Details of a Researcher - Hotta, Atsushi

Hotta, Atsushi

写真a

Affiliation: Faculty of Science and Technology, Department of Mechanical Engineering （Yagami）

Position: Professor

E-mail Address

Related Websites

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Our group will take both experimental and theoretical approaches to link the physical properties of novel soft materials with their underlying chemical structures (ranging from atomic-, through nano-, to micron-scales) as well as their industrial applications (e.g. nanomaterials, biomaterials, eco-friendly materials). Our major research targets will be polymers, and the keywords for our research projects will be "multilayered structures", "self assembly", and "composite".

Career 【 Display / hide 】

1994.04

-

2004.12

Bridgestone Corporation
2002.09

-

2002.12

Research and Postdoctoral Fellow (Univ of Cambridge, Cavendish Laboratory)
2003.01

-

2005.03

Postdoctoral Fellow (Univ of California, Santa Barbara)
2005.04

-

2008.03

Assistant Professor, Keio University
2007.04

-

2009.03

機械工学科2年生クラス担任

Academic Background 【 Display / hide 】

1990.04

-

1994.03

The University of Tokyo, Faculty of Engineering, Department of Applied Physics

University, Graduated
1999.10

-

2002.09

University of Cambridge, Graduate School, Department of Physics (Cavendish Laboratory)

United Kingdom, Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide 】

PhD, University of Cambridge, Coursework, 2002.09

Research Areas 【 Display / hide 】

Materials/Mechanics of materials (Machine Material/Material Mechanics)
Polymer/Textile materials (Polymer/Textile Materials)
Composite materials/Surface and interface engineering
Composite materials/Surface and interface engineering (Composite Materials/Physical Properties)
Biological physics/Chemical physics/Soft matter physics

Research Keywords 【 Display / hide 】

Eco-materials
Gels
Composites
Soft materials
ナノ構造

Research Themes 【 Display / hide 】

ソフトマテリアル・バイオマテリアル・エコマテリアル・ナノマテリアルの微細構造、表面、物性、力学物性、粘弾性、複合化、高機能化とその実用化検討,

2005.04

-

Present

Books 【 Display / hide 】

樹脂/繊維複合材料の界面制御、成形加工と評価

犬飼駿也，黒川成貴，堀田篤, 技術情報協会, 2018.01

Scope: 416-423 長繊維セルロースナノファイバーを複合したPVAの力学物性
生体吸収性材料の開発と安全性評価

北川みどり，谷本啓示，前田知貴，堀田篤, 技術情報協会, 2017.12

Scope: 45-52 ポリエチレングリコールをベースとしたナノコンポジットハイドロゲルの温度応答性と分解挙動
次世代ポリオレフィン総合研究，Vol. 11、有機シラン中間層の導入によるダイヤモンドライクカーボン/ポリオレフィン複合材料のガスバリア性向上

前田知貴，堀田篤, 三恵社, 2017.11

Scope: 108-112
NANOSTRUCTURES FOR NOVEL THERAPY; Chapter 8: Electrospinning and surface modification methods for functionalized cell scaffolds

N. Kurokawa, F. Endo, T. Maeda, A. Hotta, Elsevier, 2017.02

Scope: Chapter 8
次世代ポリオレフィン総合研究，Vol. 10，ポリオレフィン材料の高ガスバリア化にむけたダイヤモンドライクカーボン（DLC）薄膜コーティングの開発

青木拓，堀田篤, 三恵社, 2016.11

Scope: 89-94

Papers 【 Display / hide 】

Antithrombogenic poly(2-methoxyethyl acrylate) elastomer via triblock copolymerization with poly(methyl methacrylate)

Kurokawa N., Endo F., Bito K., Maeda T., Hotta A.

