SOMA Tomoya

写真a

Affiliation

School of Medicine, Department of Dentistry and Oral Surgery （Shinanomachi）

Position

Instructor

External Links
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Career 【 Display / hide 】

  • 2021.04
    -
    Present

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（有期・医学部）

  • 2020.04
    -
    2021.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（臨床実習）

  • 2018.04
    -
    2020.03

    慶應義塾大学, 大学院医学研究科, 助教（有期・研究奨励Ⅲ）

  • 2015.04
    -
    2018.03

    慶應義塾大学医学部, 歯科・口腔外科学教室, 助教

  • 2013.04
    -
    2015.03

    がん・感染症センター都立駒込病院, 歯科口腔外科, 非常勤医員(常勤的)

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Academic Background 【 Display / hide 】

  • 2003.04
    -
    2009.03

    The Nippon Dental University, Faculty of Dentistry

    University, Graduated

  • 2017.04
    -
    2021.03

    Keio University, Graduate School of Medicine, Keio University

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Ph.D.in Medicine, Keio University, Coursework, 2021.03

    Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

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Licenses and Qualifications 【 Display / hide 】

  • (公社)日本口腔外科学会認定口腔外科認定医, 2015.04

  • (公社)日本化学療法学会認定抗菌化学療法認定歯科医師, 2016.01

  • (公社)日本口腔外科学会認定口腔外科専門医, 2020.04

  • 日本がん治療認定医機構がん治療認定医 （歯科口腔外科）, 2021.04

  • ICD制度協議会認定ICD（Infection Control Doctor), 2022.01

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Research Areas 【 Display / hide 】

  • Life Science / Surgical dentistry

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Research Keywords 【 Display / hide 】

  • 薬剤関連顎骨壊死

  • 骨代謝学

  • Patient-dervied xenografts

  • Oral cancer

  • Head and Neck Cancer

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Books 【 Display / hide 】

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Papers 【 Display / hide 】

  • Low energy availability reduces bone mass and gonadal function in male mice

    Eri Ito, Yuiko Sato, Tami Kobayashi, Tomoya Soma, Tatsuaki Matsumoto, Atushi Kimura, Kana Miyamoto, Hideo Matsumoto, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto

    Journal of Bone and Mineral Metabolism （Research Square Platform LLC)  41 （ 2 ） 182 - 192 2023.03

    Accepted,  ISSN  0914-8779

    　View Summary

    Abstract

    In women, the female athlete triad, marked by low energy availability, functional hypothalamic amenorrhea and osteoporosis, is a recognized risk for stress fractures. Stress injuries also occur in men, but by contrast risks and mechanisms underlying them are less characterized. Here we propose that low energy availability puts men at risk for stress injuries as well. Male low energy availability model mice, established by limiting food intake, exhibited significantly reduced testicle weight, serum testosterone levels and bone mass. Such losses in bone mass were enhanced by exercise in food-restricted (FR) male mice. Histological analysis revealed that both bone-resorbing and -forming activities were significantly reduced in FR or FR plus exercise (FR+ex) mice, mimicking a state of low bone turnover. Significantly reduced bone mass in FR or FR+ex male mice was significantly rescued by treatment with 1,25(OH)<sub>2</sub>D<sub>3</sub> (1.25) or ED71 (ED), both active vitamin D analogues, with significant restoration of osteoblastic activities. Serum levels of insulin-like growth factor I (IGF-I), which activates osteoblastic activities and is critical for bone remodeling, were significantly lower in FR versus control male mice, but restored by administration of either of vitamin D analogue. However, administration of recombinant IGF-I did not rescue reduced bone mass in FR male mice, and administration of either active vitamin D analogue could increase bone mass even in IGF-I conditional knockout FR male mice. Taken together, conditions comparable to the female athlete triad are also a risk for male stress injuries, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men.

