Yoshida, Tadashi

写真a

Affiliation

School of Medicine, Apheresis and Dialysis Center (Shinanomachi)

Position

Associate Professor

Profile 【 Display / hide

  • 慢性腎臓病の病態解明を慢性炎症の観点から解析を進めている。また、慢性腎臓病における心血管病変について発生機序の解明、新規治療法の開発を目的とした研究を行っている。

Other Affiliation 【 Display / hide

  • School of Medicine, 医学部総合診療教育センター, Associate Professor

Career 【 Display / hide

  • 1998.04
    -
    2001.09

    Keio University, School of Medicine, Internal Medicine, Instructor

  • 2001.09
    -
    2005.06

    University of Virginia, Department of Molecular Physiology and Biological Physics, Postdoctoral Fellow

  • 2005.07
    -
    2005.10

    University of Virginia, Robert M. Berne Cardiovascular Research Center, Instructor of Research

  • 2005.07
    -
    2005.10

    University of Virginia, Department of Molecular Physiology and Biological Physics, Instructor of Research

  • 2005.11
    -
    2008.08

    University of Virginia, The Robert M. Berne Cardiovascular Research Center, Assistant Professor of Research

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Academic Background 【 Display / hide

  • 1988.04
    -
    1994.03

    Keio University, School of Medicine

    University, Graduated

  • 1994.04
    -
    1998.03

    Keio University, School of Medicine, Department of Internal Medicine

    Japan, Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(医学), 慶應義塾大学, Coursework, 1998.03

    培養細胞およびヒトにおけるleptin発現分泌に対する各種ホルモンの影響

Licenses and Qualifications 【 Display / hide

  • 医師免許, 1994.05

  • 日本内科学会認定内科医, 1999.09

  • 日本内科学会総合内科専門医, 2011.12

  • 日本腎臓学会腎臓専門医, 2010.04

  • 日本腎臓学会腎臓指導医, 2015.04

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Research Areas 【 Display / hide

  • Kidney internal medicine

  • Molecular biology

Research Keywords 【 Display / hide

  • 血管石灰化

Research Themes 【 Display / hide

  • 慢性腎臓病における心血管病変について発生機序の解明・新規治療法の開発, 

    2010
    -
    Present

  • 血管平滑筋分化におけるエピジェネティック機構, 

    2001
    -
    Present

 

Books 【 Display / hide

  • これまでがワカる。これからがカワる。透析療法最前線

    YOSHIDA Tadashi, 東京医学社, 2018

    Scope: 透析患者の糖尿病管理~血糖コントロールの意義と指標~

  • Encyclopedia of Signaling Molecules, 2nd Edition

    YOSHIDA Tadashi, Springer, 2018

    Scope: Krüppel-like factor 4

  • 腎疾患・透析 最新の治療 2017-2019

    吉田 理, 林 松彦, 南江堂, 2017

    Scope: 高齢者に対する腎代替療法・治療上の注意点

  • 血栓性微小血管症診断・治療実践マニュアル

    吉田 理, 医薬ジャーナル社, 2016

    Scope: 血漿交換・血液透析

  • 目でみるトレーニング第3集

    YOSHIDA Tadashi, 医学書院, 2016

    Scope: 腎臓・泌尿器

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Papers 【 Display / hide

  • Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies

    Naoya Niwa, Tadashi Yoshida, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Matsuhiko Hayashi, Mototsugu Oya

    Clinical and Experimental Nephrology (Clinical and Experimental Nephrology)  22 ( 5 ) 1205 - 1212 2018