Polymer （Polymer) 228 2021.07

ISSN 00323861

　View Summary

For the development of blood-contacting biomedical devices, preventing platelet adhesion and avoiding subsequent thrombosis through antithrombogenic surface are vitally important. Poly (2-methoxyethyl acrylate) (PMEA) is a synthetic viscous polymer with an excellent antithrombogenic property, which has already been used as an antithrombogenic coating for biomedical purposes. The PMEA coating, however, can be easily broken due to its liquid-like feature, since the glass transition temperature (Tg) of PMEA is at −25οC. Solidifying PMEA has, therefore, been desperately desired for the improvement of the stability of PMEA coating. Also, once solidified, PMEA could be utilized not only for coating but also for structural materials for medical devices, expanding the application range of PMEA. In this study, PMEA was first solidified by triblock copolymerization with poly (methyl methacrylate) (PMMA) to obtain thermoplastic elastomers with excellent antithrombogenicity. We synthesized PMMA-PMEA-PMMA triblock copolymers with different volume fractions of PMMA (fMMA) by atom transfer radical polymerization (ATRP). The synthesis and the chemical structures of the new triblock copolymers were characterized and confirmed by proton nuclear magnetic resonance (1H NMR) analyses and gel permeation chromatography (GPC). The synthesized elastomeric triblocks were then compression-molded at 180οC to obtain solid transparent films. The tensile property was measured and the drastic change from the soft-elastomer phase to the hard-plastic phase was clearly observed by varying fMMA. It was found that the new triblocks possessed significantly higher tensile strengths than the other solidified PMEA by the previous studies. The platelet adhesion test revealed that the number of adherent platelets on the triblocks with fMMA of 0.12 and 0.40 was almost the same as that on pure PMEA, indicating that the synthesized triblocks possessed excellent antithrombogenicity similar to liquid PMEA. Further investigation on hydrated water and microphase-separated structures eventually revealed that the new triblock copolymers with a sufficient amount of intermediate water or with microphase separation on the surface resulted in excellent antithrombogenicity.
- Access to Document (DOI)
Fabrication of Gd-DOTA-functionalized carboxylated nanodiamonds for selective MR imaging (MRI) of the lymphatic system

Yano K., Matsumoto T., Okamoto Y., Kurokawa N., Hasebe T., Hotta A.

Nanotechnology （Nanotechnology) 32 （ 23 ） 2021.06

ISSN 09574484

　View Summary

Magnetic resonance imaging (MRI) contrast agents with the particle diameter of around 3-10 nm hold the potential to be selectively uptaken by lymphatic vessels and be filtered in the kidney for final excretion. However, there are no existing MRI contrast agents based on gadolinium (Gd) complexes within the size of this range, and thus the selective imaging of the lymphatic system has not yet been achieved. In our previous report, we succeeded in fabricating nano-scale MRI contrast agents by complexing ordinary contrast agents (Gd-diethylenetriaminepentaacetic acid (DTPA)) with carboxylated nanodiamond (CND) particles to conquer this problem. However, DTPA has recently been reported to release Gd ions in the course of time, leading to the potential danger of severe side effects in the human body. In this study, we utilized cyclic-chained DOTA as an alternative chelating material for DTPA to fabricate CND-based MRI contrast agents for the selective lymphatic imaging. The newly fabricated contrast agents possessed the diameter ranging from 3 to 10 nm in distilled water and serum, indicating that these particles can be selectively uptaken by lymphatic vessels and effectively filtered in the kidney. Furthermore, the DOTA-applied CND contrast agents exhibited stronger MRI visibility in water and serum compared to DTPA-applied CND contrast agents. These results indicate that DOTA-applied CND contrast agents are promising materials for the selective MR imaging of lymphatic systems.
- Access to Document (DOI)
Degradation of thermoresponsive laponite/PEG-b-PLGA nanocomposite hydrogels controlled by blending PEG-b-PLGA diblock copolymers with different PLGA molecular weights

Maeda T., Kitagawa M., Hotta A.

Polymer Degradation and Stability （Polymer Degradation and Stability) 187 2021.05

