Hotta, Atsushi

写真a

Affiliation

Faculty of Science and Technology, Department of Mechanical Engineering (Yagami)

Position

Professor

Related Websites

External Links
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Profile 【 Display / hide 】

  • Our group will take both experimental and theoretical approaches to link the physical properties of novel soft materials with their underlying chemical structures (ranging from atomic-, through nano-, to micron-scales) as well as their industrial applications (e.g. nanomaterials, biomaterials, eco-friendly materials). Our major research targets will be polymers, and the keywords for our research projects will be "multilayered structures", "self assembly", and "composite".

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Career 【 Display / hide 】

  • 1994.04
    -
    2004.12

    Bridgestone Corporation

  • 2002.09
    -
    2002.12

    Research and Postdoctoral Fellow (Univ of Cambridge, Cavendish Laboratory)

  • 2003.01
    -
    2005.03

    Postdoctoral Fellow (Univ of California, Santa Barbara)

  • 2005.04
    -
    2008.03

    Assistant Professor, Keio University

  • 2007.04
    -
    2009.03

    機械工学科2年生クラス担任

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Academic Background 【 Display / hide 】

  • 1990.04
    -
    1994.03

    The University of Tokyo, Faculty of Engineering, Department of Applied Physics

    University, Graduated

  • 1999.10
    -
    2002.09

    University of Cambridge, Graduate School, Department of Physics (Cavendish Laboratory)

    United Kingdom, Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

  • PhD, University of Cambridge, Coursework, 2002.09

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Research Areas 【 Display / hide 】

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Mechanics of materials and materials (Machine Material/Material Mechanics)

  • Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

  • Nanotechnology/Materials / Composite materials and interfaces

  • Natural Science / Biophysics, chemical physics and soft matter physics

  • Life Science / Biomedical engineering

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Research Keywords 【 Display / hide 】

  • Eco-materials

  • Gels

  • Composites

  • Soft materials

  • ナノ構造

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Research Themes 【 Display / hide 】

  • ソフトマテリアル・バイオマテリアル・エコマテリアル・ナノマテリアルの微細構造、表面、物性、力学物性、粘弾性、複合化、高機能化とその実用化検討, 

    2005.04
    -
    Present

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Books 【 Display / hide 】

  • シンジオタクチックポリプロピレン(sPP)多孔質材料の力学物性（次世代ポリオレフィン総合研究会, Vol.15）

    前田知貴，堀田篤, 三恵社, 2022.12

  • シンジオタクチックポリプロピレン（sPP）乾燥ゲルの構造と吸油性（次世代ポリオレフィン総合研究，Vol.14）

    前田知貴，堀田篤, 三恵社, 2021.12,  Page： pp.29-33

  • Polymer nanofabrication and plasma processing

    Maeda T., Endo F., Tsuji K., Hotta A., Handbook of Modern Coating Technologies: Fabrication Methods and Functional Properties, 2021.01

    　View Summary

    Nanofabricated polymers are extremely useful due to their high functionalities caused by the inherent multiscale structures of the nanostructured polymers. Nanostructured polymers for biocoatings can be classified into zero-dimensional (0D) polymeric nanoparticles, 1D polymeric nanofibers, and 2D polymeric nanosheets. The nanostructured polymers with such different dimensions were most often fabricated by emulsion polymerization, electrospinning, and spin coating. To add a desirable and advanced functionality to the targeted nanostructured polymers, surface modifications of the polymers can be highly advantageous. The surface modifications such as plasma etching, plasma-induced cross-linking, plasma polymerization, and chemical vapor deposition can effectively modify the surface characteristics of the nanofabricated polymers, leading to the enhancement of the bulk physical properties of the polymers. In this chapter, the fabrication methods of such nanostructured polymers are reviewed. In addition, several successful cases of well-controlled surface conditions of polymers by plasma processing are introduced.

  • 樹脂/繊維複合材料の界面制御、成形加工と評価

    犬飼駿也，黒川成貴，堀田篤, 技術情報協会, 2018.01

    Scope: 416-423 長繊維セルロースナノファイバーを複合したPVAの力学物性

  • 生体吸収性材料の開発と安全性評価

    北川みどり，谷本啓示，前田知貴，堀田篤, 技術情報協会, 2017.12

    Scope: 45-52 ポリエチレングリコールをベースとしたナノコンポジットハイドロゲルの温度応答性と分解挙動

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Papers 【 Display / hide 】

  • Thermally Reversible Gel-Sol Transition of Hydrogels via Dissociation and Association of an Artificial Protein Nanocage

    Nasu E., Kawakami N., Takamura S., Hotta A., Arai R., Miyamoto K.

