KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2024.10

  -

  Present

  Keio University School of Medicine, Department of Dentistry and Oral Surgery, Senior Assistant Professor

• 2025.04

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  Present

  慶應義塾大学病院, 歯科・口腔外科, 診療科医長（保険医長）

• 2021.04

  -

  2024.09

  慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（有期・医学部）

• 2018.04

  -

  2020.03

  慶應義塾大学, 大学院医学研究科, 助教（有期・研究奨励Ⅲ）

• 2015.04

  -

  2018.03

  慶應義塾大学医学部, 歯科・口腔外科学教室, 助教

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2017.04

  -

  2021.03

  Keio University, Graduate School of Medicine, Keio University

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Ph.D.in Medicine, Keio University, Coursework, 2021.03

  Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• （公社）日本口腔外科学会認定口腔外科指導医, 2024.04

• （公社）日本化学療法学会認定抗菌化学療法認定歯科医師, 2016.01

• （公社）日本口腔外科学会認定口腔外科専門医, 2020.04

• （一社）日本歯科専門医機構認定口腔外科専門医, 2020.04

• 日本がん治療認定医機構がん治療認定医 （歯科口腔外科）, 2021.04

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Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Surgical dentistry

• Life Science / Oral pathobiological science

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• 薬剤関連顎骨壊死

• 骨代謝学

• Patient-dervied xenografts

• Oral cancer

• Antibacterial Dental Device

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Books 【 Display / hide 】

Books 【 Display / hide 】

• デンタルダイヤモンド 2022年2月号【巻頭特集】GPの疑問に答える！ 歯科小手術の勘どころ

  相馬智也, デンタルダイヤモンド社, 2022.02

  Scope: 粘液嚢胞・エプーリスの除去を安全に行うには？

• よくわかる歯科小手術の基本―抜歯から歯周外科まで

  相馬智也, 莇生田整治, デンタルダイヤモンド社, 2016.10,  Page： 141

  Scope: 全身状態・疾患への配慮

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Maxillary impacted supernumerary tooth in a patient with in a patient with Osler-Weber-Rendu disease: A case report

  木村大志, 相馬智也, 莇生田整治, 遠藤友樹, 中川種昭, 内田育宏

  有病者歯科医療 ((一社)日本有病者歯科医療学会)  32 ( 5 ) 291 - 303 2024.09

  Accepted,  ISSN  0918-8150

  　View Summary

  オスラー病は皮膚や粘膜,全身臓器の血管異常をきたす常染色体優性遺伝疾患である.その診断にはCuracao criteriaと呼ばれる臨床診断が広く用いられている.今回われわれは,オスラー病を有する患者の上顎正中埋伏過剰歯の抜歯の1例を経験したためその概要を報告する.患者は8歳の男児,上顎正中埋伏過剰歯の精査・加療目的に当科を受診した.既往歴,家族歴から7歳時にオスラー病と診断されていた.上顎正中埋伏過剰歯は鼻腔底粘膜に接しており,反復性鼻出血の既往があることから入院・全身麻酔下に抜歯術を実施,術中・術後の異常出血は認められず経過は良好であった.本症例では術前からオスラー病と診断されていたが,既往歴や臨床所見,治療を契機として発見される可能性もあり,本疾患への理解を深める必要があると思われる.(著者抄録)

• Factors affecting the quality of life of patients with medication-related osteonecrosis of the jaw during treatment: A quality-of-life survey and causal analysis

  Kanako Munakata, Hidetaka Miyashita, Yuka Yamada, Tomoya Soma, Ryotaro Iwasaki, Taneaki Nakagawa, Seiji Asoda

  Journal of Cranio-Maxillofacial Surgery (Elsevier BV)  52 ( 6 ) 715 - 721 2024.03

