²⁺, Cl⁻, NO<inf>3</inf>⁻, and SO<inf>4</inf>²⁻) in the PVA filter-collected ambient PM with those in the PTFE filter-collected PM. The concentrations of almost all measured components in the PVA filter-collected PM were comparable to those in the PTFE filter-collected PM. When the PVA filter dissolved in cell culture medium was exposed to cells, no significant difference was found in cell viability compared to a blank solution containing only culture medium, suggesting that the PVA filter has potential use for cell exposure experiments.

  • Access to Document (DOI)

• Endothelial cell adhesion and proliferation on wrinkled diamond-like carbon films on grooved PDMS substrates

  Nagashima S., Hasebe T., Hotta A., Suzuki T.

  Rsc Applied Interfaces  2026

  　View Summary

  Controlling the adhesion and proliferation of endothelial cells is essential for the development of functional vascular materials. In this study, we show that wrinkled diamond-like carbon (DLC) films formed on grooved PDMS substrates regulate endothelial cell alignment and proliferation through combined micro- and nanoscale topographical cues. Human umbilical vein endothelial cells cultured on these hierarchical patterns exhibited directional elongation along the grooves, while their lamellipodia and filopodia preferentially adhered to the wrinkle crests. Enzymatic assays confirmed sustained viability and proliferation across different wrinkle dimensions. These results demonstrate that hierarchical micro-/nanoscale topographies on DLC-coated PDMS substrates can effectively modulate endothelial cell behavior, offering promise for vascular tissue engineering.

  • Access to Document (DOI)

• Fabrication and structural analyses of electrospun syndiotactic propylene-ethylene copolymer nanofibers

  Endo F., Di Girolamo R., Talarico G., Scoti M., Kurokawa N., Hotta A.

  Polymer 337 2025.10

  ISSN  00323861

  　View Summary

  Fabrication and structural characterization of syndiotactic propylene-ethylene (sPPEt) copolymer nanofibers were conducted. When using a mixture of methylcyclohexane/DMF/acetone (8:1:1 (wt/wt)) as a solvent, semi-crystalline sPPEt copolymers with ethylene compositions ranging from 1.9 to 11.8 mol% were successfully fabricated into nanofibers via electrospinning. Copolymerization of sPP with ethylene significantly promoted the formation of thinner and smoother nanofibers by suppressing gelation of the spinning solution, thereby enhancing the electrospinnability of the sPP-based copolymer. FTIR and X-ray structural analyses on sPPEt nanofiber membranes revealed that the electrostatic stretching force during the electrospinning process led to a larger proportion of syndiotactic propylene units in the trans-planar conformation and the resulting formation of mesomorphic form crystals, similar to what has been observed during mechanical stretching and subsequent relaxation.

  • Access to Document (DOI)

• Tunable wrinkles in diamond-like carbon films on PDMS substrates

  Nagashima S., Hasebe T., Hotta A., Suzuki T.

  Diamond and Related Materials 151 2025.01

  ISSN  09259635

  　View Summary

  Diamond-like carbon (DLC) films are widely used in engineering applications owing to their excellent mechanical, optical, and biological properties. However, the simple deposition of a DLC film on a soft polymer, including poly(dimethylsiloxane) (PDMS), results in a coarsened surface composed of instability-induced hierarchical wrinkles with limited ability to adjust the dimensions. Overcoming this issue would help create fabrication opportunities for functional surfaces. Here, we demonstrate the controlled formation of wrinkles with tunable wavelengths and amplitudes on the surface of DLC-coated PDMS substrates. Pre-treatment of the substrates with Ar plasma prior to film deposition allows for the formation of wrinkles without structural hierarchy. The wavelength and amplitude can be controlled by adjusting the duration of the plasma treatment while maintaining the film thickness constant. The static contact angles of water droplets on the wrinkled surfaces remain nearly constant regardless of the wavelength of the wrinkles. These tunable wrinkles in DLC films on PDMS substrates have potential engineering applications, including cell scaffolds.

  • Access to Document (DOI)

• Application of low-birefringence polystyrene in high-resolution imaging-lens systems

  Tamura M., Kurokawa N., Hotta A.

  Optical Review 31 ( 4 ) 430 - 439 2024.08

  ISSN  13406000

  　View Summary

  Polystyrene (PS) has not been much used as an optical material due to the considerably high birefringence of PS. For the extensive use of PS in the imaging-lens systems, lower birefringence should be attained for the enhancement of the resolution. Previously, we have developed PS with extremely low birefringence (LB-PS) even when the molecular chain orientation of PS occurred. It indicates that PS may now become an effective material with excellent properties for optical lenses. In this paper, we compared the birefringence of our developed LB-PS with ones of commercial optical polymers that are most commonly utilized in imaging-lens systems. It was confirmed that the birefringence of LB-PS was comparable or even better than that of the commercial ones with high resolution. By designing an imaging-lens system, it was also confirmed that employing PS with the Abbe number of 31.5 could be highly effective in compensating for chromatic aberration as well as obtaining high optical resolution. Moreover, the resolution performance of several lens systems was calculated, analyzed, and compared by considering the birefringence of cyclo-olefin polymer (COP), normal PS, and LB-PS. It was found that LB-PS could maintain high resolution, while normal PS with high birefringence exhibited significant decrease in resolution. It was also found that LB-PS generated higher resolution than COP. All these results revealed that LB-PS could be an excellent optical material to compensate for the chromatic aberration of lens systems, leading to the enhancement of the actual resolution performance. It was, therefore, expected that LB-PS could contribute to improving the resolution performance of smartphone cameras and security cameras.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Nanofiber fabrication made of super engineering plastics with excellent thermal and mechanical properties

