KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2024.10

  -

  Present

  Keio University School of Medicine, Department of Dentistry and Oral Surgery, Senior Assistant Professor

• 2025.04

  -

  Present

  慶應義塾大学病院, 歯科・口腔外科, 診療科医長（保険医長）

• 2023.04

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  Present

  慶應義塾大学病院, 小児・周産期医療センター

• 2021.04

  -

  2024.09

  慶應義塾大学医学部, 歯科・口腔外科学教室, 助教（有期・医学部）

• 2018.04

  -

  2020.03

  慶應義塾大学, 大学院医学研究科, 助教（有期・研究奨励Ⅲ）

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2017.04

  -

  2021.03

  Keio University, Graduate School of Medicine, Keio University

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Ph.D.in Medicine, Keio University, Coursework, 2021.03

  Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• （公社）日本口腔外科学会認定口腔外科指導医, 2024.04

• （公社）日本化学療法学会認定抗菌化学療法認定歯科医師, 2016.01

• （公社）日本口腔外科学会認定口腔外科専門医, 2020.04

• （一社）日本歯科専門医機構認定口腔外科専門医, 2020.04

• 日本がん治療認定医機構がん治療認定医 （歯科口腔外科）, 2021.04

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Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Surgical dentistry (Osteoclast・Bone metabolism)

• Life Science / Tumor biology

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• 薬剤関連顎骨壊死

• 骨代謝学

• Patient-dervied xenografts

• Oral cancer

• Antibacterial Dental Device

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Books 【 Display / hide 】

Books 【 Display / hide 】

• デンタルダイヤモンド 2022年2月号【巻頭特集】GPの疑問に答える！ 歯科小手術の勘どころ

  相馬智也, デンタルダイヤモンド社, 2022.02

  Scope: 粘液嚢胞・エプーリスの除去を安全に行うには？

• よくわかる歯科小手術の基本―抜歯から歯周外科まで

  相馬智也, 莇生田整治, デンタルダイヤモンド社, 2016.10,  Page： 141

  Scope: 全身状態・疾患への配慮

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• DC-STAMP and OC-STAMP cooperatively regulate osteoclast and foreign body giant cell cell-cell fusion

  Fuka Homma, Ryotaro Iwasaki, Makoto Tateyama, Tomoya Soma, Mayu Morita, Makiko Kashio, Taneaki Nakagawa, Takeshi Miyamoto

  Journal of Bone and Mineral Metabolism (Springer Science and Business Media LLC)   2025.12

  Research paper (scientific journal), Accepted,  ISSN  0914-8779

  　View Summary

  Abstract
  
  Introduction
  
  Osteoclasts and foreign body giant cells (FBGCs) are multi-nuclear cells established by fusion of their mono-nuclear forms. Multi-nucleation via cell–cell fusion is a common characteristic of osteoclasts and FBGCs, and Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) and Osteoclast Stimulatory Transmembrane Protein (OC-STAMP) are both required for the process. Thus, it is thought that DC-STAMP and OC-STAMP interaction likely induces this fusion, but details of these mechanisms are not clear.
  
  Materials and methods
  
  We crossed DC-STAMP knockout (KO) with OC-STAMP KO mice to obtain DC-STAMP/OC-STAMP doubly deficient (DKO) mice. Osteoclasts and FBGC common progenitors were isolated from wild-type (WT), DC-STAMP KO, OC-STAMP KO or DKO mice. We then set up 4 co-culture systems: (1) WT with DC-STAMP KO cells, (2) WT with OC-STAMP KO cells, (3) WT with DKO cells, and (4) DC-STAMP KO with OC-STAMP KO cells to induce osteoclast or FBGC formation. We evaluated osteoclast and FBGC formation by TRAP and May–Gruenwald Giemsa staining, respectively. Finally, we performed bone morphometric analysis of WT, DC-STAMP KO, OC-STAMP KO, and DKO mice.
  
  Results
  
  Cell–cell fusion occurs normally in co-cultures of DC KO with WT cells, OC KO with WT cells, and DKO with WT cells in both osteoclast and FBGC-inducing conditions. By contrast, co-cultures of DC-STAMP KO with OC-STAMP KO cells did not show cell–cell fusion. Bone morphometric analysis revealed enhanced bone formation in DKO mice.
  
