KEIO RESEARCHERS INFORMATION SYSTEM

Profile 【 Display / hide 】

Profile 【 Display / hide 】

• Our group will take both experimental and theoretical approaches to link the physical properties of novel soft materials with their underlying chemical structures (ranging from atomic-, through nano-, to micron-scales) as well as their industrial applications (e.g. nanomaterials, biomaterials, eco-friendly materials). Our major research targets will be polymers, and the keywords for our research projects will be "multilayered structures", "self assembly", and "composite".

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1994.04

  -

  2004.12

  Bridgestone Corporation

• 2002.09

  -

  2002.12

  Research and Postdoctoral Fellow (Univ of Cambridge, Cavendish Laboratory)

• 2003.01

  -

  2005.03

  Postdoctoral Fellow (Univ of California, Santa Barbara)

• 2005.04

  -

  2008.03

  Assistant Professor, Keio University

• 2007.04

  -

  2009.03

  機械工学科2年生クラス担任

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1990.04

  -

  1994.03

  The University of Tokyo, Faculty of Engineering, Department of Applied Physics

  University, Graduated

• 1999.10

  -

  2002.09

  University of Cambridge, Graduate School, Department of Physics (Cavendish Laboratory)

  United Kingdom, Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• PhD, University of Cambridge, Coursework, 2002.09

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Mechanics of materials and materials (Machine Material/Material Mechanics)

• Nanotechnology/Materials / Polymer materials (Polymer/Textile Materials)

• Nanotechnology/Materials / Composite materials and interfaces

• Natural Science / Biophysics, chemical physics and soft matter physics

• Life Science / Biomedical engineering

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Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Eco-materials

• Gels

• Composites

• Soft materials

• ナノ構造

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Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• ソフトマテリアル・バイオマテリアル・エコマテリアル・ナノマテリアルの微細構造、表面、物性、力学物性、粘弾性、複合化、高機能化とその実用化検討, 

  2005.04

  -

  Present

Books 【 Display / hide 】

Books 【 Display / hide 】

• 樹脂/繊維複合材料の界面制御、成形加工と評価

  犬飼駿也，黒川成貴，堀田篤, 技術情報協会, 2018.01

  Scope: 416-423 長繊維セルロースナノファイバーを複合したPVAの力学物性

• 生体吸収性材料の開発と安全性評価

  北川みどり，谷本啓示，前田知貴，堀田篤, 技術情報協会, 2017.12

  Scope: 45-52 ポリエチレングリコールをベースとしたナノコンポジットハイドロゲルの温度応答性と分解挙動

• 次世代ポリオレフィン総合研究，Vol. 11、有機シラン中間層の導入によるダイヤモンドライクカーボン/ポリオレフィン複合材料のガスバリア性向上

  前田知貴，堀田篤, 三恵社, 2017.11

  Scope: 108-112

• NANOSTRUCTURES FOR NOVEL THERAPY; Chapter 8: Electrospinning and surface modification methods for functionalized cell scaffolds

  N. Kurokawa, F. Endo, T. Maeda, A. Hotta, Elsevier, 2017.02

  Scope: Chapter 8

• 次世代ポリオレフィン総合研究，Vol. 10，ポリオレフィン材料の高ガスバリア化にむけたダイヤモンドライクカーボン（DLC）薄膜コーティングの開発

  青木拓，堀田篤, 三恵社, 2016.11

  Scope: 89-94

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Pinacol hydrate as a novel thermal energy storage medium for electric vehicles

  Kiyokawa H., Kondo Y., Koyama R., Kurokawa N., Atsushi H., Alavi S., Ota I., Ohmura R.

