MATSUZAKI Juntaro

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy Division of Pharmacotherapeutics (Shiba-Kyoritsu)

Position

Associate Professor

Related Websites

External Links

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Coursework, 2013

 

Research Areas 【 Display / hide

  • Life Science / Tumor diagnostics and therapeutics

  • Life Science / Gastroenterology

Research Keywords 【 Display / hide

  • cancer

  • microRNA

  • extracellular RNA

 

Books 【 Display / hide

  • テクノロジーロードマップ2023-2032 医療・健康・食農編

    松﨑潤太郎, 落谷孝広, 日経BP, 2023.03

    Scope: 多がん早期検出

  • 疾患バイオマーカーとしてのマイクロRNAと診断応用

    松﨑潤太郎, 落谷孝広, シーエムシー出版, 2022.06

  • 消化器系疾患(2). Principal Pharmacotherapy (改訂3版)

    松﨑潤太郎, ネオメディカル, 2022.04

  • 胃・十二指腸潰瘍. 看護基礎教育テキスト ナーシング・グラフィカ「疾患と看護シリーズ」『3 消化器疾患と看護』

    松﨑潤太郎, 鈴木秀和, メディカ出版, 2019.12

  • テクノロジーロードマップ2019-2028 医療・健康・食農編

    松﨑潤太郎, 落谷孝広, 日経BP, 2019.03

    Scope: がん早期診断

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Papers 【 Display / hide

  • Identifying high-grade serous ovarian carcinoma–specific extracellular vesicles by polyketone-coated nanowires

    Yokoi A, Ukai M, Yasui T, Inokuma Y, Hyeon-Deuk K, Matsuzaki J, Yoshida K, Kitagawa M, Chattrairat K, Iida M, Shimada T, Manabe Y, Chang IY, Asano-Inami E, Koya Y, Nawa A, Nakamura K, Kiyono T, Kato T, Hirakawa A, Yoshioka Y, Ochiya T, Hasegawa T, Baba Y, Yamamoto Y, Kajiyama H

    Science Advances 9 ( 27 ) eade6958 2023.07

    Research paper (scientific journal), Joint Work, Accepted

  • Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver.

    Tsugawa H, Ohki T, Tsubaki S, Tanaka R, Matsuzaki J, Suzuki H, Hozumi K

    PLoS pathogens 19 ( 6 ) e1011139 2023.06

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1553-7366

  • A validation study for the utility of serum microRNA as a diagnostic and prognostic marker in patients with osteosarcoma.

    Araki Y, Asano N, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Higuchi T, Abe K, Taniguchi Y, Yonezawa H, Morinaga S, Asano Y, Yoshida T, Hanayama R, Matsuzaki J, Ochiya T, Kawai A, Tsuchiya H

    Oncology letters 25 ( 6 ) 222 2023.06

    Joint Work, Accepted,  ISSN  1792-1074

  • Serum microRNAs as new criteria for referral to early palliative care services in treatment-naïve advanced cancer patients.

    Miura T, Mitsunaga S, Matsuzaki J, Takizawa S, Kato K, Ochiai A, Ochiya T

    Oncotarget 13   1341 - 1349 2022.12

    Research paper (scientific journal), Joint Work, Accepted

  • Response to letter regarding: development of plasma ghrelin level as a novel marker for gastric mucosal atrophy after <i>Helicobacter pylori</i> eradication.

    Mori H, Matsuzaki J, Suzuki H

    Annals of medicine 54 ( 1 ) 856 - 857 2022.12

    Research paper (scientific journal), Joint Work,  ISSN  0785-3890

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 医薬連携 薬剤師の質問に何でも答えます!Helicobacter pylori感染症(第3回) 医師からの処方で一次除菌,二次除菌時の酸分泌抑制薬がボノプラザン以外のPPIの場合は,薬剤師はどのようにすべきでしょうか?

    荒谷 優希, 松崎 潤太郎, 齋藤 義正

    Helicobacter Research ((株)先端医学社)  27 ( 2 ) 242 - 244 2023.12

    ISSN  1342-4319

     View Summary

    一次除菌,二次除菌ともにボノプラザンは従来のプロトンポンプ阻害薬(PPI)に比べて高い除菌成功率を示します.除菌に用いる酸分泌抑制薬にはボノプラザンの選択が最適でしょう.(著者抄録)

