KEIO RESEARCHERS INFORMATION SYSTEM

Other Affiliation 【 Display / hide 】

Other Affiliation 【 Display / hide 】

• Keio University, Human Biology- Microbiome- Quantum Research Center (Bio2Q), Affiliated PI

• Keio University School of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Concurrent Professor

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, Keio University, Coursework, 2013

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Tumor diagnostics and therapeutics

• Life Science / Gastroenterology

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• cancer

• microRNA

• extracellular RNA

Books 【 Display / hide 】

Books 【 Display / hide 】

• テクノロジーロードマップ2023-2032 医療・健康・食農編

  松﨑潤太郎, 落谷孝広, 日経BP, 2023.03

  Scope: 多がん早期検出

• 疾患バイオマーカーとしてのマイクロRNAと診断応用

  松﨑潤太郎, 落谷孝広, シーエムシー出版, 2022.06

• 消化器系疾患(2). Principal Pharmacotherapy (改訂3版)

  松﨑潤太郎, ネオメディカル, 2022.04

• 胃・十二指腸潰瘍. 看護基礎教育テキスト ナーシング・グラフィカ「疾患と看護シリーズ」『3 消化器疾患と看護』

  松﨑潤太郎, 鈴木秀和, メディカ出版, 2019.12

• テクノロジーロードマップ2019-2028 医療・健康・食農編

  松﨑潤太郎, 落谷孝広, 日経BP, 2019.03

  Scope: がん早期診断

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Large-scale Genomic Landscape and Clinical Outcomes of De Novo and Treatment-emergent Neuroendocrine Prostate Cancer.

  Iida K, Tashiro K, Urabe F, Matsui Y, Urabe Y, Ishikawa T, Matsuzaki J, Yoshihara K, Kimura T, Saito Y

  European urology open science 90   57 - 68 2026.08

  Joint Work,  ISSN  2666-1691

  • Access to Document (DOI)

• Methods to build and maintain effective clinician-patient relationships for adults with disorders of gut-brain interaction (DGBI): a systematic review.

  Mihara H, Matsuzaki J, Okugawa T, Oshima T, Asakawa A, Kamiya T, Kessoku T, Suzuki H, Nakamura K, Hojo M, Mori H, Yamamoto T, Tanaka F, Futagami S, Haruma K, Joh T, Kusano M, Yakabi K

  Journal of gastroenterology  2026.06

  Joint Work,  ISSN  0944-1174

  • Access to Document (DOI)

• Cold Sensation and Gastric Accommodation in Functional Dyspepsia: An Exploratory Study of Autonomic Function

  Digestion  2026.06

  Joint Work

  • Access to Document (DOI)

• Impact of Isolation Techniques on the Content of Small Extracellular Vesicles.

  Su Y, Visan KS, Voss S, Prieto-Vila M, Matsuzaki J, Chan JYK, Yam JWP, Möller A

  Journal of extracellular vesicles 15 ( 6 ) e70290 2026.06

  Joint Work

  • Access to Document (DOI)

• DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High-Grade Serous Ovarian Carcinoma.

  Uekusa R, Yokoi A, Ukai M, Yoshida K, Chattrairat K, Yasui T, Inokuma Y, Kitagawa M, Asano-Inami E, Yoshihara M, Tamauchi S, Yoshikawa N, Niimi K, Matsuzaki J, Ochiya T, Sood AK, Yamamoto Y, Kajiyama H

  Journal of extracellular vesicles 15 ( 5 ) e70308 2026.05

  Joint Work

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Development of a new blood-based test using COPB2-positive extracellular vesicles to detect lung cancer

  Matsuzaki, Juntaro

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2023

• Functional analysis of extracellular miRNAs as indicators of liver fibrosis

  Matsuzaki, Juntaro

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2022

• Identification of circulating microRNAs for the detection of early stage pancreatic cancer

  Matsuzaki, Juntaro

  科学研究費補助金研究成果報告書 2021

• Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma

  Matsuzaki, Juntaro

  科学研究費補助金研究成果報告書 2015

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 転移性去勢抵抗性前立腺癌における包括的ゲノム解析とBRCA1/2病的バリアントの臨床的意義(Comprehensive genomic profiling landscape and clinical outcomes of BRCA1/2 pathogenic variants in metastatic castration-resistant prostate cancer)