  Conclusion
  
  DC-STAMP and OC-STAMP cooperate to promote osteoclast and FBGC cell–cell fusion. DC-STAMP and OC-STAMP doubly deficient mice exhibit increased osteogenesis.

  • Access to Document (DOI)

• A retrospective analysis of outcomes of non-operative therapy for medication-related osteonecrosis of the jaw

  Kanako Munakata, Hidetaka Miyashita, Yuka Yamada, Tomoya Soma, Seiji Asoda, Taneaki Nakagawa

  Journal of Oral and Maxillofacial Surgery (Elsevier BV)  83 ( 12 ) 1549 - 1559 2025.12

  Accepted,  ISSN  0278-2391

  　View Summary

  Background: Limited research is available regarding the role of nonoperative therapy in managing medication-related osteonecrosis of the jaw (MRONJ) as it relates to progression or resolution of disease. Purpose: The study purpose was to estimate the time to MRONJ stage improvement and risk for relapse among patients managed nonoperatively. Study Design, Setting, Sample: This retrospective cohort study included subjects diagnosed with MRONJ at Keio University Hospital between April 2012 and July 2024. Exclusion criteria included absence of a panoramic radiograph, prior operative therapy, or an observation period of less than 3 months. Predictor Variable: The predictor variable was a set of heterogeneous factors including age, sex, disease stage at the initial visit, presence of diabetes, use of steroid, radiographic findings, primary disease, type of bone-modifying agent (BMA), and BMA holiday before improvement. Disease stage after the stage improvement and BMA holiday after the disease improvement were included as covariates for evaluating the risk of relapse. Main Outcome Variable: The main outcome variable was therapeutic response measured as the time between initial treatment and MRONJ stage improvement, which was defined as an improvement of at least one stage. The secondary outcome was relapse measured as the time between maximal therapeutic response measured by MRONJ stage and worsening of the MRONJ stage. Analyses: The Fine-Gray subdistribution hazard model was used to estimate the cumulative incidence function (CIF) of outcomes, and Gray's test was used to compare CIF curves for relapse after stage improvement. Results: The sample was composed of 118 subjects with a mean age of 73.4 (±10.03), 54 (45.8%) were male, and the median interquartile range (IQR) duration of follow-up was 23 (11 to 32.5) months. During the study interval, 84 (71.2%) subjects achieved stage improvement, resulting in a 12-month CIF of 0.594. After achieving maximal therapeutic effect, 34 subjects (40.5%) experienced relapse. Incomplete healing after the stage improvement was associated with a higher risk of relapse (P = .0016), with a CIF of 0.661 at 36 months. Conclusions and Relevance: More than half of the subjects experienced stage improvement within 12 months. Incomplete healing following initial intervention may increase the risk of relapse.

  • Access to Document (DOI)

• Pseudoaneurysm developing after extraction of the mandibular third molar requiring transcatheter arterial embolization: A case report and literature review

  Tomoya Soma, Terumi Takeuchi, Kentaro Nishi, Kanako Munakata, Hiroki Nagamine, Taneaki Nakagawa, Seiji Asoda

  Journal of Dentomaxillofacial Science  2025.12

  Research paper (scientific journal), Lead author, Accepted

• In vivo responses of β-tricalcium phosphate–based paste-like artificial bone with antibacterial properties under potentially infectious conditions using a rabbit model

  H. Miyashita, Y. Kamaya, K. Suzuki, S. Kato, S. Morikawa, T. Soma, M. Nasu, K. Munakata, T. Nakagawa, M. Aizawa

  Journal of Materials Science: Materials in Medicine (Springer Science and Business Media LLC)  36 ( 1 ) 70 2025.08

  Accepted,  ISSN  0957-4530

  　View Summary

  Calcium-phosphate cement (CPC), a paste-like artificial bone, is a material form that allows minimally invasive treatment. However, CPC is not infection resistant, which may lead to surgical site infections. We recently developed a paste-like organic/inorganic hybrid artificial bone that is compatible with the bone remodeling cycle. In this study, we added silver-loaded tricalcium phosphate, which has antibacterial properties, to the hybrid CPC and fabricated a prototype “antibacterial CPC”. Antibacterial and non-antibacterial CPCs were implanted into a rabbit jaw defect model in which infection could occur, and the in vivo responses were compared. In cement specimens retrieved from rabbit jaws, residual material was observed with the non-antibacterial CPC, whereas with the antibacterial CPC, almost all of the material was resorbed and replaced with host bone. These results suggest that placement of antibacterial CPC in a rabbit jaw bone defect model susceptible to bacterial infection promotes material resorption and bone formation. The antibacterial CPC developed in this study is thus a novel paste artificial bone exhibiting good bioresorption and osteogenic potential in biological hard tissues. (Figure presented.)

