研究者詳細 - 山元　良

論文 - 山元　良

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Risk factors for peripheral intravascular catheter-related phlebitis in critically ill patients: analysis of 3429 catheters from 23 Japanese intensive care units.

Yasuda H, Rickard CM, Marsh N, Yamamoto R, Kotani Y, Kishihara Y, Kondo N, Sekine K, Shime N, Morikane K, Abe T, AMOR-NUS study group

Annals of intensive care 12 （ 1 ） 33 - 33 2022年04月

ISSN 2110-5820

BACKGROUND: Phlebitis is an important complication occurring in patients with peripheral intravascular catheters (PIVCs). The risk factors for phlebitis in the intensive care unit (ICU) was examined. METHODS: A secondary analysis of a prospective multicenter cohort study was conducted, involving 23 ICUs in Japan-the AMOR-VENUS study. Consecutive patients aged ≥ 18 years admitted to the ICU with newly inserted PIVCs after ICU admission were enrolled. Characteristics of the ICU, patients, PIVCs, and the drugs administered via PIVCs were recorded. A marginal Cox regression model was used to identify the risk factors associated with phlebitis. RESULTS: A total of 2741 consecutive patients from 23 ICUs were reviewed for eligibility, resulting in 1359 patients and 3429 PIVCs being included in the analysis population. The median dwell time was 46.2 h (95% confidence interval [CI], 21.3-82.9). Phlebitis occurred in 9.1% (95% CI, 8.2-10.1%) of catheters (3.5 cases/100 catheter days). The multivariate analysis revealed that the only factors that increased the risk of developing phlebitis were drugs administered intravenously. This study included 26 drugs, and 4 were associated with increased phlebitis: nicardipine (HR, 1.85; 95% CI, 1.29-2.66), noradrenaline (HR, 2.42; 95% CI, 1.40-4.20), amiodarone (HR, 3.67; 95% CI, 1.75-7.71) and levetiracetam (HR, 5.65; 95% CI, 2.80-11.4). Alternatively, factors significantly associated with a reduced risk of phlebitis were: standardized drug administration measures in the ICU (HR, 0.35; 95% CI, 0.17-0.76), 30≤ BMI (HR, 0.43; 95% CI, 0.20-0.95), catheter inserted by a doctor as nurse reference (HR, 0.55; 95% CI, 0.32-0.94), and upper arm insertion site as forearm reference (HR, 0.52; 95% CI, 0.32-0.85). The nitroglycerin was associated with a reduced phlebitis risk (HR, 0.22; 95% CI, 0.05-0.92). CONCLUSION: Various factors are involved in the development of phlebitis caused by PIVCs in critically ill patients, including institutional, patient, catheter, and drug-induced factors, indicating the need for appropriate device selection or models of care in the ICU. TRIAL REGISTRATION: UMIN-CTR, the Japanese clinical trial registry (registration number: UMIN000028019, July 1, 2017).

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Nasal intubation for trauma patients and increased in-hospital mortality.

Yamamoto R, Fujishima S, Sasaki J

European journal of trauma and emergency surgery : official publication of the European Trauma Society （European Journal of Trauma and Emergency Surgery） 48 （ 4 ） 2795 - 2802 2022年01月

ISSN 1863-9933

Purpose: Data regarding harm from nasal intubation in trauma patients have been conflicting. This study aims to elucidate whether nasal intubation is associated with increased in-hospital mortality compared with oral intubation. Methods: A retrospective cohort study on a nationwide trauma registry of 2004–2019 was conducted. Adult trauma patients who underwent nasal or oral intubation during initial resuscitation were selected. In-hospital mortality and lung complications were compared between nasal and oral intubations. A generalized estimating equation model accounting for within-institution clustering was adopted. Patient demographics, comorbidities, mechanism, injury severity, and vital signs on hospital arrival were adjusted. Subgroup analyses were conducted based on age, Abbreviated Injury Scale [AIS] for the head and face, and vital signs on arrival. Results: Among 29,271 patients eligible for the study, 667 were intubated nasally. In-hospital mortality was higher in nasal intubation compared with oral intubation (OR, 1.28 [95% CI, 1.01–1.64]). There were more noninfectious pulmonary complications in nasal intubation (OR, 1.48 [1.14–1.94]). The harms of nasal intubation were observed only in the elderly (age ≥ 75), patients with severe head injury (AIS in the head ≥ 4), and normotensive patients (systolic blood pressure ≥ 90 mmHg). Conversely, mortality was comparable regardless of the route of intubation in patients with complicated facial injury (AIS in the face ≥ 3). Conclusion: Nasal intubation was associated with increased in-hospital mortality, particularly in older patients and severe head injury, but not severe facial injury. The route of intubation should be judiciously decided during trauma resuscitation.