  占部 文彦, 飯田 和樹, 松井 裕也, 田代 康次郎, 吉原 健太郎, 占部 雄聖, 石川 隆昭, 松崎 潤太郎, 齋藤 義正, 木村 高弘

  日本泌尿器科学会総会 ((一社)日本泌尿器科学会総会事務局)  113回   AOP - 02 2026.04

• Klebsiella pneumoniae由来菌体外膜小胞によるLPS誘導性炎症応答の拮抗作用とその病理学的意義(K. pneumoniae-derived EVs antagonize LPS-induced inflammation and exhibit a pathologic involvement)

  豊元 柊弥, 椿 翔吾, 松崎 潤太郎, 澤 智裕, 津川 仁

  日本細菌学雑誌 (日本細菌学会)  81 ( 1 ) 42 - 42 2026.03

  ISSN  0021-4930

• 多がん早期検出(MCED)検査

  山本 透蒼, 松崎 潤太郎

  腫瘍内科 ((有)科学評論社)  37 ( 2 ) 192 - 196 2026.02

  ISSN  1881-6568

• アルコール性ケトアシドーシスを契機に発症した黒色食道(急性壊死性食道炎)の一例

  宇佐美 友那, 森 英毅, 安藤 裕子, 正岡 建洋, 松崎 潤太郎, 齋藤 義正, 金井 隆典

  日本消化器病学会関東支部例会プログラム・抄録集 (日本消化器病学会-関東支部)  387回   28 - 28 2025.12

• 膵管前駆細胞におけるKrasG12D変異細胞が誘導するmiRNAの発現変動解析(Analysis of miRNA Expression Changes Induced by KrasG12D Mutant Cells in Pancreatic Ductal Progenitor Cells)

  大島 優人, 松崎 潤太郎, 及川 千尋, 柴垣 里奈, 是枝 泰介, 落谷 孝広, 勝田 毅, 齋藤 義正

  日本癌学会総会記事 ((一社)日本癌学会)  84回   1732 - 1732 2025.09

  ISSN  0546-0476

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 機能性消化管障害診療の最適化への取り組み

  松崎潤太郎

  [Domestic presentation]  日本消化器病学会関東支部 第45回教育講演会, 

  2024.11

  , 

  Public lecture, seminar, tutorial, course, or other speech

• 生物界を飛びこえる細胞外RNA

  松崎潤太郎

  [Domestic presentation]  第4回反分野的生物医療学会学術集会, 

  2024.09

  , 

  Oral presentation (general)

• Checklist for blood sample collection when developing clinical application of blood EV biomarkers

  Matsuzaki J

  [International presentation]  ISEV Workshop:Blood EVs 2024, 

  2024.09

  , 

  Oral presentation (invited, special)

• Frontiers of Next-Generation Cancer Testing Technology Using microRNAs

  Matsuzaki J

  [Domestic presentation]  第83回日本癌学会学術総会, 

  2024.09

  , 

  Symposium, workshop panel (nominated)

• 細胞外小胞研究と毒素研究のアナロジーを探る

  松崎潤太郎

  [Domestic presentation]  第70回トキシンシンポジウム, 

  2024.08

  , 

  Oral presentation (invited, special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Elucidating the bacterial-host response via RNA delivery

  2026.04

  -

  2028.03

  Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (A), No Setting

  　View Summary

  細菌叢と疾患の関連において、細菌由来細胞外小胞に含まれるRNAの機能研究は未開拓である。応募者は、細菌RNAがマクロファージを変容させ肝発がんに寄与することを実証した。本研究では、細菌RNAによる宿主細胞撹乱と発がんの分子機序を包括的に解明し、細菌・宿主・がんの関係に新機軸を構築する。これにより発がん機構の理解を拡張し、革新的な予防・治療戦略の創出を目指す。

• Comprehensive elucidation of the mechanisms of circulating microRNA variability during pancreatic carcinogenesis

  2022.04

  -

  2025.03

  Grants-in-Aid for Scientific Research, Matsuzaki Juntaro, Grant-in-Aid for Scientific Research (B), No Setting

  　View Summary

  For tumors such as pancreatic cancer, where early diagnostic technology is highly anticipated, it is hoped that circulating microRNA (miRNA) diagnosis will become practical. We used CRISPR/Cas9 to perform gene editing on pancreatic progenitor cells established from the primary culture of mouse pancreatic ducts. We created a pancreatic multistage carcinogenesis cell line in which mutations in Kras, Cdkn2a, Tp53, and Smad4 were introduced. Extracellular vesicles were collected from the culture supernatant of each cell line, and miRNA-seq was used to analyze miRNA profiles comprehensively. The cell lines were transplanted into the pancreas of nude mice, and changes in miRNA expression in mouse serum were compared, identifying miRNAs that changed in the blood due to the acquisition of Kras mutations.