  Journal of Energy Storage （Journal of Energy Storage)  51 2022.07

  　View Summary

  Movement towards the gradual replacement of gasoline combustion vehicles to electrical vehicles is occurring on a global scale. Heat management of lithium-ion batteries (LIB) is necessary for long-term operation and safety of the power sources of electrical vehicles. This research suggests pinacol hydrate as a phase change material (PCM) for use as an alternative cooling media for LIB. The pinacol hydrate crystallizes under atmospheric pressure and temperatures around 45 °C, which are compatible with LIB operating conditions. Its dissociation enthalpy can control the excessive heating of the battery. The equilibrium phase transition temperature of pinacol hydrate was reported about a decade ago, but its thermal storage capacity has not been reported yet and updated quantitative measurements are required. Hence, in this study the equilibrium temperatures and dissociation enthalpies are experimentally measured for pinacol aqueous solutions prepared with mass fractions between 0.40 and 0.85. The maximum thermal storage capacity is measured by differential scanning calorimetry to be 301.9 kJ/kg for mass fraction of 0.50 which is compatible with operating conditions of up to 45.6 °C. A minimization of reservoir tank mass by 35% of that needed for conventional technologies may be possible by using pinacol hydrate.

  • Access to Document (DOI)

• Highly-toughened and dimensionally-stable TEMPO cellulose nanofiber/bio-PBSA nanocomposites fabricated via Pickering emulsion process

  Kurokawa N., Matsumoto K., Hotta A.

  Composites Science and Technology （Composites Science and Technology)  223 2022.05

  ISSN  02663538

  　View Summary

  Bioplastic poly(butylene succinate-co-adipate) (PBSA) has several advantages because of its flexibility and high biodegradability. PBSA, however, possesses poor mechanical properties and dimensional instability. To overcome this, PBSA composites with TEMPO-oxidized cellulose nanofibers (TOCN/PBSA) were fabricated via the Pickering emulsion method. Porous bio-nanocomposite TOCN/PBSA mediums were made by the Pickering emulsion method, followed by the subsequent lyophilization to obtain TOCN/PBSA films by compression molding. It was confirmed that the Pickering-emulsion condition was a key factor to control the TOCN dispersion state in composite films. The Young's modulus of TOCN/PBSA composite films increased to 305 MPa at the TOCN concentration of 5 wt%, which was almost twice as high as that of pure PBSA. The studies on the morphology and tensile testing also revealed that the dispersion state of TOCNs was important to achieve excellent reinforcement effects and to suppress the fracture of composite films caused by stress concentration. The coefficient of thermal expansion at the TOCN concentration of 5 wt% was reduced to ∼25 × 10−5 K−1, half the value of pure PBSA. It was concluded that compounding TOCNs via the Pickering emulsion method was a very effective reinforcement method to improve the mechanical properties and the dimensional stability of PBSA.

  • Access to Document (DOI)

• Morphology and mechanical property of quenched poly(L-lactide)/N,N-dimethylacetamide gels

  Inukai S., Kurokawa N., Endo F., Maeda T., Hotta A.

  Polymer （Polymer)  242 2022.03

  ISSN  00323861

  　View Summary

  Mechanically tough poly(L-lactide) (PLLA)/N,N-dimethylacetamide (DMAc) gels by rapid quenching using liquid nitrogen (LN) were synthesized. PLLA/DMAc solution at 110 °C was cooled at room temperature (PLLA-RT), or quenched by LN before keeping at RT (PLLA-LN). PLLA-RT with the PLLA concentrations of 5, 8, and 11 wt% did not form gel, while PLLA-RT with 14 and 17 wt% could form brittle gel exhibiting coarse structures. In contrast, PLLA-LN could form stable gel regardless of the PLLA concentration. The storage modulus of the gel with the PLLA concentration of 17 wt% increased from 78.7 kPa (PLLA-RT) to 563.7 kPa (PLLA-LN) at the strain of 0.1%. From the structural analysis, PLLA-RT formed spherulites (100–200 μm in diameter), whereas PLLA-LN formed relatively uniform network structures with continuous microporous skeletons without spherulites. The structural changes significantly contributed to the formation of stable, re-moldable, biodegradable, and biocompatible physical gels with ecofriendly and enhanced mechanical properties.

