Soma, Tomoya

写真a

Affiliation

School of Medicine, Department of Dentistry and Oral Surgery (Shinanomachi)

Position

Instructor

External Links

Career 【 Display / hide

  • 2021.04
    -
    Present

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教(有期・医学部)

  • 2020.04
    -
    2021.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教(臨床実習)

  • 2018.04
    -
    2020.03

    慶應義塾大学, 大学院医学研究科, 助教(有期・研究奨励Ⅲ)

  • 2015.04
    -
    2018.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教

  • 2013.04
    -
    2015.03

    がん・感染症センター都立駒込病院, 歯科口腔外科, 非常勤医員(常勤的)

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Academic Background 【 Display / hide

  • 2003.04
    -
    2009.03

    The Nippon Dental University, Faculty of Dentistry

    University, Graduated

  • 2017.04
    -
    2021.03

    Keio University, Graduate School of Medicine, Keio University

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • Ph.D.in Medicine, Keio University, Coursework, 2021.03

    Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

Licenses and Qualifications 【 Display / hide

  • (公社)日本口腔外科学会認定口腔外科認定医, 2015.04

  • (公社)日本化学療法学会認定抗菌化学療法認定歯科医師, 2016.01

  • (公社)日本口腔外科学会認定口腔外科専門医, 2020.04

  • 日本がん治療認定医機構がん治療認定医 (歯科口腔外科), 2021.04

  • ICD制度協議会認定ICD(Infection Control Doctor), 2022.01

 

Research Areas 【 Display / hide

  • Life Science / Surgical dentistry

Research Keywords 【 Display / hide

  • 薬剤関連顎骨壊死

  • 骨代謝学

  • Patient-dervied xenografts

  • Oral cancer

  • Head and Neck Cancer

 

Books 【 Display / hide

Papers 【 Display / hide

  • Hao1 Is Not a Pathogenic Factor for Ectopic Ossifications but Functions to Regulate the TCA Cycle In Vivo

    Atsushi Kimura, Akiyoshi Hirayama, Tatsuaki Matsumoto, Yuiko Sato, Tami Kobayashi, Satsuki Ikeda, Midori Maruyama, Mari Kaneko, Mayo Shigeta, Eri Ito, Tomoya Soma, Kana Miyamoto, Tomoyoshi Soga, Masaru Tomita, Akihito Oya, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto

    Metabolites (MDPI AG)  12 ( 1 ) 82 - 82 2022.01

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    Ossification of the posterior longitudinal ligament (OPLL), a disease characterized by the ectopic ossification of a spinal ligament, promotes neurological disorders associated with spinal canal stenosis. While blocking ectopic ossification is mandatory to prevent OPLL development and progression, the mechanisms underlying the condition remain unknown. Here we show that expression of hydroxyacid oxidase 1 (Hao1), a gene identified in a previous genome-wide association study (GWAS) as an OPLL-associated candidate gene, specifically and significantly decreased in fibroblasts during osteoblast differentiation. We then newly established Hao1-deficient mice by generating Hao1-flox mice and crossing them with CAG-Cre mice to yield global Hao1-knockout (CAG-Cre/Hao1flox/flox; Hao1 KO) animals. Hao1 KO mice were born normally and exhibited no obvious phenotypes, including growth retardation. Moreover, Hao1 KO mice did not exhibit ectopic ossification or calcification. However, urinary levels of some metabolites of the tricarboxylic acid (TCA) cycle were significantly lower in Hao1 KO compared to control mice based on comprehensive metabolomic analysis. Our data indicate that Hao1 loss does not promote ectopic ossification, but rather that Hao1 functions to regulate the TCA cycle in vivo.

  • Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics

    Tomoya Soma, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Eri Ito, Tatsuaki Matsumoto, Atsushi Kimura, Kana Miyamoto, Morio Matsumoto, Masaya Nakamura, Mayu Morita, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Takeshi Miyamoto

    Scientific Reports (Springer Science and Business Media LLC)  12 ( 1 ) 19 2022.01

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    <title>Abstract</title>Invasive dental treatment such as tooth extraction following treatment with strong anti-bone resorptive agents, including bisphosphonates and denosumab, reportedly promotes osteonecrosis of the jaw (ONJ) at the extraction site, but strategies to prevent ONJ remain unclear. Here we show that in mice, administration of either active vitamin D analogues, antibiotics or anti-inflammatory agents can prevent ONJ development induced by tooth extraction during treatment with the bisphosphonate zoledronate. Specifically, tooth extraction during treatment with zoledronate induced osteonecrosis in mice, but administration of either 1,25(OH)<sub>2</sub>D<sub>3</sub> or ED71, both active vitamin D analogues, significantly antagonized osteonecrosis development, even under continuous zoledronate treatment. 1,25(OH)<sub>2</sub>D<sub>3</sub> or ED71 administration also significantly inhibited osteocyte apoptosis induced by tooth extraction and bisphosphonate treatment. Administration of either active vitamin D analogue significantly inhibited elevation of serum inflammatory cytokine levels in mice in response to injection of lipopolysaccharide, an infection mimetic. Furthermore, administration of either anti-inflammatory or antibiotic reagents significantly blocked ONJ development following tooth extraction and zoledronate treatment. These findings suggest that administration of active vitamin D, anti-inflammatory agents or antibiotics could prevent ONJ development induced by tooth extraction in patients treated with zoledronate.

  • Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring.

    Eri Ito, Yuiko Sato, Tami Kobayashi, Tomoya Soma, Tatsuaki Matsumoto, Atsushi Kimura, Kana Miyamoto, Hideo Matsumoto, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto

    Bone (Elsevier BV)  153   116133 - 116133 2021.12

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  8756-3282

     View Summary

    Changes in bone metabolism occur in mothers during pregnancy or lactation that may decrease bone mass and result in fragility fractures after partum. However, use of drugs during pregnancy or lactation to counteract these effects is often prohibited or strongly discouraged. Therefore, approaches to protect mothers from fragility fractures have not been established. Here we show that bone mineral density was significantly lower in female mice after partum than in age-matched female mice without partum. We also show that temporary administration of the bisphosphonate alendronate, either just before or just after pregnancy, to female mice was protective against bone loss due to pregnancy or lactation and had no adverse effects on offspring, such as growth retardation. Furthermore, we show that alendronate administration to female mice during lactation was effective in increasing bone mass in mothers without promoting bone abnormalities or growth retardation in offspring. Calcium levels in milk from female mice administered alendronate during lactation were equivalent to those in milk from mothers not treated with alendronate. Overall, we propose that alendronate administration to mothers could prevent bone loss and fragility fractures during pregnancy and lactation.

  • Clinical value of entire-circumferential intraoperative frozen section analysis for the complete resection of superficial squamous cell carcinoma of the tongue

    Seiji Asoda, Hidetaka Miyashita, Tomoya Soma, Kanako Munakata, Yuka Yamada, Yuta Yasui, Yoko Kudo, Shin Usuda, Toshihiro Hasegawa, Taneaki Nakagawa, Hiromasa Kawana

    Oral Oncology (Elsevier BV)  123   105629 - 105629 2021.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1368-8375

     View Summary

    Objectives: We aimed to evaluate the clinical value of an entire-circumferential intraoperative frozen section analysis (e-IFSA) for the complete resection of superficial squamous cell carcinoma (SCC) of the tongue. Materials and Methods: A total 276 specimens from 51 patients with pT1-2, N0, mucosal or submucosal invasion SCC were analyzed to evaluate the diagnostic accuracy of the e-IFSA and the added value of the e-IFSA to iodine staining. The e-IFSA results were compared with the final histologic results obtained using permanent sections. All specimens for the e-IFSA were taken over the entire circumference 5 mm outside from the iodine unstained areas. The outline of the main resected specimen after taking these outer mucosal specimens were defined as the surgical margins determined by iodine staining alone. Results: The e-IFSA results were in excellent agreement with final histological results (Cohen's kappa value: 0.85) and the e-IFSA showed high sensitivity (100%) and high negative predictive value (100%). The actual complete resection rate with an e-IFSA was 100% (51/51), and no patient required additional resection after surgery. In contrast, 10/51 patients (20%) patients showed residual atypical mucosal epithelium at or beyond the margin determined by iodine staining alone; this difference was statistically significant (P = 0.002). The 5-year local control rate and 5-year overall survival rate after this procedure were both 100%. Conclusion: An e-IFSA has additional value when performed in conjunction with iodine staining. An e-IFSA would be useful for achieving complete resection of superficial SCC of the tongue.

