Osawa, Yusuke



Graduate School of Health Management (Shonan Fujisawa)


Associate Professor (Non-tenured)

Other Affiliation 【 Display / hide

  • Sports Medicine Research Center, 兼担所員

Academic Degrees 【 Display / hide

  • Master of Science in Health Management, Keio University, Coursework, 2007.03

  • 博士(健康マネジメント学), Keio University, Coursework, 2011.08

    Effects of resistance training with whole-body vibration on muscle fitness and program design for untrained healthy adults


Research Areas 【 Display / hide

  • Sports science

  • Epidemiology and preventive medicine (Aging Exercise)

Research Keywords 【 Display / hide

  • Aging; Epidemiology; Proteomics; Sarcopenia


Papers 【 Display / hide

  • Physical activity and all-cause mortality and mediators of the association in the very old

    Y Osawa, Y Abe, M Takayama, Y Oguma, Y Arai

    Experimental Gerontology 150, 111374 (Experimental Gerontology)  150   111374 2021.07

    Research paper (scientific journal), Single Work, Accepted,  ISSN  0531-5565

     View Summary

    Background and objective: Physical activity (PA) confers protection to individuals from the risk of death. However, in the very old, the dose-response relationship between PA and all-cause mortality and the possible biological mediators of this association are less known. We investigated whether PA predicts 6-year all-cause mortality and what biomarkers mediate the association. Design: Prospective cohort data from the Tokyo Oldest Old Survey on Total Health study. Setting: Community-dwelling population. Participants: A total of 441 women and men aged over 85 years. Measurements: Questionnaire-based PA was assessed at baseline and 3-year and 6-year follow-up visits. Survival status was confirmed up to the 6-year follow-up visit (153 deaths, 34.7%). Data of plasma albumin, cholinesterase, NT-proBNP, interleukin-6, cystatin C, and HbA1c levels were collected. For mediation analysis for survival analysis, we used the baseline PA and biomarkers with Weibull distribution accelerated failure time model and linear regression model adjusted for age, sex, body mass index, smoking, education level, and Mini-Mental State Examination. Results: A curvilinear relationship was observed in the association between baseline PA and all-cause mortality. Compared to the inactive (0 METs*h/week), light amount of PA was associated with a lower risk of mortality. Compared to the highest tertile of PA (11.2 METs*h/week), higher PA did not reduce the risk of death. Circulation levels of albumin and cholinesterase mediated the association between baseline PA and all-cause mortality (proportion mediated, 54%, both; p < 0.05). Conclusions: Compared to completely inactive, light PA reduces the risk of all-cause mortality in the very old population. Mediation analysis suggests that protein synthesis in the liver may mediate the association between PA and all-cause mortality. Further studies are needed to understand the underlying association between PA, nutrition, and death.

  • Elevated plasma growth and differentiation factor 15 predicts incident anemia in older adults aged 60 years and older

    Y Yamaguchi, M Zampino, T Tanaka, S Bandinelli, Y Osawa, L Ferrucci, ...

    The Journals of Gerontology: Series A  2020.12

    Research paper (scientific journal), Single Work, Accepted,  ISSN  1079-5006

  • Longitudinal Associations Between Brain Volume and Knee Extension Peak Torque

    Y Osawa, Q Tian, Y An, SA Studenski, SM Resnick, L Ferrucci

    The Journals of Gerontology: Series A  2020.04

    Research paper (scientific journal), Single Work, Accepted,  ISSN  1079-5006

  • Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up.

    Osawa Y, Semba RD, Fantoni G, Candia J, Biancotto A, Tanaka T, Bandinelli S, Ferrucci L

    Aging cell (Aging Cell)  19 ( 4 ) e13132 2020.04

    Research paper (scientific journal), Single Work, Accepted,  ISSN  1474-9718

     View Summary

    © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. Introduction: Mobility disability is a powerful indicator of poor health in older adults. The biological and pathophysiological mechanism underlying the development of mobility disability remains unknown. This study conducted a data-driven discovery phase investigation to identify plasma proteins that predict the incidence of mobility disability in community-dwelling older adults without mobility disability at baseline. Methods: We investigated 660 women and men, aged 71.9 ± 6.0 (60–94) years, who participated in the Invecchiare in Chianti, “Aging in the Chianti Area” study and completed the 400-m walk at fast pace (400-m walk) at enrollment. Median follow-up time was 8.57 [interquartile, 3.20–9.08] years. SOMAscan technology was used to measure 1,301 plasma proteins at enrollment. The incident of mobility disability was defined as inability to complete the 400-m walk. Protein-specific Cox proportional hazard model was adjusted for sex, age, and other important covariates. Results: Plasma levels of 75 proteins predicted mobility disability (p '.05). Significant proteins were enriched for the KEGG “PI3K-Akt signaling,” “phagosomes,” and “cytokine–cytokine receptor interaction” pathways. After multiple comparison adjustment, plasma cathepsin S (CTSS; hazard ratio [HR] 1.33, 95% CI: 1.17, 1.51, q = 0.007), growth/differentiation factor 15 (GDF15; HR: 1.45, 95% CI: 1.23, 1.72, q = 0.007), and thrombospondin-2 (THBS2; HR: 1.44, 95% CI: 1.22, 1.69, q = 0.007) remained significantly associated with high risk of losing mobility. Conclusion: CTSS, GDF15, and THBS2 are novel blood biomarkers associated with new mobility disability in community-dwelling individuals. Overall, our analysis suggests that cellular senescence and inflammation should be targeted for prevention of mobility disability.

  • Plasma proteomic signature of the risk of developing mobility disability: A 9‐year follow‐up

    Y Osawa, RD Semba, G Fantoni, J Candia, A Biancotto, T Tanaka, ...

    Aging Cell, e13132  2020

    Research paper (scientific journal), Single Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • Proteomic Signatures for Osteosarcopenia


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 大澤 祐介, Grant-in-Aid for Scientific Research (C), Principal Investigator


Courses Taught 【 Display / hide











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