Tsunoda, Kazuyuki



School of Medicine, Department of Dentistry and Oral Surgery (Shinanomachi)


Associate Professor

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Career 【 Display / hide

  • 1992.05

    慶應義塾大学医学部, 歯科・口腔外科, 研修医

  • 1994.05

    慶應義塾大学医学部, 歯科・口腔外科, 専修医

  • 1998.05

    慶應義塾大学医学部, 歯科・口腔外科, 助手

  • 1998.07

    慶應義塾大学医学部, 皮膚科, 助手

  • 2001.06

    慶應義塾大学医学部, 歯科・口腔外科, 助手

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Academic Background 【 Display / hide

  • 1986

    Tokyo Dental College, 歯学部

    University, Graduated

Academic Degrees 【 Display / hide

  • Doctor of Medical Science, Keio University, Dissertation, 2004.05

    尋常性天疱瘡モデルマウスを用いた病原性抗デスモグレイ ン3モノクローナル抗体作製とエピトープ解析

Licenses and Qualifications 【 Display / hide

  • 歯科医師免許.1992年06月, 1992.06

  • 日本口腔外科学会専門医, 2016.04

  • 日本口腔内科学会指導医, 2019.09

  • 日本有病者歯科医療学会指導医, 2015.03

  • 日本口腔科学会指導医, 2017.06

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Research Areas 【 Display / hide

  • Life Science / Surgical dentistry (Surgical Odontology)

Research Keywords 【 Display / hide

  • 口腔内科学

  • 口腔粘膜疾患

  • 自己免疫疾患

  • 自己免疫性水疱症

  • 造血幹細胞移植と口腔機能ケア

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Books 【 Display / hide

  • 皮膚科診療プラクティス 15難治性皮膚潰瘍を治すスキル

    角田和之、天谷雅行, 東京 文光堂, 2003.04

    Scope: 260-264

  • 臨床現場で役立つ”痛み”の教科書

    角田和之,, デンタルダイヤモンド社, 2020

  • 口腔粘膜・皮膚症状から「見抜く」全身疾患

    角田和之,, 南江堂, 2020

  • 口腔粘膜・皮膚症状から「見抜く」全身疾患

    角田和之,山上淳, 南江堂, 2020

  • 口腔粘膜・皮膚症状から「見抜く」全身疾患

    池浦一裕,角田和之, 南江堂, 2020

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Papers 【 Display / hide

  • 自己免疫性水疱症による粘膜病変


    (全日本病院出版会)  304   69 - 75 2021.01

    ISSN  978-4-86519-636-8

  • 一般的な口腔粘膜疾患を知ろう


    (デンタルダイヤモンド社)  46   103 - 106 2021

  • Value of labial salivary gland histopathology for diagnosis of Sjögren's syndrome in patients with anti-centromere antibody positivity

    Tsukamoto, Masako Suzuki, Katsuya Tsunoda, Kazuyuki Ikeura, Kazuhiro Kameyama, Kaori Takeuchi, Tsutomu

    International Journal of Rheumatic Diseases 23   1024 - 1029 2020

    Research paper (scientific journal), Joint Work, Accepted

  • Takeshita, M. Suzuki, K. Kaneda, Y. Yamane, H. Ikeura, K. Sato, H. Kato, S. Tsunoda, K. Arase, H. Takeuchi, T.

    Antigen-driven selection of antibodies against SSA, SSB and the centromere 'complex', including a novel antigen, MIS12 complex, in human salivary glands

    Annals of the Rheumatic Diseases 79 ( 1 ) 150 - 158 2020

    Research paper (scientific journal), Joint Work, Accepted

  • Anti-centromere antibodies target centromere–kinetochore macrocomplex: a comprehensive autoantigen profiling

    ajio, Nobuhiko Takeshita, Masaru Suzuki, Katsuya Kaneda, Yukari Yamane, Humitsugu Ikeura, Kazuhiro Sato, Hidekazu Kato, Shin Shimizu, Hiroyuki Tsunoda, Kazuyuki Takeuchi, Tsutomu

    Annals of the Rheumatic Diseases 80 ( 5 ) 651 - 659 2020

    Research paper (scientific journal), Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

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Presentations 【 Display / hide

