SOMA Tomoya

写真a

Affiliation

School of Medicine, Department of Dentistry and Oral Surgery （Shinanomachi）

Position

Instructor

External Links
Page Top ▲

Career 【 Display / hide 】

  • 2021.04
    -
    Present

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（有期・医学部）

  • 2020.04
    -
    2021.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（臨床実習）

  • 2018.04
    -
    2020.03

    慶應義塾大学, 大学院医学研究科, 助教（有期・研究奨励Ⅲ）

  • 2015.04
    -
    2018.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教

  • 2013.04
    -
    2015.03

    がん・感染症センター都立駒込病院, 歯科口腔外科, 非常勤医員(常勤的)

display all >>

Page Top ▲

Academic Background 【 Display / hide 】

  • 2003.04
    -
    2009.03

    The Nippon Dental University, Faculty of Dentistry

    University, Graduated

  • 2017.04
    -
    2021.03

    Keio University, Graduate School of Medicine, Keio University

    Graduate School, Completed, Doctoral course

Page Top ▲

Academic Degrees 【 Display / hide 】

  • Ph.D.in Medicine, Keio University, Coursework, 2021.03

    Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

Page Top ▲

Licenses and Qualifications 【 Display / hide 】

  • (公社)日本口腔外科学会認定口腔外科認定医, 2015.04

  • (公社)日本化学療法学会認定抗菌化学療法認定歯科医師, 2016.01

  • (公社)日本口腔外科学会認定口腔外科専門医, 2020.04

  • 日本がん治療認定医機構がん治療認定医 （歯科口腔外科）, 2021.04

  • ICD制度協議会認定ICD（Infection Control Doctor), 2022.01

display all >>

Page Top ▲
 

Research Areas 【 Display / hide 】

  • Life Science / Surgical dentistry

Page Top ▲

Research Keywords 【 Display / hide 】

  • 薬剤関連顎骨壊死

  • 骨代謝学

  • Patient-dervied xenografts

  • Oral cancer

  • Antibacterial Dental Device

display all >>

Page Top ▲
 

Books 【 Display / hide 】

Page Top ▲

Papers 【 Display / hide 】

  • Factors affecting the quality of life of patients with medication-related osteonecrosis of the jaw during treatment: A quality-of-life survey and causal analysis

    Kanako Munakata, Hidetaka Miyashita, Yuka Yamada, Tomoya Soma, Ryotaro Iwasaki, Taneaki Nakagawa, Seiji Asoda

    Journal of Cranio-Maxillofacial Surgery （Elsevier BV)   2024.03

    Accepted,  ISSN  1010-5182

    　View Summary

    This prospective cohort study aimed to investigate the impact of medication-related osteonecrosis of the jaw (MRONJ) on health-related quality of life (HRQOL) and oral health-related QOL (OHRQOL) and the association between the downstaging of MRONJ and OHRQOL. The HRQOL and OHRQOL of 44 patients with MRONJ were assessed using the SF-36v2 and the General Oral Health Assessment Index (GOHAI), respectively. Treatment was performed in accordance with the AAOMS position paper (2014). The SF-36v2 and GOHAI scores at the beginning of the survey were used to evaluate the impact of MRONJ on QOL. Potential confounders affecting the association between downstaging and QOL improvement were selected using directed acyclic graphs. Multiple regression analysis was performed to evaluate causal inferences. HRQOL scale scores declined below the national average. The three-component summary score (3CS), comprising the physical component summary (PCS), mental component summary (MCS), and role/social component summary (RCS), revealed that performance status and primary disease significantly affected the PCS and RCS (P = 0.005 and P < 0.001, respectively) and PCS and MCS (P = 0.024 and P = 0.003, respectively). The MRONJ stage did not influence the 3CS; however, OHRQOL declined in a stage-dependent manner (P = 0.005). Downstaging of MRONJ was independently associated with the improvement rate of the total GOHAI scores after adjusting for variables (P = 0.045). The HRQOL of patients with MRONJ declined; however, this may depend on the underlying disease status rather than the MRONJ stage. Improvement of the disease status can potentially predict an improvement in OHRQOL, regardless of the treatment modality.

