MATSUZAKI Juntaro

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy Division of Pharmacotherapeutics (Shiba-Kyoritsu)

Position

Associate Professor

Related Websites

External Links
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Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, Coursework, 2013

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Research Areas 【 Display / hide 】

  • Life Science / Tumor diagnostics and therapeutics

  • Life Science / Gastroenterology

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Research Keywords 【 Display / hide 】

  • cancer

  • microRNA

  • extracellular RNA

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Books 【 Display / hide 】

  • テクノロジーロードマップ2023-2032 医療・健康・食農編

    松﨑潤太郎, 落谷孝広, 日経BP, 2023.03

    Scope: 多がん早期検出

  • 疾患バイオマーカーとしてのマイクロRNAと診断応用

    松﨑潤太郎, 落谷孝広, シーエムシー出版, 2022.06

  • 消化器系疾患(2). Principal Pharmacotherapy (改訂3版)

    松﨑潤太郎, ネオメディカル, 2022.04

  • 胃・十二指腸潰瘍. 看護基礎教育テキスト ナーシング・グラフィカ「疾患と看護シリーズ」『3 消化器疾患と看護』

    松﨑潤太郎, 鈴木秀和, メディカ出版, 2019.12

  • テクノロジーロードマップ2019-2028 医療・健康・食農編

    松﨑潤太郎, 落谷孝広, 日経BP, 2019.03

    Scope: がん早期診断

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Papers 【 Display / hide 】

  • Upper gastrointestinal triple stenosis in a patient with trisomy 17p syndrome: Case report and literature review.

    Ando H, Mori H, Takabayashi K, Matsuura N, Masaoka T, Matsuzaki J, Saito Y, Kato M, Kosaki K, Kanai T

    DEN open 5 ( 1 ) e70043 2025.04

    Research paper (scientific journal), Joint Work, Accepted

  • Circulating serum miRNAs predict response to platinum chemotherapy in high-grade serous ovarian cancer.

    Suzuki K, Yokoi A, Matsuzaki J, Yoshida K, Yamamoto Y, Kato T, Ishikawa M, Ochiya T, Kajiyama H

    Cancer medicine 13 ( 22 ) e70251 2024.11

    Research paper (scientific journal), Joint Work, Accepted

  • Macrophage-depleted young mice are beneficial in vivo models to assess the translocation of Klebsiella pneumonia from the gastrointestinal tract to the liver in the elderly.

    Tsugawa H, Tsubaki S, Tanaka R, Nashimoto S, Imai J, Matsuzaki J, Hozumi K

    Microbes and infection 26 ( 8 ) 105371 2024.06

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1286-4579

  • Potential utility of pretreatment serum miRNAs for optimal treatment selection in advanced high-grade serous ovarian cancer.

    Uehara T, Matsuzaki J, Yoshida H, Ogawa Y, Miura J, Fujimiya H, Yamamoto Y, Kawauchi J, Takizawa S, Yonemori K, Sakamoto H, Kato K, Ishikawa M, Ochiya T

    Japanese journal of clinical oncology 54 ( 8 ) 917 - 925 2024.04

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0368-2811

  • Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy.

    Kondo N, Kinouchi T, Natsumeda M, Matsuzaki J, Hirata E, Sakurai Y, Okada M, Suzuki M

    Journal of neuro-oncology 168 ( 1 ) 91 - 97 2024.04

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0167-594X

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 【細胞外小胞・エクソソームの医療応用の未来】疾患における細胞外小胞研究　膵臓がんにおける細胞外小胞

    関戸 愛香, 松崎 潤太郎, 齋藤 義正

    医学のあゆみ (医歯薬出版(株))  291 ( 9 ) 711 - 716 2024.11

    ISSN  0039-2359

    　View Summary

    ＜文献概要＞膵臓がん(PDAC)は,自覚症状が少なく画像診断のみでは早期発見が難しい.PDACを含む多くのがんにおいて初期段階の発見により,外科的治療を施すことが可能となる.そのため,早期発見に役立つバイオマーカーの発見が治癒の可能性を高める方法となる.現在使用されている血中バイオマーカーである血清糖鎖抗原19-9(CA19-9)やがん胎児性抗原(CEA)では,早期のPDAC診断性能が十分ではない.そこで,PDACおよびその前がん病変である膵上皮内腫瘍(PanIN),管内乳頭状粘液性腫瘍(IPMN),粘液性嚢胞性腫瘍(MCN)に注目し,細胞外小胞(EV)が輸送するmiRNAやタンパク質のなかで,これらの病変の早期発見のカギとなる新たなバイオマーカーについて紹介する.