  Hotta, Atsushi

  科学研究費補助金研究成果報告書 2023

• Fabrication of antithrombogenic solid poly(2-methoxyethyl acrylate)

  Hotta, Atsushi

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2022

• Fabrication of thermoplastic, remoldable, and mechanically-tough composite hydrogels

  Hotta, Atsushi

  科学研究費補助金研究成果報告書 2021

• Fabrication of antithrombogenic solid poly(2-methoxyethyl acrylate)

  Hotta, Atsushi

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• Fabrication of antithrombogenic solid poly(2-methoxyethyl acrylate)

  Hotta, Atsushi

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2020

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Correction to: Development of a Water-Soluble Filter for Potential Use in the Toxicity Evaluation of Ambient Particulate Matter (Aerosol and Air Quality Research, (2026), 26, 1, (6), 10.1007/s44408-025-00082-2)

  Yang L., Nishita-Hara C., Shiraishi M., Tsubakida K., Shibata Y., Jing W., Li D., Yoshimura K., Kurokawa N., Hotta A., Okuda T.

  Aerosol and Air Quality Research 26 ( 5 )  2026.05

  ISSN  16808584

  　View Summary

  In the originally published version of this article, an incorrect version of Figure 4 was included due to an error during the final submission process. Figure 4 has been replaced with the correct version, as shown below. The original article has been corrected accordingly. This correction does not affect the results, discussion, or conclusions of the article. The authors apologize for any inconvenience caused. The original article has been corrected. Correct Fig. 4: (Figure presented.) Concentrations and relative compositions of elements measured using EDXRF in the ambient PM collected using the PVA and PTFE filters. Elements are listed in descending order of concentration

  • Access to Document (DOI)

• 炭素材料が開く新世代医療機器の開発

  長谷部光泉，松本知博，堀田篤，鈴木哲也

  New Diamond (ニューダイヤモンドフォーラム)  31 ( 117 ) 5 - 10 2015.04

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Pdナノ粒子を含有したスーパーエンプラナノファイバの作製

  朝倉和輝，堀田篤

  [Domestic presentation]  日本機械学会 関東学生会 第65回学生員卒業研究発表講演会 (日本大学 理工学部 駿河台キャンパス) , 

  2026.03

  , 

  Oral presentation (general), 日本機械学会

• 芳香族ジスルフィド結合を有するエラストマの合成とその力学物性および室温自己修復性

  澁谷沙央梨，堀田篤

  [Domestic presentation]  日本機械学会 関東学生会 第65回学生員卒業研究発表講演会 (日本大学 理工学部 駿河台キャンパス) , 

  2026.03

  , 

  Oral presentation (general), 日本機械学会

• 慢性疼痛治療に用いる生分解性マイクロスフィアの作製と粒径制御

  佐々木一弥，堀田篤

  [Domestic presentation]  日本機械学会 関東学生会 第65回学生員卒業研究発表講演会 (日本大学 理工学部 駿河台キャンパス) , 

  2026.03

  , 

  Oral presentation (general), 日本機械学会

• ヨウ素化合物の分子修飾量の違いによるポリグリセロールのX線視認性および生分解性

  久米里英，堀田篤

  [Domestic presentation]  日本機械学会 関東学生会 第65回学生員卒業研究発表講演会 (日本大学 理工学部 駿河台キャンパス) , 

  2026.03

  , 

  Oral presentation (general), 日本機械学会

• ポリ乳酸（PLA）ゲルの急速冷却作製とその溶媒交換による高強度化

  井田大翔，堀田篤

  [Domestic presentation]  日本機械学会 関東学生会 第65回学生員卒業研究発表講演会 (日本大学 理工学部 駿河台キャンパス) , 

  2026.03

  , 

  Oral presentation (general), 日本機械学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• ナノファイバーとナノ粒子の選択的表面配置による機能多様化ナノ複合材料の開発

  2026.04

  -

  2031.03

  基盤研究(A), Principal investigator

• Development of High-Performance Sustainable Polymers with Reversible Crosslinking via Diverse Intermolecular Interactions