  • Low energy availability reduces bone mass and gonadal function in male mice

    Eri Ito, Yuiko Sato, Tami Kobayashi, Tomoya Soma, Tatsuaki Matsumoto, Atushi Kimura, Kana Miyamoto, Hideo Matsumoto, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto

    Journal of Bone and Mineral Metabolism （Research Square Platform LLC)  41 （ 2 ） 182 - 192 2023.03

    Accepted,  ISSN  0914-8779

    　View Summary

    Abstract

    In women, the female athlete triad, marked by low energy availability, functional hypothalamic amenorrhea and osteoporosis, is a recognized risk for stress fractures. Stress injuries also occur in men, but by contrast risks and mechanisms underlying them are less characterized. Here we propose that low energy availability puts men at risk for stress injuries as well. Male low energy availability model mice, established by limiting food intake, exhibited significantly reduced testicle weight, serum testosterone levels and bone mass. Such losses in bone mass were enhanced by exercise in food-restricted (FR) male mice. Histological analysis revealed that both bone-resorbing and -forming activities were significantly reduced in FR or FR plus exercise (FR+ex) mice, mimicking a state of low bone turnover. Significantly reduced bone mass in FR or FR+ex male mice was significantly rescued by treatment with 1,25(OH)<sub>2</sub>D<sub>3</sub> (1.25) or ED71 (ED), both active vitamin D analogues, with significant restoration of osteoblastic activities. Serum levels of insulin-like growth factor I (IGF-I), which activates osteoblastic activities and is critical for bone remodeling, were significantly lower in FR versus control male mice, but restored by administration of either of vitamin D analogue. However, administration of recombinant IGF-I did not rescue reduced bone mass in FR male mice, and administration of either active vitamin D analogue could increase bone mass even in IGF-I conditional knockout FR male mice. Taken together, conditions comparable to the female athlete triad are also a risk for male stress injuries, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men.

  • FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes

    Okazaki Shogo, Yoshikawa Momoko, Soma Tomoya, Asoda Seiji, Imai Kenichi, Goitsuka Ryo, Saya Hideyuki, Nagano Osamu

    CANCER SCIENCE 114   1787 - 1787 2023.02

    ISSN  1347-9032

  • FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes

    Okazaki Shogo, Yoshikawa Momoko, Soma Tomoya, Asoda Seiji, Imai Kenichi, Goitsuka Ryo, Saya Hideyuki, Nagano Osamu

    CANCER SCIENCE 114   1917 - 1917 2023.02

    ISSN  1347-9032

  • A case of carcinoma ex pleomorphic adenoma in the minor salivary gland of the cheek

    Hidetaka Miyashita, Tomoya Soma, Terumi Takeuchi, Kanako Munakata, Yuka Yamada, Taneaki Nakagawa, Seiji Asoda

    Journal of Japanese Society of Oral Oncology （Japan Society for Oral Tumors)  35 （ 3 ） 115 - 121 2023

    Accepted,  ISSN  0915-5988

    　View Summary

    Carcinoma ex pleomorphic adenoma （Ca-ex-PA） mainly arises from the major salivary glands （i.e., parotid gland）, and adenocarcinoma not otherwise specified and salivary duct carcinoma are common histological types. Here, we report a case of a patient with Ca-ex-PA, with myoepithelial cancer derived from the minor salivary glands of the cheek. A 74-year-old woman was admitted to our hospital with swelling of her left cheek. MRI revealed a lobular mass lesion that surrounded the anterior margin of the left masseter muscle. A biopsy revealed the coexistence of malignant components with pleomorphic adenoma, which led to the diagnosis of Ca-ex-PA. Tumor resection and supraomohyoid neck dissection were performed, followed by anterolateral thigh flap transplantation. The patient had a good postoperative course, but about five months after the operation, died from another illness. As Ca-ex-PA is a rare disease in the minor salivary gland, it is desirable to establish preoperative diagnostic methods and treatment strategies by accumulating cases from multiple institutions.

display all >>

Page Top ▲

Reviews, Commentaries, etc. 【 Display / hide 】

  • 抗菌性を付与した有機/無機ハイブリットペースト状人工骨の作製とその特性評価

    加藤 史織, 宮下 英高, 鈴木 来, 相馬 智也, 中川 種昭, 森川 暁, 相澤 守

    日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   295 - 295 2022.11

  • 【GPの疑問に答える!歯科小手術の勘どころ】粘液嚢胞・エプーリスの除去を安全に行うには?