  • Access to Document (DOI)

• Thermoset poly(2-methoxyethyl acrylate)-based polyurethane synthesized by RAFT polymerization and polyaddition

  Tazawa S., Maeda T., Hotta A.

  Materials Chemistry and Physics （Materials Chemistry and Physics)  278 2022.02

  ISSN  02540584

  　View Summary

  A solid poly(2-methoxyethyl acrylate) (PMEA)-based polyurethane (PU) has been synthesized through reversible addition−fragmentation chain transfer (RAFT) polymerization followed by polyaddition. PMEA with four hydroxyl-groups (PMEA-(OH)4) synthesized using RAFT reagents with 4 hydroxyl groups works as an effective prepolymer and crosslinker. The thermoset PMEA-based PU can be obtained by mixing PMEA-(OH)4 and diisocyanate without additional agents for the synthesis. The temperature-independent mechanical property of the thermoset PMEA-based PU due to the chemical crosslinking points is confirmed by dynamic mechanical analysis (DMA) at temperatures ranging from 25 °C to 110 °C. The mechanical property at room temperature is also evaluated by tensile testing: The Young's modulus of PMEA-based PU increased from 454 ± 31 kPa to 574 ± 54 kPa by decreasing Mn of the PMEA prepolymer from 14,000 to 7,600. It is concluded that our synthesized PMEA-based PU exhibits sufficiently elastomeric characteristics as compared with conventional crosslinked PMEA, which may be used as a durable and more stretchable biomedical material.

  • Access to Document (DOI)

• Thermogelling Nanocomposite Hydrogel: PLGA Molecular Weight in PLGA-b-PEG-b-PLGA Affecting the Thermogelling Behavior

  Maeda T., Tanimoto K., Hotta A.

  Macromolecular Chemistry and Physics （Macromolecular Chemistry and Physics)  223 （ 1 ）  2022.01

  ISSN  10221352

  　View Summary

  Thermoresponsive gelation of the nanocomposites consisting of poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(lactic acid-co-glycolic acid) (PLGA-b-PEG-b-PLGA) triblock copolymers and LAPONITE (LAPONITE/PLGA-b-PEG-b-PLGA nanocomposites) is investigated by decreasing the molecular weights of PLGA as 1130, 900, and 470 g mol−1. As for the pure triblock copolymers, it is confirmed by UV–vis and SANS that a micellar structure with a hydrophobic core is formed even in the case of PLGA-b-PEG-b-PLGA with the lowest PLGA molecular weight of 470 g mol−1 (Triblock0.5k). As for the nanocomposites with LAPONITE, it is found that the gelation temperature (Tgel) becomes less dependent on the PLGA-b-PEG-b-PLGA concentration and more stable as the PLGA molecular weight decreases, and that Tgel of the nanocomposites almost linearly decreases as the LAPONITE concentration increases. Eventually, the nanocomposite with Triblock0.5k reaches Tgel between room temperature and physiological temperature. In addition, gradual degradation behavior is observed for the nanocomposite with Triblock0.5k. Considering the monomeric molecular weights of LA and GA at the LA/GA ratio of ≈2.0, it is concluded that the PLGA-b-PEG-b-PLGA with the lower PLGA molecular weight (i.e., Triblock0.5k) can be effectively used for thermoresponsive and degradable hydrogels targeting biomedical applications.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• A new anisotropic nanofiber/polymer composite made of different polymers for the AB-different polymer blending

  Hotta, Atsushi

  科学研究費補助金研究成果報告書 2018

• A new anisotropic nanofiber/polymer composite made of different polymers for the AB-different polymer blending (Fostering Joint International Research)