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Japanese rapid/living recommendations on drug management for COVID-19: updated guidelines (July 2022).

Yamakawa K, Yamamoto R, Terayama T, Hashimoto H, Ishihara T, Ishimaru G, Imura H, Okano H, Narita C, Mayumi T, Yasuda H, Yamada K, Yamada H, Kawasaki T, Shime N, Doi K, Egi M, Ogura H, Aihara M, Kushimoto S, Nishida O, Special Committee of the Japanese Clinical Practice Guidelines for the Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020), the COVID‐19 Task Force

Acute medicine & surgery 9 （ 1 ） e789 2022年01月

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Development of On-Site Medical System for Mass-Gathering Events During TOKYO 2020: Vulnerability Analysis Using Healthcare Failure Mode and Effect Analysis.

Yamamoto R, Maeshima K, Asakawa S, Haiden A, Nishida Y, Yamazaki N, Homma K, Sasaki J

Disaster medicine and public health preparedness （Disaster Medicine and Public Health Preparedness） 17 （ 4 ） 1 - 7 2021年12月

共著, ISSN 1935-7893

At mass-gathering events of the Olympic and Paralympic Games, a well-organized, on-site medical system is essential. This study evaluated the vulnerabilities of the prehospital medical system of the TOKYO 2020 Olympic and Paralympic Games (TOKYO2020) to propose corrections that can be generalized to other mass gatherings. The healthcare failure mode and effect analysis (HFMEA) was adopted to analyze vulnerabilities of the on-site medical system proposed by the organizing committee of TOKYO2020. Processes from detecting a patient on the scene to completing transport to a hospital were analyzed. Ten processes with 47 sub-processes and 122 possible failure modes were identified. HFMEA revealed 9 failure modes as vulnerabilities: misidentification of patient, delayed immediate care at the scene, misjudgment of disposition from the on-site medical suite, and inappropriate care during transportation to hospital. Proposed corrections included surveillance to decrease blind spots, first aid brochures for spectators, and uniform protocol for health care providers at the scene. The on-site medical system amended by HFMEA seemed to work appropriately in TOKYO2020.

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Serum D-dimer level as a biomarker for identifying patients with isolated injury to prevent unnecessary whole-body computed tomography in blunt trauma care

Nakama R., Yamamoto R., Izawa Y., Tanimura K., Mato T.

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine （Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine） 29 （ 1 ） 12 - 12 2021年12月

研究論文（学術雑誌）, 共著

Background: Unnecessary whole-body computed tomography (CT) may lead to excess radiation exposure. Serum D-dimer levels have been reported to correlate with injury severity. We examined the predictive value of serum D-dimer level for identifying patients with isolated injury that can be diagnosed with selected-region CT rather than whole-body CT. Methods: This single-center retrospective cohort study included patients with blunt trauma (2014–2017). We included patients whose serum D-dimer levels were measured before they underwent whole-body CT. “Isolated” injury was defined as injury with Abbreviated Injury Scale (AIS) score ≤ 5 to any of five regions of interest or with AIS score ≤ 1 to other regions, as revealed by a CT scan. A receiver operating characteristic curve (ROC) was drawn for D-dimer levels corresponding to isolated injury; the area under the ROC (AUROC) was evaluated. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for several candidate cut-off values for serum D-dimer levels. Results: Isolated injury was detected in 212 patients. AUROC was 0.861 (95% confidence interval [CI]: 0.815–0.907) for isolated injury prediction. Serum D-dimer level ≤ 2.5 μg/mL was an optimal cutoff value for predicting isolated injury with high specificity (100.0%) and positive predictive value (100.0%). Approximately 30% of patients had serum D-dimer levels below this cutoff value. Conclusion: D-dimer level ≤ 2.5 μg/mL had high specificity and high positive predictive value in cases of isolated injury, which could be diagnosed with selected-region CT, reducing exposure to radiation associated with whole-body CT.