    相馬 智也

    DENTAL DIAMOND ((株)デンタルダイヤモンド社)  47 ( 3 ) 45 - 49 2022.02

    ISSN  0386-2305

  • Transcription factor FOXA1 is a negative regulator for xCT-dependent tumor formation in oral cancer

    Shogo Okazaki, Yuki Nakano, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Ryo Goitsuka, Hideyuki Saya, Osamu Nagano

    CANCER SCIENCE (WILEY)  113   1324 - 1324 2022.02

    ISSN  1347-9032

  • 口腔扁平上皮癌においてFOXA1発現はxCT依存的腫瘍成長を抑制する

    岡崎 章悟, 中野 友暉, 吉川 桃子, 相馬 智也, 莇生田 整治, 後飯塚 僚, 佐谷 秀行, 永野 修

    日本癌学会総会記事 ((一社)日本癌学会)  80回   [E11 - 2 2021.09

    ISSN  0546-0476

Page Top ▲

Presentations 【 Display / hide 】

  • 抗リン脂質抗体陽性患者に生じた壊死性軟部組織感染症の1例

    沼山浩明, 相馬智也, 臼田聡, 小高利絵, 宗像花楠子, 宮下英高, 中川種昭, 莇生田整治

    第33回日本有病者歯科医療学会総会・学術大会 (新潟市 新潟グランドホテル) , 

    2024.03
    , 

    Oral presentation (general)

  • Initiatives in the Skull Base Center at the Keio University Hospital

    Hidetaka Miyashita, Tomoya Soma, Yuka Yamada, Kanako Munakata, Taishi Kimura, Kaho Hiasa, Hiromasa Kawana, Taneaki Nakagawa, Seiji Asoda

    The 42st Annual Meeting of Japanese Society of Oral Oncology (北海道 北海道立道民活動センターかでる2.7) , 

    2024.01
    , 

    Oral presentation (general)

  • Development of anti-bacterial apatite-coated Ti implant loaded with basic fibroblast growth factor

    X.Y. Zhu, K. Suzuki, E. Onuma, S. Enjo, H. Miyashita, T. Soma, M. Nasu, T. Nakagawa, S. Morikawa, M. Aizawa

    The 21st Asian BioCeramics (ABC) Symposium (ABC2023) (富山県　富山国際会議場) , 

    2023.12

  • 自殺企図による舌切創の１例

    木村 大志, 臼田 聡, 小高 利絵, 山田 有佳, 宮下 英高, 相馬 智也, 宗像花楠子, 青木 孝仁, 中川 種昭, 莇生田整治

    第216回（公社）日本口腔外科学会関東支部学術集会 (東京都　AP東京八重洲) , 

    2023.12
    , 

    Oral presentation (general)

  • A case of dental implant reconstruction for maxillary sinus cancer

    MUNAKATA Kanako, USUDA Sho, SOMA Tomoya, YAMADA Yuka, MIYASHITA Hidetaka, HORIE Nobuyuki, ASODA Seiji, NAKAGAWA Taneaki

    The 27th Annual Meeting of Japanese Academy of MaxilloFacial Implants (東京都　国際医療福祉大学東京赤坂キャンパス) , 

    2023.12
    , 

    Oral presentation (general), (公社)日本顎顔面インプラント学会

display all >>

Page Top ▲

Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • ビタミンD誘導体による難治性骨破壊性疾患の治療への応用