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  13421751

     View Summary

    © 2017, Japanese Society of Nephrology. Background: The suitable methods evaluating glomerular filtration rate (GFR) have not been established in patients undergoing radical nephrectomy (RN) or radical nephroureterectomy (RNU) due to urological malignancies in Japan as well as worldwide. Methods: We examined the relationship between creatinine clearance-based measured GFR (mGFR) versus estimated GFR (eGFR) calculated by 3 popular equations, 4-variable Modification of Diet in Renal Disease equation adjusted by Japanese correction coefficient (cmMDRD), 3-variable MDRD equation for Japanese population (eGFRcreat), and Chronic Kidney Disease-Epidemiology Collaboration equation adjusted by Japanese correction coefficient (cmCKD-EPI) in Japanese patients who had undergone RN or RNU due to renal cell carcinoma or upper tract urothelial carcinoma before and after surgery. Results: Among the 3 equations examined, eGFRcreat was the closest to mGFR, although each eGFR was significantly higher than mGFR in the pre-operative period. In the post-operative period, cmMDRD and eGFRcreat, but not cmCKD-EPI, were comparable to mGFR. Each of eGFR was significantly correlated with mGFR in both the pre-operative and post-operative periods. Similar results were obtained by the subanalysis of the patients with pre-operative mGFR of < 60 mL/min/1.73 m2. Results of κ statistics also showed that eGFRcreat was most appropriate to estimate GFR both before and after heminephrectomy, when cut-off value of GFR of < 60 mL/min/1.73 m2 was used. Conclusion: Results of the present study suggest that eGFRcreat is likely to be the most appropriate equation for patients undergoing RN or RNU due to urological malignancies. However, more precise equations will be required for accurately estimating GFR.

  • Acceptance situation of HIV patients in Japanese dialysis facilities: Questionnaire survey by the Infection Survey Subcommmittee

    Ayumi Yoshifuji, Munekazu Ryuzaki, Yasuhiko Ito, Norio Ohmagari, Yoshihiko Kanno, Toshio Shinoda, Yaoko Takano, Isao Tsukamoto, Kazuhiko Hora, Yasushi Nakazawa, Naoki Hasegawa, Tadashi Yoshida, Shu Wakino, Yoshiaki Takemoto, Hidetomo Nakamoto

    Renal Replacement Therapy  2018

    Research paper (scientific journal), Joint Work, Accepted

  • Expanding phenotype of nephronophthisis-related ciliopathy: an elderly patient with homozygous RPGRIP1L mutation

    Takahisa Kawaguchi, Tadashi Yoshida, Junichi Hirahashi, Tomoko Uehara, Toshiki Takenouchi, Kenjiro Kosaki, Hiroshi Itoh, Matsuhiko Hayashi

    Nephron (Nephron)  140 ( 1 ) 74 - 78 2018

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  16608151

     View Summary

    © 2018 S. Karger AG, Basel. Nephronophthisis-related ciliopathies (NPHP-RC) are autosomal recessive disorders characterized by renal corticomedullary cysts with the extrarenal symptoms. Typically, patients with NPHP-RC reach end-stage kidney disease (ESKD) before the age of 30 years. We herein report a Japanese woman with NPHP-RC who had unusually delayed progression to ESKD after 6 decades. She exhibited liver dysfunction at the age of 23 years. She also showed mild renal dysfunction at the age of 43 years. Ultrasonography revealed bilateral multiple renal cysts with loss of corticomedullary differentiation. Her liver and renal functions gradually deteriorated. She was diagnosed with liver fibrosis as a result of biopsy, and initiated the maintenance hemodiafiltration therapy for ESKD at the age of 61 years. Because of a unique combination of multiple renal cysts and liver fibrosis, ciliopathy was suspected and medical exome analysis was performed. A novel homozygous missense mutation was identified in RPGRIP1L (c.1810G>A p.Glu604Lys), a causative gene for NPHP-RC. To the best of our knowledge, this patient is the oldest one who progressed to ESKD in NPHP-RC. Our case illustrates that NPHP-RC should be included in the differential diagnosis of the patient with corticomedullary polycystic kidneys accompanied by the extrarenal organ involvements, even if the patient is elderly.