  • 【上部消化管疾患の残された課題】バレット食道および食道腺がんの疫学と病態

    鈴木 志帆, 松崎 潤太郎, 齋藤 義正

    Progress in Medicine ((株)ライフ・サイエンス)  43 ( 9 ) 761 - 765 2023.09

    ISSN  0287-3648

  • 高異型度漿液性卵巣癌に対するPARP阻害薬効果予測としての細胞外小胞DNA上コピー数多型解析

    植草 良輔, 横井 暁, 吉田 康将, 北川 雅美, 芳川 修久, 松崎 潤太郎, 山本 雄介, 梶山 広明

    日本婦人科腫瘍学会学術講演会プログラム・抄録集 ((公社)日本婦人科腫瘍学会)  65回   296 - 296 2023.07

  • 「消化管疾患と性差」 慢性便秘症患者における症状・QOL・治療反応の性差の検討

    森 英毅, 正岡 建洋, 松崎 潤太郎, 水上 健, 金井 隆典

    日本高齢消化器病学会誌 ((NPO)日本高齢消化器病学会)  26 ( 1 ) 150 - 150 2023.07

    ISSN  1881-0837

  • 基礎研究-Helicobacter属細菌の病原性 がん幹細胞様細胞におけるH.pylori除菌後のCagA蓄積性が細胞に与える影響

    森 英毅, 鈴木 秀和, 津川 仁, 松崎 潤太郎, 正岡 建洋, 金井 隆則

    日本ヘリコバクター学会学術集会プログラム・抄録集 ((一社)日本ヘリコバクター学会)  29回   82 - 82 2023.06

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Presentations 【 Display / hide

  • ヒト肝細胞由来肝前駆細胞(hCLiP)由来sEVの肝線維化改善効果の検討

    山口智子, 松崎潤太郎, 勝田毅, 徳田乃唯, 檀裕治, 木村真規, 落谷孝広, 齋藤義正

    第10回日本細胞外小胞学会学術集会, 

    2023.10

    Poster presentation

  • 肺上皮細胞におけるCOPB2の細胞外小胞への分泌機構の解明

    檀裕治, 松崎潤太郎,山口智子, 及川千尋, 木村真規, 藤田雄, 落谷孝広, 齋藤義正

    第10回日本細胞外小胞学会学術集会, 

    2023.10

    Poster presentation

  • 胆管がんにおける19番染色体マイクロRNAクラスター発現の重要性

    松﨑潤太郎, 葉子祥, 村松俊英, 齋藤義正

    第82回日本癌学会学術総会. 横浜, 

    2023.09

    Oral presentation (general)

  • 加齢による腸内細菌-宿主応答の変化に注目した新規発がんリスクバイオマーカーの探索

    松﨑潤太郎, 津川仁, 中山淳, 山本雄介, 加藤健, 大田信行, 大嶋一輝, 勝田菜友, 吉岡祐亮, 落谷孝広, 齋藤義正

    第30回日本がん予防学会総会, 

    2023.09

    Oral presentation (general)

  • 細胞外小胞で創薬はできそうなのか

    松﨑 潤太郎

    第3回反分野的生物医療学会学術集会, 

    2023.09

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Comprehensive elucidation of the mechanisms of circulating microRNA variability during pancreatic carcinogenesis

    2022.04
    -
    2025.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

     View Summary

    膵がんのように早期診断技術開発が待望される腫瘍において、血中マイクロRNA (miRNA)診断の実用化が期待されている。多くの臨床検体の解析から、そのコンセプトの正しさは実証されているが、血中miRNAによってなぜ膵がんが診断できるのか証明しきれていない。特に膵腫瘍の発生によって周辺の細胞や免疫細胞などが反応し、分泌するmiRNAが変化することも、血中miRNAに大きく影響している可能性がある。本研究はこれらの点を考慮し、マウスで膵発がん過程での血中miRNA変化を追跡し、その生理学的意義を明らかにすることで、実臨床における血中miRNA診断実用化に必須となる基盤的知見を提供する。

  • CRISPR-Cas9 based screening for essential tumor suppressors in liver carcinogenesis

    2017.06
    -
    2020.03

    National Cancer Center Japan, Yamamoto Yusuke, Grant-in-Aid for Challenging Research (Exploratory), No Setting

     View Summary

    A large number of research projects identified genetic mutations in the process of carcinogenesis, and there have been some useful findings of studies using cancer cell lines. With next generation sequencing, genetic variants in a variety of cancers have been identified and shown to have an impact on carcinogenesis; however, it is still unclear how the mutations essentially influenced the carcinogenesis and their metastatic potential. In this research project, we introduced and quantitatively analyzed the contribution of genetic mutations involved in the carcinogenic process by CRISPR-Cas9, in order to knockout the tumor suppressor genes in primary epithelial cells, and examined the effect of each gene on carcinogenesis. Also, we tried to recapitulate the multi-step carcinogenesis in vitro. This study enables us to accurately reflect and reproduce genomic aberrations in normal cells, and to achieve validation of the actual function of driver gene mutations.