  • Access to Document (DOI)

• Clinical practice and pathology of oral potentially malignant disorders and oral epithelial dysplasia following the revision of the WHO Classification of Head and Neck Tumours (5th Edition)

  Hisao Yagishita, Yoshihiko Akashi, Seiji Asoda, Ayataka Ishikawa, Yumi Ito, Toru Inomata, Hiroshi Kawachi, Yukiko Sato, Takafumi Satomi, Shoichi Sekikawa, Tomoya Soma, Seiko Tatehara, Takeshi Nomura, Satoshi Fujii, Kenichi Matsuzaka, Takuo Henmi, Yasuyuki Michi, Kazuhiro Yagihara, Masashi Yamashiro

  Journal of Japanese Society of Oral Oncology (Japan Society for Oral Tumors)  37 ( 2 ) 41 - 51 2025.06

  Accepted,  ISSN  0915-5988

  　View Summary

  It is well known that the World Health Organization （WHO） Classification of Head and Neck Tumours is an essential tool and glossary for standardizing diagnostic practices worldwide. This report provides an overview of the revisions to the WHO Classification of Head and Neck Tumours （5th edition） regarding oral potentially malignant disorders and oral epithelial dysplasia related to superficial lesions among epithelial tumors in the oral cavity. In 2017, the fourth edition of the WHO Classification of Head and Neck Tumours described oral potentially malignant disorders for the first time. A major topic at that time was the integration of the concepts of previous precancerous conditions and precancerous lesions. In this revision, three disorders were deleted, one was incorporated into a familial cancer syndrome, and three new disorders were added: proliferative verrucous leukoplakia, oral lichenoid lesions, and oral graft-versus-host disease. Oral epithelial dysplasia is defined as a lesion with oral potentially malignant disorders and carries a risk of malignant transformation to squamous cell carcinoma. The grading of oral epithelial dysplasia has become a histopathological evaluation tool for potentially malignant disorders of the oral cavity. On the other hand, the revisions to oral epithelial dysplasia may be interpreted as contradictory. We outline the issues and the Oral Superficial Cancer Working Group’s thinking on oral epithelial dysplasia.

  • Access to Document (DOI)
  • CiNii Research

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• ゾレドロネートを投与されたマウスにおける抜歯処置は、炎症性サイトカインを上昇させ、顎骨壊死を誘発する

  Sōma, Tomoya

  (慶應義塾大学大学院医学研究科)  2020

• ゾレドロネートを投与されたマウスにおける抜歯処置は、炎症性サイトカインを上昇させ、顎骨壊死を誘発する

  Sōma, Tomoya

  (慶應義塾大学大学院医学研究科)  2020

• ゾレドロネートを投与されたマウスにおける抜歯処置は、炎症性サイトカインを上昇させ、顎骨壊死を誘発する

  Sōma, Tomoya

  (慶應義塾大学大学院医学研究科)  2020

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 治療抵抗性頭頸部扁平上皮癌を標的とした治療薬の同定

  岡崎 章悟, 吉川 桃子, 相馬 智也, 莇生田 整治, 中島 由梨佳, 今井 健一

  日本歯科医師会雑誌 ((公社)日本歯科医師会)  78 ( 4 ) 384 - 384 2025.07

  ISSN  0047-1763

• 当科を受診した歯科治療に起因する縦隔気腫の臨床的検討

  木村 大志, 相馬 智也, 加藤 伸, 小林 夏樹, 莇生田 整治, 角田 和之, 中川 種昭

  日本口腔科学会雑誌 ((NPO)日本口腔科学会)  74 ( 2 ) 75 - 76 2025.07

  ISSN  0029-0297

• 炭酸アパタイトを使用したインプラント周囲炎の再生療法に関する観察研究

  宮下 英高, 堀江 伸行, 森川 曉, 古澤 春佳, 柴崎 竣一, 相馬 智也, 宗像 花楠子, 小高 利絵, 中川 種昭, 莇生田 整治

  顎顔面補綴 ((一社)日本顎顔面補綴学会)  48 ( 1 ) 55 - 55 2025.06

  ISSN  0389-4045

• Immobilization of silver ions on hydroxyapatite-coated titanium using inositol phosphate and its anti-bacterial property

