Yamada, Yoshitake

写真a

Affiliation

School of Medicine, Department of Radiology (Diagnostic Radiology) (Shinanomachi)

Position

Associate Professor

External Links
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Profile 【 Display / hide 】

  • Sep 2005-present: Board Certified Membership of the Japanese Society of Internal Medicine
    Sep 2010-present: Board Certified Diagnostic Radiologist of the Japan Radiological Society
    Aug 2013-present: Specialist in Positron Emission Tomography in the Japanese Board of Nuclear Medicine
    July 2015-present: Specialist in the Japanese Board of Nuclear Medicine
    October 2018-present: Board Certified Senior Fellow of the Japan Society of Ultrasonics in Medicine

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Career 【 Display / hide 】

  • 2017.01
    -
    Present

    Department of Radiology, Keio University School of Medicine

  • 2016.01
    -
    2016.12

    Harvard Medical School, Brigham and Women’s Hospital , Radiology

  • 2010.04
    -
    2015.12

    Department of Radiology, Keio University School of Medicine

  • 2008.04
    -
    2010.03

    Department of Radiology, Nippon Koukan Hosptal

  • 2006.04
    -
    2008.03

    Department of Radiology, Keio University School of Medicine

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Academic Background 【 Display / hide 】

  • 1996.04
    -
    2002.03

    Keio University, School of Medicine

    University, Graduated

  • 2010.04
    -
    2013.03

    Keio University, 医学研究科

    Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, Coursework, 2013.03

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Licenses and Qualifications 【 Display / hide 】

  • Board certified diagnostic radiologist of the Japan Radiological Society, 2010.09

  • Specialist in the Japanese Board of Nuclear Medicine, 2015.07

  • Specialist in Positron Emission Tomography in the Japanese Board of Nuclear Medicine, 2013.08

  • Board Certified Fellow of the Japan Society of Ultrasonics in Medicine, 2018.10

  • 日本乳がん検診精度管理中央機構 検診マンモグラフィ読影認定医（指導医認定 AS）, 2008.10

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Research Areas 【 Display / hide 】

  • Life Science / Radiological sciences

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Research Keywords 【 Display / hide 】

  • Diagnostic Radiology

  • CT

  • Chest imaging

  • Cardiovascular imaging

  • Abdominal imaging

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Research Themes 【 Display / hide 】

  • Multidetector computed tomography, 

    2010.04
    -
    Present

  • Chest imaging, 

    2010.04
    -
    Present

  • Cardiovascular imaging, 

    2010.04
    -
    Present

  • Abdominal imaging, 

    2010.04
    -
    Present

  • Dual-energy CT, 

    2010.04
    -
    Present

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Books 【 Display / hide 】

  • ここから始める循環器疾患のCT・MRI

    Yoshitake YAMADA, 学研メディカル秀潤社, 2020.04

    Scope: fractional flow reserve computed from CT (FFRCT),  Contact page： p.102-103

  • 救急疾患の鑑別診断のポイント

    Yasuhiro Minami, Yoshitake Yamada, Hiroaki Sugiura, Masahiro Jinzaki, 学研メディカル秀潤社, 2019.09

    Scope: 肺野空洞性病変の鑑別,  Contact page： p.204-209

  • 救急疾患の鑑別診断のポイント

    Hiroaki Sugiura, Yasuhiro Minami, Yoshitake Yamada, Masahiro Jinzaki, 学研メディカル秀潤社, 2019.09

    Scope: 肺間質影の鑑別,  Contact page： p.210-215

  • Abdominal CT

    Yoshitake YAMADA, メディカルサイエンスインターナショナル, 2017.04

    Scope: XII. 腹部大動脈・下大静脈,  Contact page： p591-612

  • Abdominal CT

    Yoshitake YAMADA, メディカルサイエンスインターナショナル, 2017.04

    Scope: II.検査法,  Contact page： p37-44

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Papers 【 Display / hide 】

  • Future Applications of Cardiothoracic CT.

