Osawa, Yusuke



Graduate School of Health Management (Shonan Fujisawa)


Associate Professor

Other Affiliation 【 Display / hide

  • Sports Medicine Research Center, 兼担所員

Academic Degrees 【 Display / hide

  • Master of Science in Health Management, Keio University, Coursework, 2007.03

  • 博士(健康マネジメント学), Keio University, Coursework, 2011.08

    Effects of resistance training with whole-body vibration on muscle fitness and program design for untrained healthy adults


Research Areas 【 Display / hide

  • Life Science / Medical management and medical sociology (Aging Exercise)

  • Life Science / Sports sciences

Research Keywords 【 Display / hide

  • 国際比較

  • Aging; Epidemiology; Proteomics; Sarcopenia


Papers 【 Display / hide

  • Longitudinal association between muscle and bone loss: Results of US and Japanese cohort studies

    Y Osawa, Y An, Y Nishita, Y Matsui, M Takemura, EM Simonsick, ...

    Journal of Cachexia, Sarcopenia and Muscle (Journal of Cachexia, Sarcopenia and Muscle)  15 ( 2 ) 746 - 755 2024.04

    Single Work,  ISSN  2190-5991

     View Summary

    Background: Muscle and bone are physiologically interconnected, but joint changes of muscle and bone with aging, and whether the muscle-bone changes are different by sex and by country has been little studied. We examined longitudinal associations of bone mineral density (BMD) and muscle mass or muscle strength in community-dwelling 65 years or older in the United States and Japan. Methods: The present analytic sample included 1129 women and men from the Baltimore Longitudinal Study of Aging (BLSA) (mean age, 74.5 ± 7.5 years; women, 49.8%) and 1998 women and men from the National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) (mean age, 70.0 ± 4.5 years; women, 51.4%). Median follow-up was 4.6 (min-max, 0–15.4) years in the BLSA and 4.0 (min-max, 0–13.4) years in the NILS-LSA. We selected visits at which participants had BMD (whole body, pelvic, femoral neck, trochanter, and Ward's triangle BMDs) and muscle mass [appendicular lean mass, (ALM)] measured by DXA scan. In each bone site, we ran cohort-specific bivariate linear mixed-effects models adjusted for baseline age, sex, body height, body weight, fat mass, education year, and smoking status. Race was an additional adjustment in the BLSA. Additionally, we performed sex-specific analyses. Results: In the BLSA, the rate of change in ALM positively correlated with the rate of change in the whole body (rho = 0.30, P < 0.0001) and pelvic BMD (rho = 0.24, P < 0.0001), but not in trochanter, femoral neck, or Ward's triangle BMD (P > 0.05). In the NILS-LSA, ALM positively correlated with the rate of change in all bone sites (rho ranged from 0.20 to 0.71, P < 0.01). In women, ALM positively correlated with the rate of change in all bone sites in both cohorts (in the NILS-LSA, rho ranged from 0.35 to 0.91, P < 0.01; in the BLSA, rho ranged from 0.26 to 0.56, P < 0.05) except for femoral neck BMD in the BLSA. In men, ALM positively correlated with pelvic, trochanter, and Ward's triangle BMD in the NILS-LSA (rho ranged from 0.45 to 0.68, P < 0.0001), and whole body and trochanter BMD in the BLSA (both, rho = 0.20, P < 0.05). Conclusions: Muscle loss co-occurred with bone loss in both cohorts, but the association in the NILS-LSA tended to be stronger than in the BLSA, and the association was higher in women than in men, implying that the association may differ by sex and country.

  • Plasma amino acid signature for sarcopenic phenotypes in community-dwelling octogenarians: Results from the Kawasaki Aging Wellbeing Project

    Y Osawa, J Candia, Y Abe, T Tajima, Y Oguma, Y Arai

    Experimental Gerontology 178, 112230 (Experimental Gerontology)  178   112230 2023.07

    Single Work,  ISSN  0531-5565

     View Summary

    Sarcopenia is one of the primary risk factors for various adverse health events in later life. However, its pathophysiology in the very old population remains unclear. Hence, this study aimed to examine whether plasma free amino acids (PFAAs) correlate with major sarcopenic phenotypes (i.e., muscle mass, muscle strength, and physical performance) in community-dwelling adults aged 85–89 years living in Japan. Cross-sectional data from the Kawasaki Aging Well-being Project were used. We included 133 adults aged 85–89 years. In this study, fasting blood was collected to measure 20 plasma PFAAs. Measures for the three major sarcopenic phenotypes included appendicular lean mass assessed by multifrequency bioimpedance, isometric handgrip strength, and gait speed from a 5 m walk at a usual pace. Furthermore, we used phenotype–specific elastic net regression models adjusted for age centered at 85 years, sex, body mass index, education level, smoking status, and drinking habit to identify significant PFAAs for each sarcopenic phenotype. Higher histidine and lower alanine levels were associated with poor gait speed, but no PFAAs correlated with muscle strength or mass. In conclusion, PFAAs such as plasma histidine and alanine are novel blood biomarkers associated with physical performance in community-dwelling adults aged 85 years or older.

  • The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults

    T Shibuki, M Iida, S Harada, S Kato, K Kuwabara, A Hirata, M Sata, ...

