Yamada, Yoshitake

写真a

Affiliation

School of Medicine, Department of Radiology (Diagnostic Radiology) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links

Profile 【 Display / hide

  • Sep 2005-present: Board Certified Membership of the Japanese Society of Internal Medicine
    Sep 2010-present: Board Certified Diagnostic Radiologist of the Japan Radiological Society
    Aug 2013-present: Specialist in Positron Emission Tomography in the Japanese Board of Nuclear Medicine
    July 2015-present: Specialist in the Japanese Board of Nuclear Medicine
    October 2018-present: Board Certified Fellow of the Japan Society of Ultrasonics in Medicine

Career 【 Display / hide

  • 2017.01
    -
    Present

    Department of Radiology, Keio University School of Medicine

  • 2016.01
    -
    2016.12

    Harvard Medical School, Brigham and Women’s Hospital , Radiology

  • 2010.04
    -
    2015.12

    Department of Radiology, Keio University School of Medicine

  • 2008.04
    -
    2010.03

    Department of Radiology, Nippon Koukan Hosptal

  • 2006.04
    -
    2008.03

    Department of Radiology, Keio University School of Medicine

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Academic Background 【 Display / hide

  • 1996.04
    -
    2002.03

    Keio University, School of Medicine

    University, Graduated

  • 2010.04
    -
    2013.03

    Keio University, 医学研究科

    Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Coursework, 2013.03

Licenses and Qualifications 【 Display / hide

  • Board certified diagnostic radiologist of the Japan Radiological Society, 2010.09

  • Specialist in the Japanese Board of Nuclear Medicine, 2015.07

  • Specialist in Positron Emission Tomography in the Japanese Board of Nuclear Medicine, 2013.08

  • Board Certified Fellow of the Japan Society of Ultrasonics in Medicine, 2018.10

  • 日本乳がん検診精度管理中央機構 検診マンモグラフィ読影認定医, 2008.10

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Research Areas 【 Display / hide

  • Life Science / Radiological sciences

Research Keywords 【 Display / hide

  • Diagnostic Radiology

  • CT

  • Chest imaging

  • Cardiovascular imaging

  • Abdominal imaging

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Research Themes 【 Display / hide

  • Multidetector computed tomography, 

    2010.04
    -
    Present

  • Chest imaging, 

    2010.04
    -
    Present

  • Cardiovascular imaging, 

    2010.04
    -
    Present

  • Abdominal imaging, 

    2010.04
    -
    Present

  • Dual-energy CT, 

    2010.04
    -
    Present

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Books 【 Display / hide

  • ここから始める循環器疾患のCT・MRI

    Yoshitake YAMADA, 学研メディカル秀潤社, 2020.04

    Scope: fractional flow reserve computed from CT (FFRCT),  Contact page: p.102-103

  • 救急疾患の鑑別診断のポイント

    Hiroaki Sugiura, Yasuhiro Minami, Yoshitake Yamada, Masahiro Jinzaki, 学研メディカル秀潤社, 2019.09

    Scope: 肺間質影の鑑別,  Contact page: p.210-215

  • 救急疾患の鑑別診断のポイント

    Yasuhiro Minami, Yoshitake Yamada, Hiroaki Sugiura, Masahiro Jinzaki, 学研メディカル秀潤社, 2019.09

    Scope: 肺野空洞性病変の鑑別,  Contact page: p.204-209

  • Abdominal CT

    Yoshitake YAMADA, メディカルサイエンスインターナショナル, 2017.04

    Scope: XII. 腹部大動脈・下大静脈,  Contact page: p591-612

  • Abdominal CT

    Yoshitake YAMADA, メディカルサイエンスインターナショナル, 2017.04

    Scope: II.検査法,  Contact page: p37-44

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Papers 【 Display / hide

  • Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis.