ISSN 01413910

　View Summary

The thermoresponsive gelation behavior and the degradation behavior of the nanocomposites consisting of poly(ethylene glycol)-b-poly(lactic acid-co-glycolic acid) (PEG-b-PLGA) diblock copolymers and clay nanoparticles (laponite) (laponite/PEG-b-PLGA nanocomposites) were studied by changing the blend ratio of the PEG-b-PLGA diblock copolymers using different PLGA molecular weights of 800 g/mol and 1600 g/mol: PEG-b-PLGA (1000-800, Diblock0.8k) and PEG-b-PLGA (1000-1600, Diblock1.6k). It was found that each gelation temperature was in the temperature range between 25°C and 37°C, when the PEG-b-PLGA concentration and the laponite concentration were kept at 3–4 wt% and 1 wt%, respectively. The degradation rate at 37°C was found to be effectively regulated by the Diblock1.6k/Diblock0.8k blend ratio (DR). In detail, after 15 days of the degradation experiments, the weight loss was decreased by ∼14% when DR changed from DR=0/100 to DR=100/0. It was, therefore, confirmed that DR was the key parameter to control the degradation behavior of the laponite/blended PEG-b-PLGA nanocomposites.
- Access to Document (DOI)
Gadolinium-Complexed Carboxylated Nanodiamond Particles for Magnetic Resonance Imaging of the Lymphatic System

Yano K., Matsumoto T., Okamoto Y., Bito K., Kurokawa N., Hasebe T., Hotta A.

ACS Applied Nano Materials （ACS Applied Nano Materials) 4 （ 2 ） 1702 - 1711 2021.02

　View Summary

MRI contrast agents with a size of 3-10 nm are considered to be an effective pathway for selective MR lymphatic imaging. In our previous study, we fabricated nanosized MRI contrast agents (Gd-DTPA-ND) with the condensation of nanodiamond (ND) particles and gadolinium chelates (Gd-DTPA). However, these Gd-DTPA-ND particles formed microscale aggregates in distilled water, exceeding the size required for selective lymphatic MR imaging. In this study, carboxylated nanodiamond (CND) particles were utilized as alternative platforms for condensation with gadolinium complexes. The carboxyl groups introduced by oxidation were expected to induce hydrophilicity with a negative charge on the ND surface, resulting in the high dispersity of gadolinium-complexed CND particles. The fabricated Gd-DTPA-CND particles possessed a hydrodynamic diameter of around 4-5 nm without any signs of aggregation in distilled water and human serum. Furthermore, the T1-weighted image of Gd-DTPA-CND particles in distilled water and human serum presented strong contrast, indicating the excellent MRI visibility of the particles. Therefore, the Gd-DTPA-CND particles can become practical MRI contrast agents for the achievement of selective MR imaging of the lymphatic system.
- Access to Document (DOI)
Structures and mechanical properties of electrospun cellulose nanofibers/poly(ε-caprolactone) composites

Taniguchi H., Kurokawa N., Inukai S., Hotta A.

Journal of Applied Polymer Science （Journal of Applied Polymer Science) 137 （ 42 ） 2020.11

ISSN 00218995

　View Summary

© 2020 Wiley Periodicals, Inc. Poly(ε-caprolactone) (PCL) is one of the ecofriendly biodegradable polymers with excellent moldability but with rather low mechanical properties especially for the industrial and biomedical use. In this research, to overcome the problem, the two types of cellulose nanofibers, the cellulose acetate nanofibers (CA-NF) and the cellulose nanofibers (C-NF), were composited into PCL for the enhancement of the mechanical properties of PCL. CA-NF were prepared by electrospinning and converted into C-NF afterward by deacetylation. It was found that the Young's modulus of the CA-NF/PCL composite at the fiber concentration of 35 wt% significantly increased by ~3 times as compared with that of neat PCL, whereas C-NF/PCL of the same fiber concentration also increased by ~4.5 times. It was also found that the Young's moduli of CA-NF/PCL nearly reached the theoretical values calculated by the equation suggested by Tsai, but that the Young's moduli of C-NF/PCL could not reach the theoretical values. It indicates that CA-NF possessed better compatibility with PCL than C-NF, agreeing well with the fracture-surface analyses of the two composites by the scanning electron microscopy.
- Access to Document (DOI)

Papers, etc., Registered in KOARA 【 Display / hide 】

A new anisotropic nanofiber/polymer composite made of different polymers for the AB-different polymer blending

Hotta, Atsushi

科学研究費補助金研究成果報告書 2018
Synthesis of polymer nanofibers and their applications

Hotta, Atsushi

学事振興資金研究成果実績報告書（慶應義塾大学) 2017
A new anisotropic nanofiber/polymer composite made of different polymers for the AB-different polymer blending (Fostering Joint International Research)