• CRISPR-Cas9 based screening for essential tumor suppressors in liver carcinogenesis

  2017.06

  -

  2020.03

  National Cancer Center Japan, Yamamoto Yusuke, Grant-in-Aid for Challenging Research (Exploratory), No Setting

  　View Summary

  A large number of research projects identified genetic mutations in the process of carcinogenesis, and there have been some useful findings of studies using cancer cell lines. With next generation sequencing, genetic variants in a variety of cancers have been identified and shown to have an impact on carcinogenesis; however, it is still unclear how the mutations essentially influenced the carcinogenesis and their metastatic potential. In this research project, we introduced and quantitatively analyzed the contribution of genetic mutations involved in the carcinogenic process by CRISPR-Cas9, in order to knockout the tumor suppressor genes in primary epithelial cells, and examined the effect of each gene on carcinogenesis. Also, we tried to recapitulate the multi-step carcinogenesis in vitro. This study enables us to accurately reflect and reproduce genomic aberrations in normal cells, and to achieve validation of the actual function of driver gene mutations.

• Identification of circulating microRNAs for the detection of early stage pancreatic cancer

  2017.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Matsuzaki Juntaro, Grant-in-Aid for Scientific Research (C), Principal investigator

  　View Summary

  We established the culturing method of pancreatic progenitor cells by chemical direct reprogramming of pancreatic exocrine cells isolated from mouse pancreas. We then investigated the alteration in intracellular and extracellular miRNAs during the exposure to bile acid, which is a potential cause of pancreatic carcinogenesis. As a result, several miRNAs including miR-296-5p and miR-135a-3p were identified as miRNAs whose secretion into the cell culture supernatant was enhanced. These miRNAs are expected to be biomarkers for the early-stage pancreatic cancer.

• Generation of hepatic progenitor cells from human hepatocytes using small molecules

  2016.04

  -

  2018.03

  National Cancer Center Japan, KATSUDA Takeshi, OCHIYA Takahiro, MATSUZAKI Juntaro, SAITO Yoshimasa, TAKEUCHI Atsuko, Grant-in-Aid for Young Scientists (B), No Setting

  　View Summary

  Using small molecule inhibitors, we recently reported that rodent mature hepatocytes can be reprogrammed into progenitor-like phenotype with repopulative capacity. In this study, using the same strategy, we demonstrated that hepatic progenitor cells can be induced from human infant hepatocytes. These cells, named human chemically induced progenitors (hCLiPs), exhibited significant repopulative capacity in injured mouse livers following transplantation, and contributed to reconstruction of the normal liver architecture. We also found that hCLiPs can be redifferentiated into mature hepatocytes in vitro with hepatic inducible factors. These redifferentiated cells can be induced to exhibit cytochrome P450 (CYP) enzymatic activities in response to the CYP inducing molecules with the efficiency comparable with that of primary hepatocytes. Thus, this study contributes to progress in the field of liver cell transplantation therapy and pharmacological research field.

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 慶應義塾大学薬学部長賞

  2024.04

  Type of Award： Keio commendation etc.

• 日本癌学会奨励賞

  2020

  Type of Award： Award from Japanese society, conference, symposium, etc.

• the 15th Korea-Japan Joint Symposium on Helicobacter infection Young Investigator Award

  2018

  Type of Award： Award from international society, conference, symposium, etc.

• United European Gastroenterology Week (UEGW) 2016 Poster of Excellence

  2016

  Type of Award： Award from international society, conference, symposium, etc.

• 第18回日本神経消化器病学会・第6回IBS研究会・第84回消化器心身医学研究会・第10回機能性ディスペプシア研究会合同学術集会 並木賞

  2016

  Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• CLINICAL EXPERIENCE PROGRAM

  2026

• SEMINAR(RESEARCH CENTER FOR DRUG DISCOVERY)

  2026

• RESEARCH FOR BACHELOR'S THESIS 1

  2026

• SPECIAL LECTURES BY GUEST SPEAKERS

  2026

• EARLY EXPOSURE TO INDUSTRY

  2026

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2025.06

  -

  Present

  Progress of Digestive Endoscopy, 編集委員

• 2025.01

  -

  Present

  Cancer Science, Associate Editor

• 2024.04

  -

  Present

  日本細胞外小胞学会　理事

• 2024.01

  -

  Present

  日本消化器病学会　関東支部　評議員

• 2023.01

  -

  Present

  日本癌学会　評議員

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