  Accepted,  ISSN  1010-5182

  　View Summary

  This prospective cohort study aimed to investigate the impact of medication-related osteonecrosis of the jaw (MRONJ) on health-related quality of life (HRQOL) and oral health-related QOL (OHRQOL) and the association between the downstaging of MRONJ and OHRQOL. The HRQOL and OHRQOL of 44 patients with MRONJ were assessed using the SF-36v2 and the General Oral Health Assessment Index (GOHAI), respectively. Treatment was performed in accordance with the AAOMS position paper (2014). The SF-36v2 and GOHAI scores at the beginning of the survey were used to evaluate the impact of MRONJ on QOL. Potential confounders affecting the association between downstaging and QOL improvement were selected using directed acyclic graphs. Multiple regression analysis was performed to evaluate causal inferences. HRQOL scale scores declined below the national average. The three-component summary score (3CS), comprising the physical component summary (PCS), mental component summary (MCS), and role/social component summary (RCS), revealed that performance status and primary disease significantly affected the PCS and RCS (P = 0.005 and P < 0.001, respectively) and PCS and MCS (P = 0.024 and P = 0.003, respectively). The MRONJ stage did not influence the 3CS; however, OHRQOL declined in a stage-dependent manner (P = 0.005). Downstaging of MRONJ was independently associated with the improvement rate of the total GOHAI scores after adjusting for variables (P = 0.045). The HRQOL of patients with MRONJ declined; however, this may depend on the underlying disease status rather than the MRONJ stage. Improvement of the disease status can potentially predict an improvement in OHRQOL, regardless of the treatment modality.

  • Access to Document (DOI)

• Low energy availability reduces bone mass and gonadal function in male mice

  Eri Ito, Yuiko Sato, Tami Kobayashi, Tomoya Soma, Tatsuaki Matsumoto, Atushi Kimura, Kana Miyamoto, Hideo Matsumoto, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto

  Journal of Bone and Mineral Metabolism (Research Square Platform LLC)  41 ( 2 ) 182 - 192 2023.03

  Accepted,  ISSN  0914-8779

  　View Summary

  Abstract
  
  In women, the female athlete triad, marked by low energy availability, functional hypothalamic amenorrhea and osteoporosis, is a recognized risk for stress fractures. Stress injuries also occur in men, but by contrast risks and mechanisms underlying them are less characterized. Here we propose that low energy availability puts men at risk for stress injuries as well. Male low energy availability model mice, established by limiting food intake, exhibited significantly reduced testicle weight, serum testosterone levels and bone mass. Such losses in bone mass were enhanced by exercise in food-restricted (FR) male mice. Histological analysis revealed that both bone-resorbing and -forming activities were significantly reduced in FR or FR plus exercise (FR+ex) mice, mimicking a state of low bone turnover. Significantly reduced bone mass in FR or FR+ex male mice was significantly rescued by treatment with 1,25(OH)₂D₃ (1.25) or ED71 (ED), both active vitamin D analogues, with significant restoration of osteoblastic activities. Serum levels of insulin-like growth factor I (IGF-I), which activates osteoblastic activities and is critical for bone remodeling, were significantly lower in FR versus control male mice, but restored by administration of either of vitamin D analogue. However, administration of recombinant IGF-I did not rescue reduced bone mass in FR male mice, and administration of either active vitamin D analogue could increase bone mass even in IGF-I conditional knockout FR male mice. Taken together, conditions comparable to the female athlete triad are also a risk for male stress injuries, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men.

  • Access to Document (DOI)

• FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes

  Okazaki Shogo, Yoshikawa Momoko, Soma Tomoya, Asoda Seiji, Imai Kenichi, Goitsuka Ryo, Saya Hideyuki, Nagano Osamu

  CANCER SCIENCE 114   1787 - 1787 2023.02

  ISSN  1347-9032

• A case of carcinoma ex pleomorphic adenoma in the minor salivary gland of the cheek

  Hidetaka Miyashita, Tomoya Soma, Terumi Takeuchi, Kanako Munakata, Yuka Yamada, Taneaki Nakagawa, Seiji Asoda

  Journal of Japanese Society of Oral Oncology (Japan Society for Oral Tumors)  35 ( 3 ) 115 - 121 2023