    2023.04
    -
    2026.03

    日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Principal investigator

    　View Summary

    口腔顎顔面外科領域では口腔内疾患の多くに骨吸収や骨破壊などを伴う炎症性疾患が多く認められる。ビスフォスフォネート製剤などによる骨吸収製剤の副作用である薬剤関連顎骨壊死も炎症を伴う骨破壊性疾患のひとつである。申請者はこれまで、ビスフォスフォネート製剤を投与したマウスモデルを用い、炎症性サイトカインが、骨壊死の発生や破骨細胞を介した骨破壊を引き起こすことを明らかにした。近年、ビタミンDの抗炎症作用が注目されており、そこで本研究では、炎症を伴う難治性骨破壊性疾患に対するビタミンDの分子メカニズムを解明し、新たな治療方法の確立を目指したい。

  • C

    2022.04
    -
    2025.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

    　View Summary

    「口から食べること」による医学的効果は大きく、残存歯数が少ないほど、認知症の発症リスクが高くなるという負の関連を示す論文も公表され、健康寿命の延伸を果たすために、健全な口腔咀嚼機能の改善や構築は大きな課題であると考えられる。超高齢社会において「口から食べることを支援することによる健康寿命の延伸」に貢献するべく、安全な骨代謝機能と抗菌機能を兼ね備えた歯周組炎およびインプラント周囲炎骨再生材料を開発する。また、同様の抗菌システムを備えたインプラント周囲炎抵抗性デンタルインプラントシステムの開発を目指す。

  • C

    2022.04
    -
    2025.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

    　View Summary

    分化異常は悪性腫瘍において広く認められる特徴の一つであり、そのメカニズムの解明は新規治療法の開発につながることが期待される。しかし、その詳細は多くの悪性腫瘍において不明である。申請者は、ある種のセロトニン受容体が頭頸部扁平上皮癌などの扁平上皮癌（SCC）において高発現し、また、予後不良と相関すること、さらには、分化を抑制することにより、悪性腫瘍の進展に寄与することを見出した。本研究では、SCCにおけるHTR7の機能に着目し、その発現・活性制御メカニズムと詳細な分化制御機構の解明を試みる。さらにはセロトニンシグナルによる分化制御機構を標的とし、SCCに対する分化誘導療法の開発を目指す。

  • 炎症性サイトカイン制御による骨破壊性疾患における抗炎症性作用機序の解明

    2021.08
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up , Principal investigator

    　View Summary

    ビタミンDの生理的作用は、多岐にわたるが、われわれは、炎症性骨破壊疾患に注目した。口腔内は、細菌が常に存在する空間であり、急性・慢性疾患を問わず人間が、炎症性口腔内疾患に罹患する。骨吸収薬剤関連顎骨壊死を代表とする顎骨の骨破壊性疾患に罹患すると審美性、食事の摂取などを含めた機能性を損ない、QOLが著しく低下する。本研究により炎症性サイトカイン制御による新たな炎症性骨破壊疾患の治療法を見出す可能性が考えられる。

Page Top ▲

Awards 【 Display / hide 】

  • 第75回日本口腔科学会学術集会 Rising Scientist賞

    相馬智也, 森田麻友, 岩崎良太郎, 莇生田整治, 河奈裕正, 中川種昭, 宮本健史, 2021.05, ゾレドロネート投与と侵襲的歯科処置は，炎症性サイトカインを上昇させ，骨吸収薬剤関連顎骨壊死を誘発する

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 第5回日本骨免疫学会 優秀演題賞

    相馬智也, 森田麻友, 岩崎良太郎, 中川種昭, 宮本健史, 2019.06, 骨吸収抑制薬による薬剤関連顎骨壊死には炎症性サイトカインの上昇が必須である

    Type of Award： Award from Japanese society, conference, symposium, etc.

Page Top ▲
 

Memberships in Academic Societies 【 Display / hide 】

  • Asian Association of Oral and Maxillofacial Surgeons, 

    2018.01
    -
    Present

  • Japanese Society of Oral and Maxillofacial Surgeons, 

    2009.08
    -
    Present

  • Japanese Society of Pediatric Oral and Maxillofacial Surgery, 

    2022.09
    -
    Present

  • The Japanese Cancer Association, 

    2022.05
    -
    Present

  • The Japanese Society for Bone and Mineral Research, 

    2019.11
    -
    Present

display all >>

Page Top ▲