  • An ionic silver coating prevents implant-associated infection by anaerobic bacteria in vitro and in vivo in mice

    Tomoya Soma, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Eri Ito, Tatsuaki Matsumoto, Atsushi Kimura, Fuka Homma, Keitarou Saiki, Yukihiro Takahashi, Kana Miyamoto, Morio Matsumoto, Masaya Nakamura, Mayu Morita, Ken Ishii, Seiji Asoda, Hiromasa Kawana, Zhu Xingyu, Mamoru Aizawa, Taneaki Nakagawa, Takeshi Miyamoto

    Scientific Reports （Springer Science and Business Media LLC)  12 （ 1 ） 18387 - 18387 2022.11

    Lead author, Accepted,  ISSN  2045-2322

    　View Summary

    Abstract

    Currently, implants are utilized clinically for bone transplant procedures. However, if infectious osteomyelitis occurs at implant sites, removal of bacteria can be challenging. Moreover, altered blood flow at peri-implant infectious sites can create an anaerobic environment, making it more difficult to treat infection with antibiotics. Thus, it would be beneficial if implants could be modified to exhibit antibacterial activity, even in anaerobic conditions. Here, we show antibacterial activity of silver ions coated on titanium rods, even against the anaerobic bacteria Porphyromonas gingivalis (P. gingivalis), both in vitro and in vivo. Specifically, we implanted silver-coated or control uncoated titanium rods along with P. gingivalis in mouse femoral bone BM cavities and observed significantly inhibited P. gingivalis infection with silver-coated compared with non-coated rods, based on in vivo bio-imaging. Osteonecrosis by infectious osteomyelitis and elevation of the inflammatory factors C-reactive protein and IL-6 promoted by P. gingivalis s were also significantly reduced in the presence of silver-coated rods. Overall, our study indicates that silver ion coating of an implant represents a therapeutic option to prevent associated infection, even in anaerobic conditions or against anaerobic bacteria.

  • Evaluation of the surgical approach based on impacted position and direction of mesiodens

    Moemi Kimura, Takazumi Yasui, Seiji Asoda, Hiroki Nagamine, Tomoya Soma, Takeshi Karube, Rie Kodaka, Wataru Muraoka, Taneaki Nakagawa, Katsuhiro Onizawa

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology （Elsevier BV)  35 （ 1 ） 23 - 29 2022.08

    Accepted,  ISSN  2212-5558

    　View Summary

    Objective: This study aimed to reveal the relationship between the approach of extraction and the position of the mesiodens by systematic classification. Methods: This retrospective study included patients with impacted mesiodens that required computed tomography for extraction. The direction, sagittal and axial position, eruption from the nasal floor, surrounding bone thickness, surgical approach, and anesthesia type for the impacted mesiodens were analyzed. Mesiodens were classified into three groups (V: vertical position, H: horizontal position, and D: direction), and each group was classified into three subgroups (V1, 2, 3; H1, 2, 3; D1, 2, 3). Results: A total of 169 impacted mesiodens were included in this study. The palatal approach was the most common (151 teeth, 89.3%), followed by the labial approach (11 teeth, 6.5%) and nasal floor approach (6 teeth, 3.6%). The bone thickness from the mesiodens to the palatal surface were significantly shorter in palatal far region of nasopalatine duct (H3) than in palatal near region (H2) (P < 0.05). In vertical high position (V3), the percentage of the palatal approach in H3 (87.5%) was higher than that in H2 (71.4%). Additionally, 15 teeth erupting from the nasal floor wherein four were extracted by the nasal floor approach in H2 but only one tooth in H3. Conclusions: Even at higher positions, mesiodens located in the palatal far region tended to be extracted by the palatal approach because of the thin bone thickness.