Hotta, Atsushi

科学研究費補助金研究成果報告書 2017
Preparation of new functional nanofiber composites by photografting polymerizations

Hotta, Atsushi

科学研究費補助金研究成果報告書 2014
Fabrication of a new nanocomposite by the electrospinning/electrospray method

Hotta, Atsushi

科学研究費補助金研究成果報告書 2014

Reviews, Commentaries, etc. 【 Display / hide 】

炭素材料が開く新世代医療機器の開発

長谷部光泉，松本知博，堀田篤，鈴木哲也

New Diamond (ニューダイヤモンドフォーラム) 31 ( 117 ) 5 - 10 2015.04

Introduction and explanation (scientific journal), Joint Work

Presentations 【 Display / hide 】

Synthesis of PMMA-PMEA-PMMA triblock copolymer and its mechanical and anti-thrombogenic properties

N. Kurokawa, F. Endo, K. Bito, T. Maeda, A. Hotta

日本化学会第98春季年会2018 (日本大学理工学部　船橋キャンパス，千葉) , 2018.03, Oral Presentation(general), 日本化学会
Solidification of poly(2-methoxyethyl aclylate) via block copolymerization with poly(methyl methacrylate) and its properties

N. Kurokawa, F. Endo, K. Bito, T. Maeda, A. Hotta

日本化学会第98春季年会2018 (日本大学理工学部　船橋キャンパス，千葉) , 2018.03, Poster (general), 日本化学会
固体ポリメトキシエチルアクリレートの作製とその力学物性評価

松枝知征，堀田篤

日本機械学会関東支部関東学生会第57回学生員卒業研究発表講演会 (電気通信大学，調布) , 2018.03, Oral Presentation(general), 日本機械学会
X線視認性を有する医療用マイクロビーズの作製と空気プラズマ処理を利用したその表面改質

岡本穣，堀田篤

日本機械学会関東支部関東学生会第57回学生員卒業研究発表講演会 (電気通信大学，調布) , 2018.03, Oral Presentation(general), 日本機械学会
カチオン性のポリスチレンナノ粒子の作製

篠田航希，堀田篤

日本機械学会関東支部関東学生会第57回学生員卒業研究発表講演会 (電気通信大学，調布) , 2018.03, Oral Presentation(general), 日本機械学会

Research Projects of Competitive Funds, etc. 【 Display / hide 】

熱可逆性を有する含水率99%以上の高強度ダブルネットワークハイドロゲルの創製

2019.06

-

2022.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, 堀田　篤, Grant-in-Aid for Challenging Research (Exploratory) , Principal Investigator
高耐熱・高強度スーパーエンプラナノファイバーを作る

2019.04

-

2024.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, 堀田　篤, Grant-in-Aid for Scientific Research (A) , Principal Investigator
ポリマーゲルを用いた人工血栓作製および血管内皮細胞を用いた血管内損傷試験モデル構築

2018.04

-

Present

Joint research, Principal Investigator
ポリマーの熱可塑性・形状記憶性・自己修復性の基礎研究

2018.04

-

2019.03

Commissioned ｒesearch
ナノファイバ複合材料

2018.04

-

2019.03

Commissioned ｒesearch, Principal Investigator

Works 【 Display / hide 】

血管再狭窄長期防止に道薬剤溶出ステント被覆技術開発血液付着せず内皮化増進

長谷部光泉、鈴木哲也、堀田篤

日刊工業新聞朝刊21面,

2016.12

-

Present
,
Other

　View Details

東海大学医学部の長谷部光泉教授と慶応義塾先端科学技術研究センターの鈴木哲也所長、慶応義塾大学理工学部の堀田篤教授らは、内皮細胞の増殖を促す薬剤溶出ステント用のコーティング技術を開発した。ステントへの血液成分の付着しにくさと、内皮細胞への覆われやすさを両立させた。患者の血管の再狭窄（きょうさく）を長期的に防げる可能性がある。新技術では、まずリン脂質ポリマー（ＭＰＣ）で表面を覆い、その上にダイヤモンド・ライク・カーボン（ＤＬＣ）を成膜する。

