Soma, Tomoya

写真a

Affiliation

School of Medicine, Department of Dentistry and Oral Surgery （Shinanomachi）

Position

Instructor
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Career 【 Display / hide 】

  • 2021.04
    -
    Present

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（有期・医学部）

  • 2020.04
    -
    2021.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（臨床実習）

  • 2018.04
    -
    2020.03

    慶應義塾大学, 大学院医学研究科, 助教（有期・研究奨励Ⅲ）

  • 2015.04
    -
    2018.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教

  • 2013.04
    -
    2015.03

    がん・感染症センター都立駒込病院, 歯科口腔外科, 非常勤医員(常勤的)

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Academic Background 【 Display / hide 】

  • 2003.04
    -
    2009.03

    The Nippon Dental University, Faculty of Dentistry

    University, Graduated

  • 2017.04
    -
    2021.03

    Keio University, 大学院医学研究科

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Ph.D.in Medicine, Keio University, Coursework, 2021.03

    Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

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Licenses and Qualifications 【 Display / hide 】

  • (公社)日本口腔外科学会認定口腔外科認定医, 2015.04

  • (公社)日本化学療法学会認定抗菌化学療法認定歯科医師, 2016.01

  • (公社)日本口腔外科学会認定口腔外科専門医, 2020.04

  • 日本がん治療認定医機構がん治療認定医 （歯科口腔外科）, 2021.04

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Research Areas 【 Display / hide 】

  • Surgical dentistry

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Research Keywords 【 Display / hide 】

  • 薬剤関連顎骨壊死

  • 骨代謝学

  • 口腔がん

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Books 【 Display / hide 】

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Papers 【 Display / hide 】

  • Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring

    Eri Ito, Yuiko Sato, Tami Kobayashi, Tomoya Soma, Tatsuaki Matsumoto, Atsushi Kimura, Kana Miyamoto, Hideo Matsumoto, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto

    Bone （Elsevier BV)  153   116133 - 116133 2021.12

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  8756-3282

    　View Summary

    Changes in bone metabolism occur in mothers during pregnancy or lactation that may decrease bone mass and result in fragility fractures after partum. However, use of drugs during pregnancy or lactation to counteract these effects is often prohibited or strongly discouraged. Therefore, approaches to protect mothers from fragility fractures have not been established. Here we show that bone mineral density was significantly lower in female mice after partum than in age-matched female mice without partum. We also show that temporary administration of the bisphosphonate alendronate, either just before or just after pregnancy, to female mice was protective against bone loss due to pregnancy or lactation and had no adverse effects on offspring, such as growth retardation. Furthermore, we show that alendronate administration to female mice during lactation was effective in increasing bone mass in mothers without promoting bone abnormalities or growth retardation in offspring. Calcium levels in milk from female mice administered alendronate during lactation were equivalent to those in milk from mothers not treated with alendronate. Overall, we propose that alendronate administration to mothers could prevent bone loss and fragility fractures during pregnancy and lactation.

  • Clinical value of entire-circumferential intraoperative frozen section analysis for the complete resection of superficial squamous cell carcinoma of the tongue.

    Asoda S, Miyashita H, Soma T, Munakata K, Yamada Y, Yasui Y, Kudo Y, Usuda S, Hasegawa T, Nakagawa T, Kawana H

    Oral oncology （Elsevier BV)  123   105629 - 105629 2021.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1368-8375

    　View Summary

    Objectives: We aimed to evaluate the clinical value of an entire-circumferential intraoperative frozen section analysis (e-IFSA) for the complete resection of superficial squamous cell carcinoma (SCC) of the tongue. Materials and Methods: A total 276 specimens from 51 patients with pT1-2, N0, mucosal or submucosal invasion SCC were analyzed to evaluate the diagnostic accuracy of the e-IFSA and the added value of the e-IFSA to iodine staining. The e-IFSA results were compared with the final histologic results obtained using permanent sections. All specimens for the e-IFSA were taken over the entire circumference 5 mm outside from the iodine unstained areas. The outline of the main resected specimen after taking these outer mucosal specimens were defined as the surgical margins determined by iodine staining alone. Results: The e-IFSA results were in excellent agreement with final histological results (Cohen's kappa value: 0.85) and the e-IFSA showed high sensitivity (100%) and high negative predictive value (100%). The actual complete resection rate with an e-IFSA was 100% (51/51), and no patient required additional resection after surgery. In contrast, 10/51 patients (20%) patients showed residual atypical mucosal epithelium at or beyond the margin determined by iodine staining alone; this difference was statistically significant (P = 0.002). The 5-year local control rate and 5-year overall survival rate after this procedure were both 100%. Conclusion: An e-IFSA has additional value when performed in conjunction with iodine staining. An e-IFSA would be useful for achieving complete resection of superficial SCC of the tongue.