    Biomacromolecules (Biomacromolecules)  25 ( 4 ) 2358 - 2366 2024.04

    ISSN  15257797

    　View Summary

    Oligomeric protein nanocages often disassemble into their subunits and reassemble by external stimuli. Thus, using these nanocages as cross-linkers for hydrogel network structures is a promising approach to allow hydrogels to undergo stimuli-responsive gel-sol transitions or self-healing. Here, we report hydrogels that show a reversible gel-sol transition resulting from the heat-induced dissociation and reassociation of protein nanocages. The hydrogel contained the 60-mer artificial protein nanocage, TIP60, as a supramolecular cross-linker for polyethylene glycol network structures. The hydrogel showed a gel-to-sol transition upon heating at a temperature above the melting point of TIP60 and immediately returned to a gel state upon cooling to room temperature. During the heating and cooling treatment of the hydrogel, small-angle X-ray scattering analysis suggested the dissociation and reassociation of TIP60. Furthermore, we demonstrated redox-responsive cargo release from TIP60 in the hydrogel. These results showed the potential of TIP60 as a component of multi-stimuli-responsive hydrogels.

  • Contact-Killing Antibacterial Polystyrene Polymerized Using a Quaternized Cationic Initiator

    Jitsuhiro A., Maeda T., Ogawa A., Yamada S., Konoeda Y., Maruyama H., Endo F., Kitagawa M., Tanimoto K., Hotta A., Tsuji T.

    ACS Omega (ACS Omega)  9 ( 8 ) 9803 - 9812 2024.02

    　View Summary

    Contact-killing antibacterial materials are attracting attention owing to their ability for sustained antibacterial activity. However, contact-killing antibacterial polystyrene (PS) has not been extensively studied because its chemically stable structure impedes chemical modification. In this study, we developed an antibacterial PS sheet with a contact-killing surface using PS synthesized from 2,2′-azobis-[2-(1,3-dimethyl-4,5-dihydro-1H-imi-dazol-3-ium-2-yl)]propane triflate (ADIP) as a radical initiator with cationic moieties. The PS sheet synthesized with ADIP (ADIP-PS) exhibited antibacterial activity in contrast to PS synthesized with other azo radical initiators. Surface ζ-potential measurements revealed that only ADIP-PS had a cationic surface, which contributed to its contact-killing antibacterial activity. The ADIP-PS sheets also exhibited antibacterial activity after washing. In contrast, PS sheets containing silver, a typical leachable antibacterial agent, lost all antibacterial activity after the same washing treatment. The antibacterial ADIP-PS sheet demonstrated strong broad-spectrum activity against both Gram-positive and Gram-negative bacteria, including drug-resistant bacteria. Cytotoxicity tests using L929 cells showed that the ADIP-PS sheets were noncytotoxic. This contact-killing antibacterial PS synthesized with ADIP thus demonstrated good prospects as an easily producible antimicrobial material.

  • Blending Bottlebrush Polymers for Compensation of Orientation Birefringence of Polystyrene for Use as an Optical Polymer

    Tamura M., Kurokawa N., Hotta A.

    ACS Applied Polymer Materials (ACS Applied Polymer Materials)  5 ( 12 ) 10245 - 10255 2023.12

    　View Summary

    For optical applications, including lenses, widely used polystyrene (PS) has not received much attention due to its considerably high birefringence. In this study, an efficient method was introduced to compensate for the orientation birefringence of PS through bottlebrush polymers with well-controlled PS graft chains (PS-BBP). PS-BBP were synthesized by ring-opening metathesis polymerization of norbornene-terminated PS macromonomers produced via atom transfer radical polymerization. Blend-film samples were then prepared by mixing linear PS and PS-BBP. One of the blend samples with a specific ratio of linear PS to PS-BBP (30:70) demonstrated extremely low orientation birefringence of |Δn| ∼3.9 × 10-4 even under 120% strain. In addition, the blend samples preserved almost the same refractive indices as linear PS, possessing the transparency required for optical polymers across the visible-wavelength range. The obtained PS blend could be utilized as an optical material with excellent optical properties.

  • Multifunctionality of Iodinated Halogen-Bonded Polymer: Biodegradability, Radiopacity, Elasticity, Ductility, and Self-Healing Ability

    Oyama Y., Kurokawa N., Hotta A.