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Hyperoxemia during resuscitation of trauma patients and increased intensive care unit length of stay: inverse probability of treatment weighting analysis

Yamamoto R., Fujishima S., Sasaki J., Gando S., Saitoh D., Shiraishi A., Kushimoto S., Ogura H., Abe T., Mayumi T., Kotani J., Nakada T.a., Shiino Y., Tarui T., Okamoto K., Sakamoto Y., Shiraishi S.I., Takuma K., Tsuruta R., Masuno T., Takeyama N., Yamashita N., Ikeda H., Ueyama M., Hifumi T., Yamakawa K., Hagiwara A., Otomo Y.

World Journal of Emergency Surgery （World Journal of Emergency Surgery） 16 （ 1 ） 19 - 19 2021年12月

研究論文（学術雑誌）, 共著

Background: Information on hyperoxemia among patients with trauma has been limited, other than traumatic brain injuries. This study aimed to elucidate whether hyperoxemia during resuscitation of patients with trauma was associated with unfavorable outcomes. Methods: A post hoc analysis of a prospective observational study was carried out at 39 tertiary hospitals in 2016–2018 in adult patients with trauma and injury severity score (ISS) of > 15. Hyperoxemia during resuscitation was defined as PaO2 of ≥ 300 mmHg on hospital arrival and/or 3 h after arrival. Intensive care unit (ICU)-free days were compared between patients with and without hyperoxemia. An inverse probability of treatment weighting (IPW) analysis was conducted to adjust patient characteristics including age, injury mechanism, comorbidities, vital signs on presentation, chest injury severity, and ISS. Analyses were stratified with intubation status at the emergency department (ED). The association between biomarkers and ICU length of stay were then analyzed with multivariate models. Results: Among 295 severely injured trauma patients registered, 240 were eligible for analysis. Patients in the hyperoxemia group (n = 58) had shorter ICU-free days than those in the non-hyperoxemia group [17 (10–21) vs 23 (16–26), p < 0.001]. IPW analysis revealed the association between hyperoxemia and prolonged ICU stay among patients not intubated at the ED [ICU-free days = 16 (12–22) vs 23 (19–26), p = 0.004], but not among those intubated at the ED [18 (9–20) vs 15 (8–23), p = 0.777]. In the hyperoxemia group, high inflammatory markers such as soluble RAGE and HMGB-1, as well as low lung-protective proteins such as surfactant protein D and Clara cell secretory protein, were associated with prolonged ICU stay. Conclusions: Hyperoxemia until 3 h after hospital arrival was associated with prolonged ICU stay among severely injured trauma patients not intubated at the ED. Trial registration: UMIN-CTR, UMIN000019588. Registered on November 15, 2015.

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Emergency angiography for trauma patients and potential association with acute kidney injury

Yamamoto R., Cestero R.F., Yoshizawa J., Maeshima K., Sasaki J.

World Journal of Emergency Surgery （World Journal of Emergency Surgery） 16 （ 1 ） 56 2021年12月

共著

Background: Angiography has been conducted as a hemostatic procedure for trauma patients. While several complications, such as tissue necrosis after embolization, have been reported, little is known regarding subsequent acute kidney injury (AKI) due to contrast media. To elucidate whether emergency angiography would introduce kidney dysfunction in trauma victims, we compared the incidence of AKI between patients who underwent emergency angiography and those who did not. Methods: A retrospective cohort study was conducted using a nationwide trauma database (2004–2019), and adult trauma patients were included. The indication of emergency angiography was determined by both trauma surgeons and radiologists, and AKI was diagnosed by treating physicians based on a rise in serum creatinine and/or fall in urine output according to any published standard criteria. Incidence of AKI was compared between patients who underwent emergency angiography and those who did not. Propensity score matching was conducted to adjust baseline characteristics including age, comorbidities, mechanism of injury, vital signs on admission, Injury Severity Scale (ISS), degree of traumatic kidney injury, surgical procedures, and surgery on the kidney, such as nephrectomy and nephrorrhaphy. Results: Among 230,776 patients eligible for the study, 14,180 underwent emergency angiography. The abdomen/pelvis was major site for angiography (10,624 [83.5%]). Embolization was performed in 5,541 (43.5%). Propensity score matching selected 12,724 pairs of severely injured patients (median age, 59; median ISS, 25). While the incidence of AKI was rare, it was higher among patients who underwent emergency angiography than in those who did not (140 [1.1%] vs. 67 [0.5%]; odds ratio = 2.10 [1.57–2.82]; p < 0.01). The association between emergency angiography and subsequent AKI was observed regardless of vasopressor usage or injury severity in subgroup analyses. Conclusions: Emergency angiography in trauma patients was probably associated with increased incidence of AKI. The results should be validated in future studies.