  Hotta, Atsushi

  科学研究費補助金研究成果報告書 2017

• Synthesis of polymer nanofibers and their applications

  Hotta, Atsushi

  学事振興資金研究成果実績報告書 （慶應義塾大学)  2017

• Fabrication of a new nanocomposite by the electrospinning/electrospray method

  Hotta, Atsushi

  科学研究費補助金研究成果報告書 2014

• Preparation of new functional nanofiber composites by photografting polymerizations

  Hotta, Atsushi

  科学研究費補助金研究成果報告書 2014

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 炭素材料が開く新世代医療機器の開発

  長谷部光泉，松本知博，堀田篤，鈴木哲也

  New Diamond (ニューダイヤモンドフォーラム)  31 ( 117 ) 5 - 10 2015.04

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Synthesis of PMMA-PMEA-PMMA triblock copolymer and its mechanical and anti-thrombogenic properties

  N. Kurokawa, F. Endo, K. Bito, T. Maeda, A. Hotta

  日本化学会第98春季年会2018 (日本大学理工学部　船橋キャンパス，千葉) , 

  2018.03

  , 

  Oral presentation (general), 日本化学会

• Solidification of poly(2-methoxyethyl aclylate) via block copolymerization with poly(methyl methacrylate) and its properties

  N. Kurokawa, F. Endo, K. Bito, T. Maeda, A. Hotta

  日本化学会第98春季年会2018 (日本大学理工学部　船橋キャンパス，千葉) , 

  2018.03

  , 

  Poster presentation, 日本化学会

• 固体ポリメトキシエチルアクリレートの作製とその力学物性評価

  松枝知征，堀田篤

  日本機械学会関東支部関東学生会第57回学生員卒業研究発表講演会 (電気通信大学，調布) , 

  2018.03

  , 

  Oral presentation (general), 日本機械学会

• X線視認性を有する医療用マイクロビーズの作製と空気プラズマ処理を利用したその表面改質

  岡本穣，堀田篤

  日本機械学会関東支部関東学生会第57回学生員卒業研究発表講演会 (電気通信大学，調布) , 

  2018.03

  , 

  Oral presentation (general), 日本機械学会

• カチオン性のポリスチレンナノ粒子の作製

  篠田航希，堀田篤

  日本機械学会関東支部関東学生会第57回学生員卒業研究発表講演会 (電気通信大学，調布) , 

  2018.03

  , 

  Oral presentation (general), 日本機械学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 熱可逆性を有する含水率99%以上の高強度ダブルネットワークハイドロゲルの創製

  2019.06

  -

  2022.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

• 高耐熱・高強度スーパーエンプラナノファイバーを作る

  2019.04

  -

  2024.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A) , Principal investigator

• ポリマーゲルを用いた人工血栓作製および血管内皮細胞を用いた血管内損傷試験モデル構築

  2018.04

  -

  Present

  Joint research, Principal investigator

• ポリマーの熱可塑性・形状記憶性・自己修復性の基礎研究

  2018.04

  -

  2019.03

  Commissioned ｒesearch, No Setting

• ナノファイバ複合材料

  2018.04

  -

  2019.03

  Commissioned ｒesearch, Principal investigator

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Works 【 Display / hide 】

Works 【 Display / hide 】

• 血管再狭窄 長期防止に道 薬剤溶出ステント 被覆技術開発 血液付着せず内皮化増進

  長谷部光泉、鈴木哲也、堀田篤

  日刊工業新聞 朝刊21面, 

  2016.12

  -

  Present

  , 

  Other

  　View Details

  東海大学医学部の長谷部光泉教授と慶応義塾先端科学技術研究センターの鈴木哲也所長、慶応義塾大学理工学部の堀田篤教授らは、内皮細胞の増殖を促す薬剤溶出ステント用のコーティング技術を開発した。ステントへの血液成分の付着しにくさと、内皮細胞への覆われやすさを両立させた。患者の血管の再狭窄（きょうさく）を長期的に防げる可能性がある。新技術では、まずリン脂質ポリマー（ＭＰＣ）で表面を覆い、その上にダイヤモンド・ライク・カーボン（ＤＬＣ）を成膜する。

Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• 固体（ポリ（2-メトキシエチルアクリレート）

  Date applied： 特願2018-35438  2018.02 

  Patent, Single

• 被覆プラスチック成形体及びその製造方法

  Date applied： 特願2017-249628  2018.01 

  Patent, Single

• 樹脂容器及び樹脂フィルム

  Date applied： 特願2014-021475  2014.02 

  Patent, Single

• 成形体

  Date applied： 特願2013-234700  2013.11 

  Patent, Single

• 蒸着用プラスチック成形体、ガスバリア性プラスチック成形体及びそれらの製造方法

  Date applied： 特許願　2012-270636  2012.12 

  Patent, Single

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 関東学生会第57回学生員卒業研究発表講演会ベストプレゼンテーション賞

  松枝知征，堀田篤, 2018.03, 機械学会, 固体ポリメトキシエチルアクリレートの作製とその力学物性評価

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 関東学生会第57回学生員卒業研究発表講演会ベストプレゼンテーション賞

  岡本穣，堀田篤, 2018.03, 機械学会, X線視認性を有する医療用マイクロビーズの作製と空気プラズマ処理を利用したその表面改質

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 関東学生会第57回学生員卒業研究発表講演会ベストプレゼンテーション賞

  牧良洋，堀田篤, 2018.03, 機械学会, 有機シランおよびDLCをコーティングしたポリプロピレンの酸素バリア性

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 関東学生会第56回学生員卒業研究発表講演会ベストプレゼンテーション賞

  市村弘毅，堀田篤, 2017.03, 機械学会, 光グラフト重合により表面改質をしたナノファイバとポリスチレンの複合材料とその力学物性

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 第30回ダイヤモンドシンポジウム最優秀賞

  中山正光, 長谷部光泉, 前川駿人, 尾藤健太, 大和裕哉, 中野裕揮, 田中美夏, 白幡智史, 林敏彦, 嶺貴彦, 松本知博, 堀田篤, 鈴木哲也, 2016.11, 高分子学会, フッ素添加DLCの抗血栓性メカニズムの解明: 血漿タンパク質吸着量および吸着形態の評価

  Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• PHYSICS A

  2022

• MATERIAL DESIGN

  2022

• LABORATORIES IN SCIENCE AND TECHNOLOGY

  2022

• INTRODUCTION TO MATERIALS SCIENCE

  2022

• INDEPENDENT STUDY ON SCIENCE FOR OPEN AND ENVIRONMENTAL SYSTEMS

  2022

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 物理学Ａ

  Keio University

  2018.04

  -

  2019.03

  , 

  Spring Semester, Lecture, Within own ｆaculty, 200people

• 開放環境科学特別研究第2

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

• 開放環境科学特別研究第１

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

• 開放環境科学課題研究

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

• 卒業研究

  Keio University

  2018.04

  -

  2019.03

  , 

  Full academic year, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本ポリオレフィン総合研究会, 

  2013.04

  -

  Present

• Society of Polyolefin Science & Industry, Japan, 

  2009.04

  -

  Present

• American Chemical Society, 

  2005.09

  -

  Present

• Biophysical Society, 

  2005.09

  -

  Present

• 日本機械学会, 

  2005.04

  -

  Present

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2016.04

  -

  2017.03

  科学研究費補助金・第2段審査・審査第一部会工学小委員会・委員, 日本学術振興会

• 2014.04

  -

  Present

  日本機械学会広報・情報部会委員, 日本機械学会

• 2013

  -

  2015

  科学研究費補助金　第1段審査（書面審査）委員, 日本学術振興会

• 2012.04

  -

  Present

  日本機械学会校閲委員, 日本機械学会

• 2011.09

  -

  Present

  Editorial Advisory Board, Journal of Applied Polymer Science

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