    Chubachi S, Okamori S, Yamada Y, Yamada M, Yokoyama Y, Niijima Y, Kamata H, Ishii M, Fukunaga K, Jinzaki M

    Scientific reports 12 ( 1 ) 19408 2022.11

  • Comparison of Lung, Lobe, and Airway Volumes between Supine and Upright Computed Tomography and Their Correlation with Pulmonary Function Test in Patients with Chronic Obstructive Pulmonary Disease.

    Yamada Y, Chubachi S, Yamada M, Yokoyama Y, Tanabe A, Matsuoka S, Niijima Y, Murata M, Fukunaga K, Jinzaki M

    Respiration; international review of thoracic diseases    1 - 11 2022.11

    ISSN  0025-7931

  • Projected lung area using dynamic X-ray (DXR) with a flat-panel detector system and automated tracking in patients with chronic obstructive pulmonary disease (COPD).

    Hino T, Tsunomori A, Fukumoto T, Hata A, Hida T, Yamada Y, Ueyama M, Kamitani T, Nishino M, Kurosaki A, Jinzaki M, Ishigami K, Honda H, Yoneyama T, Nagatsuka S, Kudoh S, Hatabu H

    European journal of radiology (European Journal of Radiology)  157   110546 2022.09

    ISSN  0720-048X

     View Summary

    Objectives: To assess the association of projected lung area (PLA) measured by DXR with demographic data, pulmonary function, and COPD severity, and to generate PLA over time curves using automated tracking. Methods: This retrospective study recruited healthy volunteers and COPD patients. Participants were classified into three groups: normal, COPD mild and COPD severe. PLA was calculated from the manually traced bilateral lung contours. PLA over time curves were produced using automated tracking, which was used to calculate slope and intercept by approximate line during forced expiration. The correlation of PLA, difference of PLA between end-inspiration and end-expiration (ΔPLA), slope, and intercept with demographic data and pulmonary function tests were investigated. The difference of PLA, ΔPLA, intercept, and slope among three groups were also evaluated. Results: This study enrolled 45 healthy volunteers and 32 COPD patients. COPD severe group had larger PLA in both lungs at tidal/forced end-inspiration/expiration, smaller slope, and larger intercept than normal group (p < 0.001). PLA was correlated with % forced expiratory volume in one second (%FEV1) (rs from −0.42 to −0.31, p ≤ 0.01). ΔPLA in forced breathing showed moderate correlation with vital capacity (VC) (rs = 0.58, p < 0.001), while ΔPLA in tidal breathing showed moderate correlation with %FEV1 (rs = -0.52, p < 0.001) as well as mild correlation with tidal volume (rs = 0.24, p = 0.032). Intercept was slightly underestimated compared with manually contoured PLA (p < 0.001). Conclusion: COPD patients had larger PLA than healthy volunteers. PLA and ΔPLA in tidal breathing showed mild to moderate correlation with %FEV1.

  • Validation of deep learning-based computer-aided detection software use for interpretation of pulmonary abnormalities on chest radiographs and examination of factors that influence readers' performance and final diagnosis.

    Toda N, Hashimoto M, Iwabuchi Y, Nagasaka M, Takeshita R, Yamada M, Yamada Y, Jinzaki M

