相馬 智也 (ソウマ トモヤ)

Soma, Tomoya



医学部 歯科・口腔外科学教室 (信濃町)




経歴 【 表示 / 非表示

  • 2021年04月

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教(有期・医学部)

  • 2020年04月

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教(臨床実習)

  • 2018年04月

    慶應義塾大学, 大学院医学研究科, 助教(有期・研究奨励Ⅲ)

  • 2015年04月

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教

  • 2013年04月

    がん・感染症センター都立駒込病院, 歯科口腔外科, 非常勤医員(常勤的)

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学歴 【 表示 / 非表示

  • 2003年04月

    日本歯科大学, 歯学部

    大学, 卒業

  • 2017年04月

    慶應義塾大学, 大学院医学研究科

    大学院, 修了, 博士

学位 【 表示 / 非表示

  • 博士(医学), 慶應義塾大学, 課程, 2021年03月

    Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

免許・資格 【 表示 / 非表示

  • (公社)日本口腔外科学会認定口腔外科認定医, 2015年04月

  • (公社)日本化学療法学会認定抗菌化学療法認定歯科医師, 2016年01月

  • (公社)日本口腔外科学会認定口腔外科専門医, 2020年04月

  • 日本がん治療認定医機構がん治療認定医 (歯科口腔外科), 2021年04月

  • ICD制度協議会認定ICD(Infection Control Doctor), 2022年01月


研究分野 【 表示 / 非表示

  • ライフサイエンス / 外科系歯学

研究キーワード 【 表示 / 非表示

  • 薬剤関連顎骨壊死

  • 骨代謝学

  • Patient-dervied xenografts

  • 口腔癌

  • 頭頚部癌


著書 【 表示 / 非表示

論文 【 表示 / 非表示

  • Hao1 Is Not a Pathogenic Factor for Ectopic Ossifications but Functions to Regulate the TCA Cycle In Vivo

    Atsushi Kimura, Akiyoshi Hirayama, Tatsuaki Matsumoto, Yuiko Sato, Tami Kobayashi, Satsuki Ikeda, Midori Maruyama, Mari Kaneko, Mayo Shigeta, Eri Ito, Tomoya Soma, Kana Miyamoto, Tomoyoshi Soga, Masaru Tomita, Akihito Oya, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto

    Metabolites (MDPI AG)  12 ( 1 ) 82 - 82 2022年01月

    研究論文(学術雑誌), 共著, 査読有り


    Ossification of the posterior longitudinal ligament (OPLL), a disease characterized by the ectopic ossification of a spinal ligament, promotes neurological disorders associated with spinal canal stenosis. While blocking ectopic ossification is mandatory to prevent OPLL development and progression, the mechanisms underlying the condition remain unknown. Here we show that expression of hydroxyacid oxidase 1 (Hao1), a gene identified in a previous genome-wide association study (GWAS) as an OPLL-associated candidate gene, specifically and significantly decreased in fibroblasts during osteoblast differentiation. We then newly established Hao1-deficient mice by generating Hao1-flox mice and crossing them with CAG-Cre mice to yield global Hao1-knockout (CAG-Cre/Hao1flox/flox; Hao1 KO) animals. Hao1 KO mice were born normally and exhibited no obvious phenotypes, including growth retardation. Moreover, Hao1 KO mice did not exhibit ectopic ossification or calcification. However, urinary levels of some metabolites of the tricarboxylic acid (TCA) cycle were significantly lower in Hao1 KO compared to control mice based on comprehensive metabolomic analysis. Our data indicate that Hao1 loss does not promote ectopic ossification, but rather that Hao1 functions to regulate the TCA cycle in vivo.

  • Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics

    Tomoya Soma, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Eri Ito, Tatsuaki Matsumoto, Atsushi Kimura, Kana Miyamoto, Morio Matsumoto, Masaya Nakamura, Mayu Morita, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Takeshi Miyamoto

    Scientific Reports (Springer Science and Business Media LLC)  12 ( 1 ) 19 2022年01月

    研究論文(学術雑誌), 共著, 査読有り


    <title>Abstract</title>Invasive dental treatment such as tooth extraction following treatment with strong anti-bone resorptive agents, including bisphosphonates and denosumab, reportedly promotes osteonecrosis of the jaw (ONJ) at the extraction site, but strategies to prevent ONJ remain unclear. Here we show that in mice, administration of either active vitamin D analogues, antibiotics or anti-inflammatory agents can prevent ONJ development induced by tooth extraction during treatment with the bisphosphonate zoledronate. Specifically, tooth extraction during treatment with zoledronate induced osteonecrosis in mice, but administration of either 1,25(OH)2D3 or ED71, both active vitamin D analogues, significantly antagonized osteonecrosis development, even under continuous zoledronate treatment. 1,25(OH)2D3 or ED71 administration also significantly inhibited osteocyte apoptosis induced by tooth extraction and bisphosphonate treatment. Administration of either active vitamin D analogue significantly inhibited elevation of serum inflammatory cytokine levels in mice in response to injection of lipopolysaccharide, an infection mimetic. Furthermore, administration of either anti-inflammatory or antibiotic reagents significantly blocked ONJ development following tooth extraction and zoledronate treatment. These findings suggest that administration of active vitamin D, anti-inflammatory agents or antibiotics could prevent ONJ development induced by tooth extraction in patients treated with zoledronate.