  2025.06

  -

  2031.03

  挑戦的研究（開拓）, Principal investigator

• 熱可逆性を有する含水率99%以上の高強度ダブルネットワークハイドロゲルの創製

  2019.06

  -

  2022.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

• 高耐熱・高強度スーパーエンプラナノファイバーを作る

  2019.04

  -

  2024.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

• ポリマーの熱可塑性・形状記憶性・自己修復性の基礎研究

  2018.04

  -

  Present

  Commissioned ｒesearch, No Setting

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Works 【 Display / hide 】

Works 【 Display / hide 】

• 血管再狭窄 長期防止に道 薬剤溶出ステント 被覆技術開発 血液付着せず内皮化増進

  長谷部光泉、鈴木哲也、堀田篤

  日刊工業新聞 朝刊21面, 

  2016.12

  -

  Present

  , 

  Other

  　View Details

  東海大学医学部の長谷部光泉教授と慶応義塾先端科学技術研究センターの鈴木哲也所長、慶応義塾大学理工学部の堀田篤教授らは、内皮細胞の増殖を促す薬剤溶出ステント用のコーティング技術を開発した。ステントへの血液成分の付着しにくさと、内皮細胞への覆われやすさを両立させた。患者の血管の再狭窄（きょうさく）を長期的に防げる可能性がある。新技術では、まずリン脂質ポリマー（ＭＰＣ）で表面を覆い、その上にダイヤモンド・ライク・カーボン（ＤＬＣ）を成膜する。

Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• CATHETER EMBOLIZATION TRAINING METHOD, TRAINING KIT, AND TRAINING SYSTEM

  Date applied： PCT/JP2025/014557  2025.04 

  Date announced： WO/2025/216327  2025.10 

  Patent

• 管塞栓のトレーニング方法、トレーニングキット、及びトレーニングシス テム

  Date applied： 2024-64343  2024.04 

  Patent, Joint

• RADIOPAQUE BIODEGRADABLE POLYMER AND METHOD FOR PRODUCING THE SAME

  Date applied： 2023006882  2023.01 

  Date announced： 2023126141  2023.09 

  Patent, Joint

• 放射線不透過性生分解性ポリマー及びその製造方法

  Date applied： 特願2022-97853  2022.06 

  Patent, Joint

• 低複屈折光学材用組成物

  Date applied： 特願2022-47162  2022.03 

  Patent, Joint

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Best Presentation Award

  朝倉和輝，堀田篤, 2026.03, The Japan Society of Mechanical Engineers, Pd ナノ粒子を含有したスーパーエンプラナノファイバの作製

  Type of Award： Award from Japanese society, conference, symposium, etc.

• Best Presentation Award

  澁谷沙央梨，堀田篤, 2026.03, The Japan Society of Mechanical Engineers, 芳香族ジスルフィド結合を有するエラストマの合成とその力学物性および室温自己修復性

  Type of Award： Award from Japanese society, conference, symposium, etc.

• Best Presentation Award

  久米里英，堀田篤, 2026.03, The Japan Society of Mechanical Engineers, ヨウ素化合物の分子修飾量の違いによるポリグリセロ―ルアジペートのX線視認性および生分解性

  Type of Award： Award from Japanese society, conference, symposium, etc.

• Best Presentation Award

  井田大翔，堀田篤, 2026.03, The Japan Society of Mechanical Engineers, ポリ乳酸（PLA）ゲルの急速冷却作製とその溶媒交換による高強度化

  Type of Award： Award from Japanese society, conference, symposium, etc.

• Best Presentation Award

  井田大翔，堀田篤, 2026.02, 慶應義塾大学　理工学部　機械工学科, ポリ乳酸マクロポーラスゲルの溶媒交換と多孔質体形成

  Type of Award： Keio commendation etc.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• MECHANICAL ENGINEERING PRACTICAL RESEARCH A

  2026

• INDEPENDENT STUDY ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS

  2026

• PHYSICS A

  2026

• GRADUATE RESEARCH ON CHEMISTRY, LIFE SCIENCE, AND INFORMATICS 1

  2026

• GRADUATE RESEARCH ON ENGINEERING AND DESIGN 2

  2026

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 物理学Ａ

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Within own ｆaculty, 200people

• 開放環境科学特別研究第2

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

• 開放環境科学特別研究第１

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

• 開放環境科学課題研究

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

• 卒業研究

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• ヨウ素学会, 

  2025.04

  -

  Present

• 日本ポリオレフィン総合研究会, 

  2013.04

  -

  Present

• Society of Polyolefin Science & Industry, Japan, 

  2009.04

  -

  Present

• American Chemical Society, 

  2005.09

  -

  Present

• Biophysical Society, 

  2005.09

  -

  Present

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2016.04

  -

  2017.03

  科学研究費補助金・第2段審査・審査第一部会工学小委員会・委員, 日本学術振興会

• 2014.04

  -

  Present

  日本機械学会広報・情報部会委員, 日本機械学会

• 2013

  -

  2015

  科学研究費補助金　第1段審査（書面審査）委員, 日本学術振興会

• 2012.04

  -

  Present

  日本機械学会校閲委員, 日本機械学会

• 2011.09

  -

  Present

  Editorial Advisory Board, Journal of Applied Polymer Science

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