  Accepted,  ISSN  0915-5988

  　View Summary

  Carcinoma ex pleomorphic adenoma （Ca-ex-PA） mainly arises from the major salivary glands （i.e., parotid gland）, and adenocarcinoma not otherwise specified and salivary duct carcinoma are common histological types. Here, we report a case of a patient with Ca-ex-PA, with myoepithelial cancer derived from the minor salivary glands of the cheek. A 74-year-old woman was admitted to our hospital with swelling of her left cheek. MRI revealed a lobular mass lesion that surrounded the anterior margin of the left masseter muscle. A biopsy revealed the coexistence of malignant components with pleomorphic adenoma, which led to the diagnosis of Ca-ex-PA. Tumor resection and supraomohyoid neck dissection were performed, followed by anterolateral thigh flap transplantation. The patient had a good postoperative course, but about five months after the operation, died from another illness. As Ca-ex-PA is a rare disease in the minor salivary gland, it is desirable to establish preoperative diagnostic methods and treatment strategies by accumulating cases from multiple institutions.

  • Access to Document (DOI)
  • CiNii Research

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• ゾレドロネートを投与されたマウスにおける抜歯処置は、炎症性サイトカインを上昇させ、顎骨壊死を誘発する

  Sōma, Tomoya

  (慶應義塾大学大学院医学研究科)  2020

• ゾレドロネートを投与されたマウスにおける抜歯処置は、炎症性サイトカインを上昇させ、顎骨壊死を誘発する

  Sōma, Tomoya

  (慶應義塾大学大学院医学研究科)  2020

• ゾレドロネートを投与されたマウスにおける抜歯処置は、炎症性サイトカインを上昇させ、顎骨壊死を誘発する

  Sōma, Tomoya

  (慶應義塾大学大学院医学研究科)  2020

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• う蝕治療に関連して生じた縦隔気腫の1例

  松島 領一郎, 相馬 智也, 臼田 頌, 遠藤 友樹, 安井 真梨子, 莇生田 整治, 中川 種昭

  日本口腔科学会雑誌 ((NPO)日本口腔科学会)  72 ( 4 ) 251 - 251 2023.12

  ISSN  0029-0297

• 抗菌性を付与した有機/無機ハイブリットペースト状人工骨の作製とその特性評価

  加藤 史織, 宮下 英高, 鈴木 来, 相馬 智也, 中川 種昭, 森川 暁, 相澤 守

  日本バイオマテリアル学会大会予稿集 (日本バイオマテリアル学会)  44回   295 - 295 2022.11

• 【GPの疑問に答える!歯科小手術の勘どころ】粘液嚢胞・エプーリスの除去を安全に行うには?

  相馬 智也

  DENTAL DIAMOND ((株)デンタルダイヤモンド社)  47 ( 3 ) 45 - 49 2022.02

  ISSN  0386-2305

• Transcription factor FOXA1 is a negative regulator for xCT-dependent tumor formation in oral cancer

  Shogo Okazaki, Yuki Nakano, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Ryo Goitsuka, Hideyuki Saya, Osamu Nagano

  CANCER SCIENCE (WILEY)  113   1324 - 1324 2022.02

  ISSN  1347-9032

• 口腔扁平上皮癌においてFOXA1発現はxCT依存的腫瘍成長を抑制する

  岡崎 章悟, 中野 友暉, 吉川 桃子, 相馬 智也, 莇生田 整治, 後飯塚 僚, 佐谷 秀行, 永野 修

  日本癌学会総会記事 ((一社)日本癌学会)  80回   [E11 - 2 2021.09

  ISSN  0546-0476

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Inhibition of anti-resorptive agent-related osteonecrosis of the Jaw in mice by controlling inflammatory cytokines

  Tomoya Soma, Fuka Honma, Mayu Morita, Ryotaro Iwasaki, Seiji Asoda, Taneaki Nakagawa

  26th International Conference on Oral and Maxillofacial Surgery (ICOMS 2025) (Marina Bay Sands Sands Expo & Convention Centre) , 