    Japanese journal of radiology (Japanese Journal of Radiology)   2022.09

    ISSN  1867-1071

     View Summary

    Purpose: To evaluate the performance of a deep learning-based computer-aided detection (CAD) software for detecting pulmonary nodules, masses, and consolidation on chest radiographs (CRs) and to examine the effect of readers’ experience and data characteristics on the sensitivity and final diagnosis. Materials and methods: The CRs of 453 patients were retrospectively selected from two institutions. Among these CRs, 60 images with abnormal findings (pulmonary nodules, masses, and consolidation) and 140 without abnormal findings were randomly selected for sequential observer-performance testing. In the test, 12 readers (three radiologists, three pulmonologists, three non-pulmonology physicians, and three junior residents) interpreted 200 images with and without CAD, and the findings were compared. Weighted alternative free-response receiver operating characteristic (wAFROC) figure of merit (FOM) was used to analyze observer performance. The lesions that readers initially missed but CAD detected were stratified by anatomic location and degree of subtlety, and the adoption rate was calculated. Fisher’s exact test was used for comparison. Results: The mean wAFROC FOM score of the 12 readers significantly improved from 0.746 to 0.810 with software assistance (P = 0.007). In the reader group with < 6 years of experience, the mean FOM score significantly improved from 0.680 to 0.779 (P = 0.011), while that in the reader group with ≥ 6 years of experience increased from 0.811 to 0.841 (P = 0.12). The sensitivity of the CAD software and the adoption rate for the lesions with subtlety level 2 or 3 (obscure) lesions were significantly lower than for level 4 or 5 (distinct) lesions (50% vs. 93%, P < 0.001; and 55% vs. 74%, P = 0.04, respectively). Conclusion: CAD software use improved doctors’ performance in detecting nodules/masses and consolidation on CRs, particularly for non-expert doctors, by preventing doctors from missing distinct lesions rather than helping them to detect obscure lesions.

  • Changes in the lumbar intervertebral foramen between supine and standing posture in patients with adult spinal deformity: a study with upright computed tomography.

    Fujita N, Yagi M, Yamada Y, Yokoyama Y, Yamada M, Watanabe K, Nakamura M, Nagura T, Jinzaki M

    Skeletal radiology (Skeletal Radiology)   2022.09

    ISSN  0364-2348

     View Summary

    Objective: To quantitatively assess the impact of supine and standing positions on the morphological changes in the lumbar intervertebral foramen (LIF) in patients with adult spinal deformity (ASD) using upright CT and conventional supine CT. Materials and methods: Thirty patients with ASD were prospectively enrolled in this study. All subjects underwent standing whole spine posterior/anterior radiographs, lateral radiographs, and whole spine CT, both in the supine and upright standing positions. Two orthopedic surgeons independently measured nine radiographic parameters in the radiograph and the lumbar foraminal area (FA) and height (FH) in supine and upright CT. Statistical analyses were performed to evaluate the risk of LIF decrease when standing upright compared to the supine position. The chi-squared, t test, Pearson’s coefficients, intra- and inter-rater reliabilities, and ROC curves were calculated. The level of significance was set at p < 0.05. Results: Among the 300 LIFs, both the lumbar FA and FH were either increased or decreased by > 5% in approximately 30% of LIFs each. The FA decreased in the lower lumbar spine. The concave side had a significantly higher rate of decreased FA and FH than the convex side (p < 0.05 and < 0.05, respectively). ROC analysis showed that narrowing of the intervertebral disc (cutoff > 0.05°) is a risk factor for decreased FA and FH. Conclusions: This study describes the details of the changes in the neuroforamen using a novel upright CT. In patients with ASD, approximately 30% of LIFs either increased or decreased in size by > 5% when standing. The risk factors for LIF decrease are the lower lumbar spine, concave side, and narrow side of the disc wedge.

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Reviews, Commentaries, etc. 【 Display / hide

  • 【胸部の最新画像情報2020】肺野の画像所見が診断の契機となったEhlers-Danlos症候群の1例

    松本 晋作, 杉浦 弘明, 南 康大, 山田 祥岳, 渡辺 理沙, 福永 興壱, 陣崎 雅弘

    臨床放射線 (金原出版(株))  65 ( 1 ) 67 - 70 2020.01

    Other, Joint Work,  ISSN  0009-9252

     View Summary

    症例は40歳代女性で、胸痛を主訴に近医を受診し、胸部単純X線で左気胸を指摘され当院へ紹介入院となった。胸部単純CTにて左気胸を認めた。両肺底部に複数の不整な嚢胞、両下葉に浸潤影、小葉中心性陰影および気管支拡張を認めた。なお、約1年前の肺炎時のCTでは嚢胞は認められなかった。胸腔ドレーンを留置するも気胸およびリークの改善を認めなかったため、胸腔鏡下左肺下葉嚢胞切除術を施行した。術後経過は良好で、術後約1週間で退院した。比較的若年者に繰り返す肺炎後に不整な嚢胞が散見され、難治性の気胸を発症したことから肺組織の脆弱性が示唆され、基礎疾患としてEhlers-Danlos症候群の可能性が疑われた。遺伝子検査ではCOL5A2遺伝子変異が陽性(ミスセンス変異)であり、古典型Ehlers-Danlos症候群と診断された。また、COL3A1遺伝子変異は陰性であったことから、血管型Ehlers-Danlos症候群は否定された。