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集中治療にて救命しえた腎移植後COVID-19の1例

森田伸也, 高橋遼平, 浅岡雅人, 山元良, 長田大雅, 本間康一郎, 川田一郎, 吉田理, 石井誠, 浅沼宏, 中川健, 大家基嗣

日本臨床腎移植学会雑誌（(一社)日本臨床腎移植学会） 9 （ 2 ） 207 - 210 2021年12月

ISSN 2187-9907

56歳男性。紫斑病性腎炎による慢性腎不全にてX-19年血液透析導入、同年血液型適合生体腎移植施行。維持免疫抑制剤はシクロスポリン(CyA)、ミコフェノール酸モフェチル(MMF)、プレドニゾロン(PSL)であった。X年に頭重感と微熱を主訴に来院、CTにて肺一部にすりガラス影を認め、鼻咽頭PCRにてSARS-CoV-2陽性となり緊急入院。MMF減量しファビピラビル、セフトリアキソン投与開始した。さらに抗生剤をタゾバクタム/ピペラシリンに、PSLをデキサメタゾンとしMMFを中止した。肺炎増悪したためメチルプレドニゾロン(mPSL)90mg/day投与、抗凝固療法開始しCyA減量した。呼吸状態増悪のため人工呼吸器管理としCyA中止、レムデシビル投与開始、腹臥位療法を施行した。一時血液透析を3回施行。徐々に酸素化は改善しmPSLは漸減とした。細菌性肺炎合併を疑い抗生剤をバンコマイシンとメロペネムとし、肺炎は改善した。下気道PCRにてSARS-CoV-2陰性を2回確認後CyA、MMFを再開し退院となった。(著者抄録)

複合的指標に基づく重症外傷患者選別基準とアンダートリアージの低下

矢島慶太郎, 山元良, 船曳知弘, 北野光秀, 佐々木淳一

日本救急医学会雑誌（(一社)日本救急医学会） 32 （ 11 ） 551 - 558 2021年11月

共著, ISSN 0915-924X

【目的】重症外傷の病院前選別ではアンダートリアージの減少が予後改善に寄与するとされているが,本邦では病院前の重症外傷選定基準に関する研究は少ない。そこで,受傷機転と生理学的・解剖学的所見による複合的基準が重症外傷のアンダートリアージ減少に関連しているか検証した。【対象】2016年10月からの2年間に横浜市指定4区で発生した外傷患者を対象に,後ろ向き観察研究を行った。現場から搬送され入院あるいは外来死亡した症例の中で,来院時心肺停止を除外し解析を行った。研究期間前半はショックを伴う頸胸腹損傷・両側大腿骨骨折を重症外傷と判定し(基準A),後半は高リスク受傷機転および生理学的・解剖学的異常所見を複合的に用いて判定した(基準B)。基準を満たさず搬送され重症外傷と診断された症例をアンダートリアージとし,各基準のアンダートリアージ率を比較した。【結果】539例の対象症例のうち,基準A運用期間は281例,基準B運用期間は258例であった。年齢や重症度は両期間とも相似していたが,緊急手術は基準B運用期間で多かった。アンダートリアージ率は,基準Aで27.6%,基準Bで18.1%であり,基準Bで有意に低かった(p=0.04)。【結語】外傷患者の搬送プロトコールにおいて,受傷機転,生理学的所見,および解剖学的所見を複合的に用いた重症患者選別基準がアンダートリアージの減少につながることが示唆された。(著者抄録)

来院時低血圧と造影CT後の造影剤腎症

吉澤城, 山元良, 本間康一郎, 上倉英恵, 関根和彦, 小林陽介, 船曳知弘, 佐々木淳一

日本救急医学会雑誌（(一社)日本救急医学会） 32 （ 12 ） 1678 - 1678 2021年11月

ISSN 0915-924X

重症COVID-19における早期腹臥位療法の検討多施設共同後方視的研究

丸山修平, 山川一馬, 山元良, 遠藤彰, 田上隆, 金山周史, 齊藤福樹, 吉矢和久, 中森靖, 鍬方安行, J-RECOVER study group

日本救急医学会雑誌（(一社)日本救急医学会） 32 （ 12 ） 1485 - 1485 2021年11月

ISSN 0915-924X

Monitoring of gastric residual volume during enteral nutrition.

