論文 - 鈴木　哲也

Improved abrasion resistance of silica-based CVD thin films on polycarbonate substrates for automotive applications

S.Tanaka, H.Endo, A.Shirakura and T.Suzuki

J. Vac. Sci. Technol  （ B39 ） 040602 - 040606 2021年

研究論文（学術雑誌）, 共著, 査読有り

The property of adhesion and biocompatibility of silicon and fluorine dopeddiamond-like carbon films

M. Toyonaga, T. Hasebe,S. Maegawa and T. Suzuki

Diamond and Related Materials 119   1 - 9 2021年

研究論文（学術雑誌）, 共著, 査読有り

Analytical TEM Observation of the Flame-Ablated Surfaceof Borosilicate-Glass Vials

K. Mikamoto,M. Takeuchi, A. Shirakura and T. Suzuki

Glass Physics and Chemistry 47   91 - 96 2021年

共著, 査読有り

Improvement of Durability and Sliding Properties of　Food Packaging Equipment by Combined Treatmentof Diamond-Like Carbon Coatingand Fine Particle Bombarding

K.Mikamoto,Y.Tsubaki, A.Shirakura and T.Suzuki

Journal of Applied Packaging Research 12   54 - 62 2020年

研究論文（学術雑誌）, 共著

Lymphangiography and Post-lymphangiographic Multidetector CT for Preclinical Lymphatic Interventions in a Rabbit Model

Matsumoto T., Tomita K., Maegawa S., Nakamura T., Suzuki T., Hasebe T.

CardioVascular and Interventional Radiology （CardioVascular and Interventional Radiology）  42 （ 3 ） 448 - 454 2019年03月

ISSN  01741551

　概要を見る

Purpose: To describe the feasibility of lymphangiography and the visibility of the lymphatic system using post-lymphangiographic multidetector CT (MDCT) for preclinical lymphatic interventions in a rabbit model. Materials and Methods: Lymphangiography via the popliteal lymph node or vessel after surgical exposure was performed, using six healthy female Japanese White rabbits. Lipiodol was manually injected for lymphangiography. Post-lymphangiographic MDCT examinations were performed in all rabbits. The dataset images were subjected to image processing analysis utilizing the three-dimensional maximum intensity projection technique. Three reviewers evaluated the degree of depiction of the lymphatic system using a four-point visual score (1, poor; 2, fair; 3, good; 4, excellent). The distance between the body surface and cisterna chyli was measured on post-lymphangiographic MDCT axial image. Results: Lymphangiography was successfully performed in all rabbits. The popliteal lymph node was detectable in 90%. The visualization of lymphatic system via the popliteal node was achieved in 89%. Mean visual scores of > 3.0 were realized by the right femoral lymphatic vessel, left femoral lymphatic vessel, left iliac lymphatic vessel, left lumbar lymphatic trunks and cisterna chyli, whereas mean visual scores of < 3.0 were yielded by the right iliac lymphatic vessel, right lumbar lymphatic trunks and thoracic duct. The distance between the body surface and cisterna chyli on post-lymphangiographic MDCT axial images was 4.33 ± 0.14 cm. Conclusion: Lymphangiography is feasible, and the visibility of the lymphatic system on post-lymphangiographic MDCT in a rabbit model provides enough information for interventional radiologists to perform preclinical lymphatic interventions.

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Micropatterning of a 2-methacryloyloxyethyl phosphorylcholine polymer surface by hydrogenated amorphous carbon thin films for endothelialization and antithrombogenicity

Bito K., Hasebe T., Maegawa S., Kitagawa T., Matsumoto T., Suzuki T., Hotta A.