  • FD・IBS・慢性便秘症の最前線　機能性ディスペプシア評価法としての低用量流動食負荷試験および自律神経機能検査の有用性

    森 英毅, 正岡 建洋, 松崎 潤太郎, 佐藤 萌, 安藤 裕子, 金井 隆典

    日本臨床生理学会雑誌 (日本臨床生理学会)  54 ( 4 ) 77 - 77 2024.10

    ISSN  0286-7052

  • miRNomes解析による筋層浸潤性膀胱癌における術後腫瘍学転帰予測モデルの検討

    占部 文彦, 松崎 潤太郎, 伊藤 景紀, 高森 一, 都筑 俊介, 三木 淳, 木村 高弘, 中村 英二郎, 藤元 博行, 山本 雄介, 落谷 孝広, 松井 喜之

    日本癌治療学会学術集会抄録集 ((一社)日本癌治療学会)  62回   O32 - 1 2024.10

  • 肝臓がん患者における血中循環"細菌由来RNA"プロファイルの特徴

    大嶋 一輝, 松崎 潤太郎, 中山 淳, 津川 仁, 山本 雄介, 加藤 健, 落合 孝広, 齋藤 義正

    日本分子腫瘍マーカー研究会プログラム・講演抄録 (日本分子腫瘍マーカー研究会)  44回   56 - 56 2024.09

  • 細胞外小胞に含まれるタンパク質COPB2の呼吸器疾患バイオマーカーとしての有用性の検討

    檀 裕治, 松崎 潤太郎, 藤田 雄, 朝倉 啓介, 大村 征司, 山口 智子, 落合 孝広, 齋藤 義正

    日本分子腫瘍マーカー研究会プログラム・講演抄録 (日本分子腫瘍マーカー研究会)  44回   40 - 40 2024.09

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Presentations 【 Display / hide 】

  • 機能性消化管障害診療の最適化への取り組み

    松崎潤太郎

    日本消化器病学会関東支部 第45回教育講演会, 

    2024.11
    , 

    Public lecture, seminar, tutorial, course, or other speech

  • 生物界を飛びこえる細胞外RNA

    松崎潤太郎

    第4回反分野的生物医療学会学術集会, 

    2024.09
    , 

    Oral presentation (general)

  • Checklist for blood sample collection when developing clinical application of blood EV biomarkers

    Matsuzaki J

    ISEV Workshop:Blood EVs 2024, 

    2024.09
    , 

    Oral presentation (invited, special)

  • Frontiers of Next-Generation Cancer Testing Technology Using microRNAs

    Matsuzaki J

    第83回日本癌学会学術総会, 

    2024.09
    , 

    Symposium, workshop panel (nominated)

  • 細胞外小胞研究と毒素研究のアナロジーを探る

    松崎潤太郎

    第70回トキシンシンポジウム, 

    2024.08
    , 

    Oral presentation (invited, special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Comprehensive elucidation of the mechanisms of circulating microRNA variability during pancreatic carcinogenesis

    2022.04
    -
    2025.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

    　View Summary

    膵がんのように早期診断技術開発が待望される腫瘍において、血中マイクロRNA (miRNA)診断の実用化が期待されている。多くの臨床検体の解析から、そのコンセプトの正しさは実証されているが、血中miRNAによってなぜ膵がんが診断できるのか証明しきれていない。特に膵腫瘍の発生によって周辺の細胞や免疫細胞などが反応し、分泌するmiRNAが変化することも、血中miRNAに大きく影響している可能性がある。本研究はこれらの点を考慮し、マウスで膵発がん過程での血中miRNA変化を追跡し、その生理学的意義を明らかにすることで、実臨床における血中miRNA診断実用化に必須となる基盤的知見を提供する。

  • CRISPR-Cas9 based screening for essential tumor suppressors in liver carcinogenesis

    2017.06
    -
    2020.03

    National Cancer Center Japan, Yamamoto Yusuke, Grant-in-Aid for Challenging Research (Exploratory), No Setting

    　View Summary

    A large number of research projects identified genetic mutations in the process of carcinogenesis, and there have been some useful findings of studies using cancer cell lines. With next generation sequencing, genetic variants in a variety of cancers have been identified and shown to have an impact on carcinogenesis; however, it is still unclear how the mutations essentially influenced the carcinogenesis and their metastatic potential. In this research project, we introduced and quantitatively analyzed the contribution of genetic mutations involved in the carcinogenic process by CRISPR-Cas9, in order to knockout the tumor suppressor genes in primary epithelial cells, and examined the effect of each gene on carcinogenesis. Also, we tried to recapitulate the multi-step carcinogenesis in vitro. This study enables us to accurately reflect and reproduce genomic aberrations in normal cells, and to achieve validation of the actual function of driver gene mutations.