Intellectual Property Rights, etc. 【 Display / hide 】

固体（ポリ（2-メトキシエチルアクリレート）

Application No.：特願2018-35438 2018.02

Patent, Single, National application
被覆プラスチック成形体及びその製造方法

Application No.：特願2017-249628 2018.01

Patent, Single, National application
樹脂容器及び樹脂フィルム

Application No.：特願2014-021475 2014.02

Patent, Single, National application
成形体

Application No.：特願2013-234700 2013.11

Patent, Single, National application
蒸着用プラスチック成形体、ガスバリア性プラスチック成形体及びそれらの製造方法

Application No.：特許願　2012-270636 2012.12

Patent, Single, National application

Awards 【 Display / hide 】

関東学生会第57回学生員卒業研究発表講演会ベストプレゼンテーション賞

松枝知征，堀田篤, 2018.03, 機械学会, 固体ポリメトキシエチルアクリレートの作製とその力学物性評価

Type of Award： Awards of National Conference, Council and Symposium
関東学生会第57回学生員卒業研究発表講演会ベストプレゼンテーション賞

岡本穣，堀田篤, 2018.03, 機械学会, X線視認性を有する医療用マイクロビーズの作製と空気プラズマ処理を利用したその表面改質

Type of Award： Awards of National Conference, Council and Symposium
関東学生会第57回学生員卒業研究発表講演会ベストプレゼンテーション賞

牧良洋，堀田篤, 2018.03, 機械学会, 有機シランおよびDLCをコーティングしたポリプロピレンの酸素バリア性

Type of Award： Awards of National Conference, Council and Symposium
関東学生会第56回学生員卒業研究発表講演会ベストプレゼンテーション賞

市村弘毅，堀田篤, 2017.03, 機械学会, 光グラフト重合により表面改質をしたナノファイバとポリスチレンの複合材料とその力学物性

Type of Award： Awards of National Conference, Council and Symposium
第30回ダイヤモンドシンポジウム最優秀賞

中山正光, 長谷部光泉, 前川駿人, 尾藤健太, 大和裕哉, 中野裕揮, 田中美夏, 白幡智史, 林敏彦, 嶺貴彦, 松本知博, 堀田篤, 鈴木哲也, 2016.11, 高分子学会, フッ素添加DLCの抗血栓性メカニズムの解明: 血漿タンパク質吸着量および吸着形態の評価

Type of Award： Awards of National Conference, Council and Symposium

Courses Taught 【 Display / hide 】

PHYSICS A

2021
MATERIAL DESIGN

2021
LABORATORIES IN SCIENCE AND TECHNOLOGY

2021
INTRODUCTION TO MATERIALS SCIENCE

2021
INDEPENDENT STUDY ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS

2021

Courses Previously Taught 【 Display / hide 】

物理学Ａ

Keio University, 2018, Spring Semester, General education subject, Lecture, Within own ｆaculty, 200people
工場見学

Keio University, 2018, Spring Semester, Major subject, Within own ｆaculty, 19people
環境エネルギー科学特論第１

Keio University, 2018, Spring Semester, Major subject, Lecture, Within own ｆaculty, 60people
機械加工学の基礎

Keio University, 2018, Spring Semester, Major subject, Lecture, Lecturer outside of Keio, 150people
機械工学実験

Keio University, 2018, Spring Semester, Major subject, Laboratory work/practical work/exercise, Within own ｆaculty

Memberships in Academic Societies 【 Display / hide 】

日本ポリオレフィン総合研究会,

2013.04

-

Present
Society of Polyolefin Science & Industry, Japan,

2009.04

-

Present
American Chemical Society,

2005.09

-

Present
Biophysical Society,

2005.09

-

Present
日本機械学会,

2005.04

-

Present

Committee Experiences 【 Display / hide 】

2016.04

-

2017.03

科学研究費補助金・第2段審査・審査第一部会工学小委員会・委員, 日本学術振興会
2014.04

-

Present

日本機械学会広報・情報部会委員, 日本機械学会
2013

-

2015

科学研究費補助金　第1段審査（書面審査）委員, 日本学術振興会
2012.04

-

Present

日本機械学会校閲委員, 日本機械学会
2011.09

-

Present

Editorial Advisory Board, Journal of Applied Polymer Science