  • A case of Ehlers-Danlos syndrome in which lung CT findings contributed to the diagnosis

    松本 晋作, 杉浦 弘明, 南 康大, 山田 祥岳, 渡辺 理沙, 福永 興壱, 陣崎 雅弘

    臨床放射線 (金原出版(株))  65 ( 1 ) 67 - 70 2020.01

    Other, Joint Work,  ISSN  0009-9252

  • DAT SPECTにおけるCSFマスク補正のSBR値の診断能への影響

    岩渕 雄, 中原 理紀, 亀山 征史, 松坂 陽至, 南 康大, 伊東 大介, 田渕 肇, 山田 祥岳, 陣崎 雅弘

    核医学 ((一社)日本核医学会)  56 ( Suppl. ) S175 - S175 2019.10

    Other, Joint Work,  ISSN  0022-7854

  • 肺野異常陰影 3 肺間質影の鑑別

    杉浦弘明, 南康大, 山田祥岳, 陣崎雅弘

    画像診断 39 ( 11 ) A210‐215 2019.09

    Other, Joint Work,  ISSN  0285-0524

  • 肺野異常陰影 2 肺野空洞性病変の鑑別

    南康大, 山田祥岳, 杉浦弘明, 陣崎雅弘

    画像診断 39 ( 11 ) A204‐A209 2019.09

    Other, Joint Work,  ISSN  0285-0524

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Presentations 【 Display / hide

  • 変形性膝関節症患者における扁平足の進行と膝関節アライメントの関連性 三次元立位CTによる検討

    伯川 聡志, 金田 和也, 原藤 健吾, 大木 聡, 山田 祥岳, 小林 秀, 二木 康夫, 名倉 武雄, 陣崎 雅弘, 中村 雅也

    日本整形外科学会雑誌, 

    2022.09

    (公社)日本整形外科学会

  • 立位四次元CTを用いた胸鎖関節および肩鎖関節の三次元動態解析

    吉田 勇樹, 松村 昇, 山田 祥岳, 山田 稔, 横山 陽一, 宮本 梓, 中村 雅也, 名倉 武雄, 陣崎 雅弘

    日本整形外科学会雑誌, 

    2022.09

    (公社)日本整形外科学会

  • 全身撮影可能な立位CTを用いた骨盤臓器脱評価の初期経験

    横山 陽一, 寺西 悠, 山田 祥岳, 山田 稔, 田中 伸之, 篠島 利明, 朝倉 博孝, 大家 基嗣, 陣崎 雅弘

    日本女性骨盤底医学会プログラム・抄録集, 

    2022.07

    日本女性骨盤底医学会

  • 顔面の可動性に着目したフェイシャルマッサージ効果の要因に関する解剖学的・画像診断学的考察

    奥田 逸子, 山田 稔, 山田 祥岳, 横山 陽一, 秋田 恵一, 陣崎 雅弘

    日本抗加齢医学会総会プログラム・抄録集, 

    2022.06

    (一社)日本抗加齢医学会

  • 立位CTの開発と荷重下CTイメージング

    山田 祥岳, 山田 稔, 名倉 武雄, 横山 陽一, 松本 守雄, 中村 雅也, 陣崎 雅弘

    Journal of Spine Research, 

    2022.03

    (一社)日本脊椎脊髄病学会

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Elucidation of human body function using upright CT ~Looking at the era of healthy longevity~

