KEIO RESEARCHERS INFORMATION SYSTEM

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, Keio University, Coursework, 2013

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Tumor diagnostics and therapeutics

• Life Science / Gastroenterology

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• cancer

• microRNA

• extracellular RNA

Books 【 Display / hide 】

Books 【 Display / hide 】

• テクノロジーロードマップ2023-2032 医療・健康・食農編

  松﨑潤太郎, 落谷孝広, 日経BP, 2023.03

  Scope: 多がん早期検出

• 疾患バイオマーカーとしてのマイクロRNAと診断応用

  松﨑潤太郎, 落谷孝広, シーエムシー出版, 2022.06

• 消化器系疾患(2). Principal Pharmacotherapy (改訂3版)

  松﨑潤太郎, ネオメディカル, 2022.04

• 胃・十二指腸潰瘍. 看護基礎教育テキスト ナーシング・グラフィカ「疾患と看護シリーズ」『3 消化器疾患と看護』

  松﨑潤太郎, 鈴木秀和, メディカ出版, 2019.12

• テクノロジーロードマップ2019-2028 医療・健康・食農編

  松﨑潤太郎, 落谷孝広, 日経BP, 2019.03

  Scope: がん早期診断

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Circulating serum miRNAs predict response to platinum chemotherapy in high-grade serous ovarian cancer.

  Suzuki K, Yokoi A, Matsuzaki J, Yoshida K, Yamamoto Y, Kato T, Ishikawa M, Ochiya T, Kajiyama H

  Cancer medicine 13 ( 22 ) e70251 2024.11

  Joint Work

  • Access to Document (DOI)

• Macrophage-depleted young mice are beneficial in vivo models to assess the translocation of Klebsiella pneumonia from the gastrointestinal tract to the liver in the elderly.

  Tsugawa H, Tsubaki S, Tanaka R, Nashimoto S, Imai J, Matsuzaki J, Hozumi K

  Microbes and infection 26 ( 8 ) 105371 2024.06

  Joint Work,  ISSN  1286-4579

  • Access to Document (DOI)

• Potential utility of pretreatment serum miRNAs for optimal treatment selection in advanced high-grade serous ovarian cancer.

  Uehara T, Matsuzaki J, Yoshida H, Ogawa Y, Miura J, Fujimiya H, Yamamoto Y, Kawauchi J, Takizawa S, Yonemori K, Sakamoto H, Kato K, Ishikawa M, Ochiya T

  Japanese journal of clinical oncology 54 ( 8 ) 917 - 925 2024.04

  Joint Work,  ISSN  0368-2811

  • Access to Document (DOI)

• Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy.

  Kondo N, Kinouchi T, Natsumeda M, Matsuzaki J, Hirata E, Sakurai Y, Okada M, Suzuki M

  Journal of neuro-oncology 168 ( 1 ) 91 - 97 2024.04

  Joint Work,  ISSN  0167-594X

  • Access to Document (DOI)

• A comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study.

  Kurokawa S, Nomura K, Sanada K, Miyaho K, Ishii C, Fukuda S, Iwamoto C, Naraoka M, Yoneda S, Imafuku M, Matsuzaki J, Saito Y, Mimura M, Kishimoto T

  Journal of child psychology and psychiatry, and allied disciplines 65 ( 9 ) 1184 - 1195 2024.04

  Joint Work,  ISSN  0021-9630

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Functional analysis of extracellular miRNAs as indicators of liver fibrosis

  Matsuzaki, Juntaro

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2022

• Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma

  Matsuzaki, Juntaro

  科学研究費補助金研究成果報告書 2015

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 細胞外小胞に含まれるタンパク質COPB2の呼吸器疾患バイオマーカーとしての有用性の検討