  近藤葵, ZHU X.Y., 鈴木来, 宮下英高, 相馬智也, 那須真奈, 中川種昭, 森川暁, 相澤守

  日本セラミックス協会年会講演予稿集(Web) 2025 2025

• An observational study on regenerative therapy for peri-implantitis using carbonate apatite

  宮下英高, 堀江伸行, 森川曉, 古澤春佳, 柴崎竣一, 相馬智也, 宗像花楠子, 小高利絵, 中川種昭, 莇生田整治

  Japanese Journal of Maxillo Facial Implants ((公社)日本顎顔面インプラント学会)  23 ( 3 ) 148 - 148 2024.11

  ISSN  1347-894X

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• クロロヘキシジン担持 βリン酸三カルシウムを利用した抗菌性歯面洗浄剤の調製とその評価

  永島実莉, 大木隆聖, 近藤 葵, 宮下英高, 森川 暁, 相馬智也, 那須真奈, 中川種昭, 相澤 守

  [Domestic presentation]  第27回生体関連セラミックス討論会 (香川県 高松商工会議所会議室) , 

  2025.12

  , 

  Oral presentation (general), 公益社団法人日本セラミックス協会 生体関連材料部会

• 悪性骨軟部腫瘍の薬物療法における歯性感染症の検討

  山田有佳, 宗像花楠子, 木村大志, 臼田聡, 相馬智也, 宮下英高, 中川種昭, 莇生田整治

  [Domestic presentation]  第220回（公社）日本口腔外科学会関東支部学術集会 (神奈川県　神奈川県歯科医師会館) , 

  2025.12

  , 

  Oral presentation (general)

• 挿管困難症例に対し、声門下狭窄精査後に全身麻酔下手術を行った1例

  長嶺宏樹, 相馬智也, 二宮真希, 鶴田かほる, 木村大志, 宗像花楠子, 臼田聡, 宮下英高, 莇生田整治

  [Domestic presentation]  第37回日本小児口腔外科学会総会・学術大会 (香川県 香川県社会福祉総合センター) , 

  2025.12

  , 

  Oral presentation (general)

• 口腔顎顔面欠損患者における審美的インプラント治療

  河奈裕正, 永田紘大, 岩崎良太郎, 相馬智也, 宮下英高, 堀江伸行, 莇生田整治

  [Domestic presentation]  第29回日本顎顔面インプラント学会総会・学術大会 (島根県 松江テルサ) , 

  2025.11

  , 

  Symposium, workshop panel (nominated)

• Evaluation of oral function after mandibulectomy in patients with medication-related osteonecrosis of the jaw

  MUNAKATA Kanako, MIYASHITA Hidetaka, HORIE Nobuyuki, USUDA Sho, SOMA Tomoya, YAMADA Yuka, KIMURA Taishi, CHEN Akiteru, ASODA Seiji, NAKAGAWA Taneaki

  [Domestic presentation]  第29回日本顎顔面インプラント学会総会・学術大会 (島根県 松江テルサ) , 

  2025.11

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 力学的負荷を加えた多重障害インプラント周囲炎モデルの構築

  2024.10

  -

  Present

  公益社団法人日本顎顔面インプラント学会 , 第3回赤坂庸子若手研究奨励基金, Coinvestigator(s)

• 進行口腔扁平上皮癌に対するPCE導入化学療法による縮小手術の可能性についての検討

  2023.06

  -

  2024.08

  公益社団法人 日本口腔外科学会, 2022・2023年度研究助成「次世代若手臨床研究推進プロジェクト」, Coinvestigator(s)