  • ラット口内炎モデルを用いた半夏瀉心湯の臨床効果に関する検討と臨床応用

    小澤 夏生, 本多 佑名, 林 宰央, 恩田 健志, 池浦 一裕, 藤田 康平, 角田 和之, 永井 哲夫, 中川 種昭




  • 【嚥下障害と誤嚥性肺炎】誤嚥性肺炎に対する対応 誤嚥性肺炎の予防

    角田 和之, 池浦 一裕

    Clinical Neuroscience, 



  • 難治性口腔咽頭潰瘍を伴った腸管ベーチェット病の一例

    小池 将人, 池浦 一裕, 藤田 康平, 加藤 伸, 黄地 健仁, 宮下 英高, 角田 和之, 中川 種昭




  • Laugier-Hunziker-Baran症候群の一例

    金生 茉莉, 藤田 康平, 加藤 伸, 池浦 一裕, 中川 種昭, 角田 和之




  • 同種造血幹細胞移植周術期における唾液腺機能の臨床的検討

    工藤 葉子, 池浦 一裕, 藤田 康平, 佐藤 英和, 加藤 伸, 加藤 淳, 森 毅彦, 中川 種昭, 角田 和之




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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Analysis of severity of oral mucosal lesions in paraneoplastic pemphigus using disease model mice


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

  • 培養細胞評価系を用いた腫瘍随伴性天疱瘡における自己抗体病原性の解析


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 3D analysis of the oral mucosa epithelium barrier function


    Keio University, KATO SHIN, SATO Hidekazu, AMAGAI Masayuki, KUBO Ryouji, FUJITA KOHEI, Grant-in-Aid for Challenging Exploratory Research, No Setting

     View Summary

    On the basis of the reported cofocus microscope and observation method of the tight junction in the mouse auricle epithelium using the 3D construction software, I examined a condition such as one of reagent density so far at dyeing time to establish the observation method of the tight junction suitable for an oral mucosa epithelium more. As a result, observation of ZO-1 which was Claudin-1 which was the constitution protein of the tight junction of the mouse oral mucosa than a conventional method more clearly, Claudin-4 and lining protein was enabled by increasing primary dyeing time.

  • Development of pathogenic activity of pemphigus using transgenic mice


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

     View Summary

    Pemphigus is an autoimmune blistering disease of skin and oral mucosa. The all of patients with pemphigus vulgaris have a blister in oral mucosa. Many of cases, pathogenic activity of the autoantibody correlate with clinical phenotype of the pemphigus, and it is confirmed their correlation. However, there are many cases that severity of clinical phenotype does not correlate with antibody titers. Therefore, we tried to develop a novel system to measure the pathogenic activity of the pemphigus autoantibody in this study.

  • development of therapeutic strategy and analysis of pathophysiology of pemphigus using autoantigen specific IgM monoclonal natibody


    Keio University, KAZUYUKI tsunoda, NAKAGAWA Taneaki, KATO Shin, KODAKA Rie, Grant-in-Aid for Scientific Research (C), No Setting

     View Summary

    e analyzed the anti-Dsg3 IgM antibody in pemphigus. In early stage of pemphigus patient serums, apparent anti-Dsg3IgM antibody was not detected. In PV model mice, anti-Dsg3 IgM antibody production in the early stage of the onset of PV was confirmed, however it was not significant than anti-Dsg3 IgG antibody production.Furthermore, we conducted examination for in vivo and in vitro analysis. The in vitro dissociation assay using normal human culture keratinocyte and the passive transfer assay using mouse were performed to confirm the preventive effect and therapeutic effect of the anti-Dsg3 IgM antibody. There are no apparent differences between subjects and controls for both effects. The detailed and continuous examination will be necessary in future. These results are useful for dissection of pathophysiology of PV and development of therapeutic strategy of PV.

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Intellectual Property Rights, etc. 【 Display / hide

  • pemphigus monoclonal antibody

    Date announced: 第3817587号   

    Patent, Joint

Awards 【 Display / hide

  • The Award for best poster presentaiton

    TSUNODA KAZUYUKI, 2010.09, Society for cutaneous ultrastructure research, KERATIN 13 GENE MUTATION CAUSES ORAL WHITE SPONGE NEVUS

    Type of Award: International academic award (Japan or overseas)


Courses Taught 【 Display / hide



  • 歯科学講義

    2018, Lecture

  • 歯科学講義

    2017, Lecture

  • 歯科学講義

    2016, Lecture



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