    Schiebler ML, Jinzaki M, Yanagawa M, Pourmorteza A, Yamada Y, Kato Y, Wada N, Schaefer-Prokop C, Dousset V, Tomiyama N, Prokop M, Lima JA, Hatabu H

    Radiology 315 ( 3 ) e240085 2025.06

    ISSN  0033-8419

  • Imaging of the umbilicus.

    Yagi F, Akita H, Yamada Y, Jinzaki M

    Abdominal radiology (New York)  2025.05

  • Simulation Study of Upright Prostate Radiation Therapy: Comparison of Upright and Supine Anatomy and Dose-Volumetric Factors.

    Oguma K, Yamada Y, Koike N, Fukada J, Yamada M, Yokoyama Y, Takeda A, Shigematsu N, Jinzaki M

    Practical radiation oncology  2025.04

    ISSN  1879-8500

    　View Summary

    Purpose: This study aimed to assess the feasibility of upright radiation therapy for prostate cancer, compared to conventional supine radiation therapy, by quantitatively evaluating anatomic changes and their dosimetric impact through treatment planning simulations based on paired upright and supine positioning computed tomography (CT) images. Methods and Materials: This study compared pelvic organ anatomies and dose distributions, in hypothetical prostate cancer patients, between upright and supine prostate radiation therapy using paired CT images from asymptomatic volunteers. Anatomic changes in pelvic organ position, shape, volume, and rectal gas were quantitatively evaluated. Prostate radiation therapy was simulated on these CT images for volumetric modulated arc therapy with a prescribed dose of 60 Gy in 20 fractions. Dosimetric comparisons were performed using dose-volume histogram parameters based on a clinical protocol. Results: Fifty-one asymptomatic volunteers were registered. Compared to the supine position, pelvic organs in the upright position moved inferiorly (prostate: 2.8 mm ± 5.2, rectum: 2.9 mm ± 5.8, bladder: 3.7 mm ± 6.9, bowel: 25.2 mm ± 18.6; all P < .001). Rectal gas moved superiorly (4.8 mm ± 11.9; P = .004) and posteriorly (10.7 mm ± 23.5; P = .008). All dose-volume histogram parameters met the dose constraints, and the dose distributions of the upright and supine plans were clinically comparable in terms of organ-at-risk sparing and target coverage (P > .05). In some cases, the rectum curved more posteriorly in the upright position, allowing better sparing of high-dose areas, and the bladder moved inferiorly while expanding in the anterior-posterior direction in the upright position, preventing the small bowel from dropping into the radiation field. Conclusions: Our treatment planning simulation showed that upright radiation therapy for prostate cancer is feasible with a dose distribution comparable to that of conventional supine radiation therapy, despite significant anatomic changes in pelvic organ positioning between the upright and supine patient positions.

  • Long-Term Impact of Early Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve Implantation.

    Iwata J, Hayashida K, Arita R, Moriizumi T, Kajino A, Sakata S, Ryuzaki T, Shinada K, Tsuruta H, Yamada Y, Kato J, Takahashi T, Yamazaki M, Jinzaki M, Shimizu H, Ieda M

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 105 ( 5 ) 1161 - 1170 2025.04

