慶應義塾研究者情報データベース

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• スポーツ医学研究センター, 兼担所員

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• 健康マネジメント学, 慶應義塾大学, 課程, 2007年03月

• 博士（健康マネジメント学）, 慶應義塾大学, 課程, 2011年08月

  Effects of resistance training with whole-body vibration on muscle fitness and program design for untrained healthy adults

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• ライフサイエンス / 医療管理学、医療系社会学 （老化　運動）

• ライフサイエンス / スポーツ科学

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• 国際比較

• 老化　疫学　プロテオミクス解析　サルコペニア

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• Six-year transition patterns of activities of daily living in octogenarians: Tokyo oldest old in total health study

  Osawa, Y., Abe, Y., Takayama, M. and Arai, Y.

  BMC Geriatr 25 （ 1 ） 638 2025年08月

  単著,  ISSN  1471-2318

  　概要を見る

  BACKGROUND: With global super-aging, understanding the longitudinal changes in activities of daily living (ADLs) among older adults is critical for maintaining their functional independence, particularly in later life. However, evidence of longitudinal ADL patterns in Asian octogenarians remains limited. This study examined 6-year ADL transition patterns among community-dwelling older adults in Japan aged 85 years or above using latent transition analysis (LTA) to identify dynamic changes and associated factors. METHODS: The present study used data from the Tokyo Oldest Old Survey on Total Health study, a prospective cohort of 538 participants aged 85 years or older. ADL was assessed using the Barthel index at baseline, 3 years, and 6 years. Through LTA, latent clusters at each time point were identified, and transition probabilities across clusters were estimated. Cluster characteristics and transitions were examined relative to demographic, physical, cognitive, lifestyle, and biological factors. Random forest analysis was used to identify predictors of longitudinal ADL decline. RESULTS: Three ADL clusters were identified: "Robust," "Partially Impaired," and "Impaired." Over six years, transitions to worse functional states or mortality were common, particularly among those in the "Partially Impaired" and "Impaired" clusters. Participants in the "Robust" cluster who maintained functional independence demonstrated better physical and cognitive functions, healthier lifestyles, and optimal nutritional and inflammatory profiles. Random forest analysis revealed "Stairs" and "Dressing" as critical predictors of overall ADL deterioration. CONCLUSIONS: The results contribute to the understanding of aging-related functional trajectories and offer actionable insights for healthcare planning and intervention development. TRIAL REGISTRATION: This study was approved by the ethics committees of the Keio University School of Medicine (no. 20070047), and written informed consent was obtained from all participants. The TOOTH study was registered in the University Hospital Medical Information Network Clinical Trial Registry under ID UMIN000001842. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-025-06308-7.

  • Access to Document (DOI)

• Preventive Effects of Physical Activity on the Development of Atherosclerosis: A Narrative Review

  Osawa, Y. and Arai, Y.

  J Atheroscler Thromb 32 （ 1 ） 11 - 19 2025年01月

  単著,  ISSN  1880-3873

  　概要を見る

  Atherosclerosis, a major contributor to cardiovascular diseases (CVD), remains a leading cause of global mortality and morbidity. The pathogenesis of atherosclerosis involves a complex interplay of endothelial dysfunction, chronic inflammation, lipid accumulation, and arterial stiffness. Among the various preventive strategies, physical activity has emerged as a highly effective, non-pharmacological intervention. This review examines the preventive effects of different types of exercise-specifically aerobic exercise, resistance training, and combined training-on atherosclerosis development. Drawing on evidence from landmark studies, we explore the underlying mechanisms by which these exercise modalities improve endothelial function, reduce systemic inflammation, and enhance lipid profiles, thereby mitigating the progression of atherosclerosis. Additionally, the review discusses the dose-response relationship between physical activity and cardiovascular health, the differential effects of exercise intensities, and the potential risks associated with high-intensity training. The synergistic benefits of combined aerobic and resistance training are highlighted, particularly in populations with metabolic syndrome or other high-risk conditions. Emerging trends in personalized exercise medicine and the use of wearable technology for monitoring physical activity are also addressed, underscoring the potential for tailored exercise prescriptions to maximize cardiovascular health. By integrating current research findings, this review provides insights into effective exercise strategies for reducing cardiometabolic risk and emphasizes the importance of personalized approaches in exercise interventions.