  • Adipose-Derived Stem Cell Sheets Improve Early Biomechanical Graft Strength in Rabbits After Anterior Cruciate Ligament Reconstruction.

    Matsumoto T, Sato Y, Kobayashi T, Suzuki K, Kimura A, Soma T, Ito E, Kikuchi T, Kobayashi S, Harato K, Niki Y, Matsumoto M, Nakamura M, Miyamoto T

    The American journal of sports medicine （American Journal of Sports Medicine)  49 （ 13 ） 3635465211041582 - 3635465211041582 2021.10

    Research paper (scientific journal), Joint Work, Except for reviews,  ISSN  0363-5465

    　View Summary

    BACKGROUND: Although various reconstruction techniques are available for anterior cruciate ligament (ACL) injuries, a long recovery time is required before patients return to sports activities, as the reconstructed ACL requires time to regain strength. To date, several studies have reported use of mesenchymal stem cells in orthopaedic surgery; however, no studies have used adipose-derived stem cell (ADSC) sheets in ACL reconstruction (ACLR). HYPOTHESIS: ADSC sheet transplantation can improve biomechanical strength of the autograft used in ACLR. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 68 healthy Japanese white rabbits underwent unilateral ACLR with a semitendinosus tendon autograft after random enrollment into a control group (no sheet; n = 34) and a sheet group (ADSC sheet; n = 34). At 2, 4, 8, 16, and 24 weeks after surgery, rabbits in each group were sacrificed to evaluate tendon-bone healing using histological staining, micro-computed tomography, and biomechanical testing. At 24 weeks, scanning transmission electron microscopy of the graft midsubstance was performed. RESULTS: The ultimate failure load for the control and sheet groups, respectively, was as follows: 17.2 ± 5.5 versus 37.3 ± 10.3 (P = .01) at 2 weeks, 28.6 ± 1.9 versus 47.4 ± 10.4 (P = .003) at 4 weeks, 53.0 ± 14.3 versus 48.1 ± 9.3 (P = .59) at 8 weeks, 66.2 ± 9.3 versus 95.2 ± 43.1 (P = .24) at 16 weeks, and 66.7 ± 27.3 versus 85.3 ± 29.5 (P = .39) at 24 weeks. The histological score was also significantly higher in the sheet group compared with the control group at early stages up to 8 weeks. On micro-computed tomography, relative to the control group, the bone tunnel area was significantly narrower in the sheet group at 4 weeks, and the bone volume/tissue volume of the tendon-bone interface was significantly greater at 24 weeks. Scanning transmission electron microscopy at 24 weeks indicated that the mean collagen fiber diameter in the midsubstance was significantly greater, as was the occupation ratio of collagen fibers per field of view, in the sheet group. CONCLUSION: ADSC sheets improved biomechanical strength, prevented bone tunnel enlargement, and promoted tendon-bone interface healing and graft midsubstance healing in an in vivo rabbit model. CLINICAL RELEVANCE: ADSC sheets may be useful for early tendon-bone healing and graft maturation in ACLR.

  • Undifferentiated carcinoma of the mandible detected simultaneously with the liver: A case report

    Seiji Asoda, Mayu Morita, Tomoya Soma, Hitoshi Sato, Toshihiro Hasegawa, Taneaki Nakagawa, Akinori Hashiguchi, Hiromasa Kawana

    Oral and Maxillofacial Surgery Cases （Elsevier BV)  7 （ 3 ） 100228 - 100228 2021.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  2214-5419

    　View Summary

    We herein report a rare case of undifferentiated carcinoma that originated in the mandible with the same pathological findings as seen in the liver. A 64-year-old man underwent surgery for a hepatic tumor in October 2006, and the pathological diagnosis was undifferentiated carcinoma. The patient was referred to our department in January 2007, when whole-body positron emission tomography/computed tomography showed the uptake of fluorodeoxyglucose in the right mandibular ramus. The patient underwent right hemimandibulectomy in April 2007. The resected tumor was also undifferentiated carcinoma. In May 2014, seven years after the lower mandibular operation, the tumor recurred at the site corresponding to the right mandibular ramus after resection, and tumor resection and right neck dissection were performed. As a result of the histopathological examination, the undifferentiated carcinoma findings were the same as before. There have been no signs of local recurrence or metastases for over six years since the second mandibular surgery.

  • Synoviolin is not a pathogenic factor for auto-inflammatory diseases.