    ACS Biomaterials Science and Engineering (ACS Biomaterials Science and Engineering)  9 ( 11 ) 6094 - 6102 2023.11

    　View Summary

    A polymer with high contents of ester bonds and iodine atoms was synthesized, exhibiting sufficient biodegradability and radioactivity for biomedical applications. The iodine moieties of the synthesized polyester can generate halogen bonding between molecules, which may develop additional functional properties through the bonding. In this study, poly(glycerol adipate) (PGA) was selected and synthesized as a polyester, which was then adequately conjugated with three different types of iodine compounds via the hydroxy groups of PGA. It was found that the iodine compounds could effectively work as donors of halogen bonding. The thermal analysis by differential scanning calorimetry (DSC) revealed that the glass transition temperature increased with the increase in the strength of interactions caused by π-π stacking and halogen bonding, eventually reaching 49.6 °C for PGA with triiodobenzoic groups. An elastomeric PGA with monoiodobenzoic groups was also obtained, exhibiting a high self-healing ability at room temperature because of the reconstruction of halogen bonding. Such multifaceted performance of the synthesized polyester with controllable thermal/mechanical properties was realized by halogen bonding, leading to a promising biomaterial with multifunctionality.

  • Measurements of the Dissociation Heats of Tetrabutylammonium Acetate and Tetrabutylammonium Hydroxide Ionic Semiclathrate Hydrates

    Iwai T., Takamura S., Hotta A., Ohmura R.

    International Journal of Thermophysics (International Journal of Thermophysics)  44 ( 3 )  2023.03

    ISSN  0195928X

    　View Summary

    Ionic semiclathrate hydrates mainly consist of water typically together with tetrabutylammonium and tetrabutylphosphonium salts. Since ionic semiclathrate hydrates have the large dissociation heat under ambient pressure and temperature conditions, various ionic semiclathrate hydrates have been studied as safety and eco-friendly phase change materials. In this study, tetrabutylammonium acetate hydrates and tetrabutylammonium hydroxide hydrates were proposed as thermal energy storage media for air conditioning and cooling lithium-ion batteries. The dissociation heat, which was a significant thermophysical property to design thermal energy storage systems, were measured at various mass fractions. The largest dissociation heats of tetrabutylammonium acetate hydrates and tetrabutylammonium hydroxide hydrates were 212.9 ± 0.9 kJ⋅kg−1 and 200.4 ± 2.2 kJ⋅kg−1. As a result of the comparison of the dissociation heats of tetrabutylammonium acetate hydrates and tetrabutylammonium hydroxide hydrates with those of other ionic semiclathrate hydrates, it was found that tetrabutylammonium acetate hydrates and tetrabutylammonium hydroxide hydrates had the promising thermophysical properties as thermal energy storage media for air conditioning and cooling lithium-ion batteries, respectively.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 炭素材料が開く新世代医療機器の開発

    長谷部光泉，松本知博，堀田篤，鈴木哲也

    New Diamond (ニューダイヤモンドフォーラム)  31 ( 117 ) 5 - 10 2015.04

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • バイオマテリアルに向けた高密度ハロゲン結合を有する多機能性エラストマーの合成

    大山裕也，黒川成貴，堀田篤

    第72回高分子学会年次大会 (Ｇメッセ群馬) , 

    2023.05
    , 

    Poster presentation, 高分子学会

  • ハロゲン結合により自己修復性を有する生分解性・X線視認性エラストマーの合成

    大山裕也，黒川成貴，堀田篤

    第72回高分子学会年次大会 (Ｇメッセ群馬) , 

    2023.05
    , 

    Oral presentation (general), 高分子学会

  • 高弾性な人工水晶体に向けたポリジメチルシロキサン（PDMS）ボトルブラシポリマの開発

    浅野世夏，堀田篤

    日本機械学会第62回学生員卒業研究発表講演会 (web開催) , 

    2023.03
    , 

    Oral presentation (general), 日本機械学会

  • 腸リンパ管造影に向けたヨード化ケシ油脂肪酸エチルエステル胆汁酸ミセルの作製

    半谷隆弥，堀田篤

    日本機械学会第62回学生員卒業研究発表講演会 (web開催) , 

    2023.03
    , 

    Oral presentation (general), 日本機械学会

  • シクロオレフィンコポリマにセルロースナノファイバを複合した高強度透明耐熱材料の作製

    武内裕太郎，堀田篤

    日本機械学会第62回学生員卒業研究発表講演会 (web開催) , 

    2023.03
    , 

    Oral presentation (general), 日本機械学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 熱可逆性を有する含水率99%以上の高強度ダブルネットワークハイドロゲルの創製