  • Transcription factor FOXA1 is a negative regulator for xCT-dependent tumor formation in oral cancer

    Okazaki Shogo, Nakano Yuki, Yoshikawa Momoko, Soma Tomoya, Asoda Seiji, Goitsuka Ryo, Saya Hideyuki, Nagano Osamu

    CANCER SCIENCE 113   1324 - 1324 2022.02

    ISSN  1347-9032

  • Hao1 Is Not a Pathogenic Factor for Ectopic Ossifications but Functions to Regulate the TCA Cycle In Vivo

    Atsushi Kimura, Akiyoshi Hirayama, Tatsuaki Matsumoto, Yuiko Sato, Tami Kobayashi, Satsuki Ikeda, Midori Maruyama, Mari Kaneko, Mayo Shigeta, Eri Ito, Tomoya Soma, Kana Miyamoto, Tomoyoshi Soga, Masaru Tomita, Akihito Oya, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto

    Metabolites （MDPI AG)  12 （ 1 ） 82 - 82 2022.01

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  2218-1989

    　View Summary

    Ossification of the posterior longitudinal ligament (OPLL), a disease characterized by the ectopic ossification of a spinal ligament, promotes neurological disorders associated with spinal canal stenosis. While blocking ectopic ossification is mandatory to prevent OPLL development and progression, the mechanisms underlying the condition remain unknown. Here we show that expression of hydroxyacid oxidase 1 (Hao1), a gene identified in a previous genome-wide association study (GWAS) as an OPLL-associated candidate gene, specifically and significantly decreased in fibroblasts during osteoblast differentiation. We then newly established Hao1-deficient mice by generating Hao1-flox mice and crossing them with CAG-Cre mice to yield global Hao1-knockout (CAG-Cre/Hao1flox/flox; Hao1 KO) animals. Hao1 KO mice were born normally and exhibited no obvious phenotypes, including growth retardation. Moreover, Hao1 KO mice did not exhibit ectopic ossification or calcification. However, urinary levels of some metabolites of the tricarboxylic acid (TCA) cycle were significantly lower in Hao1 KO compared to control mice based on comprehensive metabolomic analysis. Our data indicate that Hao1 loss does not promote ectopic ossification, but rather that Hao1 functions to regulate the TCA cycle in vivo.

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 【GPの疑問に答える!歯科小手術の勘どころ】粘液嚢胞・エプーリスの除去を安全に行うには?

    相馬 智也

    DENTAL DIAMOND ((株)デンタルダイヤモンド社)  47 ( 3 ) 45 - 49 2022.02

    ISSN  0386-2305

  • Transcription factor FOXA1 is a negative regulator for xCT-dependent tumor formation in oral cancer

    Shogo Okazaki, Yuki Nakano, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Ryo Goitsuka, Hideyuki Saya, Osamu Nagano

    CANCER SCIENCE (WILEY)  113   1324 - 1324 2022.02

    ISSN  1347-9032

  • 口腔扁平上皮癌においてFOXA1発現はxCT依存的腫瘍成長を抑制する

    岡崎 章悟, 中野 友暉, 吉川 桃子, 相馬 智也, 莇生田 整治, 後飯塚 僚, 佐谷 秀行, 永野 修

    日本癌学会総会記事 ((一社)日本癌学会)  80回   [E11 - 2 2021.09

    ISSN  0546-0476

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Presentations 【 Display / hide 】

  • Fabrications of Anti-bacterial Paste-like Artificial Bones using Calcium Carbonate Loaded with Silver Nanoparticles and Their Materials Properties

    Y. Kamaya, S. Kato, H. Miyashita, T. Soma, T. Nakagawa, A. Morikawa, M. Aizawa

    公益社団法人日本セラミックス協会2023年年会, 

    2023.03

  • A case of peripheral ameloblastic fibro-odontoma in the gingiva

    Takahito Aoki, Hidetaka Miyashita, Akihisa Ueno, Yohei Masugi, Kanako Munakata, Tomoya Soma, Taneaki Nakagawa, Seiji Asoda

    The 41st Annual Meeting of Japanese Society of Oral Oncology, 

    2023.01
    -
    2023.02
    , 

    Poster presentation

  • オスラー病を有する患者の上顎正中埋伏過剰歯の1 例

    木村大志, 相馬智也, 莇生田整治, 遠藤友樹, 中川種昭, 内田育宏

    第214回（公社）日本口腔外科学会関東支部学術集会, 

    2022.12
    , 

    Oral presentation (general)

