Kusumoto, Dai

写真a

Affiliation

School of Medicine, Center for Preventive Medicine (Shinanomachi)

Position

Instructor

 

Papers, etc., Registered in KOARA 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • Development of anti- atherosclerotic drugs using deep learning- based image analysis

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 楠本 大, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • The exploratory research to investigate the novel anti-atherosclerotic factor using iPS cells

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 楠本 大, Grant-in-Aid for Young Scientists (B), Principal Investigator

     View Summary

    Throughout our lives, we are exposed to cellular stress, which causes age-related diseases, such as metabolic syndromes, atherosclerosis, and cancer. Although we have evolved several innate protective mechanisms from cellular stress, the damage is often cumulative and irreversible. However, in rare cases, patients with strong chronic stress such as uncontrolled diabetes, exhibit minimal organ damage, suggesting that they would have strong innate protective mechanisms. Although there are several methods of genetic analysis, including genome-wide association study and exome sequencing, the vascular protective mechanisms are still unknown.
    In this study, we used the endothelial cells (ECs) derived from induced pluripotent stem cells (iPSCs) of severe diabetic patients with mild atherosclerosis to examine these innate protective mechanisms and explore a molecular target, to propose a novel vascular protective mechanism against cellular stresses.