  • Remarkable response of diffuse sclerosing osteomyelitis of the mandible to zoledronate by single infusion without prior treatment of other bisphosphonates

    Yamada M., Iwata S., Nishi K., Ochiai S., Araki D., Soma T., Yamada Y., Miyashita H., Suga K., Asoda S.

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)  2022年

    査読有り,  ISSN  22125558


    Diffuse sclerosing osteomyelitis of the mandible (DSOM) is a nonsuppurative osteomyelitis mainly characterized by recurrent local mandibular swelling and pain. Because of the unknown pathophysiological mechanism underlying DSOM, treatment can be challenging. Reported treatment options include long-term analgesic medication, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, corticosteroids, hyperbaric oxygen, and surgical treatment. However, these treatments cannot reliably lead to a long-lasting reduction of complaints. Recently, bisphosphonates has been reported effective in managing DSOM. We herein report a case of DSOM with a favorable response to a single infusion of zoledronate without prior treatment of other bisphosphonates. The patient was a 19-year-old woman who visited our hospital complaining of swelling and remarkable spontaneous pain in the right mandibular angle region. Under the diagnosis of osteomyelitis of the mandible, the clinical symptoms were improved by administering an antimicrobial agent and anti-inflammatory analgesic, but computed tomography (CT) showed exacerbation of bone resorption. A biopsy showed fibrosis between the bone tissue and trabeculae, a finding consistent with post-inflammatory changes. 99mTc scintigraphy showed an abnormal accumulation in the right mandibular ramus. Based on these results, she was diagnosed with DSOM. As a result of discussing with the physician in charge of internal medicine, it became the policy of the bisphosphonates and the intravenous administration of zoledronate 4 mg was enforced. Her bone sclerosis and bone resorption showed an improving trend on CT three months after the zoledronate administration, and there have been no symptoms or exacerbation of findings in three years since the administration.

  • Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring

    Eri Ito, Yuiko Sato, Tami Kobayashi, Tomoya Soma, Tatsuaki Matsumoto, Atsushi Kimura, Kana Miyamoto, Hideo Matsumoto, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto

    Bone (Elsevier BV)  153   116133 - 116133 2021年12月

    研究論文(学術雑誌), 共著, 査読有り,  ISSN  8756-3282


    Changes in bone metabolism occur in mothers during pregnancy or lactation that may decrease bone mass and result in fragility fractures after partum. However, use of drugs during pregnancy or lactation to counteract these effects is often prohibited or strongly discouraged. Therefore, approaches to protect mothers from fragility fractures have not been established. Here we show that bone mineral density was significantly lower in female mice after partum than in age-matched female mice without partum. We also show that temporary administration of the bisphosphonate alendronate, either just before or just after pregnancy, to female mice was protective against bone loss due to pregnancy or lactation and had no adverse effects on offspring, such as growth retardation. Furthermore, we show that alendronate administration to female mice during lactation was effective in increasing bone mass in mothers without promoting bone abnormalities or growth retardation in offspring. Calcium levels in milk from female mice administered alendronate during lactation were equivalent to those in milk from mothers not treated with alendronate. Overall, we propose that alendronate administration to mothers could prevent bone loss and fragility fractures during pregnancy and lactation.

  • Clinical value of entire-circumferential intraoperative frozen section analysis for the complete resection of superficial squamous cell carcinoma of the tongue.