  • Identification of circulating microRNAs for the detection of early stage pancreatic cancer

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Matsuzaki Juntaro, Grant-in-Aid for Scientific Research (C), Principal investigator

    　View Summary

    We established the culturing method of pancreatic progenitor cells by chemical direct reprogramming of pancreatic exocrine cells isolated from mouse pancreas. We then investigated the alteration in intracellular and extracellular miRNAs during the exposure to bile acid, which is a potential cause of pancreatic carcinogenesis. As a result, several miRNAs including miR-296-5p and miR-135a-3p were identified as miRNAs whose secretion into the cell culture supernatant was enhanced. These miRNAs are expected to be biomarkers for the early-stage pancreatic cancer.

  • Generation of hepatic progenitor cells from human hepatocytes using small molecules

    2016.04
    -
    2018.03

    National Cancer Center Japan, KATSUDA Takeshi, OCHIYA Takahiro, MATSUZAKI Juntaro, SAITO Yoshimasa, TAKEUCHI Atsuko, Grant-in-Aid for Young Scientists (B), No Setting

    　View Summary

    Using small molecule inhibitors, we recently reported that rodent mature hepatocytes can be reprogrammed into progenitor-like phenotype with repopulative capacity. In this study, using the same strategy, we demonstrated that hepatic progenitor cells can be induced from human infant hepatocytes. These cells, named human chemically induced progenitors (hCLiPs), exhibited significant repopulative capacity in injured mouse livers following transplantation, and contributed to reconstruction of the normal liver architecture. We also found that hCLiPs can be redifferentiated into mature hepatocytes in vitro with hepatic inducible factors. These redifferentiated cells can be induced to exhibit cytochrome P450 (CYP) enzymatic activities in response to the CYP inducing molecules with the efficiency comparable with that of primary hepatocytes. Thus, this study contributes to progress in the field of liver cell transplantation therapy and pharmacological research field.

  • Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma

    2014.04
    -
    2016.03

    Keio University, Matsuzaki Juntaro, TSUGAWA Hitoshi, SUZUKI Hidekazu, Grant-in-Aid for Young Scientists (B), No Setting

    　View Summary

    Esophageal adenocarcinoma, which is rapidly increasing in Western countries, is one of the complications of gastroesophageal reflux disease. Bile reflux and central obesity are major risk factors for esophageal adenocarcinoma. In general, plasma adiponectin levels are decreased through the progression of central obesity. We had reported that bile acids contribute to carcinogenesis through the activation of nuclear bile acid receptor (FXR) and the enhancement of miR-221/222. Herein, we identified that miR-221/222 enhance the expression of COX-2 in esophageal epithelial cells. On the other hand, COX-2 expression was suppressed during exposure to adiponectin receptor agonist. These results suggest adiponectin receptor agonist might work as a chemopreventive agent for esophageal adenocarcinoma among high-risk individuals with central obesity.

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Awards 【 Display / hide 】

  • 慶應義塾大学薬学部長賞

    2024.04

    Type of Award： Keio commendation etc.

  • 日本癌学会奨励賞

    2020

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • the 15th Korea-Japan Joint Symposium on Helicobacter infection Young Investigator Award

    2018

    Type of Award： Award from international society, conference, symposium, etc.

  • United European Gastroenterology Week (UEGW) 2016 Poster of Excellence

    2016

    Type of Award： Award from international society, conference, symposium, etc.

  • 第18回日本神経消化器病学会・第6回IBS研究会・第84回消化器心身医学研究会・第10回機能性ディスペプシア研究会合同学術集会 並木賞

    2016

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • ENGLISH EXERCISES FOR PHARMACEUTICAL SCIENCES

    2024

  • EARLY EXPOSURE TO INDUSTRY

    2024

  • DISEASES AND PHARMACOTHERAPY 3 (PSYCHIATRIC DISEASES AND OTHERS)

    2024

  • CLINICAL PHARMACOLOGY

    2024

  • BACHELOR'S THESIS

    2024

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Memberships in Academic Societies 【 Display / hide 】

  • 日本内科学会, 

    2005
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2024.04
    -
    Present

    日本細胞外小胞学会　理事

  • 2024.01
    -
    Present

    日本消化器病学会　関東支部　評議員

  • 2023.01
    -
    Present

    日本癌学会　評議員

  • 2019
    -
    Present

    日本微小循環学会　評議員

  • 2018
    -
    Present

    日本ヘリコバクター学会　代議員

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