  • 腎線維化に対する神経堤由来線維芽細胞におけるNF-kBの役割

    吉田 理

    日本透析医会雑誌 33   163 - 166 2018

    Research paper (scientific journal), Single Work, Accepted

  • 慢性腎臓病における平滑筋での慢性炎症と血管石灰化

    吉田 理

    日本透析医会雑誌 33 2018

    Research paper (scientific journal), Single Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 慢性透析患者における透析見合わせに関する現状調査

    山口伸子, 吉田 理, 平橋淳一, 新見たづる, 廣川美穂子, 斉藤みわ, 中野玲子, 大場美保, 浦澤智佐

    第21回日本腎不全看護学会学術集会・総会 (長野) , 2018.11, Oral Presentation(general)

  • A novel I551F mutant of Na+/HCO3- cotransporter NBCe1 has cytosolic retention and diminishes transport activity

    Osamu Yamazaki, Maho Yamashita, Jinping Li, Tadashi Yoshida, Junichi Hirahashi, Shigeru Shibata, and Matsuhiko Hayashi

    51st Annual Meeting of the American Society of Nephrology. (San Diego, CA, USA) , 2018.10, Poster (general)

  • 進行性腎細胞癌に対し分子標的治療を行った維持血液透析患者の検討

    水野隆一, 環 聡, 森田伸也, 吉田 理, 大家基嗣

    第63回日本透析医学会学術集会・総会 (神戸) , 2018.07, Poster (general)

  • 透析患者の糖尿病管理

    吉田 理

    第63回日本透析医学会学術集会・総会 (神戸) , 2018.07, Symposium, Workshop, Panelist (nomination)

  • 化膿性脊椎炎と化膿性腸腰筋炎を合併した人工血管内シャント感染の1例

    村上哲史, 吉田 理, 環 聡, 森田伸也, 大家基嗣, 林 松彦

    第63回日本透析医学会学術集会・総会 (神戸) , 2018.06, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 抑制的なヒストンメチル化修飾への介入による血管石灰化の制御

    2021.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 吉田 理, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • 血管石灰化における平滑筋細胞でのエピジェネティック機構

    2018.04
    -
    2019.03

    日本透析医会, 公募研究助成, Research grant, Principal Investigator

  • 慢性腎臓病における血管内皮の炎症と中膜石灰化の関係

    2017.03
    -
    2018.03

    日本透析医会, 公募研究助成, Research grant, Principal Investigator

  • Endothelial Kruppel-like factor 4 metidates the protective effect of statins against ischemic AKI

    2016.06

    Keio Gijuku Academic Development Funds, Research grant, Principal Investigator

  • 血管平滑筋細胞の表現型制御による血管石灰化治療法の開発

    2016.04
    -
    2019.03

    Grant-in-Aid for Scientific Research, Research grant, Principal Investigator

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Intellectual Property Rights, etc. 【 Display / hide

  • 25-hydroxyvitamin D3-1a-hydroxylase and DNA encoding the hydroxylase

    Application No.: United States Patent 6274359  2001.08 

    Patent, Joint

Awards 【 Display / hide

  • American Heart Association ATVB Merit Award for Young Investigators

    2007.11, American Heart Association

  • 慶應義塾大学医学部三四会賞

    1999.11, 慶應義塾大学医学部

 

Courses Taught 【 Display / hide

  • CLINICAL ENGINEERING AND SAFETY CONTROL IN HEALTH CARE

    2021

  • CLINICAL ENGINEERING AND SAFETY CONTROL IN HEALTH CARE

    2020

  • GENERAL MEDICINE

    2019

  • CLINICAL ENGINEERING AND SAFETY CONTROL IN HEALTH CARE

    2019

Courses Previously Taught 【 Display / hide

  • 腎臓内科学

    Keio University, 2018

  • 総合診療医学

    Keio University, 2018

  • General Medicine

    Keio University, 2015, Full academic year, Major subject, Lecture

 

Memberships in Academic Societies 【 Display / hide

  • 日本内科学会

     
  • 日本腎臓学会

     
  • 日本内分泌学会

     
  • 日本透析医学会

     
  • 日本高血圧学会

     

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Committee Experiences 【 Display / hide

  • 2016.06
    -
    Present

    評議員, 日本透析医学会

  • 2015.04
    -
    Present

    評議員, 日本内分泌学会

  • 2013.04
    -
    Present

    評議員, 日本腎臓学会