  • Adipose-Derived Stem Cell Sheets Improve Early Biomechanical Graft Strength in Rabbits After Anterior Cruciate Ligament Reconstruction.

    Tatsuaki Matsumoto, Yuiko Sato, Tami Kobayashi, Kunika Suzuki, Atsushi Kimura, Tomoya Soma, Eri Ito, Toshiyuki Kikuchi, Shu Kobayashi, Kengo Harato, Yasuo Niki, Morio Matsumoto, Masaya Nakamura, Takeshi Miyamoto

    The American journal of sports medicine (American Journal of Sports Medicine)  49 ( 13 ) 3635465211041582 - 3635465211041582 2021.10

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0363-5465

     View Summary

    BACKGROUND: Although various reconstruction techniques are available for anterior cruciate ligament (ACL) injuries, a long recovery time is required before patients return to sports activities, as the reconstructed ACL requires time to regain strength. To date, several studies have reported use of mesenchymal stem cells in orthopaedic surgery; however, no studies have used adipose-derived stem cell (ADSC) sheets in ACL reconstruction (ACLR). HYPOTHESIS: ADSC sheet transplantation can improve biomechanical strength of the autograft used in ACLR. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 68 healthy Japanese white rabbits underwent unilateral ACLR with a semitendinosus tendon autograft after random enrollment into a control group (no sheet; n = 34) and a sheet group (ADSC sheet; n = 34). At 2, 4, 8, 16, and 24 weeks after surgery, rabbits in each group were sacrificed to evaluate tendon-bone healing using histological staining, micro-computed tomography, and biomechanical testing. At 24 weeks, scanning transmission electron microscopy of the graft midsubstance was performed. RESULTS: The ultimate failure load for the control and sheet groups, respectively, was as follows: 17.2 ± 5.5 versus 37.3 ± 10.3 (P = .01) at 2 weeks, 28.6 ± 1.9 versus 47.4 ± 10.4 (P = .003) at 4 weeks, 53.0 ± 14.3 versus 48.1 ± 9.3 (P = .59) at 8 weeks, 66.2 ± 9.3 versus 95.2 ± 43.1 (P = .24) at 16 weeks, and 66.7 ± 27.3 versus 85.3 ± 29.5 (P = .39) at 24 weeks. The histological score was also significantly higher in the sheet group compared with the control group at early stages up to 8 weeks. On micro-computed tomography, relative to the control group, the bone tunnel area was significantly narrower in the sheet group at 4 weeks, and the bone volume/tissue volume of the tendon-bone interface was significantly greater at 24 weeks. Scanning transmission electron microscopy at 24 weeks indicated that the mean collagen fiber diameter in the midsubstance was significantly greater, as was the occupation ratio of collagen fibers per field of view, in the sheet group. CONCLUSION: ADSC sheets improved biomechanical strength, prevented bone tunnel enlargement, and promoted tendon-bone interface healing and graft midsubstance healing in an in vivo rabbit model. CLINICAL RELEVANCE: ADSC sheets may be useful for early tendon-bone healing and graft maturation in ACLR.

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Reviews, Commentaries, etc. 【 Display / hide

  • 【GPの疑問に答える!歯科小手術の勘どころ】粘液嚢胞・エプーリスの除去を安全に行うには?