Yasuda H, Kondo N, Yamamoto R, Asami S, Abe T, Tsujimoto H, Tsujimoto Y, Kataoka Y

The Cochrane database of systematic reviews 9 （ 9 ） CD013335 2021年09月

ISSN 1361-6137

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Reply to Swinging the pendulum in prehospital trauma mortality needs a more holistic approach.

Yamamoto R, Suzuki M, Sasaki J

The journal of trauma and acute care surgery 91 （ 3 ） e81 - e82 2021年09月

共著, ISSN 2163-0755

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COVID-19ガイドラインにおける各薬剤の推奨 CQ1(ファビピラビル)、CQ2(レムデシビル)、CQ3(ハイドロキシクロロキン)、CQ4-1(ステロイド)、CQ4-2(ステロイドパルス)

寺山毅郎, 山川一馬, 橋本英樹, 井村春樹, 山元良, 石原唯史, 石丸剛, 岡野弘, 成田知大, 真弓卓也, 安田英人, 山田浩平, 山田博之, 川崎達也, 志馬伸朗, 土井研人, 江木盛時, 小倉裕司, 相原守夫, 田中裕, 西田修, 日本版敗血症診療ガイドライン2020特別委員会COVID-19対策タスクフォース

日本集中治療医学会雑誌（(一社)日本集中治療医学会） 28 （ Suppl.2 ） 295 - 295 2021年09月

ISSN 1340-7988

本邦初のMAGICappガイドライン MAGICppの活用方法について

山元良, 山川一馬, 橋本英樹, 寺山毅郎, 井村春樹, 石原唯史, 石丸剛, 岡野弘, 成田知大, 真弓卓也, 安田英人, 山田浩平, 山田博之, 川崎達也, 志馬伸朗, 土井研人, 江木盛時, 小倉裕司, 相原守夫, 田中裕, 西田修, 日本版敗血症診療ガイドライン2020特別委員会COVID-19対策タスクフォース

日本集中治療医学会雑誌（(一社)日本集中治療医学会） 28 （ Suppl.2 ） 296 - 296 2021年09月

ISSN 1340-7988

日本版敗血症ガイドライン2020;初期蘇生・ステロイドを知る敗血症に対するステロイド療法のエビデンス

福田龍将, 藤島清太郎, 升田好樹, 山元良, 遠藤功二, 竹下淳, 富永直樹, 河野浩幸, 名原功, 豊崎光信, 豊田幸樹年, 平野洋平, J-SSCG2020特別委員会

日本集中治療医学会雑誌（(一社)日本集中治療医学会） 28 （ Suppl.2 ） 226 - 226 2021年09月

ISSN 1340-7988

国内および海外のCOVID-19ガイドラインの動向

井村春樹, 山川一馬, 橋本英樹, 寺山毅郎, 山元良, 石原唯史, 石丸剛, 岡野弘, 成田知大, 真弓卓也, 安田英人, 山田浩平, 山田博之, 川崎達也, 志馬伸朗, 土井研人, 江木盛時, 小倉裕司, 相原守夫, 田中裕, 西田修, 日本版敗血症診療ガイドライン2020特別委員会COVID-19対策タスクフォース

日本集中治療医学会雑誌（(一社)日本集中治療医学会） 28 （ Suppl.2 ） 295 - 295 2021年09月

ISSN 1340-7988

COVID-19ガイドライン作成の意義

山川一馬, 橋本英樹, 寺山毅郎, 井村春樹, 山元良, 石原唯史, 石丸剛, 岡野弘, 成田知大, 真弓卓也, 安田英人, 山田浩平, 山田博之, 川崎達也, 志馬伸朗, 土井研人, 江木盛時, 小倉裕司, 相原守夫, 田中裕, 西田修, 日本版敗血症診療ガイドライン2020特別委員会COVID-19対策タスクフォース

日本集中治療医学会雑誌（(一社)日本集中治療医学会） 28 （ Suppl.2 ） 295 - 295 2021年09月

ISSN 1340-7988

COVID-19ガイドラインにおける各薬剤の推奨 CQ5(トシリズマブ)、CQ6(シクレソニド)、CQ7(抗凝固療法)

橋本英樹, 山川一馬, 寺山毅郎, 井村春樹, 山元良, 石原唯史, 石丸剛, 岡野弘, 成田知大, 真弓卓也, 安田英人, 山田浩平, 山田博之, 川崎達也, 志馬伸朗, 土井研人, 江木盛時, 小倉裕司, 相原守夫, 田中裕, 西田修, 日本版敗血症診療ガイドライン2020特別委員会COVID-19対策タスクフォース

日本集中治療医学会雑誌（(一社)日本集中治療医学会） 28 （ Suppl.2 ） 296 - 296 2021年09月

ISSN 1340-7988

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).