Acta Biomaterialia （Acta Biomaterialia）  87   187 - 196 2019年03月

ISSN  17427061

　概要を見る

The existing first-generation drug-eluting stent (DES) has caused late and very late stent thrombosis related to incomplete stent endothelialization. Hence, biomaterials that possess sufficient anti-thrombogenicity and endothelialization with the controlled drug release system have been highly required. In this work, we have developed a newly designed drug-release platform composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, a non-thrombogenic polymer, and micropatterned hydrogenated amorphous carbon (a-C:H), a cell-compatible thin film. The platelet adhesion and the endothelial cell adhesion behavior on the micropatterned substrates were investigated in vitro. The results indicated that the micropatterned a-C:H/MPC polymer substrates effectively supported the human umbilical vein endothelial cell (HUVEC) proliferation, while suppressing the platelet adhesion. Interestingly, the HUVEC exhibited different shape and behavior by changing the island size of the micropatterned a-C:H. By introducing both a non-thrombogenic polymer and cell-compatible thin films through a simple patterning method, we demonstrated that the platform had the potential to be utilized as a base material for DES with cell controllability. Statement of significance: The current first-generation drug-eluting stents (DES) would cause late and very late stent thrombosis due to the incomplete endothelialization of the metal stent material. In this work, we have developed a new DES platform composed of a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer micropatterned by hydrogenated amorphous carbon (a-C:H). Two types of differently micropatterned a-C:H stent surface were made. Our studies revealed that the micropatterned a-C:H/MPC polymer substrates could effectively enhance the endothelial cell (EC) proliferation, simultaneously suppressing the platelet adhesion, becoming a highly biocompatible material especially for indwelling devices including a drug-release device. The new drug-release platform could be utilized as a base material for cell-controllable coating on DES.

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Reuse of PET bottle by coating DLC films

Tetsuya Suzuki

J Environ Anal Chem 2018 5   13 2018年09月

研究論文（学術雑誌）, 単著

Synthesis of diamond-like hydrocarbon films by atmospheric pressure filamentary dielectric barrier discharge

Suzuki T., Shirakura A.

IOP Conference Series: Materials Science and Engineering （IOP Conference Series: Materials Science and Engineering）  369 （ 1 ）  2018年06月

ISSN  17578981

　概要を見る

Diamond-like hydrocarbon (DLHC, a-C:H) films were synthesized under atmospheric pressure filamentary by dielectric discharge (FDBD) to improve their mechanical properties compared to the films synthesized by glow dielectric barrier discharge (GDBD). GDBD is generally used for atmospheric pressure-plasma-enhanced chemical vapour deposition. The discharge form transitioned from GDBD to FDBD by increasing the gap between electrodes from 1 to 4 mm. The hardness of the films increased from 3.7 to 11.9 GPa by using FDBD. The results indicate that hard DLHC films can be synthesized at room temperature and on a large area under atmospheric pressure using FDBD.

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In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment

Ota T., Nakayama M., Kanno Y., Suzuki T., Miki N.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) （Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)）  2018-January   412 - 414 2018年04月

ISSN  9781538647820

　概要を見る

In this report, we experimentally investigated the blood hemofiltration capacity of a nanoporous dialysis membrane (poly(ether sulfone), PES) whose surface was modified with fluorine-doped diamond-like carbon(f-DLC). Surface modification of the nanoporous membrane without clogging the nanopores is challenging. In vitro experiments revealed that the modified membrane successfully exhibited water permeability of one-tenth of the untreated. In vivo experiments with ultra-small hemofiltration devices composed of f-DLC PES membranes using SD rats were also conducted for the first time. The results proved that the f-DLC coated PES membrane can be used for hemofiltration, which will extend the lifetime of microfluidics-based implantable artificial kidney.

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Hard Carbon Films Synthesized By Atmospheric Pressure Filamentary Dielectric Barrier Discharge

Suzuki T., Shirakura A.

Macromolecular Symposia （Macromolecular Symposia）  3 （ 1 ） 1 - 4 2018年

研究論文（国際会議プロシーディングス）, 単著,  ISSN  10221360

　概要を見る

To synthesize hydrogenated amorphous carbon (a-C:H) films, filamentary dielectric discharge (FDBD) is used to improve their mechanical properties compared to the films synthesized by glow dielectric barrier discharge (GDBD), which is generally used for atmospheric pressure-plasma-enhanced chemical vapor deposition. The discharge form transitioned from GDBD to FDBD when the gap between the electrodes is increased from 1 to 4 mm. The hardness of the films increased from 3.7 to 11.9 GPa by using FDBD. The results indicate that hard a-C:H films can be synthesized at room temperature by atmospheric pressure using FDBD.