  2025.05

  , 

  Poster presentation

• Prospective cohort study of quality-of-life survey and causal analysis in the treatment of patient with medication-related osteonecrosis of the jaw

  Kanako Munakata, Hidetaka Miyashita, Yuka Yamada, Tomoya Soma, Ryotaro Iwasaki, Taneaki Nakagawa, Seiji Asoda

  26th International Conference on Oral and Maxillofacial Surgery (ICOMS 2025) (Marina Bay Sands Sands Expo & Convention Centre) , 

  2025.05

  , 

  Oral presentation (general)

• Pneumomediastinum due to dental treatment: A Clinical Study of 5 cases

  Taishi KIMURA, Tomoya SOMA, Shin KATO, Natsuki KOBAYASHI, Seiji ASODA, Kazuyuki TSUNODA, Taneaki NAKAGAWA

  The 79th Annual Meeting of Japanese Stomatological Society (長野県 キッセイ文化ホール・エア・ウォーターアリーナ松本) , 

  2025.05

  , 

  Oral presentation (general)

• 抜歯術前の精査を契機に確定診断されたEhlers-Danlos症候群の1例

  小野田魁人, 木村大志, 相馬智也, 志田真佑子, 日浅香保, 莇生田整治, 中川種昭

  第33回日本有病者歯科医療学会総会・学術大会 (東京都 御茶ノ水ソラシティカンファレンス) , 

  2025.03

  , 

  Oral presentation (general)

• Immobilization of silver ions on hydroxyapatite-coated titanium using inositol phosphate and its anti-bacterial property

  A. Kondo, X.Y. Zhu, K. Suzuki, H. Miyashita, T. Soma, M. Nasu, T. Nakagawa, S. Morikawa, M. Aizawa

  The Ceramic Society of Japan Annual Meeting 2025 (静岡県 静岡大学浜松キャンパス) , 

  2025.03

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 力学的負荷を加えた多重障害インプラント周囲炎モデルの構築

  2024.10

  -

  Present

  公益社団法人日本顎顔面インプラント学会 , 第3回赤坂庸子若手研究奨励基金, Coinvestigator(s)

• ビタミンD誘導体による難治性骨破壊性疾患の治療への応用

  2023.04

  -

  2026.03

  日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Principal investigator

  　View Summary

  口腔顎顔面外科領域では口腔内疾患の多くに骨吸収や骨破壊などを伴う炎症性疾患が多く認められる。ビスフォスフォネート製剤などによる骨吸収製剤の副作用である薬剤関連顎骨壊死も炎症を伴う骨破壊性疾患のひとつである。申請者はこれまで、ビスフォスフォネート製剤を投与したマウスモデルを用い、炎症性サイトカインが、骨壊死の発生や破骨細胞を介した骨破壊を引き起こすことを明らかにした。近年、ビタミンDの抗炎症作用が注目されており、そこで本研究では、炎症を伴う難治性骨破壊性疾患に対するビタミンDの分子メカニズムを解明し、新たな治療方法の確立を目指したい。

• C

  2022.04

  -

  2025.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

  　View Summary

  分化異常は悪性腫瘍において広く認められる特徴の一つであり、そのメカニズムの解明は新規治療法の開発につながることが期待される。しかし、その詳細は多くの悪性腫瘍において不明である。申請者は、ある種のセロトニン受容体が頭頸部扁平上皮癌などの扁平上皮癌（SCC）において高発現し、また、予後不良と相関すること、さらには、分化を抑制することにより、悪性腫瘍の進展に寄与することを見出した。本研究では、SCCにおけるHTR7の機能に着目し、その発現・活性制御メカニズムと詳細な分化制御機構の解明を試みる。さらにはセロトニンシグナルによる分化制御機構を標的とし、SCCに対する分化誘導療法の開発を目指す。