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• Longitudinal association between muscle and bone loss: Results of US and Japanese cohort studies.

  Osawa Y, An Y, Nishita Y, Matsui Y, Takemura M, Simonsick EM, Shimokata H, Otsuka R, Arai H, Ferrucci L

  Journal of cachexia, sarcopenia and muscle （Journal of Cachexia, Sarcopenia and Muscle）  15 （ 2 ） 746 - 755 2024年04月

  単著,  ISSN  2190-5991

  　概要を見る

  Background: Muscle and bone are physiologically interconnected, but joint changes of muscle and bone with aging, and whether the muscle-bone changes are different by sex and by country has been little studied. We examined longitudinal associations of bone mineral density (BMD) and muscle mass or muscle strength in community-dwelling 65 years or older in the United States and Japan. Methods: The present analytic sample included 1129 women and men from the Baltimore Longitudinal Study of Aging (BLSA) (mean age, 74.5 ± 7.5 years; women, 49.8%) and 1998 women and men from the National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) (mean age, 70.0 ± 4.5 years; women, 51.4%). Median follow-up was 4.6 (min-max, 0–15.4) years in the BLSA and 4.0 (min-max, 0–13.4) years in the NILS-LSA. We selected visits at which participants had BMD (whole body, pelvic, femoral neck, trochanter, and Ward's triangle BMDs) and muscle mass [appendicular lean mass, (ALM)] measured by DXA scan. In each bone site, we ran cohort-specific bivariate linear mixed-effects models adjusted for baseline age, sex, body height, body weight, fat mass, education year, and smoking status. Race was an additional adjustment in the BLSA. Additionally, we performed sex-specific analyses. Results: In the BLSA, the rate of change in ALM positively correlated with the rate of change in the whole body (rho = 0.30, P < 0.0001) and pelvic BMD (rho = 0.24, P < 0.0001), but not in trochanter, femoral neck, or Ward's triangle BMD (P > 0.05). In the NILS-LSA, ALM positively correlated with the rate of change in all bone sites (rho ranged from 0.20 to 0.71, P < 0.01). In women, ALM positively correlated with the rate of change in all bone sites in both cohorts (in the NILS-LSA, rho ranged from 0.35 to 0.91, P < 0.01; in the BLSA, rho ranged from 0.26 to 0.56, P < 0.05) except for femoral neck BMD in the BLSA. In men, ALM positively correlated with pelvic, trochanter, and Ward's triangle BMD in the NILS-LSA (rho ranged from 0.45 to 0.68, P < 0.0001), and whole body and trochanter BMD in the BLSA (both, rho = 0.20, P < 0.05). Conclusions: Muscle loss co-occurred with bone loss in both cohorts, but the association in the NILS-LSA tended to be stronger than in the BLSA, and the association was higher in women than in men, implying that the association may differ by sex and country.

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• Plasma amino acid signature for sarcopenic phenotypes in community-dwelling octogenarians: Results from the Kawasaki Aging Wellbeing Project.