    Matsumoto T, Sato Y, Kobayashi T, Ito E, Soma T, Kimura A, Miyamoto K, Kobayashi S, Harato K, Matsumoto M, Nakamura M, Niki Y, Miyamoto T

    Biochemical and biophysical research communications （Elsevier BV)  558   183 - 188 2021.04

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0006-291X

    　View Summary

    Auto-inflammatory syndromes are rare diseases characterized by arthritis and joint destruction, symptoms similar to but distinct from rheumatoid arthritis (RA). Therapeutic targets have not been well characterized for auto-inflammatory syndromes, although the E3 ligase Synoviolin was previously shown to be a novel therapeutic target for RA. Here, we show that Synoviolin loss has little impact on a model of auto-inflammatory diseases. We previously established such a model, the hIL-1 cTg mouse, in which IL-1 signaling was constitutively activated, and animals exhibit symptoms recapitulating auto-inflammatory syndromes such as major joint dominant arthritis. Here, we crossed hIL-1 cTg with Synoviolin flox'd mice to yield hIL-1 cTg/Synoviolin cKO mice. Synoviolin gene expression was ablated in adult hIL-1 cTg/Synoviolin cKO mice by injection of pIpC to activate Mx1 promoter-driven Cre recombinase. However, symptoms seen in hIL-1 cTg mice such as arthritis and joint destruction were not alleviated by targeting Synoviolin, ruling out Synoviolin as a therapeutic target for auto-inflammatory disease. Our results indicate that although similar, RA and auto-inflammatory diseases are different diseases, and treatment strategies should differ accordingly.

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Presentations 【 Display / hide 】

  • Verification of the inhibitory effect of inflammatory cytokine regulation in an anti-resorptive agent-related osteonecrosis of the Jaw model

    相馬智也, 森田麻友, 岩崎良太, 莇生田整, 川種昭, 宮本健史

    Verification of the inhibitory effect of inflammatory cytokine regulation in an anti-resorptive agent-related osteonecrosis of the Jaw model, 2021.10, Oral Presentation(general)

  • 炎症性サイトカインの制御による骨吸収抑制薬関連顎骨壊死抑制効果の検証

    相馬 智也, 森田 麻友, 岩崎 良太郎, 莇生田 整治, 河奈 裕正, 中川 種昭, 宮本 健史

    第6回日本骨免疫学会, 2021.06, Other

  • 再発・転移口腔癌における ゲノム医療導入の１例

    金生茉莉, 相馬智也, 宮下英高, 宗像花楠子, 山田有佳, 中川種昭, 莇生田整治

    第211回（公社）日本口腔外科学会関東支部学術集会, 2021.05, Other

  • Invasive dental treatment administered zoledronate increases inflammatory cytokine levels and promotes anti-resorptive agents-related osteonecrosis of the jaw

    相馬智也, 森田麻友, 岩崎良太郎, 莇生田整治, 河奈裕正, 中川種昭, 宮本健史

    Invasive dental treatment administered zoledronate increases inflammatory cytokine levels and promotes anti-resorptive agents-related osteonecrosis of the jaw, 2021.05, Poster (general), (NPO)日本口腔科学会

  • Advanced tongue cancer that responded well to combination therapy with cetuximab: A case report

    日浅香保, 宮下英高, 相馬智也, 宗像花楠子, 山田有佳, 木村萌美, 中川種昭, 莇生田整治

    The 39th Annual Meeting of Japanese Society of Oral Oncology, 2021.01, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 炎症性サイトカイン制御による骨破壊性疾患における抗炎症性作用機序の解明

    2021.08
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 相馬 智也, Grant-in-Aid for Research Activity Start-up , Principal Investigator

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Awards 【 Display / hide 】

  • 第75回日本口腔科学会学術集会 Rising Scientist賞

    相馬智也, 2021.05, ゾレドロネート投与と侵襲的歯科処置は，炎症性サイトカインを上昇させ，骨吸収薬剤関連顎骨壊死を誘発する

    Type of Award： Awards of National Conference, Council and Symposium

  • 第5回日本骨免疫学会 優秀演題賞

    Tomoya Soma, 2019.06, 骨吸収抑制薬による薬剤関連顎骨壊死には炎症性サイトカインの上昇が必須である

    Type of Award： Awards of National Conference, Council and Symposium

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Memberships in Academic Societies 【 Display / hide 】

  • Japanese Society of Oral and Maxillofacial Surgeons

    　

  • Japanese Society of Oral Oncology

    　

  • Japanese Society of Chemotherapy

    　

  • Japanese Society of Oral Therapeutics and Pharmacology

    　

  • Japanese Academy of Maxillofacial Implants

    　

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