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Fluorine-Incorporated Amorphous Carbon Coating Inhibits Adhesion of Blood Cells to Biomaterials

A.Horikawa,S.Maegawa,T.Hasebe,T.Matsumoto,M.Tanaka,K.Takahashi, T.Suzuki

Sensors and Materials 29 （ 6 ） 795 - 803 2017年05月

研究論文（学術雑誌）, 共著, 査読有り

Microballoon-related interventions in various endovascular treatments of body trunk lesions

(1) Tomohiro Matsumoto, Kosuke Tomita, Satoshi Suda, Kazunobu Hashida, Shunto Maegawa, Toshihiko Hayashi, Takuji Yamagami, Suzuki Tetsuya, Terumitsu Hasebe

Min. Invas. Ther. Allied. Technol 27   2 - 10 2017年

研究論文（学術雑誌）, 共著, 査読有り

Biocompatibility Tests and Adhesion Improvements for Hydrogen-free Amorphous Carbon for Blood-Contacting Medical Devices

Y.Yamato, S.Maegawa, T.Hasebe, K.Bito, T.Matsumoto, T.Mine, T.Hayashi, A.Hotta, T. Suzuki

Sensors and Materials 29   843 - 854 2017年

研究論文（学術雑誌）, 共著, 査読有り

Weatherability of Amorphous Carbon Films Synthesized by Atmospheric Pressure Plasma Chemical Vapor Deposition

Reiko Inaba, Eiichi Kishimoto , Akira Shirakura ,and Tetsuya Suzuki

Sensors and Materials 29   835 - 841 2017年

研究論文（学術雑誌）, 共著, 査読有り

Effect of Ar and He Dilution Gas Mixture Ratio on Hardness of a-C:H Films Synthesized by Atmospheric Pressure PECVD

E.Kishimoto, S.Maegawa, A.Shirakura, T.Suzuki

J. Vac. Sci. Technol 35   041502 2017年

研究論文（学術雑誌）, 共著, 査読有り

In vitro basic fibroblast growth factor (bFGF) delivery using an antithrombogenic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer coated with a micro-patterned diamond-like carbon (DLC) film.

Hasebe T, Bito K, Maegawa S, Maeda T, Matsumoto T, Suzuki T, Hotta A

Journal of Biomedical Materials Research A  （ 105A ） 2284 - 3391 2017年

研究論文（学術雑誌）, 共著, 査読有り

Time course analysis of antithrombogenic properties of fluorinated diamond-like carbon coating by accelerated aging tests: Quality control for medical device commercialization

S. Maegawa, T. Hasebe, Y. Yamato, K. Bito, S. Nagashima, T. Hayashi, T. Mine, T. Matsumoto, A. Hotta, T, Suzuki

Diam. Relat. Mater 70   33 - 38 2016年09月

研究論文（学術雑誌）, 共著, 査読有り

Effects of dilution gas on characteristics of SiOC(-H) films synthesized by atmospheric pressure plasma CVD

T. Mori, T. Masuko, A. Shirakura, T. Suzuki

Surf. Coat. Technol 307   1065 - 1069 2016年07月

研究論文（学術雑誌）, 共著, 査読有り

Gas Barrier Property of Silica-based Films on PET synthesized by Atmospheric Pressure Plasma Enhanced CVD

M. Moritoki, T. Masuko, T. Mori, T. Suzuki

Surf. Coat. Technol 307   1070 - 1073 2016年06月

研究論文（学術雑誌）, 共著, 査読有り

Growth process of a-C:H films synthesized by atmospheric pressure plasma enhanced CVD method using N2 and He as a dilution gas

T. Mori, T. Sakurai, T. Sato, A. Shirakura, T. Suzuki

Jpn. J. Appl. Phys 55   045503 2016年

研究論文（学術雑誌）, 共著, 査読有り