    Archives of Gerontology and Geriatrics 109, 104948 (Archives of Gerontology and Geriatrics)  109   104948 2023.06

    Single Work,  ISSN  0167-4943

     View Summary

    Purpose: This study aimed to examine the association between sleep duration and quality and sarcopenia, assessed by factors such as low muscle mass (LMM), low muscle strength (LMS), and low physical performance (LPP) among older community-dwellers in Japan. Methods: In this cross-sectional study, a total of 2,069 (men, 902; women, 1,167) participants aged 65 to 80 years were included. Sarcopenia and each low physical function were defined using the definitions of the Asian Working Groups of Sarcopenia 2019. Sleep duration was stratified into three categories: short sleep (<6 h), normal sleep (6-8 h), and long sleep (>8 h). Sleep quality was classified into two groups based on 8-item Athens Insomnia Scale score: insomnia (≥6), and non-insomnia (<6). We analyzed the association between sleep parameters and sarcopenia, including low physical functions, by logistic regression analysis. Results: Compared to normal sleepers, long sleepers had a positive association with sarcopenia (odds ratio [OR] 2.11, 95% confidence interval [CI] 1.25-3.58). In particular, long sleep was strongly associated with LMS (OR 1.77, 95%CI 1.07-2.94) and LPP (OR 1.90, 95%CI 1.25-2.88). On the other hand, poor sleep quality was not associated with sarcopenia in long sleepers, but in normal sleepers. Conclusions: Long sleep was associated with sarcopenia, including LMS and LPP. However, in long sleepers, insomnia was not associated with sarcopenia or any of its components.

  • Plasma growth and differentiation factor 15 predict longitudinal changes in bone parameters in women, but not in men

    Y Osawa, T Tanaka, RD Semba, G Fantoni, R Moaddel, J Candia, ...

    The Journals of Gerontology: Series A (Journals of Gerontology - Series A Biological Sciences and Medical Sciences)  77 ( 10 ) 1951 - 1958 2022.04

    Single Work,  ISSN  1079-5006

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    Bone fragility can progress with aging, but biomarkers to detect emerging osteopenia have not been fully elucidated. Growth/ differentiation factor 15 (GDF-15) has pleiotropic roles in a broad range of age-related conditions, but its association with osteopenia is unknown. We examined the relationship between plasma GDF-15 levels and rate of change in bone parameters over 9 years of follow-up in 596 adults in the InCHIANTI study (baseline age, 65–94 years; women, 52.4%; mean follow-up, 7.0 ± 3.0 years). Plasma GDF-15 concentrations were measured using the 1.3k HTS SOMAscan assay. Eight bone parameters were measured in the right tibia by peripheral quantitative computed tomography; total bone density, trabecular bone density, medullary plus trabecular bone density, cortical bone density, total bone area, cortical bone area, medullary bone area, and minimum moment of inertia (mMOI). We ran sex-specific linear mixed-effect models with random intercepts and slopes adjusted for age, age-squared, education, body mass index, the rate of change in weight, smoking, sedentary behavior, cross-sectional areas of calf muscles and fat, 25-hydroxyvitamin D, parathyroid hormone, calcium, diabetes mellitus, and follow-up time. We found a significant association of “baseline GDF-15 × time” in models predicting cortical bone density and the mMOI in women, suggesting that the rates of decline in these bone parameters increased with higher GDF-15 (false discovery rate <0.05). Higher plasma levels GDF-15 predicted an accelerated decline in bone parameters in women, but was less associated in men. Furthermore studies are needed to understand the mechanisms underlying these sex differences.

  • Proteins in the pathway from high red blood cell width distribution to all-cause mortality

    Y Osawa, T Tanaka, RD Semba, G Fantoni, R Moaddel, J Candia, ...

    EBioMedicine 76, 103816 (eBioMedicine)  76   103816 2022.01

    Research paper (scientific journal), Single Work, Accepted,  ISSN  2352-3964

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    Background: The pathophysiological mechanisms underlying the association between red blood cell distribution width (RDW) and all-cause mortality are unknown. We conducted a data-driven discovery investigation to identify plasma proteins that mediate the association between RDW and time to death in community-dwelling adults. Methods: At baseline, 962 adults (women, 54·4%; age range, 21–98 years) participated in the InCHIANTI, “Aging in the Chianti Area” study, and proteomics data were generated from their plasma specimens. Of these, 623 participants had proteomics data available at the 9-year follow-up. For each visit, a total of 1301 plasma proteins were measured using SOMAscan technology. Complete data on vital status were available up to the 15-year follow-up period. Protein-specific exponential distribution accelerated failure time, and linear regression analyses adjusted for possible covariates were used for mortality and mediation analyses, respectively (survival data analysis). Findings: Baseline values of EGFR, GHR, NTRK3, SOD2, KLRF1, THBS2, TIMP1, IGFBP2, C9, APOB, and LRP1B mediated the association between baseline RDW and all-cause mortality. Changes in IGFBP2 and C7 over 9 years mediated the association between changes in RDW and 6-year all-cause mortality. Interpretation: Cellular senescence may contribute to the association between RDW and mortality. Funding: This study was funded by grants from the National Institutes of Health (NIH) and the National Institute on Aging (NIA) contract and was supported by the Intramural Research Program of the NIA, NIH. The InCHIANTI study was supported as a ‘targeted project’ by the Italian Ministry of Health and in part by the U.S. NIA.

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Papers, etc., Registered in KOARA 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 筋肉を起点とする身体の老化現象とその背景因子:国際共同研究


    科学研究費助成事業 基盤研究(B), Other, Principal investigator

  • 身体活動推進のための地域介入 多世代複合コホート研究の活用と政策展開


    日本学術振興会 , 科学研究費助成事業 基盤研究(B), Research grant, Coinvestigator(s)

  • Proteomic Signatures for Osteosarcopenia


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

Awards 【 Display / hide

  • Outstanding Poster Presentation Award

    2023.06, 12th IAGG Asia/Oceania Regional Congress 2023, Longitudinal Association Between Muscle Mass and Bone Mineral Density: Findings from Baltimore Longitudinal Study of Aging and National Institute for Longevity Sciences-Longitudinal Study of Aging

    Type of Award: Award from international society, conference, symposium, etc.


Courses Taught 【 Display / hide











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