  Osawa Y, Candia J, Abe Y, Tajima T, Oguma Y, Arai Y

  Experimental gerontology （Experimental Gerontology）  178   112230 2023年07月

  単著,  ISSN  0531-5565

  　概要を見る

  Sarcopenia is one of the primary risk factors for various adverse health events in later life. However, its pathophysiology in the very old population remains unclear. Hence, this study aimed to examine whether plasma free amino acids (PFAAs) correlate with major sarcopenic phenotypes (i.e., muscle mass, muscle strength, and physical performance) in community-dwelling adults aged 85–89 years living in Japan. Cross-sectional data from the Kawasaki Aging Well-being Project were used. We included 133 adults aged 85–89 years. In this study, fasting blood was collected to measure 20 plasma PFAAs. Measures for the three major sarcopenic phenotypes included appendicular lean mass assessed by multifrequency bioimpedance, isometric handgrip strength, and gait speed from a 5 m walk at a usual pace. Furthermore, we used phenotype–specific elastic net regression models adjusted for age centered at 85 years, sex, body mass index, education level, smoking status, and drinking habit to identify significant PFAAs for each sarcopenic phenotype. Higher histidine and lower alanine levels were associated with poor gait speed, but no PFAAs correlated with muscle strength or mass. In conclusion, PFAAs such as plasma histidine and alanine are novel blood biomarkers associated with physical performance in community-dwelling adults aged 85 years or older.

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• The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults.

  Shibuki T, Iida M, Harada S, Kato S, Kuwabara K, Hirata A, Sata M, Matsumoto M, Osawa Y, Okamura T, Sugiyama D, Takebayashi T

  Archives of gerontology and geriatrics （Archives of Gerontology and Geriatrics）  109   104948 2023年06月

  単著,  ISSN  0167-4943

  　概要を見る

  Purpose: This study aimed to examine the association between sleep duration and quality and sarcopenia, assessed by factors such as low muscle mass (LMM), low muscle strength (LMS), and low physical performance (LPP) among older community-dwellers in Japan. Methods: In this cross-sectional study, a total of 2,069 (men, 902; women, 1,167) participants aged 65 to 80 years were included. Sarcopenia and each low physical function were defined using the definitions of the Asian Working Groups of Sarcopenia 2019. Sleep duration was stratified into three categories: short sleep (<6 h), normal sleep (6-8 h), and long sleep (>8 h). Sleep quality was classified into two groups based on 8-item Athens Insomnia Scale score: insomnia (≥6), and non-insomnia (<6). We analyzed the association between sleep parameters and sarcopenia, including low physical functions, by logistic regression analysis. Results: Compared to normal sleepers, long sleepers had a positive association with sarcopenia (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.25-3.58). In particular, long sleep was strongly associated with LMS (OR 1.77, 95%CI 1.07-2.94) and LPP (OR 1.90, 95%CI 1.25-2.88). On the other hand, poor sleep quality was not associated with sarcopenia in long sleepers, but in normal sleepers. Conclusions: Long sleep was associated with sarcopenia, including LMS and LPP. However, in long sleepers, insomnia was not associated with sarcopenia or any of its components.

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

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• 超高齢者フレイル対策の提言に資する国際比較共同研究

  大澤, 祐介

  科学研究費補助金研究成果報告書 2017年

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• 筋肉を起点とする身体の老化現象とその背景因子：国際共同研究

  2024年04月

  -

  2028年03月

  科学研究費助成事業 基盤研究(B), その他,  研究代表者

• 筋肉を起点とする身体の老化現象とその背景因子：国際共同研究

  2024年04月

  -

  2028年03月

  大澤 祐介, 基盤研究(B), 補助金,  研究代表者

• 身体活動推進のための地域介入 多世代複合コホート研究の活用と政策展開

  2023年04月

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  継続中

  日本学術振興会 , 科学研究費助成事業 基盤研究(B), 補助金,  研究分担者

• 老化による運動器の形質変化：オステオサルコペニアに関するプロテオーム解析

  2021年04月

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  2024年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 大澤 祐介, 基盤研究(C), 補助金,  研究代表者

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• Outstanding Poster Presentation Award

  2023年06月, 12th IAGG Asia/Oceania Regional Congress 2023, Longitudinal Association Between Muscle Mass and Bone Mineral Density: Findings from Baltimore Longitudinal Study of Aging and National Institute for Longevity Sciences-Longitudinal Study of Aging

  受賞区分： 国際学会・会議・シンポジウム等の賞

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• 公衆衛生実践

  2025年度

• 健康マネジメント概論

  2025年度

• 運動疫学

  2025年度

• 健康マネジメント合同演習

  2025年度

• 臨床入門

  2025年度

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