    2021.04
    -
    2024.03

    Keio University, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

     View Summary

    これまでのCTは患者さんが仰向けに寝た臥位の静止撮影で、器質的疾患の定量・定性評価を担ってきた。それにより、生命予後の改善に貢献してきたが、動態である機能の定量・定性評価はほとんどできていなかった。現在は、超高齢化社会であり、生命予後と同時に健康長寿であることもとても重要である。
    我々は、立位や座位での4次元画像が可能なCT(立位/座位CT)を開発した。これを用いて、健康長寿に必須である嚥下機能・排尿機能・歩行機能を健常人および患者さんにおいて3次元・4次元的に解明し、機能障害の機序と重症度分類、機能改善の指標になる所見を明らかにしていきたい。

  • 力学解析向け個別人体相同モデル生成手法の開発

    2021.04
    -
    2024.03

    National Institute of Advanced Industrial Science and Technology, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

     View Summary

    本研究は、以下の3つの研究題目からなる。1) 個人別人体ボリュームモデル構築手法の開発:ボディスキャナから得られた個人の人体表皮形状から、CT画像テンプレートを使用して個人の人体ボリュームモデルを構築する。2) 個人別人体力学特性の同定手法の開発:1)より得られた個人の人体ボリュームモデルにもとづき、標準動作の計測データを入力として、個人の人体力学特性を同定する。3) 筋活性度に基づく力知覚量推定手法の開発:自身が発揮する接触力の大きさについて、どのように知覚しているかを、筋活性度を用いてモデル化する。

  • Diagnosis and treatment of lymphatic diseases using MR lymphangiography, photoacoustic imaging, and upright CT

    2021.04
    -
    2024.03

    Keio University, Grant-in-Aid for Scientific Research (C), No Setting

     View Summary

    リンパ疾患はリンパ浮腫だけでも世界に1.7億人の患者がおり、癌患者の増加、手術の高度化などを背景に増加している。しかしリンパ系は殆どの疾患で診断も治療も十分に確立されていない。この主な原因はリンパ管の簡便な画像診断がなく、現在でも可視化が容易ではない事にある。従って、画像診断の進歩によるリンパ管の可視化と動態の解明が、これらの診療と研究を導くキーである。本研究では、先進的MRイメージングと独自のマルチモダリティアプローチにより、リンパ系の新規画像診断法の確立を目指す。リンパ管画像診断のレベルを押し上げ、より低侵襲で精密な治療へ展開する事で、リンパ管疾患に苦しむ多くの患者に福音をもたらしたい。

  • 逐次近似法再構成冠動脈CTが臨床転帰に与える影響に関する多施設無作為化比較試験

    2020.04
    -
    2024.03

    Tohoku University, Grant-in-Aid for Scientific Research (C), No Setting

     View Summary

    近年,CT装置の発展に伴い,従来法の冠動脈CT撮影法と比較して,より低被曝で撮像できる,逐次近似法を用いた冠動脈CT検査が臨床に導入されてきた.しかし,新たなCT検査法が,従来の方法と比較して,患者の診療に同等の価値を与えているかどうか,明確なエビデンスが不足している.
    本研究では,従来の冠動脈CT検査法と新たな検査法を比較して,その後の患者の診療の流れ,および臨床的な転帰を比較検討する.本研究は国内多施設が参加する無作為化比較試験である.

  • Elucidation of undetermined pathological mechanism and quantification of the diseases that demonstrate more relevant symptoms in the standing position than in the supine position by using upright CT

    2020.04
    -
    2023.03

    Keio University, Grant-in-Aid for Scientific Research (C), No Setting

     View Summary

    現在の画像診断学において、CTは単純X線写真よりも基本的に診断能が高い。ただし、単純X線写真は立位で撮影可能であるが、CTは立位で撮影できない、という決定的な違いがあった。現在の通常のCTは臥位で撮影されるため、ヒトの日常生活の状態(立位/座位)を反映しておらず、立位で増悪する病態を3次元的に画像化できていなかった。そこで我々は、国内メーカーと共同で320列立位CTを開発し、慶應義塾大学病院に世界第1号機を導入した(座位撮影も可能)。本研究では、新たな診断機器である立位CTを用いて、立位で症状が増悪する疾患の病態を画像的に明らかにし、立位/座位での新たな画像診断法の確立と病態の定量化を目指す。