    ISSN  1522-1946

    　View Summary

    Background: Hypoattenuated leaflet thickening (HALT) after transcatheter aortic valve implantation (TAVI) detected on multidetector computed tomography (MDCT) is considered leaflet thrombosis. However, its impact on long-term clinical outcomes remains unclear. This study aimed to investigate the impact of early HALT detection after TAVI on long-term clinical outcomes and structural valve deterioration beyond 6 years. Methods: Of the 672 consecutive patients who underwent TAVI between 2013 and 2018, 448 were treated with either SAPIEN XT or SAPIEN 3 and underwent MDCT analysis within 30 days after TAVI. MDCT results and echocardiographic data were analyzed annually. Results: HALT was detected in 68 (15.2%) of 448 eligible patients within 30 days after TAVI. No significant difference in effective orifice area was observed by echocardiography within 30 days after TAVI between the HALT and the non-HALT groups in SAPIEN XT (HALT vs. non-HALT: 1.62 ± 0.66 cm2 vs. 1.72 ± 0.43 cm2; p = 0.26) and in SAPIEN 3 (1.42 ± 0.35 cm2 vs. 1.45 ± 0.34 cm2; p = 0.63). No significant differences in all-cause mortality (52.9% vs. 60.0%; hazard ratio (HR): 1.19; 95% confidence interval (CI): 0.83−1.70; p = 0.3), stroke incidence (5.9% vs. 7.1%; HR: 1.06; 95% CI: 0.08−13.7; p = 0.97), heart failure rehospitalization (10.3% vs. 15.0%; HR: 2.3; 95% CI: 0.89−5.99; p = 0.09), and structural valve deterioration (14.7% vs. 17.9%; HR: 0.89; 95% CI: 0.45−1.73; p = 0.73) were observed between the HALT and the non-HALT groups during the median follow-up of 1872 (interquartile range; 1203−2468) days. Conclusions: HALT within 30 days was not associated with clinical outcomes or hemodynamic performance during long-term follow-up.

  • Imaging findings of thyroid diseases in children.

    Tsujioka Y, Yamada Y, Hasegawa T, Hashimoto M, Jinzaki M

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology 34 ( 2 ) 89 - 104 2025.04

    ISSN  0918-5739

    　View Summary

    We review the imaging findings in pediatric thyroid diseases that necessitate prompt diagnosis and timely medical intervention. Congenital hypothyroidism particularly represents a critical pediatric emergency. Ultrasonography stands as the primary modality for accurately assessing thyroid morphology and identifying thyroid dysgenesis.<sup>123</sup>I-scintigraphy mirrors iodine metabolism and thyroid hormone synthesis, and the concurrent application of perchlorate (perchloride discharge test) elucidates the pathogenesis of thyroid dyshormonogenesis. Nonetheless, radioiodine scintigraphy has seen limited utilization due to the intricacies of pre-test preparation.<sup>99m</sup>Tc-pertechnetate scintigraphy demonstrates high sensitivity in delineating thyroid tissues with minimal radiation exposure, facilitating the diagnosis of thyroid dysgenesis. Additionally, we have included brief insights on the imaging characteristics of central hypothyroidism, thyroiditis, and thyroid masses.

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 【胸部の最新画像情報2020】肺野の画像所見が診断の契機となったEhlers-Danlos症候群の1例

    松本 晋作, 杉浦 弘明, 南 康大, 山田 祥岳, 渡辺 理沙, 福永 興壱, 陣崎 雅弘

    臨床放射線 (金原出版(株))  65 ( 1 ) 67 - 70 2020.01

    Other, Joint Work,  ISSN  0009-9252

    　View Summary

    症例は40歳代女性で、胸痛を主訴に近医を受診し、胸部単純X線で左気胸を指摘され当院へ紹介入院となった。胸部単純CTにて左気胸を認めた。両肺底部に複数の不整な嚢胞、両下葉に浸潤影、小葉中心性陰影および気管支拡張を認めた。なお、約1年前の肺炎時のCTでは嚢胞は認められなかった。胸腔ドレーンを留置するも気胸およびリークの改善を認めなかったため、胸腔鏡下左肺下葉嚢胞切除術を施行した。術後経過は良好で、術後約1週間で退院した。比較的若年者に繰り返す肺炎後に不整な嚢胞が散見され、難治性の気胸を発症したことから肺組織の脆弱性が示唆され、基礎疾患としてEhlers-Danlos症候群の可能性が疑われた。遺伝子検査ではCOL5A2遺伝子変異が陽性(ミスセンス変異)であり、古典型Ehlers-Danlos症候群と診断された。また、COL3A1遺伝子変異は陰性であったことから、血管型Ehlers-Danlos症候群は否定された。