• C

  2022.04

  -

  2025.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

  　View Summary

  「口から食べること」による医学的効果は大きく、残存歯数が少ないほど、認知症の発症リスクが高くなるという負の関連を示す論文も公表され、健康寿命の延伸を果たすために、健全な口腔咀嚼機能の改善や構築は大きな課題であると考えられる。超高齢社会において「口から食べることを支援することによる健康寿命の延伸」に貢献するべく、安全な骨代謝機能と抗菌機能を兼ね備えた歯周組炎およびインプラント周囲炎骨再生材料を開発する。また、同様の抗菌システムを備えたインプラント周囲炎抵抗性デンタルインプラントシステムの開発を目指す。

• Anti-inflammatory mechanisms of action in bone-destroying diseases through inflammatory cytokine regulation

  2021.08

  -

  2023.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Soma Tomoya, Grant-in-Aid for Research Activity Start-up , Principal investigator

  　View Summary

  Many animal models of MRONJ have been reported, but most of these studies have focused on the content of the drugs administered. The fact that osteonecrosis develops only in limited areas despite systemic administration of anti-resorptive agent led us to hypothesize that infection by oral bacteria contributes to the development of osteonecrosis. We analyzed how osteonecrosis is caused by the administration of ARA and oral bacteria. Using a model, the applicants have shown that inflammatory cytokines induce osteonecrosis and osteoclast-mediated bone destruction.
  In this study, we created a model of MRONJ of mice and confirmed that administration of certain drugs suppressed osteonecrosis, suggesting that administration of drugs may suppress inflammatory cytokines in mouse serum, thereby acting systemically to suppress osteonecrosis. The results of this study suggest that the administration of drugs may inhibit osteonecrosis by suppressing inflammatory cytokines in the serum of mice.

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• JBMM Excellent Paper Award

  Tomoya Soma, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Satoshi Nakamura, Yosuke Kaneko, Eri Ito, Hiroyuki Okada, Hisato Watanabe, Kana Miyamoto, Morio Matsumoto, Masaya Nakamura, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Takeshi Miyamoto, 2024.07, The Japanese Society for Bone and Mineral Research, Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

  Type of Award： Award from Japanese society, conference, symposium, etc.

• Biomaterials International 2023 Best Poster Paper Award

  X.Y. Zhu, K. Suzuki, E. Onuma, S. Enjo, H. Miyashita, T. Soma, M.Nasu,T. Nakagawa, S. Morikawa, M. Aizawa, 2023.08, Biomaterials International 2023, Loading of basic fibroblast growth factor on apatite-coated titanium with anti-bacterial property and its material properties

  Type of Award： Award from international society, conference, symposium, etc.

• 第75回日本口腔科学会学術集会 Rising Scientist賞

  相馬智也, 森田麻友, 岩崎良太郎, 莇生田整治, 河奈裕正, 中川種昭, 宮本健史, 2021.05, ゾレドロネート投与と侵襲的歯科処置は，炎症性サイトカインを上昇させ，骨吸収薬剤関連顎骨壊死を誘発する

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 第74回NPO法人日本口腔科学会web学会賞

  黄地 健仁;森川 暁;高橋 萌;吉川 桃子;相馬 智也;宮下 英高;河奈 裕正;中川 種昭;莇生田 整治, 2020.07, 紡錘細胞癌における間葉系幹細胞の同定とPDGFRα阻害薬を用いた細胞死の誘導

• 第5回日本骨免疫学会 優秀演題賞

  相馬智也, 森田麻友, 岩崎良太郎, 中川種昭, 宮本健史, 2019.06, 骨吸収抑制薬による薬剤関連顎骨壊死には炎症性サイトカインの上昇が必須である

  Type of Award： Award from Japanese society, conference, symposium, etc.

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• Asian Association of Oral and Maxillofacial Surgeons, 

  2018.01

  -

  Present

• Japanese Society of Oral and Maxillofacial Surgeons, 

  2009.08

  -

  Present

• Japanese Society of Pediatric Oral and Maxillofacial Surgery, 

  2022.09

  -

  Present

• The Japanese Cancer Association, 

  2022.05

  -

  Present

• The Japanese Society for Bone and Mineral Research, 

  2019.11

  -

  Present

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