    2019.06
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

  • 高耐熱・高強度スーパーエンプラナノファイバーを作る

    2019.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

  • ポリマーゲルを用いた人工血栓作製および血管内皮細胞を用いた血管内損傷試験モデル構築

    2018.04
    -
    Present

    Joint research, Principal investigator

  • ポリマーの熱可塑性・形状記憶性・自己修復性の基礎研究

    2018.04
    -
    2019.03

    Commissioned ｒesearch, No Setting

  • ナノファイバ複合材料

    2018.04
    -
    2019.03

    Commissioned ｒesearch, Principal investigator

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Works 【 Display / hide 】

  • 血管再狭窄 長期防止に道 薬剤溶出ステント 被覆技術開発 血液付着せず内皮化増進

    長谷部光泉、鈴木哲也、堀田篤

    日刊工業新聞 朝刊21面, 

    2016.12
    -
    Present
    , 

    Other

    　View Details

    東海大学医学部の長谷部光泉教授と慶応義塾先端科学技術研究センターの鈴木哲也所長、慶応義塾大学理工学部の堀田篤教授らは、内皮細胞の増殖を促す薬剤溶出ステント用のコーティング技術を開発した。ステントへの血液成分の付着しにくさと、内皮細胞への覆われやすさを両立させた。患者の血管の再狭窄（きょうさく）を長期的に防げる可能性がある。新技術では、まずリン脂質ポリマー（ＭＰＣ）で表面を覆い、その上にダイヤモンド・ライク・カーボン（ＤＬＣ）を成膜する。

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 塞栓材及びその製造方法

    Date applied： 特願 2021-032665  2021.03 

    Patent, Joint

  • 塞栓材およびその製造方法

    Date applied： 特願 2021-008824  2021.01 

    Patent, Joint

  • 抗微生物性樹脂および塗材

    Date applied： 特願 2019-017544, 国際公開番号 WO 2019/208674 A1  2019.10 

    Patent, Joint

  • 化学修飾ナノダイヤモンド粒子，その製造方法，及びそれを用いたＭＲＩ造影剤

    Date applied： 特願2019-41536  2019.09 

    Patent, Joint

  • 固体（ポリ（2-メトキシエチルアクリレート）

    Date applied： 特願2018-35438  2018.02 

    Patent, Single

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Awards 【 Display / hide 】

  • Best Presentation Award

    内田陸登，堀田篤, 2023.03, The Japan Society of Mechanical Engineers, 分子末端にカチオン基を有する透明ポリマ樹脂の作製とその抗菌性

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Presentation Award

    篠田祐樹，堀田篤, 2023.03, The Japan Society of Mechanical Engineers, ポリマ側鎖に官能基を有する生分解性ポリマの有機触媒合成

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Presentation Award

    石塚駿介，堀田篤, 2022.03, The Japan Society of Mechanical Engineers, カチオン基の末端を有する分子量を制御したポリスチレンの抗菌性

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Presentation Award

    高村修平，堀田篤, 2022.03, The Japan Society of Mechanical Engineers, 自然由来のポリメチルカプロラクトンを用いた自己修復性エラストマの作製

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 第54回リバネス研究費　東洋紡　高分子科学賞

    大山裕也, 2022.02, リバネス, 医療応用に向けた，使用用途に応じて機能性を付与できる生分解性ポリマーの合成とその高強度化

    Type of Award： Honored in official journal of a scientific society, scientific journal

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Courses Taught 【 Display / hide 】

  • PHYSICS A

    2025

  • MATERIAL DESIGN

    2025

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2025

  • INTRODUCTION TO MATERIALS SCIENCE

    2025

  • INDEPENDENT STUDY ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS

    2025

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Courses Previously Taught 【 Display / hide 】

  • 物理学Ａ

    Keio University

    2018.04
    -
    2019.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 200people

  • 開放環境科学特別研究第2

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

  • 開放環境科学特別研究第１

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

  • 開放環境科学課題研究

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

  • 卒業研究

    Keio University

    2018.04
    -
    2019.03
    , 

    Full academic year, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

  • 日本ポリオレフィン総合研究会, 

    2013.04
    -
    Present

  • Society of Polyolefin Science & Industry, Japan, 

    2009.04
    -
    Present

  • American Chemical Society, 

    2005.09
    -
    Present

  • Biophysical Society, 

    2005.09
    -
    Present

  • 日本機械学会, 

    2005.04
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2016.04
    -
    2017.03

    科学研究費補助金・第2段審査・審査第一部会工学小委員会・委員, 日本学術振興会

  • 2014.04
    -
    Present

    日本機械学会広報・情報部会委員, 日本機械学会

  • 2013
    -
    2015

    科学研究費補助金　第1段審査（書面審査）委員, 日本学術振興会

  • 2012.04
    -
    Present

    日本機械学会校閲委員, 日本機械学会

  • 2011.09
    -
    Present

    Editorial Advisory Board, Journal of Applied Polymer Science

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