  • A case of Ehlers-Danlos syndrome in which lung CT findings contributed to the diagnosis

    松本 晋作, 杉浦 弘明, 南 康大, 山田 祥岳, 渡辺 理沙, 福永 興壱, 陣崎 雅弘

    臨床放射線 (金原出版(株))  65 ( 1 ) 67 - 70 2020.01

    Other, Joint Work,  ISSN  0009-9252

  • DAT SPECTにおけるCSFマスク補正のSBR値の診断能への影響

    岩渕 雄, 中原 理紀, 亀山 征史, 松坂 陽至, 南 康大, 伊東 大介, 田渕 肇, 山田 祥岳, 陣崎 雅弘

    核医学 ((一社)日本核医学会)  56 ( Suppl. ) S175 - S175 2019.10

    Other, Joint Work,  ISSN  0022-7854

  • 肺野異常陰影 3 肺間質影の鑑別

    杉浦弘明, 南康大, 山田祥岳, 陣崎雅弘

    画像診断 39 ( 11 ) A210‐215 2019.09

    Other, Joint Work,  ISSN  0285-0524

  • 肺野異常陰影 2 肺野空洞性病変の鑑別

    南康大, 山田祥岳, 杉浦弘明, 陣崎雅弘

    画像診断 39 ( 11 ) A204‐A209 2019.09

    Other, Joint Work,  ISSN  0285-0524

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Presentations 【 Display / hide 】

  • 体位が外頸静脈・板間静脈に与える影響　座位CTを用いた解析

    水谷 克洋, 宮内 翼, 山田 祥岳, 山田 稔, 横山 陽一, 小杉 健三, 吉田 啓佑, 秋山 武紀, 戸田 正博, 陣崎 雅弘

    日本脳神経血管内治療学会学術集会抄録集, 

    2024.11
    , 

    (一社)日本脳神経血管内治療学会

  • 原発性アルドステロン症における腎周囲脂肪蓄積の臨床的意義

    満野 竜ノ介, 中村 俊文, 金子 賢司, 児島 大輝, 中村 健吾, 水谷 洋佑, 山田 祥岳, 畔上 達彦, 神田 武志, 木内 謙一郎, 吉野 純, 林 香

    日本内分泌学会雑誌, 

    2024.10
    , 

    (一社)日本内分泌学会

  • 立位CT・床反力計同時計測による下肢荷重線の検討　内外側Wedgeの影響

    関 広幸, 荻原 直道, 伊藤 滉真, 筋野 朝陽, 山田 祥岳, 横山 陽一, 中村 雅也, 陣崎 雅弘, 名倉 武雄

    日本足の外科学会雑誌, 

    2024.10
    , 

    (一社)日本足の外科学会

  • 姿勢変化における脊柱可動域の性差　立位CTを用いた分析

    水越 諒, 八木 満, 山田 祥岳, 渡辺 航太, 名倉 武雄, 中村 雅也, 陣崎 雅弘

    日本整形外科学会雑誌, 

    2024.09
    , 

    (公社)日本整形外科学会

  • 原発性アルドステロン症における腎洞脂肪蓄積の臨床的意義の検証

    満野 竜ノ介, 金子 賢司, 中村 俊文, 児島 大輝, 水谷 洋佑, 畔上 達彦, 山口 慎太郎, 山田 祥岳, 陣崎 雅弘, 木内 謙一郎, 吉野 純, 林 香

    日本腎臓学会誌, 

    2024.06
    , 

    (一社)日本腎臓学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Elucidation of age-related changes and pathology and establishment of a method for early detection of diseases using upright CT: Aiming at extending healthy life expectancy