  • 骨髄異形成/骨髄増殖性腫瘍患者に生じた頸部壊死性筋膜炎の1例

    下濱啓, 宮下英高, 相馬智也, 宗像花楠子, 木村大志, 内田育宏, 中川種昭, 莇生田整治

    第214回（公社）日本口腔外科学会関東地方会, 

    2022.12
    , 

    Oral presentation (general)

  • Decreased expression of FOXA1 promotes tumor growth and xCT dependency in oral squamous cell carcinoma

    岡﨑章悟, 中島由梨佳, 吉川桃子, 相馬智也, 莇生田整治, 今井健一, 後飯塚僚, 佐谷秀行, 永野修

    The 45th Annual Mreeeting of the Molecular Biology Society of Japan, 

    2022.11
    -
    2022.12
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • ビタミンD誘導体による難治性骨破壊性疾患の治療への応用

    2023.04
    -
    2026.03

    日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Principal investigator

  • C

    2022.04
    -
    2025.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

    　View Summary

    「口から食べること」による医学的効果は大きく、残存歯数が少ないほど、認知症の発症リスクが高くなるという負の関連を示す論文も公表され、健康寿命の延伸を果たすために、健全な口腔咀嚼機能の改善や構築は大きな課題であると考えられる。超高齢社会において「口から食べることを支援することによる健康寿命の延伸」に貢献するべく、安全な骨代謝機能と抗菌機能を兼ね備えた歯周組炎およびインプラント周囲炎骨再生材料を開発する。また、同様の抗菌システムを備えたインプラント周囲炎抵抗性デンタルインプラントシステムの開発を目指す。

  • C

    2022.04
    -
    2025.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

    　View Summary

    分化異常は悪性腫瘍において広く認められる特徴の一つであり、そのメカニズムの解明は新規治療法の開発につながることが期待される。しかし、その詳細は多くの悪性腫瘍において不明である。申請者は、ある種のセロトニン受容体が頭頸部扁平上皮癌などの扁平上皮癌（SCC）において高発現し、また、予後不良と相関すること、さらには、分化を抑制することにより、悪性腫瘍の進展に寄与することを見出した。本研究では、SCCにおけるHTR7の機能に着目し、その発現・活性制御メカニズムと詳細な分化制御機構の解明を試みる。さらにはセロトニンシグナルによる分化制御機構を標的とし、SCCに対する分化誘導療法の開発を目指す。

  • 炎症性サイトカイン制御による骨破壊性疾患における抗炎症性作用機序の解明

    2021.08
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up , Principal investigator

    　View Summary

    ビタミンDの生理的作用は、多岐にわたるが、われわれは、炎症性骨破壊疾患に注目した。口腔内は、細菌が常に存在する空間であり、急性・慢性疾患を問わず人間が、炎症性口腔内疾患に罹患する。骨吸収薬剤関連顎骨壊死を代表とする顎骨の骨破壊性疾患に罹患すると審美性、食事の摂取などを含めた機能性を損ない、QOLが著しく低下する。本研究により炎症性サイトカイン制御による新たな炎症性骨破壊疾患の治療法を見出す可能性が考えられる。

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Awards 【 Display / hide 】

  • 第75回日本口腔科学会学術集会 Rising Scientist賞

    相馬智也, 2021.05, ゾレドロネート投与と侵襲的歯科処置は，炎症性サイトカインを上昇させ，骨吸収薬剤関連顎骨壊死を誘発する

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 第5回日本骨免疫学会 優秀演題賞

    Tomoya Soma, 2019.06, 骨吸収抑制薬による薬剤関連顎骨壊死には炎症性サイトカインの上昇が必須である

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Memberships in Academic Societies 【 Display / hide 】

  • Asian Association of Oral and Maxillofacial Surgeons, 

    2018.01
    -
    Present

  • Japanese Society of Oral and Maxillofacial Surgeons, 

    2009.08
    -
    Present

  • Japanese Society of Pediatric Oral and Maxillofacial Surgery, 

    2022.09
    -
    Present

  • The Japanese Cancer Association, 

    2022.05
    -
    Present

  • The Japanese Society for Bone and Mineral Research, 

    2019.11
    -
    Present

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