  檀 裕治, 松崎 潤太郎, 藤田 雄, 朝倉 啓介, 大村 征司, 山口 智子, 落合 孝広, 齋藤 義正

  日本分子腫瘍マーカー研究会プログラム・講演抄録 (日本分子腫瘍マーカー研究会)  44回   40 - 40 2024.09

• 肝臓がん患者における血中循環"細菌由来RNA"プロファイルの特徴

  大嶋 一輝, 松崎 潤太郎, 中山 淳, 津川 仁, 山本 雄介, 加藤 健, 落合 孝広, 齋藤 義正

  日本分子腫瘍マーカー研究会プログラム・講演抄録 (日本分子腫瘍マーカー研究会)  44回   56 - 56 2024.09

• ガイドラインの検証　Helicobacter pylori感染の診断と治療のガイドライン改訂版　診断

  豊島 治, 松崎 潤太郎, 太田 浩良, 大崎 敬子, 下山 克

  日本ヘリコバクター学会学術集会プログラム・抄録集 ((一社)日本ヘリコバクター学会)  30回   98 - 98 2024.06

• ピロリ治療の諸問題　ペニシリンアレルギーH.pylori感染症例に対する10day VMSの有用性

  安藤 裕子, 森 英毅, 舟山 武鴻, 松崎 潤太郎, 猪口 和美, 岡沢 啓, 吉岡 政洋, 齋藤 義正, 鈴木 秀和, 金井 隆典, 正岡 建洋

  日本ヘリコバクター学会学術集会プログラム・抄録集 ((一社)日本ヘリコバクター学会)  30回   91 - 91 2024.06

• 細胞外小胞研究最前線　Klebsiella pneumoniaeの菌体外膜小胞による生体ハイジャックが誘導する細菌転移

  津川 仁, 椿 翔吾, 田中 里佳, 津々木 博康, 澤 智裕, 松崎 潤太郎

  日本細菌学雑誌 (日本細菌学会)  79 ( 2 ) 52 - 52 2024.06

  ISSN  0021-4930

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Checklist for blood sample collection when developing clinical application of blood EV biomarkers

  Matsuzaki J

  ISEV Workshop:Blood EVs 2024, 

  2024.09

  , 

  Oral presentation (invited, special)

• Frontiers of Next-Generation Cancer Testing Technology Using microRNAs

  Matsuzaki J

  第83回日本癌学会学術総会, 

  2024.09

  , 

  Symposium, workshop panel (nominated)

• 細胞外小胞研究と毒素研究のアナロジーを探る

  松崎潤太郎

  第70回トキシンシンポジウム, 

  2024.08

  , 

  Oral presentation (invited, special)

• 細胞外小胞で産学連携で社会実装

  松崎潤太郎

  日本薬学会 第144年会, 

  2024.03

  , 

  Symposium, workshop panel (nominated)

• 細菌が放出する細胞外RNAの解析

  松崎潤太郎

  第8回リキッドバイオプシー研究会, 

  2024.02

  , 

  Symposium, workshop panel (nominated)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Comprehensive elucidation of the mechanisms of circulating microRNA variability during pancreatic carcinogenesis

  2022.04

  -

  2025.03

  Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

  　View Summary

  膵がんのように早期診断技術開発が待望される腫瘍において、血中マイクロRNA (miRNA)診断の実用化が期待されている。多くの臨床検体の解析から、そのコンセプトの正しさは実証されているが、血中miRNAによってなぜ膵がんが診断できるのか証明しきれていない。特に膵腫瘍の発生によって周辺の細胞や免疫細胞などが反応し、分泌するmiRNAが変化することも、血中miRNAに大きく影響している可能性がある。本研究はこれらの点を考慮し、マウスで膵発がん過程での血中miRNA変化を追跡し、その生理学的意義を明らかにすることで、実臨床における血中miRNA診断実用化に必須となる基盤的知見を提供する。

• CRISPR-Cas9 based screening for essential tumor suppressors in liver carcinogenesis

  2017.06

  -

  2020.03

  National Cancer Center Japan, Yamamoto Yusuke, Grant-in-Aid for Challenging Research (Exploratory), No Setting

  　View Summary

  A large number of research projects identified genetic mutations in the process of carcinogenesis, and there have been some useful findings of studies using cancer cell lines. With next generation sequencing, genetic variants in a variety of cancers have been identified and shown to have an impact on carcinogenesis; however, it is still unclear how the mutations essentially influenced the carcinogenesis and their metastatic potential. In this research project, we introduced and quantitatively analyzed the contribution of genetic mutations involved in the carcinogenic process by CRISPR-Cas9, in order to knockout the tumor suppressor genes in primary epithelial cells, and examined the effect of each gene on carcinogenesis. Also, we tried to recapitulate the multi-step carcinogenesis in vitro. This study enables us to accurately reflect and reproduce genomic aberrations in normal cells, and to achieve validation of the actual function of driver gene mutations.