    2023.04
    -
    2026.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    現在の通常のCTは臥位で撮影するため、ヒトの日常生活の状態(立位/座位) を反映しておらず、立位/座位での様々な病態を3次元的に画像化できていなかった。そこで我々は産学共同で320列立位CTを開発し、当施設に世界第１号機を導入した。これまでの初期検討により、立位と臥位で解剖学的構造や各種病態はかなり異なる事が分かった。この初期結果をふまえ、本研究では、新たな診断機器である立位CTを用いて、立位荷重下でより顕著となる加齢性変化や各種病態を画像的に解明しつつ、立位/座位での新たな疾患早期検出法の確立を目指す。そして立位CTによる早期診断により、超高齢社会における健康寿命の更なる延伸、生活の質の向上を目指す。

  • Construction of CT Diagnostics in the Near Future: Aiming at Extending Healthy Life Span in the Super-aging Society

    2022.09
    -
    Present

    Takeda Science Foundation, 医学系研究助成 臨床, Principal investigator

  • Elucidation of human body function using upright CT ~Looking at the era of healthy longevity~

    2021.04
    -
    2024.03

    Keio University, Grants-in-Aid for Scientific Research, Jinzaki Masahiro, Grant-in-Aid for Scientific Research (B), No Setting

    　View Summary

    In the era of health and longevity, we aimed to promote the early detection and elucidation of functional disorders. To achieve this, we conducted research on the mechanisms of three functions: swallowing, urination, and walking. For swallowing function, we had a specialized chair designed, and developed a protocol for scanning and established a method for this examination. For urination function, we established a scanning protocol, and clarified the mechanism of normal urination. Imaging of patient groups revealed three patterns of urination disorders (benign prostatic hyperplasia, bladder neck sclerosis, neurogenic bladder). Thus, evaluating urination function appears useful in devising treatment strategies. Concerning walking function, the relation with posture was deemed significant, and software for objectively evaluating posture was developed. Additionally, software capable of measuring muscle volume with a 5% margin of error was developed, deemed useful in predicting frailty.

  • Development of an individual human homologous model generation method for dynamics analysis

    2021.04
    -
    2024.03

    National Institute of Advanced Industrial Science and Technology, Grants-in-Aid for Scientific Research, Endo Yui, Grant-in-Aid for Scientific Research (B), No Setting

    　View Summary

    A study was conducted to develop a method for generating individual human body models that can withstand use in dynamics analysis of body motion. A method was developed to construct an individual human body volume model using a CT image template from an individual's human skin shape obtained from a body scanner. Based on the obtained human body volume model, we also developed a method to identify the human body dynamics properties of an individual using the measurement data of standard movements as input. Furthermore, a whole-body musculoskeletal model of the human body was integrated into the system to estimate the degree of muscle activation during movement.

  • Diagnosis and treatment of lymphatic diseases using MR lymphangiography, photoacoustic imaging, and upright CT

    2021.04
    -
    2024.03

    Keio University, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    リンパ疾患はリンパ浮腫だけでも世界に1.7億人の患者がおり、癌患者の増加、手術の高度化などを背景に増加している。しかしリンパ系は殆どの疾患で診断も治療も十分に確立されていない。この主な原因はリンパ管の簡便な画像診断がなく、現在でも可視化が容易ではない事にある。従って、画像診断の進歩によるリンパ管の可視化と動態の解明が、これらの診療と研究を導くキーである。本研究では、先進的MRイメージングと独自のマルチモダリティアプローチにより、リンパ系の新規画像診断法の確立を目指す。リンパ管画像診断のレベルを押し上げ、より低侵襲で精密な治療へ展開する事で、リンパ管疾患に苦しむ多くの患者に福音をもたらしたい。

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Intellectual Property Rights, etc. 【 Display / hide 】

  • X線コンピュータ断層撮影装置

    Date applied： 特願2021-183419  2021.11 

    Date announced： 特開2023-070936  2023.05 

    Patent, Joint

  • 被検体の透明化方法および透明化された被検体の製造方法

    Date applied： 特願2020-082566  2020.05 

    Date announced： 特開2021-177146  2021.11 

    Date issued： 特許第7411223号 

    Date registered： 2023.12

    Patent, Joint

  • 外反母趾の予防方法

    Date applied： 特願2019-091025  2019.05 

    Date announced： 特開2020-185121  2020.11 

    Patent

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Awards 【 Display / hide 】

  • Magna Cum Laude award at the 102nd Scientific Assembly and Annual Meeting of the Radiological Society of North America