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Awards 【 Display / hide

  • Magna Cum Laude award at the 102nd Scientific Assembly and Annual Meeting of the Radiological Society of North America

    2016.11, Radiological Society of North America, Dynamic Chest Radiography Using Flat Panel Detector System: Technique and Applications

    Type of Award: Award from international society, conference, symposium, etc.,  Country: United States

  • Platinum Medal (the Best Presentation Award) at the 79rd Annual Meeting of the Japan Radiological Society

    Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Mitsuru Murata, Koichi Fukunaga, Shotaro Chubachi, Masahiro Jinzaki, 2020.06, Japan Radiological Society, Comparison of Inspiratory and Expiratory Lung/Lobe Volumes Among Supine, Standing and Sitting Positions scanned with Conventional and 320-Detector-Row Upright CT

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • Certificate of Merit Award at the 103rd Scientific Assembly and Annual Meeting of the Radiological Society of North America

    2017.11, Radiological Society of North America, Four-dimensional (4D) Computed Tomography (CT) with Non-rigid Registration Between Adjacent Phases Before and After Transcatheter Aortic Valve Implantation (TAVI): One Step Forward Into the Future

    Type of Award: Award from international society, conference, symposium, etc.,  Country: United States

  • Achievement Award, Japanese Society of Medical Imaging Technology

    Masahiro Jinzaki, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Takeo Nagura, Naomichi Ogihara, Yasutaka Shindo, Makoto Nakano, 2022.07, Japanese Society of Medical Imaging Technology, Development of Whole-Body Upright Computed Tomography

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • Silver Medal, the 80th Annual Meeting of the Japan Radiological Society

    Yoshitake Yamada, Shotaro Chubachi, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Mitsuru Murata, Koichi Fukunaga, Masahiro Jinzaki, 2021.04, Japan Radiological Society, Correlation between lung volumes on upright CT and measurements on pulmonary function test in COPD patients: comparison with supine CT

    Type of Award: Award from Japanese society, conference, symposium, etc.

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Other 【 Display / hide

  • JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases: Cooperator

    2019年03月

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    JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases: Cooperator

  • 2016年01月

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    The Uehara Memorial Foundation, Overseas research fellowships

 

Courses Taught 【 Display / hide

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2022

  • Diagnostic imaging of the chest

    2020, Full academic year, Laboratory work/practical work/exercise, Within own faculty, 110people

  • Medical interview

    2020, Laboratory work/practical work/exercise, 110people

  • Diagnostic imaging: Chest (Respiratory System)

    2020, Full academic year, Laboratory work/practical work/exercise, Within own faculty, 110people

Courses Previously Taught 【 Display / hide

  • 肝・胆・膵の画像診断

    慶應義塾大学医学部

    2018.04
    -
    2019.03

  • 骨盤腔の画像診断

    慶應義塾大学医学部

    2018.04
    -
    2019.03

  • 肝・胆・膵の画像診断

    Keio University

    2017.04
    -
    2018.03

    Full academic year

  • 肝・胆・膵の画像診断

    Keio University

    2015.04
    -
    2016.03

    Full academic year, Laboratory work/practical work/exercise

  • 女性骨盤臓器の画像診断

    Keio University

    2015.04
    -
    2016.03

    Full academic year, Laboratory work/practical work/exercise

Educational Activities and Special Notes 【 Display / hide

  • The person in charge of Objective Structured Clinical Examination

    2019.04
    -
    Present

    , Special Affairs

 

Memberships in Academic Societies 【 Display / hide

  • Japan Radiological Society, 

    2006
    -
    Present
  • The Japan Society of Ultrasonics in Medicine, 

    2014
    -
    Present
  • The Japanese Society of Nuclear Medicine, 

    2013
    -
    Present
  • Radiological Society of North America, 

    2010
    -
    Present
  • The Japanese Circulation Society, 

    2014
    -
    Present

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