Egi M, Ogura H, Yatabe T, Atagi K, Inoue S, Iba T, Kakihana Y, Kawasaki T, Kushimoto S, Kuroda Y, Kotani J, Shime N, Taniguchi T, Tsuruta R, Doi K, Doi M, Nakada TA, Nakane M, Fujishima S, Hosokawa N, Masuda Y, Matsushima A, Matsuda N, Yamakawa K, Hara Y, Sakuraya M, Ohshimo S, Aoki Y, Inada M, Umemura Y, Kawai Y, Kondo Y, Saito H, Taito S, Takeda C, Terayama T, Tohira H, Hashimoto H, Hayashida K, Hifumi T, Hirose T, Fukuda T, Fujii T, Miura S, Yasuda H, Abe T, Andoh K, Iida Y, Ishihara T, Ide K, Ito K, Ito Y, Inata Y, Utsunomiya A, Unoki T, Endo K, Ouchi A, Ozaki M, Ono S, Katsura M, Kawaguchi A, Kawamura Y, Kudo D, Kubo K, Kurahashi K, Sakuramoto H, Shimoyama A, Suzuki T, Sekine S, Sekino M, Takahashi N, Takahashi S, Takahashi H, Tagami T, Tajima G, Tatsumi H, Tani M, Tsuchiya A, Tsutsumi Y, Naito T, Nagae M, Nagasawa I, Nakamura K, Nishimura T, Nunomiya S, Norisue Y, Hashimoto S, Hasegawa D, Hatakeyama J, Hara N, Higashibeppu N, Furushima N, Furusono H, Matsuishi Y, Matsuyama T, Minematsu Y, Miyashita R, Miyatake Y, Moriyasu M, Yamada T, Yamada H, Yamamoto R, Yoshida T, Yoshida Y, Yoshimura J, Yotsumoto R, Yonekura H, Wada T, Watanabe E, Aoki M, Asai H, Abe T, Igarashi Y, Iguchi N, Ishikawa M, Ishimaru G, Isokawa S, Itakura R, Imahase H, Imura H, Irinoda T, Uehara K, Ushio N, Umegaki T, Egawa Y, Enomoto Y, Ota K, Ohchi Y, Ohno T, Ohbe H, Oka K, Okada N, Okada Y, Okano H, Okamoto J, Okuda H, Ogura T, Onodera Y, Oyama Y, Kainuma M, Kako E, Kashiura M, Kato H, Kanaya A, Kaneko T, Kanehata K, Kano KI, Kawano H, Kikutani K, Kikuchi H, Kido T, Kimura S, Koami H, Kobashi D, Saiki I, Sakai M, Sakamoto A, Sato T, Shiga Y, Shimoto M, Shimoyama S, Shoko T, Sugawara Y, Sugita A, Suzuki S, Suzuki Y, Suhara T, Sonota K, Takauji S, Takashima K, Takahashi S, Takahashi Y, Takeshita J, Tanaka Y, Tampo A, Tsunoyama T, Tetsuhara K, Tokunaga K, Tomioka Y, Tomita K, Tominaga N, Toyosaki M, Toyoda Y, Naito H, Nagata I, Nagato T, Nakamura Y, Nakamori Y, Nahara I, Naraba H, Narita C, Nishioka N, Nishimura T, Nishiyama K, Nomura T, Haga T, Hagiwara Y, Hashimoto K, Hatachi T, Hamasaki T, Hayashi T, Hayashi M, Hayamizu A, Haraguchi G, Hirano Y, Fujii R, Fujita M, Fujimura N, Funakoshi H, Horiguchi M, Maki J, Masunaga N, Matsumura Y, Mayumi T, Minami K, Miyazaki Y, Miyamoto K, Murata T, Yanai M, Yano T, Yamada K, Yamada N, Yamamoto T, Yoshihiro S, Tanaka H, Nishida O

Journal of intensive care 9 （ 1 ） 53 2021年08月

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