Honma, Koichiro

写真a

Affiliation

School of Medicine, Department of Emergency and Critical Care Medicine （Shinanomachi）

Position

Assistant Professor/Senior Assistant Professor
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Academic Degrees 【 Display / hide 】

  • 医学博士, 慶應義塾大学

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Papers 【 Display / hide 】

  • Hydrogen gas distribution in organs after inhalation: Real-time monitoring of tissue hydrogen concentration in rat

    Yamamoto R., Homma K., Suzuki S., Sano M., Sasaki J.

    Scientific Reports （Scientific Reports)  9 （ 1 ）  2019.12

    　View Summary

    © 2019, The Author(s). Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a highly sensitive glass microsensor and continuous inhalation of 3% hydrogen gas. The hydrogen concentration was measured in the brain, liver, kidney, mesentery fat and thigh muscle of rats. The maximum concentration, time to saturation, and other measurements representing the dynamics of distribution were obtained from the concentration curves, and the results obtained for different organs were compared. The time to saturation was significantly longer (20.2 vs 6.3–9.4 min. P = 0.004 in all cases) and increased more gradually in muscle than in the other organs. The maximum concentration was the highest in liver and the lowest in the kidney (29.0 ± 2.6 vs 18.0 ± 2.2 μmol/L; P = 0.03 in all cases). The concentration varied significantly depending on the organ (P = 0.03). These results provide the fundamentals for elucidating the mechanisms underlying the in vivo favourable effects of hydrogen gas in mammalian systems.

  • Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

    Okubo K., Kurosawa M., Kamiya M., Urano Y., Suzuki A., Yamamoto K., Hase K., Homma K., Sasaki J., Miyauchi H., Hoshino T., Hayashi M., Mayadas T.N., Hirahashi J.

    Nature Medicine （Nature Medicine)  24 （ 2 ） 232 - 238 2018.02

    ISSN  10788956

    　View Summary

    Rhabdomyolysis is a serious syndrome caused by skeletal muscle injury and the subsequent release of breakdown products from damaged muscle cells into systemic circulation. The muscle damage most often results from strenuous exercise, muscle hypoxia, medications, or drug abuse and can lead to life-threatening complications, such as acute kidney injury (AKI). Rhabdomyolysis and the AKI complication can also occur during crush syndrome, an emergency condition that commonly occurs in victims of natural disasters, such as earthquakes, and man-made disasters, such as wars and terrorism. Myoglobin released from damaged muscle is believed to trigger renal dysfunction in this form of AKI. Recently, macrophages were implicated in the disease pathogenesis of rhabdomyolysis-induced AKI, but the precise molecular mechanism remains unclear. In the present study, we show that macrophages released extracellular traps (ETs) comprising DNA fibers and granule proteins in a mouse model of rhabdomyolysis. Heme-activated platelets released from necrotic muscle cells during rhabdomyolysis enhanced the production of macrophage extracellular traps (METs) through increasing intracellular reactive oxygen species generation and histone citrullination. Here we report, for the first time to our knowledge, this unanticipated role for METs and platelets as a sensor of myoglobin-derived heme in rhabdomyolysis-induced AKI. This previously unknown mechanism might be targeted for treatment of the disease. Finally, we found a new therapeutic tool for prevention of AKI after rhabdomyolysis, which might rescue some sufferers of this pathology.

  • 'Role of endothelium-derived hyperpolarizing factor in ACE inhibitor-induced renal vasodilation in vivo. Hypertension 43 (3): 603-609, 20'

    'Matsuda Hiroto, HAYASHI KOUICHI,　Wakino Shu,Kubota Eiji,　Honda Masanori,　Tokuyama Hirohumi, Takamatsu Iichiro, Tatematsu Satoru,　Saruta Takao'

    Hypertension 43 （ 3 ） 603-609 2004

    Research paper (scientific journal), Single Work

  • 早朝高血圧の特異的治療としての交感神経抑制薬の役割

    Honma Kouichirou, Kumagai Hiroo, Hayashi Kouichi, Saruta Takao

    今月の治療 11 （ 4 ） 430-435 2003.03

    Research paper (scientific journal), Joint Work

  • Altered renal microvascular response in Zucker obese rats

    Hayashi Koichi, Kanda Takeshi, Homma Koichiro, Tokuyama Hirobumi, Okubo Ken, Takamatsu Ichiro, Tatematsu Satoru, Kumagai Hiroo, Saruta Takao

    Metabolism 51 （ 12 ） 1553-1561 2002.12

    Research paper (scientific journal), Joint Work

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Presentations 【 Display / hide 】

  • アンジオテンシン抑制による蛋白尿減少作用の経時的比較検討

    Hayashi Kouichi，Honma Kouichirou，Kanda Takeshi，Saruta Takao

    第22回日本臨床薬理学会総会, 

    2001.12

  • 慢性腎炎におけるACE-IとARBの腎保護作用の長期比較検討

    Matsuda Hiroto，Honma Kouichirou，Hayashi Kouichi，Saruta Takao

    第5回日本心血管内分泌代謝学会総会, 

    2001.11

  • 食塩感受性ラットの腎微小循環における酸化ストレスの役割

    Kanda Takeshi，Hayashi Kouichi，Honma Kouichirou，Ozawa Yuri，Ookubo Ken，Takamatsu Ichirou，Tatematsu Satoru，Saruta Takao

    第5回日本心血管内分泌代謝学会総会, 

    2001.11

  • アンジオテンシン受容体拮抗薬の抗蛋白尿作用と降圧作用との関連

    Honma Kouichirou，Hayashi Kouichi，Ozawa Yuri，Matsuda Hiroto，Ookubo Ken，Takamatsu Ichirou，Kanda Takeshi，Saruta Takao

    第24回日本高血圧学会総会, 

    2001.10

  • Direct evidence for impaired endothelial function in renal microcirculation of acute hyperhomocysteinemia in vivo

    Okubo Ken, Hayashi Koichi, Honda Masanori, Tokuyama Hirobumi, Takamatsu Ichiro, Ozawa Yuri, Homma Koichiro, Saruta Takao

    Annual Meeting of American Society of Nephrology (34th ; 2001 ; San Francisco, CA, USA), 

    2001.10

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • iPS細胞とH2ガスを利用した網羅的アプローチよる急性腎障害への新規治療法の開発

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • リプログラミングによる皮下脂肪細胞から皮膚線維芽細胞への直接誘導法の開発

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, EMERGENCY MEDICINE

    2022

  • EMERGENCY MEDICINE AND NURSING

    2022

  • CLINICAL CLERKSHIP IN EMERGENCY MEDICINE

    2022

  • LECTURE SERIES, EMERGENCY MEDICINE

    2021

  • EMERGENCY MEDICINE AND NURSING

    2021

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