    相馬 智也

    DENTAL DIAMOND ((株)デンタルダイヤモンド社)  47 ( 3 ) 45 - 49 2022.02

    ISSN  0386-2305

  • 口腔扁平上皮癌においてFOXA1発現はxCT依存的腫瘍成長を抑制する

    岡崎 章悟, 中野 友暉, 吉川 桃子, 相馬 智也, 莇生田 整治, 後飯塚 僚, 佐谷 秀行, 永野 修

    日本癌学会総会記事 ((一社)日本癌学会)  80回   [E11 - 2 2021.09

    ISSN  0546-0476

Presentations 【 Display / hide

  • A case of dedifferentiated parosteal osteosarcoma of the maxilla

    Masato Koike, Hidetaka Miyashita, Mari Kinsho, Kanako Munakata, Tomoya Soma, Yuka Yamada, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa

    The 40th Annual Meeting of Japanese Society of Oral Oncology, 

    2022.02
    -
    2022.03

    Poster presentation

  • Crowned dens syndromeを合併した急性歯性感染症の1例

    今西俊喜, 相馬智也, 木村萌美, 宗像花楠子, 宮下英高, 河奈裕正, 中川種昭, 莇生田整治

    第212回(公社)日本口腔外科学会関東支部学術集会, 

    2021.12

    Oral presentation (general)

  • A case of congenital missing teeth in the mandibular anterior region managed with orthodontic treatment followed by prosthodontic treatment using an implant

    米山かや, 相馬智也, 堀江伸行, 宮下英高, 宗像花楠子, 小高利絵, 河奈裕正, 中川種昭, 莇生田整治

    A case of congenital missing teeth in the mandibular anterior region managed with orthodontic treatment followed by prosthodontic treatment using an implant, 

    2021.12

    Poster presentation, (公社)日本顎顔面インプラント学会

  • 同種造血幹細胞移植後の長期経過観察中に舌腫瘍を生じた2例

    臼田聡, 莇生田整治, 相馬智也, 藤田康平, 池浦一裕, 加藤淳, 角田和之, 中川種昭

    日本がん口腔支持療法学会第7回学術大会, 

    2021.12

    Poster presentation

  • 外科療法を実施した薬剤関連顎骨壊死患者のQOL調査

    宗像 花楠子, 宮下 英高, 山田 有佳, 岩崎良太郎, 堀江伸行, 金生茉莉, 相馬 智也, 中川 種昭, 莇生田 整治

    第66回(公社)日本口腔外科学会総会・学術大会, 

    2021.11

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 炎症性サイトカイン制御による骨破壊性疾患における抗炎症性作用機序の解明

    2021.08
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up , Principal investigator

     View Summary

    ビタミンDの生理的作用は、多岐にわたるが、われわれは、炎症性骨破壊疾患に注目した。口腔内は、細菌が常に存在する空間であり、急性・慢性疾患を問わず人間が、炎症性口腔内疾患に罹患する。骨吸収薬剤関連顎骨壊死を代表とする顎骨の骨破壊性疾患に罹患すると審美性、食事の摂取などを含めた機能性を損ない、QOLが著しく低下する。本研究により炎症性サイトカイン制御による新たな炎症性骨破壊疾患の治療法を見出す可能性が考えられる。

Awards 【 Display / hide

  • 第75回日本口腔科学会学術集会 Rising Scientist賞

    相馬智也, 2021.05, ゾレドロネート投与と侵襲的歯科処置は,炎症性サイトカインを上昇させ,骨吸収薬剤関連顎骨壊死を誘発する

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • 第5回日本骨免疫学会 優秀演題賞

    Tomoya Soma, 2019.06, 骨吸収抑制薬による薬剤関連顎骨壊死には炎症性サイトカインの上昇が必須である

    Type of Award: Award from Japanese society, conference, symposium, etc.

 

Memberships in Academic Societies 【 Display / hide

  • Japanese Society of Oral and Maxillofacial Surgeons

     
  • Japanese Society of Oral Oncology

     
  • Japanese Society of Chemotherapy

     
  • Japanese Society of Oral Therapeutics and Pharmacology

     
  • Japanese Academy of Maxillofacial Implants

     

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