• Identification of circulating microRNAs for the detection of early stage pancreatic cancer

  2017.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Matsuzaki Juntaro, Grant-in-Aid for Scientific Research (C), Principal investigator

  　View Summary

  We established the culturing method of pancreatic progenitor cells by chemical direct reprogramming of pancreatic exocrine cells isolated from mouse pancreas. We then investigated the alteration in intracellular and extracellular miRNAs during the exposure to bile acid, which is a potential cause of pancreatic carcinogenesis. As a result, several miRNAs including miR-296-5p and miR-135a-3p were identified as miRNAs whose secretion into the cell culture supernatant was enhanced. These miRNAs are expected to be biomarkers for the early-stage pancreatic cancer.

• Generation of hepatic progenitor cells from human hepatocytes using small molecules

  2016.04

  -

  2018.03

  National Cancer Center Japan, KATSUDA Takeshi, OCHIYA Takahiro, MATSUZAKI Juntaro, SAITO Yoshimasa, TAKEUCHI Atsuko, Grant-in-Aid for Young Scientists (B), No Setting

  　View Summary

  Using small molecule inhibitors, we recently reported that rodent mature hepatocytes can be reprogrammed into progenitor-like phenotype with repopulative capacity. In this study, using the same strategy, we demonstrated that hepatic progenitor cells can be induced from human infant hepatocytes. These cells, named human chemically induced progenitors (hCLiPs), exhibited significant repopulative capacity in injured mouse livers following transplantation, and contributed to reconstruction of the normal liver architecture. We also found that hCLiPs can be redifferentiated into mature hepatocytes in vitro with hepatic inducible factors. These redifferentiated cells can be induced to exhibit cytochrome P450 (CYP) enzymatic activities in response to the CYP inducing molecules with the efficiency comparable with that of primary hepatocytes. Thus, this study contributes to progress in the field of liver cell transplantation therapy and pharmacological research field.

• Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma

  2014.04

  -

  2016.03

  Keio University, Matsuzaki Juntaro, TSUGAWA Hitoshi, SUZUKI Hidekazu, Grant-in-Aid for Young Scientists (B), No Setting

  　View Summary

  Esophageal adenocarcinoma, which is rapidly increasing in Western countries, is one of the complications of gastroesophageal reflux disease. Bile reflux and central obesity are major risk factors for esophageal adenocarcinoma. In general, plasma adiponectin levels are decreased through the progression of central obesity. We had reported that bile acids contribute to carcinogenesis through the activation of nuclear bile acid receptor (FXR) and the enhancement of miR-221/222. Herein, we identified that miR-221/222 enhance the expression of COX-2 in esophageal epithelial cells. On the other hand, COX-2 expression was suppressed during exposure to adiponectin receptor agonist. These results suggest adiponectin receptor agonist might work as a chemopreventive agent for esophageal adenocarcinoma among high-risk individuals with central obesity.

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• 慶應義塾大学薬学部長賞

  2024.04

  Type of Award： Keio commendation etc.

• 日本癌学会奨励賞

  2020

  Type of Award： Award from Japanese society, conference, symposium, etc.

• the 15th Korea-Japan Joint Symposium on Helicobacter infection Young Investigator Award

  2018

  Type of Award： Award from international society, conference, symposium, etc.

• United European Gastroenterology Week (UEGW) 2016 Poster of Excellence

  2016

  Type of Award： Award from international society, conference, symposium, etc.

• 第18回日本神経消化器病学会・第6回IBS研究会・第84回消化器心身医学研究会・第10回機能性ディスペプシア研究会合同学術集会 並木賞

  2016

  Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• THAI PHARMACY EXPERIENCE

  2024

• STUDY OF MAJOR FIELD: (PHARMACOTHERAPEUTICS)

  2024

• SEMINAR:(PHARMACOTHERAPEUTICS)

  2024

• RESEARCH FOR BACHELOR'S THESIS 1

  2024

• PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

  2024

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本内科学会, 

  2005

  -

  Present

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2024.04

  -

  Present

  日本細胞外小胞学会　理事

• 2024.01

  -

  Present

  日本消化器病学会　関東支部　評議員

• 2023.01

  -

  Present

  日本癌学会　評議員

• 2019

  -

  Present

  日本微小循環学会　評議員

• 2018

  -

  Present

  日本ヘリコバクター学会　代議員