  • Identification of circulating microRNAs for the detection of early stage pancreatic cancer

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Matsuzaki Juntaro, Grant-in-Aid for Scientific Research (C), Principal investigator

     View Summary

    We established the culturing method of pancreatic progenitor cells by chemical direct reprogramming of pancreatic exocrine cells isolated from mouse pancreas. We then investigated the alteration in intracellular and extracellular miRNAs during the exposure to bile acid, which is a potential cause of pancreatic carcinogenesis. As a result, several miRNAs including miR-296-5p and miR-135a-3p were identified as miRNAs whose secretion into the cell culture supernatant was enhanced. These miRNAs are expected to be biomarkers for the early-stage pancreatic cancer.

  • Generation of hepatic progenitor cells from human hepatocytes using small molecules

    2016.04
    -
    2018.03

    National Cancer Center Japan, KATSUDA Takeshi, OCHIYA Takahiro, MATSUZAKI Juntaro, SAITO Yoshimasa, TAKEUCHI Atsuko, Grant-in-Aid for Young Scientists (B), No Setting

     View Summary

    Using small molecule inhibitors, we recently reported that rodent mature hepatocytes can be reprogrammed into progenitor-like phenotype with repopulative capacity. In this study, using the same strategy, we demonstrated that hepatic progenitor cells can be induced from human infant hepatocytes. These cells, named human chemically induced progenitors (hCLiPs), exhibited significant repopulative capacity in injured mouse livers following transplantation, and contributed to reconstruction of the normal liver architecture. We also found that hCLiPs can be redifferentiated into mature hepatocytes in vitro with hepatic inducible factors. These redifferentiated cells can be induced to exhibit cytochrome P450 (CYP) enzymatic activities in response to the CYP inducing molecules with the efficiency comparable with that of primary hepatocytes. Thus, this study contributes to progress in the field of liver cell transplantation therapy and pharmacological research field.

  • Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma

    2014.04
    -
    2016.03

    Keio University, Matsuzaki Juntaro, TSUGAWA Hitoshi, SUZUKI Hidekazu, Grant-in-Aid for Young Scientists (B), No Setting

     View Summary

    Esophageal adenocarcinoma, which is rapidly increasing in Western countries, is one of the complications of gastroesophageal reflux disease. Bile reflux and central obesity are major risk factors for esophageal adenocarcinoma. In general, plasma adiponectin levels are decreased through the progression of central obesity. We had reported that bile acids contribute to carcinogenesis through the activation of nuclear bile acid receptor (FXR) and the enhancement of miR-221/222. Herein, we identified that miR-221/222 enhance the expression of COX-2 in esophageal epithelial cells. On the other hand, COX-2 expression was suppressed during exposure to adiponectin receptor agonist. These results suggest adiponectin receptor agonist might work as a chemopreventive agent for esophageal adenocarcinoma among high-risk individuals with central obesity.

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Awards 【 Display / hide

  • 日本癌学会奨励賞

    2020

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • the 15th Korea-Japan Joint Symposium on Helicobacter infection Young Investigator Award

    2018

    Type of Award: Award from international society, conference, symposium, etc.

  • United European Gastroenterology Week (UEGW) 2016 Poster of Excellence

    2016

    Type of Award: Award from international society, conference, symposium, etc.

  • 第18回日本神経消化器病学会・第6回IBS研究会・第84回消化器心身医学研究会・第10回機能性ディスペプシア研究会合同学術集会 並木賞

    2016

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • 4th Biennial Congress of Asian Neurogastroenterology & Motility Association (ANMA) Best Poster Presentation Award

    2015

    Type of Award: Award from international society, conference, symposium, etc.

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Courses Taught 【 Display / hide

  • STUDY OF MAJOR FIELD: (PHARMACOTHERAPEUTICS)

    2023

  • SEMINAR:(PHARMACOTHERAPEUTICS)

    2023

  • RESEARCH FOR BACHELOR'S THESIS 1

    2023

  • PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

    2023

  • PHYSICAL ASSESSMENT AND DIAGNOSTIC IMAGING

    2023

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Memberships in Academic Societies 【 Display / hide

  • 日本内科学会, 

    2005
    -
    Present

Committee Experiences 【 Display / hide

  • 2024.01
    -
    Present

    日本消化器病学会関東支部評議員

  • 2023.01
    -
    Present

    日本癌学会評議員

  • 2019
    -
    Present

    日本微小循環学会評議員

  • 2018
    -
    Present

    日本ヘリコバクター学会代議員