    Asoda S, Miyashita H, Soma T, Munakata K, Yamada Y, Yasui Y, Kudo Y, Usuda S, Hasegawa T, Nakagawa T, Kawana H

    Oral oncology (Elsevier BV)  123   105629 - 105629 2021年11月

    研究論文(学術雑誌), 共著, 査読有り,  ISSN  1368-8375


    Objectives: We aimed to evaluate the clinical value of an entire-circumferential intraoperative frozen section analysis (e-IFSA) for the complete resection of superficial squamous cell carcinoma (SCC) of the tongue. Materials and Methods: A total 276 specimens from 51 patients with pT1-2, N0, mucosal or submucosal invasion SCC were analyzed to evaluate the diagnostic accuracy of the e-IFSA and the added value of the e-IFSA to iodine staining. The e-IFSA results were compared with the final histologic results obtained using permanent sections. All specimens for the e-IFSA were taken over the entire circumference 5 mm outside from the iodine unstained areas. The outline of the main resected specimen after taking these outer mucosal specimens were defined as the surgical margins determined by iodine staining alone. Results: The e-IFSA results were in excellent agreement with final histological results (Cohen's kappa value: 0.85) and the e-IFSA showed high sensitivity (100%) and high negative predictive value (100%). The actual complete resection rate with an e-IFSA was 100% (51/51), and no patient required additional resection after surgery. In contrast, 10/51 patients (20%) patients showed residual atypical mucosal epithelium at or beyond the margin determined by iodine staining alone; this difference was statistically significant (P = 0.002). The 5-year local control rate and 5-year overall survival rate after this procedure were both 100%. Conclusion: An e-IFSA has additional value when performed in conjunction with iodine staining. An e-IFSA would be useful for achieving complete resection of superficial SCC of the tongue.

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総説・解説等 【 表示 / 非表示

  • 【GPの疑問に答える!歯科小手術の勘どころ】粘液嚢胞・エプーリスの除去を安全に行うには?

    相馬 智也

    DENTAL DIAMOND ((株)デンタルダイヤモンド社)  47 ( 3 ) 45 - 49 2022年02月

    ISSN  0386-2305

  • 口腔扁平上皮癌においてFOXA1発現はxCT依存的腫瘍成長を抑制する

    岡崎 章悟, 中野 友暉, 吉川 桃子, 相馬 智也, 莇生田 整治, 後飯塚 僚, 佐谷 秀行, 永野 修

    日本癌学会総会記事 ((一社)日本癌学会)  80回   [E11 - 2 2021年09月

    ISSN  0546-0476

研究発表 【 表示 / 非表示

  • Zoledronate投与マウスにおける顎骨壊死はビタミンDの投与により抑制される

    相馬智也, 森田麻友, 岩崎良太郎, 莇生田整治, 中川種昭, 宮本健史




  • 上顎骨に生じた脱分化型傍骨性骨肉腫の一例

    小池 将人, 宮下 英高, 金生 茉莉, 宗像 花楠子, 相馬 智也, 山田 有佳, 莇生田 整治, 河奈 裕正, 中川 種昭




  • Crowned dens syndromeを合併した急性歯性感染症の1例

    今西俊喜, 相馬智也, 木村萌美, 宗像花楠子, 宮下英高, 河奈裕正, 中川種昭, 莇生田整治




  • 下顎前歯の先天性欠損に対しインプラント治療と歯科矯正治療を併用した1例

    米山かや, 相馬智也, 堀江伸行, 宮下英高, 宗像花楠子, 小高利絵, 河奈裕正, 中川種昭, 莇生田整治



    ポスター発表, (公社)日本顎顔面インプラント学会

  • 同種造血幹細胞移植後の長期経過観察中に舌腫瘍を生じた2例

    臼田聡, 莇生田整治, 相馬智也, 藤田康平, 池浦一裕, 加藤淳, 角田和之, 中川種昭




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競争的研究費の研究課題 【 表示 / 非表示

  • CD73(+)MSCs集積機能型歯周炎・インプラント周囲炎抗菌再建デバイスの開発


    日本学術振興会, 科学研究費助成事業 基盤研究(C), 森川 暁, 相馬 智也, 宮下 英高, 基盤研究(C), 研究分担者



  • 炎症性サイトカイン制御による骨破壊性疾患における抗炎症性作用機序の解明


    文部科学省・日本学術振興会, 科学研究費助成事業, 相馬 智也, 研究活動スタート支援, 補助金,  研究代表者



受賞 【 表示 / 非表示

  • 第75回日本口腔科学会学術集会 Rising Scientist賞

    相馬智也, 2021年05月, ゾレドロネート投与と侵襲的歯科処置は,炎症性サイトカインを上昇させ,骨吸収薬剤関連顎骨壊死を誘発する

    受賞区分: 国内学会・会議・シンポジウム等の賞

  • 第5回日本骨免疫学会 優秀演題賞

    相馬智也, 2019年06月, 骨吸収抑制薬による薬剤関連顎骨壊死には炎症性サイトカインの上昇が必須である

    受賞区分: 国内学会・会議・シンポジウム等の賞


所属学協会 【 表示 / 非表示

  • 日本口腔外科学会

  • 日本口腔腫瘍学会

  • 日本化学療法学会

  • 日本歯科薬物療法学会

  • 日本顎顔面インプラント学会


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