    2016.11, Radiological Society of North America, Dynamic Chest Radiography Using Flat Panel Detector System: Technique and Applications

    Type of Award： Award from international society, conference, symposium, etc.,  Country： United States

  • Platinum Medal (the Best Presentation Award) at the 79rd Annual Meeting of the Japan Radiological Society

    Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Mitsuru Murata, Koichi Fukunaga, Shotaro Chubachi, Masahiro Jinzaki, 2020.06, Japan Radiological Society, Comparison of Inspiratory and Expiratory Lung/Lobe Volumes Among Supine, Standing and Sitting Positions scanned with Conventional and 320-Detector-Row Upright CT

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Certificate of Merit Award at the 103rd Scientific Assembly and Annual Meeting of the Radiological Society of North America

    2017.11, Radiological Society of North America, Four-dimensional (4D) Computed Tomography (CT) with Non-rigid Registration Between Adjacent Phases Before and After Transcatheter Aortic Valve Implantation (TAVI): One Step Forward Into the Future

    Type of Award： Award from international society, conference, symposium, etc.,  Country： United States

  • Achievement Award, Japanese Society of Medical Imaging Technology

    Masahiro Jinzaki, Yoshitake Yamada, Minoru Yamada, Yoichi Yokoyama, Takeo Nagura, Naomichi Ogihara, Yasutaka Shindo, Makoto Nakano, 2022.07, Japanese Society of Medical Imaging Technology, Development of Whole-Body Upright Computed Tomography

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Silver Medal, the 80th Annual Meeting of the Japan Radiological Society

    Yoshitake Yamada, Shotaro Chubachi, Minoru Yamada, Yoichi Yokoyama, Akiko Tanabe, Shiho Matsuoka, Yuki Niijima, Mitsuru Murata, Koichi Fukunaga, Masahiro Jinzaki, 2021.04, Japan Radiological Society, Correlation between lung volumes on upright CT and measurements on pulmonary function test in COPD patients: comparison with supine CT

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Other 【 Display / hide 】

  • JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases: Cooperator

    2019年03月

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    JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases: Cooperator

  • 2016年01月

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    The Uehara Memorial Foundation, Overseas research fellowships

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, RADIOLOGY

    2025

  • CLINICAL CLERKSHIP IN RADIOLOGY

    2025

  • LECTURE SERIES, RADIOLOGY

    2024

  • CLINICAL CLERKSHIP IN RADIOLOGY

    2024

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2023

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Courses Previously Taught 【 Display / hide 】

  • 肝・胆・膵の画像診断

    慶應義塾大学医学部

    2018.04
    -
    2019.03

  • 骨盤腔の画像診断

    慶應義塾大学医学部

    2018.04
    -
    2019.03

  • 肝・胆・膵の画像診断

    Keio University

    2017.04
    -
    2018.03
    , 

    Full academic year

  • 肝・胆・膵の画像診断

    Keio University

    2015.04
    -
    2016.03
    , 

    Full academic year, Laboratory work/practical work/exercise

  • 女性骨盤臓器の画像診断

    Keio University

    2015.04
    -
    2016.03
    , 

    Full academic year, Laboratory work/practical work/exercise

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Educational Activities and Special Notes 【 Display / hide 】

  • The person in charge of Objective Structured Clinical Examination

    2019.04
    -
    Present

    , Special Affairs

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Memberships in Academic Societies 【 Display / hide 】

  • Japan Radiological Society, 

    2006
    -
    Present

  • The Japan Society of Ultrasonics in Medicine, 

    2014
    -
    Present

  • The Japanese Society of Nuclear Medicine, 

    2013
    -
    Present

  • Radiological Society of North America, 

    2010
    -
    Present

  • The Japanese Circulation Society, 

    2014
    -
    Present

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