• ビタミンD誘導体による難治性骨破壊性疾患の治療への応用

  2023.04

  -

  2026.03

  日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Principal investigator

  　View Summary

  口腔顎顔面外科領域では口腔内疾患の多くに骨吸収や骨破壊などを伴う炎症性疾患が多く認められる。ビスフォスフォネート製剤などによる骨吸収製剤の副作用である薬剤関連顎骨壊死も炎症を伴う骨破壊性疾患のひとつである。申請者はこれまで、ビスフォスフォネート製剤を投与したマウスモデルを用い、炎症性サイトカインが、骨壊死の発生や破骨細胞を介した骨破壊を引き起こすことを明らかにした。近年、ビタミンDの抗炎症作用が注目されており、そこで本研究では、炎症を伴う難治性骨破壊性疾患に対するビタミンDの分子メカニズムを解明し、新たな治療方法の確立を目指したい。

• C

  2022.04

  -

  2025.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

  　View Summary

  「口から食べること」による医学的効果は大きく、残存歯数が少ないほど、認知症の発症リスクが高くなるという負の関連を示す論文も公表され、健康寿命の延伸を果たすために、健全な口腔咀嚼機能の改善や構築は大きな課題であると考えられる。超高齢社会において「口から食べることを支援することによる健康寿命の延伸」に貢献するべく、安全な骨代謝機能と抗菌機能を兼ね備えた歯周組炎およびインプラント周囲炎骨再生材料を開発する。また、同様の抗菌システムを備えたインプラント周囲炎抵抗性デンタルインプラントシステムの開発を目指す。

• C

  2022.04

  -

  2025.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

  　View Summary

  分化異常は悪性腫瘍において広く認められる特徴の一つであり、そのメカニズムの解明は新規治療法の開発につながることが期待される。しかし、その詳細は多くの悪性腫瘍において不明である。申請者は、ある種のセロトニン受容体が頭頸部扁平上皮癌などの扁平上皮癌（SCC）において高発現し、また、予後不良と相関すること、さらには、分化を抑制することにより、悪性腫瘍の進展に寄与することを見出した。本研究では、SCCにおけるHTR7の機能に着目し、その発現・活性制御メカニズムと詳細な分化制御機構の解明を試みる。さらにはセロトニンシグナルによる分化制御機構を標的とし、SCCに対する分化誘導療法の開発を目指す。

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Awards 【 Display / hide 】

Awards 【 Display / hide 】

• JBMM Excellent Paper Award

  Tomoya Soma, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Satoshi Nakamura, Yosuke Kaneko, Eri Ito, Hiroyuki Okada, Hisato Watanabe, Kana Miyamoto, Morio Matsumoto, Masaya Nakamura, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Takeshi Miyamoto, 2024.07, The Japanese Society for Bone and Mineral Research, Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 第75回日本口腔科学会学術集会 Rising Scientist賞

  相馬智也, 森田麻友, 岩崎良太郎, 莇生田整治, 河奈裕正, 中川種昭, 宮本健史, 2021.05, ゾレドロネート投与と侵襲的歯科処置は，炎症性サイトカインを上昇させ，骨吸収薬剤関連顎骨壊死を誘発する

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 第5回日本骨免疫学会 優秀演題賞

  相馬智也, 森田麻友, 岩崎良太郎, 中川種昭, 宮本健史, 2019.06, 骨吸収抑制薬による薬剤関連顎骨壊死には炎症性サイトカインの上昇が必須である

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 日本歯科医学会ポスター賞（若手研究者部門）

  岡﨑章悟, 吉川桃子, 相馬智也, 莇生田整治, 中島由梨佳, 今井健一, 2025.09, 第25回日本歯科医学会学術大会, 治療抵抗性頭頸部扁平上皮癌を標的とした治療薬の同定

  Type of Award： Award from Japanese society, conference, symposium, etc.

• 第36回日本小児口腔外科学会優秀発表賞（ポスター発表）

  永田香織, 臼田慎, 二宮真希, 長嶺宏樹, 佐藤晃子, 赤田晋也, 遠藤友樹, 相馬智也, 莇生田整治, 木津英樹, 2024.11, 第36回日本小児口腔外科学会総会・学術大会, 小児萌出遅延歯に対する開窓・牽引療法の検討

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• Asian Association of Oral and Maxillofacial Surgeons, 

  2018.01

  -

  Present

• Japanese Society of Oral and Maxillofacial Surgeons, 

  2009.08

  -

  Present

• 全国病院歯科医協会, 

  2025.10

  -

  Present

• Japanese Society of Pediatric Oral and Maxillofacial Surgery, 

  2022.09

  -

  Present

• The Japanese Cancer Association, 

  2022.05

  -

  Present

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